OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11607321	d Fisher skew test per gene across the original CRISPR-Cas9 dataset (x-axis) and the MOSA augmented dataset (y-axis).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Fisher"...
PMC11635087	Chloroplasts were visualized according to chlorophyll autofluorescence (magenta).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chloroplasts", "were", "visualized", "according", "to", "chlorophyll", "autofluorescence", "(", "magen...
PMC8348645	Test for Steroids: Lieberman Burchardt tests: We mixed 0.2 mL of sample with 0.2 mL of chloroform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Test", "for", "Steroids", ":", ...
PMC5673060	These include the LIM domain family of proteins CRIP2, LASP1, MICALL1 and PDLIM7 which have previously been shown to be localised in focal adhesion complexes and play important roles in mechanotransduction signalling , , .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11423992	This approach relies on the recognition of tumor cell surface antigens and simultaneous binding to the CD3 epsilon chain (CD3ε) within the TCR complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7841189	The results demonstrated that the expression of LTBP2 was also significantly increased in thyroid carcinoma cell lines (Fig. 1C and D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11774251	Top10 enriched GO terms categorized into biological process, cellular component, and molecular function. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Top10", "enriched", "GO", "terms", "categorized", "int...
PMC3019555	This intriguing result prompted us to examine the spatial and temporal distribution of HIF-1α mRNA after MB transfection in MCF7–GFP-tub cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "intriguing", ...
PMC8806312	Osteosarcoma (OS) is a primary malignant bone tumor with a morbidity of 4,000,000 annually in children and adolescents .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Osteosarcoma", "(", "OS", ...
PMC10968586	On the contrary, 400 μM showed a consistent cytotoxic action at all the assayed time points (24, 48, and 72 h) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9847912	IC50 values were calculated for the HIV-1 isolates using a four-parameter regression model in GraphPad Prism 6.0 as described in the Materials & methods; the regression curves are shown as dashed lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10452486	These two observations put an end to the belief of many investigators that Face-2 results solely from the dissociation of B2m from Face-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC2196094	A nearly full-length cDNA clone for the rat chymase RMCP-5 was isolated (Figs. 2 A and 5 A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "nearly", "full-length",...
PMC9000591	In general, the SE4 fraction presented the strongest antioxidant activity in both the DPPH and ABTS assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "general", ",", "the", "SE4", ...
PMC11670954	Furthermore, BA inhibited the expression of RhoA, ROCK2, and MLCK, and normalized their localization within Caco2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Furthermore", ...
PMC9429973	The estimated median overall survival (OS) of the entire cohort was eight (CI 95% 0-16.2) months and was significantly higher in patients who achieved CR compared to those who did not (16.3 months, CI 95% 0-36.2 vs. 2.6 months, CI 95% 1.47-3.7; p value=0.046, figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Primary causes of death on study included MF (n=7), lung infection (n=1), cerebrovascular accident (n=1) and AML (n=1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7987994	Significance codes according to p value: 0 ‘*’0.001 ‘’0.01 ‘*’0.05 (two-sample t-test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792888	Relative protein expression of cell signaling-related proteins in A549 cells following R. junceus scorpion venom treatment at ½IC50, IC50, 2xIC50 for 48 h. (A) Western blot and bar graph from phosphorylated p38/total p38 ratio. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	e Effects of intraplantar administration of exendin 20–29 (20 μg) on CAP-induced acute thermal hyperalgesia (left) and mechanical allodynia (right) in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6600253	Several targeted therapies that inhibit CDKs, NOTCH, CK2, MDM2, JAK2, and SKIP2 can also promote growth arrest and senescence in tumors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Then, we examined whether we found in CML-BC cell lines was also true for patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "we", "examined", "whether", "we", "...
PMC11531735	Data is presented as Mean ± S.D., statistical significance was calculated using Student t test (*p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "is",...
PMC9031474	The drimanes 14–19 and 2 were active against both cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "drimanes", "14–19", "and", "2", "were", "active", "against", "both", ...
PMC9895440	PT.40245343) and the house keeping gene HPRT1 (Hs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PT.40245343", ")", "and", "the", "house", "keeping", "gene", "HPRT1", "(", "Hs", "." ]...
PMC11607321	and are positive and negative margins, which are hyperparameters tuned as described in the section below.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "and", "are", "positive", "and", "negative", ...
