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PMC11549062
However, since some experiments are more difficult to perform with human carotid artery smooth muscle cells and COS7 cells are easier to handle and commonly used in experimental research, we chose the COS7 cell line for certain experiments in this study.
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PMC11726848
Also, we registered a more pronounced decrease in cell growth rate after HDR irradiation compared to LDR irradiation at similar doses (Figure 3).
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PMC8996378
The cytotoxicity of compounds 44–48 was evaluated against A549, MDA-MB-231, KB, and MCF-7 cancer cell lines and the KB-VIN MDR cancer cell line.
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PMC11240448
A connection from one network module (j) to another (k) is quantified as the fractional change in the output of the affected module k brought about by a 1% change in the output of the effector module j when both these modules are considered in isolation from the network.
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PMC11400680
The prompt encoder is a unique feature of SAM that cannot be found in other segmentation models.
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PMC11604768
MPRAnalyze utilizes raw NGS read data of individual barcodes to perform comparisons of individual promoters between treatment groups.
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PMC11555465
The suspension of T. gondii was quickly passed through the column and the filtrate was collected and centrifuged at 3,000 × g for 8 min on 37°C to remove the supernatant and the precipitate was the T. gondii.
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PMC11643361
Complex 69 exhibited the highest activity among all tested compounds, with IC50 values as low as 1.4 μM for A2780, and significantly lower than cisplatin for A2780R and HOS, at 8.3 μM and 4.7 μM, respectively.
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PMC6268318
Toxicity studies have reported the activity of an ethanolic extract in the brine shrimp lethality test .
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PMC8998437
We previously reported that CCR1 and CCR2B are induced upon Epstein-Barr virus (EBV) infection of B cells in vitro.
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PMC11472639
Thus, in vivo, it might be the case that exercise during daratumumab infusions may exacerbate the reduction in absolute NK-cell frequency (via daratumumab mediated NK-cell fratricide) and may outweigh the benefits arising from any modest clonal plasma cell mobilisation, highlighting the importance of exercise timing during therapy, as described recently (Collier-Bain et al., 2023).
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PMC11679892
Among childhood cancers, neuroblastoma holds a particularly critical position.
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PMC11756514
Moreover, the addition of EDTA completely abolished langerin ECD binding ( Figure 3C ).
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PMC11476106
In this study, we successfully cultivated two ES cell lines in simple, economical and quick-to-manufacture 3D models.
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PMC9429973
Aims: We aimed to investigate the epidemiology, clinical features and prognosis of PG-TCL.
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PMC11680049
When comparing the obtained results with the cytotoxicity of the drug Taxol (Paclitaxel), it should be noted that the drug also exhibits more toxic effects on the HeLa and A-172 cells while being less toxic to HepG2 cells.
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PMC3888431
The automatic annotation pipeline Metanor-Euk was applied on both data sets with different BLAST searches against various databases, including SwissProt , KEGG , KOG , and eggNOG , and HMM based tools such as Pfam , InterProScan , and Panther for functional prediction.
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PMC11089031
In addition, the expression of G3BP2 and TM9SF2 were lower in ccRCC compared with normal tissues.
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PMC9429973
Results: Flow cytometry analyses suggested that additional exposure to the parasite enhances erythropoiesis.
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PMC9429973
Results: In this study, 53 patients were randomized to PEG (n=35) or CTRL (n=18).
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PMC8623816
The role of the ‘interrupted’ poly-A tails of RsRV5 in viral replication deserves further exploration.
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PMC11621565
Recent studies showed an altered intracellular α-synuclein and an increase of the intracellular α-synuclein levels in a mouse enteroendocrine cell line after exposure to LPS, suggesting the possible role of LPS in initiating PD pathology in the gastrointestinal tract.
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PMC11473843
About 30% of NSCLCs are driven by an activating KRAS mutation, which renders them aggressive and treatment resistant.
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PMC11698348
At 70% confluence, 3T3 cells were treated with 8μg/ml mitomycin C (ThermoFisher, UK) for 2 hours.
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PMC8409415
Given that the effectiveness of CD70‐ADC therapy in patients with OvCA has been poorly studied, we examined the antitumor activity of CD70‐ADC in OvCA cases.
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PMC10411253
The three-dimensional molecular structure of AMH constructed by Swiss-PdbViewer.
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PMC11653168
Tumor sizes were measured using a digital caliper thrice weekly until the day of sacrifice and tumor volume was calculated using the following formula: Tumor volume=length × width.
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PMC11462673
A Schematic diagram of the vivo experimental design.
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PMC7642379
Low consensus scores, represented by a dark blue color, indicate more significant differences. (
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PMC9646302
Similar results regarding LAPTM5 overexpression were obtained in BALB/c nude mice.
