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PMC11265931
The nanoparticle tracking analysis (NTA) of garlic SEV reveals a size distribution ranging from 50 to 160 nm (Figure 1C).
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PMC11770199
GSDME cleavage was analyzed by immunoblotting 20 h after transfection.
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PMC10936243
Phase 1 involved a survey consisting of 14 questions which were divided into three sections (demographic details, basic management and barriers experienced by practices) and emailed to 143 Malaysian veterinarians.
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PMC8140214
However, after 72 hr treatment, CAT activity significantly decreased in both 30 and 50 mM D-glucose-treated cells.
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PMC9429973
Summary/Conclusion: In conclusion, we identified MYCN as a recurrent aberrantly overexpressed gene in PTCL, and characterized the oncogenic mechanisms underlying MYCN overexpression, which led to the identification of novel targeted treatments for PTCL.
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PMC11087301
EMT initiation participates alterations in gene expression and activation of signals .
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PMC9429973
PEG-rhG-CSF(xinruibai) was used in the hematopoietic recovery and given in the dose of 100μg/kg on day +1and day +8.
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PMC11200978
Third, as with any in vitro assessment, translation to clinical application is unlikely to be linear.
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PMC9261184
It was noted by several engineers onboard that BOG generation is very low with current insulated LNG storage techniques and the ship can operate much more efficiently than with older systems.
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PMC11541409
In GIST T1 (IC50 10.7 nM) and GIST 882 (IC50 17.8 nM) cells, treatment with imatinib for 2 years resulted in T1R (IC50 46 µM) and 882R (IC50 55 µM) cells without secondary mutations, which show elevated glycolysis, increased lactate production (ECAR), and a lower oxygen consumption rate (OCR) .
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PMC10812665
Utilizing the Sykam S433 amino acid analyzer (Sykam, Fürstenfeldbruck, Germany), the separation of amino acids was carried out by HPLC (lithium-based anion exchange column: 7 µm diameter, 10% cross-links, cat# 5125022) and post-column derivatization with ninhydrin.
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PMC11502327
Dihydroartemisinin is a recognized STAT3 inhibitor and PTGS1 inhibitor (239, 240).
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PMC11544771
For this, we first evaluated the morphology of A549 and A427 cells treated with CPX (0–2.5 μM) in combination with PRE (0–5 nM) for 5 days.
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PMC10170482
Then, cells were labeled with the LIVE/DEAD Viability/Cytotoxicity Kit.
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PMC7723249
To get around the problem of BSL-4 laboratory requirement, Hazara virus (HAZV), a tick-borne virus belonging to the same serogroup as CCHFV, has been proposed as a surrogate to CCHFV for in vitro and in vivo studies [15–17].
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PMC8427838
Expression of TMIGD1 in RKO cells is shown (Fig. 4B).
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PMC11095939
Huang and colleagues reported that the absence of the primary nuclear bile acid receptor FXR (also known as Nr1h4) strongly inhibited liver growth in the early stages of regeneration (Huang et al., 2006).
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PMC11755624
Frequently, the stimulation of immune responses is also associated with the enhancement of keratinocyte proliferation.
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PMC8711270
Retroviral vectors are enveloped, single-stranded RNA viruses.
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PMC9429973
Results: For this meta-analysis, data were combined from five cohorts: four published cohorts (STIM2 cohort [Nicolini et al.], n=175; ISAV cohort [Diral et al.], n=107; Bernardi et al., n=111; Colafigli et al., n=50) and 1 unpublished cohort (Dutch cohort; n=40).
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PMC11541241
When chemical fungicides and biopesticides are applied, the off‐target effects should be noted.
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PMC9428827
No-alpha mutein effect on survival of tumor-bearing mice was also tested.
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PMC8193813
Flue gas analysis for O2 and CO2 is performed in accordance with US EPA Method 3A (2017) using an infrared analyzer to allow for calculation of the flue gas dry molecular weight.
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PMC11271278
All DNA FISH samples were imaged using a Nikon Eclipse Ti-2 microscope coupled with a CSU-W1 spinning disk confocal scanner unit (Yokogawa).
