Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9621239
DM, double mutation, refers to S101P/L123S.
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PMC11741906
However, tumor cells can acquire a complex network of mechanisms to evade cisplatin-induced cell death and survive .
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PMC11650848
Fig. 3Methylation quantitative trait loci in the differentially methylated region of ZFP57.
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PMC11518994
In contrast to previously described PAX5 germline families [3–9], our patients exhibit a germline frameshift variant that is predicted to cause a premature arrest of the protein synthesis (predicted MW 30KDa).
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PMC11754784
d Simulated generation rate of c-sgc8c and CD47-Nb in DNP1 and DNP3-based computation.
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PMC9118379
Distribution of 320 variant PSMs supported by 0–3 OMS tools.
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PMC4485786
Strikingly, sarcomas of FcIL-7-treated mice only had a minor infiltrate containing exclusively macrophages (CD68) and NK cells (CD56) (Fig. S3).
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PMC11786704
Quantitative data of apoptotic cells by flow cytometry. (
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PMC9429973
Patients are randomized (1:1) to receive M-Len (M intravenously [IV] on Days [D] 1, 8 and 15 of Cycle [C] 1 [21-day cycle] and D1 of C2–12 [28-day cycles], plus Len orally [PO] on D1–21 of C2–12) or R-Len (R IV on D1, 8, 15 and 22 of C1 then on D1 of C3, 5, 7, 9, and 11, plus Len PO on D1–21 of C1–12 [all 28-day cycles]), and stratified by disease progression within 24 months of initial treatment (yes/no), number of prior lines of therapy (1 versus β‰₯2), and refractoriness to anti-CD20 therapy (refractory/non-refractory).
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PMC11534377
The treatment group exhibits a diminished signal, suggesting a reduction in tumor progression due to the 5-Aza therapy, with no visible macroscopic tumors on the lungs at the end of the experiment.
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PMC9429973
Methods: Eligible adults had R/R CD22+ B-ALL with β‰₯5% blasts in blood/marrow or β‰₯1 site of extramedullary disease [EMD] β‰₯1.5 cm in diameter.
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PMC9429973
Median (min–max) age at HCT was 56 (19–74) years, going from 44 years in 2000–2005 to 59 years in 2016–2020.
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PMC11513571
Poly I:C) (InvivoGen, USA) were used to stimulate the cells.
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PMC9684669
Despite the fact that numerous ABCB1 inhibitors have been developed, their clinical translation has been limited due to their low binding affinities, excessive toxicity, or non-specificity (13, 14), indicating the need for new ABCB1 transporter inhibitors or strategies to overcome the MDR caused by ABCB1 overexpression.
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PMC11257203
Data represent the mean Β± SD of three separate experiments. *
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PMC9429973
Across all arms, abnormal counts of T cell subsets, classical monocytes and conventional DCs characteristic of CLL were normalized to healthy donor levels (β€’49%, +101% and +91% respectively) within the first 6 months of tx and were maintained thereafter regardless of randomized tx.
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PMC11224020
CCR7 is in gray, and nuclei are in red; scale bar, 10 Β΅m.
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PMC11658074
These findings further support the conclusion that the presence of AT substantially mitigates UVB-induced photoaging, leading to the rejuvenation of ageing skin.
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PMC11696576
Targeting their production by inhibiting Group IVA cytosolic phospholipase A2 (cPLA2Ξ±) offers a promising approach for cancer therapy.
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PMC11474209
The sensor worked with spiked samples, indicating visual and microcystin analog detection.
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PMC11401358
Local oxidative stress in diseases or injury severely hinders cell homeostasis and organ regeneration.
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PMC11711663
We chose a threshold that maximizes predictive accuracy using cross-validated log-likelihood (CVL).
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PMC11794588
Gautam et al.highlighted the anticancer properties of Ξ²-amyrin, demonstrating its ability to inhibit cell growth and induce cell cycle arrest in HeLa cells.
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PMC11087301
Compatible with the elevation of EMT as a vital early step in cancer metastasis, low expression of the miR-200 family has been comprehensively evidenced to occur within EMT and in aggressive breast malignancies.
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PMC11676670
In contrast to the common models, OVAR79 expresses TP53 without the common hotspot mutations and harbors the rare combination of mutations in both PIK3CA and PTEN genes, together with high-grade chromosomal instability with multiple gains and losses.
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PMC9429973
The combination of PT-Cy and ATG also shows reduced absolute numbers of CMV-specific CD8+ T cells compared to ATG protocols (ATG 40 mg/kg/day intravenously for 4 days).
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PMC11343332
The number of cells decreased after pycnogenol treatment, and the cells exhibited cell shrinkage and cytoplasmic membrane blebbing.
