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OTAR3088
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BioData-CellLine_annotated

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PMC11637820
Several studies have previously documented the safety of CAP exposure in human cells and tissues .
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PMC9812014
Other alkaloids, such as pericalline, Pervine along with periformyline and leucristine have also been found to have anti-PV properties .
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PMC11525028
Overall, these results indicate that NAT10 promotes osteosarcoma growth and metastasis via the ATF4/ASNS/Asn axis.
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PMC11673128
Cancer cell lines were collected after centrifugation (i.e., suspended cells: K299, SUP-M2, AS4) or 2 mM EDTA detachment (i.e., adherent cells: H3122, CLB-Ga) and subsequently stained with carboxyfluorescein succinimidyl ester (CFSE, Thermo Fisher).
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PMC11792740
It can be achieved by combining immune checkpoint inhibitors, CAR-T-cell therapy, TCR engineering, tumor vaccines, immunometabolic modulation, TME improvement, and research on drug resistance mechanisms.
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PMC11672617
The quantification of cytochrome c release from mitochondria in apoptotic cells was employed to detect the mitochondrial pathway of apoptosis in cells using flow cytometry.
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PMC9429973
The median duration of MRD negativity was not reached.
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PMC11190538
Nanoliposomes enhance the efficacy of bioactive pharmaceuticals by mitigating unfavorable interactions between bioactive molecules and enhancing their solubility, bioavailability, and stability both in vitro and in vivo .
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PMC9429973
Several BCL2L12 circRNAs in NB-4 and HL-60 cells exhibited complete intron retention; additionally, a novel exon was present at a remarkable frequency in NB-4 cells.
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PMC9621239
The luciferase activity was significantly higher in the 293 T cells expressing HBx-TM than that in the 293 T cells expressing HBx-WT (Figure 3F).
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PMC8041314
2D representation of multitarget ABCB1, ABCC1, and ABCG2 inhibitors discovered in this work: the quinoline and 1,2,4-oxadiazole derivative 15, the quinoline and 1,3,4-thiadiazole derivative 18, the quinazoline and 1,2,4-oxadiazole derivative 21, the quinoline and thieno[3,2-c]pyridine derivative 22, as well as the quinoline and 1,2,4-oxadiazole derivative 26.
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PMC11676169
Further, BCAT1 depletion seems to promote an ineffective DDR following etoposide treatment.
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PMC8143558
Thus, they can be used to bath, wash hands, utensils, and surfaces, or even shampoo hair, just like any other soap.
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PMC10154097
P < 0.05 refers to a difference.
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PMC11593713
Research has also demonstrated the involvement of oxidative pathways in the start, maintenance, and advancement of carcinogenesis .
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PMC10890055
However, some of its components (e.g., ferrous sulphate, HEPES) may have negative effects on certain cell types .
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PMC10940855
Primary multiple myeloma samples were obtained from BM aspirates of patients with multiple myeloma from the UCLA Ronald Reagan Medical Center under a UCLA Institutional Review Board (IRB)–approved protocol (principal investigator: Joshua Sasine, protocol no. 15–000062) after written informed consent was obtained from each patient.
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PMC10048572
This robust research tool provides information on a variety of changes in the genome, including chromosome aberrations and small deletions and insertions of several nucleotides.
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PMC6835428
It is biodegradable and, in the field of drug delivery, it is typically used to tune the physical, chemical, and mechanical properties of different materials when co-polymerized with polymers such as PEG.
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PMC10454535
As concentrations of each compound increased from 0 μM to 50 μM, the viability of treated RPMI 8226 cells decreased, with all the concentrations being significantly different compared to the vehicle control.
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PMC10582049
Expression of canonical marker genes of CAFs (FAPACTA2; ADH1B, CTHRC1FAP), pericytes (RGS5TINAGL), and smooth muscle cells (DESMYH11) in stromal cell subpopulations.
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PMC9351137
The anti-Ser10 H3P was used to test the decreased levels of phosphorylated H3 due to the inhibition of Aurora B kinase activity).
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PMC9429973
Methods: Patients diagnosed with CLL/SLL between 1/1/2010 – 6/30/2020 that were at least 18 years old and initiated VO in the 1L or VR in RR were identified in Optum Clinformatics database.
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PMC11568601
Under natural conditions, the expression level of endogenous CHOP is generally very low.
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PMC11576293
A significant correlation exists between RMo and slope (b) with r ≈ −0.9985 in MeOH/H2O, which suggests a similar chromatographic retention mechanism for this congeneric series of compounds.
