OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC10631132	Isoform 5b has been found to be predominantly secreted by OCs and could be used to further define mononuclear cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Isoform", "5b", "has", ...
PMC11721064	From this comprehensive collection, we selected pathways relevant to our specific research question for input into GSEA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "this", "comprehensive", "collection"...
PMC11519583	Proliferation of MPs in TA muscles injected with either Ctx or glycerol was analyzed (g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proliferation", "of", "MPs", "in", "TA", "m...
PMC11388384	The incubation chamber maintained a humidified 37 °C atmosphere with 5% CO2 and the objective was similarly heated to 37 °C for live-cell experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Warsaw, Poland; IQVIA, Falls Church, United States of America Background: Patients with lymphoid malignancies are at particularly high risk of developing secondary immunodeficiencies (SID).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11682172	The role of the immune system in tumorigenesis is complex and to some extent contradictory.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role", "of", "the", "immune", "system", "in", ...
PMC11551844	It is used in the US for the treatment of many solid tumors such as breast cancer, non-small-cell lung cancer and pancreatic cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11502327	Unfortunately, more than half of the patients will relapse after treatment and develop platinum drug resistance, which poses no small challenge to the chemical treatment of OC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6835428	They also have a low “fusogenicity” attitude, i.e., they are less effective in interacting with cell membranes to allow cell uptake.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11237030	4ʹ, 6- diamidino-2-phenylindole (DAPI) (Invitrogen) was added to visualize the nuclei.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4ʹ", ",", "6-", "diamidino-2-phenylindole", "(", "DAPI...
PMC11721064	p < 0.05, p < 0.01, *p < 0.001 Limbal niche facilitated the transdifferentiation of keratinocyte progenitor cells into corneal epithelial cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Patients received oral ciprofloxacin (500 mg daily on Day 3-13) to prevent bacterial infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "received", "oral", "ciprofloxaci...
PMC10847511	However, given intratumor heterogeneity, when attempting to establish cancer cell lines from tumors with HRD, slow-growing cells may be eliminated and fast-growing cells with highly enhanced alternative mechanisms may be selected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	MOE default settings for a brief simulation of 1 ns were employed, with a timestep of 2 fs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MOE", "default", "settings", "for...
PMC11746942	The knockdown of S1PR3 corroborated these findings and significantly impaired IL-6-induced STAT3 activation and K17 expression (Fig. 4F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "knockdown", "of", ...
PMC3730428	In this study, we demonstrate that SAHA sensitizes MPM cells to SMCs in a manner dependent on its ability to downregulate FLIP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11512230	Structurally modified plant viruses hold great potential and offer a number of unique advantages since plant viruses are not capable of infecting human cells and are biocompatible with low-cost production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8526701	Scale bar: 100 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "100", "μm", "." ] } ]
PMC9429973	However, the functional impact of such mutations in the hematopoietic system and MDS have been scarcely studied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "functional", "i...
PMC11724582	This result was consistent with the results of previous qPCR and survival analyses (Fig. 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "result", "was", "consistent", "with", ...
PMC9429973	The primary endpoint was safety, and adverse events (AEs) were graded according to NCI CTCAE v4.03.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "endpoint", "was...
PMC10936243	And, sometimes, why we don’t really put the bedding in all situations, because sometimes during the recovery process, they will pee and poo… we don’t want the stool or urine to dirty the body” [D122]. “	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	Furthermore, as the number of mutations increased, the docking position between the mutant HBx and MYC had a trend to be tighter (Figure 3A), suggesting that HBx-TM could impact the expression or function of MYC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	According to the literature, common for MPNs JAK2 gene mutations may contribute to the development of venous thrombosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "literat...
PMC11172027	Statistical significance was considered at p < 0.01, with high significance at p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "considered", "at", ...
PMC11794568	WB analysis of the expression of oxidative phosphorylation-related proteins in cutaneous melanoma cells overexpressing and knocking down CRIP1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WB", "analysis", "of", "the", "express...
PMC10024132	First, luciferase and green fluorescent protein (GFP) genes were transduced into VAL cells using lentiviral vectors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "luciferase", "and",...
PMC9429973	IGHV status was often not determined in this real-world study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IGHV", "status", "was", "often", "not", "determined", "in", "this", "real-world", "study", ...
