OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11564322	Our hypothesis is confirmed by the measurement of the cell number, which showed no significant changes in the proliferation of the studied cell lines after cell treatments with the tested peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11301095	This variation may correlate with the differing effects of the amoeba at various stages of infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "variation", "may", "correlate", "with", "the",...
PMC10522430	However, the optimal dose was found to be 200 µg/mL at 24 hours, as it led to 39.2% viable cells without inducing cell toxicity while still inducing apoptosis in 45.6% of HeLa cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11206502	The anti-tumor activity of HB in vitro has also been proven against mammary carcinoma (4T1), melanoma (B16F10), and squamous cell carcinoma (SCCVII) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "...
PMC11737091	The datasets GSE53757 and GSE36895 in the GEO database provided additional evidence of DBF4 overexpression in ccRCC tumor tissues (Fig. 1D, E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11696576	The low number of associations to known drug resistance mechanisms led us to take a second approach that did not use filtering based on prior knowledge.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Eleven patients suffered from septic shock (13%), with seven patients (8%) passing away.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eleven", "patients", "suffer...
PMC11795610	Filaggrin mRNA. (	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Filaggrin", "mRNA", ".", "(" ] } ]
PMC11411004	P < 0.0001 vs. DMSO, *P < 0.001 vs. DMSO, P < 0.01 vs. DMSO, and *P < 0.05 vs. DMSO CHO-ADM cells treated with DMSO (closed circle), 0.5 μM (closed square), 1 μM (rising triangle), 2 μM (falling triangle), and 4 μM (open diamond) I-4 on day 3 of culture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705067	Furthermore, we explored the effect of low or high FDX and DLAT expression on immune cell infiltration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "explored", "...
PMC3995603	These mediators lead to immediate phase reactions in the tissue, such as redness and itching, shortly after allergen-IgE binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "mediators", ...
PMC11420784	Data are presented as the mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", "SD", "." ] } ]
PMC11682525	Additionally, we examined the alterations in the expression of specific genes (HIF1α, BDNF, and VEGF) following hypoxic conditioning.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additio...
PMC9429973	Methods: The activity of inhibitors of signaling pathways affecting OPN expression was evaluated in vitro in human primary monocytes, given their key role in OPN secretion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11322866	Scale bar: 2 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "2", "μm", "." ] } ]
PMC9429973	Aims: To determine the impact of hematologic disorders on 30-day mortality and other severe outcomes in patients with SARS-COV-2 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To",...
PMC9429973	For the Mel ≥ 3.28 mg/kg vs. Mel < 3.28 mg/kg groups, median OS was 57.5 months (95% CI: 39.5 – N.E) vs. 46.6 months (95% CI: 28.2 – 109.5, p=0.49) and median RFS was 51.4 months (95% CI: 30.7 – 70.4) vs. 29.7 months (95% CI: 18.1 – 98.0, p=0.36).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7685376	In addition, compared with paired adjacent tissues, the protein expression levels of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7 were also enhanced in HCC tissues (Figure 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	After removing as much subcutaneous fat issue as possible with scissors, the skin sample was divided into two halves.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "removing", "as", ...
PMC11295144	The cells plated on 13 mm coverslips coated with poly-L-lysine were briefly washed with PBS and fixed with 4% PFA/4% sucrose in PBS for 10 min at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10823017	The data represent N=3 independent experiments, mean ±SEM. (*	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "represent", "N=3", "independent", "experiments", ",", "mean", "±SEM", ...
PMC6337547	The antioxidant activities of rosmarinic acid and salvianolic acid B in plant extracts were determined using DPPH radical scavenging, superoxide radical quenching, a β-carotene-linoleic acid system, and reductive potential assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878278	On the other hand, our results in Figure 7 are interesting and provide strong evidence that BMP6 potentiates the production of IFNB1 transcripts and downstream response as seen by increased expression of MXA and IFIT1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The monosomy 7 clone regressed in 3 patients (P1-P3) and was no longer detectable at 3 months (P1) or 1 year (P2) from diagnosis (P3 was lost to follow-up at 12 months).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5600151	This PEG chain modification improved the stability and intracellular bioavailability in plasma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "PEG", "chain", "modification", "improved", "the", "stability", "and", "i...