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PMC7582629
The intensities of these two bands (at 752 and 784 cm) are reversed in the red spectrum.
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PMC9429973
Further, there is no consensus about the levels of D-d that could predict new TE.
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PMC11536589
These results indicated that the KRAS inhibitor MRTX1133 treatment could induce ferroptosis in PDAC.
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PMC11730311
Plasma exposure for all compounds is presented in Fig. 4a and plasma exposure normalized to peak plasma concentrations is presented in Fig. 4b.
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PMC11680578
To analyze them using flow cytometry, 1 ml of a 50 µg/ml solution of propidium iodide (PI) in PBS from Invitrogen kit was added to the preserved cells Subsequently, the samples were incubated for 30 min at 4ºC before being examined using a Ctyoflex LS (Beckman Coulter flow cytometry) as per the guidelines provided by the cell cycle kit BD DNA QC Particles, BD Biosciences (USA).
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PMC11696659
In conclusion, the preliminary results of this study suggest that telomere length measurements in peripheral lymphocytes could be useful as diagnostic biomarkers during lung cancer screening in high-risk patients.
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PMC11087055
The above data showed that a deformed midline structure allowed the polonaise movements to occur while the position of the LR rotations in the polonaise movements was affected (Figure 1 and Figure 1—figure supplement 1).
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PMC9856122
All BBI alkaloids included in the study were found to be effective and showed IC50 values in the range of 14.8–43.2 µg/mL. Results confirmed that homoarmoline, isotetrandrine, berbamine, thalrugosine, and obamegine demonstrated anti-HSV-1 and HSV-2 potential with IC50 in the range of 16.3 to 24.9 µg/mL .
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PMC11700165
Whole cell lysates of COS-7 cells expressing IS = ITK-SYK, BS = BTK-SYK, and TS = TEL-SYK along with SLP-76.
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PMC9429973
The total apoptosis rate increased significantly in the Ven+DZNeP group(Fig.1C).
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PMC10578720
CS/PDHC hyperacetylation markedly inhibited their enzymatic activities, associated with impaired TCA cycle and M2-like polarization of macrophages.
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PMC11696576
Compounds 15a–j (1.00 mmol) were treated with a solution of 2 N HCl in MeOH (10 mL).
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PMC11472639
This study was primarily focussed on patients with SMM, as this patient group is treatment-naïve yet commonly has detectable clonal cells in blood (Sanoja-Flores et al., 2018; Termini et al., 2022).
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PMC11585587
The results showed that the rates of MM.1 S cells in the G2 phase were 17.6%±1.53%, 19.67%±2.37%, 24.72%±2.61%, 37.63%±2.32%, respectively, after the effects of RA (0, 0.5, 1, 2 µM) (Fig. 2A-C).
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PMC11711063
Tumor cells were pre‐treated for 48 h with DMSO, Bex (1 μM), Carv (1 μM), Bex + Carv (1 μM each), control, or ZG16B‐enriched supernatants.
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PMC11637284
The region interacting with the p166 C-tail corresponded to the TAC60 segment E175-L198.
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PMC11248911
The percentage of LDH release was determined by dividing the LDH released into the media by the total LDH following cell lysis in the same well.
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PMC11640247
Primary antibodies used were anti-Myc (Medical & Biological Laboratories, Nagoya, Japan; Cat# M047-3, RRID: AB_591112) and anti-GFPs from Medical & Biological Laboratories (Cat# 598, RRID: AB_591819) and Nacalai Tesque (Kyoto, Japan; Cat# 04404-84, RRID: AB_10013361).
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PMC7553912
P < 0.05 compared with WT mice.
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PMC5839394
Results (Figure 2A) showed an inhibition of migratory ability both at 6 and 24 h in AgNPs-EPS treated cells.
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PMC11473843
Therefore, we took advantage of this vulnerability to dissect the specific regulatory site/s of FAK required for the maintenance of KRAS mutated cancer cells.
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PMC11337594
Data in A, B and E are shown as mean + SEM.
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PMC8992508
P-gp inhibiting activity was evaluated on K562/DOX doxorubicin resistant cells, measuring their effect on THP-adriamycin (pirarubicin) nuclear uptake.