PMC11357960	During SUMOylation, small ubiquitin-like modifiers (SUMO) are covalently attached to target proteins via an enzymatic cascade that requires the sequential action of SUMO activating enzyme, SUMO conjugating enzyme and SUMO ligases (9, 10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	After INO/Blina failure, 54 pts (83%) received subsequent therapy, with a median of 2 therapies (range, 1-6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11761919	A single colony of Fiber2-expressing E. faecalis was inoculated into 5 mL of M17 medium with 10 ng/mL chloramphenicol (Cm) and cultured at 30°C for 12 h. This culture was then inoculated into four conical flasks, each containing 50 mL of M17 medium (10 ng/mL cm) at a 1:50 ratio.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3915447	The apoptosis of CCRF CEM cells, incubated with 10 mg/L SPIO for 72 hours, was 15.8% (p<0.05).	[ { "tags": [ "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC10976516	One evident way of circumventing liver and lung barriers would be the use of an intra-arterial (IA) application route for OV-loaded carrier cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11792766	In summary, the food simulants specified in Commission Regulation (EU) 10/2011 can be efficiently used for preparing FCM samples for in vitro biological testing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6024716	Compared with the parental cell line, both engineered cell lines demonstrated higher expression of luciferase, a stably transfected cytoplasmic protein, and alkaline phosphatase, a transiently transfected secreted protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9352806	Most of the saponins were cucurbitane triterpenoids, including momordicosides P (RT=7.312) and L (RT=1.081), Kuguacin N (RT=9.065) and momordicine I (RT=8.397).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10810426	As positive controls, NIH3T3 cells persistently infected with MLV were also tested.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "positive", "controls", ",", "NIH3T3", "cells", "persistently", ...
PMC10818573	Step 2: The FITC-labeled probe (0.6 μL), 1.5 μL of nfo, and 5 μL of nfo buffer were added to the reaction product of step 1, and the reaction was performed at 39 °C for 20 min. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	p < 0.0001; *, p < 0.001; , p < 0.01; ns, not significant We tested the growth inhibitory effects of Tala with and without Deci in this cell line panel, using the triple negative breast cancer cell line SUM149PT as a control with a naturally occurring pathogenic BRCA1 2288delT mutation in a different genetic background.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	For instance, a cystic fibrosis transmembrane conductance regulator with a phenylalanine deletion at position 508 is targeted by PMQC and is therefore undetectable on the cell surface .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9927933	For genotyping, genomic DNA was isolated from the tips of mouse tails and genotyped using the primer set Ube2c-F (5′-CTGTGGGCAAGCGGTGAGTG-3′) and Ube2c-R (5′-GGTTCAGCTCTGGCACTCAA-3′) to detect floxed (280 bp) and WT (191 bp) alleles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10656496	With the acceptance of MAP chemotherapy into the first strike for all pediatric and Adolescent and Young Adult (AYA) patients, focus has shifted to identifying agents that can improve upon the first strike or become an effective second strike.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9352806	The mobile phase A consisted of 40% water, 60% acetonitrile, and 10 mmol/L ammonium formate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mobile", "phase", "A", ...
PMC9429973	Gender distribution were balance (male 51.6% vs female 48.4%) with median age of 61.0 years and median BMI of 22.5 kg/m.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC4839679	One of the defining features of ccRCC is the increase in glycolysis and activation of the PI3K signaling pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", "the", "de...
PMC11297139	Nuclei were stained with DAPI.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclei", "were", "stained", "with", "DAPI", "." ] } ]
PMC11323699	In the second one, mice were randomized 7 days after tumor inoculation and first treated with olaparib daily for 5 weeks or an identical volume of olaparib vehicle composed of 10% (2-hydroxypropyl)-β-cyclodextrin and 10% DMSO in D-PBS buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5600151	Taratula et al. crosslinked a PPI/siRNA complex with dithiol-containing molecules and coated with LHRH peptide conjugated PEG chains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taratula", "et", "al.", "crosslinked", ...
PMC10507284	However, we observed no significant difference in response to immunotherapy in STS patients with different TROAP expression levels (Figure 5D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC9926039	PHE 76 shows Pi-Pi interaction with methadone The ligand-binding pocket was stabilized through hydrophobic interactions with Phe-76.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PHE", "76", "shows", "Pi-Pi", "interaction", ...
PMC11261875	EVs: extracellular vesicles; GLUT: glucose transporter; HK1: hexokinase 1; PKM2: pyruvate kinase M2; LDH: lactate dehydrogenase; MCT: monocarboxylate transporter; MTV: metabolic tumor volume; PFS: progression-free survival: RFS: recurrence-free survival; SUVbsa: standardized uptake value corrected for body surface area; SUVbw: standardized uptake value corrected for body weight; SUVlbm: standardized uptake value corrected for lean body mass; TLG: total lesion glycolysis Considering substantial evidence regarding lactate and altered cellular metabolism in various cancers, targeting these aspects is now a major focus for pharmaceutical drug development .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	P < 0.05 compared with controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", "compared", "with", "controls", "." ] } ]
PMC11365983	Isolated tissue was snap-frozen in a dry ice bath and stored and stored at − 85 °C until further processing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Isolated", "tissue", ...
