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PMC9429973
NGS-based approaches allowed for the detection of PAX5 P80R, IKZF1 N169Y and ZEB2 H1038R and fusion partner genes.
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PMC10772747
Over a period of 24 hours, T47D cells were treated with Eleutherine bulbosa, doxorubicin and 1,4 naphthoquinone at various concentrations, and cell survival was evaluated using the MTT assay.
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PMC11787355
Nevertheless, more glioblastoma-reactive TCRs should be developed to expand the HLA coverage and to allow multivalent cell therapy, preventing escape through antigen loss.
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PMC9429973
The cumulative incidence of aGVHD of grade II-IV was 25.1%, the cumulative incidence of grade III-IV aGVHD was 12.4%, the cumulative incidence of aGVHD in 27 standard-risk patients was 48.1%, and the aGVHD in 75 high-risk patients was 43.4%; 97 evaluable patients, 49 patients developed cGVHD, the 3-year cumulative incidence of cGVHD was 55%, the cumulative incidence of localized cGVHD was 46%, and the cumulative incidence of extensive cGVHD was 14.3%.The 3-year cumulative recurrence rate was 27.1%.
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PMC11756907
Data were analyzed with GraphPad Prism Software version 8.0.1 using bidirectional ANOVA with Tukey’s multiple comparison tests; **p < 0.01, ****p < 0.0001 versus control.
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PMC11753541
The authors have been using this autoclaved steel box as an incubator for more than a decade.
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PMC11258145
To assess the biological action of curcumin, cells were exposed to different concentrations of curcumin (5, 10, 20, 30, 40, 50 μM) for 24 h (as seen in Fig. 4).Figure 4The cell viability determined by MTT assay.
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PMC11536589
The expression levels of CTNNB1 in ductal cells of untreated mouse (Control and Vehicle) and of mouse treated with MRTX1133. (
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PMC2944824
Mitochondria and ER stress induce the intrinsic apoptotic pathway that involves the opening of the outer mitochondria membrane pore resulting in the release of cytochrome C and subsequent activation of caspase 3.
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PMC9429973
Methods: The present study was a cross-sectional study of adult patients who visit our anticoagulation clinic and receive anticoagulant therapy for more than 1 year after DVT, PE or AF.
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PMC11705630
Glycine decarboxylase (GLDC) is a part of mitochondrial complex enzyme, glycine cleavage system (GCS).
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PMC3675084
The cell cycle profiles are presented as three-dimensional overlay.
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PMC9429973
CR and objective response (OR) rates were 33% and 75%, with 31% of OR-evaluable pts with abnormal cytogenetics at BL having cytogenetic CR.
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PMC11741577
and **** indicate P < 0.05 and < 0.0001, respectively). (
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PMC11128598
To analyze whether ROS generation was also crucial in triggering apoptotic cell death in other tumor types, the different cell lines were treated with CQ, LBH or their combination in the presence or absence of N-acetylcysteine.
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PMC11693599
Therefore, the quantification of CSC-secreted CD109 protein may be applicable for the diagnosis and prognosis of patients with ovarian cancer.
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PMC11705547
Cisplatin can also activate CTLs by promoting infiltration of antigen-presenting cells (APCs) , and increasing production of type I IFN and IL-6 .
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PMC11594588
Fe ions play an important role in the regulation of many cellular pathways.
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PMC11301095
Its natural habitats include hot springs, ponds, rivers, and freshwater lakes.
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PMC11306331
Cells to be infected with lentivirus were plated at 30% confluence in a 6 well plate and 500 μL of virus solution, 50 μL of 1 M HEPES, and 1 μL of 5 μg/mL polybrene (Sigma Aldrich) were added.
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PMC11496491
CXCL5 and CXCL6 differentially up-regulated genes are involved in the process of neovascularization, and HLA-DRB1 is involved in the improvement of the degree of diabetic peripheral nerve degeneration.
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PMC11470999
After incubating recombinant CIP2A protein (1‐560), His‐VHL, and different concentrations of PF in vitro, His pull‐down assay was conducted.
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PMC11768927
In mouse models of prostate cancer, both intratumoral and intravenous administration of VSV-GP led to long-term remission.
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PMC11741577
After they were washed with PBS, an avidin–biotin–peroxidase complex was added, washed again, and added with the HRP substrate (TMB).
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PMC11758416
Centrifuge the T cells at approximately 450 × g for 5 min at 4°C.d.
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PMC6163708
GANT61 killed the sensitive cells through apoptosis.
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PMC11612626
MMCLs were treated with compound A and the effect on pan- and individual HLA allele levels probed by antibody-specific staining and flow cytometry.
