OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	BM Tfr2 deficient mice maintained RBC count and Hb levels higher than controls until 30 weeks after FLT without any transfusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BM", "Tfr2", "deficient", "mice", "maintained", "RBC", "count", "and", "Hb", "levels", "higher", "than", "controls", "until", "30", "weeks", "after", "FLT", "without", "any", "transfusion", "." ] } ]
PMC9429973	Approximately 50% of patients discontinued treatment; 37% had ≥4 lines of treatment and 16% had ≥5 lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "50", "%", "of", "patients", "discontinued", "treatment", ";", "37", "%", "had", "≥4", "lines", "of", "treatment", "and", "16", "%", "had", "≥5", "lines", "." ] } ]
PMC6267596	Profile plot showed that 404 up-regulated and 605 down-regulated genes follow the same pattern across treatment vs control in all biological replicates. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Profile", "plot", "showed", "that", "404", "up-regulated", "and", "605", "down-regulated", "genes", "follow", "the", "same", "pattern", "across", "treatment", "vs", "control", "in", "all", "biological", "replicates", ".", "(" ] } ]
PMC6442998	Multiple examples of drug repurposing exist in various domains, including cancer therapy and even in GIST .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiple", "examples", "of", "drug", "repurposing", "exist", "in", "various", "domains", ",", "including", "cancer", "therapy", "and", "even", "in", "GIST", "." ] } ]
PMC9429973	Aims: We aimed to identify the clinical characteristics and clinical outcome caused by CRE-BSI.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "We", "aimed", "to", "identify", "the", "clinical", "characteristics", "and", "clinical", "outcome", "caused", "by", "CRE-BSI", "." ] } ]
PMC9503541	According to Worley and Powers (2012), PCA scores only show separation between groups when “within-group variation” is much less than “between-group variation” in the data, while PLS scores may show separation at random .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "Worley", "and", "Powers", "(", "2012", ")", ",", "PCA", "scores", "only", "show", "separation", "between", "groups", "when", "“", "within-group", "variation", "”", "is", "much", "less", "than", "“", "between-group", "variation", "”", "in", "the", "data", ",", "while", "PLS", "scores", "may", "show", "separation", "at", "random", "." ] } ]
PMC11026382	For the purposes of modeling, we approximated DHFR and TYMS as a two-enzyme cycle in which DHFR produces THF and consumes DHF, and TYMS produces DHF and consumes THF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "purposes", "of", "modeling", ",", "we", "approximated", "DHFR", "and", "TYMS", "as", "a", "two-enzyme", "cycle", "in", "which", "DHFR", "produces", "THF", "and", "consumes", "DHF", ",", "and", "TYMS", "produces", "DHF", "and", "consumes", "THF", "." ] } ]
PMC10154881	C, D) Evaluation of the antitumor effect of rMV‐SLAMblind in an immunocompetent mouse model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "D", ")", "Evaluation", "of", "the", "antitumor", "effect", "of", "rMV‐SLAMblind", "in", "an", "immunocompetent", "mouse", "model", "." ] } ]
PMC11591794	With the HeLa cell line, the possible synergistic or antagonistic effects of DOX and GA on molecules that play an important role in the apoptotic signaling pathways, P53/Bax expression, and cell proliferation/migration were investigated.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "HeLa", "cell", "line", ",", "the", "possible", "synergistic", "or", "antagonistic", "effects", "of", "DOX", "and", "GA", "on", "molecules", "that", "play", "an", "important", "role", "in", "the", "apoptotic", "signaling", "pathways", ",", "P53/Bax", "expression", ",", "and", "cell", "proliferation/migration", "were", "investigated", "." ] } ]
PMC11699042	Library preparation for bulk 3’-sequencing of poly(A)-RNA was performed as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Library", "preparation", "for", "bulk", "3’-sequencing", "of", "poly(A)-RNA", "was", "performed", "as", "previously", "described", "." ] } ]
PMC9429973	Algorithms hyperparameters of ML were optimized in order to improve performance using GridSearchCV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Algorithms", "hyperparameters", "of", "ML", "were", "optimized", "in", "order", "to", "improve", "performance", "using", "GridSearchCV", "." ] } ]
PMC9429973	A recurrent thromboembolic event was found in 11% (434/3931), of these 9.7% (42/434) had elevated Hb or HCT and 18.7% (81/434) elevated Plt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "recurrent", "thromboembolic", "event", "was", "found", "in", "11", "%", "(", "434/3931", ")", ",", "of", "these", "9.7", "%", "(", "42/434", ")", "had", "elevated", "Hb", "or", "HCT", "and", "18.7", "%", "(", "81/434", ")", "elevated", "Plt", "." ] } ]
PMC9429973	There was no significant association between efficacy of chemotherapy and other studied genotypes, namely GSTP1 C341T, MDR1 C1236T, MDR1 G2677T, MDR1 C3435T genotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "significant", "association", "between", "efficacy", "of", "chemotherapy", "and", "other", "studied", "genotypes", ",", "namely", "GSTP1", "C341", "T", ",", "MDR1", "C1236", "T", ",", "MDR1", "G2677", "T", ",", "MDR1", "C3435", "T", "genotypes", "." ] } ]
PMC11612315	Two-way ANOVA followed by the Bonferroni multiple comparison test (*p < 0.05, vehicle + CAP group compared with the exendin 20–29 [20 μg] group; p < 0.05, p < 0.01, vehicle + CAP group compared with the BCTC [0.5 μg] + CAP) group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "ANOVA", "followed", "by", "the", "Bonferroni", "multiple", "comparison", "test", "(", "*", "p", "<", "0.05", ",", "vehicle", "+", "CAP", "group", "compared", "with", "the", "exendin", "20–29", "[", "20", "μg", "]", "group", ";", "p", "<", "0.05", ",", "p", "<", "0.01", ",", "vehicle", "+", "CAP", "group", "compared", "with", "the", "BCTC", "[", "0.5", "μg", "]", "+", "CAP", ")", "group", "." ] } ]
PMC9429973	More specifically, in myelofibrosis (MF) patients (pts) it has already been reported that the number of circulating hematopoietic precursors is consistently high, with a relative circulating CD34+ cells count of 15 ×10/L as the most frequently used criterion to discriminate between MF and other MPNs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "specifically", ",", "in", "myelofibrosis", "(", "MF", ")", "patients", "(", "pts", ")", "it", "has", "already", "been", "reported", "that", "the", "number", "of", "circulating", "hematopoietic", "precursors", "is", "consistently", "high", ",", "with", "a", "relative", "circulating", "CD34", "+", "cells", "count", "of", "15", "×10/L", "as", "the", "most", "frequently", "used", "criterion", "to", "discriminate", "between", "MF", "and", "other", "MPNs", "." ] } ]
PMC11767817	An ELISA-based protein panel was used to find the potential molecular targets, while flow cytometric, colorimetric, fluorescent, and luminescent assays were used to investigate the cell death mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "ELISA-based", "protein", "panel", "was", "used", "to", "find", "the", "potential", "molecular", "targets", ",", "while", "flow", "cytometric", ",", "colorimetric", ",", "fluorescent", ",", "and", "luminescent", "assays", "were", "used", "to", "investigate", "the", "cell", "death", "mechanism", "." ] } ]
PMC10976516	Ad5Δ24 and helper -dependent HDΔ28E4 PD-L1, expressing PD-L1 antibodyOnc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ad5Δ24", "and", "helper", "-dependent", "HDΔ28E4", "PD-L1", ",", "expressing", "PD-L1", "antibodyOnc", "." ] } ]
PMC10933092	Proteins were separated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (Solarbio, China) and electrotransferred to polyvinylidene difluoride membranes (Millipore, United States).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "were", "separated", "using", "sodium", "dodecyl", "sulfate-polyacrylamide", "gel", "electrophoresis", "(", "Solarbio", ",", "China", ")", "and", "electrotransferred", "to", "polyvinylidene", "difluoride", "membranes", "(", "Millipore", ",", "United", "States", ")", "." ] } ]
PMC9429973	The best response was achieved after a median of one months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "best", "response", "was", "achieved", "after", "a", "median", "of", "one", "months", "." ] } ]
PMC11802929	After removing indels using vcftools (v0.1.16) and excluding intron variants via bcftools (v1.8) the remaining exon variants were lifted to GRCh38 (hg38) using CrossMap (v0.5.2) and filtered again to remove KI27 contigs and duplicated variants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "removing", "indels", "using", "vcftools", "(", "v0.1.16", ")", "and", "excluding", "intron", "variants", "via", "bcftools", "(", "v1.8", ")", "the", "remaining", "exon", "variants", "were", "lifted", "to", "GRCh38", "(", "hg38", ")", "using", "CrossMap", "(", "v0.5.2", ")", "and", "filtered", "again", "to", "remove", "KI27", "contigs", "and", "duplicated", "variants", "." ] } ]
