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OTAR3088
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BioData-CellLine_annotated

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PMC9019892
GIST‐882 and GIST‐48B cell lines were cultured in IMDM (Gibco by Life Technologies, Carlsbad, CA, USA) with 10% FBS (GIBCO).
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PMC7334607
Comparing these two plots shows the clear divergence in drug response between experimental and control evolutionary replicates as the treatment regimen continued.
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PMC11740508
However the study showed minimal anti-tumor efficacy , which would be predicted from our studies in tumor models with intact HRR status.
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PMC5173112
Based on these results, we sought to further define the role of USP21 in regulating CSC property in RCC cell lines. (
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PMC9429973
The TP53 gene mutation is observed in approximately 10-15% of newly diagnosed AML and is associated with poor survival.
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PMC9046263
We sought to identify locoregional differential expression of endogenous retroviral elements, tumor suppressors and oncogenes in gliomas.
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PMC10589262
The primary mutations are mostly detected in exon 11 of KIT, and patients with these mutations show more than 80% of the overall response rate (ORR) to imatinib .
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PMC9429973
COVID-19 naïve patients treated for CLL demonstrated significantly lower serological response early after the 2nd dose (median 0.08 vs 2.2, P<.001) as well as in long-term follow-up (median: 0.21 vs 2.86, P<.05) than untreated COVID-19 naïve patients.
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PMC9429973
Results: Trial in Progress.
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PMC7812570
To this end, GPI-m36.4- and GPI-FluIg03-transduced TZM-bl cells were costained with (i) a mouse anti-His tag antibody, followed by an Alexa Fluor 488-conjugated goat anti-mouse IgG antibody, (ii) Alexa Fluor 555-conjugated cholera toxin subunit B (CtxB), which can interact with the lipid raft marker GM1, and (iii) 4′,6-diamidino-2-phenylindole (DAPI).
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PMC10698968
Ribosome biogenesis is a well-known indicator of cellular replication .
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PMC11551844
For non-treated (NT) cells, DMSO was added at a final concentration of 0.4% (v/v) as a solvent vehicle control.
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PMC9429973
For patients who achieved CR/CRi and did (n=10) or did not (n=29) proceed to subsequent alloSCT post–KTE-X19 infusion, the median (95%CI) DOR was NR (NE-NE) and 14.6 months (8.7-23.6), and the median (95% CI) OS was NR (7.6-NE) and 26.0 months (18.6-NE), respectively.
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PMC11638288
Furthermore, the inhibitory effect of neutralizing antibodies against NKp46 significantly reduced the cytolytic activity during co-culture with transfected cells.
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PMC11129910
As the level of overexpression of the oncogene increased, cells had a higher tendency to undergo transformation.
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PMC10831439
Annexin V/VD gates were set on singlets and CTV+ cells. (
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PMC11711347
The stock solution of Ni(II)ProDtc was diluted to eight concentrations ranging from 2.34 to 300 µg/mL in eight 1.5 mL microtiter plates, each labeled with respective concentrations.
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PMC9429973
Among NPM1mut AML patients, FLT3-ITD and ELN 2017 categories retained its prognostic value in the early cohort, with a worse OS, EFS, and higher RR among FLT3-ITD vs wt patients (HR for OS 1.9 95% CI 1.15-3.2, p=.011; figure 1C) and FLT3mut ELN-intermediate vs favourable patients (OS p<0.001; figure 1D).
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PMC11486946
A DNA construct linking the cDNA of human EGFR (Supplementary Data 3, provided by Akihiko Yoshimura, Keio University) to the pEGFP-C1 vector (Clontech, Japan) was transfected to parental CHO-K1 cells with 80% confluency in a 6 cm dish using FuGENE HD (Promega, USA) with 2 µg of the construct mixed with 500 µL of OptiMEM (31985-062, Gibco, USA).
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PMC9429973
Given the low incidence of the disease the cooperation of centers at international level is necessary.
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PMC8409415
Thus, the expression of CD70 was compared before and after NACT in six patients (Table S2).
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PMC6600253
These molecular events can induce a transient proliferation arrest that can evolve into senescence if cells are not able to repair the damage.
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PMC11765879
The half-maximal inhibitory concentration (IC50) for the different treatments in each cell line was calculated using the linear equation of the resulting scatter plot.
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PMC9429973
Treatment was started correcting the coagulopathy during this period.
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PMC11696659
Likewise, the differential accuracy (Δ accuracy) was calculated for each model set analysed.