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PMC10993311
Mas-Parés et al. (2023) validated the main methylated CpG loci using pyrosequencing and demonstrated an association of SETD8, SLIT3 and RPTOR methylation with gestational weight gain, with higher levels of SETD8 and RPTOR methylation being associated with a higher risk of obesity in the offspring.
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PMC11407042
The data presented in Figure 1A shows the absorbance measured at step 31 for the negative/positive control groups and the A549 cell culture groups after infection by P. aeruginosa PAO1 wild-type, ΔfleR, and ΔfleR(fleR) strains.
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PMC10047551
No increase in PD-L1 mRNA expression was observed following treatment of the HCC827 cells with AZA; instead, a minor decrease in expression was observed (Figure 3D).
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PMC11794568
Mitochondria were labeled using Mitotracker (Red).
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PMC9776316
However, the specific inhibitor of XRCC4 is not commercially available to our knowledge; the possible target strategy could be the inhibition of the JNK-cJUN pathway to control the level of XRCC4.
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PMC9429973
CLL-CI score was associated T cell phenotype in this study.
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PMC4443654
Similarly, for H1 compartment boundaries, 37% have a matching boundary in the same or an adjacent 100-kb bin in GM12878 (K562: 35%, null model: 7%; Kolmogorov–Smirnov test: D=0.47, p≈0, Additional file 1: Figure S2A).
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PMC5311252
After harvesting of cells, genomic DNA was isolated using QiaAmp kit (Qiagen) according to the manufacturer's protocol.
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PMC5925824
Panel a: CLUSTALW multiple sequence alignment of domain 1 of human (hu-PD-L1), canine (ca-PD-L1), and murine (mu-PD-L1) PD-L1 and human PD-L2 (huPD-L2) to identify LY3300054 a subset of the specificity anchors on hu-PD-L1.
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PMC11525028
Red dots indicate upregulated genes, red dots with borders indicate oncogenes in osteosarcoma, blue dots indicate downregulated genes, and blue dots with borders indicate tumor suppressors in osteosarcoma.
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PMC11628904
Burns were performed until the wounded region reached halfway to the posterior notochord boundary to avoid damage to the notochord.
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PMC11591794
Especially in the GA+DOX group, the P53 level increased to the maximum, while Bax increased the most in the DOX group (Figure 5).
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PMC10631132
Both cell lines underwent mesodermal induction at passage 27.
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PMC5673955
In order to determine the ability of RrA to inhibit telomerase directly, RrA was added to lysates of Jurkat and CD4 T cells, and TRAP assay was performed.
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PMC9429973
The case illustrates that pretreatment factors, including patient inflammatory state and tumor volume may determine CAR T outcome in this setting.
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PMC9000591
However, there has been no research on phytochemical profiles related to cytotoxic potentials of C. speciosa against multiple types of hematological cancer.
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PMC11512230
They can act as adjuvants in cancer immunotherapy and can be used as drug delivery systems for cancer cells.
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PMC11591038
In contrast, however, ample evidence also indicates that HIF-1α inhibition might exert a beneficial effect on AD.
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PMC10213199
After removing the supernatant, the RNA pellet was washed twice with 1 mL 75% ethanol, and the mixture was centrifuged at 12 000 g for 3 min at 4 °C to collect the residual ethanol, then air dried for 5–10 min in a biosafety cabinet.
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PMC10482220
G3BP is recruited to SGs. (
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PMC11796104
Among these circRNAs, novel_circ_0014940 and hsa_circ_0002484 were the most up-regulated and down-regulated DEcircRNA, respectively (Table 3).
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PMC11643361
Copper and ruthenium scorpionates show promise, leveraging redox activity and mitochondrial disruption mechanisms to selectively induce cancer cell death.
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PMC9429973
Results: At data cut-off (February 22, 2022), 21 pts were enrolled with a median follow-up time of 6.5 months.
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PMC9429973
However, we have seen differences also in the metabolism and growth of the ERCC6L2-deficient patients’ skin fibroblasts.
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PMC9429973
Methods: In 176 de novo FLT3-ITD AML patients who were treated in HOVON-SAKK multicenter prospective phase III clinical trials, NGS was performed at diagnosis and in complete remission (CR) following two cycles of standard induction chemotherapy.
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PMC11545737
The classical pathway relies on inflammasomes, cytosolic protein complexes consisting of (i) NLRs or PYHIN family proteins, (ii) the apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) adapter protein and (iii) procaspase-1 .
