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PMC11637284
Pictures were acquired on a DMI6000B microscope equipped with a DFC360 FX monochrome camera and LAS X software (Leica Microsystems).
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PMC7433824
All the tested doses inhibited growth and the degree of inhibition correlated with the applied dosage.
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PMC9429973
The mean and median platelets count at both time of diagnosis and time of last contact in the observation group were higher than that of the treatment group at time of diagnosis (26 vs 15.4 x 10/L) with a significant statistical correlation, and comparable at time of last follow up (200.7 vs 210.4 x 10/L) with negligible statistical correlation.
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PMC7189327
However, the underlying pathogenic mechanisms of the four-gene signature (CYFIP2, MARCKSL1, HOXB5, and PTPN3) for BCC progression have not been expatiated.
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PMC11739484
The magnitude of these coefficients reflected the impact of variables on hazard rates, assisting in the construction of prognostic models for survival outcomes.
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PMC3274243
As such, the system has shown potential applications in research, toxicology and theranostics.
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PMC9583612
Bridger reported emissions by location on site without source identification to specific equipment.
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PMC11001582
Expression of polyPR is also toxic in mice.
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PMC11093197
In our previous study, RB1 deficiency enhances N‐RAS activity, leading to DNA damage‐based cellular senescence in calcitonin‐positive adenoma.
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PMC11489351
Fluorescence intensity from individual cells is shown in a scatter plot (medians shown in red line) from three biological replicates.
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PMC11791478
Furthermore, XB002 induced significant tumor growth inhibition, with some cases showing complete regression in PDX models representing various solid tumors.
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PMC11754094
The following day, the sgRNA library lentivirus was added to the cultured HeLa CRISPRi cells in the presence of 8 µg ml polybrene.
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PMC11792888
The mean fold change was plotted for each sample on a bar graph. *
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PMC9429973
DAC activated a series of endogenous retroviruses (ERV) and upregulated TLR3 which activated anti-tumor immunity by promoting IFN-α secretion.
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PMC11727638
The Cell Dome offers distinct advantages over existing 3D culture techniques, including improved handling of non-adherent cells, ease of operation and reproducibility, and the ability to mimic the in vivo microenvironment more accurately.
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PMC11587541
A study by Rossiello et al. demonstrated the association between telomere shortening and various neurodegenerative disorders including SMA, which has also been observed in various mouse models.
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PMC11740573
Niu et al. showed that calcitriol significantly decreased the number of live Porphyromonas gingivalis internalized into epithelial cells, monocytes, and macrophages by promoting autophagy .
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PMC2614415
TMA sections were stained at the WCI Tissue and Pathology Core Facility with H&E and with Aurora A antibody (1:300 dilution, Abcam, Cambridge, MA).
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PMC11247842
The second strongest association signal was found on BTA9 at 10,457,304 bp (rs133164262), with an intergenic variant near bta-mir-30f as the lead SNP is.
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PMC10969097
This increases the sensitivity of hepatoma cells to treatment and thus potentiates the inhibitory effect of oxaliplatin .
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PMC9621239
The mean heterogeneity of HBV QS across X gene in tumour tissues was lower than that in non-tumour tissues.
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PMC9429973
Within this group, only the age (p=0.079), the blast count (%) in bone marrow (p=0.05) and belong to intermediate-adverse European LeukemiaNet-2017 (ELN2017) risk group (p=0.008), were significantly associated with a shorter OS in the univariate analysis When confronting these variables with the presence of a platelet count at diagnosis over 300x10/L, only intermediate-adverse ELN2017 risk group and the platelet count remained significant for a shorted OS (p=0,023, HR 2.17, 95%CI 1.11-4.24 and p=0.025, HR 3.50, 95% CI 1.16-10.54, for platelet count and ELN risk group, respectively).
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PMC10955424
In this study, we examined the ability of ascites fluids derived from OC patients in comparison to non-malignant cirrhosis ascites to affect platinum sensitivity of OC cells.
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PMC11472569
These EVs can encapsulate and export chemotherapeutic drugs out of the cell, reducing intracellular drug concentrations and contributing to enhanced drug resistance.
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PMC11802929
Cells expressing HPhobic-High TCRs were more clonally expanded than HPhobic-Low ones (Fig. 5e bottom).
