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OTAR3088
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BioData-CellLine_annotated

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PMC11640115
The median age was 70 years (range: 37–91).
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PMC9844987
To evaluate the contribution of TF binding site presence for predicting promoter variability, we trained a baseline model based on CpG content status and TATA-box presence only.
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PMC7723249
The analysis of viral RNA inside moDCs showed a similar level of infection between donors for both viruses (Fig 3A and 3B), except the moDCs isolated from donor 1 that showed a higher level of HAZV RNA compare to the other donors (Fig 3A).
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PMC11637716
The need for assisted ventilation, later via tracheostomy, persisted.
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PMC11388384
Medium was identical to that used for NIH3T3 cells, except 10% tet-approved fetal bovine serum (Takara) was used in lieu of cosmic calf serum.
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PMC11676674
No significant differences in the percentage of binucleated cell formation were detected upon treatment with C. monspeliensis extract at different concentrations, and the percentage of binucleated cells formed was 42.83 ± 1.92, 40.31 ± 2.81, and 38.83 ± 2.81 in cells with treated with C. monspeliensis extract at 50, 100 and 200 μg/mL, respectively, compared to NC (40.75 ± 2.29), indicating that C. monspeliensis extract at different concentrations did not affect the cell cycle (Figure 4B).
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PMC6267596
Principal component analysis (PCA) showed concordance among biological replicates and indicated the greatest variance between control vs. treatment groups (Figure 4a and 4f).
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PMC11676674
Detailed analysis steps are shown in Figure 11 (panels a–g) and Figure 12.
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PMC11462673
The chemiluminescence emitted was captured with an AI600 gel documentation system (GE, USA) for image analysis.
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PMC8348645
Different parts of plants containing various bioactive compounds exhibit significant inhibition of cancer .
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PMC11352877
Two such angiopoietins, ANG1 and 2, are deeply involved in angiogenesis .
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PMC11047729
Tocotrienol’s aforementioned activities surpass tocopherol’s, because of the former’s more effective incorporation into the cell’s lipid layer.
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PMC11279598
Extensive scientific and clinical evidence supports the utilization of honey for wounds, skin reactions, and damage to epithelial barriers following radiation treatment and/or chemotherapy .
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PMC10123657
Contaminant peptides may remain in the HPLC-MS/MS analytical instruments after the injection of samples.
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PMC10969097
The decrease in the levels of these cells supports the potential anti-tumoural role of the extracts .
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PMC11684821
Cell surface expression of MR1*01 was enhanced in the presence of K43A compared with K43, which has been reported previously due to neutralization of the positively charged K43, which retains MR1 in the endoplasmic reticulum (Supplemental Figure 5D) (28).
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PMC8973085
The reaction was then allowed to cool before the produced precipitate was filtered, dried, and crystallized in the appropriate solvent to yield compounds 8a–8d.
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PMC9429973
Meaningful improvement in overall health (VAS) was also observed in 50% of patients.
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PMC11790971
b Violin plots show the value distributions of the top 6 most important features.
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PMC11413393
Subsequent pharmacokinetic analysis of drug distribution in serum, kidney, liver, and tumor tissues demonstrated that after three consecutive days of IP injections at 80 mg/kg, residual amounts of the drug could be detected in tumor tissues up to four days later (Supplementary Fig. 10).
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PMC10831439
This protocol allowed a significant expansion of iNKT cells (47.5-fold±9.3 for CD19-CAR-iNKT cells and 95.0-fold±23.1 for untransduced iNKT cells (online supplemental data 1B) with good transduction efficiency (57.7%±5.0%).
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PMC9429973
Methods: A survey of patients with MPN and their treating physicians was conducted from September to December 2020.
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PMC11680391
Researchers such as Kupier et al. (2005) found that the herd veterinarian is an essential partner for the dairy farmer, and we anticipated that the dairy farmer and herd veterinarian would regularly discuss and align expectations regarding udder health consulting.
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PMC11756907
Each experiment was repeated 3 times.
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PMC9143157
All experiments were approved by the Animal Ethics Committees of Sojo University and performed according to the Laboratory Protocol for Animal Handling of Sojo University.
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PMC9429973
CAR-T cells were prepared by lentivirus.
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PMC11345828
The organic layer was dried over MgSO4, filtered, and concentrated in vacuo.
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PMC11320834
p ≤ 0.05, **p ≤ 0.01 Dose–response matrixes of proliferation inhibition after 72 h single or combination treatment with TLLs and OLLs.
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PMC11755519
Effect of extracellular vesicles secreted by bladder cancer cells on bladder cancer cells of other types.
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PMC11752767
The high cost of the production process, resulting from personalized manufacturing procedures, highly specialized good manufacturing practice (GMP) facilities, and trained staff cannot be overlooked.
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PMC11543885
Missed Cleavages: Allow a maximum of two missed cleavages.iv.
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PMC11637284
kDNA, kinetoplast DNA. (
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PMC11470999
These findings suggest that further research into the anticancer efficacies and mechanisms of antipsychotic drugs might provide new perspectives for cancer treatment.