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PMC10810426
Lentiviruse PICs enter the nucleus of quiescent cells through interaction of viral capsid/nucleocapsid proteins with the nuclear pore complex (NPC) .
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PMC11703992
Giant cell arteritis (GCA) is a prevalent artery and is strongly correlated with age.
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PMC7723249
Although HAZV and CCHFV belong to the same serogroup, they don’t have the same pattern of infection in fully polarized cells, suggesting the use of different receptors, at least in Caco-2 cells.
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PMC10656496
Treatment with panobinostat and then trametinib successfully eliminates both cell lines at 24 days.
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PMC11476222
GD1a elutes before GD1b on the ZIC-HILIC column.
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PMC9429973
At the time of data collection, one patient had deceased.
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PMC11714165
Luminescence intensity‐matched mice were randomly assigned to five groups, with 5 mice in each group.
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PMC9429973
The addition of GO to FLAI did not increase CR rate.
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PMC8494202
For example, Xiong et al. determined that abnormal expression of CKAP2L was highly correlated with poor prognosis of lung cancer and may be regulated by the MAPK signaling pathway .
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PMC9429973
Our cohort had a similar frequency of del(6q) than published series, with particular involvement of 6q23 and 6q25 breakpoints.
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PMC10847511
Similarly, among the compounds studied in the PRISM, those relevant to the field of oncology were retained.
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PMC11643361
Silver complexes show significant potency, particularly in resistant cancer cell lines, suggesting that they could be valuable in targeting drug-resistant cancers.
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PMC11681005
We chose two cell lines for analysis: the RT4 cells with the TACC3‐FGFR3 fusion as a less malignant luminal‐like BLCA (Luminal, L) and the 5637 cells with homozygous TP53 mutation and amplified ERBB2 as an aggressive and malignant human muscle‐invasive BLCA (Basal, B) (Figures 1B,C and 2, and Dataset S1).
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PMC11543885
Digest the biotinylated proteins by incubation with trypsin for 16 h at 37°C (1 μg trypsin / 20 μL streptavidin beads).
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PMC10213179
Potentially, the higher affinity of the ATOP aptamer compared with these other EphA2 aptamers for EphA2 may be due to how we identified ATOP using data from both a protein-based SELEX and cell-internalization SELEX.
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PMC11225860
The 100µM group had a lower cell viability of 72% and the 200µM Aurkin A group had a drastic decline to a viability of 14%.
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PMC11755624
SH3PXD2A-AS1 is significantly upregulated in psoriasis skin tissue, and it was found to stimulate keratinocyte proliferation.
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PMC4369959
Ginger is thought to act directly on the gastrointestinal system to reduce nausea.
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PMC11694066
Cells were collected in cold PBS, counted, and adjusted to 50,000 cells per 50 μL PBS on ice.
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PMC9275501
The results showed that PTX-BCL nanoparticles exhibited good antitumor activity in a wide range of drug concentration and had obvious synergistic effect.
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PMC11674146
These two cells were hence applied in subsequent assays.
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PMC9429973
Aims: Here, we describe a comprehensive evaluation of the effect of avapritinib on bone marrow (BM) pathology in patients treated in these studies.
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PMC11422497
However, for patients with advanced or metastatic disease, especially those harboring c-kit and/or PDGFRα mutations, additional therapeutic modalities are often necessary.
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PMC11423992
T-cell redirection was visualized through fluorescence imaging using a high-content analysis system (PerkinElmer).
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PMC11599565
Isolation of cells was identical to that of the colon-derived neuronal cells.
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PMC4443654
We also observe consistent increases in GC content at TAD boundaries, at a scale that is difficult to reconcile with the presence of smaller-scale features such as repeat elements or CpG islands (Additional file 1: Figure S12).
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PMC11467964
We selected PSAT1 for additional functional studies, as it exhibited abnormally high expression in all three STS cell lines.
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PMC10898159
SH3BP2 promotes the expression of mutant KIT by up-regulation of the expression of MITF and ETV1.
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PMC9966931
The production of hybrid molecules was confirmed by means of GC-MS.
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PMC11144200
n = 3, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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PMC10818573
To reduce the assay cost and optimize the procedure, we built our own amplification system containing nfo.
