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OTAR3088
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BioData-CellLine_annotated

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PMC7504302
However, the activation status of this pathway failed to differentiate between malignant and nonmalignant cells, highlighting a complex regulation in MPM .
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PMC9429973
Mean time to HSP-CAR30 cell peak level across all doses was 29 days (range 6–98).
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PMC11727062
Moreover, in a xenogeneic animal model, the administration of brusatol resulted in a significant decrease in melanoma tumor volume and weight, along with a reduction in the drug’s toxic side effects.
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PMC7090062
P < 0.05 vs. Control.
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PMC11682172
Coronin 1A-IF FOC intensity-levels in the breast cancer cell lines before and after 72 h of co-culture with activated T lymphocytes.
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PMC10237474
As expected, CHO-K1 expressed proteins 5 and 6 were too heavily glycosylated to be ionized efficiently, resulting in no or poor MS signal (S5A and S5B Fig, CHO-K1 panels).
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PMC11739696
Their small size, high surface area, and catalytic activity make them suitable for diverse biomedical applications, ranging from drug delivery to imaging and photo-thermal therapy.
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PMC8270637
Next, we tested whether TGF-β1 treated T cells had higher apoptosis level after co-cultured with HCC cells.
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PMC9454178
The upregulated and downregulated genes are highlighted in red and blue, respectively.
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PMC11711663
The nomogram serves as a valuable addition to clinical practice by facilitating shared decision-making and promoting precision medicine approaches in the management of HNSCC.
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PMC6771295
Exogenously introduced CD20 is delivered on cell surface which is tagged by APC-H7 conjugated CD20 IgG antibody.
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PMC7642379
Genomic DNA was extracted using the Blood and Cell Culture DNA Mini Kit (Qiagen) according to the manufacturer’s guidelines and concentrations were determined by using a NanoDrop ND-1000 spectrophotometer (Thermo Scientific).
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PMC11756907
It is most often assumed that the binding energy corresponding to this peak is EB = 285.0 eV. Depending on the needs or possibilities, the energy scale of the spectra can be standardised using other reference values of the binding energy (eg EB = 284.8 eV, or EB = 284.7 eV).
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PMC11144200
After that, the diluted collagen I (Sigma, USA) was incorporated, and it soaked for 30 min under a water bath at 37 °C.
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PMC9429973
Kidney damage was presented in 33 pts (37%).
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PMC10698968
For each filter sample, five random fields were counted.
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PMC10502403
The final concentrations of oligomycin, FCCP, and rotenone/antimycin A were 1.5, 1.0 μM and 0.5 μM, respectively.
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PMC10955424
Median cPARP/GAPDH band density relative to control is indicated (B).
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PMC10213179
Statistical significance was achieved by Student’s t test from at least three different experiments: ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001, ∗∗∗∗p ≤ 0.0001.
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PMC6600592
m.p.
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PMC9429973
Furthermore, while both EOT CECT and PET response were prognostic for PFS and OS, only PET response remained prognostic for OS following adjustment for stratification factors suggesting it is a superior prognostic tool in PTCL.
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PMC9424261
Data were analyzed using Student’s t test and expressed as mean ± SD from three independent experiments. **
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PMC11770130
Male mice aged 10–12 weeks were anesthetized with isoflurane (3%–4% isoflurane for induction and 1%–2% isoflurane for maintenance) by intraperitoneal injection and then mounted in a stereotaxic apparatus (RWD, Model 68045).
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PMC11770199
For HCT8 cells, hMSCs-14 versus hMSCs-GFP at a ratio of 1:5, **P = 0.004; at ratio of 1:12.5, ***P < 0.001; at ratio of 1:25, **P = 0.001.
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PMC10587429
We showed that this model is suitable for pediatric cancer research because human immune cells were reconstituted early in young mice ( Figure 2 ).
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PMC11514418
Pancreatic cancer patients can receive palliative treatments like chemotherapy or supportive surgery to extend their survival.
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PMC11536589
It is the third leading cause of cancer-related death in the United States (Park et al. 2021) and the seventh globally (Sung et al. 2021).
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PMC11036064
Besides deep in-silico studies, in-vitro studies were performed to better understand the effect of the hsa-miR-34a-5p ectopic expression on the intracellular signaling pathway of GBM.