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PMC8526701
E Tissue sections from (D) were analyzed by active caspase 3 staining.
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PMC11707577
For every sample, three technical replicates were carried out.
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PMC9429973
Next, ISM-FISH and conventional DC-FISH were performed for bone marrow nucleated cells from 70 patients with MM or monoclonal gammopathy of undetermined significance (MGUS) and the experiments showed a promising qualitative diagnostic ability in detecting t(11;14), t(4;14), and t(14;16) of our ISM-FISH, which was more sensitive than standard DC-FISH, examining 200 interphase cells with its optimal sensitivity of up to 1.0%.
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PMC11742290
CT-26 cell line Higher expression of LGR5Δ5 variant (LGR5 lacking exon 5) was associated with LN metastasesOSCCOSCC tissues (n = 78) LGR5 in primary tumors significantly correlated with LN metastasisGastricGastric cancer tissues (n = 119) LGR5 siRNA enhanced angiogenesis by increasing VEGF expression levelGastricHuman gastric cancer cell line: AGS (silencing genes: LGR5-homo-409, LGR5-homo-1555 and LGR5-homo-2664) Enhanced LGR5 protein expression was not associated with LN metastasis or distant metastasisGastricGastric adenocarcinoma tissues (n = 180) LGR5 expression was positively associated with metastasisLungPrimary NSCLC tissues (n = 122) LGR5 expression was associated with LN metastasisLungNSCLC tissues (n = 22) LGR5 expression significantly correlated with LN metastasisOesophagealESCC tissues (n = 280) LGR5 expression positively correlated to LN metastasisOSCCOSCC tissues (n = 190) LGR5 facilitated metastasis in EOC cells in vitroOvarianOvarian cancer cell line: SKOV3, Hey (LGR5 silenced) and HO8910 (LGR5 over-expressed) A positive association between LGR5 expression, metastasis marker (vasohibin-1) and lymph node metastasisOvarianEOC patient tissues (n = 210) High LGR5 expression correlated with LN metastasisRectalRectal cancer tissues (n = 30) High LGR5 mRNA and protein expression were associated with LN metastasesThyroidThyroid cancer tissues (n = 26)Abbreviation: Epithelial ovarian cancer (EOC), knockdown (KD), overall survival (OS), epithelial-mesenchymal transition (EMT), lymph node (LN), non-small cell lung cancers (NSCLC), oesophageal squamous cell carcinoma (ESCC), colorectal cancer (CRC), and oral squamous cell carcinomas (OSCC), protein kinase A (PKA), cancer susceptibility 15 (CASC15), vascular endothelial growth factor (VEGF), specificity protein 1 (SP1) Summary of the functional roles of LGR5 in cancers LGR5 silencing in U87 cells suppressed cell proliferation and cell cycle and reduced tumor-sphere formation in vitro LGR5 depletion significantly inhibited tumor orthotropic xenograft growth in vivo U87 cell line BALB/C nude mice Human cervical cancer cell lines: SiHa and HeLa cells Female BALB/c-nude mice Depleting LGR5 inhibited proliferation via suppressing WNT signaling in CRC cells Depleting LGR5 induced apoptosis, suppressed β-catenin nuclear translocation and blocked the activity of Wnt/β-catenin signaling LGR5 silencing inhibited cell proliferation, secondary tumor sphere formation and induced cell apoptosis, and G0/G1 phase in vitro LGR5-KD suppressed tumorigenicity of HT29 spheroid cells in vivo Colon cancer cell line: HT-29 BALB/C-nu mice Human colon epithelial adenocarcinoma cell lines: HT-29, DLD-1, Caco-2, and LS123 NOD/SCID mice with Caco-2 cells LGR5 over-expression promotes gastric cancer cell proliferation and sphere cell growth LGR5 enhanced tumorigenesis in vivo by increasing spheroid sizes Human gastric adenocarcinoma cell lines: MGC803 Female BALB/c nude mice Human gastric adenocarcinoma cell lines: MKN45 and MKN28 Female athymic BALB/c nu/nu mice Human gastric cancer cell line: SNU-5 NOD/SCID mice NSCLC tissues (n = 22) Lung cancer cell lines: A549 and H1299 ESCC cell lines: KYSE70, Eca9706, Eca109, and KYSE450 LGR5 promoted proliferation in vitro LGR5 promoted tumorigenesis in vivo Ovarian cancer cell line: SKOV3, Hey (LGR5 silenced) and HO8910 (LGR5 over-expressed) Female BALB/c athymic nude mice with SKOV3 OC cells (n = 6) ESCC cell lines: KYSE70, Eca9706, Eca109, and KYSE450 Thyroid cancer cell lines (TPC-1, KTC-1, Nthy-ori-3–1) (n = 3) Thyroid cancer tissues (n = 26) Abbreviation: Epithelial ovarian cancer (EOC), knockdown (KD), overall survival (OS), epithelial-mesenchymal transition (EMT), lymph node (LN), non-small cell lung cancers (NSCLC), oesophageal squamous cell carcinoma (ESCC), colorectal cancer (CRC), and oral squamous cell carcinomas (OSCC), protein kinase A (PKA), cancer susceptibility 15 (CASC15), vascular endothelial growth factor (VEGF), specificity protein 1 (SP1) High LGR5 expression enhanced tumor proliferation through WNT/β-catenin in lung , gastric , CRC [40, 63, 75, 76, 78–87, 89, 91], hepatocellular carcinoma (HCC) , breast , cervical , endometrial , oesophageal , bone , and brain [71–73] cancers.