PMC11575040	Superenhancers play a role in tumorigenesis and regulate the expression of specific lncRNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Superenhancers", "play", "a", "role", "in", "tumorigenesis", "and", "regula...
PMC11139449	The plates were placed back in the incubator and kept at 37 °C for 24, 48, and 72 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plate...
PMC11680391	A second challenge in self-reporting questionnaires is the impact of negative mood states in the past two weeks prior to answering the questionnaire .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...
PMC9429973	Mutation Profiles: Compared to pts with KIT D816V only, pts who also had ≥1 SRSF2, ASXL1, or RUNX1 mutations had a lower median hemoglobin (p = 0.02), platelet count (p = 0.02), and greater direct bilirubin (p = 0.005), ALP (p = 0.04), and spleen volume (p = 0.06).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11392912	The scores were given on a scale of 1-4: severity; 1, for no visible edema, swelling and redness; 2, for moderately involved joints; 3, for highly involved joints with edema, redness and swelling; 4, for joints severely affected by edema, swelling and redness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718817	Admittedly, differences generated by interventions such as addition of macrophages, IL-18R deficiency, or nigericin treatment are comparatively small and only partly significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Results: Unsupervised clustering using principal component analysis (PCA) and hierarchical clustering revealed two groups that segregated perfectly between hip-derived versus aspirate-derived BMSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11472569	For example, Jaiswal et al. provided evidence that transporter transcripts and regulatory nucleic acids (miRNAs) can be transferred via EVs isolated from ABCB1-overexpressing multidrug-resistant leukemia and breast cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The sequences were analysed using QIIME2 and the SILVA138 database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sequences", "were", "analysed", "using", "QIIME2", "and", "the", "SILVA138", "database", ...
PMC11739484	For instance, MMP7 has been linked to aggressive tumor behavior and poor prognosis in colorectal and gastric cancers, while MMP11 and MMP14 have been implicated in promoting tumor invasion and metastasis in breast and lung cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588008	Our research result is consistent with the findings of previous studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "research", "result", "is", "consistent", "with", "the", "findings", "of", "pre...
PMC11588085	In addition, we found that XIST was down-regulated under hypoxia (Fig. 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "found", "that", "XIST", ...
PMC10788478	Moreover, LGR6 contributes to CSC properties in ovarian, breast, and cervical cancers. , ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "LGR6", "contributes", "to", ...
PMC11746942	The mechanisms leading to sustained STAT3 activation remain to be elucidated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanisms", "leading", "to", "sustained", "STAT3", "activation", "remain", "to", ...
PMC9429973	There were no deaths due to CML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "no", "deaths", "due", "to", "CML", "." ] } ]
PMC11701801	After 6 days, cell viability was measured in the CellTiter-Glo Luminescent Cell Viability Assay (Promega, G7571).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "6", "days", "...
PMC9429973	Summary/Conclusion: In summary, administration of hypomethylating agents to allogeneic SCT resulted in excellent outcomes in children with higher-risk MDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":...
PMC6643347	It is known that humic substances form as a result of the decay of dead organisms and are among the vast reservoirs of organic carbon.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11655536	Quantitative real-time PCR (qRT-PCR) was implemented using the ChamQ SYBR qPCR Master Mix (Vazyme, Nanjing, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", ...
PMC9927933	MEFs were generated from E13.5 embryos with indicated genotypes as described in our previous studies (59, 60), and maintained in DMEM with 15% FBS, 2 mM L-glutamine, and 0.1 mM MEM nonessential amino acids at 37°C in a 5% CO2 humidified chamber.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11277157	Upon viral infection, the innate system is activated, leading to an antiviral defense mechanism mediated by interferon (IFNs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upon", "vira...
PMC10936243	People are very concerned about cost.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "People", "are", "very", "concerned", "about", "cost", "." ] } ]
PMC10667689	More than a decade ago, T-cell immunoglobulin and mucin domain-3 (TIM-3), previously known as an immunoregulator, was identified on AML cells (28, 29).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734	The characterized ORF sequence of the vkorc1 gene from Chinese hamster was deposited into the GenBank database (accession number, AFG26681.1) and cloned into vector p1.2-Zeo to yield plasmid p1.2-Zeo-VKORC1 (Fig. 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541241	In Arabidopsis, scientists detected the content changes of JA and its precursor in raptor1b mutants (Salem et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC10669966	GOT3 (RRID:CVCL_M819), MLS1765-92 (RRID:CVCL_S817), and MLS402-91 (RRID:CVCL_S813) cell lines were established and kindly provided by Prof. Pierre Åman (University of Gothenburg, Sweden); GIST882 (RRID:CVCL_7044) and LPS141 (RRID:CVCL_M823) cell lines were kindly provided by Dr. Jonathan Fletcher (Harvard Medical School, Boston, MA, USA); and the SA4 (RRID:CVCL_8910) cell line was kindly provided by Dr. Kjetil Boye (Oslo University Hospital, Oslo, Norway).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11052306	Such a release induced the activation of the caspase-independent apoptotic pathway through severe DNA fragmentation without alteration of the cell cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "a", "rele...