PMC11789597	CAV1 inhibition in MM cells significantly enhanced NK cell‐mediated MM cell killing (Figure 2D,E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAV1", "inhibition", "in", "MM", "cells", "significantly", "enhanced", "NK", "cell‐mediated", "MM", "cell", "killing", "(", "Figure", "2D", ",", "E", ")", "." ] } ]
PMC7759933	In addition to glucuronidation, sulfonation is very important in the biotransformation of xenobiotics , where sulfotransferases (SULTs) catalyse the sulfate conjugation of a variety of exogenous chemicals and endobiotics using 3′-phosphoadenosine-5′-phosphosulfate as the donor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "glucuronidation", ",", "sulfonation", "is", "very", "important", "in", "the", "biotransformation", "of", "xenobiotics", ",", "where", "sulfotransferases", "(", "SULTs", ")", "catalyse", "the", "sulfate", "conjugation", "of", "a", "variety", "of", "exogenous", "chemicals", "and", "endobiotics", "using", "3′-phosphoadenosine-5′-phosphosulfate", "as", "the", "donor", "." ] } ]
PMC3164356	Several integrin genes (e.g., ITGB3, ITGAV and ITGAM) do not show evidence of expression in the transcriptome data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "integrin", "genes", "(", "e.g.", ",", "ITGB3", ",", "ITGAV", "and", "ITGAM", ")", "do", "not", "show", "evidence", "of", "expression", "in", "the", "transcriptome", "data", "." ] } ]
PMC11291490	Consistent with the results of Gares SL et al., dusCD40L also improved the ability of the TMUV prM-E DNA vaccine to induce antigen-specific duPBMC proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consistent", "with", "the", "results", "of", "Gares", "SL", "et", "al.", ",", "dusCD40L", "also", "improved", "the", "ability", "of", "the", "TMUV", "prM-E", "DNA", "vaccine", "to", "induce", "antigen-specific", "duPBMC", "proliferation", "." ] } ]
PMC6835762	This approach towards modifying the polymer was used by Suksiriworapong et al., who reported for the first time a polymer-anticancer drug conjugate based on PGA through the successful conjugation of methotrexate (MTX), avoiding the use of intermediate linkers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "approach", "towards", "modifying", "the", "polymer", "was", "used", "by", "Suksiriworapong", "et", "al.", ",", "who", "reported", "for", "the", "first", "time", "a", "polymer-anticancer", "drug", "conjugate", "based", "on", "PGA", "through", "the", "successful", "conjugation", "of", "methotrexate", "(", "MTX", ")", ",", "avoiding", "the", "use", "of", "intermediate", "linkers", "." ] } ]
PMC11381192	To further validate the biological mechanisms between high and low CSI groups, C5 GO gene sets were downloaded from Molecular signatures Database for gene set enrichment analysis (GSEA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "validate", "the", "biological", "mechanisms", "between", "high", "and", "low", "CSI", "groups", ",", "C5", "GO", "gene", "sets", "were", "downloaded", "from", "Molecular", "signatures", "Database", "for", "gene", "set", "enrichment", "analysis", "(", "GSEA", ")", "." ] } ]
PMC11678130	Simply, upon receipt, the eggs were incubated at a temperature of 37 °C and 60% humidity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Simply", ",", "upon", "receipt", ",", "the", "eggs", "were", "incubated", "at", "a", "temperature", "of", "37", "°", "C", "and", "60", "%", "humidity", "." ] } ]
PMC9429973	MRD negativity rates for Isa-RVd vs. RVd were 49.7% (86/173) vs. 36.7% (54/147; OR=1.70, 95% CI: 1.09-2.68) in standard risk patients, 46.7% (35/75) vs. 34.7% (35/101; OR=1.65, 95% CI: 0.90-3.05) in high-risk patients and 56.3% (27/48) vs. 44.1% (15/34; OR=1.63, 95% CI: 0.67-3.99) in ultra high-risk patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MRD", "negativity", "rates", "for", "Isa-RVd", "vs.", "RVd", "were", "49.7", "%", "(", "86/173", ")", "vs.", "36.7", "%", "(", "54/147", ";", "OR=1.70", ",", "95", "%", "CI", ":", "1.09", "-", "2.68", ")", "in", "standard", "risk", "patients", ",", "46.7", "%", "(", "35/75", ")", "vs.", "34.7", "%", "(", "35/101", ";", "OR=1.65", ",", "95", "%", "CI", ":", "0.90", "-", "3.05", ")", "in", "high-risk", "patients", "and", "56.3", "%", "(", "27/48", ")", "vs.", "44.1", "%", "(", "15/34", ";", "OR=1.63", ",", "95", "%", "CI", ":", "0.67", "-", "3.99", ")", "in", "ultra", "high-risk", "patients", "." ] } ]
PMC11377827	Control vs. 14-3-3 siRNA P = 0.0043, control vs. USP43 sgRNA P < 0.0001, control vs. USP43 sgRNA + 14-3-3 siRNA **P < 0.0001, mean ± sd, one-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Control", "vs.", "14", "-", "3", "-", "3", "siRNA", "", "", "P", "=", "0.0043", ",", "control", "vs.", "USP43", "sgRNA", "", "", "", "", "P", "<", "0.0001", ",", "control", "vs.", "USP43", "sgRNA", "+", "14", "-", "3", "-", "3", "siRNA", "", "", "", "", "P", "<", "0.0001", ",", "mean", "±", "sd", ",", "one-way", "ANOVA", "." ] } ]
PMC10976516	A total of 222 patients were treated: median PFS in TG4010 patients was 5.9 months and in the placebo group 5.1 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "222", "patients", "were", "treated", ":", "median", "PFS", "in", "TG4010", "patients", "was", "5.9", "months", "and", "in", "the", "placebo", "group", "5.1", "months", "." ] } ]
PMC9509578	Cancer cells and stromal cells embedded in the extracellular matrix play a crucial role in cancer cell invasion, metastasis and drug sensitivity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "cells", "and", "stromal", "cells", "embedded", "in", "the", "extracellular", "matrix", "play", "a", "crucial", "role", "in", "cancer", "cell", "invasion", ",", "metastasis", "and", "drug", "sensitivity", "." ] } ]
PMC11513011	The limitations of this study include its limited duration and the small number of mice in the in vivo experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "limitations", "of", "this", "study", "include", "its", "limited", "duration", "and", "the", "small", "number", "of", "mice", "in", "the", "in", "vivo", "experiment", "." ] } ]
PMC11483468	Cells were treated with PBS, T-GFP or different concentrations of GST-TAT-LPTS39 protein (n=3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "treated", "with", "PBS", ",", "T-GFP", "or", "different", "concentrations", "of", "GST-TAT-LPTS39", "protein", "(", "n=3", ")", "." ] } ]
PMC11564322	It is well-known that EDPs may act through different cellular receptors, with EBPs as the major receptors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "well-known", "that", "EDPs", "may", "act", "through", "different", "cellular", "receptors", ",", "with", "EBPs", "as", "the", "major", "receptors", "." ] } ]
PMC11622247	We conclude, the markedly enhanced brightness resulting from the incorporation of light-harvesting dyes into FIT probes is anticipated to be beneficial in a multitude of application scenarios.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "conclude", ",", "the", "markedly", "enhanced", "brightness", "resulting", "from", "the", "incorporation", "of", "light-harvesting", "dyes", "into", "FIT", "probes", "is", "anticipated", "to", "be", "beneficial", "in", "a", "multitude", "of", "application", "scenarios", "." ] } ]
PMC10914904	Consequently, lysosomal pH becomes more alkaline, leading to dysfunction in lysosomal compartments .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "lysosomal", "pH", "becomes", "more", "alkaline", ",", "leading", "to", "dysfunction", "in", "lysosomal", "compartments", "." ] } ]
PMC9429973	Aims: n the present study, we aimed to explore the short-term effect of decitabine in combination with low-dose chemotherapy on improving the condition of JMML patients before HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "n", "the", "present", "study", ",", "we", "aimed", "to", "explore", "the", "short-term", "effect", "of", "decitabine", "in", "combination", "with", "low-dose", "chemotherapy", "on", "improving", "the", "condition", "of", "JMML", "patients", "before", "HSCT", "." ] } ]
PMC11487720	E FRET microscopy revealed the increased binding of EYFP-p53 with ECFP-WWOX at 4℃.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "FRET", "microscopy", "revealed", "the", "increased", "binding", "of", "EYFP-p53", "with", "ECFP-WWOX", "at", "4", "℃", "." ] } ]
PMC9429973	Methods: Studies in healthy volunteers and patients with autoimmune diseases are already completed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Studies", "in", "healthy", "volunteers", "and", "patients", "with", "autoimmune", "diseases", "are", "already", "completed", "." ] } ]
PMC11075223	Although a health product in people’s general perception, Cimicifugae Rhizoma in excess of the safe dosage may cause harm to the body.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "a", "health", "product", "in", "people", "’s", "general", "perception", ",", "Cimicifugae", "Rhizoma", "in", "excess", "of", "the", "safe", "dosage", "may", "cause", "harm", "to", "the", "body", "." ] } ]
PMC10452486	The HLA-B27-Face-3 binds to members of the killer cell receptor (KIR) and leukocyte Ig-like families (details vide infra).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "HLA-B27-Face-3", "binds", "to", "members", "of", "the", "killer", "cell", "receptor", "(", "KIR", ")", "and", "leukocyte", "Ig-like", "families", "(", "details", "vide", "infra", ")", "." ] } ]