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PMC11055323
These results suggest that SS18-SSX acquire the ability to exclude repressors through its oncogenic translocation.
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PMC9164404
Even to cisplatin-resistant cells, like A2780DDP and BEL-7404DDP, Abplatin still had the killing capability.
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PMC11188874
Despite a limited understanding of the molecular mechanisms of pathway targets, the regulation of UBL modifications is an attractive, and increasingly tractable, approach to targeting aberrant signaling pathways in multiple cancers and other diseases (51).
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PMC9219615
The next day, cells were exposed to Tpz-1 concentrations ranging from 0.01 to 10 μM, 1% v/v DMSO (vehicle control), 1 mM H2O2 (positive control), or left untreated (UNT) for 24–72 h. Four independent measurements were used for the samples, except for the vehicle control in which eight DMSO-treated independent measurements were used to ensure the average total cell count was representative for each experiment series.
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PMC9577200
Regarding the GO-CS composite, all treatments showed increases in turbidity with increasing time.
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PMC11472639
Represents the same gating strategy as ‘B)’ but from a post-exercise sample.
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PMC11753435
Next, the target and peptide encoders were trained on batches of n pairs of targets and peptides that are known to interact from the datasets described above.
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PMC9844987
Although frQTLs were associated with promoters across the wide spectrum of promoter variabilities (Figure 5C), they showed a large difference in their relative effect on the overall promoter activity (maximal relative change in expression between reference and variant alleles; Figure 5F).
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PMC11361748
We next explored whether one can uncover a transcriptional signature consistent with TAR, as seen in mice, in human skin disorders with a known neutrophil involvement (see below).
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PMC9268620
Uncontrolled, prolonged elevations of cytosolic Ca can result in cell death (apoptosis) because calcium damages cellular proteins and membranes by activating Ca-dependent degradative enzymes, such as proteases and endonucleases , and by promoting free radical production via the activation of lipases .
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PMC6450504
bPEI-modified liposomes (PEIPOS) showed enhanced association with three different cell lines by up to 75 times compared to plain or PEGylated liposomes and were without carrier toxicity.
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PMC9503669
Several other assay systems have been reported for the identification of Nef inhibitors.
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PMC11462929
In addition, Hi‐C analysis of GM12878, a MYC‐positive Epstein–Barr virus (EBV)‐transformed human B‐lymphoblastoid cell line, indicated that BENC‐CNA but not N‐ME was topologically proximate to MYC (Figure 1A).
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PMC11055323
a Representative image of immunofluorescence for H3K27ac in the BJ fibroblasts with lentiviral expression of SS18-EGFP or SS18-SSX1-EGFP.
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PMC11001582
To further validate these layer-specific neuronal impairments, we performed high-density in vivo Neuropixels recordings in a subset of the same mice and in an additional cohort, including C9orf72 eGFP knock-in mice, to assess single-unit and population neuronal activity.
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PMC4270159
Data to be collected:Images of probed membranes (images of full films with molecular weight ladders).Scanned image of Ponceau-stained membranes after protein transfer.
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PMC11361748
PKCα, the direct target of TPA, fulfills key roles in skin including the regulation of inflammatory responses and of desmosome cell-cell adhesion [40–42].
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PMC9429973
Half (35 studies) explicitly described the rationale for combination chelation therapy: DFP+DFO, 24 studies, 33.8%; DFX+DFO, 6 studies, 8.5%; and DFP+DFX, 5 studies, 7.0%.
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PMC11469524
We decided to fix the inhibitor coefficients to values learned from the BL-2 model so that changes in response are now reflected in the other coefficient path(s).
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PMC10788478
EGFR mutation testing was achieved using the SmartAmp2 kit (DNAFORM) as previously described, and mutations were confirmed by direct sequencing using the ABI PRISM 3100 DNA Analyzer (Applied Biosystems).
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PMC11012313
However, it would be interesting to determine if LMP2A also promotes mTOR-dependent increases in ATP under hypoxic or anoxic conditions.
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PMC10443665
After incubation for 48 h isolated cells were washed twice with PBS followed by total cellular RNA extracted from a minimum of 1 × 10 cells using the Trizol method according to the manufacturer's instruction.
