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OTAR3088
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PMC9429973
The elongation index (EImax), that depends mostly of the cytoskeleton mechanics 2.
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PMC11768927
Wollmann et al. examined VSV-rp30’s ability to infect and kill 19 primary human melanoma samples.
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PMC11476264
To explore the role of FBXO11 in the development, progression, and prognosis of cancer, we investigated its expression in normal tissues and tumors in the TCGA and GETx databases (http://gepia.cancer-pku.cn) and found that FBXO11 was highly expressed in a variety of normal tissue compared to tumors, including BRCA, COAD, LUAD, and READ (Figure 1D).
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PMC4659567
Similarly, the additional peaks of the [Ru2(η -p-cym)2(OH)] (488.1 m/z), [Ru2(η -p-cym)2(OCH3)] (503.0 m/z), [Ru2(η -p-cym)2(OCH3)(O)] (518.9 m/z), [Ru2(η -p-cym)2(OCH3)3] (565.0 m/z) and (322.8 m/z) species were detected in the fresh 10% MeOH/H2O solution of 8 with no change after 24 and 48 h. The obtained results showed that additionally to the peaks detected in the mass spectra of MeOH solution of 2 or 8, several new peaks were found after the addition of water (S6 Fig).
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PMC11267830
i Western blot analysis of EZH2 and THOC1 after indisulam treatment.
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PMC11718109
All antibodies used in this study are listed in Supplementary Table 1.
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PMC11799620
The ability of OFAE extract to inhibit protein glycation was evaluated using a glycation system.
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PMC3164356
For each of the N50 scaffolds, a vector was used to represent the read alignments in the 22 preparations.
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PMC9739791
Thus, the Pt(IV) prodrug 30 was established as a light-activated Pt(IV) prodrug.
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PMC9019892
The combination of the pan‐FGFR inhibitors BGJ398 and imatinib repressed ERK rebound and enhanced the antitumour activity of imatinib in GISTs.
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PMC11391695
Human HCC cell lines and LO2, a normal liver cell line, were supplied for cell culture by the Cell Bank of the Chinese Academy of Sciences (Shanghai, China).
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PMC9429973
Results were considered statistically significant when P values were less than 0.05 Results: The most significant factors adversely affected overall survival are refractory anemia (p. value 0.006), fibrotic stage of the disease (p. 0.030), higher risk group according to DIPSS scoring system (p.0.03), unfavorable karyotype (p.0.02) and eventually AML transformation (P.0.00).
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PMC11754432
Individual biological replicates represented by different symbol sets, line is mean, dotted line represents normalisation to siControl at 1.
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PMC11216402
We measured the similarity of chromatin accessibility by correlation of gkm-SVM weight vectors trained on distal enhancers of each sample.
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PMC10968586
These effects were dependent on OLE-mediated ROS accumulation and reduction in CAT and SOD2 protein levels .
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PMC5034105
We systematically characterized the differential cell line susceptibility of 18 human and 15 nonhuman cell lines to two ZIKV isolates (human and primate) and dengue virus type 2 (DENV-2).
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PMC11190538
C-PC has a medium molecular weight (82.992 kDa).
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PMC9429973
Musculoskeletal and connective tissue disorders (any grade) were experienced by 39% of pts (n=33).
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PMC11476264
FBXO11 interacts with ZEB1, a core inducer of EMT.
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PMC11718817
Here, spheroid size and NK cell infiltration were assessed.
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PMC10747160
The 96-well plate was returned to the 37 °C incubator for an additional 36 to 48 h. After 36–48 h, the 96-well plate was retrieved from the humidified incubator, and luminescence activity was measured using a ClarioStar Plus microplate reader as described for direct infectivity assays in Section 2.7 and Section 2.8 above.
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PMC11781181
RNA sequencing (RNA-Seq) and gene expression analyses were performed by BioNovoGene (Suzhou, China).
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PMC11095939
not significant by Student’s t-test. (
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PMC9964654
After disassembly of the loaded micelles, the supernatants were analyzed by HPLC and the results were compared to those of the gold complexes before encapsulation (Figure 4).
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PMC11486946
Thus, the hit compounds, which were selected using EGFR-expressing CHO-K1 cells, were confirmed to robustly exert inhibitory effects on the EGFR-dependent cell viability by inducing the internalization and degradation of EGFR in various cell types including A431, EGFR-transfected Ba/F3, and Hela cells, albeit to varying degrees.
