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PMC11672142
Multiwell plate absorbance was measured in an Infinite M200 PRO Tecan Microplate Reader.
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PMC9429973
Pts in DRIVE-PK and ACTIVATE were not regularly transfused (≤3 RBC units and ≤4 transfusion episodes in the prior yr).
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PMC11413393
Cells were then blocked in 5% non-fat dried milk in PBS for 1 h at RT.
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PMC11348300
While the results in this paper primarily address full-size tumors (~8 mm diameter), initial measurements were conducted on tumors reaching half maturity (approximately 4 mm in diameter).
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PMC11680982
A,B) After knockdown of HER2, the effect of the triple combination of neratinib, CDK4/6 inhibitor, and endocrine therapy on HR/HER2-low breast cancer cell proliferation was assessed by the CCK-8 and colony formation assays. (
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PMC11791478
The internalization of fluorescently labeled XB002 and 25A3 was tracked over time in A431 cells.
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PMC11335267
Box-and-whisker plots show median values, first and third quartiles, as well as maximum and minimum values. ***
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PMC9429973
Results: In total, 34 (100%) participating laboratories reported the use of either amplicon or capture based NGS methods, with assay LOD ranging from 1-15%, with a median LOD of 5%.
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PMC6102174
The rhizomes of C. rotundus (Xiangfu) recorded in every edition of Chinese Pharmacopoeia have been widely used as a traditional Chinese medicine to cure liver diseases, pain and women’s diseases.
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PMC9429973
The median follow-up and DOR were 290 days.
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PMC2777936
Protein lysates from treated cells were analysed using the activated β-catenin (ABC) antibody, which specifically recognizes the nonphosphorylated form of β-catenin .
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PMC11612626
More than 1,500 peptides were increased two-fold after treatment of cells with compound A. E, Waterfall plot representing peptides upregulated by compound A and downregulated by bortezomib treatment of RPMI-8226 cells.
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PMC11194678
On the other hand, STAU1 recruitment to the 3′UTR of target mRNA elicits the SMD pathway to promote RNA degradation (Gong and Maquat, 2011; Kim et al., 2005) or prevents its translation (de Morrée et al., 2017; Elbarbary et al., 2013).
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PMC11545737
In addition, HrpA binds to the motor protein dynein, enabling the bacterium to move along the microtubules.
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PMC8557138
Ghosh et al. 2007).Role of tumor organoid models in understanding angiogenesis mechanismsOrganoid models, which are in vitro 3D tissue constructs derived from either stem cells or iPSCs mimicking the in vivo environment of the corresponding organ holds promising implications in studying human development and diseases.
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PMC7723249
We have shown that CCHFV and HAZV early in infection use different strategies for entry.
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PMC10940855
Sections (10 μm) were taken using a Leica CM3050 S. All slides were rehydrated with PBS, permeabilized with 0.30% Triton X-100 in PBS, and treated with a blocking solution (5% BSA, 5% goat serum in PBST).
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PMC9429973
Patients treated with pacritinib vs ruxolitinib achieved higher rates of SVR (22% vs 3%, p=0.02) and numerically higher rates of mTSS response (35% vs 19%; p=0.11) at week 24 (Figure 1A).
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PMC9429973
In Egypt which has a population of approximately(80 million) consanguineous marriage are frequent, there fore recessive coagulation disorders reach a higherprevalence than in many other countries.
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PMC11352746
Additional software components can be added for specific applications that range from chemotaxis migration quantification to the quantification of neurite outgrowth, to name a few.
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PMC11615828
The experiment utilized the “bleaching,” “time series,” and “regions” functions of ZEN software.
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PMC11798926
In experiments comparing three or more groups, if the variance was not significantly different, we used a one-way ANOVA with post-hoc Tukey test.
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PMC10723784
The fluorescence was measured by the FLOUstar OPTIMA plate reader with the excitation at 354 nm and emission at 442 nm.
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PMC9611901
The tanning agents used in the tanning process react chemically with the collagen molecule that makes up the natural skin and stabilise the triple helix structure of the collagen nucleus, making the leather resistant to chemical, thermal and microbiological degradation.
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PMC11507371
Argon gas (ALPAHGAZ 1, 99,999% purity, AIR LIQUIDE Deutschland GmbH, Germany) served as a feed gas with a flow of 1.9 slm .