PMC11345828	After arrival of the local animal facility at Boehringer Ingelheim RCV GmbH & Co KG mice were allowed to adjust to housing conditions at least for 5 days before the start of the experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9622879	Day-ahead GHI and outside temperature of day in Detroit city.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Day-ahead", "GHI", "and", "outside", "temperature", "of", "day", "in", "Detroit", "city", ...
PMC11604015	The efficacy of CAR-T cells is evaluated by CR rate within 1 monthCAR: chimeric antigen receptor; CR: complete response; CRS: cytokine response syndrome; TRBC: T cell receptor beta constant; ICANS: immune effector cell-associated neurotoxicity syndrome; CMV: cytomegalovirus; TKIs: tyrosine kinase inhibitors; EBV: Epstein-Barr virus; ER: endoplasmic reticulum; HSCT: hematopoietic stem cell transplantation; HLA: human leukocyte antigen; GvHD: graft versus host disease; CPISPR: clustered regularly interspaced short palindromic repeats; Cas9: CRISPR-associated protein 9; KO: knockout; TCR: T cell receptor Different target antigens of T cell-derived malignancies for CAR-T cell therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727062	Studies have demonstrated its efficacy in inhibiting the proliferation of melanoma cells in xenograft mouse models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "have", "demonstrated", "its", "efficacy", "...
PMC10142392	Linear diblock copolymers, PEG2000-PCL5800 and (PEG775)2-PCL5800, were also created, and it was discovered that the multi-arm structures resulted in smaller-sized micelles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11269933	Further validation of upstream kinases and regulatory pathways revealed that the PK Ser11 site was phosphorylated by ERK1/2 kinase and regulated by the classical MAPK pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Several antiviral agents, such as molnupiravir and remdesivir, and some monoclonal antibodies have been also used for the management of COVID-19 in order to reduce the risk of progression to severe disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743316	Consequently, the proliferation of cancer cells is greatly inhibited by blocking the ETC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "the", "proliferation", "of", "cancer", "cells", ...
PMC11792090	Furthermore, we demonstrated the process stability of SAP UCAR-T cell production and proved their scalability and clinical applicability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "demonst...
PMC11687167	The ORION series of trials investigated the effects of Inclisiran on lowering LDL-C levels and cardiovascular outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ORION", "series", "of", "trials", "i...
PMC10698968	3MF-R 3 cell line shows an aggressive phenotype in vitro.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3MF-R", "3", "cell", "line", "shows", "an", "aggressive", "phenotype", "in", "...
PMC11627398	Next, functional analysis and immune cells infiltration were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "functional", "analysis", "and", "immune", "cells", "infiltration", "were", "perform...
PMC11604768	Several TRE units were highly active in subsets of cell lines, suggesting certain transcription factors have cell-specific basal activities (Supplementary Fig. 8B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11746948	We subsequently verified the role of ZDHHC20 in regulating GPX4 palmitoylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "subsequently", "verified", "the", "role", "of", "ZDHHC20", "in", "regulating", ...
PMC9429973	Image: Summary/Conclusion: Based on ROARS data, which incorporated pts’ voices, there is a significant burden of SCD among pts in KSA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11407042	Statistical analysis was performed using one-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "performed", "using", "one-way", "ANOVA", "." ] } ]
PMC10728535	Moreover, SNCA (α‐Synuclein) is involved the development of various tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "SNCA", "(", "α‐Synuclein", ")", "is", "involved", "t...
PMC11306331	Optogenetic activation of cells expressing high levels of MBP-SspB-iRFP produced rapid dissolution of 3xFUS condensates in nearly all cells (Fig. 3B, high [MBP]), whereas cells harboring medium or low MBP expression dissolved condensates in progressively fewer cells (Fig. 3B, med [MBP], low [MBP]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	They carry a positive-sense RNA as genetic material and are commonly found in birds and other animals .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "carry", "a", "positive-sense", "RNA", ...
PMC4355729	After antigen retrieval, these sections were treated with 3% H2O2 solution, incubated with 8% bovine serum albumin for 30 min and primary antibody at 4°C overnight, then incubated with corresponding secondary antibody, and subsequently stained with DAB kit (ZSGB Bio).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473843	Notably, STAT3 activation has been linked to EMT and therapy resistance (Lee et al, 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "STAT3", "activati...
PMC10745221	Incubation temperature was 37°C for PRMT1, PRMT5, and controls, and 20°C for PRMT7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Incubation", "temperature", ...
PMC11746948	once every two days) for two weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "once", "every", "two", "days", ")", "for", "two", "weeks", "." ] } ]
PMC5173112	The cell lysate with SDS sample buffer was separated by denaturing SDS-PAGE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "lysate", "with", "SDS", "sample", "buffer", "was", "separated", ...
