OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11291490	The cells (for qRT-PCR) and supernatant (for ELISA) were collected at 48 h post-stimulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "(", "for", "qRT-PCR", ...
PMC9841531	The reference ABCB1 inhibitor 34 and the reference ABCG2 inhibitor 36 were procured from Sigma-Aldrich (St. Louis, MO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reference", ...
PMC7759933	Another important group of phase II enzymes is N-acetyltransferases (NAT) that catalyse the activation of aromatic and heterocyclic amines via O-acetylation, while N-acetylation of the parent amines is considered a detoxification step .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11218145	In fact, by 7 weeks from MPM cell inoculation, 10/10 mice treated with vehicle and 5/10 mice treated with TB were dead.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11457557	It is worth noting that a decline in kidney function is measured by the decline in the eGFR, while glomerular filtration barrier dysfunction, is measured by albuminuria, can occur independently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The median age of patients was 37 years (range, 15-84).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "The", "median", "age", "of"...
PMC11401350	Conversely, CD4-LV mediated the exclusive generation of CD4CAR T cells, which were equally active in eliminating tumor cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "CD4-LV", ...
PMC9429973	Of the 37 patients who started ponatinib due to intolerance to previous TKIs, 59% (15 CML, 7 Ph+ALL) achieved MMR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11695623	We used R software to analyze the differential genes between DCUN1D5 high expression group and low expression group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "R", "software", "to", ...
PMC11787381	In Aβ1-42-injected mice, daily bambuterol (300 µg/kg/d) increased synaptophysin (p < 0.05, versus Aβ1-42- injected mice treated with the vehicle) (Fig. 8A) and PSD95 (p < 0.10) protein levels (Fig. 8B) indicating a protective effect on synapses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In our pilot study we observed similar response rate though it was not a randomized data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "pilot", "study", "we", "observed", ...
PMC11013014	HRMS (+ESI) m/z: [M + H] calculated for C23H19Cl2N6O3: 497.0890, found: 497.0887.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HRMS", "(", "+", ...
PMC10362265	Orange and blue colors mark the left and right interfaces, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Orange", "and", "blue", "colors", "mark", "the", "left", "and", "right", "...
PMC11675244	However, with such fundamental implications in basic cellular processes, these signaling networks are often prone to malfunctioning into human malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC11507371	Different studies showed that RNS can act either as an activator of NF-κB signalling via degradation of IκBα or repress NF-κB signalling through nitration on tyrosine residues of p65, leading to its destabilisation, nuclear export, and inactivation of NF-κB activity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222635	It was obvious that molecular weight played an important role in anti-tumor activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "obvious", "that", "molecular", "weight", "played", "an", ...
PMC9429973	We aimed to dissect expression of crucial regulatory and signalling factors in thymus tissue samples and interpret them in the context of known healthy thymus characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4277423	After successfully disrupting CCR5 gene in human T cell lines, we have made several attempts to disrupt CCR5 gene in human primary T cells from multiple donors with lentiviral vectors expressing Cas9 and sgRNA CR2, including a single lentiviral transfer construct that co-expresses Cas9 and sgRNA CR2 along with GFP marker protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10213179	Conducting the two SELEX strategies independently of each other and then bioinformatically comparing them using the clustering algorithm has two distinct advantages over integrated SELEX strategies such as Toggle SELEX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9684669	Immunoblot analysis was performed with indicated antibodies and the chemiluminescence signal was visualized with Luminata Forte Western HRP substrate (EMD Millipore) in a BioSpectrum system (UVP, LLC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699042	e Relative variation in cell viability for each EwS cell line measured as the mean area under the curve (AUC) m12 vs. m0 for the extended drug library (20 compounds).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	A limitation to the development of CAR T-cell therapies is the requirement for a distinct tissue-restricted target antigen on the tumor cell surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC11591030	Compared to the CON and AOP groups, the LPS group significantly upregulated the gene expression of the NF-κB signaling pathway-related factors and decreased the expression of the IkBα gene (p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	For RT-qPCR, total RNA was extracted from the cell pellets using the PureLink RNA mini kit (Thermo Fisher) and reverse-transcribed using an iScript cDNA synthesis kit (Bio-Rad, Hercules, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11300085	Chemerin induces metastasis of gastric cancer cells via CMKLR1 and CPR1/TIMPs pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemerin", "induces", "metastasis", "of", "gastric", "cancer", "cells", "via", "...
PMC9429973	In the remaining 116 patient pairs remdesvir significantly reduced the mortality: 36 out of 106 treated patients died, in comparison to 54 untreated (p=0.0207, McNemar’s test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4277423	Although these studies showed that CCR5 gene disruption can be generated in 293 and K562 cells and iPSCs and modified iPSCs, when differentiated into monocytes/macrophages, were resistant to HIV-1 challenge, the efficiency and the specificity of individual sgRNAs that target different CCR5 sequence segments in human CD4 T cells, the major cell targets for HIV-1, remain to be carefully evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11297139	Lastly, we studied the concentration-related formation of nuclear ARID1A condensates by tracking the nucleoplasmic concentrations at which ARID1A proteins started to form condensate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11742290	LGR5 protein expression was decreased in glioblastoma cancer cells (U87) when treated with increasing concentrations of TCS in vitro .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LGR5", "protei...
