Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11750712
Staining for CCR7 was carried out before surface staining at 37 °C for 15 min (BioLegend).
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PMC11791432
The mice were mercifully euthanized during 4 to 10 weeks after the appearance of neurological symptoms.
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PMC11087055
Further, a single axis-inducing morphogen, Vg1, is capable of inducing the bilateral rotating cell flow even under mitotic arrest, when the ectopic PS is reduced (Figure 5B and C).
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PMC11794568
Melanoma, as one of the deadliest types of skin cancer, its malignant progression poses a great threat to human health.
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PMC9080589
Furthermore, mounting evidence indicates that autophagy is correlated with the process of cancer cell apoptosis.
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PMC9429973
Apoptosis of HEL 92.1.7 cells was slightly affected by BMP2 and LDN-193189.
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PMC7022782
For each sample were performed eight replicates.
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PMC11694066
We next assessed downstream CCL5 and CXCL10 expression levels by RT-qPCR and found that these chemokines were increased by more than 20-fold and 5-fold, respectively (Fig. 6B and C) upon combination therapy.
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PMC9429973
Summary/Conclusion: The real-world data from our cohort of hard-to-treat and aggressive R/R DLBCL showed the Pola-BR combination is a promising treatment option with a manageable toxicity profile.
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PMC11564405
B The infiltration density of CD8 + T cells in the low RILPL2 expression group and high RILPL2 expression group The correlation between RILPL2 expression and CD4 + T cell infiltration in 140 patients with primary NSCLC Data were analyzed using the chi-square test The correlation between RILPL2 expression and CD4 + T cell infiltration in 66 patients with LUAD Data were analyzed using the chi-square test The correlation between RILPL2 expression and CD4 + T cell infiltration in 74 patients with LUSC Data were analyzed using the chi-square test The correlation between RILPL2 expression and CD8 + T cell infiltration in 140 patients with primary NSCLC Data were analyzed using the chi-square test By strategically utilizing the TISIDB database, our research was directed towards comprehensively exploring the intricate link between RILPL2 expression levels and the expression profiles of genes exclusively associated with chemokines in the complex environment of NSCLC, which was facilitated by the rich data repository of TISIDB, which not only broadened our understanding of the immune-genome landscape, but also revealed potential avenues for targeted interventions in the intricate pathological network of NSCLC.
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PMC11617590
Because SFN induces the inactivation of GSK‐3β, we evaluated the expression of NF‐κB. Treatment of 100 μM SFN for 24 h significantly decreased the expression of the p65 subunit of NF‐κB from 1.00 ± 0.06 to 0.70 ± 0.03 (**p < 0.01), while the expression of the other NF‐κB subunit p50 was unaffected (0 μM SFN 1.00 ± 0.01; 100 μM SFN 1.05 ± 0.03).
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PMC11760643
Immunolabelling with this mAb and flow cytometry revealed that relative amounts of cell surface P2X7 varied between human peripheral blood leukocytes.
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PMC11453018
Data were normalized to B2M and are presented as fold change compared to the control group.
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PMC11718817
During apoptosis, caspases-3 and -7 are activated, cleaving the DEVD peptide, thereby enabling the dye to bind DNA and resulting in fluorescence.
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PMC10965680
This led us to identify 716 genes as the top 5% of genes showing positive selection.
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PMC11699465
Then, cell lysates were incubated with 1μg of antibody and Protein G and A Dynabeads (Thermo Fisher) overnight at 4°C.
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PMC11684269
In addition, TEPP-46 can inhibit the differentiation of Th17, as well as Treg, independent of PKM2 and its metabolic function, via hindering Smad2/Smad3 signaling pathway activated by TGF-β (34).
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PMC8973085
Found: C, 62.30; H, 4.12; N, 12.15.
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PMC9024365
The knockdown of SD1 results in a decrease in the number and strength of excitatory synapses.
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PMC7582629
Raman scattering, discovered by Sir C.V. Raman and K.S. Krishnan in 1928, refers to the scattering of light from a molecular or cellular sample that exhibits a frequency shift (inelastic scattering).
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PMC3888431
The DNA library was amplified by emulsion PCR and sequenced on the GS FLX system using Titanium sequencing chemistry according to the manufacturer’s instructions over one sequencing plate (Roche Applied Sciences, Mannheim, Germany).
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PMC9352806
Stock solution of BMS was prepared in ethanol at 10 mg/mL and stored at −20 °C.
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PMC10114490
C AAT secretion was estimated from 24-h cell media using an ELISA kit.