PMC11679033	Using the hepatic stellate cell model, evidence regarding the pro-apoptotic effect of CBD mediated by the elevated basal level of endoplasmic reticulum stress was provided .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11753435	Nonetheless, our results demonstrate that the CLIP model robustly selects and highly ranks target-binding peptides for a provided target sequence, thus motivating its utilization for de novo peptide prioritization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11323699	Remarkably, TAX2 displayed a selective biodistribution pattern in mice, localizing at ovarian tumor sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Remarkably", ",", "TAX2", "displayed", "a", "selective...
PMC9780037	These studies anticipate serum cyt c as a noninvasive prognostic marker in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "studies", "anticipate", "serum", "cyt", "c", "as", "a", "non...
PMC9429973	Accrual continues and updated clinical, NGS and mass cytometry (CyTOF) data will be presented.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accrual", "continues", "and", "updated", "clinica...
PMC11283030	Original magnification 200×; bars, 50 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Original", "magnification", "200", "×", ";", "bars", ",", "50", "μm", "." ] } ]
PMC10969097	This leads to illness and death for individuals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "leads", "to", "illness", "and", "death", "for", "individuals", "." ] } ]
PMC11437637	Notes: The data were compared using a t-test or a Mann-Whitney U test for normally distributed and non-normally distributed data, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notes",...
PMC5941560	Thus, in this study, we used shotgun sequencing to perform genome-scale characterization of genomic variants in this commonly-used cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", ...
PMC9352806	TG content was normalized by the protein content, which was determined according to the instructions of Coomassie brilliant blue kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TG", "content", "...
PMC9429973	Aims: Here, we study the effect of the Q287* mutation on gene expression regulation, as well as GFI1B interaction with LSD1, during induced pluripotent stem cells (IPSC) derived megakaryocytic development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	LAP2 and DAPI are in gray on the left.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LAP2", "and", "DAPI", "are", "in", "gray", "on", "the", "left", "." ] } ]
PMC7759933	Two-dimensional (2D) hepatic cell models, which are generally used for studying the adverse effects of chemicals and consumer products, are prone to giving misleading results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592008	NLRP1 is the main inflammasome sensor and the most prominent inflammasome in the skin .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NLRP1", "is", "the", "main", "inflammasome", "sensor", "and", "t...
PMC11406030	Patients with a higher proportion of cytoplasmic LMTK3 relative to nuclear LMTK3 faced a notably elevated risk of death during the first 1–3 years following diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11638764	30 μL of 25 cells/μL cell suspension was plated in a 384-well plate (Greiner 781080) and CB-5083 was added, final concentration of 10.5 μM to 0.014 μM, and the plate was incubated for an additional 48 h. Cell viability was measured by adding CellTiter Glo reagent and reading the signal with BioTek Synergy Neo2 plate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7812570	The data shown were derived from three independent experiments, and error bars indicate standard deviations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "shown", "were", "derived", "from", ...
PMC3019555	Fig. S3 shows a parallel Western blot and qRT-PCR (Fig. 5), confirming that 2ME2 and TX treatment inhibit HIF-1α protein without affecting total RNA levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	In addition, the results of spleen showed that the proportional of CD8 cells in the HVEM KO group was lower than wild type (Figure S7C–D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7305184	Graphical description of the experiment and forming of experimental groups is presented in the methods (Fig. 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graphical", "description", "of", ...
PMC5386478	These adaptive responses are mainly driven by HIFs, the hypoxia-inducible transcription factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "adaptive", "responses", "are", "mainly", "driven", "by", "HIFs", ...
PMC11342785	Targeting TPPP-CORE to DDX4 droplets triggered weak, but detectable, MT bundling in this assay (Fig. S9, G–I and Video S8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10958426	Three patients diagnosed with colorectal cancer were enrolled in the First Affiliated Hospital, SUSTech.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "patients", "diagnosed", "with", "colorectal", "cancer", ...
PMC11666785	It is evident that the localization precision has improved for corrSMLM, however, the number of localizations has decreased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "evident", ...
PMC11777207	The evidence outlined earlier demonstrates a role for cis PD-L1:CD80 heterodimers on activated DCs for directing cellular movement toward a CCL21 chemokine gradient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10125312	Normal NL20 and THLE-3 cell lines had lower IC50 values around 5 nM, showing the least resistance to higher gold concentrations.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11785489	These results point to families of peptide presentation molecules as the primary source of covariation between the TCR sequence and T cell state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These",...
