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OTAR3088
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BioData-CellLine_annotated

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PMC10926885
In 5A media, the T24 cell line was grown.
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PMC9792775
The PTX standard peak was 60.0 g/ml of PTX.
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PMC6889484
Voit et al. inserted A3G-D128K along with a dominant-negative mutant of HIV-1 Rev (RevM10) and human/rhesus TRIM5α by gene editing into the CCR5 locus.
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PMC11001582
NS denotes P > 0.05.
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PMC11588008
Independent-samples t-test was used to analysis of differences between two groups with a statistical significance set at p < 0.05.
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PMC11790971
The t-distributed Stochastic Neighbor Embedding (t-SNE) plots in Fig. 3a–c depict the distributions of cells from each cell line in passage 0, passage 1, and passage 2, respectively.
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PMC11750712
Samples were rested overnight in TexMACS10 medium (Miltenyi Biotec) after thawing.
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PMC9848491
IC50 of DMOG in high and low risk groups. (
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PMC10551595
To the best of our knowledge, this is the first time that GinA has shown anti‐leukemic behavior.
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PMC11055510
The SKOV3, A2780, and IOSE-80 cells were cultured in Roswell Park Memorial Institute-1640 (Gibco; Thermo Fisher Scientific, Inc., Waltham, MA, USA), and HEK 293 cell lines were cultured in dulbecco’s modified eagle medium (Gibco) at 37 °C with 5 % CO2.
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PMC11704834
In addition to induction and/or activation of the intrinsic mitochondrial pro-apoptotic Bcl-2 family members such as BIM, downregulation of anti-apoptosis effectors (for example, survivin) has been shown to promote gefitinib sensitivity (5,6).
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PMC11300639
The cells were washed twice with PBS and fixed with paraformaldehyde for 20 min, and then stained with crystal violet for 30 min.
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PMC10317042
Data in A and D–F are means ± SDs. *,
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PMC11319300
In the context of cancer, the insertion of super-enhancer elements from different chromosomes into the intergenic region flanked by the MYEOV-3′-putative enhancer and CCND1 culminates in the emergence of an expansive active regulatory domain spanning the CCND1 gene locus.
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PMC7185206
TAPI-2 treated cells showed increased total PD-L1 and starting surface PD-L1 (white arrows).
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PMC9118379
To determine the similarity score threshold for a variant-predicted spectral pair to be similar (i.e., a reliable variant spectrum supported by the predicted spectrum), we adopted a target–decoy strategy in which similarity scores were calculated between all pairs of a variant spectrum and a predicted spectrum (workflow illustrated in Figure S4).
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PMC11087055
Here, we have described the distinctive set of cell flows that precede gastrulation in the chick embryo, and the relationship between early and late cell flow has yet to be examined.
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PMC9429973
Environmental factors including air and other sources of pollution and weather are potentially modifiable factors that are associated with disease severity in children and adults with SCD in ecological studies of exposure.
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PMC11786767
An LSM700 microscope was used to acquire images of the cells in prometaphase.
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PMC10506676
Based on the study by Ferber et al., it was found that in CC, the HPV-18 genome is integrated in a region near the c-MYC gene and can cause the activation of this proto-oncogene (39).
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PMC11412721
Means ± SEM (n = 6). (
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PMC11055323
The experiments were not randomized.
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PMC10729469
Scale bar = 50 µm.
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PMC11674834
This is consistent with a previous study reporting that 3,4-DMA induced DNA damage in chicken egg liver measured using comet assay .
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PMC7039683
Concordance for non-syndromic cleft lip with or without cleft palate (NSCLP) is about 50% in monozygotic twins, suggesting a strong genetic contribution to the etiology of OFC (Little and Bryan, 1986; Takahashi et al., 2018).
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PMC6901583
The colony formation assay showed higher numbers and sizes of colonies in the cells, expressing BRD4 than those in control vector-transfected cells (Fig. 2d).
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PMC9429973
Results: A total of 188 children were included, with 164 (87.2%) SS children.
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PMC6268318
This genus presents itself as a promising new scientific research topic to investigate the pharmacological potential of the extracts, fractions and compounds isolated from plant species of this genus.
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PMC11040965
Staining with an anti-DNMT3B antibody (Abcam ab2851; 1:250 dilution) was done using an automated stainer (BenchMark Ultra, Ventana-Roche Diagnostics).
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PMC9429973
Seroprevalence of hepatitis Bi, hepatitis Ci, humani immunodeficiencyi viruses iand isyphilis were determined in 10.300 wholei blood donationsi collected ini the centre region Algeriani Results: The prevalence of serological markers HIV, HBS, HCV and syphilis is respectively 0%, 24%, 0.67 and 23%.
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PMC8526701
However, GSK602 treatment did not affect the expression of other pro-apoptotic Bcl-2 family members, including but not limited to Bim, Bid, and Bak; however, it certainly caused a decrease in the expression of antiapoptotic proteins, such as Mcl-1 and Bcl-XL (Fig. 3C).
