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PMC11469524
We explored how a more quantitative understanding of signaling can be used to describe a conserved B cell receptor regulated signaling network, which can be used as a starting point to quantify cell-specific, individual networks.
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PMC11098378
Interestingly, while the Cys-159 (C159) of Ceg10 is modeled in two roughly equal conformers in data set 1 (PDB ID: 9B8D), in data sets 2 and 3, C159 is modeled in only one conformer as a nitrosylated cysteine, or S-nitrosothiol (PDB ID: 9B8E, Fig 4B and 4C).
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PMC11721295
Furthermore, we showed using quantitative real-time PCR (qRT-PCR) that expression of TGFA, TGFB, CXCL1, and CXCL2 was reduced in MRTX-treated cells (Supplemental Figure 5H).
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PMC9268183
This result is not surprising, based on the previous investigation by Hao et al. , who already pointed out that several phylogenetically-related genera within the family from China contain a series of phytometabolites (e.g., alkaloids, terpenoids, saponins and polysaccharides) with anti-cancer activity .
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PMC11747467
STAT3 mRNA expression levels in luminal and basal cells. (
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PMC5673060
A pie chart distribution using only overlapping phosphosites of both PazR and DasR. Categories include: ‘Up’ (at least 2-times up-regulated versus parental), ‘down’ (at least 2-times down-regulated versus parental) and ‘no change’ (< 2-times up-regulated and < 2-times down-regulated).
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PMC11387401
SupT1 cell lines were cultured in RPMI, supplemented with 10% FCS, Pen/Strep, sodium-pyruvate (1 mM), HEPES (15 mM), Zeocin (150 µg/mL), at 5% CO2 and 37 °C.
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PMC11781181
Future research on SJS/TEN can focus on other diagnostic markers to expand our understanding of their pathogeneses and advance translational medicine by designing exosome-based therapeutic applications.
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PMC6102174
Swerilactone E showed significant anti-HBV activity against the secretion of HBsAg with an IC50 value of 0.22 mM (SI = 9.8) and HBeAg with an IC50 value of 0.52 mM (SI = 4.2), which was more potent than its dehydrogenized derivative swerilactone F [IC50(HBsAg) = 0.70 mM, SI = 2.11; IC50(HBeAg) > 6.78 mM, SI < 1].
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PMC9429973
NCCN-IPI managed to discriminate the intermediate low (IL) and intermediate high (IH) risk groups for both 5y-OS (IL 89% versus (vs) IH 64%, p=0.001) and 5y-PFS (IL 77% vs IH 60%, p=0.029), contrary to IPI (5y-OS IL 69% vs IH 74%, p=0.552; 5y-PFS IL 63% vs HI 64%, p=0.925).
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PMC4270159
In order to determine an appropriate number of replicates to perform initially, we have estimated the sample sizes required based on a range of potential variance.
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PMC11486946
In the case of EGFR, the behavioral transition on the membrane, which is described by EGFR mobility and clustering dynamics, has been shown to correlate to the signaling process: EGF triggers tyrosine phosphorylation, leading to the translocation of EGFR along the membrane to a specific region where the mobility of EGF...
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PMC8143558
The proteins from the disrupted envelopes are then engulfed in saponin molecules in the same way that soaps form micelles around dirt.
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PMC9646302
For data with skewed distributions, nonparametric statistical analysis was performed using the Mann–Whitney U test for the two groups and Kruskal–Wallis test for multiple groups.
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PMC7154001
The information obtained from the studies would help to optimize lead compounds for optimal pharmacokinetic and pharmacodynamic properties.
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PMC11720107
Then, 50 µL of stop solution was added, and the absorbance was measured.
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PMC11794847
At last, ImageQuant LAS4000 Scanner was used to scan the membrane, and Excel-based Analysis Software was used to analyze the relative intensities compared with the control group.
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PMC10502403
All procedures performed in this study involving human participants were conducted in accordance with the Japanese law of Ethical Guidelines for Medical and Biological Research Involving Human Subjects.
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PMC11720107
In the SCC-15 cell line, all tested concentrations (0.062, 0.125, 0.250, 0.500, and 1.000 mg/mL) of the Ornak garlic extract caused a decrease in resazurin reduction by 25.2%, 59.4%, 74.8%, 75.8%, and 75.4%, respectively, compared with the control (Figure 3J).