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PMC11377827
The hypoxic induction of USP43 was not observed in HIF1β null cells indicating that USP43 expression was HIF inducible (Fig. 1G).
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PMC9429973
Results: SOX11+ MCL showed enrichment in leukemic (LSC) and hematopoietic stem cells (HSC) gene signatures compared to SOX11- MCL primary cases.
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PMC11590870
Many bioactive peptides with antioxidant and anticancer potential have been produced from various plant materials like Moringa oleifera (MO).
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PMC11462673
Our study confirms the co-localization of LDB1 with master TFs in T-ALL cell lines, regulating MYB expression through the formation of transcription complexes, providing new therapeutic approaches for clinical therapy of T-ALL patients.
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PMC8073654
In an assessment of the protective effect of the ethanol extract of Z. cassumunar against LPS-induced neuronal cell loss and the activation of astrocytes in the hippocampus , pretreatment with Z. cassumunar extract (200 mg/kg, i.p.)
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PMC10969097
The Risk of Bias assessment was carried out according to RoB 2 in two clinical trials (NCT00970021 and NCT02486796) (Figure 3A).
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PMC9429973
The gene expression profile evaluated by the Nanostring Lymphoma Subtype Assay revealed two cases of the GCB molecular subtype, while the others were not classified.
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PMC7612475
This results in the accumulation of GFP-RNaseH1 at R-loops, which can be visualized and quantified using high-content fluorescence microscopy as an alternative method for quantifying R-loops (27).
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PMC11746948
To further confirm whether both C66 and C75 residues of GPX4 are palmitoylated, we conducted the acyl-PEG exchange (APE) assays and observed that only a single palmitate was incorporated into GPX4 (Supplementary Fig. 6h).
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PMC3274243
Eight-well Lab-Tek II chamber slides (VWR Intl, UK) were prepared in parallel, with each well receiving 8 × 10 cells well in a 475 μL volume.
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PMC11585254
We provide evidence that a phospho-site cluster located at the extreme distal carboxyl-terminal tail of the receptor is responsible for β-arrestin recruitment and receptor desensitization.
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PMC9429973
Serum assessments of iron (Figure 1), transferrin saturations (TfSAT), and ERFE showed that only animals treated with the T-ASO exhibited significant changes in iron metabolism.
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PMC7840816
The mRNA and protein levels of SOX9 in siRNA-SOX9-transfected BCPAP cells. (
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PMC11727062
Furthermore, research indicates that organometallic complexes centered on the natural product 6-gingerol may serve as innovative chemotherapeutic agents, specifically targeting the mitochondria and the endoplasmic reticulum-Golgi apparatus membrane in A2058 metastatic melanoma cells.
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PMC11703992
At the timepoint of 48 h after PMA induction, DDIT4 expression of PMA-induced group and Blank group was detected by qRT-PCR (Fig. 8A).
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PMC11795610
TRPV4 can be activated by mechanical stimuli, hypoosmolarity, chemical, and physical stimuli, thereby resulting in enhanced Ca influx and regulating many physiological and pathological processes, such as cell growth, signal transduction.
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PMC9429973
Risk-adjusted AEs, representing event rate per 100 patient-years, were calculated for the following: overall and fatal AEs, bleeding AEs (determined by Standardized Medical Dictionary for Regulatory Activities Query [SMQ]), cardiac AEs (by SMQ), major cardiac events (determined by major adverse cardiovascular events [MACE] classification), infections, thromboses, and secondary malignancies.
