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BioData-CellLine_annotated

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PMC10093184
Immunohistochemical analyses revealed the mesenchymal origin of all COS cell lines as well as positive staining for the osteosarcoma-relevant proteins alkaline phosphatase and karyopherin α2.
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PMC11597291
All other chemicals and solvents were of analytical grade.
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PMC9429973
Despite therapeutic advances and slight increase in OS for patients diagnosed more recently, an unmet need for improved access to novel therapies remains, especially in those TCE patients.
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PMC10490530
A total of 25 μg of chromatin was precipitated with either anti-p53 or anti- NF-κB p65 antibody, and the DNA was eluted after reverse–cross-linking.
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PMC11320834
The development of PARPi/chemotherapy combinations requires preclinical solid data to support human clinical trial testing and extended in vitro studies to learn and understand the mechanisms of action.
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PMC9429973
Methods: In this study, we investigated whether GLS was involved in MDS progress.
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PMC11650848
Samples were quality controlled and normalised and a limma-based linear model was used.
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PMC11680982
Two groups received the control vehicle and fulvestrant (ICI182780, 100 mg/kg in the vehicle, administered once weekly by subcutaneous injection, obtained from AstraZeneca), in combination with palbociclib (PD0332991, 150 mg/kg in the vehicle, administered five days per week orally, from Pfizer).
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PMC11720808
TLR4 overexpression also attenuated the decrease in the viability of 143B cells induced by SCU treatment (Figure 5C).
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PMC9848491
The expression levels and lncRNA-mRNA network of eight endoplasmic reticulum stress -related lncRNAs in the predictive signature. (
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PMC2196094
RMCP-1 is the most abundant serine protease expressed by rat CTMCs whereas RMCP-2 is the major mucosal MC protease (5).
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PMC10899471
Specific primer sets were provided in Supplementary Table S1 .
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PMC10547921
Nilchan et al. used a dual antibody conjugating method to generate a dual-payload ADC containing the targeted tubulin payload MMAF and DNA topoisomerase II inhibitor PNU-159682 by specific conjugation of HER2 antibodies at the engineering selenized cysteine and cysteine residue sites.
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PMC10729469
This was found through the deployment of regulatory T cells (Tregs).
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PMC11655498
BPLF1 modulates the DNA damage response induced by EBV lytic replication, collaborating with RAD18 to enhance the production of infectious viruses (Kumar et al., 2014).
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PMC9693627
In Blue-Native Western blots PTCD2 was not detected in association with any complexes.
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PMC11629192
The CSF anti-NMDAR antibody became negative.
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PMC10907726
p < 0.05 (with DATS). **
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PMC11412721
mRNA levels of the indicated genes were quantified in MEFs of the indicated genotypes left untreated or treated for 24 hr with 15 μM etoposide (Eto).
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PMC11637284
Schematic representations of TAC60ΔC283-myc and mini-p166-HA compared to the corresponding full length proteins.
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PMC11095939
Briefly, 293T cells were co-transfected with various plasmids.
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PMC11674891
Previous studies have demonstrated that overexpression of CRABP2 and FNDC4 can enhance cell invasion and metastasis in various cancers .
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PMC9429973
Odds ratio, transformed into a response-rate ratio (RR) (along with 95% confidence interval [CI]), derived from weighted logistic regression was used for binary endpoints (ORR, VGPR rate, and ≥CR rate).
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PMC11750712
The Live/Lysis solution was added to the blood and incubated.
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PMC9429973
Methods: We generated an immortalized AML cell line by serial transplantation of fetal liver cells carrying biallelic CEBPA mutations (CNC, Cebpa N-terminal/C-terminal) followed by prolonged culture of leukemic cells.
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PMC11412721
GSEA, performed in Trp53 Eμ-Myc (WT_Myc) and Trp53 Eμ-Myc (p53DAS_Myc) male splenic cells, indicated an enrichment of hallmark Myc targets in Trp53 Eμ-Myc cells.
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PMC10808409
After incubation for 24 h, the cells were treated with IC50 of FA and O2 for 48 h, and rinsed 3 times with ice-cold Phosphate buffer saline.
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PMC11721277
In addition, salivary gland accumulation was slightly but significantly (p < 0.05) lower at the 1.2 mg/kg dose compared to the 12 mg/kg dose, 0.9 ± 0.1%ID/g and 1.3 ± 0.1%ID/g, respectively.
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PMC10898159
MiR-148b-3p was largely described in the constraints of neoplastic transformation .