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PMC9429973
Conditioning regimens: CLV (cyclophosphamide, lomustine, etoposide) – 78 patients, LEAM (lomustin, etoposide, cytarabine, melphalan) – 129 patients, BeEAC (bendamustine, cytarabine, etoposide, cyclophosphamide) – 72 patients.
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PMC11610461
The tissue samples were fixed with formaldehyde and embedded in paraffin wax, and then sliced by microtome (Ma et al., 2021).
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PMC9429973
Agreement between methods was 87%.
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PMC11592008
In contrast, the expression level of GSDMD was highest in the HaSKpw cell line and low in the PK cell line (Figure 1D).
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PMC11783017
Additionally, previous study has reported the role of Mn in activating the STING pathway .
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PMC11155445
The sequence of the inhibitory effect of different substituents on benzene ring at the para position was OMe > Cl > t-butyl > methyl.
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PMC11519077
The MMP9 gene expression in the MB-MSC (6.17 ± 0.879; p < 0.001) and MB-CM (10.53 ± 1.308; p < 0.001) groups has dramatically increased as compared to the control group.
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PMC9895440
e Average expression of selected marker genes (color).
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PMC9429973
Intronic regions of this apoptosis-related gene are included in several circRNAs, augmenting the repertoire of miRNAs predicted to be bound by BCL2L12 transcripts.
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PMC10114490
diHLC-T, n = 6; HepG2, n = 3; *p < 0.05, **p < 0.01,***p < 0.005) diHLC-T outperform HepG2 cells in toxicometabolomic testing.
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PMC9429973
Currently, 820 patients are enrolled.
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PMC11796104
Total RNA was extracted using Trizol reagent (Sigma) and quantified with a nucleic acid protein analyzer (Biospec-nan).
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PMC11740399
First, although compound 3K and 3025@ML decrease the accumulation of FASN and significantly enhance the anti-tumor activity of OXA, further study still needs to clarify how PKM2 regulates the expression of FASN.
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PMC11591030
In contrast, the LPS + AOP-treated PBLs mitigated these effects by decreasing the oxidative stress markers, increasing the antioxidant enzyme activities, and enhancing the gene expression of Nrf2 and its downstream targets.
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PMC5261804
Comprehensive analysis of drug sensitivity correlations was performed by comparing the strength of correlations for two sets of drug/PPI pairs: 1) drug/PPIs pairs where the PPI involves a protein targeted by that drug and 2) PPIs involving no known target protein.
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PMC9429973
The heterozygous FXIII 34 Val/Leu variant was underrepresented in DVT group (32.9% vs. 47.7% in CG; OR=0.5; 95% CI: 0.3–0.9; p=0.03), whereas the genotype FXIII 34 Val/Val was prevalent among DVT patients (61.8% vs. 47.1% in CG; OR=1.9; 95% CI: 0.9–3.1; p=0.03).
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PMC10996034
Although ovarian cancer has a lower incidence rate than endometrial cancer, with 313,959 new cases in 2020, it is associated with a high mortality rate of 207,252 cases, ranking it third among all gynecological malignancies (1).
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PMC11720808
Quantification and normalization of p65 bands shown in (D) were performed relative to corresponding internal markers. (
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PMC8922418
It is performed by transplanting gene edited hematopoietic stem cells (HPSC) or CD4 T cells derived from the bone marrow cells or peripheral-blood mononuclear cells (PBMC) of HIV-1/AIDS patient.
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PMC9429973
Similar to conventional CD19-directed CAR-T, they exhibited potent CD19-specific cytotoxicities both in vitro and in vivo.
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PMC11612508
These peak values are in close agreement with the values reported by Kim et al..Fig. 3FTIR pattern of pattern of (A) Fe3O4 magnetic NPs and (B) GO nanostructures and (C) the magnetic microspheres.
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PMC11155445
Among cobalt complexes compound TH05-Co(ii) had good antioxidant potential with an IC50 value of 11.4 ± 0.2 μg mL comparable to standard ascorbic acid (IC50 10.8 ± 0.5 μg mL).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11438317
Then, we tested whether LYP could prevent the activation induced by racQL, a dominant active mutant of the small GTPase rac that is activated by Vav in T cells .
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PMC9428827
Treatment schedule. (
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PMC11770199
Two cells were digested and mixed 5 h after transfection.
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PMC11659921
Initially, we ranked the similarity of the seven prognostic genes using Friend analysis, which revealed that TNFSF11 is the most critical gene among them (Figure 7A).