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PMC11026382
When assessing model performance against the larger set of TYMS variants (as in Fig. 2) we refit all parameters (, , , , [DHFR], [TYMSWT], [TYMSR166Q], [TYMSQ33S], [TYMSR127A], foltot) to the growth rate data only since we did not have metabolomics data for this larger set.
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PMC11756907
Comparison of cytotoxicity of tested samples dissolved in ethanol and DMSO against 143B cells expressed as % of cells viability.
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PMC9429973
R. Ludwig, D. Amend, E. Bahrami, I. Jeremias Apoptosis in Hematopoietic Stem Cells, German Research Center for Environmental Health (HMGU), Munich; German Cancer Consortium (DKTK), partner site Munich; Department of Pediatrics, University Hospital, Ludwig Maximilian University (LMU), Munich, Germany Background: Acute leukemias require better treatment and targeted therapies represent interesting future therapeutic options.
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PMC11588008
Third, after the administration of ERK inhibitor, the apoptosis rate of cells increased.
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PMC11655536
E The expression of Ki67 between control and HA.
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PMC11705862
They also modulate neuronal excitability by influencing Ca levels and releasing gliotransmitters .
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PMC2777936
For shRNA lentiviral constructs, infected cells were selected by addition of 0.5 μg/ml puromycin (Sigma-Aldrich, MO).
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PMC11098378
Future studies will be needed to determine how the generation of v2-cADPR or the resulting NAD depletion breaks viral restriction, as well as the functional role of HopT1-2 during infection.
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PMC11741906
The current work demonstrates that Nine miRNAs were found to be upregulated in cells resistant to cisplatin.
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PMC11765243
Furthermore, anti-CD3 activation was carried out in the presence of 10 µg/mL of anti-CD28 antibody.
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PMC11746948
c Immunofluorescence staining of GPX4 in A375 cells treated with 2-BP for 48 h. Scale bar, 10 μm.
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PMC8623816
It has been previously reported that a large number of partitiviruses have been identified in phytopathogenic fungi, but few of them have been involved in the hypovirulence of their host fungi .
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PMC10852540
When the cells reached the logarithmic phase, vehicle control, DOX IC50 = 0.08 μM, and RA IC50 = 437.6 μM were administered singly and in combination.
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PMC4485786
Strikingly, within 5 d IFN-γ and TNF also massively induced the number of bi- and polynucleated cells in sarcoma cultures (Fig. 7B, C), suggesting a p16-mediated irreversible block of cytokinesis.
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PMC2118063
These data indicated that IRF8 bound the endogenous promoters of AICDA and BCL6 in a mouse GC B cell–derived cell line and in human tonsillar B cells.
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PMC11733919
This result confirms that the nanoplatform is indeed taken up by senescent cells.
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PMC10170482
Using the high-resolution and ultrafast confocal imaging system, we determined the average pore size of CS to be 121 ± 40 μm and the fiber diameter to be about 1.8 ± 0.7 μm (Figure 2A).
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PMC10523483
H1.2 knockout resulted in down-regulated NRF2/GCLC/GSH axis, elevated ROS levels, and worse survival in cisplatin-treated NSCLC cells, while H1.2 overexpression had the opposite effects (Fig. 7 C–J), implicating its potential as a predictor for chemotherapy response.
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PMC11618052
C NMR (100 MHz, δ ppm CDCl3): 161.37, 155.65, 147.31, 144.63, 138.97, 134.66, 134.42, 130.23, 127.12, 125.84, 125.74, 121.11, 120.48, 119.56, 39.82, 26.66, 21.10, 13.26.
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PMC10958426
This observation is consistent with the recent studies reported the highly expressed genes in tumor usually have a lot DNA copies in the form of extrachromosomal circular DNA (eccDNA) .
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PMC9429973
During maintenance treatment, 6 patients (19%) had improvement of response: 1 SD to MR, 3 PR to VGPR, 1 VGPR to CR and 1 VGPR to sCR.
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PMC6024716
Three batches of cells from each cell line were analyzed.
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PMC11683240
Sequentially ADP-ribosylated Gαi, which was previously biotin-labeled, was detected using streptavidin-peroxidase (Strep-POD, Sigma-Aldrich, Merck).
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PMC11742231
Then, an adaptive fusion module is proposed to match the drug representation and fused CCL and fingerprint representations.
