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PMC9429973
R. Sun, Q. Sun, F. Zhang, X. Cui College of Traditional Chinses Medicine, Shandong University of Traditional Chinses Medicine; The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China Background: Multiple myeloma (MM)is a common hematological malignant tumor disease.
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PMC11279397
Moreover, Eugenol has been documented to exhibit antiviral activity against tomato yellow leaf curl virus (TYLCV) , tomato yellow leaf curl Thailand virus (TYLCTHV) , human norovirus, tobacco mosaic virus (TMV) , HCV , and Feline Calicivirus (FCV) .
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PMC9429973
Immunophenotypic analysis of CAR T cells revealed a central memory phenotype (CD45RO+/CD45RA-/CCR7+), (>99% cells).
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PMC8345486
A parallel process of acquiring cell resistance to chemotherapeutic agents has also been observed in cell cultures.
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PMC11779960
Illustrations for Fig. 1 were done with BioRender (https://BioRender.com).
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PMC11604768
Candidate barcodes were clustered within each sample via Starcode using a Levenshtein distance of one (starcode -i input_file.tsv --print-clusters -s -d 1 -o output_file.tsv).
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PMC11323699
Subsequently, mice were sequentially treated with TAX2 until the end of the protocol (IV, three times a week at 30 mg/kg).
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PMC11459296
Murine PB was then monitored weekly by flow cytometry to follow the CB-MNC-derived immune cell populations.
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PMC9429973
S. Bohlscheid, G. Filippini Velazquez, H. Aslan, T. Baudrexler, H. Schmetzer, C. Schmid Medical Department III, Department for Hematopoietic Cell Transplantation, Munich University Hospital, Munich; Department of Hematology and Oncology, Section for Stem Cell Transplantation, Augsburg University Hospital, Augsburg, Germany Background: Upregulation of inhibitory checkpoint molecules (ICM) on T-cells and their ligands on leukemic blasts may be a mechanism of acute myeloid leukaemia (AML) relapse after allogeneic stem cell transplantation (SCT).
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PMC11694346
These results suggest that BT-DNBS may serve as a valuable tool for imaging biothiol fluctuations in live cells, with potential applications in disease diagnostics and studies of cellular redox biology.
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PMC11534035
Treating A431 cells with G36 (Figure 1B) caused a visible increase in PAI1 expression in the Western blots.
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PMC11519077
NOD1 and NOD2, as two members of the NBS/LRR family of proteins, are suggested to be cytoplasmic “sensors” of microbial products .
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PMC10968586
In neuroblastoma cells T98G, 277.5 μM and 555 μM OLE showed a synergistic effect with alkylating agent temozolomide on cell viability, increasing the expression of miRNAs involved in tumor growth suppression, mainly Let-7d .
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PMC9429973
T. Trab, J. Baech, L. Hjort Jakobsen, S. Husby, M. Tang Severinsen, S. Eloranta, J. S. Gørløv, J. M. Jørgensen, S. Gudbrandsdottir, T. Stauffer Larsen, P. Brown, K. E. Smedby, T. Christoffer El-Galaly Department of Hematology, Clinical Cancer Research Center, Aalborg University Hospital; Department of Clinical Medicine, Aalborg University, Aalborg; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Medicine Solna, Division of Clinical Epidemiology, Karolinska Institutet, Stockholm, Sweden; Department of Hematology, Aarhus University Hospital, Aarhus; Department of Hematology, Zealand University Hospital, Roskilde; Department of Hematology, Odense University Hospital, Odense, Denmark Background: High-dose chemotherapy (HDT) with autologous stem cell transplant (ASCT) have resulted in more long-term lymphoma survivors.
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PMC11395280
Given the improved survival of the CCL198-83 treated T-ALL mice, clinically, CCL198-83 has potential as a prophylactic treatment for pediatric T-ALL patients, keeping T-ALL cells and possibly other diseased T-cells in the periphery where they can be killed by effective chemotherapies.
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PMC11087301
For instance, histone deacetylase inhibitors (e.g., entinostat) were able to suppress formation of VM structures in a some cancer models .
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PMC11224020
Mice were maintained under specific pathogen-free conditions at the animal facility of Institut Curie, in accordance with institutional guidelines, and housed in a 12-h light/12-h dark environment with free access to water (osmotic water) and food (MUCEDOLA, 4RF25SV Aliment Pellets 8 × 16 mm irradiated 2.5 Mrad and DietGel Recovery, 2 oz/DietGel Boost, 2 oz).
