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OTAR3088
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BioData-CellLine_annotated

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PMC10158546
Prion seeding activity in ReN-PrP and ReN-PrP cells never surpassed ReN-PrP cells, which were included to account for signal from residual inoculum.
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PMC11767725
Pro-inflammatory adipokines and cytokines, including TNF-α and IL-6, activate key signaling pathways: NF-κB and JAK/STAT.
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PMC11607321
Unsupervised machine learning has been successful in multi-omics integration capturing patterns of data variation shared across different omics.
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PMC11634794
Similarly, research on prostate cancer revealed that Abrus agglutinin (AGG) induces lipophagy - a selective pathway involving autophagic breakdown of lipids - resulting in the production of free fatty acids (FFAs) and triggering senescence in PC3 cells.
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PMC11755467
The human immunodeficiency virus type 1 (HIV-1), the causative agent of AIDS, exhibits a leading account of infectious disease death especially in southern African countries.
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PMC9412887
Lastly, Pt-NPs and F-NPs were mixed to obtain the mixed nanoparticles (F-Pt-NPs).
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PMC11512230
These findings raise a debate about the use of PEG in clinical practice.
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PMC11682525
Preconditioned cells typically exhibit significantly improved survival rates, enhanced differentiation potential, augmented paracrine effects leading to increased trophic support, and superior homing abilities to lesion sites.
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PMC10335954
The carcinogenic role of the p53 signaling pathway has been shown in numerous studies, demonstrating that the loss of p53 function promotes the development of about 50% of human tumors (Lane and Levine 2010).
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PMC9429973
Results: 1.
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PMC11785489
Third, we analyzed crystal structures of αβTCRs complexed with class I MHC from the Protein Data Bank (PDB).
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PMC3888431
A simple metric was used to compare the different assemblies.
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PMC11612626
Fluorescent intensity was monitored as a direct measurement of substrate hydrolysis.
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PMC6461034
In the end, each “IP” tube should have received 20 μl beads.
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PMC11698348
Horseradish peroxidase tagged IgG antibodies were used as secondary antibodies (1:3000, ThermoFisher, UK, S1 Table in S1 Data).
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PMC7724160
Water with 0.1% formic acid and 98:2 acetonitrile:water with 0.1% formic acid were used for mobile phase A and B respectively.
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PMC11473843
-2A-GFP (PX458) (Addgene Plasmid #48138; https://www.addgene.org/48138/; RRID:Addgene_48138) was a gift from Feng Zhang (Ran et al, 2013).
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PMC9918897
For the statistical analysis, a two-way ANOVA test was performed (p < 0.05).
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PMC9429973
J. Y. Chen, L. Johnson, K. M. McKenna, T. S. Choi, J. Duan, D. Feng, J. M. Tsai, N. Garcia-Martin, K. Sompalli, R. Maute, P. Vyas, R. Majeti, C. H. M. Takimoto, J. Liu, G. Ramsingh, M. P. Chao, J.-P. Volkmer, I. L. Weissman Stanford University School of Medicine, Stanford; Gilead Sciences, Inc., Foster City; Brigham and Women’s Hospital, Boston, United States of America; Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom; Ludwig Cancer Center and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, United States of America Background: Magrolimab is a monoclonal antibody that blocks CD47, a “don’t eat me” signal expressed on cancer cells, to escape immune surveillance and macrophage-mediated clearance.
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PMC9429973
By colony-forming assay, we observed that ROS low and ROS high cells have similar colony-forming capacity, but only ROS low cells preserve this capacity after a second replating whereas the ROS high population does not (p=0.002).
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PMC9424261
Firstly, Crispr–Cas9 was used to construct cells that stably knocked out HERPUD1.
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PMC11772585
Total RNA was then isolated for qRT-PCR analysis.
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PMC3164356
To find evidence of multiple or duplicate chromosomes across the 22 sample preparations, we used the frequency of the paired-end reads aligning from each chromosome preparation to compute the correlation between the N50 scaffolds (Supplementary Notes).
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PMC9429973
Results: The randomized part of LOTIS-5 commenced in January 2022, and recruitment is ongoing.
