OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC6450504	Immunofluorescent detection of liposomal PTX-mediated?	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunofluorescent", "detection", "of", "liposomal", "PTX-mediated", "?" ] } ]
PMC9739791	The studies of BODI-Pt 17 binding with calf thymus DNA (ct-DNA) demonstrated that without irradiation, the level of DNA platination is very low (5.9% of Pt bound to ct-DNA), while after 30 min of irradiation, 30% of the platinum was bound to the ct-DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711063	Furthermore, cell populations shifted toward the S and G2/M cell cycle phases upon ZG16B stimulation (Figure S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "cell", ...
PMC11706491	A 2× digital zoom was used to reach Nyquist sampling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "2", "×", "digital", "zoom", "was", "used", "to", "reach", "Nyquist", "samp...
PMC11371747	Means ± SEM from three separate experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Means", "±", "SEM", "from", "three", "separate", "experiments", "." ] } ]
PMC8633974	This led to detectable excision of ∼2.5 kb of viral DNA and to the nearly complete abolition of viral release.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "led", "to", "d...
PMC3915447	As shown in Figure 4, CCRF CEM cells, in control group, displayed normal and healthy shape, demonstrated by the clear skeletons (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10907726	They were stored in a refrigerator (Siemens AG, Germany) at −20 °C away from light.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "were", "stored", "in", ...
PMC9429973	PC changes following both infection and vaccination were short-lived and generally recovered within 1 month.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PC", "changes", "following", "both", "infection", "and", "v...
PMC11730305	To address this problem, coating and conjugating them to non-metallic ligands has been proposed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "address", "this", "problem", ",", "coating", "and", ...
PMC11742231	For example, on the GDSC dataset, MGATAF achieved a 5.12% improvement in the Pearson correlation coefficient (PCC), reaching 0.9312 with an RMSE of 0.0225.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9512971	The median viral load was 6.91 log10 copies/mL (range 3.40–9.40 log10 copies/mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "viral", "load", "was", "6.91", "log10", "copies...
PMC11551844	All medium reagents were obtained from Life Technologies Inc. The cells were suspended in a fresh medium at a density of 1 × 10 cells per mL. The assays were performed in flat-bottom 96-well plates (Corning Inc., NY).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10523483	Here, we found that H1.2 was significantly up-regulated in NSCLC tumors and associated with poor survival (Fig. 1 C–F), and H1.2 deficiency suppressed NSCLC progression in vitro and in vivo (Figs. 1 K–M and 2 C and D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8270637	Blockage of the TGF-β receptor or CaN/NFATc1 pathway recovers the cytotoxicity of H9 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Blockage", "of", "the", "TGF-β", "receptor", "or", ...
PMC11656657	For the ERMS model, the RD cell line was orthotopically inoculated in the right paw muscle of NSG mice (Fig. 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11670407	To date, the majority of studies examining the mechanisms by which OTULIN regulates cell death have focused on its impact on RIPA , RIPK1 , NF-κB and TNF signaling .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11533140	The method is shown in Scheme 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "method", "is", "shown", "in", "Scheme", "1", "." ] } ]
PMC11739504	For example, KIF17 may be targets of Kat2b.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "KIF17", "may", "be", "targets", "of", "Kat2b", "." ] } ]
PMC9856122	Docking of these compounds using AutoDock Vina demonstrated maximum binding affinity with the binding free energy of −20.79 kcal/mol and −33.35 kcal/mol against M .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6889484	We previously described the development of self-activating retroviral vectors for gene therapy using directly repeated nucleotide sequences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "previously", "described", "the", "developme...
PMC11472639	ANOVA, analysis of variance.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "ANOVA", ",", "analysis", "of", "variance", "." ] } ]
PMC9429973	Long non-coding RNAs play important roles in cancer, but functions in leukemogenesis and leukemic maintenance, as well as underlying mechanisms, remain to be elucidated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485786	During injection and measurement, mice were anesthetized with 1.5% isoflurane in oxygen (0.5 L/min).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "injection", "and", "measurement", ...
PMC8735881	The assay was performed in triplicate and repeated three times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "assay", "was", "performed", "in", "triplicate", "and", "repeated", "three", "times", ...
PMC11541241	Activated TOR signalling showed a suppression effect on the CWI pathway, which eventually resulted in impairment in appressorium function and pathogenicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activated", ...
PMC9429973	Natural immunity was preferred by 30% of the participants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Natural", "immunity", "was", "preferred", "by", "30", "%", "of", "the", "participants", "....
