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BioData-CellLine_annotated

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PMC9221284
Their activity allows proper B-cell differentiation and secretion of high affinity antibodies.
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PMC8345486
Originally, the OVCAR-3 cell line was derived from progressive ovarian adenocarcinoma.
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PMC11761919
mRNA levels of IFN-γ, IL-2 detect by real-time PCR (qRT-PCR).
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PMC9429973
Across all dose levels, 86.5% (n=32/37) of all responders achieved at least a very good partial response and 43.2% (n=16) of responders had a complete response (CR) or stringent CR.
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PMC11751675
Three enantiomeric sesquiterpene lactones—saluenolide A (43a) and its two dimers (43b and 43c)—were isolated from Senecio species, a widely distributed Chinese medicinal herb traditionally used for treating hepatitis B. The anti-HBV activity of these purified compounds was assessed, revealing that all three exhibited suppressive effects on the expression of HBsAg and HBV e antigen (HBeAg) in the HepG2.2.15 cell line.
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PMC5839394
Functional interaction network of AgNPs-EPS regulated proteins created by String algorithm.
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PMC9429973
One patient developed a new pleural effusion on the 200mg bd dose, which did not recur on dose reduction.
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PMC11656657
The gating strategy employed to identify GD2-positive cells in sarcoma patient biopsies is detailed in Supplemental Fig. 1A.
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PMC8864075
The “light” and “heavy” samples were combined and the desalination was performed by Pierce™ C18 Tips (Thermo Scientific,87782).
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PMC8998437
Almost all eBLs, along with the constitutively activated c-MYC oncogene, display the EBV latency I program expressing only one EBV latent protein EBNA1 from the Qp promoter (reviewed in ).
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PMC9429973
PTLD histological subtypes were 66 (76.7%) monomorphic, 18 (20.9%) polymorphic, and 2 (2.3%) early lesions.
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PMC10538569
GPI-scFv X5 protects CD4 T cells in cis but not in trans when displayed on CD8 T cells. (
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PMC7338939
Total RNA was extracted using TRIzol reagent (Invitrogen).
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PMC10154881
There are accumulating reports that NECTIN4 is a promising therapeutic target, because NECTIN4 expression arises in several cancers, and its expression is limited in a few normal tissues such as embryo and placenta. , , , , , ,
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PMC5417661
Moreover, the OvCar-4 cells were more sensitive to 12.5 nM of paclitaxel at 48 and 72 h time points when compared to same concentration of NOV202 (Figure 2B).
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PMC6182045
Standard amine coupling methods were used to couple anti-human Fc to a CM5 sensor chip.
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PMC9429973
With a median follow-up (f/u) of 13 months, the median OS was 7.6 months in R/R cohort.
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PMC11078693
This staining will increase background in the wide-field fluorescence imaging, but not in confocal microscopy.
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PMC9429973
Whole-blood thromboelastometry (ROTEM) depicts diverse aspects of coagulation including hyper-fibrinolysis and captures the influence of erythrocytes, leucocytes and platelets to hemostasis, which might contribute to BUC.
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PMC6892818
mCD40L induced phosphorylation of both MKK4 and MKK7, as well as triggering sustained phosphorylation of downstream target JNK (Fig. 6a).Fig.
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PMC9429973
Prior to the REALITY study, limited data were available on the effectiveness of ibrutinib-treated pts with CLL in routine clinical practice in Germany.
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PMC7685376
One week after injection, Huaier (100 μL of solution containing 50 mg) was administered via gavage daily for 35 days.
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PMC9878562
We next measured the release of LTB4 by VAL-wt and VAL-ko cells.
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PMC11366496
Lys48‐linked ubiquitination mediates substrate degradation via the proteasome pathway, accounting for half of all ubiquitination forms.
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PMC9429973
Pts were screened for DNA changes by using a custom designed NGS panel with 19 genes related to DBA (RPS19, RPL11, RPL15, RPL18, RPL27, RPL31, RPL35, RPL35A, RPL5, RPS10, RPS15A, RPS24, RPS26, RPS27, RPS28, RPS29, RPS7, TSR2 and GATA1).
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PMC11194678
The supernatant was isolated from the pellet into a clean tube immediately after centrifugation.