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PMC10748106
Additionally, a single-point calculation using the B3LYP functional and 6-311 + G** basis set in vacuum (in water for 10-O-(E)-p-coumaroylgeniposidic acid) was performed.
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PMC11694625
Besides hydrogen bonding, there were also hydrophobic forces existing with some amino acid residues, such as Lys-133, Phe-80, Leu-83 and Leu-135 of CDK1, and Val-35, Ala-50, Ala-155 and Arg-356 of CDK8.
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PMC6889484
For generating A33G(DK) or A3x3G(DK) virus, pVif2-HA (2–4 μg) was also included in the transfection to degrade any expressed A3G-D128K in the producer cells as a result of direct repeat deletion during transfection.
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PMC10831439
Apart from exhaustion markers, functional assays are more adequate to better describe this phenomenon.
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PMC11531744
At the bottom of QC, the cell populations were tagged based on marker genes.
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PMC9429973
8(30%) pts with DS needed ICU admission.
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PMC11707577
p<0.001, p<0.0001.
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PMC9221284
In addition, the 5′UTRs of three transcripts (Trans1,2,3) contains termination codons in all three reading frames whereas the two 5′UTR transcripts (Trans4,5) (Figure S5) are in reading frames of a part of exon 2 and the coding region of c-MycS. The genomic region corresponding to transcripts 1 and 2 (Trans1 and Trans2) resulting from P1 promoter use (Figure 3 and Figure S4) revealed that the mature Trans1 mRNA (Figure 3 and Figure S4) is derived from the canonical splicing of a c-MYC pre-mRNA (Figure 3B and Figure S4) that was previously described .
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PMC11521786
The latest could enhance the endocytosis and degradation of the targets, resulting in a consequent superior impact on tumor cells compared to MAbs, whether used alone or in combination (25, 26, 37).
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PMC11721277
These compounds bind to and accumulate in tumor cells through various mechanisms, such as the “enhanced permeability and retention (EPR) effect”, binding to low-density lipoproteins , capture by macrophages, and increased solubility at low pH .
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PMC11453018
Mice treated with iP300w exhibited significant reductions in both tumor size and mass compared to control groups.
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PMC11705067
All procedures involving human participants in this study complied with the Declaration of Helsinki (2013 revision).
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PMC9412887
As shown in Figure 7h,i, the antitumor effect of T12/P-Lipo was better than that of other groups, indicating the prospect of dual-targeting drug delivery in improving the treatment of BMs and surmounting the cancer resistance of EGFR mutation.
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PMC9509578
Curcumin was found to efficiently inhibit the P-gp drug efflux transporter, resulting in elevated intracellular paclitaxel retention, inhibition of cellular migration and cytotoxicity and enhanced reduction in tumor growth in a murine model .
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PMC10114490
Second, we always produced in parallel a control lentiviral vector expressing GFP (pHIV-eGFP-FOXA3) and infect human fibroblasts.
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PMC7136814
MYOG is one of the myogenic regulatory factors that is downstream of MEF2, MYF5, MRF4, and MYOD1 that drive skeletal muscle cell differentiation .
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PMC11740508
Means ± SEM shown, significant difference from Tala alone treatment determined by two-way ANOVA with Tukey’s adjustment for multiple testing.
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PMC9429973
To summarize,BPD is an safe,effective, and economical treatment, and there are no studies of BPD in the regimen of RRMM with EMD,so it is worth exploring in domestic clinical trials.
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PMC8592717
It also suppressed breast cancer cell growth and promoted apoptosis of these cells by downregulating b-catenin- and cyclin D1-mediated multiple signal pathways .
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PMC9429973
Prevalence of hypertension, coronary artery disease (CAD) and myocardial infarction were similar between the groups.
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PMC3681794
24 hours after transfection cells were sorted on the BD FACSVantage™ SE Cell Sorter (BD Biosciences) and cells positive for GFP retained.
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PMC11352666
Outcomes are poor in patients with metastatic or relapsed disease, and new treatments are urgently needed.
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PMC8143558
For example, the results presented in Table 1 show the differences in saponin content in aqueous extracts of various parts of Eucalyptus camaldulensis Dehnh as follows: roots (341 mg/g), bark (199 mg/g), fruits (171 mg/g), and leaves (97 mg/g).