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PMC9927933
Taken together, these results clearly indicate that DEPTOR is indeed a substrate of APC/C, subjected to its ubiquitylation in a manner dependent on the D3-box motif.
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PMC11746948
k n = 860 cancer cell lines.
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PMC11457557
In addition, new genetic analytic methods based on next-generation sequencing technology, in conjunction with gene-environment interaction and pathway-based approach studies, provide a powerful tool for examining the genetic pathways implicated in the development of DVC.
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PMC10033453
From the best-fit curves, the time at which 50% of the maximal cell death occurred could be determined (T50) as a quantitative measure of efficacy between MOIs and across viruses (Figures 2B and 2D).
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PMC11371627
In order to analyse potential pathogenicity of the novel deletion we performed FACS which revealed reduced expression of k antigen in our patient compared to healthy controls.
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PMC10940855
To resolve the precise contributions of EFNB2 reverse signaling and forward signaling in multiple myeloma, we utilized a mutant dEFNB2, which lacks reverse signaling capacity (33).
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PMC11484188
P<0.05 was considered to indicate a statistically significant difference.
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PMC9646302
Moreover, our results demonstrate that RAC1 upstream from MAPK interacts with LAPTM5 (Figures 5(e) and 5(f)).
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PMC11301242
This mechanism is associated with ecDNA structure-induced active histone marks, enhanced chromatin accessibility, and enhancer hijacking.
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PMC11351758
Consistent with the findings in Figure 2, Ca treatment induced toxicity and faster membrane potential depolarization in the Ca-treated NARP cells, especially under high-glucose conditions (Figure 3).
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PMC9581083
This review aims to provide reliable evidence demonstrating the therapeutic efficacy of TCM substances in support of their further development against novel coronavirus infectious diseases in Taiwan.
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PMC11711347
The occurrence of an absorbance peak at 1114 cm confirms the presence of the dithiocarbamate ligand’s C=S functional group .
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PMC11583010
The cell growth inhibitory activity was evaluated in vivo in the SUM190 CDX model and in different PDX models.
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PMC11718031
The culture was started with a viable cell count of 0.5 × 10 cells per mL and propagated at 37 °C, 130 RPM, and 5% CO2 concentration in the incubator shaker for the batch culture experiments.
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PMC7452526
The zeta potential of synthesized CN–Ag was -23 mV, which indicates the high stability of AgNPs.
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PMC11566417
BLMVEC were imaged using a phase-ring microscope.
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PMC10589262
Imatinib mesylate (Sigma) was used as the control drug for GIST treatment.
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PMC11746942
or the solvent control vehicle prior to daily topical IMQ application.
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PMC6684588
Data are means ± SEM (n = 5). ***
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PMC11420784
The bar graph shows the percentage of cells infected with the indicated strains displaying 1 or several NDP52 granules (middle) and the intracellular bacteria that colocalized with NDP52 relative to the total number of cells (right).
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PMC11792766
The S. typhimurium strains used for the assay were TA98, TA100, TA102, TA1535, and TA1537, both in the presence and absence of an external metabolizing system (rat liver S9), as mandated by OECD technical guideline 471.
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PMC11322866
The solid lines indicate direct interactions, while the dashed lines indicate potential interactions.
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PMC8735881
These results indicate that GPI-anchored 10E8 can render CD4 T cells highly resistant to both CCR5- and CXCR4-tropic HIV-1 isolates.
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PMC11088135
This study for the first time reveals the effects and potential mechanisms of lncRNA NUTM2A-AS1 in glioma.
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PMC11727000
We therefore performed karyotype analysis of Usp44 wild-type and -null MEFs after exposure to varying concentrations of MMC.
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PMC10530622
By manipulating external factors, the architecture and biological outputs of the microbiota can be orchestrated to improve human health.
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PMC8382973
Operational taxonomic units (OTUs) were established de novo using UCLUST, and 97% sequence homology was truncated (44).
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PMC9429973
Aims: This study explores whether differential transcriptomic profiles can discriminate between pts with vs without deep MRD remissions, particularly after Ven exposure.
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PMC11670954
The expression of RhoA was significantly increased and translocated to the nucleus, however the expression of ROCK2 around the cytoplasm and membrane also significantly increased.
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PMC11747949
Apart from cancer cells, CCR2 is also expressed in a plethora of cells such as monocytes/macrophages as well as T regulatory cells (Tregs), CD4, CD8 T cells, Natural Killer T cells (NKTs), endothelial cells, μl and fibroblasts (Fei et al. 2021).
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PMC6222726
Savinin (2), also called hibalactone , was isolated for the first time from Juniperus spp. .
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PMC11087055
See also Video 3 and Figure 3—source data 1.
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PMC11185260
A similar trend was observed in blood samples collected on day 56, confirming that fewer adverse effects were triggered when cisplatin was replaced by scL-SMARCB1 in combination with radiation.
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PMC11590870
As for their antioxidant activity, they may act as reducing agents, metal chelators, singlet oxygen quenchers, hydrogen donors, etc.,
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PMC9429973
Aims: We aim to develop a first-in-class inhibitor for hnRNP K and test its efficacy in circumventing resistance of haematological malignancies.