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PMC9429973
1 patient is currently in CR and waiting for transplant (MPS secondary AML).
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PMC11759751
CD19-CAR was detected by incubating cells with APC-F(ab′)2 (Jackson ImmunoResearch, USA).
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PMC11247842
Under the gene track, the black color block indicates the GC CNV.
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PMC11539788
Here, we identified a previously unreported tumour suppressor function of RNF19A in BCa.
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PMC11655498
Epstein-Barr virus reactivation is subject to multiple layers of regulation after initiation. (
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PMC8662250
Considering the well‐established “gate‐keeper” properties of CBD due to its ability to rescue RhoA GTPase (Gigli et al., 2017), we proposed it as a possible molecule able to downregulate NLRP3/Caspase‐1/IL‐1β and IL‐18 pathway.
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PMC10969097
Traditional Chinese medicine has recognised the importance of mushrooms for many years, considering them an alternative for cancer treatment due to their properties and low toxicity .
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PMC11650848
During this study, the theta band power remained the same while the beta band power increased linearly .
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PMC9841531
In short, MCT1-expressing A-549 cells were exposed to the MCT1 substrate 3-BP, which becomes influxed by MCT1.
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PMC6889484
Additionally, reverse transcription inhibitor 3′-azido-3′-deoxythymidine (AZT; 4 μM, final concentration, Sigma, St. Louis, MO, USA) was added to culture media to block potential reinfection of the producer cells.
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PMC11499381
cAMP values were interpolated from a standard curve that was included in each experiment.
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PMC10898159
In addition, the study of how TF linked to essential chromatin regulators will also provide important insights into the gene regulation and epigenetic mechanisms of GIST .
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PMC11488203
This enables an enhanced formation of tetraspanin-enriched microdomains that contribute to a functional crosstalk among signaling pathways of targeted cells.
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PMC11474209
Cyanotoxin exposure is a major contributor to the disease development process.
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PMC9429973
Several therapeutic approaches have been tested in this subset of patients with poor clinical results.
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PMC10114490
Red line marks FDR = 0.05.
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PMC11767817
Thus, an analysis of oxidative stress generation by the curcumin derivatives was performed (Figure S6).
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PMC11627398
Additionally, research indicates that the occurrence of infectious diseases, including septic shock, COVID-19 and influenza, is closely linked to the host’s immune response, which encompasses both innate and adaptive immune systems [78–81].
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PMC11762280
We proceeded to investigate the role of MLKL-mediated necroptosis of keratinocytes in UVB injury.
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PMC9143157
For example, recently squalene that is a triterpene in the cholesterol biosynthesis pathway widely distributed in nature, has been successfully developed as a nanoplatform for various therapeutic molecules and nucleoside analogues with gemcitabine, as well as doxorubicin and paclitaxel, and the the squalenoylated doxorubicin nanoassemblies exhibited much improved anticancer therapeutic efficacy with decreased cytotoxicity .
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PMC10631132
A-L Representative images of 3 replicates show PBMC-derived iPSCs (A-F) or fibroblast-derived iPSCs (G-L) differentiated according to either an embryoid body-based (EB) protocol (A, B, C, G, H, I) or a monolayer-based (MB) protocol (D, E, F, J, K, L) and stained for ectodermal (A, D, G, J), mesodermal (B, E, H, K), and endodermal markers (C, F, I, L).
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PMC2777936
The EC cells examined here respond in a similar way to murine embryos in which Wnt signalling is not evident until day 6.5 when reporter activity is seen at the posterior of the embryo where the primitive streak begins to form .
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PMC10114490
Hepatocytes were seeded on fibronectin/collagen-type I-coated (Sigma-Aldrich, Madrid, Spain) dishes and cultured with Ham’s F-12/Williams (1:1) medium (Gibco BRL, Paisley, Scotland).
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PMC10858941
Mycoplasma positive cells were discarded or treated with Plasmocin (InvivoGen, California, USA; ant-mpt-1).
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PMC6461034
This score rewards high‐ranking kinases that are targeted by predominantly high‐affinity drugs while penalizing kinases associated with low‐affinity drugs.
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PMC11640476
The A549 cell line has become a cornerstone in biomedical research, particularly in cancer studies and serves as a critical tool in cytotoxicity studies and drug screening where it is used to evaluate the impact of pharmaceutical compounds on cellular viability.