PMC11748363	We also found that the ‐CF3 substituent still favors activity, as in previous publication (Nawrot et al. 2021), and the position of substitution affects the level of activity, with 4‐CF3 being the most active among others (compounds 30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Standard of care therapies have not changed for many decades and often this intense chemotherapy is intolerable for older patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Standard", "of", "care", ...
PMC11694066	We next assessed the therapeutic potential of an ATRi plus PARPi combination in vivo and evaluated the antitumor effect of PARPi talazoparib, ATRi M1774, or a combination of both agents in mice bearing established xenografts from the JN1 cell line (Fig. 2G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8873393	Several current studies provide molecular insights into the concerted action of CSA and CSB in regulating the timing of transcription arrest and restore.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several...
PMC10698968	E Representative images of hematoxylin and eosin staining of the tumour mass generated by MF-R 3 cells seeded on CAM of chick embryos.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens"...
PMC9429973	Following the 3 treatment block 64% of cases remained MRD-positive (MRD threshold ≥1x10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "the", "3", "treatment", "block", "64", ...
PMC9429973	Dysfunctional signaling can lead to abnormal PLT production causing thrombocytopenia as well as myeloproliferative diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dysfunctional", "signaling", "can", "lead", "to", "abnormal", ...
PMC11470999	All cell lines were verified by STR profiling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "lines", "were", "verified", "by", "STR", "profiling", "." ] } ]
PMC11720808	The EdU incorporation assay was used to analyze the proliferation of osteosarcoma (OS) cells following SCU treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EdU", "incorporation", "as...
PMC11612626	A, Effect of compound A on number of peptides eluted from MHC-I (W6/32) in RPMI-8226 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ",", "Effect", "of", "c...
PMC9429973	Indeed, CD8 T cells showed alterations in their transcriptome, proteome and metabolome leading to cell exhaustion, decreased functions and survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed"...
PMC7342409	Herein, we explored the role of an autophagy inhibitor, chloroquine (CQ) in imatinib-resistant GISTs and elaborated the role of the MAPK/ERK pathway in autophagy inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655498	The cofactor of viral DNA polymerase, BMRF1, is a key protein for lytic DNA replication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cofactor", "of", "viral", "DNA", "po...
PMC11545737	This response was found to be dependent on heat-labile components of OMVs, as heat inactivation of OMVs prevented pyroptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "response", "was", ...
PMC9429973	The selective, orally bioavailable SYK inhibitor entospletinib (ENTO) has demonstrated clinical activity and tolerability in HOXA9/MEIS1-driven AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "selective", ",", ...
PMC11739504	The embryonic body was minced for 3 min using a blade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "embryonic", "body", "was", "minced", "for", "3", "min", "using", "a", "b...
PMC10482220	Previously, it has been shown that arsenite causes most of the cytoplasmic TIA-1 and TIAR (TIA1/R) RNA-binding proteins to accumulate at SGs in human-treated cells (Kedersha et al., 1999).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11627133	We transiently co‐transfected COS7 with a plasmid encoding for the GFP‐tagged POI and a second plasmid encoding AP3‐RhoBAST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "transiently", "co‐transfected", "COS7"...
PMC8041314	The eight classes were screened against these 308 partial structures using the tool InstantJChem, and the absolute statistical distribution of each partial structure was collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11588085	GSEA plot showing Mesenchymal-like Cancer SC Signature enrichment in OVCAR3-KRAB cell with XIST KD. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSEA", "plot", "showing", "Mesenchymal-like", "Cancer", ...
PMC9429973	Aims: To identify the clinical and biological features of CD7+ AML, and evaluate the association of CD7 aberrant expression with response rates and survival parameters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Cytokine secretion from human skin equivalents (K–O) treated with cytokine cocktail with or without 10 µM ML351 for 6, 24 or 48 h (N = 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	Studies have demonstrated that ASNS is a vital transcriptional downstream target gene of ATF4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "have", "demonstrated", "that", "ASNS", "is", "a", "vi...
PMC11261875	Pharmacological and genetic suppression of MCT1 or MCT4 lead to reduced tumor cell proliferation in vitro and in vivo, making them promising therapeutic targets .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11411131	Primary cultured CGCs were transfected with the indicated cDNAs using the calcium phosphate precipitation method at 2 DIV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "cultured", "CGCs", "were", ...
