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OTAR3088
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BioData-CellLine_annotated

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PMC10243817
Notably, consistent but opposite correlations were found between tissue edema severity and epithelial MEX3B and TGF-βR3 expression in eosinophilic CRSwNP.
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PMC11687167
Wu et al. indicated that PCSK9 expression in HCCs was significantly downregulated by the activation of the PI3K/Akt-SREBP2 signaling pathway .
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PMC11731161
NES usually has 4–5 hydrophobic residues that bind hydrophobic pockets in a hydrophobic groove of XPO1.
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PMC9429973
It is freely available at http://biomed.bas.bg/qsarmm/Tyrosine_kinase_inhibitors.
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PMC5963610
EGFR plays an important role in cancer progression.
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PMC9429973
TAFA monotherapy demonstrated promising clinical activity in a phase 2a study in pts with R/R NHL (NCT01685008), with an ORR of 29% (n/N=10/34) in pts with FL and 33% (n/N=3/9) in pts with MZL.
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PMC6163708
This nevertheless does not preclude the efficient functioning of the HH pathway, since, in view of the fact that HH is frequently activated noncanonically at the GLI factors level, the production of the ligand itself (acting by an autocrine or paracrine manner in cell lines) is dispensable.
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PMC6364197
The medium was replaced every 48 h. Das et al found that inhibition of DDR1 expression significantly enhanced chemosensitivity of breast cancer cells to genotoxic drugs (19).
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PMC7039683
This implies human periderm enhancers share this feature and supports the use of the classifier in deltaSVM analysis of disease-associated SNPs near genes expressed in periderm.
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PMC6600253
We conclude and propose that stilbene compounds may induce senescence and may potentially be used as the therapeutic or adjuvant agents for cancers with high telomerase activity.
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PMC11026382
Thawed cell pellets were lysed by sonication in 10 ml lysis buffer (50 mM Tris, 500 mM NaCl, 10 mM imidazole, pH 8.0 buffer containing 0.1 mM PMSF, 0.001 mg/ml pepstatin, 0.01 mg/ml leupeptin, 20 µg/ml DNAseI and 5 µg/mL lysozyme).
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PMC11306331
n = 8,8 cells from conditions labeled left to right, pooled from three biological replicates that all produced similar results.
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PMC9509578
Atypical regulation of NF-κB has been shown to be crucial for the development of MDR.
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PMC9776316
The rescued expression of XRCC4 significantly boosted the decreased cell viability caused by the combination of cisplatin treatment and XRCC4 knockdown (Figure 4b).
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PMC11633763
Aerobic glycolysis is widely recognised as a characteristic metabolic pathway in osteosarcoma.
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PMC11290772
Calculation of lysis ratio of organoid after treatment with ROBO1-NK cells.
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PMC11612626
Multiple myeloma cells were then treated with compound A and lysates prepared.
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PMC11588008
MSC cells were plated in 24 transwell chambers.
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PMC10174970
In pan-pathway analysis, the cell lines showing the highest genetic correlation to patient tumors were Panc 03.27 for PAAD cell lines from a primary lesion site and CFPAC-1 for PAAD cell lines from a metastatic lesion site.
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PMC11365427
The lack of nutrition was offset by increased corn starch levels due to phenylalanine deficiency.
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PMC8658661
Sustainable and reliable methods for preventing and treating liver cancer require fundamental research on its molecular mechanisms.
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PMC9429973
We divided patients into those who received either single-agent Len maintenance (Len-only) or Len-based combinations (Len-combo).
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PMC11772449
After 48 hours of culture, CCK-8 was used to detect cell survival and determine its proliferation activity. (
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PMC11306019
Furthermore, crosslinking galloyl groups in cori-triGG and telli-PGG impaired their antagonistic potency, as compared to 1,3,6-triGG and PGG, respectively.
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PMC11502443
For pCREB, GIP(1-30)NH2 was ∼11-fold more efficacious compared to GIP(1-42); however, this did not reach significance (Supplementary Table S2).
