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OTAR3088
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BioData-CellLine_annotated

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PMC10114490
Azathioprine 1000 µM samples had protein content lower than 3-times blank samples content and were removed from further analysis.
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PMC9878562
Comparing the data revealed that in general the expression levels of GPCRs transcripts showed no gross differences between the two cell types ( Figure S4B ).
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PMC11638255
The CCA Integration method implemented in Seurat was used to perform integration-based anchoring to correct for batch effect.
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PMC9429973
The rate of VGPR or better improved from 41% to 50% during maintenance.
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PMC7823217
In droplet-based bioprinting approach, different energy sources including sound, temperature, and electricity are used to produce bioink droplets in a high-throughput manner .
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PMC9429973
There were no adverse events related to study procedures EGD or USG.
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PMC9351137
Those defects are consistent with the localization of the CRS of interest to the mitotic apparatus and also occur after the loss of known spindle and/or midbody regulators [4–7, 10–15, 53].
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PMC7171147
Therefore, we propose that blocking FAO might serve as a promising therapeutic target to treat ovarian cancer, particularly cisplatin-resistant recurrent ovarian cancers which typically express high levels of COL11A1.The Warburg effect describes a phenomenon where cancer cells rely on glycolysis for their energy needs even in the presence of oxygen.
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PMC9895440
Data were considered statistically significant with p values <0.05.
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PMC11013014
M.p.
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PMC4369959
The induction of apoptosis by 6-gingerol was mediated through downregulation of cytosolic inhibitor of apoptosis (cIAP)-1 and inhibiting TRAIL-induced nuclear factor-kappaB (NF-κB) activation.
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PMC11705484
Gene Ontology and heatmap analysis revealed enrichment of genes involved in the regulation of mRNA processing and RNA splicing with decreased mA methylation after TRMT61A knockdown; Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that transcripts with decreased mA methylation were significantly related to the spliceosome and cancer pathways (Figure S2B–D).
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PMC10607604
However, the exact role and mechanism of action of PTPN13 in these tumors remain to be investigated.
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PMC7348793
The amplification with GoTaq G2 DNA polymerase (Promega, Madison, WI, USA) was performed with initial denaturation at 95 °C for 1 min, followed by 35 cycles at 94 °C for 10 s, at 55 °C for 15 s, and at 68 °C for 30 s followed by a final extension for 5 min at 68 °C.
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PMC9429973
Combination of CPX-351 with Treg-Tcon HSCT is safe and exert powerful antileukemic activity.
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PMC11767817
Curcumin derivative 2a demonstrated increased potency under hypoxia compared to normoxia in both cell lines.
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PMC8414691
B Detection of SRCAP by Western blotting on protein extracts from isolated midbodies.
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PMC8633974
Subsequently, RT assay from cell supernatant or ddPCR from extracted RNA was performed to measure stimulation index.
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PMC11768281
Another method is using adoptive cell transfer, which involves isolating immune cells, modifying them, and reinfusing them into the host to strengthen immune response sensitivity .
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PMC9429973
On the other hand, with only daily averages of parameters, a deeper understanding of interaction of the collected parameters is challenging.
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PMC7351993
The sort driver generates a predetermined signal waveform through a DAC and consequently actuates the dual-membrane push-pull cell sorter.
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PMC11597291
A mass loss of only 8% was observed at 150–400 °C due to the high thermal stability of the -COOH complexes.
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PMC11092382
The NF-κB pathway is involved in numerous diseases characterized by inflammation, including cancer and ischemia‒reperfusion injury in various organs (Guijarro and Egido, 2001; Hoesel and Schmid, 2013).
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PMC11186948
Quantification of HDAC2 relative enrichment in HD (grey bar) and #249 (red bar) LCLs; all values are expressed as means ± SEM and data analysis was performed using Student’s t-test as statistical method, with p value < 0.05 To understand whether the different localization of HDAC2 in #249 LCL could be caused by an altered transcription/translation of HDAC2, we investigated both HDAC2 expression and its total protein abundance (Fig. 4).
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PMC9429973
VEN-O ranked the first also for MRD (SUCRA 90.4%, probably best 36.2%) versus the second VEN-O-IBR (SUCRA 84.0%, probably best 35.9); in the direct comparison, the difference between VEN-O and VEN-O-IBR is not statistically significant (Odds Ratio 1.44, CrI 0.00,563.57).
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PMC4270159
MCF7 cells.