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PMC9429973
The median PFS in the whole cohort was 20.8 (95% CI 18.43 - not reached) months and the median OS was not reached.
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PMC9429973
Therefore, to receive a balance, we designed a CD33 CAR to recognize AML cells and using NK cells to replace T cells as the carrier to eliminate tumor cells.
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PMC11621493
B, C) Densitometric quantification of acylglycerol bands in rac-18:1 MAG loaded cells in the absence and presence of DGAT inhibitors (shown in A).
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PMC9559528
The complex interactions between autoimmune and infectious diseases in the setting of immunodeficiency present challenges even to experienced clinicians.
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PMC11540664
Based on your suggestions, we further analyzed the situation of local treatments received during the same period in different groups and found that there was no statistical difference between the subgroups in whether or not local treatment was received, which weakened the impact of this factor to a certain extent ( Add...
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PMC11482552
Self-collected sampling has been widely accepted as a method of cervical screening, especially in low-income and middle-income countries .
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PMC9429973
Image: Summary/Conclusion: To date, in this patient population, bomedemstat is generally well-tolerated, reduces platelets, improves symptoms, reduces the mutation burden, and moderates WBC counts without affecting haemoglobin.
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PMC10938336
Notably, these pathways encompass both disease-related processes and fundamental cellular mechanisms.
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PMC11337594
A representative density plot of Annexin V-FITC/PI staining is shown in Fig. 2G.
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PMC11719944
A human prolactin ELISA kit (Fine Test, Wuhan, China) was used.
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PMC11720808
SCU treatment decreased the interaction of endogenous TLR4 and endogenous TRAF6.
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PMC11594641
Guo et al. showed that shRNA- and siRNA-mediated knockdown, as well as CRISPR knockout of RAB27 in B16-F10 mouse melanoma cells, resulted in a comparable effect on the secretion of sEVs.
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PMC10047551
Hypomethylating agents of the azacytidine (AZA) family are cytosine analogs that can be incorporated into DNA and, as a consequence of an irreversible interaction with DNMTs, this results in genome-wide demethylation .
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PMC11687167
Their results showed that the median progression-free survival (mPFS) in the PCSK9 low-expression group was significantly longer than that in the PCSK9 high-expression group (8.1 vs. 3.6 months).
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PMC11627398
In this study, GSEA results showed that compared to low-MTF1 groups, MAPK signaling pathway was more activated in high-MTF1 group.
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PMC9672323
Reports are pointing out that piroxicam, a nonselective inhibitor of the COX enzymes in the category of NSAIDs, possesses anti-edematous and anti-tumor activities besides the known anti-inflammatory actions.
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PMC9429973
Summary/Conclusion: Several large multicenter studies have shown that regimens combining upfront ATRA with chemotherapy lead to high remission rates in APL.
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PMC9220170
At the same time, SELENOM-KD and SELENOT-KD similarly affected the expression of the same selenoproteins; in addition, the silencing of each of them led to an increase in the expression of the other.
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PMC11411131
The SECIS was derived from Toxoplasma gondii SelT. (B) Combinations of promoters for the MeHg sensor.
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PMC11487720
For Western blotting, cells were lysed with a lysis buffer (1% SDS, 0.5% NP-40, 0.1% Triton X-100) in the presence of 7 μL of a protease inhibitor cocktail (Sigma) plus 1 mM PMSF and 1 mM Na3VO4, and incubated on ice for 30 min.
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PMC11727062
The resistance of melanoma cells, such as the human malignant melanoma A375 cells, to chemotherapeutic drugs has unfortunately led to a low survival rate among patients.
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PMC11543935
Pores that do not reverse, initiate apoptosis in cells which is induced by the disruptive effect on cellular integrity and homeostasis.
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PMC11502327
It was found that EXO containing PTX could play a specific role in drug delivery and accumulation in tumor tissues.
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PMC10006224
Sonication was performed with a Covaris S220 (shearing time 30 min, 20% duty cycle, intensity 6, 200 cycles per burst and 30 s per cycle) in a minimum volume of 2 ml.
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PMC9429973
Aims: To evaluate the safety and efficacy of orelabrutinib combined with sintilimab in patients with R/R PCNSL.
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PMC10212663
First, the number of patients in the clinical validation cohort was too small, which may affect the statistical test validity.