PMC9429973	Bone density scan and markers are in process to ascertain the impact of this treatment on bone density, although this may take longer to show beneficial effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	Genotypes were identified by PCR amplification on genomic DNA extracted from mousetails, four homozygous mice were obtained (B1, B3, B6, and B7 in Figure S1A; two female mouse and two male mouse).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Safety and efficacy outcomes were also evaluated during recurrences (recurrence population, n=19), including patients treated at least twice with CPLZ (received CPLZ in HERCULES or twice in post-HERCULES; repeat-use population, n=9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756907	Each experiment was repeated 3 times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "was", "repeated", "3", "times", "." ] } ]
PMC11082662	The protein concentration was detected with bicinchoninic acid (BCA) kit, after which the protein samples were uniformly diluted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", ...
PMC11295144	Data from N = 3 independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "from", "N", "=", "3", "independent", "experiments", "." ] } ]
PMC11489275	The mortality risk within 1 month was estimated based on different lymphocyte grouping methods, the lowest lymphocyte group had a higher mortality risk within 1 month compared with the highest group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	Cl8 cells were transfected using CellFectin II Reagent (Thermo Fisher Scientific).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cl8", "cells", "were", "transfected", "using", "CellFectin", "II", ...
PMC11742431	Tumor blocks were removed and photographed, and it was found that both the KVN‐treated group and the K14N‐treated group were able to significantly inhibit the growth of the tumor blocks, compared to the control group (Figure 7D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	HepG2 cells (ECACC No.85011430) were seeded as previously described .	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HepG2", "cells", "(", "ECACC", "No.85011430", ")", "were", "seeded", "as", "...
PMC11698348	Expression analysis has revealed that Elf5 expression was localised and elevated in stem/progenitor cell populations of both the epidermis (basal and suprabasal) and in HF bulge and hair germ stem cell (SCs) compartments during skin and hair development and cycling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	We observed minimal impact of hyperparameters on AUC, and therefore selected the least complex model (10 nodes in hidden layer, learning rate 0.0003, and batch size of 256).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Although the neuronal phenotype remains for several weeks, this condition is gradually reversed over time, with the cells regaining their epithelial morphology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11774112	RNA interference (RNAi)- and microRNA (miRNA)-based techniques represent powerful new strategies for cancer therapy.11,12 miRNAs are single-stranded RNAs approximately 18–24 nucleotides in sizes and are chosen from an RNA duplex with an asymmetrical configuration.13 An RNA-induced silencing complex can be formed when miRNAs cooperate with a member of the Argonaute family of proteins and other ancillary proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9027909	The cDNA synthesis specific for each miRNA was constructed using cDNA synthesis kit (YTA, Tehran, Iran) as explained previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC2118063	IRF8 was the gene that best distinguished the histologically defined CB subset of diffuse large B cell lymphomas (unpublished data).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IRF8", "was"...
PMC7185206	Cell survival was measured by trypan blue staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "survival", "was", "measured", "by", "trypan", "blue", "staining", "." ] } ]
PMC9429973	RBC transfusions remained reduced (82%; n=27 at last visit).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RBC", "transfusions", "remained", "reduced", "(", "82", "%", ";", "n=...
PMC2777936	Many of the changes in Wnt gene expression seen in induced differentiation of EC cells are also seen in induced differentiation of ES cells, highlighting the use of the EC system as a model for Wnt signalling in ES cell biology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485786	Scale bars: 200 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "200", "µm", "." ] } ]
PMC9429973	We defined collection efficiency, as the CD34+ cellularity obtained in relation to the expected (according to the processed volemia and the CD34+ pre-apheresis cells concentration in blood determined on a flow cytometer).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	On the other hand, depletion of BCAT1 leaves HR kinetics unmodified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "depletion", "of", "BCAT1", "leaves", "H...
PMC8839885	Interestingly, the activity of 2-hydroxyestradiol (2HE2), a prodrug of 2ME2, was much more potent than the activity of 2ME2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10965315	The individual data points and significant p‐values are shown in each column, and the data are represented as mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "indiv...