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PMC11752767
These cells promote inflammatory signals as soon as the immune system recognizes the growing tumor in tissue.
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PMC9503685
Aliquots of the resulting suspensions were removed from the wells and plated on TSA, after making the necessary dilutions.
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PMC10734950
The controls that were included are the same as previously stated.
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PMC10218459
Our investigations showed that all cytostatics led to a significant reduction in cell viability.
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PMC11738017
Furthermore, the weak correlation between sBCMA and the degree of bone marrow plasmacytosis reflects the disease spatial heterogeneity and the need for more accurate tools to evaluate disease burden.
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PMC9429973
The PFS and OS in our cohort was lower despite majority of patients achieving early CR per iPET.
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PMC9952933
CAP also induced growth inhibition in bone sarcoma cells, the stimulation of cell apoptosis, and the impairment of cell membrane functions .
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PMC10772747
The results in Figure 2C, D showed a significant effect on the cell cycle distribution treated with EBE (P < 0.0001).
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PMC8956657
For the NF-κB promoter luciferase assay, HEK293T cells (7.5 × 10 cells/well) were transfected with 30 ng of the NF-κB firefly luciferase reporter, 30 ng of a constitutively expressed Renilla luciferase reporter (pRLTK), and Flag-tagged MERS ORF4b and mutants (25 ng and 2.5 ng), using Lipofectamine 2000 (Thermo Fisher Scientific).
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PMC11678841
Overall, our data indicate that GA holds potential for restoring the immuno-metabolic properties of the vaginal epithelium exposed to C. albicans infection, which may help to treat inflammatory symptoms in VVC/RVVC.C. albicans is both a significant component of the human mycobiota and the primary fungal pathogen worldwide leading to a wide range of diseases, from mild mucosal infections to severe systemic candidiasis, particularly in immunocompromised patients .
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PMC11592837
The DNA integrity index was calculated as the ratio of long to short fragments (Alu 247/Alu 115 and MTCO3 296/MTCO3 67).
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PMC11774112
The data in D are expressed as the means ± SDs (n= 6). (
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PMC9429973
SCFAs concentration were measured by LC-MS in an LC-ESI-QQQ 8030 (Shimadzu) instrument after acetonitrile precipitation and derivatization.
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PMC9429973
Results: The proportion of RBC containing one or more fluorescent dots by IFC correlated with results of the conventional method, i.e., the operator-dependent quantification of pocked RBC by differential interference contrast microscopy.
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PMC9429973
N. Romanenko Clinical of Hematology, Russian Research Institute of Hematology and Transfusiology, Saint-Petersburg, Russia Background: The central vascular access needs to provide a large volume of infusion therapy, including transfusions of blood, long term infusion of immunotherapy and chemotherapy in oncohematological patients (OHP).
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PMC11472569
Jaiswal et al. found that the MDR phenotype acquired by recipient cells remained stable for at least 5 days in vitro, even in the absence of selecting pressure.
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PMC9429973
Methods: OMNIVERSE (NCT04887857) is a multicenter, open-label, 2-part phase 1b trial (Figure).
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PMC9429973
Moreover, in vitro supplementation of MDSCs in murine or human lymphoma culture increases the expression of mrp1, pgp and cellular GSH level from early passage than passage without MDSCs, which is correlated well with in vitro drug retention and generation of drug resistance phenotypes and tumor progression.
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PMC9792775
In addition, as ultrasound acts locally on the tumor, it can minimize damage to the surrounding normal tissues (Xia et al., 2012; Sadeghi-Naini et al., 2013).
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PMC11186948
Nuclei and total lysate were extracted as reported below and centrifuged at maximum speed for 10 min at 4 °C for removing debris.
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PMC10212663
Univariate and multivariate analyses on PFS, OS, and DSS (a)–(c) were conducted, respectively, to further confirm the prognostic role of RANKL in advanced KRAS‐mt patients.
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PMC11736898
Immunohistochemistry was performed using a rabbit anti-CYP24A1 polyclonal antibody (Catalog #21582-1-AP; Proteintech Group Inc., Rosemont, IL) diluted 1:200 and incubated with sections for 16 h at 4°C.