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PMC10808409
ROS have the potential to harm cells' DNA, proteins, and fatty acids, which would cause apoptotic cell death.
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PMC11792090
Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized cancer treatment, particularly in hematologic malignancies, by harnessing the patient’s own T cells to target and eliminate cancer cells (1–4).
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PMC11628309
Recent reports have compared various aspects of the SH-SY5Y cells with other neuroblastoma cell lines that show significant promise for neurodegenerative disease research.
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PMC9592219
We found that VP inhibits HCC cell invasion and migration induced by TOP2A overexpression.
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PMC10237474
For His-tagged proteins, 5–10 mL of HisTrap excel column (cat.
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PMC11763533
The more blue-shifted and less sensitive spectrum of this luciferase to pH at lower temperatures becomes more sensitive at higher temperatures, providing a pH indicator better suited to mammalian cells.
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PMC11789597
Additionally, CAV1 knockdown increased the cell surface death receptor Fas, which was also positively correlated with the PFS of bortezomib‐treated MM patients in Mulligan's cohort (Figure S3G,H, Supporting Information).
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PMC7294030
In addition, this cancer has a high incidence of recurrence.
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PMC11269933
The first step involves the transfer of a phosphate group from PEP to ADP, resulting in the formation of an enol intermediate and ATP.
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PMC7039683
First, transcription factors known to bind motifs enriched in the zebrafish periderm enhancer candidates include those previously implicated in periderm development, like Irf6, Grhl3 and Klf17, and novel ones, including C/ebp, Fosl, Gata3 and Tead.
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PMC9429973
On follow up at 6 months; immune paresis had persisted in only thirty seven percent.
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PMC11628904
Larvae were fixed using 4% paraformaldehyde in PBS.
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PMC11747467
Western blot analysis revealed that STAT3 and pSTAT3 are highly enriched in basal cells (J82, 5637, and T24) compared to luminal cells (SW780, HT1376, and RT4) ( Figure 4G ).
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PMC9895440
d Representative flow cytometry plots of SNX9 vs. PD-1 and TIM-3 expression in tumor-infiltrating CD8 T cells of a non-small cell lung cancer (NSCLC) patient.
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PMC11066331
The decrease of TUSC3 expression is visualized by western blotting (A), and by qRT-PCR as mean ± SD fold change (B).Fig.
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PMC11538390
Negative log10 P values (y axis) are plotted for each tested variant against their chromosomal coordinates (x axis) provided in the human genome build GRCh38/hg38.
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PMC7887261
Supporting the hypothesis that deleterious mutations will show lower MAF are recent identifications of several rare missense variants that have a moderate-to-large effect on LC risk, for example, PARK2 p.R275W (OR 5.24), BRCA2 p.K3326X (OR 2.47), CHEK2 p.I157T (OR 0.38), LTB p.L87F (OR 7.52), P3H2 p.Q185H (OR 5.39), DB...
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PMC11453018
On the following day, cells were transfected with 50 nM siRNA targeting human P300 (L-003486–00-0005) and CREBBP (L-003477–00-0005), or a non-targeting scrambled control siRNA (SMARTpool, Dharmacon), employing Lipofectamine RNAiMAX (Invitrogen) as the transfection agent.
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PMC11593031
The likelihood of developing NB varies by age, with the highest incidence in the first year of life and a decrease by age ten .
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PMC10955424
Cisplatin resistance was linked to elevated amounts of IL-6 in ovarian cancer cells, both exogenously and endogenously .
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PMC5308810
SKOV-3 was purchased from ATCC (Manassas, VA) and the GFP-luciferase transfected SKOV-3 (SKOV-3/GFP-Luc) was purchased from Cell Biolabs (San Diego, CA).
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PMC9429973
The main pathological subtype is the germinal center B-cell-like lymphoma(GCB)(74.6%), 46.0% (29/63) were combined with extranodal lesions.
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PMC8427838
The result showed that over-expression of moesin-GFP in RKO cells increased, whereas, expression of TMIGD1 inhibited cell migration (Fig. 4D).
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PMC10565698
We found that circUSP10 expression was upregulated in LC tissues and cells.
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PMC10957991
TRPV4 indicated with red color and DAPI with blue.
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PMC11720107
Therefore, further studies are required to elucidate the role of PPARγ in the mechanism of action of garlic extracts.