PMC11593084	Finally, PMab-117-mG2a was produced using Fut8-deficient ExpiCHO-S (BINDS-09) cells (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "PMab-117-mG2a", "was", ...
PMC11459296	The distribution of immune cells in the A673 Ewing sarcoma tumors largely differed from that in hematopoietic organs, with monocytes being the most prominently represented cell type.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592837	As γH2AX is actively involved in the induction of apoptosis , we utilized the capacity of the AKLIDES software to discriminate diffuse pan-nuclear γH2AX staining, indicating cell degradation, from the foci-like pattern originating from DDR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11320084	Gene expression profiling interactive analysis (GEPIA) online analysis was used to analyze TNNT1 expression in LC tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", "profiling", ...
PMC11718809	Differential expression analysis was performed with the DEGSeq, and differential circRNAs with \|log2 (Fold Change)\| ≥ 1, q-values < 0.001 were further analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9503685	CSA-131 was combined with 5% Pluronic F-127 to form CSA-131-poloxamer and stored at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CSA-131", "was", "combined", "with", "5", "%", "...
PMC8009078	2Two-dimensional representation of the selected bioactives compounds, A1, A2, A3, A4 and A5 from the M. alba considered potential anti-TMPRSS2 activity Two-dimensional representation of the selected bioactives compounds, A1, A2, A3, A4 and A5 from the M. alba considered potential anti-TMPRSS2 activity The glide XP score, ADV binding energy and Prime-MMGBSA binding energy of final molecules are given in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10297204	Thus, the high concentration of ethanol treatment induced a remarkable decrease in axon number densities and caused thinning of the myelin sheath in the sciatic nerve of mice, indicating that 99.5E had caused tissue damage in the sciatic nerve.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11371747	Both DMEM and RPMI-1640 (HF) were supplemented with 10% heat-inactivated fetal bovine serum (FBS) and 20 mM Hepes pH 7.4 including 1% penicillin/streptomycin (100, IU/mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	Melanoma is a skin cancer that originates from melanocytes, which are specialized epidermal cells responsible for melanin deposition and protection from UV rays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4355729	A missense mutation of PIK3R1 which resulted in decrease of PIK3R1 expression has also been strongly linked with colon cancers18.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "missense", "mutation", ...
PMC9429973	D-dimer normalization, defined as D-dimer level less than the upper limit of normal (0.5 µg/mL) was examined at baseline, Week 8, and the end of the study period (PEGASUS: 16 weeks [RCP] and 48 weeks [OLP], PRINCE: 26 weeks).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	King Saud bin Abdulaziz University of Health Sciences, Riyadh, Saudi Arabia Background: Heparin induced thrombocytopenia (HIT) is a pro-thrombotic complication of heparin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	Zoom view (upper) shows the time series for early stages (0–30 min) post rapamycin induction, in which connection of TPPP fragments to condensates causes deformation and wetting of synMAPs onto microtubules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6934009	Moreover, it did not exhibit any toxicity on BEAS-2B normal lung cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "it", "did", "not", "exhibit", "any", "toxicity", ...
PMC10965315	In 96‐well plates, 1.2 × 10 A2780 and NIH/3T3 cells were cultured in RPMI 1640 with FBS and kept at 37°C in 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	One patient with CLL developed symptoms consistent with a tumor flare reaction during cycle 1, and continues on cycle 5 of treatment with stable disease at 15 µg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11546117	The hMECs formed a tight barrier when 10% fetal bovine serum (FBS) was added to the medium after ±35 days of culture on polyethylene terephthalate (PET) transwell inserts with a pore size of 0.4 µm and a surface area of 0.3 cm growing as a compact monolayer (Figure 3a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: In conclusion, our results indicated that the addition of Epag to CysA is well-tolerated and is an effective treatment for patients with low to intermediate-1 risk MDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	Additionally, the mechanisms underlying the observed effects of MSCs on gene expression patterns require further elucidation, and the clinical relevance of our findings warrants validation in animal models and clinical trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10125312	In vitro PPTT data focuses mostly on the cellular response of cancer cells, but the differences in uptake shown above confirm the need to study cytotoxicity in off-target tissues, as the mechanisms triggered after contact with the nanomaterial may differ between cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	Mean myofiber cross-sectional area (CSA) determined in gastrocnemius muscle from wild type or Alx3-deficient mice stained with hematoxylin and eosin (n = 5 wild type and 4 Alx3-deficient mice).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Molecular studies using NGS revealed two different heterozygous variants in the CD36 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Molecular", "studies", "using", "NGS", "revealed", "two", "different", "het...