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PMC9105697
Mutations which are described as pathogenic, e.g., in COSMIC (https://cancer.sanger.ac.uk/cosmic, (accessed on 16 October 2019)), were included in the patient’s individual exome panel together with the mutations identified in the subtype-specific panel, resulting in 18 targetable mutations.
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PMC11469524
Phosphorylation of S338 increases slightly after BCR activation, however, there is no effect by p38 inhibition.
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PMC11637284
Sequences of TAC60 and p166 orthologs of Kinetoplastids were obtained from the TriTrypDB database .
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PMC4360730
For example, although the RNA population being sequenced may be polyadenylated-RNA or total RNA, both experiments will be annotated to the RNA-seq assay.
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PMC11756907
At the same time, solutions of 2-methoxyestradiol (2-ME, Selleckchem) were prepared with a concentration of 1 mg/mL in ethanol and dimethyl sulfoxide, respectively.
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PMC11705862
The purity of fractions were assessed with specific antibodies form disulfide isomerase (PDI), specific for membranes, and β-tubulin, enriched in cytosolic fraction.
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PMC11352311
Significant MFs were related to protein serine/threonine kinase activity, ATP binding, and protein binding.
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PMC9429973
S. Usmani, A. Hoering, S. Ailawadhi, R. Sexton, B. Lipe, J. Valent, M. Rosenzweig, J. Zonder, M. Dhodapkar, N. Callander, T. Zimmerman, P. Voorhees, B. Durie, S. V. Rajkumar, P. Richardson, R. Orlowski Memorial Sloan Kettering Cancer Center, New York; Cancer Research And Biostatistics, Seattle; Mayo Clinic, Jacksonville; University of Rochester Medical Center, Rochester, NY; Cleveland Clinic, Cleveland; City of Hope, Los Angeles; Karmanos Cancer Institute, Detroit, MI; Emory Winship Cancer Institute, Atlanta GA; University of Wisconsin, Madison; Beigene, Chicao; Levine Cancer Institute, Charlotte; Cedar Sinai Medical Center, Los Angeles; Mayo Clinic, Rochester MN; Dana Farber Cancer Institute, Boston MA; MD Anderson Cancer Center, Houston TX, United States of America Background: The introduction of immunomodulatory agents, proteasome inhibitors, and autologous stem cell transplantation (ASCT) has improved outcomes for patients with multiple myeloma (MM), but those with high risk MM (HRMM) have a poor long-term prognosis.
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PMC11779993
Treatment with SPEE (50 and 100 μg/mL) increased FAK and Src phosphorylation in western blotting.
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PMC10850553
Up-regulation of C5ar1 in the selective mTOR inhibitor Torin1 treated-NIH3T3 cells.
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PMC11698348
Interestingly, we observed opposing effects after loss-or-gain of Elf5 functions in epidermal SCs compared to HF SCs (Fig 2). (
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PMC11638764
To explore the pathways associated with downregulated proteins, we compared pathway changes across the CER, NER, and INS compartments ( Fig. 1I –K).
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PMC11545737
Pyroptosis disruption of tight junction increases the epithelial permeability and aids bacteria to cross the epithelial barrier.
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PMC7602170
For imatinib-resistant GIST patients, the tumorigenesis mainly involved in the heterogeneity of KIT secondary mutations , and targeting KIT, is limited by its susceptibility to multiple mutations .
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PMC11711935
Attention to skin pigmentation disorders, including hyperpigmentation and hypopigmentation, has increased.
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PMC11564322
In turn, in the MEG-A2 cell line, both peptides decreased the mTOR protein expression, and the c-SRC inhibitor did not influence changes caused by the tested peptides.
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PMC11754432
Western analysis (E) of total and phospho EGFR (Y1068) relative to control siRNA (N = 5).
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PMC11775197
Seetha and his colleagues found that the combination of indomethacin and juglone reduces the expression of inflammatory cytokines through the Wnt, Notch, and PPARγ pathways, thereby inducing apoptosis in colon cancer cells .
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PMC10142392
The combination of these two processes yielded well-defined copolymers across a broad range of compositions.
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PMC11742864
The potential mechanisms are: 1) ω-3 LCPUFAs and their metabolites participate in and regulate lipid peroxidation and induce mitochondrial damage in neoplastic cells; 2) ω-3 LCPUFAs and their metabolites, as ligands, bind to nuclear receptors such as peroxisome proliferator-activated receptors (PPARs) to regulate pro- or anti-oncogene expression and induce chromosome damages; 3) ω-3 LCPUFAs and their metabolites regulate protein kinase C (PKC), nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways.
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PMC11388384
Only the molecules in free population were allowed to jump across cell boundaries.
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