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PMC10850553
Human IA lesions were harvested subjected to immunohistochemical analyses.
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PMC9428827
Mouse transplantable tumor cell lines used melanoma MB16, colon CT26, mammary tumor 4T1, lung carcinoma 3LL-D122, and lung carcinoma TC1 cells maintained in Dulbecco’s modified Eagle medium (DMEM) F12 (GIBCO, Grand Island, NY, USA) supplemented with 10% heat-inactivated fetal bovine serum, 2 mM of l-glutamine, 50 U/ml of penicillin, 50 μg/ml of streptomycin.
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PMC11739696
Therefore, the current study was conducted to estimate the effect of Co3O4NPs exposure on cell viability, genomic and mitochondrial DNA integrity, ROS generation and apoptosis induction in human melanoma A-375 cells.
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PMC11782508
Further investigation was performed using the Minimum inhibitory concentration (MIC) assay.
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PMC9429973
Given the low number of deaths, we chose to include only the biological parameters at admission in univariate and multivariate analysis.
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PMC11789597
MM1S cells were treated with 1087 FDA‐approved drugs and the expression of CAV1 (green) was determined using in‐cell western.
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PMC11756937
For harvesting, the EBs were washed in PBS, resuspended in RLT lysis buffer (Qiagen) and processed for RNA extraction.
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PMC11733919
Muse Cell Analyzer was used to reveal four cell subpopulations [%], namely, live cells (negative for both stainings), early apoptotic cells (Annexin V-positive cells), late apoptotic cells (positive for both stainings), and necrotic cells (7-AAD-positive cells).
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PMC11394227
In addition to the fact that the co-overexpression of EQK and survivin in CHO-PAb-QS cells would impose a specific load on the ER, the enhanced folding capacity of disulfide bonds and the accelerated synthesis of antibodies in CHO-PAb-QS cells would collectively activate the endoplasmic reticulum UPR.
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PMC9429973
3 patients underwent liver transplantation.
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PMC10523483
These results indicated a tumor-driving role of H1.2 in NSCLC.
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PMC9429973
Its availability in Greece coincided with severe blood shortages due to the COVID outbreak, making its administration even more necessary.
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PMC6222726
From the acetonic extract of the bark, Hernandez isolated a new lignan named ariensin (12) .
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PMC11489275
The results showed that the lymphocyte count and Duration were significantly lower in 1-month non-survivors with statistical differences (Table 1).
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PMC9583612
Measurements in both basin A and B show that distribution of individual emission measurement from tanks span over 3 orders of magnitude—from as low as 10 scfh to over 10 000 scfh.
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PMC8348645
Table 4).
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PMC11720808
The regulatory effects of herbal monomer components on the nuclear factor-κB (NF-κB) pathway is of considerable and growing interest.12,13 NF-κB is an important transcription factor family that has five members, p65 (RelA), RelB, c-Rel, NF-κB1 (p105/p50), and NF-κB2 (p100/p52).
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PMC11534377
Our microarray analysis identified significant changes in gene expression in A549 cells post-5-Aza treatment.
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PMC8358006
f Venn diagram of gene comparison between GSDs marked and GSDs targeted.
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PMC11637284
Flagella extraction was performed as described previously .
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PMC11653533
Besides, chloroform extraction of F. benjamina steam and leaves has manifested hemolytic activity with a percentage value of 3.36 and 3.29, respectively (Imran et al., 2014).
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PMC11656657
Figure created using Biorender—https://biorender.com.
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PMC10988555
After the incubation, the culture media was replaced by fresh medium with 10× the IC50 of the different complexes or 0.1% (v/v) of DMSO, as for ICP-AES.
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PMC11402217
Furthermore, a wound healing assay revealed that treating 143B cells with 0.5 μM XD23 for 6 h led to a notable 34% reduction in wound closure, indicating a potent suppression of OS cell invasion by XD23 (Figures 3B and 3C).Figure 3XD23 deters OS cells migration by impeding EMT differentiation(A) Transwell migration assay showing concentration-dependent inhibition of 143B cell invasion by XD23.(B) Wound healing assay demonstrating the inhibitory effect of XD23 (0.5 μM) on 143B cell migration and (C and C) the normalized wounding areas.
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PMC11604768
Data were scaled to the Fluc/Rluc ratio in untreated cells (N.D. – no drug).