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PMC9429973
Cellular response was not corelated with the time elapsing from last immunochemotherapy.
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PMC10170482
Therefore, we conclude that downregulation of Bcl-2 expression upon culturing HepG2 cells in soft 3D CS conditions results in the sensitization of cells toward HFLP laser-induced toxicity.
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PMC11352746
Real-time cellular analysis allows for a greater understanding of biological systems without impacting the system itself.
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PMC6379402
To measure the fit between a real network (e.g., iCell) and a given random model (e.g., ER), we generated for each real network 30 random networks from the given model that have node sizes and edge densities of the real network.
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PMC9031474
The two groups performed different cell viability assays and control culture treatments to measure the cytostatic effects of 49 which might lead to different results.
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PMC9622879
DeviceHome 1Home 2Home 3Home 4Home 5Home 6Home 7Home 8Home 9Home 10PV ()10101055XXXXXESS (kWh)101010XX55XXX PV system and ESS at each home.
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PMC11394730
Furthermore, tribbles homolog 3 (TRIB3)’s function was ascertained through small interfering RNA (siRNA) knockdown.
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PMC9429973
Aims: To assess the association of MF disease duration before treatment with disease outcomes using pooled COMFORT data Methods: COMFORT I (NCT00952289) and COMFORT II (NCT00934544) were phase 3 trials of RUX vs PBO or BAT, respectively, in pts with intermediate-2 or high-risk MF who provided written informed consent.
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PMC9429973
Y. Sha, Y. Miao, S. Qin, R. Jiang, W. Wu, Y. Xia, L. Wang, L. Fan, W. Xu, H. Jin, H. Zhu, J. Li Department of Hematology, The First Affiliated Hospital of Nanjing Medical University; Department of Hematology, Pukou CLL Center, Pukou division of Jiangsu Province Hospital, Nanjing, China Background: Richter Syndrome (RS) is defined as development of aggressive lymphoma arising from chronic lymphocytic leukemia/Small lymphocytic leukemia (CLL/SLL).
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PMC11063646
Ensuring the appropriate consistency of an emulgel formulation is crucial for application and patient acceptance (Malavi et al., 2022).
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PMC11525028
Tumor size was measured and calculated using the formula: width Γ— length Γ— Ο€/6, as described.
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PMC11594806
This group conducted a differential proteomic analysis, revealing that P2XR4 is the only purinergic receptor upregulated in endothelial cells upon stimulation by tumor-derived MVs.
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PMC11726183
In compounds 19–25, another peak is observed in the range of 11.32–14.64 ppm which can be attributed to iminol group.
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PMC9429973
Overall longer PFS and better response to lenalidomide-based first-line therapy can be expected.
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PMC9786247
Another set of determinants to be considered that are instrumental for limiting C. burnetii replication and subsequent shedding in milk are the local inflammatory responses after some rounds of replication in tissue-specific cells.
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PMC11532793
Transcript counts were scaled, non-expressed transcripts were filtered by filterByExpr, genes other than protein-coding and lncRNA were removed, and library sizes were normalized by normLibSizes.
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PMC9429973
Multivariate analysis was performed to find independent factors for MMR.
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PMC9429973
We also evaluated T and B maturation subsets.
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PMC9429973
Covalent BTKi share pharmacologic liabilities (e.g. low oral bioavailability, short half-life) that collectively may lead to suboptimal BTK target coverage, for example in rapidly proliferating tumors with high BTK protein turnover such as accelerating CLL/SLL, ultimately manifesting as acquired resistance in some patients.
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PMC11684821
We recently discovered an MR1-restricted T cell clone with an Ξ±Ξ² TCR that allowed it to target a wide range of cancer cell lines and also control human leukemia cells in an NSG mouse model (18).
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PMC11377827
VEGF: control vs. Set1B sgRNA ****P < 0.0001.
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PMC11596967
These leaderless genes vary significantly across genomes, with a prevalence ranging from 3.3% to 53.6% .
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PMC10135767
In this study, we evaluated the calcium response of RPMI 8226 cells that adhered to the 10 g/mL MAdCAM-1-coated bottoms under wall shear stresses of 0.15, 0.30, and 0.60 dyn/cm.
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PMC11361748
Neutrophil transwell migration assays were performed in a transwell system consisting of a 24-well tissue culture plate and 3.0-ΞΌm pore size PET membrane inserts (Sterlitech Corporation #9323012).
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PMC11521786
Differences among treatment means in a representative experiment were analyzed by one-way ANOVA, with Tukey’s test applied for multiple comparisons. (
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PMC11627133
After washing the cells, dSTORM images were acquired using an anti‐synaptophysin primary antibody and CF680‐labeled secondary antibody (Figure 6B, Supplementary Movie).