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PMC11739484
P-value < 0.05.
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PMC6617630
a Cells (0.5 × 10) from wild-type MYC (U2932), double-hit (DOHH2), and triple-hit (Val) B cell lines were harvested, and PD-L1 expression was determined by flow cytometry.
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PMC11201989
We found that depletion of PD-L1 increased the population of cilia positive for Rab8a (Figure 3C,D) and BBS5 (Figure 3E,F) in NIH3T3 cells.
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PMC11126803
In our study, we found that ZEB1 could reverse ERβ-enhanced ccRCC VM formation and invasion.
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PMC2944824
All procedures were approved by the Animal Use Committee of Johns Hopkins University and adequate measures were taken to minimize pain or discomfort to the mice.
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PMC11335267
In addition, the existence of reduced muscle innervation is supported by decreased levels of Syb-2, a presynaptic vesicle marker.
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PMC10729469
Similarly, RPLP0 gene was used as the reference gene.
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PMC9429973
Results: The percentage of multiple lymphocytic subsets and number of plasmacytoid dendritic cells (PDCs) were significantly significantly lower in the samples from MDS patients compared to the samples from non-malignant controls.
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PMC9429973
Aims: The aim of the study is to clarify the value of combining the glitazones with the TKIs in the treatment of denovo CML CP patients as regard the patients’ response and effect of this combination therapy on the expression of CITED2 gene.
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PMC10809689
Fig. 1TIM-3/Gal-9 and glutamine metabolism.
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PMC10530622
For instance, nutritional intervention for microbiota correction in the context of lithiasis has not been fully explored, since these approaches remain much focused on oxalate metabolism and intake.
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PMC11670954
Y-27632 collaborated with BA to alleviate the decrease in FD-4 flux in LPS-induced Caco2 cells on day 22.
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PMC9429973
Thus, it can be used as a fast alternative to conventional analyses.
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PMC11697703
Other important processes relevant to cortical development and regulated by either miR-193b or miR-365 include cell migration, regulation of cell morphogenesis, neurogenesis, and learning and memory.
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PMC9429973
On the other hand, to unravel the consequences of losing PSIP1 expression during tumor maintenance a proliferation competition assay was performed and RNA-seq profiling was used to identify downstream targets of PSIP1.
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PMC11724582
No. KGEHC107b-1; KeyGEN Biotech Co., Ltd.) was used to quantify the TGF-β1 levels according to the manufacturer’s guidelines.
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PMC11371747
[H]-l-LV influx was terminated by adding 9 mL ice-cold HBSS, centrifugation and an additional wash of the cells with 10 mL ice-cold buffer.
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PMC11597291
Graphene Oxide (GO) family nanomaterials, including GO, reduced GO (rGO), and carboxylated GO (CGO), have gained increased attention for biomedical applications, especially in the fields of drug delivery and theranostics .
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PMC11701801
All IHC staining was performed using a Dako autostainer Link48 (Agilent Technologies).
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PMC11285179
In the cellular communication network, pericytes interact closely with various cell types.
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PMC10589262
Bafilomycin A1 (BafA1), a lysosomal inhibitor, was used to validate lysosome-mediated protein degradation.
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PMC9429973
Median survival was 24 months.
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PMC11612794
GFP-Dsn1 or GFP-Dsn1, in which Aurora B phosphorylation sites are substituted with alanine (4A: S97A, S101A, S102A, and S111A), was expressed in AID-based CENP-T conditional knockdown CENP-C/CENP-T cells or CENP-C/CENP-T cells.
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PMC9368503
We further sought to better understand the biological differences between ICR-SS-1 and the two commercially available synovial sarcoma cell lines SYO-1 and HS-SY-11 by performing a t-test to identify the proteins that are significantly different between these two groups.
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PMC11656657
The 143B OS tumor did not affect the memory profile of control NT T-cells (Fig. 3M), while the naïve compartment of CAR.GD2 T-cells (Fig. 3N), after 5 days of co-culture, rapidly decreased from 64.8% ± 11.7% to 5.2% ± 2.5% (p = 0.03), with a significant enrichment of both TCM (from 19.1% ± 4.2% to 54.6% ± 30.3%, p = 0.036) and TEM compartment (from 8.6% ± 4.8% to 32.9% ± 24.9%, p = 0.015).
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PMC11541409
Double mutation in exon 11 (deletion) and exon 17 (activation loop) create a TKD conformation which could have enhanced catalytic velocity and affinity to ATP .