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PMC11401350
At sacrifice, single cell suspensions were prepared from the lymphoma biopsies (spleen, LNs) for further experimentation and analysis.
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PMC10048572
According to our model, spontaneous aberrations in the genome of cells of non-tumor origin occur in less than 1 of 100 cultured cells.
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PMC10253553
RAPTOR is a protein that is present in mTORC1 but not mTORC2 .
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PMC11740907
This, in turn, contributes to the advancement of nanomedicine therapies that are more effective.
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PMC11319300
The analysis of 3D genome datasets revealed chromatin interactions between a MYEOV-3′-putative enhancer and the proto-oncogene CCND1.
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PMC8711270
Comparison of various LV production methods.
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PMC5673060
An association network of proteins from the ‘insulin signalling’ and ‘transcription’ clusters were analysed through the STRING application.
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PMC11746948
Statistical analysis: two-way ANOVA with Tukey’s test for (c, j); one-way ANOVA with Tukey’s test for (g, h, l).
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PMC10114490
Total RNA was isolated using MicroElute Total RNA Kit (Omega Bio-Tek R6831).
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PMC11320834
The obtained data are expressed as the mean ± SD of at least three independent experiments and in the case of IC50, as an estimated value ± SEM.
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PMC11659921
C–E) Construction of prognostic models related to angiogenesis and stemness in the TCGA‐OV dataset. (
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PMC9504875
Expression of the RIG-I two CARDs alone induces K63-linked ubiquitination without any stimulation .
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PMC10218459
The results of the isolated application of CPP in the current study confirmed these effects.
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PMC6442998
These clusters could be linked to the occurrence of relapse or progression after imatinib treatment.
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PMC10936243
But I think in terms of management and cost, to wash it that often and to control with the bio-security, I think that will lead to higher cost” [D063]. “
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PMC9429973
Methods: Pts with MM and 1–3 prior lines of therapy (including a LEN-containing regimen) who had been randomized 1:1 to PVd or Vd were assessed for frailty.
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PMC7022782
In Figure 7B, it is possible to appreciate superficial caveolae constituted by pit-coated invaginations of the plasma membrane on their inner side (arrow).
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PMC9429973
Neutropenia (65%; grade 3/4: 57%), anemia (50%; grade 3/4: 35%), thrombocytopenia (38%; grade 3/4: 21%), and lymphopenia (34%; grade 3/4: 32%) were the most common hematologic AEs.
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PMC10587429
Stain with antibodies in the dark at room temperature for 1/2 hour ( Table 2 ).
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PMC11718109
Quantification of the size of these vesicles is shown in dot plot (I) and frequency histogram (J).
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PMC11261875
GIST: gastrointestinal stromal tumor; GLUT: glucose transporter; HK: hexokinase; LDH: lactate dehydrogenase; MCT: monocarboxylate transporters; PK: pyruvate kinase F-Fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is one of the most commonly used functional imaging modalities in clinical practice.
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PMC11745823
Cells engage in several physiological and pathological processes by precisely modulating particular coding gene or non‐coding RNA expression via oxygen receptors and signal transduction pathways .
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PMC11754291
Following a 2-h incubation at 37°C, 100 μL from each well treated with AlamarBlue was transferred to a corresponding well in a 96-well plate for analysis via a plate reader.
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PMC10745221
The inhibitors are abbreviated with their letters at the top of each lane.
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PMC11467800
Signs of extravasation were examined on the same larvae for three consecutive days.
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PMC11772585
ATF4 overexpression promoted METTL1-deficient HSC-1 xenograft tumor growth (A) and reduced tumor weight (B).
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PMC11487720
Without cold shock, UV only induced bubbling at all temperatures, whereas the efficiency of bubbling at 37 °C was reduced by greater than 50%.