PMC11075223	The following keywords were retrieved from these websites, including “Cimicifugae Rhizoma”, “Cimicifuga”, “C. heracleifolia”, “C. dahurica”, “C. foetida”, “cohosh”, “ethnopharmacological use”, “triterpenoid saponins”, “phenylpropanoids”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11622247	With the brighter light-harvesting probe JK2 it was possible to observe a population of Jurkat cells that exhibited fluorescence levels exceeding those observed in mock microporation (Fig. 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7215832	We investigated the mechanism and potential of RX-3117 as a demethylating agent in several in vitro models. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "investigated", "the", "mechanism", ...
PMC11434983	Briefly, 50 μL (~74 kBq) of the isolated complex was added to a centrifuge tube containing 4 mL of a 1-octanol/PBS (0.1 M, pH 7.4) (1:1) mixture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9118379	SpecOMS: minimum peptide length = 7, maximum peptide length = 50, threshold = 6, max masses count = 100, minimum peptide charge = 1, maximum peptide charge = 7, number of decimals = 2, decimal value = 4, decoy base = false.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257203	P < 0.001 Indicates significant differences compared to the control group; P < 0.05 and P < 0.01 between the designated groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", ...
PMC11759543	The combination of vorinostat and other drugs may enhance the anti-cancer effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "of", "vorinostat", "and", "other", "drugs", "may", "enhanc...
PMC9429973	Despite a high rate of response to induction chemotherapy, only 30–40% of adult patients with ALL will achieve long-term remission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "a...
PMC11092382	The underlying mechanism may be attributed to the modulation of TLR4 expression and NF-κB and MAPK activation (Lu et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11300639	The siRNAs were obtained from RiboBio (Guangzhou, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "siRNAs", "were", "obtained", "from", "RiboBio", "(", "Guangzhou", ",", "China"...
PMC11699042	g Combined transcriptomic PCA of our A-673 and HeLa datasets and that of Liu et al. (HeLa_Liu) (N = 13,569 transcripts).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10874773	Ye Jin: Data curation, Formal analysis, Visualization, Writing – original draft.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ye", "Jin", ":", "Data", "curation", ",", "Formal", "...
PMC11521786	This work presents a new vaccine candidate that comprises the extracellular domain (ECD) of HER3 (HER3-ECD) as an antigen vaccine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10443665	Tragacanthin-induced chemosensitivity of CCRF-CEM and CCRF-CEM/R cells to MTX could be related to its effect on the down-regulation of MDR1 mRNA expression.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11676674	The relaxing effects of C. monspeliensis aerial parts on isolated vascular and intestinal smooth muscle in vitro also have been established .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relaxing", ...
PMC9429973	Karpas-299 cells genetically-manipulated to express RIPK3 were used to demonstrate involvement of necroptosis in drug-induced cell death (Cytotox NIR) in vitro.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9587298	The results obtained in this work show for the first time that phenolic compounds present in elderberry have antiglycation activity by trapping MGO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10606998	Figure 5e,f show photographs of plates with stained cell colonies obtained in one of the experiments, illustrating the effect of sensitization by nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8526701	A Indicated cell lines were transfected with siRNA against BRD9 for 24 h, BRD9 protein level was analyzed by western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Indicat...
PMC11514418	The results of a meta-analysis also showed that APS-based TCM decoction can increase the effectiveness and reduce the toxicity of platinum-based chemotherapy for advanced non-small cell lung cancer in randomized clinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705484	5637 cells were transfected with pGL3‐luciferase reporter constructs encoding empty vector (NC), wild type TRMT61A promoter with both of the two NF‐κB binding sites (wt‐TRMT61A), wild type TRMT61A promoter with NF‐κB binding site 1 only (wt‐TRMT61A‐site 1) or site 2 only (wt‐TRMT61A‐site 2), or mutant TRMT61A promoter with mutations at the NF‐κB binding site 1 (mut‐TRMT61A‐site 1) or site 2 (mut‐TRMT61A‐site 2) for 48 h. Firefly luciferase activity was measured and normalized to Renilla luciferase activity. (	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10976516	And, even so, only induction of a powerful anti-tumor response through OV’s immunotherapeutic effect can guarantee lasting remission of most if not all metastatic lesions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10778532	We asked whether if VHL-C162F mutation can impact healing abilities by a scratch test of wound healing assay at high confluence (Figure 1I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10728200	We then constructed the point mutation plasmids by mutating the lysine (Lys) to the arginine (Arg), which cannot be modified by ubiquitination, and performed CO-IP experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	N-GSDMDcleaved PARPp-MLKLAgeHuman non-exposed areaPearson’s rN-GSDMD10.6720.5540.557cleaved PARP0.67210.5470.476p-MLKL0.5540.54710.677Age0.5570.4760.6771P (one-tailed)N-GSDMD–0.0080.0310.03cleaved PARP0.008–0.0330.059p-MLKL0.0310.033–0.008Age0.030.0590.008–Human sun-exposed areaPearson’s rN-GSDMD10.716−0.0480.595cleaved PARP0.7161−0.1320.717p-MLKL−0.048−0.1321−0.1Age0.5950.717-0.11P (one-tailed)N-GSDMD–0.0040.4410.021cleaved PARP0.004–0.3420.004p-MLKL0.4410.342–0.378Age0.0210.0040.378– Linear regression analysis of N-GSDMD, cleaved PARP, p-MLKL and age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	Once flask medium reached an optical density at 600 nm (OD600) of 0.50 to 0.75, protein production was induced with 0.6 mM of isopropyl β-d-1-thiogalactopyranoside (IPTG, Millipore Sigma OmniPur–Calbiochem, Catalog # 5820, Burlington, MA, USA) and allowed to further incubate at 37 °C for 6 to 10 h. After incubation, cells were harvested at 6000× g for 10 min, and the pellet was resuspended in Resuspension Buffer (6 M Guanidine hydrochloride, 200 mM NaCl, 10 mM Benzamidine, and 50 mM Tris, pH 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The median age was 41 (range 17-57) and sex ratio was 1.5 (22M/12F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "was", ...
PMC11720107	Foetal bovine serum (FBS), a Universal RNA Purification Kit (E3598-02), and quantitative PCR (qPCR) master mix (Fast Probe qPCR Master Mix) were obtained from EURx (Gdańsk, Poland).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755519	EVs can help cancer cells excrete cytotoxic drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EVs", "can", "help", "cancer", "cells", "excrete", "cytotoxic", "drugs", "." ] } ]
PMC3203927	In Table 2 we list 16 cytokines selected by stepwise discriminant analysis with a cut off p-value of 0.01.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "Table", "2", "we", "l...