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PMC11012313
Increased activity of mTOR is associated with increases in HIF-1α levels .
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PMC10968586
Further experiments on MCF-7 cell line demonstrated a dose-dependent OLE-mediated antiproliferative effect on 17β-estradiol (E2)-induced cell growth when OLE concentration was used in the range of 10–75 μM. Instead, concentrations ≥ 100 μM were found to be toxic .
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PMC11012012
Compared to PEL cell lines, the expression of SLAMF7/CD319 was weaker in MM cell lines and normal B cells from a healthy donor, while Z138 mantle lymphoma cells were found to be SLAMF7/CD319-negative.
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PMC4360730
For example, the hepatic portal vein and the left lobe of a liver are both parts of a liver, but a list of controlled vocabularies does not capture this relationship.
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PMC6190245
Effect of synchronous radiotherapy and Ferula gummosa resin on Cell Proliferation The HeLa cells were treated with various concentrations of Ferula gummosa (0-250 µg/ml) for 24, 48 and 72 hr.
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PMC9429973
Mean blast concentration was 0.47ev/µL (range 0-25ev/µL) in all samples and 2 ev/µL (range 0.01-25ev/µL, median 0.53ev/µL) in FC+ samples.
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PMC10588957
Based on this experiment, the pro-apoptotic autophagy effect mediated by DATS on HepG2 cells may be related to the AMPK/SIRT1 signalling pathway.
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PMC11574029
Subsequently, total RNA was reverse transcribed into cDNA using the PrimeScript™ RT Reagent Kit (Perfect Real Time) (Takara, Japan).
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PMC9429973
Dual blockade of PD-1 and lymphocyte-activation gene 3 (LAG-3) has demonstrated antitumor activity in preclinical models.
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PMC11713609
To this end, we first examined whether PHLDA2 is directly involved in modulating p53-dependent ferroptotic response upon high levels of ROS.
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PMC9429973
At the time of COVID-19 diagnosis, IgG anti-spike antibodies were measured in 16 pts, 4 were no responders and the median level for those who did response was 176,6 AU/ml (IQR 86,6-879,8).
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PMC11670954
BA can be absorbed by colon epithelial cells, serving as the primary energy source for these cells.
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PMC9429973
A. Kattamis, J. Kwiatkowski, F. Tricta, E. Igboekwe, C. Fradette, A. Piga, S. Sheth National and Kapodistrian University of Athens, Athens, Greece; The Children’s Hospital of Philadelphia and Perelman School of Medicine of the University of Pennsylvania, Philadelphia, United States of America; Chiesi Canada Corporation, Toronto, Canada; Chiesi USA, Inc., Boston, United States of America; University of Turin, Turin, Italy; New York Presbyterian Hospital/Weill Cornell Medical College, New York, United States of America Background: Patients with thalassemia syndromes or sickle cell disease receiving regular blood transfusions may experience iron overload.
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PMC10170482
Mitochondria-specific reactive oxygen species were measured in Alexander and HepG2 cells cultivated for 7 days in either MC or CS conditions.
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PMC11617590
In a mutant Kirsten rat sarcoma viral oncogene homolog (KRAS)‐like‐dependent human cancer cell line such as in Mia PaCa‐2 cells, the inactivation of GSK3‐β induces apoptosis via the accumulation of β‐catenin .
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PMC9351137
Telophase synchronization was followed by subcellular fractionation assays to recover the cytoplasmic component (S2 fraction) and segregate away the chromatin-associated components (see “Methods”).
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PMC9429973
Included patients had a hemoglobin (Hb) level of ≤10 g/dL and were excluded if they received rituximab monotherapy <3 months, or combination therapy <6 months, prior to enrollment.
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PMC9429973
M. Santiago Balsera, A. Liquori, J. V. Gil, G. Avetisyan, Á. Díaz, L. Cordón, B. Martín, E. Mora, A. Villalba, B. Sánchez, I. Gómez, C. Moscardó, B. Ferrer, J. Serrano, E. González, M. Morote, C. Sargas, C. García, C. Martínez, B. Fernández, M. Guaita, A. San Juan, M. Ibáñez, E. Barragán, P. Montesinos, J. de la Rubia, Á. Zúñiga, G. Sanz, E. Such, J. Cervera Hematology; Genetics; Hematology Research Group; Molecular Biology, Hospital La Fe, Valencia; Hematology, Hospital Vinalopó, Elche; Hematology, Hospital General Albacete, Albacete; Hematology, Hospital General Alicante Dr Balmis, Alicante; Hematology, Hospital Clinico Universitario, Valencia; Hematology, Hospital Reina Sofia, Cordoba, Spain Background: Clinical heterogeneity, variable latency, and incomplete penetrance characteristic of inherited myeloid malignancies syndromes (HMMSs) suggest that the acquisition of additional alterations are potential drivers of clonality and are required for myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) onset.