PMC9118379	To perform explosive search on the variant spectra obtained by searching against RefP_V, we used Comet, MS-GF+, and X!Tandem to search the spectra against the SuperPep_V database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "perform", "explosive", "search", "on", "the", "variant", "spectra", "obtained", "by", "searching", "against", "RefP_V", ",", "we", "used", "Comet", ",", "MS-GF+", ",", "and", "X!Tandem", "to", "search", "the", "spectra", "against", "the", "SuperPep_V", "database", "." ] } ]
PMC7685376	This study is helpful in understanding the molecular alterations and clinical relevance of HCC after Huaier treatment, which is beneficial for finding new targets and designing effective chemotherapy regimens for the future treatment of HCC.Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors, and it is the third leading cause of cancer death.1 The therapeutic options for HCC patients are extremely limited, and one of the important reasons is that effective chemotherapy drugs are still lacking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "is", "helpful", "in", "understanding", "the", "molecular", "alterations", "and", "clinical", "relevance", "of", "HCC", "after", "Huaier", "treatment", ",", "which", "is", "beneficial", "for", "finding", "new", "targets", "and", "designing", "effective", "chemotherapy", "regimens", "for", "the", "future", "treatment", "of", "HCC.Hepatocellular", "carcinoma", "(", "HCC", ")", "is", "one", "of", "the", "most", "common", "types", "of", "malignant", "tumors", ",", "and", "it", "is", "the", "third", "leading", "cause", "of", "cancer", "death.1", "The", "therapeutic", "options", "for", "HCC", "patients", "are", "extremely", "limited", ",", "and", "one", "of", "the", "important", "reasons", "is", "that", "effective", "chemotherapy", "drugs", "are", "still", "lacking", "." ] } ]
PMC11519567	H Representative image of FRAP experiments with lentiviral SS18-EGFP or SS18-SSX1-EGFP expressed in BJ fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "H", "Representative", "image", "of", "FRAP", "experiments", "with", "lentiviral", "SS18-EGFP", "or", "SS18-SSX1-EGFP", "expressed", "in", "BJ", "fibroblasts", "." ] } ]
PMC9429973	The study was follow-up for at least half a year.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "was", "follow-up", "for", "at", "least", "half", "a", "year", "." ] } ]
PMC9429973	Around half of the study population was male, with median age of 65 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Around", "half", "of", "the", "study", "population", "was", "male", ",", "with", "median", "age", "of", "65", "years", "." ] } ]
PMC11721064	This evidence suggests that induction of LN promotes the corneal transdifferentiation of keratinocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "evidence", "suggests", "that", "induction", "of", "LN", "promotes", "the", "corneal", "transdifferentiation", "of", "keratinocytes", "." ] } ]
PMC10818573	Therefore, the first three primer pairs could be used for the PCR amplification of EBV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "first", "three", "primer", "pairs", "could", "be", "used", "for", "the", "PCR", "amplification", "of", "EBV", "." ] } ]
PMC11806182	D Scatter plot of effects of cis-eQTL SNPs on AURKA expression and UCEC occurence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Scatter", "plot", "of", "effects", "of", "cis-eQTL", "SNPs", "on", "AURKA", "expression", "and", "UCEC", "occurence", "." ] } ]
PMC11714165	The bone slices were incubated for 4 h with 200 µL solutions containing either NBD (5 µM), NBD‐F (5 µM), or DN‐F (5 µM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bone", "slices", "were", "incubated", "for", "4", "h", "with", "200", "µL", "solutions", "containing", "either", "NBD", "(", "5", "µM", ")", ",", "NBD‐F", "(", "5", "µM", ")", ",", "or", "DN‐F", "(", "5", "µM", ")", "." ] } ]
PMC11599565	These cells appeared morphologically larger compared to the surrounding cells and presented stronger pigments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cells", "appeared", "morphologically", "larger", "compared", "to", "the", "surrounding", "cells", "and", "presented", "stronger", "pigments", "." ] } ]
PMC11711871	An orally active epoxide hydrolase inhibitor was provided to salt-loaded angiotensin-infused rats that exhibited salt-sensitive hypertension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "orally", "active", "epoxide", "hydrolase", "inhibitor", "was", "provided", "to", "salt-loaded", "angiotensin-infused", "rats", "that", "exhibited", "salt-sensitive", "hypertension", "." ] } ]
PMC11395280	Cells were pre-loaded with the fluorescent calcium indicator Fluo-4AM, pre-incubated in the presence of 200 nM CCL198-83, and induced to mobilize Ca in the presence of CCL19 or CCL21 (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "pre-loaded", "with", "the", "fluorescent", "calcium", "indicator", "Fluo-4AM", ",", "pre-incubated", "in", "the", "presence", "of", "200", "nM", "CCL198", "-", "83", ",", "and", "induced", "to", "mobilize", "Ca", "in", "the", "presence", "of", "CCL19", "or", "CCL21", "(", "Figure", "2", ")", "." ] } ]
PMC9878562	VAL-ko untreated (left, plain bars) or PTX-treated (right, hatched bars) mixed with untreated VAL-wt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "VAL-ko", "untreated", "(", "left", ",", "plain", "bars", ")", "or", "PTX-treated", "(", "right", ",", "hatched", "bars", ")", "mixed", "with", "untreated", "VAL-wt", "." ] } ]
PMC9429973	Moreover, several BCL2L12 circRNAs are predicted to sponge miRNAs with a key role in AML (miR-7-5p, miR-125b-5p and miR-182-5p) and/or MDS (miR-150-5p).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "several", "BCL2L12", "circRNAs", "are", "predicted", "to", "sponge", "miRNAs", "with", "a", "key", "role", "in", "AML", "(", "miR-7", "-", "5p", ",", "miR-125b-5p", "and", "miR-182", "-", "5p", ")", "and/or", "MDS", "(", "miR-150", "-", "5p", ")", "." ] } ]
PMC9739791	Moreover, due to most photoabsorbers for Pt(IV) photoactivation being efficient PDT agents, the resulting Pt(IV) complexes could act as dual-action prodrugs, releasing Pt(II) cytostatics and generating toxic ROS under light irradiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "due", "to", "most", "photoabsorbers", "for", "Pt(IV", ")", "photoactivation", "being", "efficient", "PDT", "agents", ",", "the", "resulting", "Pt(IV", ")", "complexes", "could", "act", "as", "dual-action", "prodrugs", ",", "releasing", "Pt(II", ")", "cytostatics", "and", "generating", "toxic", "ROS", "under", "light", "irradiation", "." ] } ]
PMC9429973	The addition of venetoclax to hypomethylating agents demonstrated improved remission rates and survival; however, relapse rates are high, and most patients remain measurable residual disease (MRD) positive (DiNardo CD, N Engl J Med, 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "addition", "of", "venetoclax", "to", "hypomethylating", "agents", "demonstrated", "improved", "remission", "rates", "and", "survival", ";", "however", ",", "relapse", "rates", "are", "high", ",", "and", "most", "patients", "remain", "measurable", "residual", "disease", "(", "MRD", ")", "positive", "(", "DiNardo", "CD", ",", "N", "Engl", "J", "Med", ",", "2020", ")", "." ] } ]
PMC11518702	Recently, studies using Cre-activatable Rosa26-HGAL transgenic mouse models have provided important evidence for HGAL DLBCL driver effects (10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "studies", "using", "Cre-activatable", "Rosa26-HGAL", "transgenic", "mouse", "models", "have", "provided", "important", "evidence", "for", "HGAL", "DLBCL", "driver", "effects", "(", "10", ")", "." ] } ]
PMC11802855	The development of CXCL7-targeted therapies could open new avenues for managing myeloma and its complications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "development", "of", "CXCL7-targeted", "therapies", "could", "open", "new", "avenues", "for", "managing", "myeloma", "and", "its", "complications", "." ] } ]
PMC10523483	Therefore, it is plausible that upregulation of H1.2 in tumor is due to NRF2 activation and simultaneously becomes a part of adaptive mechanisms that counteract oxidative stress and facilitate NSCLC progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "it", "is", "plausible", "that", "upregulation", "of", "H1.2", "in", "tumor", "is", "due", "to", "NRF2", "activation", "and", "simultaneously", "becomes", "a", "part", "of", "adaptive", "mechanisms", "that", "counteract", "oxidative", "stress", "and", "facilitate", "NSCLC", "progression", "." ] } ]
PMC9429973	These findings together provide a rationale to further investigate the role of MSCs in MCL drug resistance, as understanding the role of microenvironment in venetoclax sensitivity in MCL will potentially allow for more effective and targeted therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "together", "provide", "a", "rationale", "to", "further", "investigate", "the", "role", "of", "MSCs", "in", "MCL", "drug", "resistance", ",", "as", "understanding", "the", "role", "of", "microenvironment", "in", "venetoclax", "sensitivity", "in", "MCL", "will", "potentially", "allow", "for", "more", "effective", "and", "targeted", "therapy", "." ] } ]