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PMC11760643
Finally, numbers of all three MDSC subsets were significantly decreased in anti‐P2X7 mAb‐treated cells compared with isotype control mAb‐treated cells, with E‐MDSCs decreased by 33.7 ± 8.0% (p = 0.02; Figure 4V), G‐MDSCs decreased by 37.9 ± 9.3% (p = 0.03; Figure 4W), and M‐MDSCs decreased by 32.4 ± 6.5% (p = 0.04; Figure 4X).
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PMC11699042
The EwS MHH-ES-1, SK-ES-1, SK-N-MC, and TC-71 cell lines were purchased from the German Collection of Microorganism and Cell Cultures (DSMZ).
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PMC9429973
Results: Eighty-six patients from 12 centers throughout the country were included.
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PMC8345486
Cisplatin was an efficient inductor of ROS production, which accompanied apoptosis.
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PMC9429973
Eligible patients with TDT were required to have ≥8 RBCTs in any 12-month period on or after the date of the earliest qualifying beta-thalassemia claim (first RBCT date = index date) and at least 12 months of post-index continuous enrollment with medical and pharmacy benefits.
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PMC11283030
Simultaneously, it demonstrated that high p-ACLY (HR 4.265, 95 % CI = 2.770–6.566, P < 0.001), high histological grade (HR 2.152, 95 % CI = 1.573–2.943, P < 0.001), large tumor (HR 4.869, 95 % CI = 3.285–7.217, P < 0.001), advanced pathological stage (HR 2.414, 95 % CI = 1.492–3.906, P < 0.001), and metastasis (HR 9.060, CI = 5.179–15.849, P < 0.001), were all associated with a shorter CSS rate.
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PMC6461034
Immediately sonicate in three cycles, e.g., 15 s on/1 min off at maximum amplitude when using a Branson high‐intensity cuphorn sonicator.
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PMC11721064
Moreover, the transdifferentiation of p63-positive corneal epithelial progenitor cells has been inadequately examined and quantified, primarily focusing on qualitative analyses.
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PMC11474209
For enzymatic detection, immunosensors are frequently employed.
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PMC11502066
Moreover, quercetin-3-O-glucuronide could act also as a competitive antagonist for β2-AR, inhibiting the binding of [H]-NA to β2-AR in human breast adenocarcinoma cells MDA-MB-231.
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PMC11612315
Calcium increases were elicited by CAP (100 nM) in the presence of GLP-1 analogs (100 nM each), GLP-1(7–36) (b), exendin-4 (c), liraglutide (d), or exendin 9–39 (Exe 9–39) (e) (mean ± S.E.M.).
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PMC11713609
X.Y. conducted analysis and interpretation of data.
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PMC5811757
Following this 48 hr incubation period, 20µl of colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT; Sigma-Aldrich, USA) was added to each well.
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PMC11604768
In contrast, NTSR1 agonism led to the activation of promoters also activated by either the Gαs-coupled aminergic GPCRs (β2AR and D1R) or 5-HT2A (Supplementary Fig. 9E).
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PMC11585254
Raw luminescence values were corrected by background subtraction, and the area under the curve was determined for each treatment condition using GraphPad PRISM.
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PMC11126803
The scale bar represents 80 μm, 100× and 20 μm, 400×.
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PMC11021472
Immunoprecipitation of AGO2-containing RISC complexes was performed as described previously with minor modifications.
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PMC10547921
The key is to find and deal with the cause of the narrow treatment window.
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PMC11240448
Because the DPDs connect molecular features to the phenotypes, the logical next step is to predict how to control and purposefully manipulate the DPD scores, thereby engineering the cell phenotype.
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PMC9429973
Given the multiple ways a CLL population in a patient can become resistant to ongoing VEN, it seems unlikely that simply adding other drugs at relapse will be durably effective in most patients.
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PMC9429973
The blood transfusion rate was 0.99 (0.77–1.27), and most patients received hydroxyurea (78%) and supportive treatments (95%).
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PMC11720107
In rats fed fresh garlic homogenate for 30 days, cardioprotective effects were observed .
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PMC11794847
Some studies argued that HVEM were negative predictors in gastric, ovarian, and colorectal cancers [35–37].
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PMC11725127
The cellular extracts were immunoprecipitated with anti-Flag antibody followed by Western blot with indicated antibodies. (
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PMC8357004
The overexpression of HDACs represses transcription of INK4 and CIP/KIP families such as p15INK4b and p21WAF1/CIP1, which in turn, induces cancer induction.
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PMC11095939
ChIP-DNA from the liver was obtained as described above.