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PMC6684588
Weight of uninjected rectus femoris muscle (ipsilateral to injected gastrocnemius muscle) and uninjected, contralateral rectus femoris muscle.
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PMC9429973
OS in the patients with MTV above the median (high, ≥141 ml) was significantly worse compared to the group with low MTV (<141 ml) (median OS 6.1 years versus 7.6 years; p=0.0077).
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PMC10728200
The red dots indicate the positive PLA signal.
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PMC10955424
The samples were analyzed by injecting 5 μL of the extracted solutions into a UHPLC connected to a photodiode array detector (Dionex Ultimate3000), with a reverse-phase column (ZORBAX Eclipse Plus C18, 100×3.0 mm, 1.8 μm).
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PMC11451940
The residue was suspended in pentane for 2 hours and reprecipitated with a CH2Cl2/petroleum ether (ca.
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PMC11802929
Accordingly, Pep-Groups occupied different regions on the Pep-UMAP (Fig. 3e, Supplementary Fig. 5b).
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PMC11684297
The excitation of the sample was done at 485 nm, and the emission was measured at 528 nm (the emission peak of the dye).
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PMC11588008
The viability of ovarian cancer cells in different groups. (
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PMC3931643
Our data suggest that reduced 4EBP expression might be a biomarker of resistance to asTORi and to dual PI3K/mTOR inhibitors in DLBCL and other blood cancers.
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PMC10237474
The DHFR-based system leads to high productivity which is a result of multiple rounds of MTX selection for cells that have increased copies of DHFR and the gene of interest.
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PMC3681794
A reduction of p53 phosphorylation at serine 15 was seen in hypoxia compared to normoxia following exposure to the DNA damaging agents.
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PMC11453018
Ewing sarcoma (ES) poses a significant therapeutic challenge due to the difficulty in targeting its main oncodriver, EWS::FLI1.
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PMC11805741
Additionally, the resonance-stabilized intermediate produced by this lengthy polyene chain allows for an effective quenching of reactive oxygen species (ROS) (Namitha and Negi 2010).
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PMC9429973
There were no fatal TEAEs.
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PMC11640419
homo-cyclomagnesiation of tetrahydropyran 5,6-heptadien-1-ol ether 1 with EtMgBr in the presence of the Cp2TiCl2 catalyst (5 mol%) to give magnesacyclopentane 2.
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PMC10812665
On the level of the whole organism (rats or humans), some differences may be easier to explain.
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PMC10170482
To determine cell proliferation dynamics, we stained the cells with the anti-Ki67 antibody and calculated the Ki-67 labeling index.
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PMC8750422
We also found that L-NAME treatment markedly abolished the effects of GPR87 overexpression, indicating that the inhibition of eNOS can inhibit GPR87-induced metastatic properties in lung adenocarcinoma.
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PMC7570809
The membrane was probed with the primary antibodies (anti pAKT (Ser473) or anti AKT (Cell Signaling Technologies, Boston, MA, USA)) over night at 4 °C.
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PMC11469524
Systematic perturbation data of bead-based ELISA measurements of the DLBCL cell lines HBL-1 and OCI-LY3 quantified as log2 fold changes to solvent control (DMSO); mean of n = 3. (
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PMC10852540
In some cases, even a change in EGFR levels alone may be sufficient to induce cancer development.
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PMC10237474
Importantly, the PB system also has demonstrated significantly higher transposition activity than other transposons such as hyperactive Sleeping Beauty and Tol2 .
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PMC11772449
There are four subtypes in mammals: p38α (MAPK14), β (MAPK11), γ (MAPK12) and δ (MAPK13).
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PMC10988808
C, D Representative immunoblots of biomarkers of proliferation and the Hippo pathway, using ACTIN as reference.
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PMC11529598
B. Apoptosis analysis was performed on miR-3154 sponge A172 cells and control A172 cells using flow cytometry.
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PMC10507284
Disease‐specific survival (DSS) also exhibited the same trend, although not statistically significant.
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PMC9429973
Six patients (28.6%) in the Chemo-DLI group developed grade II-IV acute graft-versus-host disease (aGVHD).