PMC9429973	Treatment discontinuation due to disease progression was 28% by INV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "discontinuation", "due", "to", "disease", "progression", "was", "28", "%", ...
PMC11746942	H&E staining revealed a reduction in epidermal thickness in KC-S1PR3-KD mice treated with IMQ, compared to that in control mice (Fig. 3F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11665584	Importantly, spatiotemporal regulation typically limits keratinocyte activation to only the cells migrating into or immediately adjacent to the wound bed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", ...
PMC11635087	A cover glass was then placed in the center of the dish and the dish was inverted and set on the stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "cover",...
PMC11247842	Due to the importance of mastitis for animal welfare, the knowledge obtained from this study will serve as a primary source for cattle mastitis research, cattle breeding, cattle management, and veterinary medicine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9532503	Modulating afucosylation in cell cultures is the cost effective and simple way to increase the ADCC activity and efficacy of the anti-CD20 monoclonal antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11085211	H NMR spectra were recorded at 25 °C on a Varian Inova instrument (equipped with a reverse triple resonance probe) operating at 600.13 MHz.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754436	Zou et al. revealed that deoxyhydroxyroasted saponin induced apoptosis in OS cells by activating the apoptosis-related proteins Bax and caspase 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zou", "et", "al."...
PMC11754784	As shown in Supplementary Fig. 15, when a molecule is near the boundary, its diffusion trajectory will expand laterally along the boundary accompanied by a large number of collisions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11298021	Rapamycin was applied to regulate the expression levels of the mTOR gene and its downstream signaling pathway in Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Rapamycin", "was", ...
PMC10654497	SFRGs, SLC family-related genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "SFRGs", ",", "SLC", "family-related", "genes", "." ] } ]
PMC11486946	Single-molecule imaging analysis has been used to visualize and measure the location and brightness of individual membrane receptor molecules in cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-molecule", "imag...
PMC9065483	In a study by Wang et al., tyrosine phosphorylation of the key IFN effector STING (STimulator of INterferon Genes) by EGFR was required for its proper cellular trafficking and downstream signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11377827	USP52 has been implicated in HIF regulation, through its global effect on RNA stability, and we validated this finding (Fig. EV1A) (Bett et al, 2013; Wolf and Passmore, 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	Of these seven SNPs, the lead SNP and one other fall into regions with chromatin marks consistent with enhancer activity in epithelial cells (HIOEC and NHEK) (Fig. 4a and Supplementary Fig. 4c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	Harvest cell lysates as noted in Step 5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Harvest", "cell", "lysates", "as", "noted", "in", "Step", "5", "." ] } ]
PMC11391695	Following that, the cells were fixed using a formaldehyde solution containing 4% and subsequently stained using a crystal violet solution containing 0.1%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8973725	EMT is triggered by many signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EMT", "is", "triggered", "by", "many", "signaling", "pathways", "." ] } ]
PMC11064533	This is in accordance with other studies where functional flagella were found as the basis for adhesion to host cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "in", "ac...
PMC11562028	The above results showed that the Re-CDs had low biotoxic side effects and good biosafety.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "above", "results", "showed", "that", "the", "Re-CDs"...
PMC9220170	In addition, it is known that there are Derlins (Derlins 1–3), the main function of which perform a similar function and are involved in the regulation of ER stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742670	SMILE representation.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "SMILE", "representation", "." ] } ]
PMC10813895	This efficacy is further diminished in women with dense breast tissue .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "efficacy", "is", "further", "diminished", "in", "women", "with", "dense", "br...
PMC4695073	C. Kaplan-Meier progression-free survival curves in the classified patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "Kaplan-Meier", "progression-free", "survival", "curves", "in", "the", "classified", "patients", "." ...
PMC11648299	Hazard Ratios (HRs) were calculated using Cox’s proportional-hazards regression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hazard", "Ratios", "(", "HRs", ")", "were", "calculated", "using", "Cox", ...
PMC11536589	The expression of MGST1 in AsPC1-MR cells was suppressed using two RNA interference molecules, siRNA1 and siRNA2 (Fig. 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11507371	Thus, developing innovative and targeted treatment options is crucial .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "developing", "innovative", "and", "targeted", "treatment", "options", "is", "crucia...