PMC10142392	Through this review, we hope to provide a better understanding of the potential of PCL-based multi-arm architectures as a versatile drug delivery platform and to inspire further research and development in this area.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679326	Also, HddSBL delivered by adenovirus Ad.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "HddSBL", "delivered", "by", "adenovirus", "Ad", "." ] } ]
PMC11607321	Centering on the metabolite 1-methylnicotinamide, drugs known to be EMT-related were ranked as the top drugs showing high feature importance from 1-methylnicotinamide (Fig. 4b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11244823	The supernatant, comprising the secreted antigens, was transferred to chilled 1.5mL tubes, whereas the cell pellet was lysed either in an equal volume of 2x Lämmli buffer (for Western immunoblotting) or else (for LIPS assays) in 210μL of non-denaturing lysis buffer containing a protease inhibitor (Immunoprecipitation Kit, Abcam, Cambridge, UK), and transferred to fresh, chilled 1.5mL tubes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	SUDHL8 cells showed increased canonical activity compared to U2932 cells.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "SUDHL8", "cells", "showed", "increased", "canonical", "activity", "compared", "to", ...
PMC11772585	Consistently, ATF4-overexpressing HSC-1 and A431 cells exhibited higher mitochondrial mass, as indicated using the MitoTracker dye, compared to METTL1-knockdown cells (Fig. 6H).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11739484	Furthermore, MMPs play pivotal roles in angiogenesis by releasing pro-angiogenic factors and cleaving endothelial basement membrane components, promoting the formation of new blood vessels to support tumor growth and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Extramedullary involvement was detected in 26/77 (34%) of patients (mainly lymph nodes and spleen), but none had a central nervous system involvement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519567	Fig. 5A Model for SS18-SSX condensates remodeling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5A", "Model", "for", "SS18-SSX", "condensates", "remodeling", "." ] } ]
PMC11772585	RNA was extracted and sample concentrations were determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "extracted", "and", "sample", "concentrations", "were", "determined", "." ] } ]
PMC11763111	Notably, CD38 knockdown suppresses HIF1A, a key regulator of glycolysis, through the CD38-NAD -SIRT1 pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "CD38", "knockdown", "s...
PMC10578720	Secretion of TGF-β1, IL-10, TNFα, and IL-1β in human THP-1 macrophages following exposure to different HBV titers (0, 10, 10, 10 IU/mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9587866	The canonical SMILES of ligands were exploited to predict these elements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "canonical", "SMILES", "of", "ligands", "were", "exploited", "to", "predict", "...
PMC7039683	For example, cldne is expressed in zebrafish periderm from 6 hpf to 15 hpf (www.zfin.org).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "cldne", "is", ...
PMC11451940	The intracellular Cu and Zn contents were determined using ICP-MS (ICP-MS spectrometer 7700x, Agilent) using external calibration (transition metal mix 1 for ICP, Merck).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411131	Thus, selenium supplementation was effective but not sufficient for adequate Sec incorporation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "selenium", "supplementation", "was", "effective", "but", "not"...
PMC11285179	Data with error bars are shown as mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "with", "error", "bars", "are", "shown", "as", "mean", "±", "SEM", "." ] } ]
PMC11474209	It is evident that continuous monitoring of the presence of MC-LR in water outputs is necessary to maintain the water's quality and protect public health.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11679892	Pereira et al. showed that the phenolic components of P. sidoides extract triggered apoptosis in cancer cells by regulating oxidative stress and increasing reactive oxygen species (ROS) levels .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10577955	The ethanolic extract (50 gm) was chromatographed on silica gel column (3.5 D x 25 cm L.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ethanolic", ...
PMC9325715	Table 1The calculated values derived from Freundlich and Langmuir isotherm models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "1The", "calculated", "values", "derived", "from", "Freundlich", "and", "Langmuir",...
PMC9118379	Furthermore, considering 11 types of isobaric substitutions such as isoleucine/leucine substitution and delaminated-glutamine/glutamate substitution, more than 6% of variant peptides in neXtProt can be interpreted as wild-type peptides of PE1 proteins, i.e., human proteins with experimental evidence at the protein level as classified by neXtProt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	The cells were then stained with Cy5.5-anti-CD3, FITC-anti-CD4, and PE-anti-CD8 and the flow cytometry analysis was performed to detect the content of CD4 and CD8 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4005030	3, 4, 5-trihydroxy-phenylacetic acid showed to be most potent radical scavenger generated by AAPH in liposomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3", ",", "4", ",", "5-trihydroxy-pheny...
PMC10213199	The main pathways included MAPK-related activation, proliferation, and apoptosis-related pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "main", "pathways", "included", "MAPK-related", "activation", ",", "proliferatio...