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PMC11607321
All datasets have been previously processed, normalized/scaled, and batch corrected in each of their individual publications addressing technical and design aspects important to each dataset (e.g., integration of CRISPR-Cas9 screens across different laboratories, driver mutations and copy number alterations, and gene expression samples from different datasets).
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PMC9318744
While novel vaccines provide protection and slow the spread of infection, this approach is not feasible in some immunocompromised individuals, and breakthrough infections in vaccinated and boosted individuals have been reported .
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PMC11036064
Also, hsa-miR-34a-5p significantly increases the anti-tumoral effect of temozolomide on A172 cell migration (Figure 8A(Fig.
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PMC10529414
All nonprimary alignments were removed from the SAM files using SAMtools, and the SAM files were converted to BAM format.
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PMC9429973
However, TLR-3, 9, RIG-I, MDA5, STING, MAVS, MYD88, and IRF-3, 7 were significantly inhibited by RAS/MAPK and RAS/MAPK-Aza.
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PMC11388384
In fact, the chordate-novel Hedgehog-binding protein SCUBE1 (Signal peptide, CUB domain and EGF like domain containing) catalytically accelerated transitions between confined and free populations, suggesting that SCUBE1 expanded Hedgehog gradients at least partly by modulating its ability to cross diffusion barriers.
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PMC10204952
Thus, in the current study, we evaluated how normal adipocyte-conditioned cell culture media (AD-CM) and cancer-associated adipocyte-conditioned cell culture media (CAA-CM) would affect high-concentration S1P treatment of triple-negative breast cancer (TNBC) cells.
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PMC11012012
In vitro exhausted CD8+ T cells showed increased degranulation when anti-human SLAMF6/CD352 was added to the culture.
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PMC7602170
Generally known, this tumor entity arises from the intestinal cells of Cajal (ICCs), a line similar to GI pacemaker cells, or multifunctional stem cells differentiating into ICCs .
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PMC11806182
These findings suggest that these genes may play critical roles in the progression and prognosis of UCEC.Fig.
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PMC11718809
A study on circ09863 in breast epithelial cells showed that overexpression of circ09863 significantly countered the inhibitory effect of miR-27a-3p on its target gene FASN, promoting FASN expression to regulate TAG synthesis and fatty acid composition .
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PMC11566417
All experiments were performed with both low and high passage cell cultures.
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PMC11388384
Indeed, in Drosophila wing discs, cytoneme length is positively correlated with HH signaling range (11).
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PMC11082662
Subsequent to trypsinization, 1,000 cells were seeded into 96-well plates and then subjected to the aforementioned transfection process.
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PMC11599565
The transcription of Snail (SNAI1) was upregulated upon cisplatin exposure.
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PMC4395774
The prognosis for FHL patients is poor with a median survival of less than 2 months after diagnosis if untreated.
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PMC11696576
For the ligand docking, a scaling factor of 0.8 and a partial charge cutoff of 0.15 were employed.
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PMC9872547
The apoptosis assay treated HeLa and fibroblast cells with curcumin (50 μM) and nano-curcumin (15 μM) according to the IC50 value.
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PMC11765988
Infectious mononucleosis (IM), increases the risk for HL, and the young age of infection elevates even more the relative risk .
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PMC11301242
Lina Wang: Resources, Investigation, Visualization.
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PMC11361748
We next performed bulk RNAseq analysis of WT and Krt17 null mouse ear tissue obtained at 6 h after a second TPA Tx to investigate TAR-related changes in gene expression.
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PMC10734950
Cancer can be linked to evading normal apoptotic mechanisms and causing dysregulated proliferation of cancer cells .
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PMC11463018
C20H15Cl2N5O2, [M + H] m/z: 432.06116, found: 432.06082.
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PMC11525293
Actin was used as the loading control; one representative experiment is shown.
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PMC8557138
Although several 3D model systems consisting of ECs alone have been successfully developed, their in vivo implantation has resulted in immature integration to the host vasculature leading to regression (Au et al. 2009).
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PMC11359735
Between 2.5 to 5 × 10 sporozoites were used for each experiment.