PMC11347429	University of North Carolina (Chapel Hill, NC USA): Patients with influenza virus infection confirmed by rapid-antigen assay or viral PCR performed on nasopharyngeal samples were recruited during hospital admission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772585	MB methylene blue.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "MB", "methylene", "blue", "." ] } ]
PMC11122631	This subfraction was purified by semi-preparative reverse-phase HPLC (C18 column) gradient eluted with acetonitrile/water (0–10 min, 50% acetonitrile; 10–15 min, 50–60% acetonitrile; 15–50 min, 60% acetonitrile) to give compounds 4 (0.9 mg) and 13 (1.6 mg).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10329074	Kaplan–Meier curves for overall survival of N1 subgroups for TCGA-KIRC samples. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan", "–", "Meier", "curves", "for", "overall", "survival", "...
PMC11541409	Metabolite analysis of blood samples from GIST patients revealed significant changes in lipid and lipid-like metabolites, including ceramide, sphingosine, and sphingosine-1-phosphate (S1P), compared to untreated samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	Treatment with TSL led to a dose-dependent reduction in Ki67-positive nuclei, indicating suppressed tumor proliferation (Figure 6B, 2, 6.32 μΜ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9473868	Due to migration of FLSs involved in the RA development and progression, we further examined the effect of BAI on SW982 cell migration through a scratch healing experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11767725	For instance, hyperglycemia-driven advanced glycation end products (AGEs) compromise skin barrier proteins, while imbalances in adipokines and cytokines in obesity shift immune responses and modify epidermal lipid composition, reshaping microbial communities .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	M. A. Canales, T. A. Buchholz, T. Ishikawa, L. M. Fogliatto, J. Bortolini, F. J. Capote Huelva, A. Salar, D. Tucker, E. Vorozheikina, D. Klingbiel, S. Pokala, J. Parreira, S. Nick, K. Hübel Hospital Universitario La Paz, Madrid, Spain; Scripps MD Anderson Cancer Center, San Diego, United States of America; Kobe City Medical Center, General Hospital, Hyogo, Japan; Hospital de Clínicas de Porto Alegre, Porto Alegre; Centro de Pesquisas Oncologicas, Florianopolis, Brazil; Hospital Universitario Puerta del Mar, Cádiz; Hospital del Mar, Barcelona, Spain; Royal Cornwall NHS Trust, Truro, Cornwall, United Kingdom; IQVIA, Medical and Scientific Services, Moscow, Russia; F. Hoffmann-La Roche Ltd, Basel, Switzerland; Uniklinik Köln, Köln, Germany Background: Obinutuzumab is routinely administered as a 3–4-hour infusion in patients (pts) with follicular lymphoma (FL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: In 2020 and 2021, also considering constrains caused by COVID-19 pandemics, we attempted mobilization in our 3 Italian centres of 14 patients with a diagnosis of CD33+ de novo-AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10297204	A high concentration of 99.5% ethanol caused prolonged latency and decreased amplitude, indicating demyelinating changes and axonal degeneration, whereas an ethanol concentration of 30% did not cause any neurological damage (Figure 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8469018	MTT solution (4 mg/mL) was added to the cells after 24 h of incubation with tested compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MTT", "solution", "(", "4", ...
PMC9693627	Next solution 2 was discarded and the samples were incubated in solution 3 (100 mM NH4HCO3 and 20 mM iodoacetamide) in the dark for 20 min, washed twice with water, three times with solution 1, dried in acetonitrile and trypsinized with Trypsin Gold (Promega, WI, USA) in 100 mM NH4HCO3 at 37 °C for 6 h. Peptides were desalted using Pierce C18 Tips, 100 ul according to manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Serious AEs (SAEs) deemed related to ibrutinib reported >30 days after last dose of study drug were collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serious", "AEs", ...
PMC11754094	This is a more limited application that does not require a heuristic approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "a", "more", "limited", "application", "that", "does", "...
PMC9429973	The 12 mo FTF rate of 42.4% was comparable to the one reported from the ASCEMBL study, 57.7%, considering that this group includes more patients who had heavily pre-treated with advanced disease. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10978090	Although patients underwent hemodynamic monitoring (invasive arterial pressure, echocardiography) during their ICU stay, the TPE procedures were remarkably well tolerated by both patients, without any complications, and were not associated with increased fluid requirements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684821	TCR sequencing revealed a conserved TCR-α chain CAXYGGSQGNLIF (where X represents 3–5 amino acids) motif in 10 of 11 individuals that used the TRAJ42 gene that included the TRAJ42-encoded tyrosine residue at position 94–99, depending on TRAV gene usage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10523483	Briefly, chromatin was immunoprecipitated with NRF2 or H1.2 antibody, and qPCR was performed to examine purified DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "chromatin", "was"...
PMC11298021	To evaluate the IC50 of rapamycin in Jurkat cells, the cells were seeded (50 000 cells/well) in 96 well plates and treated with the increasing concentrations of rapamycin for 24, 48, and 72 hours (10, 20, 40, 60, and 80 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10631132