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PMC11422497
To fully harness the clinical significance of circRNAs in this context, additional research efforts and clinical validation are essential.
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PMC5035325
Two independent observers analyzed five fields in randomly selected tumor areas/animals.
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PMC9429973
Secondary endpoints included duration of response (DOR), complete response (CR) rate, progression-free survival (PFS), overall survival (OS) in cohorts 1 and 2, and safety.
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PMC11589157
124.2 Mb (Hap1), surpassing most gibbon genomes published so far.
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PMC11361748
At baseline, K17 is expressed in skin epithelial appendages (e.g., hair follicles, sebaceous, and sweat glands) but not in the interfollicular epidermis of mouse skin (S2A Fig).
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PMC11473750
c The Pearson correlation coefficient (r) and p value for RNF121 and the MYC signature expression scores for the tissue samples in (a) and (b).
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PMC11295144
After incubation, the cells were rinsed twice and washed multiple times with PBS.
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PMC10213179
Following gastrocnemius muscle resection, the incidence in lung metastasis was reduced to 22% with the ATOP aptamer-treated mice compared with SCR aptamer-treated mice (Figure 8E).
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PMC11680391
One approach has been the “stable school”, where farmer-to-farmer communication catalyzes the implementation of changes .
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PMC9429973
PFS was significantly longer in MRD vs. MRD pts (p=0.003).
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PMC11594588
This leads to excessive and uncontrolled production of free oxygen radicals (ROS).
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PMC11190062
Toll-like receptors (TLRs) play a crucial role in innate immune recognition of microbes and antimicrobial defense.
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PMC11502443
These findings indicate that tirzepatide is a biased agonist towards Gαs signaling and suggests it equally activates the wildtype and E354Q GIP receptor variants.
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PMC11082662
SMPDL3B, sphingomyelin phosphodiesterase acid-like 3B.
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PMC11637276
Remarkably, chemotherapy-resistant breast tumours showed higher mRNA expression levels of MAP3K1, MAPK11, PPP2R1A, and α2 integrin.
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PMC11361748
Remarkably, 6 of these genes, AKR1B10 , ANGPTL4 , OAS1 , HRH2 , KLK1 , and PDPN have known roles in regulating PKCα or other classic PKCs, or at steps downstream from their activation.
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PMC11461874
Flag-tagged proteins are eluted by addition of 150 ng/mL Flag peptide in wash buffer and subjected to immunoblotting.
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PMC11803918
After PBS was washed three times, A375 cells were stained with DCFH-DA and Hoechst 33342 and observed by CLSM.
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PMC10507284
However, the prognostic value and specific functions of TROAP in STS are still undetermined.
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PMC10656496
OS252 was a gift from Richard Gorlick at MD Anderson.
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PMC10878518
The human osteosarcoma cell lines HOS (CRL-1543), MNNG/HOS (CRL-1547), and 143B (CRL-8303) were purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA).
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PMC5308810
In terms of tumor formation, the subcutaneously implanted CXCR4 initiated a much faster tumor growth rate in SCID mice and after 21 days, the average size of tumors was four times larger than the implanted A2780/ADR and CXCR4 tumors (Fig 3C).
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PMC11699042
Among those adult carcinoma cell lines, the authors specifically focused on the estrogen receptor-positive adult breast carcinoma cell line MCF-7 for a cross-laboratory analysis and demonstrated crucial genomic, transcriptomic, and phenotypical diversity.
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PMC6364197
A significant death of Jurkat cells was observed in TCPS (57.67±8.02, 42±4.58%) when compared to CTCPS (78±5.57, 57.33±5.03%) in the presence of DNR for 96 and 168 h (Fig. 5B; *P<0.05 vs. TCPS).
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PMC11759751
B-NHL cells and CD19 CAR T cells were co-cultured at different effector-to-target ratios.
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PMC6889484
It was previously reported that substitution of HIV-1 Vif amino acids DRMR with African green monkey amino acids SE(R/M)Q conferred the ability to induce degradation of A3G-D128K.
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PMC7887261
MLNR variants and dysregulation have been implicated in lung occult small cell carcinoma, bile duct cancer, and head and neck cancer.
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PMC10329237
After phosphorylation, Smad2 and Smad3 are combined with Smad 4, then the Smad2/3-Smad4 complex translocates to the nucleus to regulate gene expression by interacting with DNA binding transcription factors.