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PMC9352806
Statistical analysis was performed using one-way analysis of variance, followed by Tukey's multiple range test to compare between groups.
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PMC9429973
The median follow-up time of all patients was 8.7 months(0.4~16.1months) and there are 12 patients received 6 ~ 8 cycles of treatment who can evaluate the efficacy.
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PMC11407042
This protocol describes a method for examining T3SS-mediated cytotoxicity in P. aeruginosa using the A549 cell line, which is a straightforward evaluation of the T3SS activity.
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PMC11798926
In experiments where two groups were compared, we used an unpaired t-test, except for the calculation of GM130 and Golgin-97 co-localization where we used a paired t-test.
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PMC9693627
To test this hypothesis, we fractionated mitochondrial lysates by ultracentrifugation in a sucrose gradient and performed Western blot analysis of the resulting fractions with antibodies to PTCD2, MRPS27 (small subunit protein), and MRPL44 (large subunit protein) (Figure 3B).
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PMC11257988
Unlike protein kinases, which have a weak affinity for ATP, KRAS’s binding to GTP or GDP is extremely strong, with an affinity coefficient on the picomolar (10–12) level, while the concentration of GDP and GTP in normal cells is on the micromolar (10–6) level.
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PMC11665555
However, lifestyle complications make bladder-preserving treatments a desired alternative.
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PMC11591052
Therefore, the molecular mechanisms underlying 20E-dependent pleiotropic pharmacological activities in mammals are still enigmatic.
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PMC11740207
These cells are incorporated into developing tissues as OCT4+ cells.
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PMC11377827
PHD3: control vs USP43 siRNA **P = 0.0095, control vs. 14-3-3 siRNA **P = 0.0039.
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PMC9429973
139 CLL/SLL pts were efficacy-evaluable with a median follow up time of 6 months (0.16-17.8+).
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PMC11588085
GSEA of apoptosis pathways in OVCAR3-KRAB cells with sgXIST and sgCtl after hypoxia treatment: Upper panel sgXIST7-H (sgXIST7-Hypoxia) vs. sgCtl-H (sgCtl-Hypoxia), Bottom panel sgXIST9-H (sgXIST9-Hypoxia) vs. sgCtl-H (sgCtl-Hypoxia). (
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PMC9693627
Taken together, these facts allow us to suppose that PTCD2 can selectively regulate COIII translation in human HeLa cell mitochondria.
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PMC10335954
These results suggest that TRIP13 is not only a prognostic marker for GC but also a candidate for future targeted therapy.
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PMC7171147
The tandem mass tag (TMT) labeling and liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis were performed by the Cedars-Sinai Mass Spectrometry and Biomarker Discovery core as described.
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PMC11695623
24 h later, the cell culture medium was collected and the cells were counted.
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PMC10237474
To analyze the glycosylation status of the protein via SDS-PAGE in Fig 1D and S3 Fig, 2.5 μg of protein was deglycosylated using either non-reduced or reduced rapid PNGase F (cat.
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PMC3675084
Our results indicate that BPR0L075 is a potential useful agent in controlling multidrug-resistant ovarian cancer cells.
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PMC11507371
Also, NF-κB translocation was enhanced in A431 cells after prolonged CAP exposure (Figure 5).
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PMC11286266
Following treatment, the cells were lysed in Nonidet-lysis buffer for extracting the cytosolic fraction, as previously described.
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PMC10380508
Batch effects were removed from TPM expression data using the ComBat function from the “sva” R package .
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PMC11593084
Since the first monoclonal antibody (mAb) was approved by the U.S. Food and Drug Administration (FDA) in 1986, a variety of therapeutic antibodies and their derivatives have been developed together with advances in antibody engineering .
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PMC9118379
Variant peptides without the possibility of isobaric substitution or semitryptic cleavage and with multiple PSMs are more reliable.
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PMC5035325
Primary tumor diameters were measured every 2–3 days with a caliper and tumor volume (mm) was determined to the following formula = (minor diamenter) × (major diameter) × π/6.
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PMC9429973
Methods: A total of 1,279 ALL patients were included in the discovery dataset from six publicly available North American cohorts and 767 Australian ALL patients were included as an external validation cohort.
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PMC10999934
Among these pathways, FBXO2 was enriched in protein processing in the endoplasmic reticulum.
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PMC9429973
All country geographic areas were represented.
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PMC11543853
In contrast, it was indicated that minor group rhinoviruses, including rhinovirus 2, release their genomes in late endosomes and translocate them into the cytoplasm through transmembrane pores.
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PMC11087055
It remains unclear how the induced polonaise movements along with the secondary axis overcame the authentic cell flows despite mitotic arrest (Figure 4 and Figure 5).
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PMC4485786
We considered cells representing both innate and adaptive immunity.
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PMC11727062
However, these symptoms have been shown to be mitigated by the co-administration of disulfiram, suggesting that the toxic effects of curcumin can be attenuated by other pharmaceuticals, thereby enhancing its antitumor efficacy (Fontes et al. 2022).
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PMC11394730
A different investigation documented Emodin’s efficacy in treating human non-small lung cancer cell lines A549 and H1299.
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