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PMC11756937
In addition, it has been demonstrated that in early passages, episomally reprogrammed iPSCs become transgene-free .
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PMC7229095
Set up for transfection, semi-solid media optimization, mini-pool screening, and single cell cloning media development were performed, and final clones were obtained with higher productivity in fed-batch culture mode using rich formulated media comparing with lean formulated media.
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PMC11791264
Here, we report that SETD7 interacts with the autophagy protein LC3B.
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PMC11611077
The expression of His-tagged prestin in CHO cells was examined by Western blotting and immunofluorescence experiments.
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PMC8041314
Slopes from the linear fluorescence increase were calculated and compared to the respective slopes of the standard inhibitors.
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PMC11467800
For the angiogenesis assay, the larvae were embedded in %3 methylcellulose with tricaine before the injection.
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PMC8633974
Therefore, we posit that TatDE CRISPR therapy may similarly compromise latent HIV-1 sequences, thereby inducing immune-mediated clearance in vivo.
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PMC10812665
After 1 h, they were treated with the test compound for 24 h. Then, medium was replaced with Agilent Seahorse XF DMEM medium, pH 7.4, supplemented with 18 mM glucose, 2 mM glutamine and 1 mM pyruvate.
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PMC11643491
Along with the specific biological receptors that mediate phagocytosis , it has been shown that the mechanical state of macrophages, a key type of phagocyte, can also affect their capacity for particle uptake .
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PMC9429973
Il2rg (NSG) mice.
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PMC10291556
We show in this work that the Pt(IV) complexes combining Pt(II) complex 1 and DCF effectively induce hallmarks of ICD in cancer cells and promote phagocytosis of tumor cells.
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PMC11402217
Stable placement confirmed accurate needle positioning.
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PMC4485786
TCRVα24 mRNA expression in A204 tumors detected as a single peak or in Gaussian distribution. (
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PMC11351758
Their counterparts, 143B osteosarcoma cell lines, are the parental cell lines used for comparison.
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PMC9429973
Aims: To develop B-cell MRD Assay, a CAP/CLIA-accredited NGS-based MRD Laboratory Developed Test (LDT) to detect malignant B-cells at sensitivity up to 1.0 x 10.
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PMC8303372
The toxicity induced by GA-NPs 500 µmol/L is similar to that induced by the non-conveyed drug at the same concentration.
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PMC11300639
The length and width of the tumor were measured with vernier caliper every 2 days, and the tumor volume was calculated according to the formula (L × W)/2.
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PMC4369959
In support of this, another study showed that ginger reverses cisplatin-induced delay in gastric emptying indicating that ginger acts as an antiemetic for cancer chemotherapy .
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PMC11283030
ACLY is correlated with immune infiltrates in ccRCC.
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PMC9429973
Results: The frequencies of the minor alleles of rs1045485, rs13006529 and rs2234767 SNPs of Casp8, Casp10 and FAS genes, respectively, were significantly increased in ALL patients compared to controls.
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PMC11543853
The involvement of membrane rupture in enterovirus infection under a low multiplicity of infection conditions is corroborated by the blockage of enterovirus infection by wiskostatin—an inhibitor of post-endocytic membrane remodeling, as is discussed below.
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PMC11513011
Mice were also weighed for safety assessment.
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PMC11711345
A threshold is considered when the value Pa is equal to Pi.
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PMC10988808
B, D Representative immunoblots of biomarkers of the Hippo pathway, using ACTIN as reference.
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PMC11419566
Research by Gao et al showed that PA arrested cell cycle in the G1 phase by affecting COX-2/β-catenin pathway.
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PMC10976516
On the other hand, efficient transport to the tumor bed and oncolytic activity are made possible by viruses being protected by an appropriate protective carrier, such as mesenchymal stem cells (MSCs).
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PMC11300639
The staining intensity scores were as follows: 0 (no staining), 1 (light yellow = weak staining), 2 (yellow brown = moderate staining), 3 (brown = strong staining).
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PMC11794568
These findings suggest that CRIP1 inhibits mitochondrial biogenesis in cutaneous melanoma cells.
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PMC10094712
The reaction was carried out in the presence of oligo(dT) primers.
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PMC11799978
Meanwhile, it is no longer feasible to regulate CAFs by inhibiting a single molecule or a single signaling pathway to achieve a clinically effective overall tumor suppression.
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PMC11266100
Next day cells electrotransfected with pEGFP-N1 plasmid were detached using Trypsin-EDTA solution, centrifuged (400 × g for 5 min), resuspended with 70 μL PBS and further assessed by flow cytometry (BD Accuri C6).
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PMC11766350
Supernatants were aspirated and stored at −80 °C until further analysis.
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PMC10213179
Finally, cells were washed again with cold PBS before collection.
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PMC11216402
Despite advances in early diagnosis and treatments, the overall 5-yr survival rate is still ∼30% (Badgwell et al. 2017).
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PMC10578720
Activated macrophages commonly undergo glucose metabolism reprogramming to meet the bioenergetic needs of the macrophages during the immune response.
