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PMC9429973
With the goal of developing a lymphoma-matching, humanized model system, we tested the potency of cryo-preserved, human CD34 hematopoietic stem cells to engraft the murine bone marrow niche of immune compromised mice, which are known to take human tumor grafts at high rates, thus, allowing for autologous primary tumor grafts following BM engraftment.
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PMC9429973
Sixteen patients had abnormal thyroid function, including 9 patients with primary hypothyroidism, 1 patient with central hypothyroidism, and 6 patients with subclinical hypothyroidism.
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PMC11185260
Cationic liposome consisting of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP, Avanti Polar Lipids, Alabaster, AL) and dioleolylphosphatidyl ethanolamine (DOPE; Avanti Polar Lipids), referred to as Lip, was prepared as described previously.25 Briefly, DOTAP:DOPE (1:1 molar ratio) in ethanol were injected quickly into 55°C water in a test tube while vortexing.
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PMC11774251
Venn diagram analysis revealed 44 overlapping genes between the targets of Tan-I and those implicated in psoriasis (Supplemental Figure 1A), which represents a significant finding of this study.
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PMC11345828
As previously reported, introduction of the 1,3,5-trimethylpyrazole substituent on the core indole generates an ortho–ortho′-substituted biaryl C–C bond with hindered rotation and no selectivity over the resultant axial stereocenter.
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PMC11055323
By deletion analysis, we show that its C-terminal disordered region is both required and sufficient for exclusion by SS18-SSX condensates (Supplementary Fig. 8b).
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PMC11472639
Thus, when added to a 200 μL well, the concentration of PBMCs within 200 μL was equivalent (i.e., 100%) to that observed in the circulation in vivo and therefore twice as much as the whole blood conditions in our assay.
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PMC11317131
To measure expression and export of recombinant vWF protein, HEK293T cells were seeded in 6-well plates and the next day were transfected with 1200 ng of PE5max, 120 ng of each epegRNA plasmid, 480 ng of helper plasmid, 480 ng of donor plasmid and 240 ng of DsRed expression plasmid (for sorting).
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PMC11577421
Subsequently, NPs coated with both PCX-loaded BSA and BSA+ were prepared and purified similarly as described above.
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PMC11787355
Upon PTPRZ1-TCR-T treatment, malignant cell frequency was decreased (Fig. 6c), and average PTPRZ1 expression in malignant cells was lowered (Fig. 6d).
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PMC11792766
Mean cytotoxic effect of ethanol to HepG2 and Caco‐2 cell lines following 24 h of exposure as determined via the lactate dehydrogenase (LDH) assay.
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PMC11548041
Cholesterol-modified constructs can be incorporated into the MNV membrane due to the amphiphilic nature of their membrane.
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PMC11609529
A few representative YAP1 target genes were indicated. (
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PMC10940855
As a model to understand how ECs regulate multiple myeloma growth, we cocultured the human multiple myeloma cell line, U266 (ATCC), with different sources of human ECs.
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PMC9429973
Efficiency of condition regimens.
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PMC11670954
.
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PMC11409031
Following the outcomes of Harmony, the RunUMAP function was employed for Unified Manifold Approximation Projection (UMAP) dimensionality reduction, while the FindNeighbors and FindClusters functions were utilized for neighborhood search and clustering analysis to understand the data structure.
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PMC10713411
Network diagram of the correlations between PRPCDGs’ expression and its highly correlated KEGG pathways. (
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PMC11697189
We assessed differences in the distribution of somatic mutations between groups, with higher somatic mutation rates in the high-risk group (84.25%, 107/127) than in the low-risk group (77.56%, 159/205), and the 20 most frequently mutated genes were listed (Fig. 8A-B).
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PMC11155445
In the search of a new potent drug for enterovirus infections, Liu et al. found that 4-(tert-butyl)-N-((4-(4-(tert-butyl)benzamido)phenyl)carbamothioyl)benzamide (110) display prominent inhibitory activity against EV-A71, EV-D68, CV-A21, CV-A16 and CV-B1 and inhibiting proliferation of enterovirus based on intermolecular interaction like H-bonding, hydrophobic interaction and π–π stacking (Fig. 44).
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PMC10568263
Another reason may be due to the existence of defects in the crystal plane of MoS2 nanosheets.