PMC9429973	Students aged 17 to 19 completed a paper and pencil questionnaire and described their knowledge level about Thalassemia, their affective and behavioral attitudes as well as their estimates of hereditary transmission risks and usefulness of prevention measures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Efforts to further improve treatment of plasma EBV positive NKTCL are urgently needed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Efforts", "to", "further", "improve", "treatment", "of", "plasma", "EBV", ...
PMC10926885	The findings demonstrated a correlation between the degree of NDE1 expression and the immunological subtypes of 30 tumours and the molecular subtypes of 17 tumours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11788920	Successively, they were blocked in 5% of nonfat milk in PBS + 0.1% Tween-20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Successively", ",", "they", "were", "blocked", ...
PMC11576293	For C21H23N2O2S (M + H) 367.14748; found 367.14773.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "C21H23N2O2S", "(", "M", "+", "H", ")", "367.14748", ";", "found", "367.1...
PMC10759659	d, e Representative flow cytometric analysis showing galectin-9-positive cells in Hep3B and HepG2/2.215 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "d", ",", "e", "Representative", "flow", "cytome...
PMC7334607	Using increased replicates and additional cell lines would also enhance the analysis of differential gene expression results between responders and non-responders, as we could examine whether differentially expressed genes are consistently dysregulated across different cell lines after exposure to the same experimental conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257203	Furthermore, the MDA level in blood lymphocytes in the group treated simultaneously with indomethacin (100 and 200 μΜ) and curcumin (27 μΜ) decreased significantly compared to the group treated with the same concentration of indomethacin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	After applying the eligibility criteria, 10 articles were entered into the qualitative and quantitative analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "applying", "the", "eligibility", "criteria", ...
PMC9429973	CDA type 1 is inherited as autosomal recessive disorder caused mainly by mutation in CDAN1 gene encoding the codanin-1 protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CDA", "type", "1", "is...
PMC11683130	Reduced expression of SerpinA12 in psoriatic keratinocytes leads to decreased expression of differentiation-related genes (Loricrin, Involucin, Keratin1 and 10) (55), which cause poor differentiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	RG6234 was administered as an IV infusion under a step-up dosing regimen, reaching the target dose not later than 2 weeks after the priming dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10933092	These data were categorized into four groups: gene up-methylation and gene expression upregulation, up-methylation and gene expression downregulation, down-methylation and gene expression upregulation, and down-methylation and gene expression downregulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144382	Thus, altered CRABP2 expression due to MSS-associated NFIX mutations could potentially disrupt RA signaling and lead to the skeletal abnormalities and increased fracture risk, as well as CNS anomalies that are observed in MSS patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682224	Cutaneous squamous cell carcinoma is often hypoxic, and the high expression of VEGF can contribute to the formation of a rich vascular network within the tumour microenvironment, which enables the tumour to grow and expand rapidly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11412721	For estradiol assays, four independent experiments with three independent MEF male clones of each genotype were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "estradiol", "assays", ",", "fou...
PMC11574271	The scale bar above is all 1 µm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "scale", "bar", "above", "is", "all", "1", "µm", "." ] } ]
PMC11694066	Several conventional cytotoxic agents that are in clinical use for the treatment of DSRCT were also identified, such as etoposide and doxorubicin (ranked #4 and #18, respectively; Fig. 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706491	Cells were grown at 30°C in EMM until they reached logarithmic phase to an OD600 = 0.5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "grown", "at", ...
PMC11001582	Fewer proteins were downregulated and with lower fold-changes than upregulated proteins, but, interestingly, GO term enrichment analyses revealed synapse proteins were reduced in lumbar spinal cord of (GR)400 and (PR)400 mice (Extended Data Fig. 8c), consistent with the observed motor neuron loss.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11596967	A variety of molecules, including sulfhydryl compounds, vitamins, dietary antioxidants, phytochemicals, and extracts from plants and bacteria, have demonstrated radioprotective capabilities .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802855	The immunoprecipitated proteins were then analyzed via WB.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "immunoprecipitated", "proteins", "were", "then", "analyzed", "via", "WB", "." ] } ]