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PMC8873393
Interestingly, the average exon length of the “recovered” annotated lncRNAs is longer than that of the repressed lncRNAs (114.0 nt for the “recovered” annotated lncRNAs and 106.3 nt for the repressed lncRNAs) (Fig. 5G).
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PMC11750712
However, given the late timing of these reactivations and lack of CAR T cell persistence and lymphopenia at the time, these are unlikely to have been caused by AUTO4 CAR T cells.
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PMC11786704
Schematic diagram of wound healing. (
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PMC9429973
In a combined analysis of Gr2-4 and Gr6-8, prognostic factors according to ELN2017 identified three clearly separated subgroups, with the favorable subgroup predominantly associated with mut.
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PMC11063646
The current study employs the CCD to construct linear/quadratic equations for response variables through five-level two factorial trials.
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PMC11733919
Thus, perhaps NF-κB might mediate the MNP@CD26@17D-based ferroptotic response in senescent skin cancer cells, but more evidence is needed to confirm such assumptions.
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PMC7334607
Additionally, one of the control evolutionary replicates has an outlier EC50 estimate, which causes the pre-treatment (Pre-Tx) experimental evolutionary replicates to appear more sensitive to cyclophosphamide than the control evolutionary replicates.
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PMC9429973
Results: We collected 79 patients.
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PMC11367939
The endocytic origin of these vesicles further suggests the existence of different intracellular sorting or segregation mechanisms for ATG9A and synaptophysin in cells.
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PMC10874773
Consequently, we have compiled their names, associated activities, and sources in Table 1.Table 1Seco-prezizaane-type sesquiterpenes found in Illicium plants.
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PMC9429973
At the end of follow-up, 44 patients (29.3%) were deceased, and mean time to death among deceased patients was 6.5 (standard deviation, 2.7) months from initiation of FEDR.
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PMC9429973
Thus, myTcell has the potential to improve guideline adherence and accelerate broader and safer application of CARs and BiTEs.
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PMC11621493
Extracts were pooled, dried under a stream of N2, and analyzed by TLC using chloroform/acetone/acetic acid (v/v/v, 88/12/1; two-thirds of the plate) as the first mobile phase and toluol as the second (full plate).
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PMC11471157
Pinna fibroblast CAF cells were sourced from the RIKEN Cell Bank (Ibaraki, Japan).
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PMC11388384
We generated an SHH-Halo allele that lacks cholesterol and found that the population of SHH-Halo molecules diffusing at ~1 µm/s was dependent on the cholesterol modification, whereas other populations were unaffected (Fig. 2E).
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PMC11792888
Meanwhile, Macrothele raveni venom activates p21, arresting the cells at G2/M in the human hepatocellular carcinoma cell line HepG2 .
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PMC11653533
The milky juice and seeds can be used locally for wounds, ulcers, cracked or irritated foot soles, and rheumatism for relief (Murti et al., 2010).
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PMC11512230
Secondly, the particles must also have the ability to adhere to target cells.
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PMC11453018
C Immunofluorescence for Ki67 (red) expression in SKES1 cells indicates cell-cycle arrest after 48 hours of iP300w treatment (1 µM).
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PMC10820104
Antismash and InterProScan Version 5.58-91.0 were used to detect gene clusters and identify potential genes of interest.
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PMC11395280
Calcium Mobilization assays CCRF-CEM cells were resuspended at 1.5 × 10 cells/mL in Hanks Balanced Salt Solution (HBSS)/Fluo-4 AM (Invitrogen, F14201) for 45 min with gentle inversion every 5 min.
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PMC10507284
Statistical tests: Student's t‐test. (
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PMC11471157
Inner surface after processing. (
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PMC11629143
Global HDAC inhibition using small molecule drugs like sodium butyrate can induce histone hyperacetylation at transgene promoters and increase the expression of transgenes and endogenous genes in CHO cells .
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PMC9429973
Of 23 pts with R/R AML (median 3 prior Rx, 78% with ≥1 prior FLT3i including prior gilteritinib in 70%, and 39% had a prior alloSCT), 78% achieved CRc (3 CR, 15 CRi) with 6/16 and 5/18 responders achieving FLT3-PCR and multicolor flow cytometry negativity, respectively.