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PMC11240052
After 4 h, DMEM-F12 containing 1 % penicillin-streptomycin and 10 % FBS was added to each well.
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PMC11754784
d Flow cytometry-based statistical analysis of phagocytosis of different cells by macrophages.
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PMC9031474
The effects are comparable to the chemotherapeutics paclitaxel and vinblastine.
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PMC11707577
Using an orthogonal approach (nanoarchitectonics), the surface of the capsid was chemically functionalized (Figure 1A).
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PMC11476004
Soukup et al. diagnosed papillary squamous cell carcinoma in large dogs over the age of five years.
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PMC9429973
A three-compartment model adequately fit the data, and a combination of time-dependent serum creatinine, baseline albumin, and allometrically scaled body weight best predicted methotrexate clearance.
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PMC10237474
As in (A), but with protein 2 with a C-terminal Fc tag. (
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PMC7433824
After the cells covered 70%‐80% of the plate surface, cells were harvested with trypsin‐EDTA and passaged.
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PMC9429973
Aims: We aimed to elucidate transcriptional programs that are maintained by aberrant EVI1 expression and to systematically identify vulnerabilities of EVI1-driven AML.
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PMC11545737
Pralnacasan (VX-740) and belnacasan (VX-765) inhibit caspase-1 activation.
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PMC11637276
RNA sequencing data from pancreatic ductal adenocarcinoma and normal pancreas was performed using TNMplot (tnmplot.com), which enables a direct comparison of tumour and normal samples and runs a Mann–Whitney U test .
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PMC11401358
The secondary structure changes of SF were further characterized by ATR-FTIR spectra.
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PMC8978939
The raw data supporting the conclusions of this article will be made available by the authors without undue reservation.
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PMC11741906
The miRNA targets were pooled together and linked to KEGG to identify the enrichment of these targets in various biological pathways.
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PMC11777207
Mouse PD-L1 and CD80 tail structures were predicted using Phyr2 Protein Fold Recognition.
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PMC10938377
To confirm compound binding to and reactivity with chromatin, many trials were conducted by incubating nucleosome core particle (NCP) crystals with each of the conjugates at different concentrations and for different durations, followed by analysis with X-ray crystallography (Fig. 2, S12–S14 and Tables S1–S3†).
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PMC10123657
Co-cultures of mouse and human cells have been used to study this effect , and the intercellular transfer of mitochondria, vesicles, and galectin-3 from MSC to leukemic cells, has been associated with this protection in experimental settings where transfer goes from human to human and from mouse to human cells .
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PMC9454178
The mouse experiments were approved by the Institutional Review Boards of Zhongshan Hospital.
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PMC6222635
Dendrobium officinale is a medicinal plant that has been widely used in China for thousands of years.
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PMC11413393
Conversely, for the 664 genes found to be significantly down regulated by day 3 of MS023 treatment (FDR ≤ 0.01, log2(FC) ≤ −1) a total of 20 GO biological process pathways filtered to the most specific subclass were detected with an overrepresentation of at least 2 fold and a FDR of ≤ 0.05 (Supplementary Fig. 5).
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PMC11665584
Neutrophils are recruited to the skin following injury to deposit proinflammatory, antimicrobial, and tissue-remolding granules.
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PMC11535726
Species exhibiting the sporidesmium-like features are K.acutispora, K.agumbensis, K.aquatica, K.bulbosapicalis, K.cangshanensis, K.crustacea, K.dujuanhuensis, K.dushanensis, K.extensum, K.fluminicola, K.guangdongensis, K.longirostrata, K.pini, K.puerensis, K.rostrata, K.sichuanensis, K.spatiosum, K.submersa, K.tectonae, K.thailandica and K.xishuangbannaensis (Su et al. 2016; Jayawardena et al. 2022; Xu et al. 2023; Yang et al. 2023; Jin et al. 2024; Sruthi et al. 2024; this study).
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PMC8345486
Compound 25 provided a clear example of the structure–activity relationship, showing the important role of sandwich-type closo-metalla bis(dicarbollide) ion versus free nido-7,8-dicarbaundecaborate ligand, which is almost nontoxic.
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PMC11655498
BBLF1 is a myristoylated and palmitoylated protein, whose myristoylation enhances its stability and facilitates its membrane anchoring in the trans-Golgi network (TGN).