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PMC9592219
The snap-frozen tumor tissues collected from cohort 2 were subjected to quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis.
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PMC10165258
After his oil exchange, the smaller droplets fused into a single larger droplet when bathing in the PFO solution for 1 to 3 min (Figures 2B and 2C).
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PMC9429973
Regarding HMA therapy, 67% received HMA monotherapy and 33% received HMA in combination with various agents.
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PMC3888431
The pipeline chooses the best result from each tool (e.g. based on e-value and score for BLAST results, cutoff 10) and assigns a confidence value based on the quality of the result.
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PMC2193049
In this context, it is noteworthy that the protein MAGE-3 contains, in addition to the poorly presented peptide studied here, other antigenic peptides which are well presented by MAGE-3 melanoma cells in association with HLA-A1 or HLA-B44 molecules (15, 16).
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PMC11106977
In the cells tested, three different transcripts are produced by alternative gene splicing, and these transcripts encode a nucleocytoplasmic isoform (ncOGT, 116 kDa), a mitochondrial isoform (mOGT, 103 kDa), and a short isoform (sOGT, 75 kDa).
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PMC11765243
Th1 differentiation was carried out for 72 h in the presence of anti-CD28 antibody (2.5 µg/mL), anti-IL-4 (5 µg/mL), and IL-12 (20 ng/mL).
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PMC11694625
All in all.
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PMC10421378
The results obtained by counting visible colonies were considered statistically significant only for plates with dilution samples for which the number of colonies ranged from 30 to 300.
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PMC11507371
Having examined the translocation dynamics of these pathways, we elucidated whether subsequent target genes are activated.
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PMC11604830
Values of proton concentrations, and longitudinal and transversal relaxation times (measured at 298 K and 310 K) determined for each nanosystem at 14T.
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PMC5874706
Further studies should be investigated to optimize the drug-loading capacity of our amphiphilic α-cyclodextrin-based nanoparticles.
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PMC11699042
They additionally verified their findings in a panel of adult carcinoma cell lines including (except for a single pediatric hepatoblastoma cell line HepG2-A) mostly adult-type carcinoma cell lines, all of which are not driven by a single mutation, such as the chimeric oncogenic transcription factor (COTF) found in EwS. In this study, we hypothesize that oligo-mutated pediatric sarcoma cell lines driven by a COTF, such as Ewing sarcoma (EwS) are genetically and phenotypically more stable than the previously investigated adult carcinoma cell lines.
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PMC11306331
Data were fit to the generalized logistic function to calculate a decay rate.
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PMC11731161
Despite significant progress has been made in the treatment of myeloma, inherent and acquired drug resistance remains a major limitation for long-term disease control .
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PMC10926885
Deep deletions were the sort of genetic mutation that happened the least often in NDE1, as shown in Figure 3B, happening only in BLCA, OV, LUAD and LUSC.
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PMC10142392
Furthermore, they compared the effect of the degree of branching of the PCL halves on micelle stability.
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PMC11352877
The ratio of VEGF-A to HIF-1α was significantly elevated in HME1 compared to 12Z (p = 0.0002), to A2780 (p = 0.0149; 95.00% CI with a difference range of 0.1657 to 2.159), to RL-95-2 (p < 00001; 95.00% CI with a difference range of 1.095 to 3.089), and also to SK-UT-1 (p = 0.0012) (Figure 5B).
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PMC11628904
However, we found no difference in the amount of apoptotic cells between control and isotonic treated fish (Figure S1).
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PMC11387401
7SL RNA is part of the signal recognition particle (SRP) ribonucleoprotein complex that direct mRNA translation through transmembrane pores.
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PMC11767725
Recent murine experiments have shown that injecting bacteriophages targeting C. acnes can reduce inflammatory nodules and epidermal thickening in mice, supporting the therapeutic potential of phages as an alternative or complement to antibiotics—especially given growing antibiotic resistance.
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PMC11594641
The cells were lysed with RIPA buffer (Sigma Aldrich, St. Louis, MO, USA) supplemented with protease inhibitor tablets (Roche Diagnostics GmbH) for 30 min on ice, followed by centrifugation for 15 min at 14,000× g at 4 °C.
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PMC6643347
The other two resin acids had the gross formula of .
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PMC11766174
This highlights the need for simpler, less expensive, and time-saving methods to reliably measure the HIV reservoir size.
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PMC11635087
Therefore, the φII of the chloroplasts in CHO-K1 cells was calculated using the following equation: φII=((Fm′−F)−(Fm′n−Fn))/(Fm′−Fm′n) We also measured samples of isolated chloroplasts only to obtain the Fv/Fm and φII.
