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PMC10958426
Wilcoxon signed rank test were performed to examine whether the number of detected genes is significantly different between cancer cells and epithelial cells. (
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PMC11240571
In vivo, exosomes were extracted from serum using blood collected from mice.
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PMC11740907
The peak of the curve is around −0.32 cm/Vs which indicates the average mobility (C).
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PMC11756937
In the stem cell biology field, there is a well-established preference for non-integrating reprogramming methods over lentiviral and retroviral approaches due to their reduced risk of genomic integration ; however, a comprehensive investigation of non-integrating methods from a biobanking perspective is currently lacking.
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PMC9429973
Bleeding severity is unpredictable in GT.
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PMC11796104
The major histocompatibility complex in humans, known as HLA region, is the most polymorphic human genetic system and it is known as a cluster of genetic markers, associated with several diseases.
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PMC11307990
6HB-DONs were designed and assembled according to Rothemund’s and Yan’s methods.
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PMC11680049
These polyphenol hyperaccumulator zones correspond to the structures that determine the hydraulic capacity of Sequoia plant tissues, influencing their ability to keep stomata open longer.
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PMC4485648
HIF-1 trans-activates a multitude of genes mediating adaptive responses to hypoxia.
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PMC11401350
G Three days post-transduction T cells were surface stained for CD8 and hCD34 followed by staining for CD69.
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PMC11555465
After washing twice with PBS, the 6-well plates were observed under a fluorescence microscope and images were captured to record the scratch width at 0 h. The control group cells were added to 2 ml serum-free culture medium, while the experimental group cells were added to 2 ml T. gondii tachyzoite culture supernatant at 37°C in a 5% CO2 atmosphere.
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PMC11720107
Additionally, the media were supplemented with 10% FBS, and for SCC-15 cells, 400 ng/mL hydrocortisone was also included.
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PMC11721587
S2R cells were seeded in 12-well plate at the concentration of 1 × 10/ml, and, the next day, each well was transfected with 0.5 μg of ptc-Luc reporter construct, 25 ng of RL-PolIII Renilla internal control construct, and 0.5 μg each of the other constructs.
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PMC9429973
Automated LIC results from the DLA R2-MRI had geometric mean ratios to manual results from SDPA R2-MRI of 0.98 (95% CI 0.94 – 1.01) below 3 mg Fe/g dry tissue and 0.93 (95% CI 0.92 – 0.95) above 3mg Fe/g dry tissue were recorded.
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PMC11001582
d, Live-cell Incucyte confluency quantification in (GR)50, or GFP-treated iNeurons.
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PMC9878562
All cells expressed similar levels of CXCR4 on the plasma membrane ( Figure 1A ).
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PMC11742431
In this study, we engineered BumPeD, a novel bispecific nanobody‐targeted PROTACs‐like platform, by fusing two nanobodies with a Furin protease cleavage site (RVRR) and a degron sequence (ALAPYIP or KIGLGRQKPPKATK), enabling the tumor microenvironment to direct the degradation of intracellular proteins.
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PMC11802855
Tumor growth and development were monitored regularly throughout the experiment.
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PMC11640555
After 24 h of the treatment, cells were rinsed carefully with PBS; subsequently, basal medium with FBS 10% was added, and cells were incubated for 10 days (with a basal medium change enriched with FBS 10%, three times a week).
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PMC4112127
Five malignant biliary cancer cell lines were used in this study, KMC-1 (derived from an ICC), KMCH-1 (derived from a mixed hepatocellular carcinoma (HCC)/CC, but having a primarily biliary phenotype), KMBC and OZ (derived from ECCs), and Mz-ChA-1 (derived from a gallbladder adenocarcinoma) [31-35].
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PMC11576293
The enzyme assay revealed that the six hybrids studied significantly inhibited VEGFR-2, with IC50 values ranging from 1.15 to 2.95 nM (Table 3).
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PMC9429973
For cultivation, a nutrient medium based on methylcellulose (MethoCult Human No. 4434, StemCell Technologies, Canada) was used, inoculation was performed according to the standard method.
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PMC11792090
Subsequently, we performed a triple knockout (tKO) of TRAC, B2M, and HLA-DRA in CD70 CAR-T cells to generate CD70 UCAR-T cells, achieving knockout efficiencies of over 80% for each gene ( Figure 2B ).