PMC8524093	Humoral response is also very important to virus depuration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Humoral", "response", "is", "also", "very", "important", "to", "virus", "depuration", "." ] } ]
PMC11618052	The author reported no potential conflicts of interest(s).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "author", "reported", "no", "potential", "conflicts", "of", "interest(s", ")", "." ] } ]
PMC11300639	Moreover, we noticed a similar effect on changes in VEGFA and p-S6K1 (T389) levels: knockdown of RNF26 in ccRCC cells altered the sensitivity to palbociclib and everolimus (Supplementary Fig. 6e–h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	Quantitative RT-PCR showed no significant differences in mRNA expression for MCL-1 or cyclin D3 at these time points (Fig. S5), supporting the conclusion that mTOR inhibition decreases MCL-1 protein in the OCI-LY1 and OCI-LY7 cell lines at the translational level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10094992	NR6 treatment prevented neutrophil recruitment by exerting its effect on tumour cells, as neutrophils did not express ALDH1A3 and were insensitive to its inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	The primary endpoint is overall response rates (ORR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "endpoint", "is", "overall", "response", "rates", "(", "ORR", ")", "." ...
PMC7185206	Clinical studies are warranted to validate these findings in patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "studies", "are", "warranted", "to", "validate", "these", "findings", "in", "patients...
PMC11612626	A hallmark of cancer is the ability to evade immunosurveillance by disrupting the antigen presentation machinery and downregulating MHC-I antigen presentation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "hallmark", "...
PMC11680049	Cytotoxicity of the extracts was evaluated after 72 h of exposure at concentrations ranging from 7.5 to 1000 µg/mL. At the end of the experiment, cells were incubated for 3 h in the presence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT, DiaM, Moscow, Russia) at a concentration of 0.5 mg/mL. The resulting formazan crystals were dissolved in 100% DMSO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Both genes were highly expressed across the entire cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "genes", "were", "highly", "expressed", "across", "the", "entire", "cohort", "." ] } ]
PMC8316344	Indeed, knocking TFRC out and overexpressing βTrCP both reduced cell proliferation in SK-Hep1 cells (Fig. 7E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "knocking", ...
PMC11637276	While 50 μM ERK1/2 inhibition reduced ECM internalisation, inhibition of MEK1/2, an upstream activator of ERK1/2, did not reduce ECM uptake at effective inhibitory concentrations starting from 10 μM (S5B Fig).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697189	The asterisks represented the statistical p value (: P < 0.05; : P < 0.01; **: P < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	RNeasy mini kit (Qiagen #74106) was used to extract total RNA from cells 72 h post siRNA transfection or protein overproduction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11661024	Lactobacillus fermentum species are the dominant constituent of the gastrointestinal tract microbiome and enhance vaginal tract health by reducing infection risks .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lactobacillus", "fermen...
PMC11629461	Photodynamic action (450 nm, 85 mW/cm, 1.5 min) with the in‐frame miniSOG of construct miniSOG‐NOX5 was found to similarly elicit persistent Ca oscillations, which were inhibited completely by pretreatment with DPI 10 μM, and blocked completely by O2 quencher Trolox‐C (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10914904	This review aims to provide insights into vtRNA biology, interactions with innate immune system proteins, roles in antiviral responses and immunological diseases, and involvement in other cellular processes, including potential contributions to pathways such as NF-kB activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680049	It is possible that the active biosynthesis and accumulation of terpenoids and polyphenols in the vascular and associated tissues also represent a certain adaptive component that helps the plant organism overcome stress factors that arise with increased height .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: For the early post-cycle 4 timepoint, there was low agreement between NGS (sensitivity threshold 10) and MS; there was 46% agreement (Cohen’s kappa -0.18) between NGS and EXENT and 54% agreement (Cohen’s kappa -0.15) between NGS and LC-MS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8873393	Cyt, cytoplasm; Chr, chromatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cyt", ",", "cytoplasm", ";", "Chr", ",", "chromatin", "." ] } ]
PMC8557138	Bayat et al. engineered a HUVEC vascularized 3D tumor model of glioblastoma to test the efficacy of the drug atorvastatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bayat", "et", "al.", "...
PMC9429973	This was also the case in GVHD target organs, including liver and lungs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "also", "the", "case", "in", "GVHD", "target", ...
PMC11774747	Factors such as the persistence of CAR-VSTs in the blood, their expansion in response to viral reactivation, and their residency at tumor sites are critical to achieve sustained antitumor activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9509578	NoNanoparticles (NPs)Chemotherapeutic drugsExperimental modelMechanism of actionRefsNanomicelles1TAT-TPGS-PEG-b-P(ALA) nanomicellesDoxorubicinHuman breast cancer (MCF-7 and MCF-7/ADR cells)Inhibition of P-gp efflux pump and intracellular drug retention and enhanced cytotoxicity2Folic acid conjugated P(OEGMA300)-st-P(HEMA-g-LA) nanomicellesDoxorubicinHuman cervical cancer (HeLa cells)Enhanced intracellular drug accumulation and tumor microenvironment-triggered drug release and cytotoxicity3Polycarbonate based NO nanomicellesDoxorubicinHuman breast cancer (MCF-7/DOX cells)Nitric oxide-mediated P-gp inhibition, intracellular drug accumulation and cytotoxicity4Nitrate functionalized TPGS nanomicellesDoxorubicin, adjudin and nitric oxideHuman breast cancer (MCF-7/ADR cells), murine mammary carcinoma (4T1 cells) and BALB/c miceControlled drug release, enhanced cytotoxicity, P-gp inhibition, reduction in tumor growth and reversal of MDR5Poly (β-amino ester) polymer-based nanomicellsDoxorubicinHuman breast cancer (MCF-7 and MCF-7/ADR cells)Inhibition of P-gp efflux pump by polymer, lysosomal escape and intracellular drug retention6FA-Chitosan coated nanomicellessiRNA and DoxorubicinMurine breast cancer (4T1, 4T1/MDR cells) and 4T1/MDR xenograft miceElevated intracellular drug accumulation and downregulation of MDR1 gene for the suppression of tumor growth7Thermosensitive HydrogelDoxorubicin and DocetaxelMurine CT-26 cell line and CT-26 xenograft mice modelSustained drug release and enhanced retention and antitumor activity with minimized inherent side effects in mice8Lysine linked d-α-TPGS2000 succinate (PLV2K) nanomicellesDoxorubicinHuman colorectal adenocarcinoma cell line (Caco-2 cells)Elevated intracellular accumulation