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PMC11457557
Due to the enormous price and time required to sequence substantial parts of the genome, this technology is currently impracticable.
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PMC10761218
The plant materials were collected in the months of July–October 2022, during the monsoon season.
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PMC11423992
B-cell lymphoma, clinically, comprises a heterogeneous group of malignancies that encompass various subtypes.
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PMC11657744
These findings highlight the distinct roles of CEP89 and FBF1 in ciliary dynamics through regulating AurA kinase.
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PMC11365427
Suppressing the expression of the glutamine transporter ASCT2 or the glutamine synthesis enzyme GLS1 is a novel strategy for MM treatment.
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PMC9444294
As all samples had confirmed SS18 gene rearrangements during their original diagnostic work-up, we sought to validate the presence of SS18-SSX fusion transcripts in the IHC-negative cases.
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PMC4005030
Hibiscus PCA supplementation was found to be beneficial in enhancing antioxidant status and inhibiting oxidative stress induced by exhaustive exercise in skeletal muscles.
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PMC11626627
Tumor volumes of each group were measured in situ for 4 weeks post-injection.
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PMC11319300
Sequence conservation was not only seen in closely related species, such as chimpanzee and gorilla, but also in more distantly related species like squirrel monkeys (Supplementary Figure S5).
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PMC11711871
Glucocorticoid excess in Cushing syndrome or glucocorticoid resistance in certain GR mutations induced hypertension and affected renal sodium retention .
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PMC11720107
The media used in the experiments were phenol red-free and contained 2.5 mM L-glutamine.
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PMC11519788
All participants provided the informed consent.
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PMC7215722
Therefore, we chose short labeling time points to detect early forms of DPPIV in the ER and chase these forms to maturation through the Golgi apparatus.
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PMC11697703
ANOVA-Tukey was used to determine significant differences for Sholl analysis.
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PMC11746948
One week after the injection of AOM, the normal drinking water in the cages was replaced with 2% dextran sodium sulfate (DSS) (MP biomedical) for one week, followed by two weeks of normal drinking water, which was referred to as one DSS cycle.
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PMC11489351
This includes TFs with expression that is upregulated at high pHi compared to low pHi (BTG2, E2F7, NOTCH1, TCF19, TP73, and ZNF488) as well as TFs with expression that is downregulated at high pHi compared to low pHi (e.g., BEND6, signal transducer and activator of transcription 4, and TEF).
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PMC11240448
These unbiased assumptions are logical and justified, if there is no a priori knowledge about cell features.
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PMC7039683
In stable transgenic lines, GFP expression was detectable in the enveloping layer by shield stage (Figure 4—figure supplement 1B–E) and in periderm until at least five dpf (Figure 4E); it was also evident in pharyngeal epithelium at this stage (Figure 4—figure supplement 1F and F').
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PMC11536589
Parental AsPC1 cells, AsPC1 cells treated with 1 µM MRTX1133 for 48 h (AsPC1-D2), and AsPC1-MR cells were cultured in triplicate in 10 cm dishes.
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PMC11397654
The activity was assessed as the ratio of surface calreticulin (CRT) positive cells, as surface-exposed pre-apoptotic CRT is one of the typical damage-associated molecular patterns connected with ICD inducing.
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PMC10999934
The expression of overlapping genes in TCGA-OV dataset. (
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PMC10047551
However, PD-L1 mRNA expression was not concomitantly increased (Figure 3C).
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PMC9429973
This corresponds to a positive genetic result found in 30% of pts referred with MDS/AML, 33% of pts referred with a lymphoid malignancy, and 18% of pts referred with bone marrow failure, MPN, or other HD.
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PMC11782508
Cell cycle distribution of control and azurin-treated cells.
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PMC11687663
Additionally, from precursor ions at m/z 290 and 472 suggests natural product, indicating the presence of Angiopteroside and Corosolic acid (Table 1).
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PMC11756514
Bacterial strains used in this study.
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PMC10965315
Treating cells with 150 μM of harmaline caused a significant increase in the rate of apoptotic cells in both the late apoptotic phase (36.8%) and the necrotic phase (40.5%).
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PMC9429973
These associations were especially strong in the ABC subtype, where DEK expression also correlated with poor prognosis markers and was an independent predictor of treatment response.
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PMC11322866
Subsequently, the proteins were subjected to sodium dodecyl sulfate‒polyacrylamide gel electrophoresis (SDS-PAGE) and transferred onto nitrocellulose membranes.