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PMC10079526
B Namalwa cells were cultured in suspension and treated for 4 or 20 h with 1 Β΅M 5-Aza-2’ and/or 1 Β΅M TAK981 or DMSO 0.1% as control with or without MG132 10 Β΅M for 4 h and 2.5 Β΅M for 20 h. Total lysates were analyzed by immunoblotting using antibodies directed against DNMT1 and SUMO2/3.
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PMC11122631
The coral material was frozen to remove water and then extracted by ethanol three times.
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PMC9429973
We detected neutralizing antibodies (nAbs) against SARS-CoV-2 in patients’ sera (ELISA, cPassβ„’ SARS-CoV-2 nAbs Detection Kit; GenScript, Piscataway, NJ, USA), 21 days after each vaccination dose.
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PMC11188874
Treatment with the HDAC6 inhibitors increased hydrolysis of Suc-LLVY-MCA (cleaved by the Ξ²5c and Ξ²5i active sites) as well as hydrolysis of Anc-ANW-MCA that is preferentially cleaved by the Ξ²5i active site.
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PMC11092382
and S. acutum [Thunb.]
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PMC11488203
Thus, a β€œnatural” production of taxol-loaded MSC-derived EVs/exosomes as a therapeutic carrier may display some advantages as compared to synthetic or other taxol-tagged nanoparticles.
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PMC10178190
They home into the tumor site, following secretion of soluble factors, such as IL-6, IL-1Ξ², and/or transforming growth factor-Ξ²1 (TGF-Ξ²1) by tumor cells, as well as the stromal cell-derived factor1Ξ± (SDF-1Ξ±) by stromal cells that promote paracrine signaling in tumor cells.
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PMC9429973
The median follow-up time was 997d(374-1239).
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PMC11351758
Calcium (Ca) plays a critical role in mediating many important biological functions and has been implicated as an intracellular regulatory factor in many physiological and pathological processes in the cell.
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PMC10988808
F Apoptosis assays and the relative quantitative results.
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PMC11411004
Our research indicates that I-4 has the ability to directly inhibit the expression of LSD1 protein.
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PMC9429973
E. Sofou, A. Agathangelidis, A.-M. Antoniadou, E. Georgiou, M. Papaioannou, N. Pechlivanis, F. Psomopoulos, K. Stamatopoulos, A. Chatzidimitriou Institute of Applied Biosciences, Centre for Research and Technology Hellas; Laboratory of Biological Chemistry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki; Department of Biology, School of Science, National and Kapodistrian University of Athens, Athens; 1st Department of Internal Medicine, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Background: In vivo Class Switch recombination (CSR) has previously been reported for a fraction of patients with chronic lymphocytic leukemia (CLL) expressing unmutated IGHV genes (U-CLL) and high mRNA levels of activation-induced cytidine deaminase compared to patients expressing mutated IGHV genes (M-CLL).
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PMC9429973
Aims: Comparison HDCT (CLV, LEAM, BeEAC) as a conditioning regimen before ASCT for the treatment of R/R HL.
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PMC10291556
The oxidation of this complex to Pt(IV) analogue 2 resulted in a significant decrease in activity.
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PMC9429973
All mutations were shown to be located in close proximity of the miRNA binding site, all were destabilizing for protein structure alone with consequent alterations in bonds and protein-miRNA binding.
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PMC11261875
GLUT serves as the initial rate-limiting step in cellular glucose metabolism.
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PMC11267830
To understand the impact of aberrant alternative splicing on protein levels, we performed transcriptomic and proteomic analyses of the J.gamma1 cell line after indisulam treatment at a later time point (5 Β΅M, 16 h).
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PMC11730311
The A36S possibly strengthen the interaction further by forming hydrogen bonds to CLR G33 and F37.
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PMC11377827
Alongside defining DUBs involved in HIF activation or suppression, we identify USP43 as a DUB required for efficient activation of a HIF response.
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PMC11632064
The specific induction of apoptosis in melanoma cells versus melanocytes (Schmit et al, 2009) has reinforced interest in targeting PLK1 with small molecules (BI 2536 [Jalili et al, 2011; de Oliveira et al, 2012], BI 6727 [Cholewa et al, 2017]) and launching clinical trials (BI 6727 [Lin et al, 2014] and other inhibitors, reviewed in Chiappa et al ).
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PMC9577200
Flow cytometric analysis of apoptosis induction in HeLa cells treated with different concentrations of chitosan.
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PMC11066331
We were therefore curious if the protocol we established previously for stem cell quality control can be used for tracing minute changes in cell phenotype .
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PMC11759751
Kaplan–Meier survival analysis found that the Chidamide + CD19 CAR T group had the highest survival rate compared with the other three groups (Fig. 6D).Fig.