PMC11705067	We further identified differentially expressed genes related to FDX1 and DLAT in ccRCC using the LinkedOmics database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "identified", "differentially", "...
PMC9429973	R. L. Knoth, S. Gupta, K. Perkowski, H. Costantino, B. Inyart, L. Ashka, K. Clapp, A. McBride Bristol Myers Squibb, Princeton, NJ; Cerner Enviza, Malvern, PA, United States of America Background: β-thalassemia is a rare genetic blood disorder affecting approximately 1 in 100,000 people globally.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8973725	Ethical approval was obtained from the Ethics Review Committee of the First Hospital of Guangxi Medical University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ethical", "approval", "was", "obtained", "from", ...
PMC10213179	Bands intensities were calculated using Fiji software and fold change with respect to the SCR control sequence is expressed below the right image.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bands",...
PMC11768927	As a proof-of-concept, El-Sayes et al. investigated the effect of type-I IFN blockade on the efficacy of oncolytic VSV therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "proof-...
PMC11499955	This is a tremendous challenge as it involves the intravenous (i.v.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "a", "tremendous", "challenge", "as", "it", "involves", ...
PMC11093197	Then, cells were blocked with 5% BSA at RT for 1 h and incubated with primary antibody at 4°C overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10932641	Therefore, finding new diagnostic and therapeutic targets for RCC is of considerable importance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "finding", "new", "diagnostic", "and", "therapeutic",...
PMC10728200	The cells were treated with IM at 0, 25, 50, and 100 nM and 0, 100, 200, and 400 nM for 24 h, and subjected to Western blot analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11047729	Rg1 has a hepatoprotective effect, promotes cerebral angiogenesis and lymphatic drainage, improves chronic inflammatory arthritis, and prevents PTSD-like behaviors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rg1", "has",...
PMC6450504	Error bars represent the standard deviation of three independent sample measurements. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "represent", "the", "standard", "deviation", "of", "three", "ind...
PMC9712534	a,b) Representative images of FRAP analysis of EGFP-TOP2B T65I and Y66F in the presence of ICRF-187.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", ",", "b", ")", "Represe...
PMC5839394	The focused proteins were then separated on 9–16% linear gradient polyacrylamide gels (SDS-PAGE) using a DALT six (GE Healthcare) apparatus with a constant current of 40 mA/gel at 10°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10218459	For data analysis and visualization, GraphPad Prism Version 9.1.2 (GraphPad Software Inc., La Jolla, CA, USA) was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11319300	This indicates that the MYEOV-3′-putative-enhancer element might have predated the development of an ORF in this region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "indicates", "that", "the", "MYEOV-3′-puta...
PMC11742290	LGR5 is associated with enhanced proliferation in many cancers including brain, breast, bone, cervical, colorectal, gastric, hepatic, and lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Seven (41.5%) patients were under 50 years of age, 10 (58.8%) patients were over 50 years, and 6 of them were over 60 years of age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10154097	YY1 participates in a variety of cancers as a transcription factor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "YY1", "participates", "in", "a", "variety", "of", "cancers", "as", "a", "transcriptio...
PMC11650848	DNA was assessed for quality control by agarose gel electrophoresis and using the Nanodrop spectrophotometer to assess purity and yield (Labtech International, Ringmer, UK); 500 ng of genomic DNA from cell pellets was bisulfite converted in house using the EZ DNA Methylation Kit (Zymo Research, California, USA) when used for pyrosequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: We used a combination of index sorting and single cell genotyping to characterize the somatic mutations of individual stem- and progenitor cells and matched high-turnover circulating cells in three patients, one treatment naïve and two AZA-treated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The MAIC analysis resulted in complete summary-level balance in the weighted distributions of the prognostic factors in MANIFEST Arm 3 versus comparators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11781181	Our previous study revealed that miR-375-3p promoted keratinocyte apoptosis by repressing XIAP in patients with SJS/TEN 19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "previous", "study", "revea...
PMC10813895	Additionally, refining the ELF5 clock as a breast-specific biological age predictor requires validation with clinically available samples, such as RPFNA, to ensure practicality and accuracy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10975211	Due to their small size, precise chemical structure, and stability, peptides utilized as ligands offer significant benefits in cellular targeting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", ...
PMC10547921	Roger D. Kornberg's team analyzed the crystal structure of RNA polymerase II-α-amanitin and found that the position of the inhibitor is adjacent to the Bridge Helix and the Trigger Loo is predominantly in a stable conformation away from the addition site (Fig. 14B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6450504