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PMC11291490
The cells were separately incubated with the antibodies at 4 °C, 30 min.
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PMC11139449
Specifically, at 48 hours, the IC50 for CHO-K1 was measured as 7.28 mM; also, for CASP8AP2 gene knockout, it was increased to 14.25 mM. at 72 hours, the IC50 for CHO-K1 was measured as 5.56 mM, and for CHO-KO was increased to 7.80 mM. This finding was substantiated by statistically significant P-values at different time points, (P-value: 24 hours ≤ 0.0001, P-value: 48 hours ≤ 0.0001, P-value: 72 hours = 0.0007).
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PMC11391695
I The changes of telomere length in si-NC, si-TERT and si-ACYP2 + si-TERT treatment groups were observed by fluorescence in situ hybridization and qRT-PCR.
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PMC9688728
Spectra were collected from 35–700 m/z at 70 eV electron ionization energy.
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PMC8873393
E The average relative transcript levels within each cluster presented in Fig. 3D are shown, with the log2 expression values on the y axis and time on the x axis.
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PMC7136814
In RD the combination of Vincristine and TPA/GSK126 was therefore 1.5 times more effective than Vincristine alone and 4.8 times more effective than TPA/GSK126 alone.
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PMC9429973
Results: Fifty pts with WM (17 TN; 33 R/R), were enrolled from December 2019 to June 2021 across 10 academic and community medical centers in the US.
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PMC4839679
These genes code for glycolytic enzymes, solute carriers, and proteins involved in cholesterol homeostasis.
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PMC11705484
Co‐immunoprecipitation (Co‐IP) was performed with proteins from 5637 cells and TRMT61A or NF‐κB antibody or control IgG, followed by Western blot analysis with NF‐κB and TRMT61A antibodies. (
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PMC11116779
This is the basis for a deeper understanding of the health effects of a “new” and partly unknown toxicological agent.
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PMC11530949
The existence of improved dispersibility of Ag NPs in the nanorod-like morphology of CuO is confirmed by the Ag-doped CuO NPs cermet FESEM pictures.
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PMC11803210
Our data supplement existing work on the estrogenic effects of plant-derived compounds.
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PMC5415764
In this study, we observed iRGD ligands grafted on LPNs could remarkably enhance the cellular uptake in both A2780 and A2780/PTX cells, indicated that iRGD peptide could improve drugs internalization.
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PMC10898159
It located on chromosome 4q12 and contains 976 amino acids, which encodes a transmembrane protein belonging to the type III family of RTK (receptor tyrosine kinases) .
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PMC5415764
Hence, the encapsulation of multiple drug cargoes within a single nanocarrier could facilitate the simultaneous delivery of drugs at a precise combination ratio at the tumor site1617.
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PMC11471176
This has also been proposed by other research groups that have shown that carnosine may affect the expression and activity of mTOR, another signaling marker in this same pathway .
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PMC9429973
The 5-year and 10-year PFS were 42% and 21%, respectively.
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PMC11306331
n = 10,10 cells from conditions labeled left to right, pooled from three biological replicates.
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PMC9429973
Additional efficacy analyses will include progression-free survival and overall survival.
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PMC9429973
Most patients experienced negative (very or somewhat negative) impacts on emotional health (90%), physical health (87%), financial health (75%), social health (70%), and cognitive health (66%) since their diagnosis.
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PMC11543853
The observed membrane warping may be related to the previously characterized formation of membrane protrusions, which enable early and sorting endosomes to sort and recycle cargo, receptors, and membranes.
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PMC11706491
Septating time was measured as the time lapse between Sid2-GFP or GFP-CRIB fluorescence appeared at the septum and the 2 daughter cells were clearly separated.
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PMC10854447
In vitro investigations revealed that compounds 7j, 7k, and 7l were effective antiproliferative agents that could operate as dual EGFR/VEGFR-2 inhibitors.
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PMC11204465
This reviews the current research progress in the isolation of STCs and AFs, including the biosynthetic pathway, source of isolation, structure identification process, chemical synthesis, and biological activity.
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PMC11045125
LMP1 expression at high levels induces both total STAT3 and total Src expression, as well as the amount of phosphorylated STAT3, but does not alter the level of Myc expression.
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PMC2614415
Diagram represents an interaction network of the 8 genes and Aurora-A kinase. (
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PMC11461833
LaminA-pCAG-3HA was coimmunoprecipitated from HEK293T cells transfected with STXBP5-over-vector-FLAG or over-vector-FLAG, containing only the FLAG tag.
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PMC9221284
Indeed, BL60 exhibits an increased amount of c-Myc2 and fails to synthesize the detectable levels of c-Myc1 as assessed by Western blot .
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