PMC10380508	The authors emphasized the significance of understanding the molecular pathology of RCC in guiding treatment decisions for patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "authors", "emphasized", "the", "significance", "of", "understanding", "the", "molecular", "pathology", "of", "RCC", "in", "guiding", "treatment", "decisions", "for", "patients", "." ] } ]
PMC8358006	Barplot shows the fractions of the grand H3K27me3 domains, narrow peak, and control peak among categories.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Barplot", "shows", "the", "fractions", "of", "the", "grand", "H3K27me3", "domains", ",", "narrow", "peak", ",", "and", "control", "peak", "among", "categories", "." ] } ]
PMC6835428	While CD117 targeting in vitro successfully downregulated OC cell survival , only modest effects were observed in a phase II clinical trial .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "CD117", "targeting", "in", "vitro", "successfully", "downregulated", "OC", "cell", "survival", ",", "only", "modest", "effects", "were", "observed", "in", "a", "phase", "II", "clinical", "trial", "." ] } ]
PMC10914904	Additionally, mimicking svtRNA2-1a in the neuroblastoma cell line Sh-SY5Y changed the expression of several long intergenic noncoding RNAs (lincRNAs) and protein-coding genes related to neuronal differentiation and maintenance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "mimicking", "svtRNA2", "-", "1a", "in", "the", "neuroblastoma", "cell", "line", "Sh-SY5Y", "changed", "the", "expression", "of", "several", "long", "intergenic", "noncoding", "RNAs", "(", "lincRNAs", ")", "and", "protein-coding", "genes", "related", "to", "neuronal", "differentiation", "and", "maintenance", "." ] } ]
PMC9844987	Figure 3—figure supplement 1.Levels of promoter variability are reflective of distinct biological processes.(A) Distribution of single cell adjusted variability [log10(CV)] of genes for low variable promoters (blue) and highly variable promoters (red). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "3—figure", "supplement", "1.Levels", "of", "promoter", "variability", "are", "reflective", "of", "distinct", "biological", "processes.(A", ")", "Distribution", "of", "single", "cell", "adjusted", "variability", "[", "log10(CV", ")", "]", "of", "genes", "for", "low", "variable", "promoters", "(", "blue", ")", "and", "highly", "variable", "promoters", "(", "red", ")", ".", "(" ] } ]
PMC11694066	We found that two distinct DSRCT cell lines, one newly established patient-derived xenograft (PDX)–derived organoid (PDX-O) model and one cell line–derived xenograft mouse model, were selectively sensitive to PARP inhibitors (PARPi) and ataxia–telangiectasia and Rad3–related inhibitors (ATRi).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "that", "two", "distinct", "DSRCT", "cell", "lines", ",", "one", "newly", "established", "patient-derived", "xenograft", "(PDX)–derived", "organoid", "(", "PDX-O", ")", "model", "and", "one", "cell", "line", "–", "derived", "xenograft", "mouse", "model", ",", "were", "selectively", "sensitive", "to", "PARP", "inhibitors", "(", "PARPi", ")", "and", "ataxia", "–", "telangiectasia", "and", "Rad3–related", "inhibitors", "(", "ATRi", ")", "." ] } ]
PMC10988555	Evaluation of the mitochondrial membrane potential (ΔΨM) changes in the A2780 cell line exposed to IC50 of the 2–4 complexes for 48 h by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Evaluation", "of", "the", "mitochondrial", "membrane", "potential", "(", "ΔΨM", ")", "changes", "in", "the", "A2780", "cell", "line", "exposed", "to", "IC50", "of", "the", "2–4", "complexes", "for", "48", "h", "by", "flow", "cytometry", "." ] } ]
PMC3122064	Treatment with higher Nutlin-3 concentrations led to a strong induction of p53, a further increase in Fas membrane expression and higher levels of apoptosis in cisplatin-sensitive and -resistant TC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Treatment", "with", "higher", "Nutlin-3", "concentrations", "led", "to", "a", "strong", "induction", "of", "p53", ",", "a", "further", "increase", "in", "Fas", "membrane", "expression", "and", "higher", "levels", "of", "apoptosis", "in", "cisplatin-sensitive", "and", "-resistant", "TC", "cells", "." ] } ]
PMC9429973	Viral pneumonia was diagnosed by radiological examinations in 7 (41.2%) patients, including 5 (29.4%) with severe and 2 (11.8%) with moderate COVID-19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viral", "pneumonia", "was", "diagnosed", "by", "radiological", "examinations", "in", "7", "(", "41.2", "%", ")", "patients", ",", "including", "5", "(", "29.4", "%", ")", "with", "severe", "and", "2", "(", "11.8", "%", ")", "with", "moderate", "COVID-19", "." ] } ]
PMC11596967	Due to their immense genetic diversity, microorganisms can generate a broad spectrum of peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "their", "immense", "genetic", "diversity", ",", "microorganisms", "can", "generate", "a", "broad", "spectrum", "of", "peptides", "." ] } ]
PMC11361748	Further insight gained from this RNAseq data set is reported below.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "insight", "gained", "from", "this", "RNAseq", "data", "set", "is", "reported", "below", "." ] } ]
PMC8701144	Unless otherwise stated, HEK293 cells were treated with Wnt3A CM diluted 50% in complete DMEM.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unless", "otherwise", "stated", ",", "HEK293", "cells", "were", "treated", "with", "Wnt3A", "CM", "diluted", "50", "%", "in", "complete", "DMEM", "." ] } ]
PMC10440586	Herein, we aimed to use multiomics data to demonstrate the role of CD99 in glioma adaptative responses and expand its clinical significance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Herein", ",", "we", "aimed", "to", "use", "multiomics", "data", "to", "demonstrate", "the", "role", "of", "CD99", "in", "glioma", "adaptative", "responses", "and", "expand", "its", "clinical", "significance", "." ] } ]
PMC11087301	Stem cells are classified based on their differentiation potential, with the five major types including totipotent, pluripotent, multipotent, oligopotent, and unipotent stem cells, each with varying levels of developmental plasticity and therapeutic potential .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stem", "cells", "are", "classified", "based", "on", "their", "differentiation", "potential", ",", "with", "the", "five", "major", "types", "including", "totipotent", ",", "pluripotent", ",", "multipotent", ",", "oligopotent", ",", "and", "unipotent", "stem", "cells", ",", "each", "with", "varying", "levels", "of", "developmental", "plasticity", "and", "therapeutic", "potential", "." ] } ]
PMC11506670	HCT116 and NIH3T3 cells were harvested and lysed for protein extraction 48 h post-transfection.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HCT116", "and", "NIH3T3", "cells", "were", "harvested", "and", "lysed", "for", "protein", "extraction", "48", "h", "post-transfection", "." ] } ]
PMC11269933	The full-length CDSs of CgPk and CgErk were amplified and inserted into pBiFC-VN173 and pBiFC-VC155 plasmids (MiaoLing Plasmid Platform, China; Table S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "full-length", "CDSs", "of", "CgPk", "and", "CgErk", "were", "amplified", "and", "inserted", "into", "pBiFC-VN173", "and", "pBiFC-VC155", "plasmids", "(", "MiaoLing", "Plasmid", "Platform", ",", "China", ";", "Table", "S2", ")", "." ] } ]
PMC11049294	When the individual clones (Jurkat GLA KO and mock-transfected Jurkat cells) reached to approximately 1 × 10 cells/clone, cells from the single clones were frozen and stored in 90% FBS and 10% dimethyl sulfoxide (DMSO) at −80 °C in 3 aliquots/clone.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "individual", "clones", "(", "Jurkat", "GLA", "KO", "and", "mock-transfected", "Jurkat", "cells", ")", "reached", "to", "approximately", "1", "×", "10", "cells/clone", ",", "cells", "from", "the", "single", "clones", "were", "frozen", "and", "stored", "in", "90", "%", "FBS", "and", "10", "%", "dimethyl", "sulfoxide", "(", "DMSO", ")", "at", "−80", "°", "C", "in", "3", "aliquots/clone", "." ] } ]
PMC10900886	In addition, we observed that imDCs were more susceptible and permissive to EV-D68 infection than mDCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "observed", "that", "imDCs", "were", "more", "susceptible", "and", "permissive", "to", "EV-D68", "infection", "than", "mDCs", "." ] } ]
PMC11703992	D ScPagwas TRS score of different T cell clusters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "ScPagwas", "TRS", "score", "of", "different", "T", "cell", "clusters", "." ] } ]
PMC11592837	In time-course studies on drug-treated leukemia T-cells and healthy blood cells, both markers confirmed an enhanced drug response in dividing cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "time-course", "studies", "on", "drug-treated", "leukemia", "T-cells", "and", "healthy", "blood", "cells", ",", "both", "markers", "confirmed", "an", "enhanced", "drug", "response", "in", "dividing", "cells", "." ] } ]