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PMC11352746
Molecular Devices’ ImageXpress Pico (Molecular Devices LLC.,
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PMC11297139
Source data are provided as a Source Data file.
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PMC11547972
This accords with data from Gokay et al. reporting an IC50 of 15–20 µM SFN being necessary to significantly block RCC cell growth .
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PMC9878562
For VAL-wt, in a 1:1 mixture with VAL-ko, 233 tracklets displayed low arrest coefficients and low directionality, which indicates that these cells perform chemokinesis (green gate), whereas 511 tracklets were associated with immobile cells, characterized by tracklets with a high arrest coefficient and low directionality (blue gate).
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PMC11001582
We did not observe astrogliosis or microgliosis in the motor cortex of (GR)400 and (PR)400 mice up to 12 months of age (Extended Data Fig. 3a,c).
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PMC11222184
MAP2K3 has been described as an oncogene whose elimination decreases tumor development and increases biological responsiveness to chemotherapy .
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PMC9275501
Carrier-free NDCDS can improve drug loading, drug stability, and bioavailability, and increase drug safety, so as to achieve high flexibility in drug response release and synergistic combination therapy (Huang et al., 2021; Karaosmanoglu et al., 2021).
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PMC9412887
Lastly, DOX was loaded into pPGNCs to obtain DOX@pPGNCs with a diameter of ~160 nm and a zeta potential of approximately −20 mV. As shown in Figure 3b, PMEO2MA-OEGMA was thermosensitive with a lower critical solution temperature of ca.
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PMC11747467
Consistent with this, ERBB2 expression mediates the sensitivity of bladder cancer cells to RC48.
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PMC11264242
This mutation is created by the fusion of two separate genes, namely, SS18 and SSX, through chromosomal translocation (Crew et al., 1995).
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PMC11572213
Loss of TET2 function models have shown that TET2 plays a role in the regulation of myeloid progenitor cell proliferation and differentiation.
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PMC7823217
Transforming Growth Factor-β (TGF-β) induced (EMT) in an advanced bioprinted cervical tumor model shows promising results for developing future therapeutic strategies towards preventing or treating cervical tumor metastasis.
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PMC11075223
In a 13-week subchronic toxicity and genotoxicity study, C. heracleifolia extract (667, 2000 mg/kg) increased serum alanine transaminase activity and liver weights in female rats without effects on male .
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PMC11679033
The collection of personal data and blood samples for the experiment was approved by the Ethics Committee of the Institute for Medical Research and Occupational Health, Zagreb, Croatia (Class: 01-18/23-02-2/1; Reg.
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PMC9596868
Scale bars indicate 10 μm.
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PMC11527437
This finding is important because targeted mass spectrometry revealed that the decamer was more abundantly presented than the nonamer at the surface of the cancer cell lines tested, suggesting that TCRs targeting the decamer KRAS G12V peptide may be more effective than nonamer targeting TCRs due to a higher density of target antigen.
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PMC9429973
Brusatol induced a higher reduction of cell viability in PBMCs from advanced disease patients (Binet C).
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PMC9429973
The OS at 2 years of the patients who did not develop cGVHD (n= 32) was 58% (95% CI 56-60) of those with a mild cGVHD (n=10) was 85% (95% CI 83-87) of those with a moderate cGVHD (n=15) was 79% (95% CI 77-81) and of those who develop a severe cGVHD (n=9) was 64% (95% CI 61-67).
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PMC9429973
In vivo treatment of Calr mice with bortezomib resulted in a significant reduction in platelets.
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PMC11711063
Target proteins were detected on 10% PAGE using primary antibodies in 5% BSA‐TBST.
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PMC11344246
For subsequent quantification of organoid morphology, including area, radius, and eccentricity, as well as texture and intensity features, we used well-level data, including mean, median, and standard deviation.
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PMC11617590
Roy et al. demonstrated that SFN induces cell cycle arrest and apoptosis through the regulation of FOXO transcription factors.
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PMC3765139
In addition, nearly 2% of the Me39 cells (Figure 1B), more than 3% of RE cells (Figure 1C), and more than 1% of Na8 (Figure 1D) and Me59 (Figure 1E) cells also expressed CD133.