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PMC11406030
Subsequently, the membranes were washed with TBST 3× for 10 min for 30 min total.
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PMC11629461
Neither SAPLC alone nor light irradiation alone without preincubation with SALPC had any effect on baseline calcium concentration in NOX5‐CHO‐K1 cells (Figure 3).
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PMC11806106
The larger peptide agonists DAMGO and Met-enkephalin, as well as the smaller fentanyl, were characterized by a fast on-rate with approximately 10M*min (Fig. 4F), which is comparable to kinetics calculated for other GPCRs like the α2A adrenoceptor or for prostaglandin receptors.
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PMC11541241
This further indicates the relevance of the TORC1 signalling with pathogenicity in a fungal pathogen.
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PMC7185206
ADAM17 expression correlated inversely with PD-L1 protein-to-mRNA ratios (p < .0001).
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PMC9118379
PIPI: peptide tolerance = 10 ppm, fragment ion tolerance = 0.01 Da, PTM mass tolerance = ±500 Da, fixed modification = carbamidomethylation (+57), missed cleavages = 2, protease = trypsin, minimum peptide length = 7, maximum peptide length = 50, q-value = 0.01.
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PMC11628904
N = 21 control and 18 isotonic treated larvae per condition. (
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PMC11301242
Despite being included in some broader, pan-cancer studies in recent years, the diversity of diseases and sample sizes in hematological cancer research remain relatively limited .
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PMC11521786
In summary, we propose a protein-format vaccine candidate that uses HER3-DEC, combined with VSSP and Montanide as adjuvants, with the potential to induce an antitumor effect in patients with HER3-positive tumors.
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PMC11470999
It also activates several other signaling pathways, such as PI3K/Akt/mTOR, Wnt/β‐catenin, and Ras‐Raf‐MEK‐ERK, promoting cancer cell proliferation and survival while inhibiting apoptosis. ,
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PMC11422497
The results of the RT-qPCR assay revealed a significant upregulation of circ_SMA4 in GIST-T1 and GIST-882 cells compared to HGSMC cells (P < 0.05; Supplemental Fig. 2A).
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PMC11317131
These mutations were incorporated into pCMV2 PhiC31 wt, and pCMV2 HuOpt Bxb1 for use in genome targeting experiments with mammalian cells.
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PMC9429973
Cumulative CNS relapse risk at one-year was estimated as 12.2%, 9.5%, 4.5% for patients received IV-MTX, IT-MTX and no prophylactic treatment, respectively.
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PMC11095939
The liver samples were fixed in 4% paraformaldehyde at room temperature for 24 hr, embedded in paraffin, and stained for histological analysis.
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PMC11190538
4 Dose dependent anti-proliferative activity of C-PC against (A) HepG-2, (B) MCF-7, and (C) HCT-116 cancer cell-lines. *
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PMC11681005
This study was supported by the National Natural Science Foundation of China (82472733), the Fundamental Research Funds for the Central Universities (2042022dx0003) and the Research Fund of Zhongnan Hospital of Wuhan University (YYXKNLJS2024001 and PTPP2024001).
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PMC6267596
In addition, deregulated MYC expression depends on TPX2 over-expression to complete mitosis .
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PMC11754784
Target CEM cells were pre-stained with Hoechst.
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PMC9910796
To ascertain how the lack of pEP84R affects the core assembly at the molecular level, immunogold labeling with a set of anti-ASFV antibodies was performed on ultrathin sections of vEP84Ri-infected Vero cells in the presence or absence of IPTG.
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PMC9429973
One pt discontinued due to recurrence of their acalabrutinib-intolerance event (myalgia; same grade).
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PMC9429973
The results of ongoing Phase 1 study demonstrated clinical activity of IRAK4 inhibitor emavusertib (CA-4948) in patients with relapsed/refractory AML and high-risk MDS.
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PMC8481254
These results further suggest that CA inhibits the proliferation of liver cancer cells by inhibiting CDK19 activity and thereby decreasing the levels of YAP and O-GlcNAcylation.
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PMC11751675
Importantly, parthenolide's antiviral effects were observed only after the virus had penetrated the host cell, indicating that its action occurs post-infection rather than during the initial stages of viral entry.
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PMC11049548
The patients were enrolled at the Obstetrics and Gynecology Unit, Careggi University Hospital of Florence.