PMC10582049	However, several reports indicated that complement activity can be related to the better prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "several", "reports", "indicated", "that", "complement", "activity", "can", "be", "related", "to", "the", "better", "prognosis", "." ] } ]
PMC11657695	This work also focused on the regulation of KCNA2 by both chimeric proteins, EWS::FLI1 and EWS::ERG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "work", "also", "focused", "on", "the", "regulation", "of", "KCNA2", "by", "both", "chimeric", "proteins", ",", "EWS::FLI1", "and", "EWS::ERG", "." ] } ]
PMC7570809	As shown in Figure 5A, significant decrease in tumor cell invasiveness is observed when cells are treated with the RGDechi15D peptide with respect to untreated cells (control) or scrambled peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Figure", "5A", ",", "significant", "decrease", "in", "tumor", "cell", "invasiveness", "is", "observed", "when", "cells", "are", "treated", "with", "the", "RGDechi15D", "peptide", "with", "respect", "to", "untreated", "cells", "(", "control", ")", "or", "scrambled", "peptides", "." ] } ]
PMC8345486	These cell lines included commercial cell lines with differing sensitivity to platinum drugs (A2780, A2780cis, SKOV-3, and OVCAR-3) and experimental cell lines ‘not responding’ to carboplatin and highly resistant to cisplatin with an IC50 2–3 times higher than that of the parental A2780cis resistant cell line and the resistance index 9–13 with respect to the sensitive A2780 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "These", "cell", "lines", "included", "commercial", "cell", "lines", "with", "differing", "sensitivity", "to", "platinum", "drugs", "(", "A2780", ",", "A2780cis", ",", "SKOV-3", ",", "and", "OVCAR-3", ")", "and", "experimental", "cell", "lines", "‘", "not", "responding", "’", "to", "carboplatin", "and", "highly", "resistant", "to", "cisplatin", "with", "an", "IC50", "2–3", "times", "higher", "than", "that", "of", "the", "parental", "A2780cis", "resistant", "cell", "line", "and", "the", "resistance", "index", "9–13", "with", "respect", "to", "the", "sensitive", "A2780", "cell", "line", "." ] } ]
PMC11656657	High B4GALNT1 expression is often associated to tumorigenesis and both the prognosis of multiple types of tumors and the overexpression of the GD2 in tumor cells is linked to high expression of GD2-synthase enzyme .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "B4GALNT1", "expression", "is", "often", "associated", "to", "tumorigenesis", "and", "both", "the", "prognosis", "of", "multiple", "types", "of", "tumors", "and", "the", "overexpression", "of", "the", "GD2", "in", "tumor", "cells", "is", "linked", "to", "high", "expression", "of", "GD2-synthase", "enzyme", "." ] } ]
PMC9429973	Strikingly, genetic deletion of p53 in Aldh2-/- Fancd2-/- mice rescued the accelerated ageing and myeloid bias shown by both scRNAseq and transplantation of single HSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Strikingly", ",", "genetic", "deletion", "of", "p53", "in", "Aldh2-/-", "Fancd2-/-", "mice", "rescued", "the", "accelerated", "ageing", "and", "myeloid", "bias", "shown", "by", "both", "scRNAseq", "and", "transplantation", "of", "single", "HSCs", "." ] } ]
PMC8584319	Pre-treatment with refametinib or SB203580 prior to AZD8055 rescued the decrease in 4E-BP1 mRNA expression, suggesting that AZD8055-mediated down-regulation of 4E-BP1 mRNA expression is dependent on the ERK1/2 and p38 signaling pathways (Figure 6b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pre-treatment", "with", "refametinib", "or", "SB203580", "prior", "to", "AZD8055", "rescued", "the", "decrease", "in", "4E-BP1", "mRNA", "expression", ",", "suggesting", "that", "AZD8055-mediated", "down-regulation", "of", "4E-BP1", "mRNA", "expression", "is", "dependent", "on", "the", "ERK1/2", "and", "p38", "signaling", "pathways", "(", "Figure", "6b", ")", "." ] } ]
PMC8996378	The results showed that the combination of compound 44 and ABCB1 substrate chemotherapeutic drugs may help to overcome MDR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "that", "the", "combination", "of", "compound", "44", "and", "ABCB1", "substrate", "chemotherapeutic", "drugs", "may", "help", "to", "overcome", "MDR", "." ] } ]
PMC11615828	To address this, we measured the motility of LAMP1‐labeled lysosomes after nocodazole‐induced MT disassembly (Figure S10a, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "address", "this", ",", "we", "measured", "the", "motility", "of", "LAMP1‐labeled", "lysosomes", "after", "nocodazole‐induced", "MT", "disassembly", "(", "Figure", "S10a", ",", "Supporting", "Information", ")", "." ] } ]
PMC8316344	Labile iron was measured in Bel-7404 and SK-Hep1 cells under the same conditions as those in A–D. Data were analyzed by one-way ANOVA and expressed as mean ± SD from three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Labile", "iron", "was", "measured", "in", "Bel-7404", "and", "SK-Hep1", "cells", "under", "the", "same", "conditions", "as", "those", "in", "A", "–", "D.", "Data", "were", "analyzed", "by", "one-way", "ANOVA", "and", "expressed", "as", "mean", "±", "SD", "from", "three", "independent", "experiments", "." ] } ]
PMC3164356	The predicted gene models were reconciled using the GLEAN algorithm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "predicted", "gene", "models", "were", "reconciled", "using", "the", "GLEAN", "algorithm", "." ] } ]
PMC3122064	In the present study, we demonstrate that p53 resides in a complex with MDM2 at higher cisplatin concentrations in cisplatin-resistant human TC cells compared with cisplatin-sensitive TC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "the", "present", "study", ",", "we", "demonstrate", "that", "p53", "resides", "in", "a", "complex", "with", "MDM2", "at", "higher", "cisplatin", "concentrations", "in", "cisplatin-resistant", "human", "TC", "cells", "compared", "with", "cisplatin-sensitive", "TC", "cells", "." ] } ]
PMC8806312	Figure 4.Immune-related prognostic index (PI) of OS patients. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4.Immune-related", "prognostic", "index", "(", "PI", ")", "of", "OS", "patients", ".", "(" ] } ]
PMC11367146	SW982 cells (2.5 x 10 cells/well) were cultured in a 96-well plate in CO2 for 24 h. Then, cells were stimulated with IL-1β (10 ng/ml) and kept for 2 h, followed by treatment of VTE (50 & 100 μg/ml).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SW982", "cells", "(", "2.5", "x", "10", "cells/well", ")", "were", "cultured", "in", "a", "96-well", "plate", "in", "CO2", "for", "24", "h.", "Then", ",", "cells", "were", "stimulated", "with", "IL-1β", "(", "10", "ng/ml", ")", "and", "kept", "for", "2", "h", ",", "followed", "by", "treatment", "of", "VTE", "(", "50", "&", "100", "μg/ml", ")", "." ] } ]
PMC11665584	This timeline corresponds with the inflammatory and proliferative phases of wound repair (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "timeline", "corresponds", "with", "the", "inflammatory", "and", "proliferative", "phases", "of", "wound", "repair", "(", "1", ")", "." ] } ]
PMC11568601	D The apoptosis rate was significantly decreased by IRE1 knockdown and 4-PBA treatment, as determined via flow cytometry analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "The", "apoptosis", "rate", "was", "significantly", "decreased", "by", "IRE1", "knockdown", "and", "4-PBA", "treatment", ",", "as", "determined", "via", "flow", "cytometry", "analysis", "." ] } ]
PMC8567602	Since that model was described, a new subtype of BAF-family complexes was identified, which brought attention to a potential role in sarcomagenesis for all three major subtypes: GBAF (also known as ncBAF), canonical BAF (herein termed CBAF), and polybromo-BAF (PBAF, which provides a second host complex for SMARCB1; refs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "that", "model", "was", "described", ",", "a", "new", "subtype", "of", "BAF-family", "complexes", "was", "identified", ",", "which", "brought", "attention", "to", "a", "potential", "role", "in", "sarcomagenesis", "for", "all", "three", "major", "subtypes", ":", "GBAF", "(", "also", "known", "as", "ncBAF", ")", ",", "canonical", "BAF", "(", "herein", "termed", "CBAF", ")", ",", "and", "polybromo-BAF", "(", "PBAF", ",", "which", "provides", "a", "second", "host", "complex", "for", "SMARCB1", ";", "refs", "." ] } ]
PMC11656657	In the “potency co-culture assay”, CAR.GD2 and/or NT T-cells were seeded in 24-well plates at the specified E:T ratios (CAR + T: Tumor) ranging from 1:1 to 1:32.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "“", "potency", "co-culture", "assay", "”", ",", "CAR.GD2", "and/or", "NT", "T-cells", "were", "seeded", "in", "24-well", "plates", "at", "the", "specified", "E", ":", "T", "ratios", "(", "CAR", "+", "T", ":", "Tumor", ")", "ranging", "from", "1:1", "to", "1:32", "." ] } ]
PMC9429973	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]