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PMC10329074
Six fields of view were randomly selected from each membrane, and the cells were counted under a microscope.
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PMC11087301
Deregulation in calcium homeostasis is able to increase tumor invasion and migration by inducing EMT through multiple mechanisms such as extracellular matrix remodeling, invasion and integrin interplay.
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PMC5839394
In particular, SKBR3 cells proliferation was significantly inhibited by AgNPs-EPS with an IC50 value of 5 μg/ml, while an IC50 value of 8 μg/ml was found for 8701-BC cell line.
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PMC4659567
However, all the studied complexes 1–8 were found to be inactive up to the highest tested concentration (IC50 > 50.0 μM).
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PMC8316344
NS non-significance; **P < 0.01; ***P < 0.001; ****P < 0.0001.
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PMC10758402
In this study, we examined the effects of DMF and various FMAEs on oncolytic HSV-1 in the context of cancer.
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PMC11754432
Antibody details are available in Table S1.
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PMC11547917
The difference between cytotoxic activities of Aristolochia sp. extracts can be explained by several parameters: the specific particularities of the Aristolochia plants; the part of the plant used in the study; the different composition of extracts due to the use of different aqueous or organic solvents; the type of extraction; and the particular features of the cancer cell line.
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PMC11680982
In stark contrast, the noteworthy DESTINY-Breast 04 study unveiled an impressive ORR of 52.6% using the innovative ADC agent T-DXd in HR/HER2-low breast cancer.
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PMC9429973
Summary/Conclusion: Aberrant methylation of oncosuppressive microRNA genes associated with underlying p53 signaling pathways is a potentially useful molecular biomarker in the diagnosis, prognosis of tumors and the development of a strategy for targeted therapy of DLBCL.
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PMC11708541
After the SLE, pyramidal neurons were active with varying delays.
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PMC9429973
Presence of NPM1 mutation was associated with reduced viability after treatment with EHOP-16 (p=0.025), ITX3 (p=0.047) and NSC23766 (p=0.005).
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PMC10237474
The titers of HEK293S GnTI stable pools are higher than those reported previously , but are generally 1.3-10-fold lower than those of Expi293F GnTI stable pools.
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PMC8978939
Panel III presented tumor infiltrating the neighboring striated muscle, and the asterisks (*) indicate traces of tumor progression between the muscle bundles.
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PMC7840816
p < 0.05.
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PMC10999934
To our knowledge, the “Scissor” algorithm is the first bioinformatics tool that automatically identifies the most phenotype-relevant cell subpopulations from a single-cell dataset by leveraging a bulk dataset and phenotype information.
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PMC8481254
These data suggest that changes in increasing concentrations of glucose and CA treatment of YAP are independent of the Hippo pathway.
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PMC11538390
Statistical significance is determined by Student’s t test.
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PMC11344246
Structure-based drug discovery methods have been shown to lead to more efficient, specific, and rapid progression to clinical trials from protein target discovery (47).
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PMC10545062
The median animal weight between groups was equivalent (SCC: 70.4 kg vs. SCC+: 73.3 kg, p = 0.52).
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PMC11764090
Crop yields are negatively affected by cold stress, including chilling (0~12 °C) and freezing stress (≤0 °C) resulting in constrained sowing time, damage to plant tissues, and stunted plant growth .
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PMC9503669
HIV-1 is an integrating lentivirus that directly targets the adaptive immune system, making the development of curative strategies very challenging.
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PMC11700165
Unexpectedly, we found that ITK-SYK has the unique capacity to translocate to the nucleus upon activation.
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PMC9429973
The study is conducted at approximately 25 sites located in Italy and it will enroll up to 80 patients in the midostaurin-treated cohort and up to 50 patients in the midostaurin-not treated cohort.
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PMC11730320
Final Extension was set at 68 °C for 5 min, and then lowered to 10 °C indefinitely.
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PMC3035438
Moreover, given the ease of genetic manipulation and culture of DT40 cells (10), the selected clones can be readily expanded and manipulated to accommodate the needs for a scaled-up production or an improved immunoreactivity, including, for instance, the development of in vitro affinity maturation systems based on the genetic enhancement of Ig hypermutation (11,12).
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