PMC11607321

d Fisher skew test per gene across the original CRISPR-Cas9 dataset (x-axis) and the MOSA augmented dataset (y-axis).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Fisher"...

PMC11635087

Chloroplasts were visualized according to chlorophyll autofluorescence (magenta).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chloroplasts", "were", "visualized", "according", "to", "chlorophyll", "autofluorescence", "(", "magen...

PMC8348645

Test for Steroids: Lieberman Burchardt tests: We mixed 0.2 mL of sample with 0.2 mL of chloroform.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Test", "for", "Steroids", ":", ...

PMC5673060

These include the LIM domain family of proteins CRIP2, LASP1, MICALL1 and PDLIM7 which have previously been shown to be localised in focal adhesion complexes and play important roles in mechanotransduction signalling , , .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11423992

This approach relies on the recognition of tumor cell surface antigens and simultaneous binding to the CD3 epsilon chain (CD3ε) within the TCR complex.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC7841189

The results demonstrated that the expression of LTBP2 was also significantly increased in thyroid carcinoma cell lines (Fig. 1C and D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC11774251

Top10 enriched GO terms categorized into biological process, cellular component, and molecular function. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Top10", "enriched", "GO", "terms", "categorized", "int...

PMC3019555

This intriguing result prompted us to examine the spatial and temporal distribution of HIF-1α mRNA after MB transfection in MCF7–GFP-tub cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "intriguing", ...

PMC8806312

Osteosarcoma (OS) is a primary malignant bone tumor with a morbidity of 4,000,000 annually in children and adolescents .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Osteosarcoma", "(", "OS", ...

PMC10968586

On the contrary, 400 μM showed a consistent cytotoxic action at all the assayed time points (24, 48, and 72 h) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9847912

IC50 values were calculated for the HIV-1 isolates using a four-parameter regression model in GraphPad Prism 6.0 as described in the Materials & methods; the regression curves are shown as dashed lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10452486

These two observations put an end to the belief of many investigators that Face-2 results solely from the dissociation of B2m from Face-1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC2196094

A nearly full-length cDNA clone for the rat chymase RMCP-5 was isolated (Figs. 2 A and 5 A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "nearly", "full-length",...

PMC9000591

In general, the SE4 fraction presented the strongest antioxidant activity in both the DPPH and ABTS assays.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "general", ",", "the", "SE4", ...

PMC11670954

Furthermore, BA inhibited the expression of RhoA, ROCK2, and MLCK, and normalized their localization within Caco2 cells.

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PMC9429973

The estimated median overall survival (OS) of the entire cohort was eight (CI 95% 0-16.2) months and was significantly higher in patients who achieved CR compared to those who did not (16.3 months, CI 95% 0-36.2 vs. 2.6 months, CI 95% 1.47-3.7; p value=0.046, figure 1B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Primary causes of death on study included MF (n=7), lung infection (n=1), cerebrovascular accident (n=1) and AML (n=1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7987994

Significance codes according to p value: 0 ‘***’0.001 ‘**’0.01 ‘*’0.05 (two-sample t-test).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11792888

Relative protein expression of cell signaling-related proteins in A549 cells following R. junceus scorpion venom treatment at ½IC50, IC50, 2xIC50 for 48 h. (A) Western blot and bar graph from phosphorylated p38/total p38 ratio. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11612315

e Effects of intraplantar administration of exendin 20–29 (20 μg) on CAP-induced acute thermal hyperalgesia (left) and mechanical allodynia (right) in mice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6600253

Several targeted therapies that inhibit CDKs, NOTCH, CK2, MDM2, JAK2, and SKIP2 can also promote growth arrest and senescence in tumors .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

Then, we examined whether we found in CML-BC cell lines was also true for patients.