PMC9429973

BM Tfr2 deficient mice maintained RBC count and Hb levels higher than controls until 30 weeks after FLT without any transfusion.

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PMC9429973

Approximately 50% of patients discontinued treatment; 37% had ≥4 lines of treatment and 16% had ≥5 lines.

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PMC6267596

Profile plot showed that 404 up-regulated and 605 down-regulated genes follow the same pattern across treatment vs control in all biological replicates. (

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PMC6442998

Multiple examples of drug repurposing exist in various domains, including cancer therapy and even in GIST .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiple", "examples", "of", "drug", "repurposing", "exist", "in", "various", "domains", ",", "including", "cancer", "therapy", "and", "even", "in", "GIST", "." ] } ]

PMC9429973

Aims: We aimed to identify the clinical characteristics and clinical outcome caused by CRE-BSI.

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PMC9503541

According to Worley and Powers (2012), PCA scores only show separation between groups when “within-group variation” is much less than “between-group variation” in the data, while PLS scores may show separation at random .

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PMC11026382

For the purposes of modeling, we approximated DHFR and TYMS as a two-enzyme cycle in which DHFR produces THF and consumes DHF, and TYMS produces DHF and consumes THF.

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PMC10154881

C, D) Evaluation of the antitumor effect of rMV‐SLAMblind in an immunocompetent mouse model.

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PMC11591794

With the HeLa cell line, the possible synergistic or antagonistic effects of DOX and GA on molecules that play an important role in the apoptotic signaling pathways, P53/Bax expression, and cell proliferation/migration were investigated.

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PMC11699042

Library preparation for bulk 3’-sequencing of poly(A)-RNA was performed as previously described.

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PMC9429973

Algorithms hyperparameters of ML were optimized in order to improve performance using GridSearchCV.

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PMC9429973

A recurrent thromboembolic event was found in 11% (434/3931), of these 9.7% (42/434) had elevated Hb or HCT and 18.7% (81/434) elevated Plt.