Immunofluorescent detection of liposomal PTX-mediated?

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunofluorescent", "detection", "of", "liposomal", "PTX-mediated", "?" ] } ]

PMC9739791

The studies of BODI-Pt 17 binding with calf thymus DNA (ct-DNA) demonstrated that without irradiation, the level of DNA platination is very low (5.9% of Pt bound to ct-DNA), while after 30 min of irradiation, 30% of the platinum was bound to the ct-DNA.

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PMC11711063

Furthermore, cell populations shifted toward the S and G2/M cell cycle phases upon ZG16B stimulation (Figure S4).

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PMC11706491

A 2× digital zoom was used to reach Nyquist sampling.

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PMC11371747

Means ± SEM from three separate experiments.

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PMC8633974

This led to detectable excision of ∼2.5 kb of viral DNA and to the nearly complete abolition of viral release.

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PMC3915447

As shown in Figure 4, CCRF CEM cells, in control group, displayed normal and healthy shape, demonstrated by the clear skeletons (Figure 4A).

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PMC10907726

They were stored in a refrigerator (Siemens AG, Germany) at −20 °C away from light.

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PMC9429973

PC changes following both infection and vaccination were short-lived and generally recovered within 1 month.

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PMC11730305

To address this problem, coating and conjugating them to non-metallic ligands has been proposed.

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PMC11742231

For example, on the GDSC dataset, MGATAF achieved a 5.12% improvement in the Pearson correlation coefficient (PCC), reaching 0.9312 with an RMSE of 0.0225.

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PMC9512971

The median viral load was 6.91 log10 copies/mL (range 3.40–9.40 log10 copies/mL).

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PMC11551844

All medium reagents were obtained from Life Technologies Inc. The cells were suspended in a fresh medium at a density of 1 × 10 cells per mL. The assays were performed in flat-bottom 96-well plates (Corning Inc., NY).

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PMC10523483

Here, we found that H1.2 was significantly up-regulated in NSCLC tumors and associated with poor survival (Fig. 1 C–F), and H1.2 deficiency suppressed NSCLC progression in vitro and in vivo (Figs. 1 K–M and 2 C and D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8270637

Blockage of the TGF-β receptor or CaN/NFATc1 pathway recovers the cytotoxicity of H9 cells. (

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PMC11656657

For the ERMS model, the RD cell line was orthotopically inoculated in the right paw muscle of NSG mice (Fig. 5).

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PMC11670407

To date, the majority of studies examining the mechanisms by which OTULIN regulates cell death have focused on its impact on RIPA , RIPK1 , NF-κB and TNF signaling .

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PMC11533140

The method is shown in Scheme 1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "method", "is", "shown", "in", "Scheme", "1", "." ] } ]

PMC11739504

For example, KIF17 may be targets of Kat2b.

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PMC9856122

Docking of these compounds using AutoDock Vina demonstrated maximum binding affinity with the binding free energy of −20.79 kcal/mol and −33.35 kcal/mol against M .

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PMC6889484

We previously described the development of self-activating retroviral vectors for gene therapy using directly repeated nucleotide sequences.

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PMC11472639

ANOVA, analysis of variance.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "ANOVA", ",", "analysis", "of", "variance", "." ] } ]

PMC9429973

Long non-coding RNAs play important roles in cancer, but functions in leukemogenesis and leukemic maintenance, as well as underlying mechanisms, remain to be elucidated.

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PMC4485786

During injection and measurement, mice were anesthetized with 1.5% isoflurane in oxygen (0.5 L/min).

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PMC8735881

The assay was performed in triplicate and repeated three times.