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PMC11476222
These molecules are involved in key physiological processes such as cell growth, viral transformation, and tumor progression, making them potential targets for cancer immunotherapy and molecular characterization .
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PMC11540664
Kaplan–Meier curves for progression-free survival (A, C) and overall survival (B, D) in TKI alone and TKI+PD-1 group after stratification by peripheral blood lymphocyte count.
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PMC8956657
D Detailed hydrogen bonding mediating the MERS ORF4b Arg P0 at the Gly, Thr, Asp bonding pocket of IMPα2.
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PMC11544122
Parental and β-arr1/2 KO HEK293 cells transiently expressing FLAG-CXCR4, FLAG-β2AR, or FLAG-AT1AR were treated with vehicle or CXCL12 (50 nM), isoproterenol (10 µM), or angiotensin II (10 µM), respectively, for 30 min at 37 °C, and endocytosis was measured by ELISA.
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PMC9429973
Yiwu, Zhejiang, Peoples R China.
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PMC9429973
Results: By using CRISPR/Cas9 knockout we could validate ATP1B3 as a selective dependency and performing competitive growth assays we showed that loss of ATP1B3 in ATP1B1 low expressing AML cells leads to synthetic lethality.
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PMC10362265
Fig. 3Dynamics of the small surface helix in the human complexes.
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PMC5811757
Over the past decade, a revolutionary technology named genome editing has been developed that provides unique opportunities for researchers to manipulate genome in a wide range of cell types and organisms.
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PMC11402217
Osteosarcoma, the most prevalent malignant bone tumor, is notorious for its aggressive growth and invasiveness.
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PMC11001582
To determine differentially expressed genes, a linear regression model (two-sided) was used and P values were adjusted for multiple comparisons using the Benjamini–Hochberg FDR procedure.
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PMC11590870
It was measured every 2 min for 90 min at 37 °C using a microplate reader.
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PMC9509578
Their results demonstrated that the NPs are internalized via CD44 receptors present on the surface of ovarian cells.
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PMC11755519
In conclusion, regardless of gender, bladder cancer was the 10th most commonly diagnosed cancer worldwide in 2020.
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PMC11739670
T‐cell cultures were then screened for specificity in an IFNγ ELISPOT assay before FACS sorting for T‐cell clones based on either CD137 and CD25 expression following re‐activation by the relevant peptide or binding of the relevant fluorescently labeled pMHCI multimer.
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PMC11627060
In vitro cytotoxicity assay of isolated TQ and TQ-BSA Nps Cytotoxicity values are expressed as Mean ± SD (N = 3).
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PMC11806182
Our findings suggest these miRNAs could serve as potential biomarkers and therapeutic targets, offering insights into the molecular connection between PCOS and UCEC and aiding in personalized diagnosis and treatment strategies.
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PMC11607638
In vitro experiments confirmed the Gq‐coupling or calcium‐mobilizing property of the sulfakinin receptor.
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PMC11806182
This study has several limitations.
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PMC11746948
2GPX4 is palmitoylated at Cys 66.a Schematic of the workflow for identifying palmitoylated proteins using the click chemistry assay and LC-MS/MS.
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PMC11474209
While performing the analysis, sample preparation to concentrate the sample (MC-LR) is required.
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PMC11155445
FT-IR findings demonstrated that (172) chemically react with chalcopyrite surface through O and S of carbonyl and thiocarbonyl, forming a compound with chemical structures such as C–O–Cu and C–S–Cu (Fig. 97).
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PMC11291490
However, the ability of dusCD40L to assist DNA vaccine to promote neutralizing antibodies was unknown.
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PMC9429973
Of the 51 genes associated with ALL, 100% (103/103) gene mutation at the RNA level by WRTS is consistent with the results at the DNA level by targeted DNA sequencing (except 3 splice site mutations and 4 mutations with poor coverage).
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PMC8567602
In the third model, degradation targets SS18–SSX-containing CBAF.
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PMC7022782
Images were recorded by 5.0 Mpxl CCD digital camera (Nikon corp.,
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PMC11588085
To reprogram somatic cells into induced pluripotent SCs (iPSCs), loss of XIST is required during the inverse order of development and cell fate transitions (71).