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PMC9429973
The key secondary end point was OS, which was an event-driven, pre-specified, alpha-controlled analysis in the intention-to-treat population, with a prespecified interim analysis after 103 deaths.
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PMC11700165
Most BTK-SYK appeared perinuclearly, whereas TEL-SYK was predominantly cytoplasmic (Fig. 3A), as previously reported.
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PMC11604768
a Heatmap of fold change responses in HEK293 cells across ten stimulus conditions relative to untreated cells.
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PMC10823017
Treatment with only ICA-1 (10µM) induced 11% early apoptosis.
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PMC9429973
Comparing MPN patients to matched controls, there was no difference in the types of non-MPN cancer, treatment exposures, or latency time.
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PMC10079526
Bioluminescence (BLI) was measured to visualize tumor growth.
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PMC9429973
Patients with deficient vitD levels had a significant higher risk of MIO than patients with adequate vitD levels (odds ratio-OR=20.62, 95%CI=2.67-153.72; P=0.004) and patients with insufficient VitD levels (OR=8.49, 95%CI=2.46-29.29; P=0.001).
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PMC10654497
Volcano plot quantifying the differentially expressed genes between subtypes C1 and C2. (
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PMC6461034
Discard PBS and leave dishes in tilted position for 1 min, and then remove remaining PBS with a Pasteur pipette.
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PMC11322866
ribonucleotide reductase regulatory subunit M2 (RRM2) is a major chromosomal instability gene associated with the cell cycle [ 31‒ 33] .
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PMC10547921
However, the interim phase 1 clinical data of ovarian cancer showed that XMT-1536 could cause serious treatment-related side effects, with an incidence of up to 48% (47/97).
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PMC10380508
After blocking, the membrane was incubated in primary antibody diluted in blocking buffer (with the addition of 0.1% sodium azide) overnight at 4 °C.
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PMC10198699
In 2018, the South African Minister of Health promulgated a material transfer agreement (MTA) to be used whenever biospecimens are transferred for purposes of research or clinical trials within or out of South Africa (SA MTA).
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PMC11348300
Ovarian and hypopharyngeal tumors also displayed reactivity to PRESTO but did not exhibit any contrast prepalpation.
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PMC11713588
Lead compounds were further characterized for CNS drug‐like properties including PK, metabolism, brain penetration, and are currently being evaluated in selectivity, and safety assays.
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PMC11453018
E The Lasso Cox regression model correlates gene expression with overall survival, assigning risk scores based on gene expression levels.
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PMC11380329
As a result more than 300 different components have been previously identified in propolis collected from different regions.
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PMC9812014
Other compounds like desethylamodiaquine, mefloquine, and quinine also showed good repressive activities with EC50 values of 0.52 μM, 1.8 μM, and 10.7 μM. These results suggest that these compounds can be effective in inhibiting this rapidly mutating infectious virus .
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PMC9429973
Further, flow cytometric analysis revealed that surface gp130 expression was significantly upregulated in resistant cell lines.
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PMC9261184
A better understanding of methane emissions and their sources/causes on different ships is required to identify the best methods to reduce emissions.
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PMC9429973
The secondary outcome was safety.
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PMC9429973
We mourn 6 deaths: 5 deaths were related to hematological malignancy, and 1 was related to opportunistic infections complicating HIV after poor adherence to ARVs.
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PMC6160470
On the contrary, the co-treatment with PTX and DAC-2Amide or DAC-3Amide, induced a notable G2/M arrest, along with the increase of subG1 population, indicative of cell death (Fig. 3d and Supplementary Fig. S11).
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PMC8998437
The copy numbers of the CCR1 and TBP transcripts were determined by quantitative real-time RT-PCR.
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PMC9516447
Other agents capable of suppressing or inhibiting GRP78 have been reported and are in clinical development or use .
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PMC9429973
Increasing levels of D-d at an ICU admission were associated with a slightly increased likelihood of exhibiting those events (relative risk=1.000051750).
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PMC11499381
Data analysis was performed using Signals ImageArtist software (Revvity) using images captured at 20x magnification.
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PMC9429973
Hematological findings showed that the number of white blood cells and platelets as well as hemoglobin in patients was significantly different from healthy individuals (P <0.05).
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PMC11756514
For the membrane-bound CTLs, the HEK293 cell line was employed to generate cell lines constitutively expressing either langerin or MGL; a cell line transfected with an empty vector served as a negative control.
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PMC8922418
Targeting the HIV-1 RNA genome or provirus.
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PMC11711663
Fig. 6Nomogram from the fitted Cox model.
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PMC7351993
The evaluation results yielded a sort purity and yield of 32.1% and 46.2%, respectively (Supplementary Fig. 8b).
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PMC7057940
Using a stereoscope, solid tumors were fractionated mechanically with scissors or a scalpel.
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PMC9429973
Results: We confirmed reduced density of sympathetic noradrenergic innervation in the BM of AML mice; however, interestingly, the cholinergic innervation, which also has sympathetic origin (Cell Stem Cell, in press) was preserved.
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