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PMC11541241

Activated TOR signalling showed a suppression effect on the CWI pathway, which eventually resulted in impairment in appressorium function and pathogenicity.

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PMC9429973

Natural immunity was preferred by 30% of the participants.

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PMC11593084

Finally, PMab-117-mG2a was produced using Fut8-deficient ExpiCHO-S (BINDS-09) cells (Figure 2A).

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PMC11459296

The distribution of immune cells in the A673 Ewing sarcoma tumors largely differed from that in hematopoietic organs, with monocytes being the most prominently represented cell type.

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PMC11592837

As γH2AX is actively involved in the induction of apoptosis , we utilized the capacity of the AKLIDES software to discriminate diffuse pan-nuclear γH2AX staining, indicating cell degradation, from the foci-like pattern originating from DDR.

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PMC11320084

Gene expression profiling interactive analysis (GEPIA) online analysis was used to analyze TNNT1 expression in LC tissues.

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PMC11718809

Differential expression analysis was performed with the DEGSeq, and differential circRNAs with |log2 (Fold Change)| ≥ 1, q-values < 0.001 were further analyzed.

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PMC9503685

CSA-131 was combined with 5% Pluronic F-127 to form CSA-131-poloxamer and stored at room temperature.

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PMC8009078

2Two-dimensional representation of the selected bioactives compounds, A1, A2, A3, A4 and A5 from the M. alba considered potential anti-TMPRSS2 activity Two-dimensional representation of the selected bioactives compounds, A1, A2, A3, A4 and A5 from the M. alba considered potential anti-TMPRSS2 activity The glide XP score, ADV binding energy and Prime-MMGBSA binding energy of final molecules are given in Table 1.

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PMC10297204

Thus, the high concentration of ethanol treatment induced a remarkable decrease in axon number densities and caused thinning of the myelin sheath in the sciatic nerve of mice, indicating that 99.5E had caused tissue damage in the sciatic nerve.

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PMC11371747

Both DMEM and RPMI-1640 (HF) were supplemented with 10% heat-inactivated fetal bovine serum (FBS) and 20 mM Hepes pH 7.4 including 1% penicillin/streptomycin (100, IU/mL).

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PMC11632064

Melanoma is a skin cancer that originates from melanocytes, which are specialized epidermal cells responsible for melanin deposition and protection from UV rays.

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PMC4355729

A missense mutation of PIK3R1 which resulted in decrease of PIK3R1 expression has also been strongly linked with colon cancers18.

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PMC9429973

D-dimer normalization, defined as D-dimer level less than the upper limit of normal (0.5 µg/mL) was examined at baseline, Week 8, and the end of the study period (PEGASUS: 16 weeks [RCP] and 48 weeks [OLP], PRINCE: 26 weeks).

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PMC9429973

King Saud bin Abdulaziz University of Health Sciences, Riyadh, Saudi Arabia Background: Heparin induced thrombocytopenia (HIT) is a pro-thrombotic complication of heparin.

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PMC11342785

Zoom view (upper) shows the time series for early stages (0–30 min) post rapamycin induction, in which connection of TPPP fragments to condensates causes deformation and wetting of synMAPs onto microtubules.

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PMC6934009

Moreover, it did not exhibit any toxicity on BEAS-2B normal lung cells.

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PMC10965315

In 96‐well plates, 1.2 × 10 A2780 and NIH/3T3 cells were cultured in RPMI 1640 with FBS and kept at 37°C in 5% CO2.

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PMC9429973

One patient with CLL developed symptoms consistent with a tumor flare reaction during cycle 1, and continues on cycle 5 of treatment with stable disease at 15 µg.

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PMC11546117

The hMECs formed a tight barrier when 10% fetal bovine serum (FBS) was added to the medium after ±35 days of culture on polyethylene terephthalate (PET) transwell inserts with a pore size of 0.4 µm and a surface area of 0.3 cm growing as a compact monolayer (Figure 3a).

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PMC9429973

Summary/Conclusion: In conclusion, our results indicated that the addition of Epag to CysA is well-tolerated and is an effective treatment for patients with low to intermediate-1 risk MDS.

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PMC11519077

Additionally, the mechanisms underlying the observed effects of MSCs on gene expression patterns require further elucidation, and the clinical relevance of our findings warrants validation in animal models and clinical trials.