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PMC11519788
In TCGA-BLCA and GSE13507 datasets, VEZF1 mRNA was significantly downregulated in UBC samples (Figure 7D-E), and VEZF1 protein was lower in another 24 UBC tissues than the paired normal ones (Figure 7F-G).
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PMC8382973
Microbicides circumvent viral infection of targeted cells and therefore hold promise for anti-HIV infection.
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PMC10955424
Because of late-stage diagnosis, HGSOC accounts for most OC death cases .
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PMC11126803
The concept of VM, epithelial cell-independent angiogenesis, has received increasing attention "since it was first reported by Maniotis in 1999" (15).
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PMC9429973
Transcriptomic analysis of DNMT3A and NPM1 positive AML cells indicated distinct transcriptomic profiles, characterized by high expression of homeobox genes, involved in determination of cell faith.
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PMC10729469
Snap-frozen mouse cortex was homogenized in 50 mM Tris–HCL (pH 7.6) containing 150 mM of NaCl and a protease inhibitor.
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PMC10079526
Furthermore approximately 15–30% of diffuse large B-cell lymphomas (DLBCL) has a MYC translocation, often in combination with partner mutations, which is a negative predictor of disease outcome .
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PMC11761919
The introduction of inulin or PINs to recombinant E. faecalis did not inhibit but rather promoted bacteria growth.
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PMC11026382
Each point represents one triplicate experimental measurement.
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PMC9352806
P-values were analyzed by log-rank (Mantel-Cox method) tests.
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PMC9429973
However, its chemical and pharmacological mechanisms remain to be elucidated.
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PMC11730311
Results are presented as mean ± range of n = 3.
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PMC6643347
Various dilutions of the test compound were added to the cells and incubated for 45–90 min at 37°C.
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PMC9874064
Finally, to visualize the DNA damage by NP-Pt-USP1i, the γ-H2AX in cells was stained with an immunofluorescence (green) assay.
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PMC10887351
Under hypoxic conditions, β3-ARs were over-expressed in the TME and increased cancer growth with the recruitment of circulating stromal cell precursors to the tumor sites, together with improvement of stem cell traits .
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PMC11301242
To investigate the potential functions of circular ecDNA amplification, we first annotated the ecDNA amplicon peaks.
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PMC11665584
To test these effects on wound healing dynamics, we performed full-thickness excisional wounding with 6 mm biopsies on the dorsa of control and PITX1 mice and tracked healing over 12 days (Figure 6A).
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PMC6379402
In the same way, we observe that the wiring patterns of iCells are different from those of the constituting PPI, COEX, and GI networks.
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PMC11672142
Then, 1 μL of sample solutions was placed on top of the crystallized matrix and allowed to crystallize.
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PMC9545714
This enzyme has been shown to ω‐hydroxylate lauric and myristic acid and to be capable of hydroxylating a variety of aliphatic and aromatic substrates.
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PMC9429973
Regarding responses on those treated with CMT 64% (n=46) obtained Complete Remission (CR), subsequently 37 pts (51%) received consolidation with high doses of CMT, 13 pts relapsed, and 26 received HSCT.
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PMC9429973
The primary endpoint, 2-month OS, was 83.3% in 12 evaluable patients, both patients died due to lymphoma progression.
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PMC11721295
This gives a multiplicity-adjusted P value for each comparison, which is reported.
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PMC9429973
Methods: Patients were randomized to receive 2 intravenous infusions at a 7-day interval of either MSC 2 x 10/kg body weight or placebo.
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PMC11607321
Although linear dimensionality reduction models have been designed for similar purposes, the application of deep generative models to large-scale multi-omic cancer cell models is lagging behind.
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PMC11001582
Genotypes: w; GMR-Gal4/+, w; GMR-Gal4/UAS-Mp RNAi, w; GMR-Gal4, UAS-GR36/+, w; GMR-Gal4, UAS-GR36/UAS-Mp RNAi.
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PMC11380329
These observations support the hypothesis that co-supplementation of Vit D with different types of P, enhance the antitumor activities on OVCAR4 ovarian cancer cell line.
