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BioData-CellLine_annotated

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PMC8526701
B BRD9 protein expression in GISTs and adjacent nontumor tissues was examined by western blotting.
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PMC11726848
Such multifaceted theoretical causality of the irradiation outcomes under HDR and LDR irradiations, and the actual scarcity of information about the distinction between the underlying mechanisms of each, especially for corpuscular radiation, inspires new research endeavors.
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PMC11718274
The impact of Y2O3NPs on integrity of mitochondrial membrane potential was also studied using Rhodamine-123 fluorescent dye.
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PMC9429973
Extension assessment: it was localized forms (IE, II1E) in 50% of cases and disseminated forms (Ii2E to IV) in 47.5% of cases.
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PMC11700165
Statistical analysis was performed using GraphPad Prism10 Software.
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PMC8903741
However, the use of other CHO cell culture media, such as ActiCHOP, BalanCD CHO , can be attempted to improve the yields.
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PMC11640476
LoD and LoQ, estimated starting from 2D data, were found to be ~8.8 × 10 cells/cm and ~2.64 × 10 cells/cm, respectively.
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PMC11462673
Novelty and Limitation Our study has revealed a novel mechanism through which LDB1 drives the progression of T-cell acute lymphoblastic leukemia (T-ALL).
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PMC11218145
Our results suggest that TB could also modulate the ER-mitochondrial Ca transmission, as demonstrated by increased accumulation of Ca in both mitochondria and cytosol.
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PMC11767793
In all instances, the cellular viability dropped rapidly upon the increase of the Au-PEI@NIST concentration, with the IC50 in the range from 1.49 μg/mL to 4.7 μg/mL for these cell lines.
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PMC8343815
Moreover, radiation sources with different energies may alter the radiosensitizing effect of gold nanomaterials .
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PMC11463018
White solid, 67.8% yield.
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PMC9429973
Results: Fifty-eight SHA boys were finally analyzed.
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PMC9952933
For detecting apoptosis, a caspase-3/7 assay and a TUNEL assay were used.
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PMC11704834
Preparation of the mitochondrial, cytoplasmic and nuclear containing fractions was conducted using the Cell Fractionation Kit (Abcam).
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PMC11095939
NIH3T3 cells were transfected with Mecp2 or Nedd4 plasmid using Lipofectamine 3000 in serum-free medium for 12 hr, then the medium was removed and replaced with DMEM containing 10% FBS for 24 hr.
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PMC11225860
Fig. 5Aurkin A prevents alisertib induced cell cycle slippage and endomitosis.
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PMC11216402
We used a machine learning approach, gkm-SVM (Ghandi et al. 2014a; Lee et al. 2015; Beer et al. 2020), to identify the sequence features (transcription factor binding sites [TFBSs]) driving these variations in chromatin accessibility.
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PMC11705067
The data indicated that FDX1 was assigned only one agent named mitotane, whereas NADH, radicicol and dihydrolipoic acid are potential drug targets for DLAT (Fig. 9A, 9B).
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PMC9429973
Median number of cycles received was 6 (range, 1-7) Baseline parameters are described in Table 1.
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PMC11087055
Blue, clockwise; red, counter-clockwise rotation.
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PMC9429973
The ART allows treating HIV-infected patients with lymphomas with protocols for patients in the general population.
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PMC11727062
For instance, research has shown that β-elemene can counteract resistance to 5-fluorouracil in P53-deficient HCT116p53-/- cells.
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PMC11347429
Mortality in severe cases is primarily driven by a pathological immune response characterized by high levels of neutrophils, macrophages, and inflammatory cytokines (7, 9–13).
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PMC11627060
The results of the study on salicylic acid-loaded protein nanomaterials provide supportive evidence for the findings from UV-Vis spectroscopy, indicating that the drug-binding site on BSA is a lipophilic pocket composed of positively charged surfaces.
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PMC11742047
The analysis of shared alterations between both cell lines (Fig. 6B) clearly demonstrates a more significant alteration in lipid levels in the K-562 cell line, exhibiting more pronounced Log2(fold change) values compared to the HL-60 cell line.
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PMC9428827
In the present work, we extended the demonstration of the antitumor capacity of no-alpha mutein to four primary tumor models and survival induction in two spontaneous metastases models.
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PMC10812665
This iron release has been found to be important for dopaminergic neuron death and differentially affected by various toxicants .