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PMC11180402
SOX2, a transcription factor, recognized as a stem cell marker, exhibits increased expression in BC across both mouse models and human tissues .
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PMC11628904
In control larvae, but not those treated with isotonic medium, C. albicans appeared to overlap with viable tissue corresponding to zone 2.
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PMC11742864
Tumor inflammatory microenvironment is important for tumor survival, and inflammation acts as a cancer trigger to facilitate cancer invasion.
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PMC9599726
Cell viability was estimated using a WST-1 assay (Roche, Indianapolis, IN, USA, Cat# 5015944001).
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PMC8041314
The focus of this work was to discover new heteroaromatic scaffolds as multitarget ABCB1, ABCC1, and ABCG2 inhibitors.
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PMC9388315
In addition, various studies revealed that HSF1 is associated with metastasis, cancer cell survival, and tumor proliferation.
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PMC9268183
Cancer is one of the leading causes of death worldwide, accounting for nearly 10 million deaths in 2020 .
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PMC10914904
All the available knowledge regarding the effect of vtRNAs on innate immunity is based on the use of raw molecules.
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PMC11451829
To further our understanding of this challenging ocular condition, it is essential to establish a reliable animal model that can mimic the inflammatory environment for the development of pterygium-like lesion to evaluate new pharmacological or surgical treatments.
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PMC9429973
The remain cases were non evaluable (15/40).
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PMC8526701
To investigate the functional role of BRD9 in GISTs, we validated the expression of BRD9 in clinically confirmed GIST specimens, which included 38 GIST tissues that were compared with 25 adjacent nontumor tissues.
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PMC11754094
The fragmented samples were purified using the Expin PCR SV kit (GeneAll) and prepared as an NGS library with NEBNext Ultra II DNA Library Prep kit for Illumina (NEB).
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PMC9429973
274 patients were treated with HSCT as most intensive therapy (28%), 348 patients with induction and consolidation (35.6%).
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PMC11225860
In many tumor types, inhibitors of AK-A and/or AK-B lead to polyploidy, latter due to cytokinesis failure .
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PMC10055960
It suggested a negligible displacement of the pyridyl moieties in the presence of DMSO.
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PMC11786767
Cells were treated with 50 nM nocodazole for 6 h to synchronize the cell cycle at prometaphase.
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PMC8623816
To identify genes of Rhizoctonia solani AG-1 IA that play key roles in response to RsRV5 infection, RNA-seq technology was applied to compare the expression of fungal host genes in isogenic strains D122 and D122-P. Data analysis showed that for samples of strains D122 and D122-P, there were a total of 33 million and 31 million reads, respectively, of which an average of 73.88% and 76.17% reads, respectively, were aligned to the Rhizoctonia solani AG-1 IA.
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PMC11787355
Single-cell sequencing of primary brain tumors shows PTPRZ1 overexpression in malignant cells, especially in glioblastoma stem cells (GSCs) and astrocyte-like cells.
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PMC7553912
Data are expressed as mean ± SEM; n = 4–5 per group. *
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PMC9919300
These tricarboxylic acids cycle generates NADH and FADH2 which are transported to the electron transport chain and further oxidized into NAD and FAD with the generation of H2O.
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PMC9429973
Newer therapies, including T cell engagers (TCE) and chimeric antigen receptor (CAR) T cells that target specific molecules overexpressed on leukemic blasts and stem cells are promising alternative treatment options for AML.
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PMC10965315
NIH/3T3 cells is a widely used embryonic fibroblast cell line in early‐stage drug discovery to test the efficacy and safety of potential drugs (Rahimi et al., 2022).
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PMC11740207
CD133 PSCs have been identified in various human adult tissues, including peripheral blood, bone marrow, the brain, and even in cancerous tissues (Shmelkov et al., 2008; Wu and Wu, 2009; Kreso and Dick, 2014; Shaikh et al., 2015; Glumac and LeBeau, 2018; Wang et al., 2020; Korn et al., 2021; Nayak et al., 2022; Liu et al., 2023).
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PMC9429973
We defined an alternative high-risk group by including the 143 patients with the lowest predicted 5-year OS based on the stacking-model.
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PMC11684269
Loss-of-function study found that in the context of DKD, ABCA1 deficiency in glomerular endothelial cells worsens cellular cholesterol accumulation and glomerular endothelium injury (100).