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PMC11300639
After 24 h of incubation, the cells were stained with 0.1% crystal violet for 30 min, and the unmigrated cells in the upper chamber were carefully removed with cotton swabs.
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PMC11269792
However, no studies have demonstrated its actions in GIST.
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PMC11640247
Active variants of small GTPases are generally classified into two types: GTPase-deficient variants and fast-cycling variants, the latter characterized by an increased intrinsic GDP/GTP exchange rate.
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PMC11283030
The primer sequences for ACLY were as follows: forward: 5′-CTATCAGGAGGGCTTACGGG-3′, and reverse: 5′-GAGGAAGTTTGCAGTGTGGG-3′. The primer sequences for GAPDH were as follows: forward: 5′-CAGGAGGCATTGCTGATGAT-3′, reverse: 5′-GAAGGCTGGGGCTCATTT-3′. The IHC analysis was performed on the tissue microarray (n = 145) as described previously .
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PMC4369959
In vitro studies showed that ginger has a promising anticancer activity against cholangiocarcinoma.
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PMC11770199
However, in the immunocompetent mouse models of breast cancer and lung cancer, the therapitic benefit from this modification was not as significant as it was in vitro.
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PMC11422497
Cell counting kit-8 (CCK8) and (B) RT-qPCR and (C) Western-blot assay showed the effects of circ_SMA4/miR-494-3p/KIT axis on cell proliferation and KIT mRNA and protein expression in GISTs. (
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PMC9429973
Image: Summary/Conclusion: This SLR demonstrated that patients with NTDT experience poor clinical and HRQoL outcomes and have significantly worse HRQoL than patients with TDT; however, the limited literature identified provide an incomplete picture.
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PMC11737091
The MCM proteins were phosphorylated by DBF4/CDC7 kinase, and then GINS and CDC45 bind to the phosphorylated proteins .
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PMC11585254
Statistical analysis was performed using GraphPad Prism 10.3.1 for macOS, GraphPad Software, www.graphpad.com.
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PMC11782508
Staphylococcus aureus (ATCC 25923), (b)Bacillus subtilis (ATCC 6633), (c)Escherichia coli (ATCC 8739), and (d)Klebsiella pneumoniae (ATCC 13883).
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PMC9429973
Patient characteristics and transplantation modalities between the 2 periods were comparable.
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PMC9429973
The outcomes assessed include length of stay (LOS), total charges, co-morbidity score, mortality rate and emergency room visits.
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PMC11541241
Yu et al. (2014) first identified and characterized nine pivotal components of the TOR signalling pathway in F. graminearum and further investigated their biological, genetic, and biochemical functions.
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PMC11471176
Gentle agitation was employed for thorough mixing.
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PMC11321678
Glutamatergic neurons arise from rhombic lip (RL) region.
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PMC11001582
Importantly, levels of polyGR in (GR)400 mouse cortex were similar to C9ALS/FTD patient cortex (Extended Data Fig. 2b), confirming expression in the physiological range.
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PMC11453018
iP300w was prepared in DMSO (10 mM), diluted in 100 µL PBS, and administered intraperitoneally twice daily, with the control group receiving the vehicle only.
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PMC11577421
Quantification of cell death in HeLa cells exposed to PCX-loaded NPs (NP_BSA/PCX and NP_BSA+/PCX) and control NPs (NP_BSA and NP_BSA+).
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PMC8524093
By the way, infection of this tissue is the key step to make the mosquito a competent vector, since the transmission occurs when it salivates during blood feeding and the released saliva contains infectious CHIKV particles.
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PMC8193046
They have extensively been used within the past 20 years.
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PMC6799808
β-Tubulin served as a loading control Cell cycle progression is tightly regulated by the coordinated activities of cyclin/CDK complexes, CDK inhibitors and Cdc25.
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PMC9429973
In comparison, an increase in sBCMA was observed in non-responders at C2D1 EOI, with the pts who had PD having the greatest increase (median: 93.14%).
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PMC11787381
Time of sampling: 1 h post-dosing.
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PMC10873328
Figure 6A model of the role of TGFBI in chemoresistance.
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PMC10344560
We chose to administer voriconazole as the alternative treatment after an assumption of a fluconazole-resistant state.
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PMC5035325
EGFR-positive section (green).
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PMC11461874
The cell lysates were immunoprecipitated by using anti-Flag antibody and then immunoprecipitates were subjected to immunoblotting.
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PMC11742231
This study focuses on the impact of multi-channel attention on the performance of the model.
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PMC11766309
Future research should aim to validate these findings in additional cancer types and in vivo models.