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PMC10850553
The images of immunofluorescent staining of IA lesions for C5a/C5a des-arg which is the derivative of C5a (green), tPA (red), and merged images with nuclear staining by DAPI (blue) are shown.
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PMC10823017
The primary c-Myc antibody was made in 1.5% Bovine Serum Albumin (BSA) in DPBS (1:50 dilution), and the slides were incubated overnight.
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PMC11790971
a Permutation feature importance of the top 30 most important features for cell line classification in passage 2.
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PMC8143558
Gram-negative bacteria have an external membrane that is absent in Gram-positive bacteria.
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PMC11224020
Of note, this pathway is the only pathway described so far as being implicated in the homeostatic migration of skin DCs.
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PMC10988555
Among them, ruthenium complexes have drawn great attention due to their broad spectrum of activity, low toxicity, and lower drug resistance than cisplatin.
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PMC11209164
After 24 h post-infection, fluorescence images were captured using the EVOS Live Cell Imaging System (Thermo Fisher, San Francisco, CA, USA) the supernatant was assessed for viral titer by standard plaque assay.
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PMC11721587
Activated Fu phosphorylates Ci at multiple sites, priming CK1-mediated phosphorylation at adjacent sites, which promotes Ci activation by attenuating Sufu binding (29–31).
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PMC6222726
This compound showed an interesting activity against Trypanosoma cruzi, , but with a low parasite selectivity .
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PMC9429973
To-date, anti-CD44 is the most effective release agent in our model, but it still failed to release all AML cells.
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PMC11093197
In triple‐negative breast cancers (TNBCs), the RB1 loss signature was found to be associated with high β‐catenin signaling.
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PMC11257203
After 24 h, bone marrow cells were obtained from mice femurs.
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PMC11585254
HEK293 cells expressing WT CXCR5 or phospho-site cluster variants and the pGloSensor, which luminesces in proportion to cAMP levels, were pretreated with vehicle or increasing concentrations of CXCL13 (10, 30, and 100 nM) for 30 minutes at 37°C.
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PMC11716858
Amyloid‐β (Aβ) deposition, a major hallmark of the disease activates microglia leading to neuro‐inflammation and neuro‐degeneration induced by activation of COX‐2 via NFkB p50 in glioblastoma cells.
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PMC11743975
However, in the COS-7 cells co-transfected with Tom20-CIBN-GFP and mCherry-CRY2clust, we detected upon blue light illumination the robust formation of mCherry-CRY2 protein clusters in the cytosol and the concomitant formation of mitochondrial aggregation after 60 min of light activation (Figure 2B, Supplementary Video S2).
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PMC11742431
Protein purification results for RL (control group), RVL (experimental group), and R14L (experimental group). (
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PMC10674574
Moreover, for regulatory validation purposes (e.g., BCS classification), an additional high-permeability internal standard (HP-IS) and low-permeability internal standard (LP-IS) should be established.
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PMC9429973
And another two patients with FL was suspected progressive disease during observation (no lenalidomide maintenance).
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PMC9429973
Intermediate group was predominant (48,5%), 28 patients (32%) had normal karyotype.15 patients (17%) had unfavourable cytogenetics including 9 patients with complex karytype and 3 patients with del7q.
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PMC11539788
All the cell lines assayed in the present study were identified by STR profiling.
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PMC9429973
25 pts (40,98%) were transplant eligible (TPH).
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PMC11365427
Binding energy analysis and visualization were performed using PyMOL and Discovery Studio software.
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PMC10502403
T2 cells (HLA-A2, TAP-deficient, Epstein–Barr virus-transformed lymphoblastoid cell line), SW982 cells (NY-ESO-1/HLA-A2 synovial sarcoma cell line), Fuji cells (NY-ESO-1/HLA-A2 synovial sarcoma cell line), and NW-MEL-38 cells (HLA-A2, NY-ESO-1 melanoma cell line) were cultured in RPMI-1640 medium supplemented with 25 mM HEPES, 10% fetal calf serum (FCS), 2 mM glutamine, 100 U/mL penicillin, and 100 μg/mL streptomycin.
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