PMC11564322

Our hypothesis is confirmed by the measurement of the cell number, which showed no significant changes in the proliferation of the studied cell lines after cell treatments with the tested peptides.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11301095

This variation may correlate with the differing effects of the amoeba at various stages of infection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "variation", "may", "correlate", "with", "the",...

PMC10522430

However, the optimal dose was found to be 200 µg/mL at 24 hours, as it led to 39.2% viable cells without inducing cell toxicity while still inducing apoptosis in 45.6% of HeLa cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11206502

The anti-tumor activity of HB in vitro has also been proven against mammary carcinoma (4T1), melanoma (B16F10), and squamous cell carcinoma (SCCVII) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "...

PMC11737091

The datasets GSE53757 and GSE36895 in the GEO database provided additional evidence of DBF4 overexpression in ccRCC tumor tissues (Fig. 1D, E).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11696576

The low number of associations to known drug resistance mechanisms led us to take a second approach that did not use filtering based on prior knowledge.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

Eleven patients suffered from septic shock (13%), with seven patients (8%) passing away.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eleven", "patients", "suffer...

PMC11795610

Filaggrin mRNA. (

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Filaggrin", "mRNA", ".", "(" ] } ]

PMC11411004

P < 0.0001 vs. DMSO, ***P < 0.001 vs. DMSO, **P < 0.01 vs. DMSO, and *P < 0.05 vs. DMSO CHO-ADM cells treated with DMSO (closed circle), 0.5 μM (closed square), 1 μM (rising triangle), 2 μM (falling triangle), and 4 μM (open diamond) I-4 on day 3 of culture.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11705067

Furthermore, we explored the effect of low or high FDX and DLAT expression on immune cell infiltration.

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PMC3995603

These mediators lead to immediate phase reactions in the tissue, such as redness and itching, shortly after allergen-IgE binding.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "mediators", ...

PMC11420784

Data are presented as the mean ± SD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "the", "mean", "±", "SD", "." ] } ]

PMC11682525

Additionally, we examined the alterations in the expression of specific genes (HIF1α, BDNF, and VEGF) following hypoxic conditioning.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additio...

PMC9429973

Methods: The activity of inhibitors of signaling pathways affecting OPN expression was evaluated in vitro in human primary monocytes, given their key role in OPN secretion.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11322866

Scale bar: 2 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "2", "μm", "." ] } ]

PMC9429973

Aims: To determine the impact of hematologic disorders on 30-day mortality and other severe outcomes in patients with SARS-COV-2 infection.

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PMC9429973

For the Mel ≥ 3.28 mg/kg vs. Mel < 3.28 mg/kg groups, median OS was 57.5 months (95% CI: 39.5 – N.E) vs. 46.6 months (95% CI: 28.2 – 109.5, p=0.49) and median RFS was 51.4 months (95% CI: 30.7 – 70.4) vs. 29.7 months (95% CI: 18.1 – 98.0, p=0.36).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7685376

In addition, compared with paired adjacent tissues, the protein expression levels of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7 were also enhanced in HCC tissues (Figure 3D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11762280

After removing as much subcutaneous fat issue as possible with scissors, the skin sample was divided into two halves.