of doxorubicin by uncompetitive P-gp ATP base inhibition9Polyvinyl caprolactam-polyvinyl acetate-polyethylene micelles (Soluplus®)DoxorubicinHuman breast cancer (MCF-7 and MCF-7/DOX cells) and nude BALB/c miceInhibition pf P-gp drug efflux and alteration in membrane fluidity further enhance the intracellular drug retention and associated toxicity with antitumor activity10PEG-PE/VitaminE nanoemulsionPaclitaxel and curcuminHuman ovarian cancer cell lines (SKOV3 and SKOV3TR cells) and female nude miceBioavailable curcumin inhibits the NF-κB and also acts as an inhibitor for P-gp efflux transporters and elevated intracellular paclitaxel11PCL-PEG nanomicellesDoxorubicin and siHIFProstate cancer (PC-3) cells and xenograft micesiHIF-mediated MDR1 gene silencing, disruption of angiogenesis and enhanced intracellular doxorubicin levels12Pluronic (P-105) based nanomicellesDoxorubicin and RuboxylHuman leukemia cell line (HL-60 cells), Human ovarian cancer cell lines (A2780S and A2780/ADR cells)Surfactant-based nanomicelles facilitate the delivery of drugs to resistant cells and also enhance their intracellular retentionNanoemulsion13NanoemulsionPaeonolHuman colorectal adenocarcinoma (Caco-2 cell lines) and male SD ratsNanoemulsions bypass P-gp efflux pumps and suppress tumor growth14Folate conjugated nanoemulsionDocetaxelHuman epithelial cell lines (KB-WT and KB-PR10 cells) and C57BL/6 J transgenic mouseBypasses efflux pumps and downregulates P-gp efflux with enhanced antitumor activity15Amphiphilic dendrimerDoxorubicinHuman breast Cancer (MCF-7S, MCF-7R cells), Human prostate cancer (PC-3 cells), Human hepatocarcinoma (HepG2 cells), Human cervical cancer (HeLa cells) and Mice models (NSG mice and C57BL/6 mice)EPR-mediated efficient doxorubicin delivery prevents systemic toxicity and overcomes drug resistance16Capryol 90- nanoemulsionPaclitaxelHuman colorectal cancer (Caco-2 cells)Inhibit P-gp efflux and enhance drug retention and associated toxicity17Flaxseed oil-DSPE-PEG2000) nanoemulsionCurcumin and PaclitaxelOvarian cancer (SKOV and SKOV3TR) cellsInhibit NF-κB activity and downregulate P-gp expression with elevated intracellular drug retention18Polyalkylcyanoacrylate NPsCyclosporin A and DoxorubicinMouse leukemia (P388/ADR cells)Inhibition of P-gp efflux pump by cyclosporine A with enhanced doxorubicin retention and associated cytotoxicity Nanomicelles and nanoemulsions used to overcome cancer MDR Nanoemulsions (oil/water) are biocompatible, highly stable nano-size (10–1000 nm) emulsions that are frequently used to entrap and improve the delivery of hydrophobic drugs and pharmaceutically active compounds .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	It is a phenotypically and genetically heterogeneous disease, accounting for 30-40% of all cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "a", "phenotypically", "and...
PMC9429973	Complete remission was achieved by 18/22 (82%) patients with an evaluable remission assessment after the first induction cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Complete", "remission",...
PMC9884169	Among them, there were 201 patients with high expression of MCT4 and poor prognosis (Figure 1(a)) and 201 patients with high expression of MCT4 and poor prognosis (Figure 1(a)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656048	Cell morphology was evaluated using an optical microscope (Olympus Corporation, Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "morphology", "was", "evaluated", "using", "an"...
PMC9351137	Synchronization of the HeLa cells was performed according to Messina et al. .	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Synchronization", "of", "the", "HeLa", "cells", "was", "performed", "accordin...
PMC11342785	Scale bar represents 5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "represents", "5", "μm", "." ] } ]
PMC11286266	Cleavage products were snap-frozen in liquid nitrogen and stored at −80°C for BLI experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cleavage", "products", "were", "snap-frozen", "in", "l...
PMC11739696	Indicates statistical significant difference from the compared untreated control cells at p < 0.01 and 0.001, respectively using independent Student t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indicates", ...
PMC10858941	Furthermore, mibefradil was tested in combination with TMZ in clinical trials, showing good tolerance and positive responses in GBM patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ...
PMC11683240	L and M, different concentrations of α1AT or the respective amount of solvent (H2O) were added directly to CHO-K1 cells in FCS-free medium and incubated for 4 h (L) or 24 h (M) at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC7294030	The IC50 value was calculated from concentration-effect curves after linear regression analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "value", "was", "calculated", "from", "concentration-effect", "curves", ...
PMC11549062	With regard to the relationship between PDGFR‐β and apoptosis, there is controversy among the studies, and this part of the research mainly focuses on the field of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Internalization of AMs reduces AM half-life and decreases cytotoxic capacity of AdCAR-T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Internalization", "of", "AMs", "reduces", "AM", "half-life", "and", ...
PMC11615101	The graph represents the fold change of α-Taxilin based on the normalized densitometric value of WB upon different doses of TNF-α. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graph...
PMC9429973	Results: The primary endpoint is the complete response (CR) rate at Day 29 and key secondary endpoints include Day 29 overall response rate and durable CR rate at Day 99.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8010066	Fig. 1The planktonic (a) and biofilm (b) states of the co-culture of P. aeruginosa—S. aureus on the A549 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC9429973	J. Martínez López, S. Rueda Charro, D. Bermejo Peláez, A. Mousa Urbina, R. Trelles Martínez, M. García Roa, A. Bobes Fernández, M. Hidalgo Soto, M. L. Morales Fernández, A. Ortiz Ruiz, A. Rodríguez García, R. García Vicente, A. Blanco Sánchez, R. Ayala Diaz, L. Lin, E. Álamo García-Donas, E. Dacal Picazo, M. Luengo Oroz, M. Linares Gómez Department of Translational Hematology, Research Institute Hospital 12 de Octubre (i+12); Hematological Malignancies Clinical Research Unit, H120-CNIO, CIBERONC; Spotlab, Madrid; Department of Hematology, Hospital Universitario Fundación Alcorcón, Alcorcón; Department of Hematology, Hospital Clínico San Carlos, Madrid; Vall Hebron Institute of Oncology (VHIO), Barcelona; Department of Hematology, Hospital Universitario 12 de Octubre; Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid; Department of Biochemistry and Molecular Biology, Pharmacy School, Universidad Complutense de Madrid, Madrid, Spain Background: Microscopic examination of bone marrow aspirates (BMA) is still, in almost every organization world-wide, a task that is performed with conventional microscopes relying on an in-person diagnostic process.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11291490