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PMC11741577
On day 3, closure in the FSL-1-HMC-1 CM- and FSL-1-treated groups was approximately 3- and 2-fold higher than that in the serum-free IMDM-treated group, respectively.
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PMC4277423
At the 6 days post-infection the ratio of CCR5 and CCR5 cells became 4∶6 (upper/right panel) and at the 18 days post-infection the ratio became 9∶1 (lower/right panel).
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PMC9429973
Since 2019, native L-asparaginase is no longer available in the Canada such that pegylated (PEG)-ASNase has gradually replaced native e.coli ASNase (L-ASNase) as part of the DFCI protocol at our centre.
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PMC9429973
This patient had an ommaya reservoir implanted to receive I-VEN AUTO1, following which the patient developed grade 2 CRS for 5 days, without overt ICANS.
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PMC9952933
The cell viability of the HOB is less impaired after 60 s CAP treatment than that of the two malignant bone cancer cell lines after 5 s of treatment.
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PMC9429973
In the current study, this treatment showed robust activity against adult (r/r) B-ALL without >Grade 2 toxicity.
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PMC11629461
NOX5, same as the catalytic subunit of all other NOX isozymes, coordinately binds NADPH, FAD, and two heme molecules, the absorption spectra of these molecules when dissolved free in solvent are shown in Figure S1.
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PMC9878562
Cells were centrifuged at 350g for 3 minutes, re-suspended at 10 cells mL in plain RPMI and incubated for 30 minutes at 37°C.
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PMC11774747
However, the scalability of the CAR-VST manufacturing process remain a significant challenge, as current clinical trials have only been conducted with small cohorts of patients.
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PMC11366496
The above literature shows that RNF122 has an essential function in biological processes.
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PMC11591038
This finding adds one more mechanism for the beneficial effect of HIF-1α expression and neuroglobin with potential therapeutic values for AD.
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PMC11770199
Human MSCs were transfected with plasmids of PCDH-GFP and PCDH-GFP-p14 and mixed with cancer cells at 8 h after transfection at the ratios of 1:5, 1:12.5, and 1:25.
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PMC11484188
no. 3738; 1:1,000; Cell Signaling Technology, Inc.).
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PMC9429973
Worth mentioning is that in the group of patients with response two patients had ibrutinib monotherapy and one had rituximab-ibrutinib.
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PMC4277423
The lentiviral vector expressing Cas9-HA-NLS fusion protein was co-transduced into the HIV-1-susceptible cell line TZM.bl with the vectors expressing sgRNA CR1, CR2, CR3 or GF1 as described .
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PMC11583010
Free dye was removed with Zeba spin desalting column.
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PMC10387886
We observed a near complete disappearance of E-cadherin expression upon TGFβ1 administration by immunofluorescence analysis (Figure 1A).
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PMC11422497
Differential expression profiles of circRNAs in GISTs were successfully established.
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PMC3888431
By applying this pipeline to CHO cell RNA-seq data from different sequencing technologies, we could improve and extend the publicly available CHO cell transcriptome.
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PMC9429973
Training of the physicians, nurses, and pharmacists was mandatory before delivering the treatment.
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PMC11583010
A chemotherapy control group (red diamonds) was treated with carboplatin (40 mg/kg, QW × 4).
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PMC11676674
As a result, all three selected concentrations, 50, 100 and 200 μg/mL, of C. monspeliensis leaf extracts were chosen for MN evaluation.
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PMC11711127
The delicate balance between tolerance and inflammation remains a focal point, with Tregs and tolDCs playing critical roles in establishing Ag-specific tolerance.
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PMC11534377
The medium was removed, and cells were incubated with 150μl of thyazolyl blue tetrazolium bromide (1 mg/ml, Sigma, USA) for 1 hour at 37°C.
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PMC8996378
Four jatrophane diterpenes were isolated from Euphorbia pubescens (compounds 23–26, Table 1) (Valente et al., 2004).
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PMC11786767
Expansion was determined to be 3.5-fold.