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PMC10125312

In vitro PPTT data focuses mostly on the cellular response of cancer cells, but the differences in uptake shown above confirm the need to study cytotoxicity in off-target tissues, as the mechanisms triggered after contact with the nanomaterial may differ between cell types.

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PMC11335267

Mean myofiber cross-sectional area (CSA) determined in gastrocnemius muscle from wild type or Alx3-deficient mice stained with hematoxylin and eosin (n = 5 wild type and 4 Alx3-deficient mice).

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PMC9429973

Molecular studies using NGS revealed two different heterozygous variants in the CD36 gene.

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PMC10142392

Through this review, we hope to provide a better understanding of the potential of PCL-based multi-arm architectures as a versatile drug delivery platform and to inspire further research and development in this area.

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PMC11679326

Also, HddSBL delivered by adenovirus Ad.

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PMC11607321

Centering on the metabolite 1-methylnicotinamide, drugs known to be EMT-related were ranked as the top drugs showing high feature importance from 1-methylnicotinamide (Fig. 4b).

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PMC11244823

The supernatant, comprising the secreted antigens, was transferred to chilled 1.5mL tubes, whereas the cell pellet was lysed either in an equal volume of 2x Lämmli buffer (for Western immunoblotting) or else (for LIPS assays) in 210μL of non-denaturing lysis buffer containing a protease inhibitor (Immunoprecipitation Kit, Abcam, Cambridge, UK), and transferred to fresh, chilled 1.5mL tubes.

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PMC9429973

SUDHL8 cells showed increased canonical activity compared to U2932 cells.

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PMC11772585

Consistently, ATF4-overexpressing HSC-1 and A431 cells exhibited higher mitochondrial mass, as indicated using the MitoTracker dye, compared to METTL1-knockdown cells (Fig. 6H).

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PMC11739484

Furthermore, MMPs play pivotal roles in angiogenesis by releasing pro-angiogenic factors and cleaving endothelial basement membrane components, promoting the formation of new blood vessels to support tumor growth and metastasis.

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PMC9429973

Extramedullary involvement was detected in 26/77 (34%) of patients (mainly lymph nodes and spleen), but none had a central nervous system involvement.

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PMC11519567

Fig. 5A Model for SS18-SSX condensates remodeling.

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PMC11772585

RNA was extracted and sample concentrations were determined.

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PMC11763111

Notably, CD38 knockdown suppresses HIF1A, a key regulator of glycolysis, through the CD38-NAD -SIRT1 pathway .

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PMC10578720

Secretion of TGF-β1, IL-10, TNFα, and IL-1β in human THP-1 macrophages following exposure to different HBV titers (0, 10, 10, 10 IU/mL).

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PMC9587866

The canonical SMILES of ligands were exploited to predict these elements.

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PMC7039683

For example, cldne is expressed in zebrafish periderm from 6 hpf to 15 hpf (www.zfin.org).

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PMC11451940

The intracellular Cu and Zn contents were determined using ICP-MS (ICP-MS spectrometer 7700x, Agilent) using external calibration (transition metal mix 1 for ICP, Merck).

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PMC11411131

Thus, selenium supplementation was effective but not sufficient for adequate Sec incorporation.

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PMC11285179

Data with error bars are shown as mean ± SEM.

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PMC11474209

It is evident that continuous monitoring of the presence of MC-LR in water outputs is necessary to maintain the water's quality and protect public health.

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PMC11679892

Pereira et al. showed that the phenolic components of P. sidoides extract triggered apoptosis in cancer cells by regulating oxidative stress and increasing reactive oxygen species (ROS) levels .

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PMC10577955

The ethanolic extract (50 gm) was chromatographed on silica gel column (3.5 D x 25 cm L.).

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PMC9325715

Table 1The calculated values derived from Freundlich and Langmuir isotherm models.

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PMC9118379

Furthermore, considering 11 types of isobaric substitutions such as isoleucine/leucine substitution and delaminated-glutamine/glutamate substitution, more than 6% of variant peptides in neXtProt can be interpreted as wild-type peptides of PE1 proteins, i.e., human proteins with experimental evidence at the protein level as classified by neXtProt.

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PMC11783017

The cells were then stained with Cy5.5-anti-CD3, FITC-anti-CD4, and PE-anti-CD8 and the flow cytometry analysis was performed to detect the content of CD4 and CD8 T cells.