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PMC10391797
Immunotherapy offers promising opportunities with the potential to induce sustained remissions in tumor patients.
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PMC11222184
Vrenken et al. revealed that loss of SNAI2 function in neuroblastoma cells strongly sensitizes these cells to retinoic acid therapy while reducing self-renewal, invasion, and metastatic spread in vivo .
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PMC11591030
In the AOP + ML385 group, ML385 inhibited the effects challenged by AOP, and the addition of ML385 alone did not result in significant changes in any of the parameters compared to the control group, suggesting that ML385 itself does not affect the cells.
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PMC9429973
4 pts were also treated with corticoids without any response.
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PMC9096373
The methods and steps of CD31, Ki-67, and γ-H2AX were similar to those used for the determination of VEGFR-2, with the exception of the primary antibodies targeting CD31, Ki-67, and γ-H2AX (Bio‑World, USA), respectively.
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PMC11271800
TAMs in untreated mouse models and imatinib-resistant GIST are functionally more similar to M1 TAMs, whereas TAMs in sensitive GIST are functionally more similar to M2 TAMs.
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PMC9429973
Both after-switch treatments were well tolerated and adverse events were all grade 1–2 in severity.
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PMC9429973
In addition, a significant fraction of patients unable to mount an antibody response fail to clear SARS-Cov2 virus putting them at risk for clinical deterioration.
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PMC9429973
Fifteen pts discontinued ASC due to treatment failure (n=11), progression of disease to blast phase (n=3) or grade 4 thrombocytopenia (n=1).
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PMC11543885
Match Between Runs (MBR): Enable the Match Between Runs (MBR) function to align features across different runs.
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PMC11575040
Therefore, understanding the primary mechanisms of metformin may aid in the development of novel treatments.
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PMC11779876
Single-cell TCR sequencing was performed using the Next GEM Single Cell 5’ Kit v2 and Chromium Single Cell Human TCR Amplification kits (10X Genomics, Pleasanton, CA, USA).
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PMC9429973
Aims: We aimed to investigate trends in overall survival (OS) and other HCT-related outcomes in a population-based cohort study of all adults (≥18 years) who received a first HCT for AML in Denmark between 2000–2020.
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PMC10812665
High levels of phenolic metabolites in urine are a hallmark of tyrosinemia type III, a rare inherited disorder associated with neurological symptoms .
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PMC10213199
As a result, 12 933 genetic targets and 28 212 diseases were identified as associated with 7263 TC M and 49 258 chemical components.
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PMC11015054
Reverse: 5'-CACCTTCTACAATGAGCT GCGTGTG-3'.
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PMC8623816
The segment encoding the RNA-dependent RNA polymerase (RdRp) protein is named dsRNA-1, and that encoding the coat protein (CP) is designated as dsRNA-2 .
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PMC9429973
The median platelet count at diagnosis was 30 ×10 cell/uL, while the lowest was 9 ×10 cell/uL. The initial recorded diagnosis was ITP in 65% of patients, followed by Glanzmann thrombasthenia (7.5%), CAMT and WAS (5% each).
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PMC4270159
0.001 µM–10 µM PLX4032 + no ligand.
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PMC11564405
B The infiltration density of CD8 + T cells in the low RILPL2 expression group and high RILPL2 expression groupTable 2The correlation between RILPL2 expression and CD4 + T cell infiltration in 140 patients with primary NSCLCNSCLC samplesCD4Correlation coefficientP valueLowHighRILPL2 low58390.294P < 0.001RILPL2 high1231Data were analyzed using the chi-square testTable 3The correlation between RILPL2 expression and CD4 + T cell infiltration in 66 patients with LUADLUAD samplesCD4Correlation coefficientP valueLowHighRILPL2 low31150.2560.038RILPL2 high812Data were analyzed using the chi-square testTable 4The correlation between RILPL2 expression and CD4 + T cell infiltration in 74 patients with LUSCLUSC samplesCD4Correlation coefficientP valueLowHighRILPL2 low27240.3330.004RILPL2 high419Data were analyzed using the chi-square testTable 5The correlation between RILPL2 expression and CD8 + T cell infiltration in 140 patients with primary NSCLCNSCLC samplesCD8Correlation coefficientP valueLowHighRILPL2 low57400.2630.002RILPL2 high1330Data were analyzed using the chi-square test Relationships between RILPL2 expression and CD4 + T cell infiltration in 140 patients with primary NSCLC.