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PMC9429973

There was no significant association between efficacy of chemotherapy and other studied genotypes, namely GSTP1 C341T, MDR1 C1236T, MDR1 G2677T, MDR1 C3435T genotypes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "significant", "association", "between", "efficacy", "of", "chemotherapy", "and", "other", "studied", "genotypes", ",", "namely", "GSTP1", "C341", "T", ",", "MDR1", "C1236", "T", ",", "MDR1", "G2677", "T", ",", "MDR1", "C3435", "T", "genotypes", "." ] } ]

PMC11612315

Two-way ANOVA followed by the Bonferroni multiple comparison test (*p < 0.05, vehicle + CAP group compared with the exendin 20–29 [20 μg] group; p < 0.05, p < 0.01, vehicle + CAP group compared with the BCTC [0.5 μg] + CAP) group.

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PMC9429973

More specifically, in myelofibrosis (MF) patients (pts) it has already been reported that the number of circulating hematopoietic precursors is consistently high, with a relative circulating CD34+ cells count of 15 ×10/L as the most frequently used criterion to discriminate between MF and other MPNs.

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PMC11767817

An ELISA-based protein panel was used to find the potential molecular targets, while flow cytometric, colorimetric, fluorescent, and luminescent assays were used to investigate the cell death mechanism.

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PMC10976516

Ad5Δ24 and helper -dependent HDΔ28E4 PD-L1, expressing PD-L1 antibodyOnc.

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PMC10933092

Proteins were separated using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (Solarbio, China) and electrotransferred to polyvinylidene difluoride membranes (Millipore, United States).

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PMC9429973

The best response was achieved after a median of one months.

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PMC11802929

After removing indels using vcftools (v0.1.16) and excluding intron variants via bcftools (v1.8) the remaining exon variants were lifted to GRCh38 (hg38) using CrossMap (v0.5.2) and filtered again to remove KI27 contigs and duplicated variants.

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PMC11789597

CAV1 inhibition in MM cells significantly enhanced NK cell‐mediated MM cell killing (Figure 2D,E).

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PMC7759933

In addition to glucuronidation, sulfonation is very important in the biotransformation of xenobiotics , where sulfotransferases (SULTs) catalyse the sulfate conjugation of a variety of exogenous chemicals and endobiotics using 3′-phosphoadenosine-5′-phosphosulfate as the donor .

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PMC3164356

Several integrin genes (e.g., ITGB3, ITGAV and ITGAM) do not show evidence of expression in the transcriptome data.

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PMC11291490

Consistent with the results of Gares SL et al., dusCD40L also improved the ability of the TMUV prM-E DNA vaccine to induce antigen-specific duPBMC proliferation.

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PMC6835762

This approach towards modifying the polymer was used by Suksiriworapong et al., who reported for the first time a polymer-anticancer drug conjugate based on PGA through the successful conjugation of methotrexate (MTX), avoiding the use of intermediate linkers.

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PMC11381192

To further validate the biological mechanisms between high and low CSI groups, C5 GO gene sets were downloaded from Molecular signatures Database for gene set enrichment analysis (GSEA).

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PMC11678130

Simply, upon receipt, the eggs were incubated at a temperature of 37 °C and 60% humidity.

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PMC9429973

MRD negativity rates for Isa-RVd vs. RVd were 49.7% (86/173) vs. 36.7% (54/147; OR=1.70, 95% CI: 1.09-2.68) in standard risk patients, 46.7% (35/75) vs. 34.7% (35/101; OR=1.65, 95% CI: 0.90-3.05) in high-risk patients and 56.3% (27/48) vs. 44.1% (15/34; OR=1.63, 95% CI: 0.67-3.99) in ultra high-risk patients.

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PMC11377827

Control vs. 14-3-3 siRNA **P = 0.0043, control vs. USP43 sgRNA ****P < 0.0001, control vs. USP43 sgRNA + 14-3-3 siRNA ****P < 0.0001, mean ± sd, one-way ANOVA.

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PMC10976516

A total of 222 patients were treated: median PFS in TG4010 patients was 5.9 months and in the placebo group 5.1 months.

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PMC9509578

Cancer cells and stromal cells embedded in the extracellular matrix play a crucial role in cancer cell invasion, metastasis and drug sensitivity .

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PMC11513011

The limitations of this study include its limited duration and the small number of mice in the in vivo experiment.

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PMC11483468

Cells were treated with PBS, T-GFP or different concentrations of GST-TAT-LPTS39 protein (n=3).

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PMC11564322

It is well-known that EDPs may act through different cellular receptors, with EBPs as the major receptors .

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PMC11622247

We conclude, the markedly enhanced brightness resulting from the incorporation of light-harvesting dyes into FIT probes is anticipated to be beneficial in a multitude of application scenarios.

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PMC10914904

Consequently, lysosomal pH becomes more alkaline, leading to dysfunction in lysosomal compartments .

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PMC9429973

Aims: n the present study, we aimed to explore the short-term effect of decitabine in combination with low-dose chemotherapy on improving the condition of JMML patients before HSCT.

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PMC11487720

E FRET microscopy revealed the increased binding of EYFP-p53 with ECFP-WWOX at 4℃.

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PMC9429973

Methods: Studies in healthy volunteers and patients with autoimmune diseases are already completed.

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PMC11075223

Although a health product in people’s general perception, Cimicifugae Rhizoma in excess of the safe dosage may cause harm to the body.

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PMC10452486

The HLA-B27-Face-3 binds to members of the killer cell receptor (KIR) and leukocyte Ig-like families (details vide infra).

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PMC9118379

To perform explosive search on the variant spectra obtained by searching against RefP_V, we used Comet, MS-GF+, and X!Tandem to search the spectra against the SuperPep_V database.

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PMC7685376

This study is helpful in understanding the molecular alterations and clinical relevance of HCC after Huaier treatment, which is beneficial for finding new targets and designing effective chemotherapy regimens for the future treatment of HCC.Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors, and it is the third leading cause of cancer death.1 The therapeutic options for HCC patients are extremely limited, and one of the important reasons is that effective chemotherapy drugs are still lacking.

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PMC11519567

H Representative image of FRAP experiments with lentiviral SS18-EGFP or SS18-SSX1-EGFP expressed in BJ fibroblasts.

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PMC9429973

The study was follow-up for at least half a year.

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PMC9429973

Around half of the study population was male, with median age of 65 years.

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PMC11721064

This evidence suggests that induction of LN promotes the corneal transdifferentiation of keratinocytes.

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PMC10818573

Therefore, the first three primer pairs could be used for the PCR amplification of EBV.

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PMC11806182

D Scatter plot of effects of cis-eQTL SNPs on AURKA expression and UCEC occurence.

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PMC11714165

The bone slices were incubated for 4 h with 200 µL solutions containing either NBD (5 µM), NBD‐F (5 µM), or DN‐F (5 µM).

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PMC11599565

These cells appeared morphologically larger compared to the surrounding cells and presented stronger pigments.

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PMC11711871

An orally active epoxide hydrolase inhibitor was provided to salt-loaded angiotensin-infused rats that exhibited salt-sensitive hypertension.

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PMC11395280

Cells were pre-loaded with the fluorescent calcium indicator Fluo-4AM, pre-incubated in the presence of 200 nM CCL198-83, and induced to mobilize Ca in the presence of CCL19 or CCL21 (Figure 2).

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PMC9878562

VAL-ko untreated (left, plain bars) or PTX-treated (right, hatched bars) mixed with untreated VAL-wt.

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PMC9429973

Moreover, several BCL2L12 circRNAs are predicted to sponge miRNAs with a key role in AML (miR-7-5p, miR-125b-5p and miR-182-5p) and/or MDS (miR-150-5p).

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PMC9739791

Moreover, due to most photoabsorbers for Pt(IV) photoactivation being efficient PDT agents, the resulting Pt(IV) complexes could act as dual-action prodrugs, releasing Pt(II) cytostatics and generating toxic ROS under light irradiation.