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PMC10778532
These observations have to be considered to design the best treatment for patients with VHL-C162F disease.
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PMC11604768
Transcription factors bind to specific DNA sequences known as transcription response elements (TREs) to initiate gene transcription.
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PMC11522251
As a member of the ErbB family, HER2 amplification can generate resistance to EGFR antibodies by bypassing stimulation of the MEK-ERK signaling pathway regardless of EGFR signaling .
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PMC9429973
With increasing awareness among physicians and availability of proper diagnostics, more cases of AL amyloidosis are being diagnosed.
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PMC11322866
RPMI-8226 and OCI-MY5 cells were examined by immunofluorescence with DAPI (blue).
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PMC11699465
The Supernatant after centrifugation at 12500 rpm for 10min was used as input.
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PMC9583612
However, no empirical measurement protocol has been demonstrated to provide reasonably accurate supply chain-specific methane emission estimates necessary to assess target-based emission reduction claims.
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PMC7823217
Figure A is reproduced from with the permission of Springer Nature.
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PMC5916734
This domain ensures binding of FIX and FIXa to the surface of endothelial cells .
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PMC11803149
CD8 T cells were then resuspended in complete RPMI-1640 media containing 2 mM L-glutamine, 1% HEPES (Life technologies; 15630080), 1 mM sodium pyruvate (Thermo Fisher, 11360070), 10 mM MEM non-essential amino acids (Thermo Fisher, 11140050), 0.05 mM 2-mercaptoethanol (Gibco, 21985-023), 10% fetal bovine serum (FBS) (Nichirei Bioscience, 173012) and 1% penicillin and streptomycin.
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PMC11694625
In addition, we noticed that 3c showed stronger antiproliferative activity than 3a against all the selected cancer cell lines.
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PMC9275501
The unique micelle structure allowed the simultaneous loading of hydrophilic DOX and hydrophobic CUR, and the loading efficiency of each drug was above 98 %.
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PMC7519871
3D and (B) 2D poses of WDL with Nuclear factor kappa-light-chain-enhancer Protein of activated B cells (NF-kB) PDB ID: 2RAM. (
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PMC11380454
In addition to PD-L1 in malignant cells interfering with cytotoxic T-cell function, of the binding of PD-L1 to PD-1 increases tumor cell resistance to conventional chemotherapy and increases tumor cell proliferation and survival 6.
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PMC11509224
These three cyanthiwigin-type diterpenes, named erectcyanthins A–C (140–142, Figure 13), were isolated from the marine sponge Hyrtios erectus .
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PMC10170482
HepG2 and Alexander cells were grown either in a standard monolayer culture (MC) or in collagen scaffolds (CSs).
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PMC11632064
Heat-map of Log2 fold change of specific transcripts linked to phenotype switching in MeWo cells treated with BI-D1870 (3 μM) for 72 h. Derived from RNA-seq analyses in Fig 2. (
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PMC11307990
Renal carcinoma is the second most common malignancy of the urinary system, which is classified pathologically into clear cell carcinoma, papillary cell carcinoma, and chromophobe cell carcinoma.
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PMC11653533
It has various spreading branches, but the trunk seldom develops to a distance across more noteworthy than 7 in.;
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PMC9352806
The membranes were then blocked and probed with antibodies against AMPK, p-AMPK, LC-3B and β-actin (Cell Signaling Technology, Inc., USA), and incubated with the membranes at 4 °C overnight.
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PMC11529598
p < 0.05 Expression of miR-3154 was elevated in human glioblastoma tissue and cell lines.
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PMC10823017
The cells were serum starved in a T75 flask for 24h Next, the cells were detached from the flask’s surface by using trypsin for two minutes, and they were re-suspended in a 10% serum-containing media before being plated (5 X 10) into the upper chamber of the 24 wells Transwell permeable support (pore size: 8μm) that had been coated with 250µg/ml of Basement Membrane Extract (BME) solution.
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PMC7723249
Accordingly, we showed that only CCHFV infection of moDCs induced a significant production of IL-6, IL-10 and TNF-α in comparison to the non-pathogenic HAZV (Fig 4).
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PMC11656657
Spheroid diameter and GFP expression of residual tumor have been analyzed in real time starting 12 h after co-culture up to 120 h (5 days).