Isoform 5b has been found to be predominantly secreted by OCs and could be used to further define mononuclear cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Isoform", "5b", "has", ...

PMC11721064

From this comprehensive collection, we selected pathways relevant to our specific research question for input into GSEA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "this", "comprehensive", "collection"...

PMC11519583

Proliferation of MPs in TA muscles injected with either Ctx or glycerol was analyzed (g).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proliferation", "of", "MPs", "in", "TA", "m...

PMC11388384

The incubation chamber maintained a humidified 37 °C atmosphere with 5% CO2 and the objective was similarly heated to 37 °C for live-cell experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Warsaw, Poland; IQVIA, Falls Church, United States of America Background: Patients with lymphoid malignancies are at particularly high risk of developing secondary immunodeficiencies (SID).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11682172

The role of the immune system in tumorigenesis is complex and to some extent contradictory.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role", "of", "the", "immune", "system", "in", ...

PMC11551844

It is used in the US for the treatment of many solid tumors such as breast cancer, non-small-cell lung cancer and pancreatic cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11502327

Unfortunately, more than half of the patients will relapse after treatment and develop platinum drug resistance, which poses no small challenge to the chemical treatment of OC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6835428

They also have a low “fusogenicity” attitude, i.e., they are less effective in interacting with cell membranes to allow cell uptake.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11237030

4ʹ, 6- diamidino-2-phenylindole (DAPI) (Invitrogen) was added to visualize the nuclei.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4ʹ", ",", "6-", "diamidino-2-phenylindole", "(", "DAPI...

PMC11721064

p < 0.05, **p < 0.01, ***p < 0.001 Limbal niche facilitated the transdifferentiation of keratinocyte progenitor cells into corneal epithelial cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Patients received oral ciprofloxacin (500 mg daily on Day 3-13) to prevent bacterial infection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "received", "oral", "ciprofloxaci...

PMC10847511

However, given intratumor heterogeneity, when attempting to establish cancer cell lines from tumors with HRD, slow-growing cells may be eliminated and fast-growing cells with highly enhanced alternative mechanisms may be selected.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11594074

MOE default settings for a brief simulation of 1 ns were employed, with a timestep of 2 fs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MOE", "default", "settings", "for...

PMC11746942

The knockdown of S1PR3 corroborated these findings and significantly impaired IL-6-induced STAT3 activation and K17 expression (Fig. 4F).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "knockdown", "of", ...

PMC3730428

In this study, we demonstrate that SAHA sensitizes MPM cells to SMCs in a manner dependent on its ability to downregulate FLIP.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC11512230

Structurally modified plant viruses hold great potential and offer a number of unique advantages since plant viruses are not capable of infecting human cells and are biocompatible with low-cost production.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8526701

Scale bar: 100 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "100", "μm", "." ] } ]

PMC9429973

However, the functional impact of such mutations in the hematopoietic system and MDS have been scarcely studied.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "functional", "i...

PMC11724582

This result was consistent with the results of previous qPCR and survival analyses (Fig. 5).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "result", "was", "consistent", "with", ...

PMC9429973

The primary endpoint was safety, and adverse events (AEs) were graded according to NCI CTCAE v4.03.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "endpoint", "was...

PMC10936243

And, sometimes, why we don’t really put the bedding in all situations, because sometimes during the recovery process, they will pee and poo… we don’t want the stool or urine to dirty the body” [D122]. “

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9621239

Furthermore, as the number of mutations increased, the docking position between the mutant HBx and MYC had a trend to be tighter (Figure 3A), suggesting that HBx-TM could impact the expression or function of MYC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

According to the literature, common for MPNs JAK2 gene mutations may contribute to the development of venous thrombosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "literat...

PMC11172027

Statistical significance was considered at p < 0.01, with high significance at p < 0.001.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "considered", "at", ...

PMC11794568

WB analysis of the expression of oxidative phosphorylation-related proteins in cutaneous melanoma cells overexpressing and knocking down CRIP1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WB", "analysis", "of", "the", "express...

PMC10024132

First, luciferase and green fluorescent protein (GFP) genes were transduced into VAL cells using lentiviral vectors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "luciferase", "and",...

PMC9429973

IGHV status was often not determined in this real-world study.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IGHV", "status", "was", "often", "not", "determined", "in", "this", "real-world", "study", ...

PMC11357960

During SUMOylation, small ubiquitin-like modifiers (SUMO) are covalently attached to target proteins via an enzymatic cascade that requires the sequential action of SUMO activating enzyme, SUMO conjugating enzyme and SUMO ligases (9, 10).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

After INO/Blina failure, 54 pts (83%) received subsequent therapy, with a median of 2 therapies (range, 1-6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11761919

A single colony of Fiber2-expressing E. faecalis was inoculated into 5 mL of M17 medium with 10 ng/mL chloramphenicol (Cm) and cultured at 30°C for 12 h. This culture was then inoculated into four conical flasks, each containing 50 mL of M17 medium (10 ng/mL cm) at a 1:50 ratio.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3915447

The apoptosis of CCRF CEM cells, incubated with 10 mg/L SPIO for 72 hours, was 15.8% (p<0.05).