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PMC11476264
The His-tagged FBXO11 proteins or ZEB1-truncated proteins that bound to Ni-NTA beads were washed with PBS and collected at 4 °C.
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PMC11401358
Antioxidants, such as glutathione (GSH), can maintain the original function of cells by improving the cell growth of the microenvironment or directly ameliorating the oxidative stress state of cells and further boost the activity of cells for therapeutic applications .
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PMC10891340
The duck embryos used in the experiment were obtained from duck farms that did not vaccinate with DPV vaccine.
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PMC9352806
It is known that there are two types of cellular lipid degradation, namely, lipases-mediated lipolysis and lipophagy.
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PMC11544122
Ponceau S-stain shows GST and GST-CT from the binding reactions.
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PMC9784246
However, many patients suffer from chemotherapy-induced side effects .
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PMC4005030
Transforming growth factor-β1 (TGF-β1) and connective transforming growth factor (CTGF) are associated with the pathophysiology of liver fibrosis.
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PMC11015054
Furthermore, proliferation, migration, and invasion of liver cancer cells were suppressed when METTL5 was inhibited, increased cell apoptosis, and consequently hindered liver cancer progression.
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PMC11626627
After sacrificing the mice, the weights of excised tumors were measured (B-C). (
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PMC11468365
In DeepDDS , the work proposed a new method for representing drug features.
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PMC11628309
Furthermore, various models have demonstrated that alterations of VMAT2 levels lead to evident neuronal dysfunction.
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PMC11568601
C The expression of BAX protein was enhanced and BCL-2 protein was reduced by TGT treatment, as detected by western blot experiment.
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PMC11770130
qRT-PCR was performed using an Applied Biosystems QuantStudio 5 and TB Green Premix Ex Taq (Cat# RR420B, Takara).
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PMC7612475
SF3B1 and SF3B1 K-562 cells were maintained at an exponential growth phase.
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PMC6835428
The authors observed that the incubation reduced siLuc effectiveness by about 20%.
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PMC10854447
Compounds 7b (R = 4-F), 7c (R = 4-Cl), 7d (R = 4-Br), 7i (R = 3-Br), and 7h (R = 3-Cl) demonstrated good antiproliferative action with GI50 values ranging from 37 to 104 nM, being less potent than compound 7j (R = 2,4-di-Cl) indicating that the number of halogen atoms had a significant impact on the antiproliferative action of these compounds and that dihalo derivatives are more potent than mono halo substituted derivatives.
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PMC11201989
However, whether immune synapse regulators modulate ciliogenesis remains elusive.
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PMC9219615
Green fluorescing cells were an indication of depolarized mitochondria within a given sample.
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PMC10748106
DMSO (final concentration of 0.5%) was used as a vehicle and blank.
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PMC11063646
The resulting mixture was stirred for 10 min following the evaporation of acetone.
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PMC11703992
GAPDH and beta-Actin was chosen as the internal control (GAPDH-Elabscience, E-AB-40337, beta-Actin-Elabscience, E-AB-40338).Table 5The antibodies used in researchAntibodySequence or manufacturerDDIT4Huabio, HA722161MCL1Huabio, ET1606-14IL-6Huabio, R1203-2IFN-γSanying, 15365-1-APGAPDHElabscience, E-AB-40337TNF-αHuabio, R1203-1CD45ab27287 The antibodies used in research To determine the regulatory effect of DDIT4 expression on Jurkat cells, the CCK-8 assay was conducted.
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PMC11155445
Compound (162b) also showed prominent insecticidal activity against N. lugens comparable to thiamethoxam at 200 mg mL. Similarly, compound (162f) was found 56.6 and 60% active against P. interpunctella and N. lugens at 400 mg mL, respectively (Fig. 88).
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PMC11638255
Edge width is proportional to the number of ligand-receptor interactions between cell types.
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PMC11607638
Both sulfakinin 1 [SK1—FDDY(SO3H)GHMRF] and sulfakinin 2 [SK2—GGEGEQFDDY(SO3H)GHMRF] were used for in vivo injection.
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PMC10607604
These results suggest that PTPN13 might be a predictive marker of response to platinum salts in HGSOC.Epithelial ovarian cancer is the leading cause of death in women with gynecological cancers in Western countries .