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PMC10812665
As the patterns of MPP, Rot and Ber resembled one another, and as Ber is the compound least characterized yet, all following data refer to this toxicant.
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PMC9429973
Based on these barriers and facilitators a clear and comprehensive implementation guide was developed for digital care platforms in general.
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PMC11285179
Our study showed that after undergoing anti-angiogenesis treatment, the tumor exhibited a state of ischemia and hypoxia, leading to an upregulation in the expression of CCL28 in hypoxic lung adenocarcinoma cells by the hypoxia-sensitive transcription factor CEBPB.
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PMC11306331
Source data is provided as a Source Data file.
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PMC9429973
Changes in the transcriptome after JIB-04 treatment were analyzed in AML-OCI3 and MOLM-13 cells.
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PMC11045125
Furthermore, we demonstrate that LMP1 expression in human BL cells with type I latency is sufficient to turn on expression of STAT3 and Src kinase and to induce high levels of Y705-phosphorylated STAT3.
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PMC11486946
In particular, this technique can detect changes in the physical properties of the target receptor, which include the lateral diffusion and the statistical distribution of receptor clusters, both of which are difficult to detect using biochemical methods.
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PMC11585587
The Search Tool STRING database (https://string-db.org/) was used to construct the protein–protein interaction (PPI) network for selecting target genes.
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PMC9429973
Hospitalization was required only for the first cycle (subsequent cycles were allowed to be administered in an outpatient setting).
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PMC9559528
WBC: white blood cell; RBC: red blood cell; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: MCH concentration; RDW: RBC distribution width; MPV: mean platelet volume; HDL: high-density lipid; LDL: low-density lipid; ALT: alanine aminotransferase; AST: aspartate aminotransferase; RPR: rapid plasma reagin; TPHA: T. pallidum hemagglutination assay; HIV rapid test: 3rd-generation VIKIA HIV 1/2 rapid test HIV antigen/antibody assay: 4th-generation ADVIA centaur HIV combo assay The patient was treated with amoxicillin/clavulanic acid 2 g/day, acitretin 50 mg/day, vitamin E 4000 IU/day, chlorpheniramine 4 mg/day, zinc 20 mg/day, topical salicylic acid 5%, eosin 2%, and calcipotriol/betamethasone for suspected psoriasis with overlying skin infection pending additional laboratory and pathology evaluation.
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PMC11730311
Shorter half-lives were observed for hαCGRP8-37 derivatives conjugated with C20DA-γGlu at position 20 and 25.
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PMC10587429
At week 6, the average percentage of hCD45 cells had increased to 80%.
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PMC11637276
Monolayers were manually scratched into a cross shape with the help of a 200 μl pipette tip.
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PMC7433824
TCPG belongs to the chaperonin‐containing T‐complex (TRiC) which regulates the folding of WRAP53/TCAB1 and provides telomere maintenance.
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PMC11670954
These effects are mediated through the activation of the RhoA/ROCK2/MLCK signaling pathway.
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PMC11718817
Notably, macrophage coculture significantly increased the average speed of CTLs, but, only when macrophages had been treated with LPS and nigericin for NLRP3 activation (Figure 2A).
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PMC4369959
This anticancer activity of ginger leaf extract was attributed to the increased expression of ATF3 through ERK1/2 activation in human colorectal cancer cells .
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PMC11337594
A375 cells that still retain the ability to migrate and invade or have a strong ability to migrate and invade can migrate and invade from the upper layer of the cell chamber by secreting matrix protease to the lower membrane of the cell chamber.
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PMC10452486
The figures also enable the visualization of the aggregation of the HCs monitored by fluorescence photo-bleaching recovery (FPR) and time-resolved phosphorescence anisotropy (TPA), in addition to FCET.
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PMC9786247
increase in the transcription of pro-inflammatory cytokine genes, such as those encoding for IL-1β, IL-12 and TNF-α .
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PMC6892818
Interestingly, blockade of the JNK/AP-1 and p38 pathways fully abrogated induction of both Bax and Bak (Fig. 7c).
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PMC11588008
Wash the RNA precipitate once with 1 mL of 75% ethanol.
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PMC9429973
Aims: To retrospectively analyze a cohort of thrombocytopenic patients treated with LZ for FN in a single center, evaluating bleeding risk and impact on PLT recovery time.