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PMC11228511
Scale bar, 5 µm.)
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PMC9429973
Therapeutic response analysis showed that the majority of patients (88%) had at least a partial response.
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PMC7823217
Before the development of 3D HSEs, Hill and colleagues developed a representative skin model based on the human fibroblasts laden within an inert porous scaffold where the myeloma cells move radially and vertically during tumor progression .
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PMC9429973
Leukemia burden of CLL mice was quantified by luciferase intensity using bioluminescence imaging.
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PMC11723210
Biological cells are often colorless and transparent, resulting in low contrast under brightfield illumination.
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PMC10040136
All statistical analyses were performed using GraphPad Prism (GraphPad Software, Inc., San Diego, Calif.).
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PMC9429973
Functionally, IL21 inhibited cell growth and clonogenic potential of primary AML stem and progenitor cells but not normal hematopietic stem cells (HSCs).
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PMC11502327
Different drug doses and components may have differentiated anticancer and protective effects on the female reproductive system, so more effective pharmacodynamic evaluation methods are urgently needed to evaluate the effectiveness of NNDDS in clinical application.
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PMC10523483
Nuclear factor-erythroid 2-related factor 2 (NRF2) is a transcriptional activator that acts as the master regulator in cellular antioxidant defense (6).
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PMC11546117
Three analytical methods were used for different groups of probe substrates: (1) atenolol, propranolol, and fexofenadine, (2) sulfasalazine and CDF, and (3) metformin and methotrexate.
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PMC11463018
To further compare the sensitivity discrepancy of various cell lines to triazolopyridines, the mean log GI50 values of 19 for cell lines from the same type of cancer was calculated.
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PMC9503669
NMR studies showed interaction of 2C with the Nef SH3 binding site and more strongly with a cleft between the β-sheet and the C-terminal α-helices of the folded Nef core.
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PMC11342785
B, representative images from NIH3T3 cells (FusionRed, white color in images) showing the size and distribution of the IDR-droplet component of the different synMAP circuits.
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PMC7342409
In the future, large sample studies are needed to confirm.
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PMC11357960
Responders were defined as a patient who achieved complete response (CR), partial response (PR) or stable disease (SD) after anti-PD-1 immunotherapy for more than 24 weeks.
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PMC11802855
T The mean growth rate of subcutaneous xenograft tumors in CXCL7-OE and NC mice.
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PMC6650823
Highlighted by Stefania Galdiero Brain cancer is a major public health problem worldwide and a leading cause of death.
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PMC6461034
The EGFR INKA score was significantly higher and dominating in U87‐EGFRvIII relative to wild‐type U87 (Fig 5A).
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PMC11544122
For all graphs, data are presented as a mean ± S.E.M. or ±S.D. with individual data points from the indicated replicates as specified within the figure legends.
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PMC11391695
pcDNA/PEI/NPs@M inhibited the proliferation and metastasis of HCC cells in orthotopic HCC transplantation model.
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PMC10093184
In D-17 spheroids, central, intermediate and outer zones (necrotic, quiescent, and proliferative) were clearly defined as previously described .
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PMC10565698
The lack of early diagnosis has led to unsatisfactory treatment of LC.
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PMC11190238
Some of the transcription factors and regulators known to regulate the different phases of the epithelial-to-mesenchymal transition are shown below the spectrum (epithelial regulators – purple, and mesenchymal regulators, orange).
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PMC8584666
To verify GPI-80 secretion in EVs, soluble GPI-80 (sGPI-80) was measured in the plasma of prostate cancer patients and in the conditioned medium of PC3 cells expressing GPI-80 using sandwich ELISA with two types of anti-GPI-80 mAb clone, 3H9 (IgG1, used for capture) and 4D4 (IgG2a, used for detection).
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PMC5363531
In REN and MPP89 cell lines, dasatinib shifted the cytostatic activity of PEM to cytotoxic/anti-proliferative effect.
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PMC11621493
The disposition of lipoprotein-derived MAG is poorly investigated.
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PMC7504302
Further, AZD4547 treatment resulted in a significant growth inhibition in the FGFRi-sensitive MPM lines that were reconstituted from tumors, confirming the therapeutic potential of the FGFR pathway in a subset of MPM patients.
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