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PMC11705630
Caliper was used to measure tumor growth twice a week.
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PMC11637284
Despite the presence of conserved charged residues in either protein, electrostatic interactions are not necessary for contact site formation.
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PMC11714165
In contrast, the unmodified NBD peptide demonstrated poor anti‐cancer activity due to limited cellular internalization.
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PMC11670407
On the following day, the sections were stained with BCIP/NBT (AR1023, Boster, China) following an incubation period of 1 hour at room temperature with biotinylated goat anti-rabbit IgG secondary antibody.
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PMC11736898
Expression of CYP24A1 protein in keloids and normal skin samples.
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PMC9429973
PLT recovery was observed in 10 (71%) ASCT patients with a median time to recovery of 35 days from the stem cell infusion (range 13-136).
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PMC9429973
S. Huhn, A. M. Poos, E. K. Mai, M. Hänel, H. J. Salwender, J. Dürig, I. W. Blau, C. Scheid, K. C. Weisel, M. Munder, O. Berlanga, U. Bertsch, H. Goldschmidt, N. Weinhold Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg; Department of Internal Medicine III, Clinic Chemnitz, Chemnitz; Asklepios Tumorzentrum Hamburg, AK Altona and AK St. Georg, Hamburg; Department for Hematology and Stem Cell Transplantation, University Hospital Essen, Essen; Medical Clinic, Charité University Medicine Berlin, Berlin; Department of Internal Medicine I, University of Cologne, Cologne; Department of Oncology, Hematology and BMT, University Medical Center Hamburg-Eppendorf, Hamburg; Third Department of Medicine, University Medicine Mainz of Johannes Gutenberg, Mainz, Germany; The Binding Site Group, Ltd, Birmingham, United Kingdom Background: Mass spectrometry has broad potential for screening and monitoring monoclonal gammopathies.
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PMC11718031
Based on our analysis, cysteine and serine were consumed the most during the fed-batch run (Fig. 5).
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PMC11599565
CSC phenotypes can also be induced with nitric oxide, which disrupts the Oct-4:Caveolin-1 complex.
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PMC9429973
Approximately 15%-20% of patients with MDS presenting with marrow hypoplasia for age would be incorrectly categorized as AA, which the pathobiology and prognosis are distinct from hypoplastic MDS (hypo-MDS).
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PMC10850553
The Plasmin-dependent enzymatic cleavage of C5a from C5 was further confirmed in a cell-free system using recombinant C5 protein and the exogenous recombinant Plasmin (Fig. 6C, Supplementary Fig. S6).
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PMC11673902
At the same time, high-speed cameras capture images of cell deformation, and automatic image analysis algorithms quantify cell size and degree of deformation and create a 2D scatter plot.
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PMC9429973
Prophylactic treatment was started at age 57 after she developed a spontaneous subdural hematoma.
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PMC11300639
Wogonin or palbociclib, when applied to 786-O cells resistant to sunitinib, can effectively reverse RCC resistance to sunitinib .
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PMC11747467
A gDS > 0 indicates that deletion of this gene has no effect on cell viability.
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PMC11740508
Improved growth inhibition by the combination over PARPi treatment alone in several preclinical models prompted phase 1 clinical trials in leukemia and in breast cancer (ClinicalTrials.gov Identifier: NCT04134884).
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PMC11706491
Balancing image acquisition frequency with photobleaching mitigation strategies could optimize experimental conditions, allowing for more comprehensive cell cycle monitoring.
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PMC9429973
Cidofovir represents a valid therapeutic option.
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PMC8389560
Statistical analyses were performed by paired t-test.
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PMC9429973
PIK3IP1 expression is associated with oncogenic markers and poor outcomes in AML.
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PMC11701801
Cell viability was measured after treatment with an inhibitor, and the cells were trypsinized, counted, and reseeded in 96-well plates at a density of 500 cells per well.
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PMC9429973
She refused bone marrow examination.
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PMC11401350
FACS analysis to determine the % of CD8 T cells (D) and CD4 T cells (E) 6 days post-transduction in the mAITL biopsies (mean (SD), No vector n = 3; PGK-CAR n = 8, PGK-GFP n = 3; one-way-Anova; ****p < 0.0001).
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