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PMC11438317
Then, 105 μL phosphatase buffer with 2 μL of 3xFLAG-R or W. Tubes were incubated at 37 ºC and aliquots of 24 μL were taken at 0, 5, 15 and 30 min and mixed with 8 μL of 4 × Laemli buffer.
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PMC6600592
SPSS 20.0 and MICROSOFT EXCEL 2010 were used for the statistical analysis.
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PMC9429973
Risk factors were increasing BMI and BSA in addition to therapy-related AML and favorable cytogenetic risk.
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PMC11674441
Control genomic DNA was obtained from patient-matched PBMCs.
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PMC11711345
Nevertheless, no families were attributed predominantly as one preferential path.
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PMC11343332
Treatment with pycnogenol at a concentration of 80 μg/mL significantly inhibited the migration of breast cancer cells compared to the control group.
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PMC11391695
Scale bar: 200 μm; *p < 0.05, **p < 0.01, ***p < 0.001 ACYP2 inhibits HCC cell proliferation and metastasis in vitro.
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PMC11544122
Fig. 6e and Supplementary Table 1).
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PMC10482220
This fully supports the idea that SGs are the sites where mRNA fates are determined during stress (Kedersha et al., 1999, 2002).
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PMC10092581
Consistently, treatment of H157 cells with either Au(I) or Ag(I) complexes determined a substantial time‐dependent increase in cellular basal ROS production (Figure 4, panel B).
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PMC10882807
RIP Kit (Geneseed, China) was used to perform RIP assay.
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PMC11684269
ACLY orchestrates the interconnection between glucose metabolism and de nove lipogenesis by catalyzing the formation of cytosolic acetyl coenzyme A (AcCoA) from mitochondria-released citrate (43).
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PMC9776316
Images were acquired using LEICA confocal microscopy.
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PMC6835428
Verified the favorable retention of DFP-10825 in the ascitic fluids, the authors tested the efficacy and found that the IP injection of DFP-10825 (0.5–2 mg/kg every third day) resulted in a time- and dose-dependent reduction of tumor mass.
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PMC10047551
The tumor milieu operates through the production of cytokines and IFNs, e.g., T-cell-produced IFN-γ, determining the PD-L1 expression level, in addition to the effects of oncogenic signaling pathways .
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PMC11683240
Cells were left untreated as further control (Con) or incubated with AT and Fon only.
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PMC11392912
The concentration of miRNA in the blood also depends on the half-life of plant miRNA in blood, which ranges from ≈ 1.5 h to more than 13 h and may also affect Clo-miR-14 concentration after consumption .
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PMC10758402
Individual statistical tests were detailed in figure legends.
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PMC6627640
In order to explore mechanisms of cisplatin resistance in testicular cancer cells, RNA-seq transcriptomic profiling and differential gene expression analysis was performed on 10 randomly chosen resistant lines.
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PMC11686380
Knockdown of exogenously expressed GAP43 in COS7 cells.
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PMC9429973
2.
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PMC11541241
Moreover, some studies found that Arabidopsis TOR overexpression plants exhibited increased susceptibility to P. syringae pv.
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PMC11665555
Resistant orthotopic tumors presented an OXCT1-dependent rise in mitochondrial oxygen consumption rate, ATP, and nucleotide biosynthesis.
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PMC11666785
As the signals are captured from a same focal plane, so it is possible to correlate the PSF which repeats in the consecutive frames.
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PMC9621239
The HBV genome contains four open reading frames (ORF), among which the ORF X encodes HBV X (HBx) protein.
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PMC9100622
Then, the cells were centrifuged and permeabilized with 0.2% Triton X-100 for 20 min.
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PMC11089031
After deparaffinization, IHC staining was performed using an anti-ZNF692 antibody (Bioss, Beijing, China, Cat: bs-4360R) and horseradishperoxidase (HRP) conjugated second antibody (Beyotime, Beijing, China, Cat: A0208).
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PMC9429973
The absolute risk of COVID-19 related mortality was 0.45% among patients treated with ASCT.
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PMC11738017
For CME questions, see page 2683.
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PMC11476004
Cytogenetics deals with the analysis of the constitutional karyotype and with chromosomal abnormalities, e.g., the detection of chromosomal aberrations associated with the tumour and other types of instabilities.