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PMC11531735

Data is presented as Mean ± S.D., statistical significance was calculated using Student t test (*p < 0.05).

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PMC9031474

The drimanes 14–19 and 2 were active against both cancer cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "drimanes", "14–19", "and", "2", "were", "active", "against", "both", ...

PMC9895440

PT.40245343) and the house keeping gene HPRT1 (Hs.

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PMC11607321

and are positive and negative margins, which are hyperparameters tuned as described in the section below.

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PMC11679033

Using the hepatic stellate cell model, evidence regarding the pro-apoptotic effect of CBD mediated by the elevated basal level of endoplasmic reticulum stress was provided .

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PMC11753435

Nonetheless, our results demonstrate that the CLIP model robustly selects and highly ranks target-binding peptides for a provided target sequence, thus motivating its utilization for de novo peptide prioritization.

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PMC11323699

Remarkably, TAX2 displayed a selective biodistribution pattern in mice, localizing at ovarian tumor sites.

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PMC9780037

These studies anticipate serum cyt c as a noninvasive prognostic marker in cancer.

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PMC9429973

Accrual continues and updated clinical, NGS and mass cytometry (CyTOF) data will be presented.

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PMC11283030

Original magnification 200×; bars, 50 μm.

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PMC10969097

This leads to illness and death for individuals.

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PMC11437637

Notes: The data were compared using a t-test or a Mann-Whitney U test for normally distributed and non-normally distributed data, respectively.

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PMC5941560

Thus, in this study, we used shotgun sequencing to perform genome-scale characterization of genomic variants in this commonly-used cell line.

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PMC9352806

TG content was normalized by the protein content, which was determined according to the instructions of Coomassie brilliant blue kit.

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PMC9429973

Aims: Here, we study the effect of the Q287* mutation on gene expression regulation, as well as GFI1B interaction with LSD1, during induced pluripotent stem cells (IPSC) derived megakaryocytic development.

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PMC11224020

LAP2 and DAPI are in gray on the left.

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PMC7759933

Two-dimensional (2D) hepatic cell models, which are generally used for studying the adverse effects of chemicals and consumer products, are prone to giving misleading results.

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PMC11592008

NLRP1 is the main inflammasome sensor and the most prominent inflammasome in the skin .

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PMC11406030

Patients with a higher proportion of cytoplasmic LMTK3 relative to nuclear LMTK3 faced a notably elevated risk of death during the first 1–3 years following diagnosis.

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PMC11638764

30 μL of 25 cells/μL cell suspension was plated in a 384-well plate (Greiner 781080) and CB-5083 was added, final concentration of 10.5 μM to 0.014 μM, and the plate was incubated for an additional 48 h. Cell viability was measured by adding CellTiter Glo reagent and reading the signal with BioTek Synergy Neo2 plate reader.

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PMC7812570

The data shown were derived from three independent experiments, and error bars indicate standard deviations.

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PMC3019555

Fig. S3 shows a parallel Western blot and qRT-PCR (Fig. 5), confirming that 2ME2 and TX treatment inhibit HIF-1α protein without affecting total RNA levels.

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PMC11794847

In addition, the results of spleen showed that the proportional of CD8 cells in the HVEM KO group was lower than wild type (Figure S7C–D).

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PMC7305184

Graphical description of the experiment and forming of experimental groups is presented in the methods (Fig. 5).

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PMC5386478

These adaptive responses are mainly driven by HIFs, the hypoxia-inducible transcription factors.

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PMC11342785

Targeting TPPP-CORE to DDX4 droplets triggered weak, but detectable, MT bundling in this assay (Fig. S9, G–I and Video S8).