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PMC11295144

The cells plated on 13 mm coverslips coated with poly-L-lysine were briefly washed with PBS and fixed with 4% PFA/4% sucrose in PBS for 10 min at room temperature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10823017

The data represent N=3 independent experiments, mean ±SEM. (*

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "represent", "N=3", "independent", "experiments", ",", "mean", "±SEM", ...

PMC6337547

The antioxidant activities of rosmarinic acid and salvianolic acid B in plant extracts were determined using DPPH radical scavenging, superoxide radical quenching, a β-carotene-linoleic acid system, and reductive potential assays.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9878278

On the other hand, our results in Figure 7 are interesting and provide strong evidence that BMP6 potentiates the production of IFNB1 transcripts and downstream response as seen by increased expression of MXA and IFIT1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The monosomy 7 clone regressed in 3 patients (P1-P3) and was no longer detectable at 3 months (P1) or 1 year (P2) from diagnosis (P3 was lost to follow-up at 12 months).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5600151

This PEG chain modification improved the stability and intracellular bioavailability in plasma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "PEG", "chain", "modification", "improved", "the", "stability", "and", "i...

PMC11345828

After arrival of the local animal facility at Boehringer Ingelheim RCV GmbH & Co KG mice were allowed to adjust to housing conditions at least for 5 days before the start of the experiment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9622879

Day-ahead GHI and outside temperature of day in Detroit city.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Day-ahead", "GHI", "and", "outside", "temperature", "of", "day", "in", "Detroit", "city", ...

PMC11604015

The efficacy of CAR-T cells is evaluated by CR rate within 1 monthCAR: chimeric antigen receptor; CR: complete response; CRS: cytokine response syndrome; TRBC: T cell receptor beta constant; ICANS: immune effector cell-associated neurotoxicity syndrome; CMV: cytomegalovirus; TKIs: tyrosine kinase inhibitors; EBV: Epstein-Barr virus; ER: endoplasmic reticulum; HSCT: hematopoietic stem cell transplantation; HLA: human leukocyte antigen; GvHD: graft versus host disease; CPISPR: clustered regularly interspaced short palindromic repeats; Cas9: CRISPR-associated protein 9; KO: knockout; TCR: T cell receptor Different target antigens of T cell-derived malignancies for CAR-T cell therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11727062

Studies have demonstrated its efficacy in inhibiting the proliferation of melanoma cells in xenograft mouse models.

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PMC10142392

Linear diblock copolymers, PEG2000-PCL5800 and (PEG775)2-PCL5800, were also created, and it was discovered that the multi-arm structures resulted in smaller-sized micelles.

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PMC11269933

Further validation of upstream kinases and regulatory pathways revealed that the PK Ser11 site was phosphorylated by ERK1/2 kinase and regulated by the classical MAPK pathway.

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PMC9429973

Several antiviral agents, such as molnupiravir and remdesivir, and some monoclonal antibodies have been also used for the management of COVID-19 in order to reduce the risk of progression to severe disease.

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PMC11743316

Consequently, the proliferation of cancer cells is greatly inhibited by blocking the ETC.

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PMC11792090

Furthermore, we demonstrated the process stability of SAP UCAR-T cell production and proved their scalability and clinical applicability.

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PMC11687167

The ORION series of trials investigated the effects of Inclisiran on lowering LDL-C levels and cardiovascular outcomes.

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PMC10698968

3MF-R 3 cell line shows an aggressive phenotype in vitro.

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PMC11627398

Next, functional analysis and immune cells infiltration were performed.

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PMC11604768

Several TRE units were highly active in subsets of cell lines, suggesting certain transcription factors have cell-specific basal activities (Supplementary Fig. 8B).

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PMC11746948

We subsequently verified the role of ZDHHC20 in regulating GPX4 palmitoylation.

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PMC9429973

Image: Summary/Conclusion: Based on ROARS data, which incorporated pts’ voices, there is a significant burden of SCD among pts in KSA.

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PMC11407042

Statistical analysis was performed using one-way ANOVA.

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PMC10728535

Moreover, SNCA (α‐Synuclein) is involved the development of various tumors.