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PMC11543885
Match Between Runs (MBR): Enable the Match Between Runs (MBR) function to align features across different runs.
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PMC9429973
Treatment, IGHV and Beta 2 microglobulin were not associated with T cell phenotype.
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PMC11502327
Chrysin, a natural flavonoid derived from Passiflora caerulea L., Oroxylum indicum (L.) Kurz and other plant sources, has previously been shown to have anti-tumor, anti-inflammatory and antioxidant effects.
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PMC9429973
At the time of HMA-F, pts presented with higher BM blasts (6% vs 10%, p<0.001) and lower platelet counts (63 K/µL vs 36 K/µL, p<0.001) than at diagnosis.
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PMC11506670
Unlike previously characterized NRAS mutants with no apparent effects on cell proliferation, these mutants enhanced proliferation of both HCT116 and NIH3T3 cells.
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PMC11590870
On the other hand, MOPH increased Caco-2 antioxidative activity to a greater extent by 73.45 ± 8.54% and 83.62 ± 2.92% at the doses 250 and 500 µg/mL, respectively.
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PMC11593084
Once bound, the ezrin family proteins regulate Rho GTPase activity, facilitating actin cytoskeleton reorganization, thereby promoting cell migration, invasion, and stemness .
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PMC11621493
Differential gene expression analysis between the groups was performed using the R-package DESeq2 (23), and the resulting P values were adjusted for multiple testing using the FDR approach based on the Benjamini–Hochberg method.
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PMC9429973
Given the potential association of these markers with worse outcomes, further studies are needed to determine whether they can serve as reliable biomarkers or predictive factors of the disease course.
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PMC9429973
Bone marrow examination was performed in 8 patients (4 LO, 4 LL) and showed mild hypoplasia in 2 (LO).
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PMC8140214
Quercetinhas been investigated for its beneficial effects such as the prevention of cell death and oxidant damage (Yarahmadi et al., 2017 ▶; Zizkova et al., 2017 ▶).
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PMC9509578
Usually, nanomicelles have negative surface charge densities in neutral plasma circulations (pH 7.4) but they switch to a positive charge in an acidic tumor environment (pH 6.5–6.7).
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PMC11754432
Subsequently cells were washed twice with PBS and imaged immediately.
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PMC11322866
SA-β-gal staining of RRM2 OE or EV cells.
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PMC6160470
Similar results were obtained by co-treatment of A2780/Adr cells with crown ethers and another chemotherapeutic – adriamycin.
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PMC11711063
Exogenous ZG16B alone blocked Bex + Carv‐mediated control of cell growth and migration, and antagonized Bex + Carv‐induced gene programs regulating cell adhesion and migration.
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PMC9429973
Glofitamab is a promising new therapy for patients with heavily pretreated and/or highly refractory DLBCL.
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PMC11697189
Immune scores were obviously different in the low-risk group and the high-risk group (Fig. 6A and C).
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PMC11607764
In cell lines and tissues derived from colon cancer, PTBP1 is overexpressed and subsequently promotes tumorigenesis via regulating apoptosis and cell cycle.
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PMC11621565
The purity and integrity of RNA were evaluated using a nano-spectrophotometer NanoDrop 2000 (ThermoScientific, USA).
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PMC9847912
Values were the maximal MOI achievable with the HIV-194UG114.1.6 and HIV-27312A virus stocks.
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PMC10812665
The above suggested general learnings seem to be confirmed by the example of BCAA.
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PMC9429973
A. Dodero, A. Guidetti, A. Lorenzoni, S. Pizzamiglio, G. Argiroffi, P. Verderio, A. Chiappella, F. Bagnoli, C. Carniti, M. Pennisi, A. Alessi, P. Corradini Hematology; Nuclear Medicine; Unit of Bioinformatics and Biostatistics, Fondazione IRCCS Istituto Nazionale dei Tumori; Hematology, Policlinico di Milano, Ospedale Maggiore Ca’ Granda, Milano, Italy Background: Autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is an effective therapy for 40% of patients (pts) with relapsed/refractory (R/R) LBCL.
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PMC7136814
After viability evaluation, cells were stained for flow cytometry analysis.
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PMC9429973
Efficacy assessments will include objective response rate, duration of response, clinical benefit rate, and progression-free survival.
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PMC9429973
Results: In the CRISPR screen, we observed that many of the gene knockouts led to cell depletion.
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