[ { "tags": [ "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...

PMC10976516

One evident way of circumventing liver and lung barriers would be the use of an intra-arterial (IA) application route for OV-loaded carrier cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11792766

In summary, the food simulants specified in Commission Regulation (EU) 10/2011 can be efficiently used for preparing FCM samples for in vitro biological testing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6024716

Compared with the parental cell line, both engineered cell lines demonstrated higher expression of luciferase, a stably transfected cytoplasmic protein, and alkaline phosphatase, a transiently transfected secreted protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9352806

Most of the saponins were cucurbitane triterpenoids, including momordicosides P (RT=7.312) and L (RT=1.081), Kuguacin N (RT=9.065) and momordicine I (RT=8.397).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10810426

As positive controls, NIH3T3 cells persistently infected with MLV were also tested.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "positive", "controls", ",", "NIH3T3", "cells", "persistently", ...

PMC10818573

Step 2: The FITC-labeled probe (0.6 μL), 1.5 μL of nfo, and 5 μL of nfo buffer were added to the reaction product of step 1, and the reaction was performed at 39 °C for 20 min. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740508

p < 0.0001; ***, p < 0.001; **, p < 0.01; ns, not significant We tested the growth inhibitory effects of Tala with and without Deci in this cell line panel, using the triple negative breast cancer cell line SUM149PT as a control with a naturally occurring pathogenic BRCA1 2288delT mutation in a different genetic background.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10589262

For instance, a cystic fibrosis transmembrane conductance regulator with a phenylalanine deletion at position 508 is targeted by PMQC and is therefore undetectable on the cell surface .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9927933

For genotyping, genomic DNA was isolated from the tips of mouse tails and genotyped using the primer set Ube2c-F (5′-CTGTGGGCAAGCGGTGAGTG-3′) and Ube2c-R (5′-GGTTCAGCTCTGGCACTCAA-3′) to detect floxed (280 bp) and WT (191 bp) alleles.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10656496

With the acceptance of MAP chemotherapy into the first strike for all pediatric and Adolescent and Young Adult (AYA) patients, focus has shifted to identifying agents that can improve upon the first strike or become an effective second strike.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9352806

The mobile phase A consisted of 40% water, 60% acetonitrile, and 10 mmol/L ammonium formate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mobile", "phase", "A", ...

PMC9429973

Gender distribution were balance (male 51.6% vs female 48.4%) with median age of 61.0 years and median BMI of 22.5 kg/m.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC4839679

One of the defining features of ccRCC is the increase in glycolysis and activation of the PI3K signaling pathway .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "of", "the", "de...

PMC11297139

Nuclei were stained with DAPI.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclei", "were", "stained", "with", "DAPI", "." ] } ]

PMC11323699

In the second one, mice were randomized 7 days after tumor inoculation and first treated with olaparib daily for 5 weeks or an identical volume of olaparib vehicle composed of 10% (2-hydroxypropyl)-β-cyclodextrin and 10% DMSO in D-PBS buffer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5600151

Taratula et al. crosslinked a PPI/siRNA complex with dithiol-containing molecules and coated with LHRH peptide conjugated PEG chains.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taratula", "et", "al.", "crosslinked", ...

PMC10507284

However, we observed no significant difference in response to immunotherapy in STS patients with different TROAP expression levels (Figure 5D).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...

PMC9926039

PHE 76 shows Pi-Pi interaction with methadone The ligand-binding pocket was stabilized through hydrophobic interactions with Phe-76.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PHE", "76", "shows", "Pi-Pi", "interaction", ...

PMC11261875

EVs: extracellular vesicles; GLUT: glucose transporter; HK1: hexokinase 1; PKM2: pyruvate kinase M2; LDH: lactate dehydrogenase; MCT: monocarboxylate transporter; MTV: metabolic tumor volume; PFS: progression-free survival: RFS: recurrence-free survival; SUVbsa: standardized uptake value corrected for body surface area; SUVbw: standardized uptake value corrected for body weight; SUVlbm: standardized uptake value corrected for lean body mass; TLG: total lesion glycolysis Considering substantial evidence regarding lactate and altered cellular metabolism in various cancers, targeting these aspects is now a major focus for pharmaceutical drug development .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7553912

P < 0.05 compared with controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", "compared", "with", "controls", "." ] } ]

PMC11365983

Isolated tissue was snap-frozen in a dry ice bath and stored and stored at − 85 °C until further processing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Isolated", "tissue", ...

PMC11575040

Superenhancers play a role in tumorigenesis and regulate the expression of specific lncRNAs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Superenhancers", "play", "a", "role", "in", "tumorigenesis", "and", "regula...

PMC11139449

The plates were placed back in the incubator and kept at 37 °C for 24, 48, and 72 hours.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plate...

PMC11680391

A second challenge in self-reporting questionnaires is the impact of negative mood states in the past two weeks prior to answering the questionnaire .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ...