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PMC11583010
Normal Human Epidermal Keratinocytes (NHEK; Lonza) were cultured in Keratinocyte Basal Medium (KBM) from Lonza supplemented with Singlequots products as recommended by the manufacturer.
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PMC9429973
The median OS was 7.8 years.
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PMC8270637
Immunotherapy for the HCC microenvironment has become an effective treatment strategy.
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PMC10142392
The work of Buwalda and colleagues , who synthesized PEG-PCL copolymers with an amide bond between the chains (PEG-NHCO-PCL), showed that PEG-NHCO-PCL hydrogels exhibited a higher storage modulus (13 Kpa) than conventional hydrogels that contain ester bonds between the PEG-OCO-PCL chains (1.6 Kpa).
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PMC9429973
②Compared with those without MF, MDS-MF were significantly associated with worse OS(P=0.035) and worse PFS(p<0.001).
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PMC9027909
Cultivated Caco-2 cells were incubated in 5% CO2 and 100% humidity at 37 °C.
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PMC11682224
Data are expressed as mean ± standard deviation; N = 3; **P < 0.01.
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PMC9429973
Constitutive erythropoiesis and repeated TP result in iron deficiency which further stimulates iron absorption and availability for robust erythropoiesis.
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PMC11593713
Glutathione reductase activity was determined using the kinetic method by Aebi .
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PMC9261184
Other sources of GHG emissions that were studied represented a low contribution to total GHG emissions of 3%, as shown in Figure 1.
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PMC11761919
More than 90% of target bacteria were completely released from the microcapsules within 15 min, and 100% was released within 1 h. The values represent mean ± SD, n=3.Fig 3 Characteristics of encapsulated E. faecalis in simulated gastricintestinal fluid. (
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PMC11730311
Peptides were fragmented with a normalized collision energy of 25%.
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PMC10969097
There were no specific time limits.
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PMC10772747
Among them, four compounds showed target gene relevance scores >7, namely Eleutheroside B, C, D, and resveratrol.
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PMC5673955
Levels of hTERT expression were normalized relative to the expression of reference gene 18S.
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PMC10958426
We clustered alternative ratio of SNVs in tumor subclones and identify many tumor subclones specific SNVs (Fig. 3F).
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PMC6450504
P-gp is overexpressed 33-fold on A2780-ADR cells compared to their sensitive counterpart (Figure 5(a)), and it is the main resistance mechanism against chemotherapeutics in this cell line.
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PMC10094992
In 2021, the publication of results from the phase III CheckMate 743 trial showed that the combination of nivolumab plus ipilimumab had a favourable clinical benefit–risk profile and gained approval from the regulatory agencies worldwide as a new option for patients with unresectable MPM.
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PMC11422150
We evaluated the motor sensory function by BMS and BBB scores, which have been widely used as locomotor estimating scales.
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PMC11682224
Further research on CHD1L will contribute to a deeper understanding of its specific mechanisms in cancer development, providing new targets and strategies for the diagnosis and treatment of cancer.
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PMC11583690
However, DTX's efficacy is hindered by poor target specificity and significant adverse effects.
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PMC9111184
The percentage of permeation (%) was calculated as the amount transported divided by the initial amount in the apical chamber.
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PMC7582629
As most pathologists and other clinicians are not spectroscopically well-trained, RS will be useful to them if there is a way to present the thousands of Raman signals, obtained from different cells, in an easily interpretable format, i.e., a Raman map.
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PMC5874706
Figure 3 displays the release profile of THN7 from loaded nanoparticles based on four α-CDs amphiphilic derivatives.
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PMC11352877
The endometrioid adenocarcinoma (A2780) cell line expressed a high level of TGF-β1 that led to a low ratio of VEGF-A to TGF-β1, which could be explained by the excessive decomposition of extracellular mass.
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PMC9429973
National registries are recognized as one of the main sources for real-world data that is utilized to enhance practice and conduct of medical research.
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PMC11401358
Cells without the addition of H2O2 served as the control group.
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PMC11747949
Collagenase 1 mg/mL and DNAse (Roche #52779120) 100 μl/2 mL added into 2 mL HBSS and incubated at 37°C for 15 min.
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