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PMC9712534
Cleared lysates were subjected to SDS-PAGE followed by electrotransfer to a PVDF membrane according to standard procedures.
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PMC11765243
Briefly, CD4CD62L T lymphocytes were isolated from spleen cell suspensions using the CD4 T-cell isolation kit II (130-090-860, Miltenyi Biotech, Bergisch Gladbach, Germany).
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PMC9429973
Lower grade GVHD had no statistically significant association with NRM.
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PMC11607321
Duplicated drug names represent replicated screens for the same drug.
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PMC3765139
The corresponding mean fluorescence intensities (MFI values) are attached as additional file (see Additional file 1).
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PMC11640115
A total of 54 patients were enrolled (Table 2).
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PMC11604015
However, it can cause profound complications such as graft versus host disease (GvHD), and the OS after HSCT is not satisfactory.
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PMC9429973
There was no difference in the 30-days survival between the two groups(p=0.832)(Figure 1).
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PMC11742231
This finding underscores the importance of incorporating attention mechanisms in deep learning models to selectively weight the importance of different channels and improve the model’s performance.
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PMC11566417
0.2% NaCl was added to the pellet for 10 s to lyse red blood cells.
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PMC11758416
Technical questions on executing this protocol should be directed to and will be answered by the technical contact, Kathryne E. Marks (kemarks@bwh.harvard.edu).
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PMC11397654
Increased levels of proline were proven to delay cell aging , and chiral proline-modified calixarenes have shown enantioselective inhibition of the formation of L1-p, a pentamer essential in the human papillomavirus (HPV) virion particle assembly .
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PMC11721295
While these are exciting developments, the prospect of resistance to targeted therapy is real; resistance already has been described for G12C inhibitors (4), with some instances involving sotorasib linked to the remodeling of the tumor microenvironment (5, 6).
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PMC11733919
In our experimental conditions, MNP@CD26@17D treatment affected glutathione redox potential as judged by the increased oxidation status of the redox sensor Grx1-GFP (Figure 5a), suggesting a pro-oxidant shift in the glutathione redox state and the accumulation of the oxidized form of glutathione GSSG, affecting the functionality of GPX4.
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PMC7709199
The crystal belonged to the monoclinic space group C2, with unit-cell parameters a = 78.6, b = 71.4, c = 92.2 Å, β = 113.1°.
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PMC10674574
However, Lee and al. showed that a transport buffer with a pH of 7.4 is a good qualitative predictor for physiological intestinal permeability from the duodenum to the colon .
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PMC10812665
Moreover, cytoskeleton-related proteins (e.g., kinesins) ranked high among the up-regulated genes identified here.
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PMC10530622
However, there are emerging pharmacological approaches that aim to reduce the endogenous production of oxalate.
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PMC9370419
Estradiol benzoate suppressed HBV replication and transcription in the cellular model of the HBV replication using HepG2.2.15 cells and HepG2 transfected cells.
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PMC11269792
As demonstrated in Fig. 7A-C, ablating circAPP suppressed GIST tumor volume and weight.
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PMC9220170
However, neither SELENOM-KD nor SELENOT-KD led to significant changes in the proliferative properties of A-172 cells under conditions of ER stress.
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PMC11499381
As well characterized heterodimers, these receptors were chosen as models to investigate the positional effect of fluorescent protein fusion in BiFC experiments.
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PMC11352746
It is preferred over animal models because of its high-throughput screening compliance, disease modeling feasibility, and the physiological relevance of human-derived neuronal culture .
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PMC11088135
Flow cytometry results showed that downregulation of lncRNA NUTM2A-AS1 significantly increased the apoptosis of U521 cells (Fig. 3E, F).
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PMC11365427
After centrifugation, the supernatant was mixed with loading buffer and boiled for 10 min.
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PMC11627060
The Dulbecco Modified Eagle’s Medium, fetal bovine serum, penicillin, and streptomycin were obtained from Hyclone (Logan, USA).
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PMC11711063
Furthermore, Bex + Carv‐induced basal characteristics, marked by elevated keratins 14 and 16, were abrogated by ZG16B (Figure S6).
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PMC11675244
Around 15% of sporadic colon cancers have showed mutations in the β-catenin gene that make it resistant to degradation, leading to constitutive pathway activation.
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PMC11590870
According to what has been reported in various studies, peptides with anticancer potential are mainly those that have antioxidant and antiproliferative activity .