PMC9429973

Mutation Profiles: Compared to pts with KIT D816V only, pts who also had ≥1 SRSF2, ASXL1, or RUNX1 mutations had a lower median hemoglobin (p = 0.02), platelet count (p = 0.02), and greater direct bilirubin (p = 0.005), ALP (p = 0.04), and spleen volume (p = 0.06).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11392912

The scores were given on a scale of 1-4: severity; 1, for no visible edema, swelling and redness; 2, for moderately involved joints; 3, for highly involved joints with edema, redness and swelling; 4, for joints severely affected by edema, swelling and redness.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11718817

Admittedly, differences generated by interventions such as addition of macrophages, IL-18R deficiency, or nigericin treatment are comparatively small and only partly significant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9429973

Results: Unsupervised clustering using principal component analysis (PCA) and hierarchical clustering revealed two groups that segregated perfectly between hip-derived versus aspirate-derived BMSCs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11472569

For example, Jaiswal et al. provided evidence that transporter transcripts and regulatory nucleic acids (miRNAs) can be transferred via EVs isolated from ABCB1-overexpressing multidrug-resistant leukemia and breast cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The sequences were analysed using QIIME2 and the SILVA138 database.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sequences", "were", "analysed", "using", "QIIME2", "and", "the", "SILVA138", "database", ...

PMC11739484

For instance, MMP7 has been linked to aggressive tumor behavior and poor prognosis in colorectal and gastric cancers, while MMP11 and MMP14 have been implicated in promoting tumor invasion and metastasis in breast and lung cancers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11588008

Our research result is consistent with the findings of previous studies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "research", "result", "is", "consistent", "with", "the", "findings", "of", "pre...

PMC11588085

In addition, we found that XIST was down-regulated under hypoxia (Fig. 5B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "found", "that", "XIST", ...

PMC10788478

Moreover, LGR6 contributes to CSC properties in ovarian, breast, and cervical cancers. , ,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "LGR6", "contributes", "to", ...

PMC11746942

The mechanisms leading to sustained STAT3 activation remain to be elucidated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanisms", "leading", "to", "sustained", "STAT3", "activation", "remain", "to", ...

PMC9429973

There were no deaths due to CML.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "were", "no", "deaths", "due", "to", "CML", "." ] } ]

PMC11701801

After 6 days, cell viability was measured in the CellTiter-Glo Luminescent Cell Viability Assay (Promega, G7571).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "6", "days", "...

PMC9429973

Summary/Conclusion: In summary, administration of hypomethylating agents to allogeneic SCT resulted in excellent outcomes in children with higher-risk MDS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":...

PMC6643347

It is known that humic substances form as a result of the decay of dead organisms and are among the vast reservoirs of organic carbon.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11655536

Quantitative real-time PCR (qRT-PCR) was implemented using the ChamQ SYBR qPCR Master Mix (Vazyme, Nanjing, China).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", ...

PMC9927933

MEFs were generated from E13.5 embryos with indicated genotypes as described in our previous studies (59, 60), and maintained in DMEM with 15% FBS, 2 mM L-glutamine, and 0.1 mM MEM nonessential amino acids at 37°C in a 5% CO2 humidified chamber.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11277157

Upon viral infection, the innate system is activated, leading to an antiviral defense mechanism mediated by interferon (IFNs).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Upon", "vira...

PMC10936243

People are very concerned about cost.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "People", "are", "very", "concerned", "about", "cost", "." ] } ]

PMC10667689

More than a decade ago, T-cell immunoglobulin and mucin domain-3 (TIM-3), previously known as an immunoregulator, was identified on AML cells (28, 29).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5916734

The characterized ORF sequence of the vkorc1 gene from Chinese hamster was deposited into the GenBank database (accession number, AFG26681.1) and cloned into vector p1.2-Zeo to yield plasmid p1.2-Zeo-VKORC1 (Fig. 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11541241

In Arabidopsis, scientists detected the content changes of JA and its precursor in raptor1b mutants (Salem et al., 2017).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC10669966

GOT3 (RRID:CVCL_M819), MLS1765-92 (RRID:CVCL_S817), and MLS402-91 (RRID:CVCL_S813) cell lines were established and kindly provided by Prof. Pierre Åman (University of Gothenburg, Sweden); GIST882 (RRID:CVCL_7044) and LPS141 (RRID:CVCL_M823) cell lines were kindly provided by Dr. Jonathan Fletcher (Harvard Medical School, Boston, MA, USA); and the SA4 (RRID:CVCL_8910) cell line was kindly provided by Dr. Kjetil Boye (Oslo University Hospital, Oslo, Norway).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11052306

Such a release induced the activation of the caspase-independent apoptotic pathway through severe DNA fragmentation without alteration of the cell cycle.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Such", "a", "rele...