The cells (for qRT-PCR) and supernatant (for ELISA) were collected at 48 h post-stimulation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "(", "for", "qRT-PCR", ...

PMC9841531

The reference ABCB1 inhibitor 34 and the reference ABCG2 inhibitor 36 were procured from Sigma-Aldrich (St. Louis, MO).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reference", ...

PMC7759933

Another important group of phase II enzymes is N-acetyltransferases (NAT) that catalyse the activation of aromatic and heterocyclic amines via O-acetylation, while N-acetylation of the parent amines is considered a detoxification step .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11218145

In fact, by 7 weeks from MPM cell inoculation, 10/10 mice treated with vehicle and 5/10 mice treated with TB were dead.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11457557

It is worth noting that a decline in kidney function is measured by the decline in the eGFR, while glomerular filtration barrier dysfunction, is measured by albuminuria, can occur independently.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: The median age of patients was 37 years (range, 15-84).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "The", "median", "age", "of"...

PMC11401350

Conversely, CD4-LV mediated the exclusive generation of CD4CAR T cells, which were equally active in eliminating tumor cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "CD4-LV", ...

PMC9429973

Of the 37 patients who started ponatinib due to intolerance to previous TKIs, 59% (15 CML, 7 Ph+ALL) achieved MMR.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11695623

We used R software to analyze the differential genes between DCUN1D5 high expression group and low expression group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "R", "software", "to", ...

PMC11787381

In Aβ1-42-injected mice, daily bambuterol (300 µg/kg/d) increased synaptophysin (p < 0.05, versus Aβ1-42- injected mice treated with the vehicle) (Fig. 8A) and PSD95 (p < 0.10) protein levels (Fig. 8B) indicating a protective effect on synapses.

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PMC9429973

In our pilot study we observed similar response rate though it was not a randomized data.

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PMC11013014

HRMS (+ESI) m/z: [M + H] calculated for C23H19Cl2N6O3: 497.0890, found: 497.0887.

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PMC10362265

Orange and blue colors mark the left and right interfaces, respectively.

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PMC11675244

However, with such fundamental implications in basic cellular processes, these signaling networks are often prone to malfunctioning into human malignancies.

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PMC11507371

Different studies showed that RNS can act either as an activator of NF-κB signalling via degradation of IκBα or repress NF-κB signalling through nitration on tyrosine residues of p65, leading to its destabilisation, nuclear export, and inactivation of NF-κB activity .

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PMC6222635

It was obvious that molecular weight played an important role in anti-tumor activities.

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PMC9429973

We aimed to dissect expression of crucial regulatory and signalling factors in thymus tissue samples and interpret them in the context of known healthy thymus characteristics.

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PMC4277423

After successfully disrupting CCR5 gene in human T cell lines, we have made several attempts to disrupt CCR5 gene in human primary T cells from multiple donors with lentiviral vectors expressing Cas9 and sgRNA CR2, including a single lentiviral transfer construct that co-expresses Cas9 and sgRNA CR2 along with GFP marker protein.

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PMC10213179

Conducting the two SELEX strategies independently of each other and then bioinformatically comparing them using the clustering algorithm has two distinct advantages over integrated SELEX strategies such as Toggle SELEX.

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PMC9684669

Immunoblot analysis was performed with indicated antibodies and the chemiluminescence signal was visualized with Luminata Forte Western HRP substrate (EMD Millipore) in a BioSpectrum system (UVP, LLC).

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PMC11699042

e Relative variation in cell viability for each EwS cell line measured as the mean area under the curve (AUC) m12 vs. m0 for the extended drug library (20 compounds).

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PMC11612626

A limitation to the development of CAR T-cell therapies is the requirement for a distinct tissue-restricted target antigen on the tumor cell surface.

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PMC11591030

Compared to the CON and AOP groups, the LPS group significantly upregulated the gene expression of the NF-κB signaling pathway-related factors and decreased the expression of the IkBα gene (p < 0.05).

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PMC11185260

For RT-qPCR, total RNA was extracted from the cell pellets using the PureLink RNA mini kit (Thermo Fisher) and reverse-transcribed using an iScript cDNA synthesis kit (Bio-Rad, Hercules, CA, USA).

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PMC11300085

Chemerin induces metastasis of gastric cancer cells via CMKLR1 and CPR1/TIMPs pathways .

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PMC9429973

In the remaining 116 patient pairs remdesvir significantly reduced the mortality: 36 out of 106 treated patients died, in comparison to 54 untreated (p=0.0207, McNemar’s test).

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PMC4277423

Although these studies showed that CCR5 gene disruption can be generated in 293 and K562 cells and iPSCs and modified iPSCs, when differentiated into monocytes/macrophages, were resistant to HIV-1 challenge, the efficiency and the specificity of individual sgRNAs that target different CCR5 sequence segments in human CD4 T cells, the major cell targets for HIV-1, remain to be carefully evaluated.

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PMC11297139

Lastly, we studied the concentration-related formation of nuclear ARID1A condensates by tracking the nucleoplasmic concentrations at which ARID1A proteins started to form condensate.

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PMC11742290

LGR5 protein expression was decreased in glioblastoma cancer cells (U87) when treated with increasing concentrations of TCS in vitro .

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PMC11075223

The following keywords were retrieved from these websites, including “Cimicifugae Rhizoma”, “Cimicifuga”, “C. heracleifolia”, “C. dahurica”, “C. foetida”, “cohosh”, “ethnopharmacological use”, “triterpenoid saponins”, “phenylpropanoids”.

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PMC11622247

With the brighter light-harvesting probe JK2 it was possible to observe a population of Jurkat cells that exhibited fluorescence levels exceeding those observed in mock microporation (Fig. 6A).