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PMC11470999
p < 0.05, p < 0.01, p < 0.001.Poly (ADP‐ribose) polymerase, PARP; 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide, MTT.
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PMC11419566
P-glycoprotein (P-gp) expression in lung cancer cells was also significantly reduced by PA.
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PMC10502403
Evaluation of spare respiratory capacity (SRC) is a useful method for assessing mitochondrial function in T cells.
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PMC9847912
The resultant dose-response profile for M3 was similar to the profiles obtained with HIV-1 (Fig 3B).
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PMC11435360
These high rates paired with lengthy treatment times and associated therapeutic complications give BC one of the highest lifetime treatment costs per patient compared to other malignancies .
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PMC9503669
Moreover, when inhibitor-treated cells were co-cultured with autologous CD8 T cells expanded in the presence of HIV-1 antigenic peptides, the CD8 T cells became activated and displayed CTL responses against the infected CD4 target cells .
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PMC7185206
Schematic for panels C-D. 786–0 cells expressing C-terminus PD-L1 GFP (786-0-PDL1-GFP) at 3 · 10 cells/ml were labeled with Alexafluor-647-conjugated atezolizumab (ATZ-Alexa647) and then treated as indicated prior to assay. (
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PMC9429973
The median platelet count at diagnosis was significantly higher in Group-1 (20x10/L, interquartile range: 5-44x10/L) than in Group-2 (11x10/L, interquartile range: 5-32x10/L; P=0.0096).
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PMC8481254
We also found that CA could regulate the protein expression of YAP but had little effect on the mRNA level of YAP, indicating that CA regulates YAP expression at the protein level.
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PMC11699465
Its deficiency results in a hepatic phenotype with abnormal glycosylation.
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PMC10705095
Furthermore, we examined the relationship between HBQ1 expression and clinical outcomes in patients with lung adenocarcinoma.
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PMC6267596
On the other hand, all left most (same vertical line) proteins identified only in DMSO control but absent in 8n-cells.
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PMC8750422
We used GPR87-overexpressing and GPR87-silenced lung adonocarcinoma cell lines, along with in vivo studies, to demonstrate that overexpression of GPR87 promoted invasiveness and metastasis of lung adenocarcinoma cells.
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PMC5261804
We then computed log rank p-values for survival based on whether each of the PPIs was present or absent.
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PMC3681794
Significant hypoxia-induced drug resistance in osteosarcoma cells highlights the potential importance of hypoxia as a target to reverse drug resistance in paediatric osteosarcoma.
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PMC11507371
Based on the assessed oxygen consumption rates, which showed a significant inhibition in the cellular respiration of A431 cells after 5.5 h of 60 s CAP exposure (Figure 3), not solely the external but also the internal ROS levels are likely to increase upon CAP exposure,.
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PMC11705067
This may explain the different prognostic significance of FDX1 and DLAT methylation sites in ccRCC patients.
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PMC10955424
IL-3, MCP-1, growth hormone, IL-17A, basic FGF, HGF and others were also enriched in the OC ascites (Fig. 2B).
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PMC9065483
Transcriptional expression of genes encoding immune cell-attracting cytokines CXCL9 and CXCL10 were also assessed by qPCR.
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PMC8557138
3D bioprinting constitutes the fabrication of a pre-defined matrix by the deposition of hydrogels containing either one cell type or a mixture of different cell types in the form of a thin filament, either by fused filament fabrication or fused deposition modeling.
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PMC11244823
The smaller gD1 fragments carry a smaller number of antibody epitopes but the gD1_83 fragment is most likely to pick up antibodies that can only be observed following specific exposure to EHV-1.
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PMC11788920
When dCas9 targets the NTS, RNAP and dCas9 collide in a PAM-proximal mode in which RNAP is more likely to be stalled or dislodged from the DNA, both resulting in a truncated RNA transcript.
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PMC11575040
Xiang et al. reported that the LINC00094/miR-19a-3p/CYP19A1 axis affected the degree of sensitivity to letrozole through the EMT pathway in estrogen-receptor-positive (ER-positive) breast cancer.
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PMC6312945
The supernatant was taken as the ELISA test sample.
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PMC10808409
The high EE% observed with all the formulae might be due to the hydrogen bonding between the ether oxygen of PEO part and the hydroxyl group present in FA.
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PMC8584319
Interestingly, AZD8055 regulated the 4E-BP1 mRNA pool by up-regulating the ERK1/2 and p38 pathways.
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