PMC11347429

University of North Carolina (Chapel Hill, NC USA): Patients with influenza virus infection confirmed by rapid-antigen assay or viral PCR performed on nasopharyngeal samples were recruited during hospital admission.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11772585

MB methylene blue.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "MB", "methylene", "blue", "." ] } ]

PMC11122631

This subfraction was purified by semi-preparative reverse-phase HPLC (C18 column) gradient eluted with acetonitrile/water (0–10 min, 50% acetonitrile; 10–15 min, 50–60% acetonitrile; 15–50 min, 60% acetonitrile) to give compounds 4 (0.9 mg) and 13 (1.6 mg).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10329074

Kaplan–Meier curves for overall survival of N1 subgroups for TCGA-KIRC samples. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan", "–", "Meier", "curves", "for", "overall", "survival", "...

PMC11541409

Metabolite analysis of blood samples from GIST patients revealed significant changes in lipid and lipid-like metabolites, including ceramide, sphingosine, and sphingosine-1-phosphate (S1P), compared to untreated samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11790599

Treatment with TSL led to a dose-dependent reduction in Ki67-positive nuclei, indicating suppressed tumor proliferation (Figure 6B, 2, 6.32 μΜ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC9473868

Due to migration of FLSs involved in the RA development and progression, we further examined the effect of BAI on SW982 cell migration through a scratch healing experiment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...

PMC11767725

For instance, hyperglycemia-driven advanced glycation end products (AGEs) compromise skin barrier proteins, while imbalances in adipokines and cytokines in obesity shift immune responses and modify epidermal lipid composition, reshaping microbial communities .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

M. A. Canales, T. A. Buchholz, T. Ishikawa, L. M. Fogliatto, J. Bortolini, F. J. Capote Huelva, A. Salar, D. Tucker, E. Vorozheikina, D. Klingbiel, S. Pokala, J. Parreira, S. Nick, K. Hübel Hospital Universitario La Paz, Madrid, Spain; Scripps MD Anderson Cancer Center, San Diego, United States of America; Kobe City Medical Center, General Hospital, Hyogo, Japan; Hospital de Clínicas de Porto Alegre, Porto Alegre; Centro de Pesquisas Oncologicas, Florianopolis, Brazil; Hospital Universitario Puerta del Mar, Cádiz; Hospital del Mar, Barcelona, Spain; Royal Cornwall NHS Trust, Truro, Cornwall, United Kingdom; IQVIA, Medical and Scientific Services, Moscow, Russia; F. Hoffmann-La Roche Ltd, Basel, Switzerland; Uniklinik Köln, Köln, Germany Background: Obinutuzumab is routinely administered as a 3–4-hour infusion in patients (pts) with follicular lymphoma (FL).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: In 2020 and 2021, also considering constrains caused by COVID-19 pandemics, we attempted mobilization in our 3 Italian centres of 14 patients with a diagnosis of CD33+ de novo-AML.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10297204

A high concentration of 99.5% ethanol caused prolonged latency and decreased amplitude, indicating demyelinating changes and axonal degeneration, whereas an ethanol concentration of 30% did not cause any neurological damage (Figure 6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8469018

MTT solution (4 mg/mL) was added to the cells after 24 h of incubation with tested compound.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MTT", "solution", "(", "4", ...

PMC9693627

Next solution 2 was discarded and the samples were incubated in solution 3 (100 mM NH4HCO3 and 20 mM iodoacetamide) in the dark for 20 min, washed twice with water, three times with solution 1, dried in acetonitrile and trypsinized with Trypsin Gold (Promega, WI, USA) in 100 mM NH4HCO3 at 37 °C for 6 h. Peptides were desalted using Pierce C18 Tips, 100 ul according to manufacturer’s instructions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Serious AEs (SAEs) deemed related to ibrutinib reported >30 days after last dose of study drug were collected.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serious", "AEs", ...

PMC11754094

This is a more limited application that does not require a heuristic approach.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "a", "more", "limited", "application", "that", "does", "...

PMC9429973

The 12 mo FTF rate of 42.4% was comparable to the one reported from the ASCEMBL study, 57.7%, considering that this group includes more patients who had heavily pre-treated with advanced disease. *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10978090

Although patients underwent hemodynamic monitoring (invasive arterial pressure, echocardiography) during their ICU stay, the TPE procedures were remarkably well tolerated by both patients, without any complications, and were not associated with increased fluid requirements.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11684821

TCR sequencing revealed a conserved TCR-α chain CAXYGGSQGNLIF (where X represents 3–5 amino acids) motif in 10 of 11 individuals that used the TRAJ42 gene that included the TRAJ42-encoded tyrosine residue at position 94–99, depending on TRAV gene usage.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10523483

Briefly, chromatin was immunoprecipitated with NRF2 or H1.2 antibody, and qPCR was performed to examine purified DNA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "chromatin", "was"...

PMC11298021

To evaluate the IC50 of rapamycin in Jurkat cells, the cells were seeded (50 000 cells/well) in 96 well plates and treated with the increasing concentrations of rapamycin for 24, 48, and 72 hours (10, 20, 40, 60, and 80 µM).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...