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PMC7215832

We investigated the mechanism and potential of RX-3117 as a demethylating agent in several in vitro models. (

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PMC11434983

Briefly, 50 μL (~74 kBq) of the isolated complex was added to a centrifuge tube containing 4 mL of a 1-octanol/PBS (0.1 M, pH 7.4) (1:1) mixture.

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PMC9118379

SpecOMS: minimum peptide length = 7, maximum peptide length = 50, threshold = 6, max masses count = 100, minimum peptide charge = 1, maximum peptide charge = 7, number of decimals = 2, decimal value = 4, decoy base = false.

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PMC11257203

P < 0.001 Indicates significant differences compared to the control group; P < 0.05 and P < 0.01 between the designated groups.

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PMC11759543

The combination of vorinostat and other drugs may enhance the anti-cancer effect.

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PMC9429973

Despite a high rate of response to induction chemotherapy, only 30–40% of adult patients with ALL will achieve long-term remission.

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PMC11092382

The underlying mechanism may be attributed to the modulation of TLR4 expression and NF-κB and MAPK activation (Lu et al., 2019).

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PMC11300639

The siRNAs were obtained from RiboBio (Guangzhou, China).

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PMC11699042

g Combined transcriptomic PCA of our A-673 and HeLa datasets and that of Liu et al. (HeLa_Liu) (N = 13,569 transcripts).

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PMC10874773

Ye Jin: Data curation, Formal analysis, Visualization, Writing – original draft.

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PMC11521786

This work presents a new vaccine candidate that comprises the extracellular domain (ECD) of HER3 (HER3-ECD) as an antigen vaccine.

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PMC10443665

Tragacanthin-induced chemosensitivity of CCRF-CEM and CCRF-CEM/R cells to MTX could be related to its effect on the down-regulation of MDR1 mRNA expression.

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PMC11676674

The relaxing effects of C. monspeliensis aerial parts on isolated vascular and intestinal smooth muscle in vitro also have been established .

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PMC9429973

Karpas-299 cells genetically-manipulated to express RIPK3 were used to demonstrate involvement of necroptosis in drug-induced cell death (Cytotox NIR) in vitro.

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PMC9587298

The results obtained in this work show for the first time that phenolic compounds present in elderberry have antiglycation activity by trapping MGO.

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PMC10606998

Figure 5e,f show photographs of plates with stained cell colonies obtained in one of the experiments, illustrating the effect of sensitization by nanoparticles.

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PMC8526701

A Indicated cell lines were transfected with siRNA against BRD9 for 24 h, BRD9 protein level was analyzed by western blotting.

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PMC11514418

The results of a meta-analysis also showed that APS-based TCM decoction can increase the effectiveness and reduce the toxicity of platinum-based chemotherapy for advanced non-small cell lung cancer in randomized clinical trials.

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PMC11705484

5637 cells were transfected with pGL3‐luciferase reporter constructs encoding empty vector (NC), wild type TRMT61A promoter with both of the two NF‐κB binding sites (wt‐TRMT61A), wild type TRMT61A promoter with NF‐κB binding site 1 only (wt‐TRMT61A‐site 1) or site 2 only (wt‐TRMT61A‐site 2), or mutant TRMT61A promoter with mutations at the NF‐κB binding site 1 (mut‐TRMT61A‐site 1) or site 2 (mut‐TRMT61A‐site 2) for 48 h. Firefly luciferase activity was measured and normalized to Renilla luciferase activity. (

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PMC10976516

And, even so, only induction of a powerful anti-tumor response through OV’s immunotherapeutic effect can guarantee lasting remission of most if not all metastatic lesions.

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PMC10778532

We asked whether if VHL-C162F mutation can impact healing abilities by a scratch test of wound healing assay at high confluence (Figure 1I).

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PMC10728200

We then constructed the point mutation plasmids by mutating the lysine (Lys) to the arginine (Arg), which cannot be modified by ubiquitination, and performed CO-IP experiments.

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PMC11762280

N-GSDMDcleaved PARPp-MLKLAgeHuman non-exposed areaPearson’s rN-GSDMD10.6720.5540.557cleaved PARP0.67210.5470.476p-MLKL0.5540.54710.677Age0.5570.4760.6771P (one-tailed)N-GSDMD–0.0080.0310.03cleaved PARP0.008–0.0330.059p-MLKL0.0310.033–0.008Age0.030.0590.008–Human sun-exposed areaPearson’s rN-GSDMD10.716−0.0480.595cleaved PARP0.7161−0.1320.717p-MLKL−0.048−0.1321−0.1Age0.5950.717-0.11P (one-tailed)N-GSDMD–0.0040.4410.021cleaved PARP0.004–0.3420.004p-MLKL0.4410.342–0.378Age0.0210.0040.378– Linear regression analysis of N-GSDMD, cleaved PARP, p-MLKL and age.

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PMC10747160

Once flask medium reached an optical density at 600 nm (OD600) of 0.50 to 0.75, protein production was induced with 0.6 mM of isopropyl β-d-1-thiogalactopyranoside (IPTG, Millipore Sigma OmniPur–Calbiochem, Catalog # 5820, Burlington, MA, USA) and allowed to further incubate at 37 °C for 6 to 10 h. After incubation, cells were harvested at 6000× g for 10 min, and the pellet was resuspended in Resuspension Buffer (6 M Guanidine hydrochloride, 200 mM NaCl, 10 mM Benzamidine, and 50 mM Tris, pH 8).

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PMC9429973

The median age was 41 (range 17-57) and sex ratio was 1.5 (22M/12F).

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PMC11720107

Foetal bovine serum (FBS), a Universal RNA Purification Kit (E3598-02), and quantitative PCR (qPCR) master mix (Fast Probe qPCR Master Mix) were obtained from EURx (Gdańsk, Poland).

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PMC11755519

EVs can help cancer cells excrete cytotoxic drugs.

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PMC3203927

In Table 2 we list 16 cytokines selected by stepwise discriminant analysis with a cut off p-value of 0.01.

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PMC8524093

Humoral response is also very important to virus depuration.

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PMC11618052

The author reported no potential conflicts of interest(s).