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PMC11525028
n = 5 per group).(I) Body weight of the PDX model treated with paliperidone, AG-401, or combination (n = 5 per group).(J) Representative IHC images showing the expression of NAT10, ATF4, ASNS, and Ki-67 in the PDX model.
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PMC9429973
Investigating dependencies of ALL cells on BCL-2 family proteins by dynamic BH3 profiling, we found a shift towards MCL-1-dependence upon exposure to AZD4320, while AZD5991 induced an increased combined dependence on BCL-2 and BCL-XL, indicating potential synergistic activity of triple inhibition.
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PMC9841531
Mean ± SEM values of at least three independent experiments are shown.
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PMC11490153
Component identification was achieved by comparing acquired spectra with reference databases and library information .
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PMC10812665
This is in line with previous observations and it also shows that the toxicants may affect microtubules in different ways and via different mechanisms .
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PMC9429973
Toxicity during CART1 was substantial, with ASTCT grade III CRS, grade I ICANS, and prolonged cytopenia (ANC <500/µl at day 90).
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PMC3675084
β-actin was loading control. (
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PMC6600592
ESIMS: m/z 306.1701 [M + H], 328.1521 [M + Na], calculated for C17H23NO4 (305.37).
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PMC11806182
Functional enrichment analysis terms are annotated around the bars, with numbers in parentheses indicating the statistical significance of the enrichment In this study, we performed an integrative analysis to investigate the role of miRNAs in linking PCOS with UCEC, identifying several miRNAs as potential biomarkers and therapeutic targets.
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PMC11736898
Treatment of normal or keloid keratinocytes with vitamin D significantly reduced expression of FZD7 (Figure 7f).
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PMC11049548
As an example, some of us characterized the cellular effects induced in A2780 cells and A2780cis cells by treatment with the three clinically established platinum drugs, i.e., cisplatin, carboplatin, and oxaliplatin .
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PMC9727330
Also, ASNS depletion has been reported to inhibit the panel of breast cancer, prostate cancer, and melanoma cell profanation (Pathria et al., 2019).
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PMC10114490
D Table containing the most significant (FDR > 0.05) signature gene sets determined by GSEA using C8 MSigDB cell types signature gene sets (https://www.gsea-msigdb.org/gsea/msigdb/genesets.jsp?collection=C8).
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PMC11674891
RNA sequencing and gene set enrichment analysis (GSEA) identified an enrichment of metastasis-promoting genes in GRPR-overexpressing cells, with CRABP2 and FNDC4 emerging as key targets.
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PMC11798926
Coverslips were washed with PBST (0.01% Triton in PBS) and incubated with blocking solution at RT for 2 h. The antibodies against PSD95 (UC Davis/NIH NeuroMab Facility Cat# K28/43, RRID: AB_2877189) and FLAG (Sigma-Aldrich Cat# F3165, RRID: AB_259529) were added to the neurons at 4°C overnight.
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PMC9583612
Each site had 3–4 sensors depending on the size of the facility, the number of equipment with the potential to emit methane, and the prevailing wind direction and local geography.
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PMC11323699
This approach may overlook the crucial role of the CD47/TSP-1 axis in the anti-cancer immune response.
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PMC11332076
In the present study, we generated constitutively active insulin receptor (F-iIR) and insulin-like growth factor-1 receptor (F-iIGF1R) using a system that forces membrane localization of the intracellular domains of these receptors by farnesylation.
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PMC11678368
The compound cis-[PtCl2(NH3)2] (cisplatin) exhibits the highest selectivity for the A2780 cell line (SI = 4.27), suggesting significant effectiveness in treating this cancer type while minimizing toxicity to normal cells.
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PMC11089031
superscript a, b: The same letters indicates there is no difference between sub-group (P > 0.05) and the different letters indicated there is significant difference between sub-group (P < 0.05) Groups of statistically significant differences were shown in bold The results of statistical analysis of the expression levels of ZNF692 in ccRCC by IHC N.S.: No statistical significance (P > 0.05); Non: Unable to perform statistical analysis for the small number of samples.
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PMC11747885
Interestingly, cells treated solely with 1 and 26 showed reduced viability, as previously demonstrated, but maintained an RNA integrity level above the threshold of 2 (Fig. 4C and S7C†).
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PMC8751435
Additionally, caspase‐3‐dependent apoptosis accounts for few percentages in CME‐induced cell death in 24‐h exposure.
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PMC11746948
In this study, we demonstrate that GPX4 is reversibly palmitoylated on cysteine 66, catalyzed by ZDHHC20 and APT2, respectively.
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