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PMC11513011
Panel A. The IHC score of cleaved-Caspase-3 increased in KK-47-bearing mice and T24-baring mice by DIB treatment (p < 0.05), but not in 5637-bearing mice.
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PMC2193049
20S proteasome was eluted with 20 mM Tris–HCl (pH 7.6) and 2 M NaCl.
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PMC10443665
The entire procedure took approximately 5 months yielding a resistant subline able to grow at 0.6 μM MTX.
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PMC9429973
Using the extensive Danish health data registers, we collected data on incident hematological malignancy for 3 years following the CBC.
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PMC11703992
Eventually, the score of regulon activity in each cell was calculated to estimate the intensity of different TFs in CD4+ Memory T cell subtypes.
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PMC7553912
The samples were then passed through a nylon mesh (100-μm pore size; BD Biosciences, San Jose, CA) and centrifuged at 1200 rpm for 5 min.
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PMC11787355
Glioblastoma cells and immune cells were identified based on the absence of EGFP and presence of B2M, respectively (Fig. 6b, Supplementary Fig. 11a, b), as host feeder organoid cells are engineered to be EGFP-expressing and B2M-deficient.
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PMC10728200
Flow cytometry analysis utilized the FITC filter for oxidized C11-BODIPY (emission: 510 nm) and the PE-TexasRed filter for reduced C11-BODIPY (emission: 590 nm).
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PMC11721295
Pulmonary lesions disappeared in the OFF groups, likely because of apoptotic cell death described by Fisher et al. (8) and assessed here by cleaved caspase 3 (CC3) staining in ECAD epithelial cells (Figure 1K, higher magnification in Supplemental Figure 1E; quantified in Figure 1L).
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PMC11092382
Sophocarpine has been demonstrated to modulate various proinflammatory and anti-inflammatory cytokines through multiple pathways, exerting significant biological effects.
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PMC11772449
Collectively, these results indicate that PFD could inhibit the autophagy process in HCC after Sora treatment.
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PMC11787355
k was analyzed with two-tailed paired t-test.
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PMC11545868
It shares functional similarities with prunetin.
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PMC9024365
Strychnine was diluted in DMSO while glycine and bicuculine were diluted in water, so an equivalent amount of dimethyl sulfoxide (DMSO) or water, respectively, was added as the vehicle control.
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PMC11509309
The specific features of prions make prion diseases particularly challenging to target using traditional therapeutic approaches.
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PMC11577421
For this purpose, biotinylated heparin was immobilized onto streptavidin-coated sensor surfaces at a density of 150 RU.
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PMC11721064
These results indicate that although both P0 and P1 SKCs contain a higher proportion of progenitor cells, P0 SKCs exhibit significant fibroblast contamination.
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PMC10114490
A total of 10 images from cultured cells immunostained with anti-Ki67 antibody were analyzed using ImageJ software.
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PMC11676674
The data indicate that CHO-K1 cells exposed to C. monspeliensis extract for 24 h at concentrations below 75 µg/mL did not demonstrate significant cytotoxicity.
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PMC3164356
CHO cells can be genetically manipulated and grown either as adherent cells or in suspension.
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PMC10213199
In summary, the JYL drug treatment may greatly increase the expression of 26 S proteasome components and their downstream genes (see Fig. 6).Fig.
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PMC9351137
As shown in Fig. 8, SRCAP depletion clearly affects the localization of both CFDP1 and BAF53a, but not that of p400, Tip60, GAS41, and YL1.Fig.
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PMC9429973
Summary/Conclusion: Given the rarity of IE in neutropenic patients, routine investigation with echocardiography seems not indicated.
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PMC9429973
However, due to the small number of cases, it needs to be further confirmed by multi-center, randomized controlled studies.
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PMC11789597
Targeting CAV1 regulated glutamine metabolism and enhanced the therapeutic efficiency of bortezomib.
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PMC11519788
This analysis revealed seven cytokines/chemokines were downregulated in T24 cells with SPOP overexpression and six were upregulated in SPOP-depleted 5637 cells, respectively (Figure 5F-H).
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PMC11525028
These results indicated that paliperidone and AG-401 from the virtual screen could suppress osteosarcoma progression via the NAT10/ac4C/ATF4/ASNS/Asn axis.
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PMC9096373
Survival curves were fitted based on the Kaplan-Meier method, and P<0.05 was considered statistically significant.