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PMC11300639

Moreover, we noticed a similar effect on changes in VEGFA and p-S6K1 (T389) levels: knockdown of RNF26 in ccRCC cells altered the sensitivity to palbociclib and everolimus (Supplementary Fig. 6e–h).

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PMC3931643

Quantitative RT-PCR showed no significant differences in mRNA expression for MCL-1 or cyclin D3 at these time points (Fig. S5), supporting the conclusion that mTOR inhibition decreases MCL-1 protein in the OCI-LY1 and OCI-LY7 cell lines at the translational level.

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PMC10094992

NR6 treatment prevented neutrophil recruitment by exerting its effect on tumour cells, as neutrophils did not express ALDH1A3 and were insensitive to its inhibition.

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PMC9429973

The primary endpoint is overall response rates (ORR).

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PMC7185206

Clinical studies are warranted to validate these findings in patients.

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PMC11612626

A hallmark of cancer is the ability to evade immunosurveillance by disrupting the antigen presentation machinery and downregulating MHC-I antigen presentation.

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PMC11680049

Cytotoxicity of the extracts was evaluated after 72 h of exposure at concentrations ranging from 7.5 to 1000 µg/mL. At the end of the experiment, cells were incubated for 3 h in the presence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT, DiaM, Moscow, Russia) at a concentration of 0.5 mg/mL. The resulting formazan crystals were dissolved in 100% DMSO.

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PMC9429973

Both genes were highly expressed across the entire cohort.

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PMC8316344

Indeed, knocking TFRC out and overexpressing βTrCP both reduced cell proliferation in SK-Hep1 cells (Fig. 7E).

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PMC11637276

While 50 μM ERK1/2 inhibition reduced ECM internalisation, inhibition of MEK1/2, an upstream activator of ERK1/2, did not reduce ECM uptake at effective inhibitory concentrations starting from 10 μM (S5B Fig).

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PMC11697189

The asterisks represented the statistical p value (*: P < 0.05; **: P < 0.01; ***: P < 0.001).

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PMC7887261

RNeasy mini kit (Qiagen #74106) was used to extract total RNA from cells 72 h post siRNA transfection or protein overproduction.

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PMC11661024

Lactobacillus fermentum species are the dominant constituent of the gastrointestinal tract microbiome and enhance vaginal tract health by reducing infection risks .

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PMC11629461

Photodynamic action (450 nm, 85 mW/cm, 1.5 min) with the in‐frame miniSOG of construct miniSOG‐NOX5 was found to similarly elicit persistent Ca oscillations, which were inhibited completely by pretreatment with DPI 10 μM, and blocked completely by O2 quencher Trolox‐C (Figure 4).

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PMC10914904

This review aims to provide insights into vtRNA biology, interactions with innate immune system proteins, roles in antiviral responses and immunological diseases, and involvement in other cellular processes, including potential contributions to pathways such as NF-kB activation.

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PMC11680049

It is possible that the active biosynthesis and accumulation of terpenoids and polyphenols in the vascular and associated tissues also represent a certain adaptive component that helps the plant organism overcome stress factors that arise with increased height .

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PMC9429973

Results: For the early post-cycle 4 timepoint, there was low agreement between NGS (sensitivity threshold 10) and MS; there was 46% agreement (Cohen’s kappa -0.18) between NGS and EXENT and 54% agreement (Cohen’s kappa -0.15) between NGS and LC-MS.

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PMC8873393

Cyt, cytoplasm; Chr, chromatin.

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PMC8557138

Bayat et al. engineered a HUVEC vascularized 3D tumor model of glioblastoma to test the efficacy of the drug atorvastatin.

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PMC9429973

This was also the case in GVHD target organs, including liver and lungs.

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PMC11774747

Factors such as the persistence of CAR-VSTs in the blood, their expansion in response to viral reactivation, and their residency at tumor sites are critical to achieve sustained antitumor activity.