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PMC9429973
The most common 3-4 level AEs with RI-CHOP were neutrophil count decreased(14/31), thrombocytopenia(5/31) and typically occurred within the 4~6 cycles.
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PMC10094992
To exclude a direct effect of NR6 on neutrophils, we assayed ALDH1A3 expression by Western blot analysis and performed a cell viability assay upon NR6 treatment.
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PMC10748106
As an initial step, Euphrasin, Campsinol, Artselaenin A, and Artselaenin B were compared in terms of their structure, activity, and molecular descriptors against Genipin.
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PMC11185260
Mice received total 6 injections of scL-SMARCB1 (30μg/injection, twice weekly for 3 weeks) and/or 3 fractions of radiation (5Gy, weekly for 3 weeks).
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PMC11641532
Tumor volume was calculated using the formula: (length × width)/2, where the length was defined as the longest dimension and the width was the perpendicular measurement.
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PMC11026382
We selected 10-formyl THF with three glutamates as a representative growth-linked reduced folate for parameterizing the model given it’s clear relationship to growth and proximity to purine biosynthesis.
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PMC11286266
Additionally, guides targeting IGFR1 and CXXC1 were also dismissed as likely affecting ER proteostasis indirectly via cellular growth (Pfaffenbach et al., 2012).
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PMC11285179
The mean fluorescence intensity of CCL28 was significantly upregulated when bevacizumab was used compared to the control group (Fig. 6C, lower panel), consistent with the results we found in the clinical samples.
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PMC11676674
However, more studies need to be conducted to better understand the mechanisms underlying the protective effect of the C. monspeliensis plant and its main active compounds on other genotoxic agents.
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PMC9318744
Our data on authentic virus infection, pseudotyped virus infection, and antiviral assays highlight the potential of the ACE2plusC3 cell model for studying emerging SARS-CoV-2 variants and antiviral drug screens.
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PMC8992508
None compounds showed significant activity toward MRP1 while compounds with one or more methoxy groups at the phenyl ring showed activity toward P-gp as compounds 54 (IC50 = 4.78 M) and 55 (IC50 = 5.43 M).
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PMC11502066
However, the pharmacokinetic parameters of flavonoids can be somewhat different between healthy people and cancer patients due to a number of metabolic changes accompanied by malignant processes .
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PMC11766332
We considered clinical studies reporting (1) patients with ASD diagnosed by established diagnostic criteria and (2) miRNA expression changes that were significantly different in ASD patients compared to control subjects.
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PMC11703896
In contrast, higher RMSF values with ROS1 and FGFR receptors suggest increased fluctuation, which may imply weaker or less stable binding under physiological conditions.
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PMC11040965
A Representative western blots of PI3K/AKT pathway components in conditions of CD28 stimulation or blocking.
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PMC11760643
To confirm the functionality of the anti‐P2X7 mAb, the ability of this mAb to block ATP‐induced Ca responses in HEK‐P2X7 cells was examined.
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PMC11551844
Nocodazole (660 μM) was dissolved in DMSO and stored at −20 °C.
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PMC11546117
However, the addition of 10% FBS to the culture medium resulted in the formation of a tight barrier after ±35 days.
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PMC8992508
On these bases, identification of inhibitors against ABC transporters, such as P-glycoprotein (P-gp/MDR1/ABCB1, or multidrug resistance-associated proteins (MRPs/ABCCs), and breast cancer protein (BCRP/ABCG2) has emerged as critical goal because their inhibition may improve both chemotherapeutic response and patient outcomes.
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PMC11575040
After NGS, we collected more than 89 million clean reads from all libraries (Figure S1A).
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PMC9966931
Figure 5 shows the chromatograms obtained via GC-MS of the enzymatic reactions when benzoic acid was used as the carboxylic acid and thymol, carvacrol, and eugenol were used as phenol compounds, obtaining hybrids (1), (2), and (3), respectively.
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PMC11791203
Sl.
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