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PMC10958426

Three patients diagnosed with colorectal cancer were enrolled in the First Affiliated Hospital, SUSTech.

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PMC11666785

It is evident that the localization precision has improved for corrSMLM, however, the number of localizations has decreased.

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PMC11777207

The evidence outlined earlier demonstrates a role for cis PD-L1:CD80 heterodimers on activated DCs for directing cellular movement toward a CCL21 chemokine gradient.

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PMC10125312

Normal NL20 and THLE-3 cell lines had lower IC50 values around 5 nM, showing the least resistance to higher gold concentrations.

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PMC11785489

These results point to families of peptide presentation molecules as the primary source of covariation between the TCR sequence and T cell state.

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PMC11748363

We also found that the ‐CF3 substituent still favors activity, as in previous publication (Nawrot et al. 2021), and the position of substitution affects the level of activity, with 4‐CF3 being the most active among others (compounds 30).

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PMC9429973

Standard of care therapies have not changed for many decades and often this intense chemotherapy is intolerable for older patients.

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PMC11694066

We next assessed the therapeutic potential of an ATRi plus PARPi combination in vivo and evaluated the antitumor effect of PARPi talazoparib, ATRi M1774, or a combination of both agents in mice bearing established xenografts from the JN1 cell line (Fig. 2G).

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PMC8873393

Several current studies provide molecular insights into the concerted action of CSA and CSB in regulating the timing of transcription arrest and restore.

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PMC10698968

E Representative images of hematoxylin and eosin staining of the tumour mass generated by MF-R 3 cells seeded on CAM of chick embryos.

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PMC9429973

Following the 3 treatment block 64% of cases remained MRD-positive (MRD threshold ≥1x10).

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PMC9429973

Dysfunctional signaling can lead to abnormal PLT production causing thrombocytopenia as well as myeloproliferative diseases.

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PMC11470999

All cell lines were verified by STR profiling.

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PMC11720808

The EdU incorporation assay was used to analyze the proliferation of osteosarcoma (OS) cells following SCU treatment.

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PMC11612626

A, Effect of compound A on number of peptides eluted from MHC-I (W6/32) in RPMI-8226 cells.

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PMC9429973

Indeed, CD8 T cells showed alterations in their transcriptome, proteome and metabolome leading to cell exhaustion, decreased functions and survival.

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PMC7342409

Herein, we explored the role of an autophagy inhibitor, chloroquine (CQ) in imatinib-resistant GISTs and elaborated the role of the MAPK/ERK pathway in autophagy inhibition.

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PMC11655498

The cofactor of viral DNA polymerase, BMRF1, is a key protein for lytic DNA replication.

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PMC11545737

This response was found to be dependent on heat-labile components of OMVs, as heat inactivation of OMVs prevented pyroptosis .

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PMC9429973

The selective, orally bioavailable SYK inhibitor entospletinib (ENTO) has demonstrated clinical activity and tolerability in HOXA9/MEIS1-driven AML.

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PMC11739504

The embryonic body was minced for 3 min using a blade.

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PMC10482220

Previously, it has been shown that arsenite causes most of the cytoplasmic TIA-1 and TIAR (TIA1/R) RNA-binding proteins to accumulate at SGs in human-treated cells (Kedersha et al., 1999).

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PMC11627133

We transiently co‐transfected COS7 with a plasmid encoding for the GFP‐tagged POI and a second plasmid encoding AP3‐RhoBAST.

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PMC8041314

The eight classes were screened against these 308 partial structures using the tool InstantJChem, and the absolute statistical distribution of each partial structure was collected.

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PMC11588085

GSEA plot showing Mesenchymal-like Cancer SC Signature enrichment in OVCAR3-KRAB cell with XIST KD. (

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PMC9429973

Aims: To identify the clinical and biological features of CD7+ AML, and evaluate the association of CD7 aberrant expression with response rates and survival parameters.

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PMC11754432

Cytokine secretion from human skin equivalents (K–O) treated with cytokine cocktail with or without 10 µM ML351 for 6, 24 or 48 h (N = 5).