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PMC9509578

NoNanoparticles (NPs)Chemotherapeutic drugsExperimental modelMechanism of actionRefsNanomicelles1TAT-TPGS-PEG-b-P(ALA) nanomicellesDoxorubicinHuman breast cancer (MCF-7 and MCF-7/ADR cells)Inhibition of P-gp efflux pump and intracellular drug retention and enhanced cytotoxicity2Folic acid conjugated P(OEGMA300)-st-P(HEMA-g-LA) nanomicellesDoxorubicinHuman cervical cancer (HeLa cells)Enhanced intracellular drug accumulation and tumor microenvironment-triggered drug release and cytotoxicity3Polycarbonate based NO nanomicellesDoxorubicinHuman breast cancer (MCF-7/DOX cells)Nitric oxide-mediated P-gp inhibition, intracellular drug accumulation and cytotoxicity4Nitrate functionalized TPGS nanomicellesDoxorubicin, adjudin and nitric oxideHuman breast cancer (MCF-7/ADR cells), murine mammary carcinoma (4T1 cells) and BALB/c miceControlled drug release, enhanced cytotoxicity, P-gp inhibition, reduction in tumor growth and reversal of MDR5Poly (β-amino ester) polymer-based nanomicellsDoxorubicinHuman breast cancer (MCF-7 and MCF-7/ADR cells)Inhibition of P-gp efflux pump by polymer, lysosomal escape and intracellular drug retention6FA-Chitosan coated nanomicellessiRNA and DoxorubicinMurine breast cancer (4T1, 4T1/MDR cells) and 4T1/MDR xenograft miceElevated intracellular drug accumulation and downregulation of MDR1 gene for the suppression of tumor growth7Thermosensitive HydrogelDoxorubicin and DocetaxelMurine CT-26 cell line and CT-26 xenograft mice modelSustained drug release and enhanced retention and antitumor activity with minimized inherent side effects in mice8Lysine linked d-α-TPGS2000 succinate (PLV2K) nanomicellesDoxorubicinHuman colorectal adenocarcinoma cell line (Caco-2 cells)Elevated intracellular accumulation of doxorubicin by uncompetitive P-gp ATP base inhibition9Polyvinyl caprolactam-polyvinyl acetate-polyethylene micelles (Soluplus®)DoxorubicinHuman breast cancer (MCF-7 and MCF-7/DOX cells) and nude BALB/c miceInhibition pf P-gp drug efflux and alteration in membrane fluidity further enhance the intracellular drug retention and associated toxicity with antitumor activity10PEG-PE/VitaminE nanoemulsionPaclitaxel and curcuminHuman ovarian cancer cell lines (SKOV3 and SKOV3TR cells) and female nude miceBioavailable curcumin inhibits the NF-κB and also acts as an inhibitor for P-gp efflux transporters and elevated intracellular paclitaxel11PCL-PEG nanomicellesDoxorubicin and siHIFProstate cancer (PC-3) cells and xenograft micesiHIF-mediated MDR1 gene silencing, disruption of angiogenesis and enhanced intracellular doxorubicin levels12Pluronic (P-105) based nanomicellesDoxorubicin and RuboxylHuman leukemia cell line (HL-60 cells), Human ovarian cancer cell lines (A2780S and A2780/ADR cells)Surfactant-based nanomicelles facilitate the delivery of drugs to resistant cells and also enhance their intracellular retentionNanoemulsion13NanoemulsionPaeonolHuman colorectal adenocarcinoma (Caco-2 cell lines) and male SD ratsNanoemulsions bypass P-gp efflux pumps and suppress tumor growth14Folate conjugated nanoemulsionDocetaxelHuman epithelial cell lines (KB-WT and KB-PR10 cells) and C57BL/6 J transgenic mouseBypasses efflux pumps and downregulates P-gp efflux with enhanced antitumor activity15Amphiphilic dendrimerDoxorubicinHuman breast Cancer (MCF-7S, MCF-7R cells), Human prostate cancer (PC-3 cells), Human hepatocarcinoma (HepG2 cells), Human cervical cancer (HeLa cells) and Mice models (NSG mice and C57BL/6 mice)EPR-mediated efficient doxorubicin delivery prevents systemic toxicity and overcomes drug resistance16Capryol 90- nanoemulsionPaclitaxelHuman colorectal cancer (Caco-2 cells)Inhibit P-gp efflux and enhance drug retention and associated toxicity17Flaxseed oil-DSPE-PEG2000) nanoemulsionCurcumin and PaclitaxelOvarian cancer (SKOV and SKOV3TR) cellsInhibit NF-κB activity and downregulate P-gp expression with elevated intracellular drug retention18Polyalkylcyanoacrylate NPsCyclosporin A and DoxorubicinMouse leukemia (P388/ADR cells)Inhibition of P-gp efflux pump by cyclosporine A with enhanced doxorubicin retention and associated cytotoxicity Nanomicelles and nanoemulsions used to overcome cancer MDR Nanoemulsions (oil/water) are biocompatible, highly stable nano-size (10–1000 nm) emulsions that are frequently used to entrap and improve the delivery of hydrophobic drugs and pharmaceutically active compounds .

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PMC9429973

It is a phenotypically and genetically heterogeneous disease, accounting for 30-40% of all cases.

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PMC9429973

Complete remission was achieved by 18/22 (82%) patients with an evaluable remission assessment after the first induction cycle.

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PMC9884169

Among them, there were 201 patients with high expression of MCT4 and poor prognosis (Figure 1(a)) and 201 patients with high expression of MCT4 and poor prognosis (Figure 1(a)).

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PMC11656048

Cell morphology was evaluated using an optical microscope (Olympus Corporation, Tokyo, Japan).

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PMC9351137

Synchronization of the HeLa cells was performed according to Messina et al. .

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PMC11342785

Scale bar represents 5 μm.

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PMC11286266

Cleavage products were snap-frozen in liquid nitrogen and stored at −80°C for BLI experiments.

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PMC11739696

Indicates statistical significant difference from the compared untreated control cells at p < 0.01 and 0.001, respectively using independent Student t-test.

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PMC10858941

Furthermore, mibefradil was tested in combination with TMZ in clinical trials, showing good tolerance and positive responses in GBM patients .

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PMC11683240

L and M, different concentrations of α1AT or the respective amount of solvent (H2O) were added directly to CHO-K1 cells in FCS-free medium and incubated for 4 h (L) or 24 h (M) at 37 °C.

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PMC7294030

The IC50 value was calculated from concentration-effect curves after linear regression analysis.

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PMC11549062

With regard to the relationship between PDGFR‐β and apoptosis, there is controversy among the studies, and this part of the research mainly focuses on the field of cancer.

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PMC9429973

Internalization of AMs reduces AM half-life and decreases cytotoxic capacity of AdCAR-T cells.

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PMC11615101

The graph represents the fold change of α-Taxilin based on the normalized densitometric value of WB upon different doses of TNF-α. (

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PMC9429973

Results: The primary endpoint is the complete response (CR) rate at Day 29 and key secondary endpoints include Day 29 overall response rate and durable CR rate at Day 99.

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PMC8010066

Fig. 1The planktonic (a) and biofilm (b) states of the co-culture of P. aeruginosa—S. aureus on the A549 cell line.

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PMC9429973

J. Martínez López, S. Rueda Charro, D. Bermejo Peláez, A. Mousa Urbina, R. Trelles Martínez, M. García Roa, A. Bobes Fernández, M. Hidalgo Soto, M. L. Morales Fernández, A. Ortiz Ruiz, A. Rodríguez García, R. García Vicente, A. Blanco Sánchez, R. Ayala Diaz, L. Lin, E. Álamo García-Donas, E. Dacal Picazo, M. Luengo Oroz, M. Linares Gómez Department of Translational Hematology, Research Institute Hospital 12 de Octubre (i+12); Hematological Malignancies Clinical Research Unit, H120-CNIO, CIBERONC; Spotlab, Madrid; Department of Hematology, Hospital Universitario Fundación Alcorcón, Alcorcón; Department of Hematology, Hospital Clínico San Carlos, Madrid; Vall Hebron Institute of Oncology (VHIO), Barcelona; Department of Hematology, Hospital Universitario 12 de Octubre; Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid; Department of Biochemistry and Molecular Biology, Pharmacy School, Universidad Complutense de Madrid, Madrid, Spain Background: Microscopic examination of bone marrow aspirates (BMA) is still, in almost every organization world-wide, a task that is performed with conventional microscopes relying on an in-person diagnostic process.

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