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PMC9672323
The effect of two different concentrations of dexamethasone (a) and piroxicam (b) on the proliferation of T cells in PBMCs was compared in stimulated and non-stimulated conditions (n = 3).
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PMC9424261
From gene and protein levels, we showed that CA increased the sensitivity of liver cancer cells to ferroptosis by upregulating HERPUD1.Fig.
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PMC10154881
Flow cytometry was performed using the BD FACSVerse system or a Attune NxT Acoustic Cytometer (Invitrogen).
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PMC11453018
Note that iP300w and EWS::FLI1 knockdown both affect the cell cycle and induce cell senescence To assess the dependency of EWS::FLI1 transcriptional activity on P300/CBP, we compared transcriptional alterations following EWS::FLI1 knockdown (48 h) and P300/CBP inhibition (4 h).
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PMC9516447
While the precise mechanisms remain to be determined, cellular stress is reported to function in synergistic cooperation with oncogenic mutations including mutant RAS to drive cancer progression by enhancing the ability of cells to tolerate these stresses through multiple mechanisms .
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PMC11128598
Tumor cell lines carrying the HR reporter cassette were pre-treated or not (C-) with LBH for 24 h and then co-transfected with 5 μg of an I-SceI endonuclease-expressing plasmid and 0.5 μg of pDsRed2-N1.
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PMC11703992
Using Jurkat cell line, the function of DDIT4 was further explored in experiment level.
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PMC11297139
AT-rich interactive domain-containing protein 1A (ARID1A) is a chromatin remodeling factor frequently associated with cancer mutations, yet its functional mechanism remains largely unknown.
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PMC11736898
As with keloid disorder, an inverse correlation between vitamin D status and severity of atopic dermatitis has been reported ; oral supplementation with vitamin D to improve vitamin D status in atopic dermatitis patients was associated with an increase in expression of VDR, as well as CAMP, in skin lesions .
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PMC10854447
The inhibitory effects of the most potent antiproliferative derivatives 7h–l on EGFR, as a possible target for their antiproliferative action, were investigated using Erlotinib as the reference drug.
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PMC11545868
It decreased carcinoembryonic antigen (CEA) and related metabolites .
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PMC11190538
The blood was mixed with an equal volume of sterilized Alsever solution (2 % dextrose, 0.8 % sodium citrate, 0.05 % citric acid, and 0.42 % NaCl in water).
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PMC10582049
GO enrichment analysis indicates that the ADH1B subpopulation also has been involved in the deposition and remodeling of ECM structures (Fig. 3B).
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PMC11001582
Graph, mean ± s.e.m.;
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PMC9429973
Intolerant pts must not have achieved MMR at baseline visit.
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PMC11307990
These 6HB-DONs were assembled from a 7249-nucleotide-long M13 bacteriophage genome DNA and multiple short single strands through a single-step annealing process.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "6HB-DONs", ...
PMC6892818
Expression was compared to HCT116 (CD40 positive) and SW480 (CD40 negative) colorectal carcinoma (CRC) lines.
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression"...
PMC9429973
Moreover, we expanded a single HSC over multiple cell divisions using our culture system to demonstrate bona fide HSC self-renewal potential of the rMSC-based system.
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PMC11742864
However, the influence of inflammation on most cancers is double-edged.
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PMC11335267
Consequently, overexpression of Pck1 in adipocytes results in obesity .
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PMC10454535
Further research of this treatment as well as other novel drug combinations is essential for the identification and application of optimized drug treatments that provide the most benefit to patients.
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PMC11098378
Indeed, expression of Flag-tagged wild-type Ceg10 significantly enhanced the replication of all four arboviruses.
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PMC11411131
Luminescence was monitored using a Luminescencer system (ATTO, Osaka, Osaka, Japan).
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PMC11216402
To reduce noise, RNA-seq analyses were performed using 11,312 “tissue-specific” genes, which are derived from GTEx RNA-seq profiles of 54 healthy human tissues (GTEx portal: GTEx_Analysis_2017-06-05_v8_RNASeQCv1.1.9_gene_median_tpm.gct.gz).
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PMC11672602
M, N) Immunohistochemistry studies of bcl2 in DMBA induced mammary gland model.