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PMC11574271
Through a series of experiments, we obtained results demonstrating that aberrant RON expression and signaling are critical in regulating bladder cancer cell malignant activities.
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PMC8316344
Labile iron was measured by Iron Assay Kit (E) in Bel-7404 cells with or without single or double knockout (DKO) of TRIB2 and TFRC in basal condition or following treating with RSL3 (5 µM, 12 h) or erastin (10 µM, 12 h).
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PMC10329074
A and B) Invasion of A498 cells were discovered by way of Transwell assay. (
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PMC11657744
Fig. 4CEP89 and FBF1 promote ciliary disassembly by regulating Aurora A kinase. (
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PMC10142392
Hence, these copolymers present a revolutionary way that will completely change how we treat illnesses by enhancing treatment efficacy and minimizing negative effects.
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PMC11463018
H NMR (500 MHz, DMSO-d6) δ: 11.12 (s, 1H), 8.96 (s, 1H), 7.67 − 7.62 (m, 3H), 7.58 − 7.50 (m, 4H), 7.49 − 7.45 (m, 1H), 7.36 (d, J = 8.1 Hz, 2H), 7.29 (t, J = 6.4 Hz, 1H), 6.93 − 6.90 (m, 1H), 4.43 (d, J = 6.4 Hz, 2H).
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PMC9429973
It has been reported in several studies that the C677T and A1298C polymorphisms of the MTHFR may play a role in the pathophysiology of acute leukaemias and various other types of signalopathies such as cancers.
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PMC11687663
The protein was selected on the basis of biological relevance, availability of a known 3D structure (resolution = 2.20 Å), and relevance to the research question (non-mutated).
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PMC9429973
However, the role of the T cells’ repertoire in therapy outcome still remains unclear.
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PMC11770199
Plasmid of pCW57-p14 was transfected into hMSCs and mixed with A375 and MV3 cells (expressing GFP).
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PMC11763111
F Flow plots show the memory phenotype of CAR-T cells, TN, naive, CD62LCD45RA; CM, central memory, CD62LCD45RA; EM, effector memory, CD62LCD45RA; TE, terminal effector, CD62LCD45RA.
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PMC11487720
As positive controls, staurosporine at 1 μM induced DNA fragmentation at 37 °C but not at 22 or 4 °C (Fig. S2J, K).
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PMC11534035
A431 colonies treated with 1 μM G1, showed no significant impact on colony size.
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PMC8409415
On univariate analysis, CD70 expression was not associated with age, stage, residual disease, or serum CA‐125 levels (all P > .05).
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PMC11661024
The expression quantities of apoptosis-related genes (RelA, Casp9, Casp8, BAX/Bcl2, and IKB) in HeLa and HUVEC cell lines were determined using SYBR Green PCR Master mix with semi-quantitative RT-PCR (BioRad, USA).
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PMC4443654
Instead, we found that variable regions preferentially interact with other A compartment regions in the cell types in which they are active (Figure 5B, Additional file 1: Figure S11), but not in the other cell types in which they are inactive.
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PMC9429973
Estradiol and progesterone were not affected throughout the treatment.
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PMC11045125
D. Extracts from Donor 1 derived tumors with or without Myc expression were examined for expression of Myc, the EBV LMP1 protein, DNMT3B protein, DNMT1 protein and UHRF1 protein as indicated.
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PMC9895440
n = 7 mice for CART-treated mice of n = 1 experiment.
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PMC9545474
The populations of the ΔΨm depleted cells were comparable for complex 8 and cisplatin, and complex 6 induced higher increases of A2780 cell populations with depolarised mitochondria.
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PMC11547972
The number of cancer patients in Sweden and Germany integrating CAM into their treatment schedules has been estimated to be between 50 and 70% .
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PMC11615828
Fluorescence Recovery After Photobleaching (FRAP) was performed using a confocal laser scanning microscope equipped with a 60x oil objective (Zeiss LSM780).
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PMC7602170
eIF4E is a cap-binding protein that recognizes and binds to the mRNA 5′ mG cap structure, which interacts with the DEAD box RNA helicase eIF4A and the scaffolding protein eIF4G.
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PMC11449273
p < 0.05, **p < 0.001.
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PMC11547972
Amygdalin reduced cdk1 (A498, Caki-1), pcdk1 (all cell lines), cdk2 (A498, KTCTL-26), pcdk2 (A498), Cyclin A (all cell lines), Cyclin B (A498, Caki-1), pAkt (KTCTL-26), and Bcl-2 (Caki-1).