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PMC8956657
The protein was then passed through a 5 ml GSTrap FF column to remove GST, and the unbound protein complex was concentrated to 10–20 mg/ml using 10 kDa MW centrifuge filters, aliquoted, and flash-frozen in liquid nitrogen and stored at −80 °C.
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PMC7185206
Future studies of products of proteolytic PD-L1 cleavage – including whether ADAM10 and ADAM17 cleave PD-L1 at the same sites and whether all products exhibit similar activities – are warranted.
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PMC11615828
Moreover, due to the irreversibility of CID, a transient rapamycin treatment (5 min) is sufficient to maintain vesicle immobilization for at least 24 h (Figure S7 and Video S7, Supporting Information).
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PMC4360730
Terms in Uberon include relevant cross-references to key model organism anatomy ontologies, such as the Drosophila gross anatomy (FBbt) and the C. elegans gross anatomy (WBbt) (12, 13).
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PMC11672881
The A375 cells were seeded at a density of 3 × 10⁶ cells per 10 cm culture plate (n = 3) and cultured overnight in DMEM supplemented with dialyzed FBS.
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PMC6889484
Distinct Vif-A3G and Vif-A3F interactions are necessary for inducing degradation of the A3 proteins, indicating that multiple Vif mutations may be required to overcome different Vif-resistant A3 proteins.
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PMC7709199
Refinement steps were performed with REFMAC5 (Murshudov et al., 2011 ▸) with a randomly selected 5% of reflections used for cross-validation.
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PMC10958426
Pearson's correlation coefficient between the expression level of a gene and the CNV level of the gene located region cross all cells was calculated.
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PMC4839679
Reexpression of PBRM1 also caused a significant inhibition of cell migration in an in vitro scratch test (Fig 6C), further validating PBRM1 in the regulation of cell adhesion and the maintenance of a more epithelial cell state. (
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PMC11295144
The synaptic contacts were labeled with presynaptic active zone marker Bassoon-specific antibody (MA1-20689, Thermo Fischer).
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PMC11607638
Therefore, SK and SKR regulate food intake in species such as Gryllus bimaculatus, Tribolium castaneum, and Tenebrio molitor, , downregulated expression of SK and their receptors all led to increases in food consumption.
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PMC11463018
After the reaction was completed, the mixture was allowed to cool and extracted with EtOAc/H2O (1: 1) system.
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PMC9621239
Considering that the liver is the only organ known to support HBV replication, studies on the characteristics of HBV QS in the liver during the progression of HBV-related liver diseases could better reflect the changes in the liver microenvironment.
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PMC3019555
The majority of solid tumors contain regions of hypoxia as a result of their poor local vasculature (Pouysségur et al., 2006).
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PMC11706491
Using the same experimental setup as with the wild-type strain, analysis of asynchronous cultures through time-lapse experiments, capturing images every 3 min over a period of 10 h (Figs 4B–4D and S4C and S5 and S6 Movies), revealed no major changes in the length of the cell cycle or in the distribution of the different phases.
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PMC11380454
This effect is significantly potentiated by cotreatment with anti-PD-1 antibodies in an additive manner.
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PMC11657695
KCNA1 and KCNA4 are mainly expressed in brain tissues, KCNA7 is expressed only in skeletal muscle, KCNA3 appears to be ubiquitously expressed whereas KCNA10 is not expressed in any healthy tissue, and KCNA5 is mainly found in artery and brain tissues (Figures S2A-S2F).
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PMC5035325
Similar intensity of NeuGcGM3 ganglioside expression with plasmatic membrane and cytoplasm staining was observed in 71 (77 %).
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PMC8584666
However, the growth of GPI-80 gene-deleted cells (#22ΔGPI-80) was lower than that of both PC3 and #22mock cells (Figure 3b).
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PMC11566417
Selection for G418-resistant cells was initiated after 24 h by supplementing EpSC medium with 700 µg/mL G418.
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PMC6889484
Virion incorporation of A33G-D128K-P2A or the reconstituted A3G-D128K-P2A could not be detected because of low levels of virion incorporation and sensitivity of detection.
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PMC10748106
Genipin had a higher value for this descriptor (64.589 Å) compared to the others (ranging from 26.808 to 46.922 Å).
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PMC7602170
However, MRI may be less reliable due to its difficulty in reproducible measurements of the signal intensity (SI) change, and thereby cannot be considered as the primary standard for therapeutic response assessment in GIST patients .
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PMC11682224
In a mouse glioma model, the combined treatment of HIF-1α inhibitors and anti-PD-L1 antibodies showed a more pronounced inhibitory effect on tumor growth compared to any single-agent treatment.
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