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PMC9429973

The addition of venetoclax to hypomethylating agents demonstrated improved remission rates and survival; however, relapse rates are high, and most patients remain measurable residual disease (MRD) positive (DiNardo CD, N Engl J Med, 2020).

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PMC11518702

Recently, studies using Cre-activatable Rosa26-HGAL transgenic mouse models have provided important evidence for HGAL DLBCL driver effects (10).

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PMC11802855

The development of CXCL7-targeted therapies could open new avenues for managing myeloma and its complications.

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PMC10523483

Therefore, it is plausible that upregulation of H1.2 in tumor is due to NRF2 activation and simultaneously becomes a part of adaptive mechanisms that counteract oxidative stress and facilitate NSCLC progression.

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PMC9429973

These findings together provide a rationale to further investigate the role of MSCs in MCL drug resistance, as understanding the role of microenvironment in venetoclax sensitivity in MCL will potentially allow for more effective and targeted therapy.

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PMC10380508

The authors emphasized the significance of understanding the molecular pathology of RCC in guiding treatment decisions for patients .

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PMC8358006

Barplot shows the fractions of the grand H3K27me3 domains, narrow peak, and control peak among categories.

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PMC6835428

While CD117 targeting in vitro successfully downregulated OC cell survival , only modest effects were observed in a phase II clinical trial .

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PMC10914904

Additionally, mimicking svtRNA2-1a in the neuroblastoma cell line Sh-SY5Y changed the expression of several long intergenic noncoding RNAs (lincRNAs) and protein-coding genes related to neuronal differentiation and maintenance .

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PMC9844987

Figure 3—figure supplement 1.Levels of promoter variability are reflective of distinct biological processes.(A) Distribution of single cell adjusted variability [log10(CV)] of genes for low variable promoters (blue) and highly variable promoters (red). (

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PMC11694066

We found that two distinct DSRCT cell lines, one newly established patient-derived xenograft (PDX)–derived organoid (PDX-O) model and one cell line–derived xenograft mouse model, were selectively sensitive to PARP inhibitors (PARPi) and ataxia–telangiectasia and Rad3–related inhibitors (ATRi).

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PMC10988555

Evaluation of the mitochondrial membrane potential (ΔΨM) changes in the A2780 cell line exposed to IC50 of the 2–4 complexes for 48 h by flow cytometry.

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PMC3122064

Treatment with higher Nutlin-3 concentrations led to a strong induction of p53, a further increase in Fas membrane expression and higher levels of apoptosis in cisplatin-sensitive and -resistant TC cells.

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PMC9429973

Viral pneumonia was diagnosed by radiological examinations in 7 (41.2%) patients, including 5 (29.4%) with severe and 2 (11.8%) with moderate COVID-19.

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PMC11596967

Due to their immense genetic diversity, microorganisms can generate a broad spectrum of peptides.

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PMC11361748

Further insight gained from this RNAseq data set is reported below.

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PMC8701144

Unless otherwise stated, HEK293 cells were treated with Wnt3A CM diluted 50% in complete DMEM.

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PMC10440586

Herein, we aimed to use multiomics data to demonstrate the role of CD99 in glioma adaptative responses and expand its clinical significance.

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PMC11087301

Stem cells are classified based on their differentiation potential, with the five major types including totipotent, pluripotent, multipotent, oligopotent, and unipotent stem cells, each with varying levels of developmental plasticity and therapeutic potential .

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PMC11506670

HCT116 and NIH3T3 cells were harvested and lysed for protein extraction 48 h post-transfection.

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PMC11269933

The full-length CDSs of CgPk and CgErk were amplified and inserted into pBiFC-VN173 and pBiFC-VC155 plasmids (MiaoLing Plasmid Platform, China; Table S2).

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PMC11049294

When the individual clones (Jurkat GLA KO and mock-transfected Jurkat cells) reached to approximately 1 × 10 cells/clone, cells from the single clones were frozen and stored in 90% FBS and 10% dimethyl sulfoxide (DMSO) at −80 °C in 3 aliquots/clone.

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PMC10900886

In addition, we observed that imDCs were more susceptible and permissive to EV-D68 infection than mDCs.

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PMC11703992

D ScPagwas TRS score of different T cell clusters.

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PMC11592837

In time-course studies on drug-treated leukemia T-cells and healthy blood cells, both markers confirmed an enhanced drug response in dividing cells.

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PMC10582049

However, several reports indicated that complement activity can be related to the better prognosis.

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PMC11657695

This work also focused on the regulation of KCNA2 by both chimeric proteins, EWS::FLI1 and EWS::ERG.

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PMC7570809

As shown in Figure 5A, significant decrease in tumor cell invasiveness is observed when cells are treated with the RGDechi15D peptide with respect to untreated cells (control) or scrambled peptides.

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PMC8345486

These cell lines included commercial cell lines with differing sensitivity to platinum drugs (A2780, A2780cis, SKOV-3, and OVCAR-3) and experimental cell lines ‘not responding’ to carboplatin and highly resistant to cisplatin with an IC50 2–3 times higher than that of the parental A2780cis resistant cell line and the resistance index 9–13 with respect to the sensitive A2780 cell line.

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PMC11656657

High B4GALNT1 expression is often associated to tumorigenesis and both the prognosis of multiple types of tumors and the overexpression of the GD2 in tumor cells is linked to high expression of GD2-synthase enzyme .

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PMC9429973

Strikingly, genetic deletion of p53 in Aldh2-/- Fancd2-/- mice rescued the accelerated ageing and myeloid bias shown by both scRNAseq and transplantation of single HSCs.

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PMC8584319

Pre-treatment with refametinib or SB203580 prior to AZD8055 rescued the decrease in 4E-BP1 mRNA expression, suggesting that AZD8055-mediated down-regulation of 4E-BP1 mRNA expression is dependent on the ERK1/2 and p38 signaling pathways (Figure 6b).

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PMC8996378

The results showed that the combination of compound 44 and ABCB1 substrate chemotherapeutic drugs may help to overcome MDR.

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PMC11615828

To address this, we measured the motility of LAMP1‐labeled lysosomes after nocodazole‐induced MT disassembly (Figure S10a, Supporting Information).

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PMC8316344

Labile iron was measured in Bel-7404 and SK-Hep1 cells under the same conditions as those in A–D. Data were analyzed by one-way ANOVA and expressed as mean ± SD from three independent experiments.

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PMC3164356

The predicted gene models were reconciled using the GLEAN algorithm.

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PMC3122064

In the present study, we demonstrate that p53 resides in a complex with MDM2 at higher cisplatin concentrations in cisplatin-resistant human TC cells compared with cisplatin-sensitive TC cells.

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PMC8806312

Figure 4.Immune-related prognostic index (PI) of OS patients. (

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PMC11367146

SW982 cells (2.5 x 10 cells/well) were cultured in a 96-well plate in CO2 for 24 h. Then, cells were stimulated with IL-1β (10 ng/ml) and kept for 2 h, followed by treatment of VTE (50 & 100 μg/ml).

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PMC11665584

This timeline corresponds with the inflammatory and proliferative phases of wound repair (1).

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PMC11568601

D The apoptosis rate was significantly decreased by IRE1 knockdown and 4-PBA treatment, as determined via flow cytometry analysis.

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PMC8567602

Since that model was described, a new subtype of BAF-family complexes was identified, which brought attention to a potential role in sarcomagenesis for all three major subtypes: GBAF (also known as ncBAF), canonical BAF (herein termed CBAF), and polybromo-BAF (PBAF, which provides a second host complex for SMARCB1; refs.

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PMC11656657

In the “potency co-culture assay”, CAR.GD2 and/or NT T-cells were seeded in 24-well plates at the specified E:T ratios (CAR + T: Tumor) ranging from 1:1 to 1:32.

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PMC9429973

.

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