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PMC8358176
All death receptors consists of a conserved cytoplasmic polypeptide that contributes to the cognition of apoptotic machinery ( 12 ).
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PMC11502962
Real-time PCR was quantified using Hieff qPCR SYBR Green Master Mix Kit (Yeasen) and performed on iQ5 Opticon System (Bio-Rad, Hercules, CA).
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PMC8973085
calcd for C25H22FN3O4S: C, 62.62; H, 4.62; N, 8.76.
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PMC11792090
Additionally, Western blotting results showed significantly elevated levels of activated STAT5 and BCL2 in SAP UCAR-T cells under cytokine-free conditions ( Figures 4H–J ).
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PMC10698968
MF-R 3 cells are also a suitable tool to generate diverse 2D and 3D near-patient preclinical models that may be useful to deepen the knowledge of MFS pathogenesis and drugs response.
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PMC8358006
c H3K27me3 difference for GSDs marked gene (mean values; x-axis) plotted against expression of the corresponding genes (y-axis; log2 values) in KYSE450 cells versus NE2 cells (along axes): red, selected H3K27me3 losses and upregulated genes; blue, H3K27me3 gains and downregulated genes; and black diagonal line, linear regression.
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PMC8494202
Moreover, we examined the expression of CKAP2L in normal human astrocytes and four different glioma cell lines, determining the highest CKAP2L expression in U251 cells (Figure 7(b)).
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PMC10440586
In GBM, CD99 is over-expressed mesenchymal and classical subtypes than that in proneural subtype , suggesting that it may be related to the PMT.
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PMC11786704
Energy-dispersive spectroscopy confirmed the homogeneous distribution of carbon and oxygen elements within the PC capsules, with negligible calcium content, indicating that the capsules were primarily composed of carbon and oxygen (Fig. 1E).
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PMC11781181
FTH1 is essential for maintaining iron homeostasis 38.
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PMC11486946
Source data are provided as a Source Data file.
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PMC11012012
Some SLAMF receptors have been demonstrated to possess prognostic significance.
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PMC11366496
Although RNF122 dysregulation and its biological role in several disorders have been reported before, , , its possible role in glioma remains unreported.
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PMC10454535
We sought to assess the combination’s effects on apoptosis induction in MM cells both cultured alone and co-cultured with BMSCs, using a Transwell model to mimic the bone marrow microenvironment.
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PMC7553912
Renal macrophages were recently reported to play an important role in the formation of crystal deposits.
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PMC11684269
However, once activated, the corresponding T cell subset undergoes metabolic reprogramming, which entails a rewiring from mitochondrial processes to glycolysis and glutaminolysis (9–11).
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PMC11656380
The structure of human NOTCH1 and the RAM13 domain: The top diagram illustrates the domain organization of human NOTCH1, including EGF (epidermal growth factor) repeats, LNR (LIN-12/NOTCH repeats), TM (transmembrane domain), NLS (nuclear localization signal), RAM (RBP-jκ associated molecule), ANK (ankyrin repeat), and TAD (transactivation domain).
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PMC11538390
We next engineered 701 bp DNA fragments including the ATAC-seq peak in HIOEC cells containing rs570516915 or rs556188853 and harboring either the risk-associated or non-risk associated allele of the SNP into a luciferase-based reporter vector (Supplementary Methods, Supplementary Fig. 5).
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PMC11092382
After intravenous injection, it is widely distributed in various tissues within the body, and thereby has protective effects on multiple organs.
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PMC11612794
To establish bipolar attachments of microtubules to sister chromatids, an inner kinetochore subcomplex, the constitutive centromere-associated network (CCAN), is assembled on centromeric chromatin and recruits the microtubule-binding subcomplex called the KMN network.
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PMC11585254
β-arrestins become activated when they interact with phosphates on the receptor, and the divergent functions may be linked to different activation states dependent upon discrete phosphorylation patterns along the CT (Nobles et al., 2011).
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PMC10873328
The TGFBI expression was increased with the increase of cisplatin concentration gradient, and downregulation of TGFBI could impair the chemoresistance of cisplatin-resistant ovarian cancer cells.
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PMC11543885
Different amounts of streptavidin beads (20, 60, 200 μL) were used for the pull-down experiments as indicated.
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