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PMC11190538
Fermented milk has significant radical scavenging properties, indicating its potential as a natural antioxidant supplement for enhancing human health.
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PMC9429973
A common denominator of aging is the development of somatic mutations within the hematopoietic stem cell compartment.
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PMC7685376
MCM proteins were up-regulated in HCC cell lines and tissues. (
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PMC11531735
JIMT-1 cells are characterized by amplified HER-2 oncogene expression without identifiable mutations in the coding sequence.20 Female athymic nude mice, 15 mice in each group, were injected with JIMT-1 cells and were subsequently treated with PBS (Control), or injection of Enhertu (an FDA-approved antibody-drug conjugate consisting of trastuzumab and deruxtecan), at 3 mg/kg or 10 mg/kg or ER121 at 10 mg/kg, or Herceptin at 10 mg/kg on alternate days over a 2-week period.
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PMC11786767
Lipid-containing structures in the cytoplasm, nuclei (e.g., the NE), and nucleoli were clearly labeled by biotin-DHPE (Fig. 1A), confirming the feasibility of deploying biotin-DHPE in TT-ExM to reveal cellular lipid structures.
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PMC10899471
This work demonstrated for the first time that upregulation of miR-939-3p promoted sarcoma cell proliferation in vitro and enhanced tumor growth in vivo.
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PMC11519583
b Expression of Ror2 in MPs isolated (sorted) from the skeletal muscles of either control or Ror2 cKO mice was monitored using quantitative RT-PCR analysis (n = 3).
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PMC10882807
Transwell assays were used to detect cell migration and invasion of BEL-7404 cells transfected with siNC, si1and si2 (Magnification, 20X; Scale bars, 200 μm). (
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PMC8345486
It enhanced cisplatin proapoptotic effects in cancer cells, and did not induce cross-resistance to standard anticancer drugs.
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PMC11741906
Interestingly, the most meaningful finding was that these miRNAs were involved in major biological processes and functional categories related to the cellular response to cytotoxic therapy and cell death/survival signaling, such as stress activated signaling, apoptosis regulation, DNA damage response signaling, kinase binding, and purine ribonucleotide binding.
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PMC8956657
As expected, the Arg33 bound at the Gly150, Thr155, and Asp192 pocket.
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PMC11332076
A pull-down assay revealed that neither F-iIR nor F-iIGF1R bound to F-iIR-GST or F-IGF1R-GST (Fig. 5).
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PMC11792766
No. X100), and DMSO (Sigma Aldrich, Cat.
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PMC9429973
Further, we investigated the impact of emerging TKI-resistance on cell adhesion and migration.
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PMC11635087
F, G) Electron microscopy images of incorporated chloroplasts in a CHO-K1 cell at 2 days after the co-cultivation.
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PMC11320084
These results indicated that TNNT1 knockdown inhibited EMT of LC cells.
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PMC5330095
Preliminary screening of cannabidiol (CBD) revealed that CBD is active against HCV but not against HBV in vitro.
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PMC11599565
Lane 1, SKOV3 cells cultured in 2D DMEM; lane 2, SKOV3 cells in 2D DMEM; lane 3, SKOV3 cells in 2D Neuropan neuronal induction medium.
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PMC11206502
Cytotoxicity was evaluated using the alamar blue assay, and the degree of autophagy was determined microscopically.
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PMC9429973
Enrollment in Cohort 1 is ongoing with 5 patients included so far.
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PMC6337547
Liver cells are protected by the anti-inflammatory and anti-oxidant properties of salvianolic acid B .
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PMC8193813
To determine the comparative accuracy of the measurements, the UAS-based emission factor was compared to the stack continuous emission monitoring systems (CEMSs).
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PMC9429973
Sanger sequencing was used to confirm the identified mutation.
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PMC10698968
B Representative images of morphological aspects of MFS cells after spontaneous immortalization.
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PMC11306331
We co-expressed FUS-CHOP with the rtTA transcription factor and constitutively expressed OptoMBP light-induced dissociation system (MBP-SspB-iRFP) (Fig. 5A).
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PMC9429973
Notably, bcor mutation repressed autophagic flux in cultured cells, as corroborated by decreased expression of autophagy marker genes (e.g., ATG7, ATG10) and reduced numbers of autophagosomes or autolysosomes, which were accompanied by upregulation of HDAC6, downregulation of FoxO1 and ac-FOXO1.
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