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PMC11792090
In vivo verification of tumor-killing ability and safety of SAP UCAR-T cells (A) Mice bearing U251 tumors received injections of PBS, 2×10 mock T cells, mock CAR-T cells, UCAR-T cells, or SAP UCAR-T cells, with continuous monitoring of tumor volumes and body weights. (
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PMC8662250
Interestingly, in the presence of PPAR‐γ antagonist GW9662 (9 nM), the protective effect of CBD (10 M) both on cell viability and on pyroptotic bodies formation induced by SARS‐CoV‐2 SP was almost completely inhibited (Figure 1a–c).
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PMC11656657
The flow-cytometry analysis conducted on the tumor tissues revealed positive expression of GD2 in 54.7% (35 out of 64) of the analyzed samples (Fig. 1D).
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PMC8978939
This work was supported by Instituto Nacional del Cáncer, Ministerio de Salud, Argentina (Grant 2014-2016, awarded to PP) and Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, Argentina (PIP#0100214, 2013-2015, awarded to PP).
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PMC11529598
Six-to-eight-week-old male BALB/c nude mice from Chinese Academy of Sciences Slake were used for all experiments in this work.
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PMC11106977
Recent studies have demonstrated that O-GlcNAcylation is a prerequisite for osteoclast differentiation from these precursor cells, indicating that O-GlcNAcylation also plays a role in the formation of osteoclasts.
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PMC11476222
Two solvent systems, mobile phase A (MPA) and mobile phase B (MPB), were combined to form a binary gradient.
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PMC11578343
Error bars in A correspond to standard error.
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PMC11171319
We believe that the latency phase is an important player in the transforming process of epithelial cells infected with HR-HCMV since in chronically infected transformed cells, we detect very low levels of HCMV with reactivation by MIEP activators such as TPA or HDAC inhibitors.
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PMC5673060
Lists of phosphoproteins from enrichment clusters were generated and further investigated using the online application STRING 10.5 to construct protein networks and analyse their associations.
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PMC11731614
Insert: GO Term ‘Axon Development’ revealed several unverified notable proteins as EV cargo.
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PMC10873328
After transfected with specific siTGFBI or siNC, A2780/CDDP cells were seeded on a 96-well plate and cultivated for 24 h for the IC50 assay of cisplatin treatment (0, 2.5, 5, 10, 20, 40, 80, 160, 320, 640 µM/L).
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PMC11320834
The 31.25 nM TLL and 200 μM OLL combination resulted in a CI of 0.13 (p ≤ 0.01); an OLL DRI of 42.5, and an estimated TLL DRI of 9.6.
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PMC11560255
The findings suggest that PMBE triggers apoptosis in cervical cancer cells.
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PMC11730305
Furthermore, the increased cell apoptosis confirms the antiproliferative potential of Co3O4@Glu-Ellagic acid NPs.
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PMC11186948
AlphaLISA analyses allowed comparing acetylation levels relative to lysine 27 of histone H3 (H3K27Ac) normalized on unmodified lysine 4 of histone 3 (H3K4) in LCLs, in particular between #249, HD and LCLs derived from RSTS patients with mutation in the major gene CREBBP (CREBBP) (Fig. 5A).
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PMC9429973
Methods: The study included 117 patients: 51 men and 66 women, aged 19 to 67 years, with Hodgkin’s lymphoma (HL) - 88, acute lymphoblastic leukemia (ALL) - 16 and aplastic anemia (AA) - 13 patients.
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PMC11429241
The reaction was started for 5 min at 95 °C and continued with 40 cycles of 10 s of denaturing at 95 °C and 30 s of annealing/extension at 60 °C.
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PMC5574817
This article describes the construction of human embryonic kidney 293 (HEK293) cells overexpressing HERG potassium channel and verification of the presence of hERG mRNA and protein expression in this recombinant cell line.
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PMC10421378
For example, Lactobacillus rhamnosus LGG and Lactobacillus mucosae LM1 express lectins that interact with carbohydrates on the intestinal epithelial cells, promoting adhesion .
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PMC9000591
This combination was then incubated in the dark at room temperature for 30 min.
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PMC9684669
Moreover, our research demonstrated that terfenadine directly bound to CAMKIID to prevent its autophosphorylation and inhibit the activation of the cAMP-responsive element-binding protein 1 (CREB1)-mediated pathway.
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PMC11599565
Likewise, the PNMA1 neuronal marker was also overexpressed in cisplatin treated cells (Fig. 7, Panel A, pictures L vs. P).
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