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PMC4005030

3, 4, 5-trihydroxy-phenylacetic acid showed to be most potent radical scavenger generated by AAPH in liposomes.

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PMC10213199

The main pathways included MAPK-related activation, proliferation, and apoptosis-related pathways.

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PMC11705067

We further identified differentially expressed genes related to FDX1 and DLAT in ccRCC using the LinkedOmics database.

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PMC9429973

R. L. Knoth, S. Gupta, K. Perkowski, H. Costantino, B. Inyart, L. Ashka, K. Clapp, A. McBride Bristol Myers Squibb, Princeton, NJ; Cerner Enviza, Malvern, PA, United States of America Background: β-thalassemia is a rare genetic blood disorder affecting approximately 1 in 100,000 people globally.

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PMC8973725

Ethical approval was obtained from the Ethics Review Committee of the First Hospital of Guangxi Medical University.

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PMC10213179

Bands intensities were calculated using Fiji software and fold change with respect to the SCR control sequence is expressed below the right image.

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PMC11768927

As a proof-of-concept, El-Sayes et al. investigated the effect of type-I IFN blockade on the efficacy of oncolytic VSV therapy.

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PMC11499955

This is a tremendous challenge as it involves the intravenous (i.v.)

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PMC11093197

Then, cells were blocked with 5% BSA at RT for 1 h and incubated with primary antibody at 4°C overnight.

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PMC10932641

Therefore, finding new diagnostic and therapeutic targets for RCC is of considerable importance.

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PMC10728200

The cells were treated with IM at 0, 25, 50, and 100 nM and 0, 100, 200, and 400 nM for 24 h, and subjected to Western blot analysis.

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PMC11047729

Rg1 has a hepatoprotective effect, promotes cerebral angiogenesis and lymphatic drainage, improves chronic inflammatory arthritis, and prevents PTSD-like behaviors .

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PMC6450504

Error bars represent the standard deviation of three independent sample measurements. (

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PMC9712534

a,b) Representative images of FRAP analysis of EGFP-TOP2B T65I and Y66F in the presence of ICRF-187.

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PMC5839394

The focused proteins were then separated on 9–16% linear gradient polyacrylamide gels (SDS-PAGE) using a DALT six (GE Healthcare) apparatus with a constant current of 40 mA/gel at 10°C.

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PMC10218459

For data analysis and visualization, GraphPad Prism Version 9.1.2 (GraphPad Software Inc., La Jolla, CA, USA) was used.

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PMC11319300

This indicates that the MYEOV-3′-putative-enhancer element might have predated the development of an ORF in this region.

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PMC11742290

LGR5 is associated with enhanced proliferation in many cancers including brain, breast, bone, cervical, colorectal, gastric, hepatic, and lung cancer.

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PMC9429973

Seven (41.5%) patients were under 50 years of age, 10 (58.8%) patients were over 50 years, and 6 of them were over 60 years of age.

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PMC10154097

YY1 participates in a variety of cancers as a transcription factor .

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PMC11650848

DNA was assessed for quality control by agarose gel electrophoresis and using the Nanodrop spectrophotometer to assess purity and yield (Labtech International, Ringmer, UK); 500 ng of genomic DNA from cell pellets was bisulfite converted in house using the EZ DNA Methylation Kit (Zymo Research, California, USA) when used for pyrosequencing.

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PMC9429973

Methods: We used a combination of index sorting and single cell genotyping to characterize the somatic mutations of individual stem- and progenitor cells and matched high-turnover circulating cells in three patients, one treatment naïve and two AZA-treated.

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PMC9429973

Results: The MAIC analysis resulted in complete summary-level balance in the weighted distributions of the prognostic factors in MANIFEST Arm 3 versus comparators.

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PMC11781181

Our previous study revealed that miR-375-3p promoted keratinocyte apoptosis by repressing XIAP in patients with SJS/TEN 19.

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PMC10813895

Additionally, refining the ELF5 clock as a breast-specific biological age predictor requires validation with clinically available samples, such as RPFNA, to ensure practicality and accuracy.

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PMC10975211

Due to their small size, precise chemical structure, and stability, peptides utilized as ligands offer significant benefits in cellular targeting.

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PMC10547921

Roger D. Kornberg's team analyzed the crystal structure of RNA polymerase II-α-amanitin and found that the position of the inhibitor is adjacent to the Bridge Helix and the Trigger Loo is predominantly in a stable conformation away from the addition site (Fig. 14B).

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