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PMC7351993
For this identification, the ratio of the intensities obtained in the GFP and TRITC channels of Nile Red-labeled PS particles was measured and used as a threshold.
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PMC10656496
First strikes like surgery and MAP chemotherapy greatly reduce and eliminate the dominant population, but by this definition second strikes are needed to eliminate the minor, resistant population.
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PMC8873393
The mixture was centrifuged (3500 Γ— g, 10 min, 4 Β°C) and the supernatant was collected as the cytoplasmic fraction.
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PMC9812014
Other alkaloids have also been reported to have good binding affinities with important enzymes of SARS-CoV-2 in bioinformatics studies .
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PMC11566417
Fibroblast migration assays were carried out, as previously described .
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PMC11711871
The data were considered significant at *.P < 0.05 and **P < 0.01Table 1Resting tension and precontraction of isolated aortic vascular ringsNSDHSDGRGRGRGRNumber of rats5576RT2.28 Β± 0.032.33 Β± 0.042.35 Β± 0.032.30 Β± 0.04RDT before ACh3.90 Β± 0.194.51 Β± 0.474.14 Β± 0.343.64 Β± 0.40RDT before DEA/NO5.61 Β± 0.296.24 Β± 0.285.88 Β± 0.155.72 Β± 0.32RT resting tension, RDT residual tension achieved after precontraction with 10 M phenylephrine before adding cumulative concentrations of the vasodilator acetylcholine (ACh) (in the absence of the eNOS inhibitor NG-nitro-L-arginine, NLA) or DEA/NO (in the presence of NLA).
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PMC9429973
According to nosology, patients were divided into following groups: lymphomas - 72%, MM - 12%, AA and CML 8% each.
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PMC8481254
Importantly, we found that CA can reduce YAP expression and O-GlcNAcylation by inhibiting the activity of CDK19.
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PMC8557138
These organoid models often employ patient-derived induced pluripotent stem cells (iPSCs), which enables the formulation of personalized drug profiles to develop precision medicine protocols.
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PMC10440586
The Kaplan-Meier curves consistently showed that the high-expression group presents less favorable survival (Fig. 4D).
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PMC10568263
Despite the excellent electrochemical sensing performance of the electrochemical immunosensor designed for HSP70, it is crucial to emphasize that this protein is not exclusively targeting lung cancer and could be associated with other diseases.
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PMC11087055
Immunostained chick embryos were imaged by Leica TCS SPE confocal microscope and Crest LFOV Spinning Disk with Nikon Ti2-E. Fixed ISH samples were imaged by Leica MZ16F microscope with Leica DFC300 Fx camera and Leica FireCam V.3.4.1 software.
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PMC11676674
Two molecules were analyzed using a standard, as we just used 2 standards from our personal library for the identification of catechin and myricitrin (Myricetin-3-O-rhamnoside).
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PMC11587606
Silencing the RHBDF1 gene in experimental tumor models leads to apoptosis and autophagy in breast cancer and neck squamous cell cancer cells and inhibition of tumor growth .
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PMC11759543
n = 4–6; βˆ—βˆ—p < 0.01) (D) Body weight curve of each treatment group from day 14 to day 27 using day 14 as 100 %. (
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PMC10237474
The media were exchanged for selection media with various antibiotic selection concentrations on day 1.
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PMC8750422
A549 Red-FLuc lung adenocarcinoma cells were purchased from PerkinElmer (Waltham, MA, USA) and A427 lung adenocarcinoma cells were purchased from the Korean Cell Line Bank (KCLB, Seoul, Korea).
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PMC11484188
After 48 h of incubation at 37˚C, cell viability was assessed using a Cell Counting Kit-8 (CCK-8) assay (cat.
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PMC10988555
Still, the development of half-sandwich organometallic cobalt complexes remains scarcely explored.
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PMC10743717
The results are just opposite to the prediction by some members of the JBC editorial board who insisted on there being nothing wrong in those JBC articles .
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PMC9429973
Treatment was based on a pediatric inspired protocol (HOVON 70, Rijneveld et al., 2011) with reduced doses of anthracyclines, MTX, etoposide and PEG-ASP for pts β‰₯40y old.
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PMC11285179
The activation or inhibition of these signaling pathways can modulate the activity of intracellular metabolic enzymes, affecting processes such as glucose metabolism, lipid synthesis, and amino acid utilization.
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PMC11365427
We observed that when MM cells were cultured in a phenylalanine-free environment, the cell density was significantly lower (Fig. 3C).
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PMC9429973
Results: CA/CA genotype of SOCS-1 was found to be statistically significantly higher in healthy controls (p=0,001), while Del/Del genotype was significantly higher in patients with MM (p=0,034).
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