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PMC11525028

Studies have demonstrated that ASNS is a vital transcriptional downstream target gene of ATF4.

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PMC11261875

Pharmacological and genetic suppression of MCT1 or MCT4 lead to reduced tumor cell proliferation in vitro and in vivo, making them promising therapeutic targets .

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PMC11411131

Primary cultured CGCs were transfected with the indicated cDNAs using the calcium phosphate precipitation method at 2 DIV.

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PMC9429973

Students aged 17 to 19 completed a paper and pencil questionnaire and described their knowledge level about Thalassemia, their affective and behavioral attitudes as well as their estimates of hereditary transmission risks and usefulness of prevention measures.

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PMC9429973

Efforts to further improve treatment of plasma EBV positive NKTCL are urgently needed.

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PMC10926885

The findings demonstrated a correlation between the degree of NDE1 expression and the immunological subtypes of 30 tumours and the molecular subtypes of 17 tumours.

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PMC11788920

Successively, they were blocked in 5% of nonfat milk in PBS + 0.1% Tween-20.

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PMC11576293

For C21H23N2O2S (M + H) 367.14748; found 367.14773.

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PMC10759659

d, e Representative flow cytometric analysis showing galectin-9-positive cells in Hep3B and HepG2/2.215 cells.

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PMC7334607

Using increased replicates and additional cell lines would also enhance the analysis of differential gene expression results between responders and non-responders, as we could examine whether differentially expressed genes are consistently dysregulated across different cell lines after exposure to the same experimental conditions.

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PMC11257203

Furthermore, the MDA level in blood lymphocytes in the group treated simultaneously with indomethacin (100 and 200 μΜ) and curcumin (27 μΜ) decreased significantly compared to the group treated with the same concentration of indomethacin.

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PMC9429973

After applying the eligibility criteria, 10 articles were entered into the qualitative and quantitative analysis.

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PMC9429973

CDA type 1 is inherited as autosomal recessive disorder caused mainly by mutation in CDAN1 gene encoding the codanin-1 protein.

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PMC11683130

Reduced expression of SerpinA12 in psoriatic keratinocytes leads to decreased expression of differentiation-related genes (Loricrin, Involucin, Keratin1 and 10) (55), which cause poor differentiation.

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PMC9429973

RG6234 was administered as an IV infusion under a step-up dosing regimen, reaching the target dose not later than 2 weeks after the priming dose.

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PMC10933092

These data were categorized into four groups: gene up-methylation and gene expression upregulation, up-methylation and gene expression downregulation, down-methylation and gene expression upregulation, and down-methylation and gene expression downregulation.

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PMC11144382

Thus, altered CRABP2 expression due to MSS-associated NFIX mutations could potentially disrupt RA signaling and lead to the skeletal abnormalities and increased fracture risk, as well as CNS anomalies that are observed in MSS patients.

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PMC11682224

Cutaneous squamous cell carcinoma is often hypoxic, and the high expression of VEGF can contribute to the formation of a rich vascular network within the tumour microenvironment, which enables the tumour to grow and expand rapidly.

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PMC11412721

For estradiol assays, four independent experiments with three independent MEF male clones of each genotype were performed.

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PMC11574271

The scale bar above is all 1 µm.

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PMC11694066

Several conventional cytotoxic agents that are in clinical use for the treatment of DSRCT were also identified, such as etoposide and doxorubicin (ranked #4 and #18, respectively; Fig. 1B).

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PMC11706491

Cells were grown at 30°C in EMM until they reached logarithmic phase to an OD600 = 0.5.

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PMC11001582

Fewer proteins were downregulated and with lower fold-changes than upregulated proteins, but, interestingly, GO term enrichment analyses revealed synapse proteins were reduced in lumbar spinal cord of (GR)400 and (PR)400 mice (Extended Data Fig. 8c), consistent with the observed motor neuron loss.

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PMC11596967

A variety of molecules, including sulfhydryl compounds, vitamins, dietary antioxidants, phytochemicals, and extracts from plants and bacteria, have demonstrated radioprotective capabilities .

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PMC11802855

The immunoprecipitated proteins were then analyzed via WB.

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