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PMC9479186
We found senescence-related pathways were also involved ( Figure 4I ).
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PMC11264242
p < 0.05; **p < 0.01; ****p < 0.0001 (two-tailed Student’s t-test).
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PMC11743414
Fu et al. demonstrated that FHL1 is a powerful prognostic candidate and potential therapeutic target of AML.
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PMC9429973
Aims: To investigate the burden of AHP on mental health, the study evaluated the effects of the disease on social life, personal life/goals, depression, and anxiety.
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PMC11760643
Prior to mAb blockade studies, the half maximal effective concentration (EC50) for the P2X7‐mediated Ca response in HEK‐P2X7 cells was determined.
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PMC11656380
Primary antibodies were obtained from Cell Signaling Technology (CST) (Danvers, MA).
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PMC9341513
Specifically, we used our “highly predictive heteromorphic polymer” (HiP-HoP) model (Buckle et al. 2018; Brackey et al. 2020) to study genomic rearrangements involving the immunoglobulin heavy locus (IGH) (Watson and Breden 2012) and the CCND1 proto-oncogene encoding the cell cycle protein cyclin D1.
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PMC11546117
The formation of a tight barrier at 35 days was also confirmed using an immunohistochemical staining of tight junction proteins.
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PMC8270637
The potential NFATc1 response elements were found within 1.5 kb upstream of the transcriptional start site.
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PMC11453346
T. Bock: None.
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PMC9479186
Kaplan–Meier survival curve shows that high NDUFC1 expression indicates a low over-all survival rate.
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PMC11470999
Statistical significance between two groups was assessed using a two‐tailed Student's t‐test.
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PMC11747949
p < 0.05, **p < 0.01, ***p < 0.001, significance was determined using the Student's t‐test, n = 3 per experimental group.
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PMC11720107
Discrepancies between studies are likely due to differences in the garlic dose, cultivar, type of cells, and exposure duration.
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PMC11782508
Additionally, multiple peaks between δ 5.2 ppm and δ 2.1 ppm were attributed to various aliphatic hydrogens in the protein structure.
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PMC9412887
Microneedles can penetrate the immune cell-rich epidermis and induce a strong immune response by stimulating the function T cells .
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PMC7334607
As seen in Methods, this necessitated an increase in the final VDC drug combination concentration.
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PMC11549612
Further findings of this study reveal intriguing associations between BOLA1, BOLA2, and BOLA3 expression levels and distinct immune subtypes within KIRC.
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PMC11637716
At the time of publication, three of these four patients had already died at the age of less than 2 years, while one 15‐month‐old patient was still alive.
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PMC10606998
The dose rate was 0.15–0.3 Gy/min.
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PMC11537649
Use Image J to analyze the scratch area and use the GraphPad prism (GraphPad Software, Inc., La Jolla, CA) for image output.
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PMC11367939
Finally, understanding the distinct trafficking, sorting, and biogenesis of ATG9A vesicles at presynapses can provide insights into the functioning of these vesicles in neurons and how they can be incorporated into presynaptic autophagy and related diseases.
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PMC11755519
Prospero homeobox 1 (PROX1) is crucial in the formation of the lymphatic vascular system and is responsible for the regulation of endothelial cell differentiation and induction of lymphatic endothelial cell budding.
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PMC11397654
To confirm the activity of the compounds, the exodus of high mobility group box 1 (HMGB-1) of cells after treating them with calixarenes and PTX was investigated.
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PMC11730305
Furthermore, cell cycle analysis indicated that in the untreated cells, 58.2% of cells were at the G0/G1 phase, followed by the S phase.
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PMC9919300
The purple formazan was quantitated by measuring the absorbance at 540 nm with a reference wavelength of 630 nm by a microplate reader (OPSYS MR, Dynex Technologies, Chantilly, VA, USA).
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PMC11543853
The high virus dose was required to enable observation of a representative number of enterovirus particles in the high-magnification tomograms, each of which represents only 0.17% of the area of an average cos-7 cell.
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PMC11747885
Reactive oxygen species (ROS) are linked to various diseases, including neurodegenerative disorders and cancer, where RNA damage has significant effects.
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PMC8708099
no. 15596026), and, after 5 min of incubation at room temperature, 0.2 mL of chloroform (Chempur, Piekary Śląskie, Poland, cat.
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