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PMC11306331

Optogenetic activation of cells expressing high levels of MBP-SspB-iRFP produced rapid dissolution of 3xFUS condensates in nearly all cells (Fig. 3B, high [MBP]), whereas cells harboring medium or low MBP expression dissolved condensates in progressively fewer cells (Fig. 3B, med [MBP], low [MBP]).

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PMC9812014

They carry a positive-sense RNA as genetic material and are commonly found in birds and other animals .

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PMC4355729

After antigen retrieval, these sections were treated with 3% H2O2 solution, incubated with 8% bovine serum albumin for 30 min and primary antibody at 4°C overnight, then incubated with corresponding secondary antibody, and subsequently stained with DAB kit (ZSGB Bio).

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PMC11473843

Notably, STAT3 activation has been linked to EMT and therapy resistance (Lee et al, 2014).

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PMC10745221

Incubation temperature was 37°C for PRMT1, PRMT5, and controls, and 20°C for PRMT7.

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PMC11746948

once every two days) for two weeks.

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PMC5173112

The cell lysate with SDS sample buffer was separated by denaturing SDS-PAGE.

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PMC9429973

Bone density scan and markers are in process to ascertain the impact of this treatment on bone density, although this may take longer to show beneficial effects.

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PMC11794847

Genotypes were identified by PCR amplification on genomic DNA extracted from mousetails, four homozygous mice were obtained (B1, B3, B6, and B7 in Figure S1A; two female mouse and two male mouse).

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PMC9429973

Safety and efficacy outcomes were also evaluated during recurrences (recurrence population, n=19), including patients treated at least twice with CPLZ (received CPLZ in HERCULES or twice in post-HERCULES; repeat-use population, n=9).

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PMC11756907

Each experiment was repeated 3 times.

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PMC11082662

The protein concentration was detected with bicinchoninic acid (BCA) kit, after which the protein samples were uniformly diluted.

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PMC11295144

Data from N = 3 independent experiments.

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PMC11489275

The mortality risk within 1 month was estimated based on different lymphocyte grouping methods, the lowest lymphocyte group had a higher mortality risk within 1 month compared with the highest group.

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PMC11721587

Cl8 cells were transfected using CellFectin II Reagent (Thermo Fisher Scientific).

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PMC11742431

Tumor blocks were removed and photographed, and it was found that both the KVN‐treated group and the K14N‐treated group were able to significantly inhibit the growth of the tumor blocks, compared to the control group (Figure 7D).

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PMC10114490

HepG2 cells (ECACC No.85011430) were seeded as previously described .

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PMC11698348

Expression analysis has revealed that Elf5 expression was localised and elevated in stem/progenitor cell populations of both the epidermis (basal and suprabasal) and in HF bulge and hair germ stem cell (SCs) compartments during skin and hair development and cycling.

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PMC11785489

We observed minimal impact of hyperparameters on AUC, and therefore selected the least complex model (10 nodes in hidden layer, learning rate 0.0003, and batch size of 256).

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PMC11599565

Although the neuronal phenotype remains for several weeks, this condition is gradually reversed over time, with the cells regaining their epithelial morphology.

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PMC11774112

RNA interference (RNAi)- and microRNA (miRNA)-based techniques represent powerful new strategies for cancer therapy.11,12 miRNAs are single-stranded RNAs approximately 18–24 nucleotides in sizes and are chosen from an RNA duplex with an asymmetrical configuration.13 An RNA-induced silencing complex can be formed when miRNAs cooperate with a member of the Argonaute family of proteins and other ancillary proteins.

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PMC9027909

The cDNA synthesis specific for each miRNA was constructed using cDNA synthesis kit (YTA, Tehran, Iran) as explained previously .

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PMC2118063

IRF8 was the gene that best distinguished the histologically defined CB subset of diffuse large B cell lymphomas (unpublished data).

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PMC7185206

Cell survival was measured by trypan blue staining.

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PMC9429973

RBC transfusions remained reduced (82%; n=27 at last visit).

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PMC2777936

Many of the changes in Wnt gene expression seen in induced differentiation of EC cells are also seen in induced differentiation of ES cells, highlighting the use of the EC system as a model for Wnt signalling in ES cell biology.

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PMC4485786

Scale bars: 200 µm.