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PMC9065483
Quantification by qPCR revealed that the addition of gefitinib negated increases in proinflammatory IFNβ, IL-1b, IL-6, TNF-ɑ and CCL5 mRNA levels induced by vanadate (Figure 4F), all of which are in part stimulated by NF-κB. Moreover, one of the most striking phenotypes of tumor cells treated with vanadate in combination with VSVΔ51 is an increase in the transcription of T cell chemoattractant chemokines, namely the IFN-2-induced chemokines CXCL9 and CXCL10.
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PMC8389560
Molecules that induce apoptosis through gap junctional communication are Ca, IP3, and cAMP ions, with the ultimate target of caspases and the opening of mitochondrial permeability transition pores .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11775197
Despite significant advancements in the diagnosis and surgical treatment of CRC, the occurrence of metastasis and recurrence continues to reduce patient survival rates .
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PMC11634794
Colon cancer cells with strong metastatic ability express higher levels of LAMP1 protein on their surface, and it has been demonstrated that LAMP1 binds to E-selectin through terminal sialylated Lewis oligosaccharide -X (SLeX), promoting colon cancer cell metastasis (30).
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PMC11519583
Colors span a gradient from blue (high expression) to gray (low expression).
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PMC11792888
All cells were maintained in Dulbecco's modified Eagle's medium, 90% (w/v) with heat-inactivated fetal bovine serum (FBS), 10% (v/v), penicillin (100 U/mL), streptomycin (100 μg/mL), and fungizone (100 μg/mL).
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PMC9429973
Prospective clinical trials are needed to verify our results.
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PMC10545062
Given the complexity of this nascent field, limited human research in this area has largely focused on only a single intervention at a time.
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PMC11715644
We calculated the difference in between outside and inside channels ( averaged over the last 6 hours of imaging), which indicates the degree of sensitivity for confinement by a given cell type (Fig. 3H).
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PMC11699042
Significant differentially methylated CpG probes were extracted with the decideTests function of the limma package with an FDR < 0.05 (Benjamini-Hochberg).
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PMC7351993
The insets show representative SRS images of cells in the sort (n = 108) and unsort regions (n = 11,068).
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PMC6948907
Another study has reported that GE can inhibit tumorigenesis through epigenetic control in several cancer cell lines (Li et al., 2013; Li et al., 2009) and induce a chemopreventive effect against various types of cancer cells, including cancer of prostate, colon and esophageal cancer (Barnes et al., 1995) by demethylating activity leading to reactivation of methylation-silenced genes (Fang et al., 2007).
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PMC9429973
: p. 379-386.
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PMC11734514
1.53e (NIH).
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PMC7987994
This could also lead to discrepancies.
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PMC11577421
Taken together, our results suggest that strategically exploiting albumin-GAG interactions could offer a novel approach to optimize ABNP systems.
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PMC11718817
The role of these APCs remains a matter of debate.
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PMC9429973
E. Uppal, J. Khwaja, A. Rismani, C. Kyriakou, S. D’Sa Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom Background: Waldenström macroglobulinemia (WM) is an indolent lymphoma with a prolonged disease course which typically follows a remitting and relapsing trajectory, eventually leading to treatment resistance.
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PMC11366496
Li et al. reported that glioma progression is facilitated by regulating the MZF1/c‐Myc/HIF1‐α axis through the presence of Linc01060 in exosomes derived from hypoxic glioma stem cells.
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PMC11786767
B: The knockdown effect of Ki67-miR. Whole-cell extracts were collected and immunoblotted with Ki-67 antibody to detect endogenous Ki-67 protein levels.
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PMC6450504
To investigate the ability to downregulate a target protein in MDR cancer cells, PEIPOS were complexed with anti-P-gp siRNA (siMDR1).
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PMC11643491
The films were mounted on an axial stretcher comprised of two aluminum blocks mounted on a screw, which when turned separated the blocks, and the films were stretched in hot oil, a hot oven, or toluene.
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PMC7642379
For instance, the suspension progeny cell lines had a significant up-regulation of gene sets involved in cellular compartment organization such as cell morphogenesis, cell junction-, cell membrane- and cytoskeleton organization.
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PMC10604092
The data are expressed as mean ± standard deviation.
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