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PMC11190062
The membranes were blocked with 5% bovine serum albumin in 0.1% Tris-buffered saline with 0.01% Tween (TBS-T) or 5% dry milk in TBS-T, followed by incubation with primary antibodies for 1–3 days.
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PMC11577421
Next, NPs were added to the culture medium, and uptake experiments were conducted for 2h; (ii) Cells were incubated with heparin or totally N,O-desulfated heparin (100 μg mL) for 2 h, followed by treatment with NPs for an additional 2h. (
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PMC8009078
The drug-likeness and pharmacokinetic parameters of the final five molecules are given in Table 2.
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PMC9429973
Summary/Conclusion: In conclusion, the BNT162b2 anti-SARS-Cov-2 mRNA vaccine demonstrated efficacy in our cohort of TDT and SCD patients.
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PMC11344246
After incubating at 37°C in 5% CO2 for 20 min to allow solidification of Matrigel, 35 μl of organoid growth media was added to each well using the Biotek EL406 Liquid Handler.
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PMC11473843
Relative cell number of HBEC3-FAK KO cell line transduced either with wild-type FAK (pWZL Hygro-FAK WT) or FAK (pWZL-Hygro-FAK) in the absence or presence of mutant KRAS (pBABE-zeo or pBABE-zeo-KRAS ).
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PMC9429973
The most common symptoms at presentation were fever, cough, muscle pain, headache, fatigue.
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PMC11495567
Cotton swabs were used to wipe the inserts to remove non-invaded cells.
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PMC10578720
Histograms show statistical analysis of the degree of colocalization between SIRT3 and CS/PDHC based on Pearson correlation coefficients (mean ± SD).
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PMC10291556
As indicated, the platinum(II) precursor 1 demonstrated potent activity with submicromolar IC50 values, in agreement with the already published data.
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PMC11531744
The cells of GBP1P1 knockdown were identified by quantitative real-time polymerase chain reaction (qRT-PCR), and fluorescence imaging using fluorescence microscopy (Lecia, Wetzlar, Germany).
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PMC11489275
Low baseline lymphocytes and gradually declined lymphocytes are both associated with a high risk of death within 1 month.
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PMC8097906
The metabolite profiling of 48 h VSM (25 μg/ml) as well as cisplatin (3.3 μM) treated RH-30 cells was conducted by gas chromatography–mass spectrometry (GC–MS) as described previously .
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PMC11653533
For instance, its bark, fruits, leaves, roots, latex, and seeds have been used therapeutically for many years, sometimes in conjunction with other spices, particularly to treat a variety of illnesses including diabetes, liver problems, loose bowels, inflammatory diseases, hemorrhoids, respiratory and urinary problems (Deep et al., 2013).
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PMC10538569
Interestingly, co-culture of the iDCs with captured R5-tropic HIV-1 AD8 and CEMss-CCR5-GPI-scFv X5 resulted in decreasing virus production compared to iDCs with HIV-1 AD8 alone, which increased over time.
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PMC10443665
ABC transporters' superfamily comprises more than 40 different proteins such as permeability glycoprotein (P-gp), multidrug resistance-associated proteins (MRP), breast cancer resistance protein (BCRP), etc. (
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PMC9429973
Summary/Conclusion: In literature there are few publications that highlight the coexistence of MGUS in MPN patients.
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PMC3734024
In this case, it is likely that different growth factors would differentially act on B cells from these different lineages.
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PMC11703992
CCR7 expressed high activity in majority of DDIT4+ CD4+ Memory T cells, promoting the circulation of Memory T cells in blood.
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PMC11694066
Prior to the 384-well plate screen, solid small molecules were resuspended in DMSO as 10 mmol/L stocks, prior to further dilution in DMSO to create 384-well plates containing a titration (0.5, 1, 5, 10, 50, 100, 500, and 1,000 nmol/L).
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PMC11047729
In PBMC and CD34+ stem cells, firstly, low telomerase levels increased and in HL-60 initially, high telomerase activity decreased.
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PMC11757131
The SPSS statistical software program (v. 19.0, SPSS; IBM SPSS Company, Chicago, IL, United States) was used to test the significance of the data using one-way analysis of variance, and Tukey’s test was used to determine the differences among the groups.
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PMC6600253
Additional studies have demonstrated that treatment with these compounds can shorten the 3′ overhang and result in a DNA damage response in tumor cells .
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PMC11585565
CNNM4 mRNA and protein was analyzed as previously described.
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PMC8097906
The metabolic profiles of treated RH-30 cells show a similar responding in three metabolites to the VSM and cisplatin treatment.
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