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PMC9429973

We defined collection efficiency, as the CD34+ cellularity obtained in relation to the expected (according to the processed volemia and the CD34+ pre-apheresis cells concentration in blood determined on a flow cytometer).

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PMC11676169

On the other hand, depletion of BCAT1 leaves HR kinetics unmodified.

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PMC8839885

Interestingly, the activity of 2-hydroxyestradiol (2HE2), a prodrug of 2ME2, was much more potent than the activity of 2ME2.

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PMC10965315

The individual data points and significant p‐values are shown in each column, and the data are represented as mean ± SD.

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PMC9429973

Treatment discontinuation due to disease progression was 28% by INV.

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PMC11746942

H&E staining revealed a reduction in epidermal thickness in KC-S1PR3-KD mice treated with IMQ, compared to that in control mice (Fig. 3F).

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PMC11665584

Importantly, spatiotemporal regulation typically limits keratinocyte activation to only the cells migrating into or immediately adjacent to the wound bed.

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PMC11635087

A cover glass was then placed in the center of the dish and the dish was inverted and set on the stage.

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PMC11247842

Due to the importance of mastitis for animal welfare, the knowledge obtained from this study will serve as a primary source for cattle mastitis research, cattle breeding, cattle management, and veterinary medicine.

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PMC9532503

Modulating afucosylation in cell cultures is the cost effective and simple way to increase the ADCC activity and efficacy of the anti-CD20 monoclonal antibody.

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PMC11085211

H NMR spectra were recorded at 25 °C on a Varian Inova instrument (equipped with a reverse triple resonance probe) operating at 600.13 MHz.

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PMC11754436

Zou et al. revealed that deoxyhydroxyroasted saponin induced apoptosis in OS cells by activating the apoptosis-related proteins Bax and caspase 3.

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PMC11754784

As shown in Supplementary Fig. 15, when a molecule is near the boundary, its diffusion trajectory will expand laterally along the boundary accompanied by a large number of collisions.

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PMC11298021

Rapamycin was applied to regulate the expression levels of the mTOR gene and its downstream signaling pathway in Jurkat cells.

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PMC10654497

SFRGs, SLC family-related genes.

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PMC11486946

Single-molecule imaging analysis has been used to visualize and measure the location and brightness of individual membrane receptor molecules in cells.

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PMC9065483

In a study by Wang et al., tyrosine phosphorylation of the key IFN effector STING (STimulator of INterferon Genes) by EGFR was required for its proper cellular trafficking and downstream signaling.

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PMC11377827

USP52 has been implicated in HIF regulation, through its global effect on RNA stability, and we validated this finding (Fig. EV1A) (Bett et al, 2013; Wolf and Passmore, 2014).

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PMC11538390

Of these seven SNPs, the lead SNP and one other fall into regions with chromatin marks consistent with enhancer activity in epithelial cells (HIOEC and NHEK) (Fig. 4a and Supplementary Fig. 4c).

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PMC4270159

Harvest cell lysates as noted in Step 5.

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PMC11391695

Following that, the cells were fixed using a formaldehyde solution containing 4% and subsequently stained using a crystal violet solution containing 0.1%.

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PMC8973725

EMT is triggered by many signaling pathways.

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PMC11064533

This is in accordance with other studies where functional flagella were found as the basis for adhesion to host cells.

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PMC11562028

The above results showed that the Re-CDs had low biotoxic side effects and good biosafety.

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PMC9220170

In addition, it is known that there are Derlins (Derlins 1–3), the main function of which perform a similar function and are involved in the regulation of ER stress.

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PMC11742670

SMILE representation.

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PMC10813895

This efficacy is further diminished in women with dense breast tissue .

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PMC4695073

C. Kaplan-Meier progression-free survival curves in the classified patients.

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PMC11648299

Hazard Ratios (HRs) were calculated using Cox’s proportional-hazards regression.

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PMC11536589

The expression of MGST1 in AsPC1-MR cells was suppressed using two RNA interference molecules, siRNA1 and siRNA2 (Fig. 4A).

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PMC11507371

Thus, developing innovative and targeted treatment options is crucial .

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