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PMC9429973
After median follow-up of 6 month (2-14m), the estimated PFS rate is 88.2%（95%,CI 81.7-94.7, Figure 2）.Totally four patients progressed during or shortly after the induction therapy.
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PMC11590005
Data were collected from November 2021 to July 2022.
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PMC9429973
Treatment was discontinued early due to toxicity in 11 patients (28%) with a median number of 6 (2-6) chemotherapy cycles in the overall cohort.
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PMC11529598
Cells were incubated for 48 h, and relative luciferase activity was measured using Renilla luciferase activity as internal reference.
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PMC9250505
BCL2–associated death promoter (BAD) protein is a BH3-only member of the BCL-2 family of proteins.
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PMC9878278
While the antiviral activity of BMP6 has not been explored in ZIKV and other flaviviruses, a recent study reported activation of BMP2 maturation in ZIKV-infected brain pericytes that led to osteogenic gene expression and calcification (Chen et al., 2021).
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PMC11286266
All cells were grown in a humidified 37°C incubator with 5% CO2 and passed every 2–3 days.
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PMC9599726
Unfortunately, most patients ultimately progress due to primary or secondary mutations of KIT or PDGFRA.
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PMC9429973
Data from the 50 mg MAD cohort are reported in this analysis.
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PMC9786247
To release bacteria from inside the cells, the cells were frozen (−80 °C) and thawed three times and subsequently incubated for 30 min at 95 °C to inactivate the bacteria.
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PMC11055323
two-sided, unpaired t-test, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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PMC4695073
Human NPC HONE1, CNE1 and CNE2 cells were cultured respectively in RPMI1640 medium containing 10% FBS and maintained in a humidified atmosphere with 5% CO2 at 37°C.
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PMC9429973
To confirm the importance of protein folding process in acute myeloid leukemia, we tested the effect of ERO1 inhibitor (EN460), and found it to have a greater impact in FLT3-ITD cell lines.
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PMC11696576
Red and blue dots indicate genes that are expressed differentially with an adjusted P-value < 0.01, while grey dots represent genes that are not.
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PMC9429973
N. Cooper, W. Ghanima, N. Vianelli, D. Valcárcel, I. Yavaşoğlu, A. Melikyan, E. Yañez Ruiz, J. Haenig, J. Lee, J. Maier, N. Zolkin, F. Zaja Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, Hammersmith Hospital, London, United Kingdom; Department of Medicine, Østfold Hospital Trust, Kalnes, Norway; Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Hematology, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain; Department of Hematology, Adnan Menderes University, Aydin, Turkey; National Research Center for Hematology, Moscow, Russia; Hematology-Oncology Unit, Department of Internal Medicine, School of Medicine, Universidad de la Frontera, Temuco, Chile; Novartis Pharma AG, Basel, Switzerland; Novartis Pharmaceuticals Corporation, East Hanover, NJ, United States of America; IQVIA, St. Petersburg, Russia; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy Background: Corticosteroids (CSs) are the standard 1-line treatment for primary immune thrombocytopenia (ITP); however, long-term CS use is associated with high relapse rates and considerable toxicity.
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PMC10852540
The response rate to treatment is about 80–90%, but most often relapse and develop resistance to chemotherapy14.
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PMC11680562
PXFCu6 gel had the more potent inhibition at 52.05 ± 1.37 mm against Escherichia coli growth.
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PMC8777939
Etravirine (T2551), paclitaxel (T1912), and wortmannin (T6283) were purchased from TargetMol (Boston, MA, USA).
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PMC8481254
2A Representative images of IHC staining of YAP, OGT, O-GlcNAc, SLC5A3, and Nudt9 in liver cancer and peritumoral tissues.
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PMC10976516
Slower replicating OVs in specific CCs can elongate the eclipse phase significantly but might also produce a lower number of virions.
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PMC9429973
The conditioning regimen consisted of fludarabine (150 mg/m), busulfan (6.4 mg/kg), and total body irradiation (TBI, 3Gy).
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PMC6835428
This is thought to guarantee a homogenous distribution of the aerosolized particles containing the drug in the peritoneal cavity .
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PMC7189327
Although BCC recurrence was extremely frequent due to local tissue destruction, it rarely metastasizes or leads to death .
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