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PMC11701801
The OVISE (JCRB1043, RRID: CVCL_3116), OVTOKO (JCRB1048, RRID: CVCL_3117), RMG-I (JCRB0172, RRID: CVCL_1662), RMG-V (JCRB1729, RRID: CVCL_M716), KMRC-1 (JCRB1010, RRID: CVCL_2983), SW-13 (JCRB9069, RRID: CVCL_0542), and SBC-5 (JCRB0819, RRID: CVCL_1679) cell lines were obtained from the Japanese Collection of Research Bioresources Cell Bank.
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PMC9429973
We could not find differences in PFS according to N and EN presentations when controlling for other prognostic factors.
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PMC9428827
This change toward immunity reaches the tumor microenvironment, and it is mainly due to the specific increment in CD8 T-cell proliferation without any important change in Treg accumulation or activation.
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PMC11549612
Methylation analysis via the UALCAN database.
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PMC11653533
In particular, the root of the species is utilized in the local community for the treatment of reproductive diseases, arthritic conditions, elephant fever, diarrhea, leprosy, malarial fever, respiratory diseases, chicken pox, epilepsy, burns, and infections (Singh et al., 2012, Khan et al., 2011).
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PMC11644761
N. MN1020; dilution 1:50) to detect phosphorylated pSer202/Thr205 tau and Ki-67 (Invitrogen, Rockford, IL, USA, Cat.
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PMC10975211
The practical application of buforins as therapeutic agents faces challenges such as high production costs, limited bioavailability, and potential toxicity to mammalian cells.
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PMC11541409
41(16_suppl): p. e23508-e23508.This reference is of outstanding importance because it reports that THE-630 is a promising drug for GIST patients after imatinib failure and ≥1 TKI treatment.
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PMC11387401
J-Lat 10.6 cells were treated with AFF2, H4C9, and RPLP0 targeting ASOs.
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PMC11269792
Cells were cultured in DMEM (Gibco; Thermo Fisher Scientific) in a humidified incubator at 37 °C with 5 % CO2.
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PMC11568601
H&E staining was performed to obtain histological information.
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PMC10158546
As such, a comprehensive evaluation of the effects of PrP expression on the phenotype or function of ReN cells was beyond the scope of this study.
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PMC9429973
We further observed that under ibrutinib the percentage of expression of PD1 significantly decreased mainly in CD4 T-cells as compared to that seen in progressive CLL (Figure 1A).
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PMC11541409
42(16_suppl): p. 11518-11518.This reference is of importance because it reports that NB003 is a promising drug for GIST patients after imatinib failure.
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PMC8750422
LPA promoted AKT and eNOS phosphorylation, and silencing of GPR87 significantly reduced the increased phosphorylation of AKT and eNOS induced by LPA treatment (Figure 3d,e and Figure S3c).
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PMC10745221
Revertant cells of other methionine-addicted cancers have also been shown to lose their malignancy with their methionine dependence .
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PMC11021472
However, for a smaller subset of circRNAs, expression patterns were not associated with the expression patterns of their host genes.
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PMC11548041
Both PLD01 and PLD02 exhibited excellent serum stability, likely facilitated by the inclusion of phosphorothioate-modified bases within the aptamer sequences that conferred protection from endonucleases.
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PMC11754784
All DNA Sequences shown in Supplementary Table S4 were synthesized, modified and purified by Sangon Biotech Co. Inc. (Shanghai, China).
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PMC11225860
FUCCI cells treated with 500nM alisertib demonstrated G1 cell cycle slippage, failing to reenter G1 after division (Fig. 4a and Sup Fig. 4a).
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PMC11615218
A highly diverse baseline TCR repertoire is associated with favorable responses and improved survival outcomes in CAR-T cell therapy.
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PMC9429973
Compared with immunomodulatory drugs (IMiD) and other CELMoD agents, CC-99282 had similar immunostimulatory effects and 10- to 100-fold stronger antiproliferative and apoptotic activity in preclinical models of diffuse large B-cell lymphoma (DLBCL).
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PMC9918897
For the ABTS measurement, an aqueous solution of the ABTS compound was prepared at a concentration of 7 mM. This stock solution was reacted with 2.45 mM potassium persulphate and allowed to stand for 16 h in the dark at room temperature in order to develop the ABTS· stock solution.
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