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OTAR3088
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PMC11470381
Utilize Covert to Mask and background = dark to generate binary masks of the cells, where darker regions (object of interest/cells) are interpreted as foreground while brighter regions are designated as image background (pixel values: 0 for background, 255 for foreground, for an 8-bit image) (Figure 3).
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PMC11672881
The RNAseq data and metabolomic analysis indicated changes in the redox states, which can lead to oxidative stress and trigger apoptosis in cancer cells.
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PMC11534377
The optical signal was subsequently normalized to the average radiance, expressed in photons per second per square centimeter per steradian (p/s/cm2/sr).
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PMC11742047
The color indicates fold change between the two conditions.
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PMC9812014
In in vitro evaluation investigations, this alkaloid demonstrated inhibitory efficacy against HIV with an EC50 of 0.10 μg/mL. Its therapeutic index was also greater than 1000, indicating that this alkaloid has a high potential for development as an anti-HIV medication .
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PMC7840816
Wnt proteins bind to the frizzled receptor, subsequently activate disheveled, and then result in stabilization and translocation of β-catenin into the nucleus.
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PMC11190062
To obtain an overview of TLR expression in primary MM cells, we examined TLR mRNA expression in CD138 cells obtained from 772 patients at diagnosis (CoMMpass IA14).
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PMC8973085
Methyl iodide (15 mmol) was added to a stirred solution of compound 3a or 3b (10 mmol) and potassium hydroxide (10 mmol) in dichloromethane (75 mL) and stirred for another 6 h at room temperature.
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PMC10818573
EBV infection involves many organ systems and is often misdiagnosed or underdiagnosed.
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PMC11286266
Gating for live cells was based on FSC-A/SSC-A and for singlets was based on FSC-W/SSC-A. BiP::sfGFP and mGreenLantern (mGL) fluorescent signals were detected with an excitation laser at 488 nm and a 530/30 nm emission filter; XBP1s::mCherry fluorescence with an excitation laser 561 nm and a 610/20 nm emission filter, while mTurquoise and BFP fluorescence with an excitation laser 405 nm and a 450/50 nm filter emission.
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PMC9429973
Results: As expected, BM Tfr2 deficiency strongly ameliorated anemia and IE of Hbb mice (hemoglobin, Hb=13.48±0.19g/dL vs 8.65±0.24g/dL in controls, P<0.000001).
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PMC11521786
DU145 is a prostate tumor cell line resistant to androgen deprivation therapy (ADT), while both PC9ER and H1975 express the EGFR-T790M mutation that predicts resistance to first-generation anti-HER1-TKI.
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PMC11513571
PBMC were stained with anti-human CD3-PE antibody and gated from the lymphocyte population to determine the cell depletion was performed properly.
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PMC11190062
We found that overall, TLR1, TLR4, TLR6, TLR9, and TLR10 were the most highly expressed (median cpm > 2) in this cohort.
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PMC9429973
The outcome of AML remains highly unsatisfactory in the elderly due to disease-related and patient-related differences between younger and older patients.
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PMC11502443
Plasmid DNA was purified using the NucleoBond Xtra Maxi kit (Macherey-Nagel, Germany) and sequenced prior to use (Centre for Genomics, Proteomics and Metabolomics, University of Auckland).
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PMC11730311
Six-week old male NMRI mice were obtained from Janvier (France).
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PMC9429973
Disease status at Haplo-SCT was CR, PR, marrow CR and active disease in 12, 2, 1 and 7 patients, respectively.
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PMC11347429
Transcriptome analyses and genotype analyses were performed in several batches, which required batch corrections.
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PMC10994876
YAP contains five HXRXXS motifs, which are phosphorylation sites for LATS kinases (Zhao et al. 2010).
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PMC11321678
This approach was previously validated in with matched whole exome sequencing data from an earlier study in two patient samples.
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PMC11473750
Neuroblastoma cell lines, Kelly, CHP-134, SK-N-DZ, and SK-N-AS cells were obtained from the European Collection of Cell Cultures through Sigma (Sigma, Sydney, Australia).
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PMC9429973
We sought to utilize a machine learning approach to identify clinical and demographic features associated with patient responses to multiple myeloma induction therapy and ASCT Aims: We aimed to employ machine learning analysis in the identification of clinical and demographic characteristics associated with patients’ response to multiple myeloma induction therapy and ASCT Methods: A retrospective chart review of patients with a documented diagnosis of multiple myeloma seen at the University of Arizona Cancer Center between January 2017 and April 2021 was performed.
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PMC9429973
In the past, Colombo et al. demonstrated suppressed TE expression in higher risk MDS in a small cohort of patients.
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PMC9429973
Chemomobilization with cytarabine and G-CSF seem to overcome poor mobilization and collection yields for this patient group.
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PMC9429973
Ethics approval was obtained.
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PMC11551844
Recently, Rizki et al. (2023) have provided a comprehensive review of the synthesis of silver and AuNPs from marine organisms.
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PMC11087766
PhiKZ gp104-sfGFP and gp171-sfGFP do not concentrate in the mutant nucleus until 15 mpi or later (Fig. 3 E–G).
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PMC11585565
Experimental workflow for determining the decay rates of wild-type and mutant CNNM4 mRNA and CNNM4 protein (created with BioRender.com).
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PMC9429973
Greater benefits were observed with longer Tx duration.
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PMC11745600
Insulin sensitivity was assessed via tolerance tests.
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PMC11683240
However, determination of IC50 values showed that when labeled PT was preincubated with α1AT, binding IC50 values were more than two-fold lower compared to when labeled PT and α1AT were added directly to cells (Fig. 5, H and I).
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PMC11045125
The heatmap of viral transcripts was constructed by using the TPM (transcripts per million) values estimated by RSEM.
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PMC8193046
From these 846 potential broad-spectrum ABCB1, ABCC1, and ABCG2 inhibitors we manually selected and purchased 10 candidates (compounds 16–25; Fig. 5) depending on manner and number of extended positive hits present and general molecular composition, as well as commercial availability and affordability at MolPort® (www.molport.com).
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PMC11585565
Fig. 3Determination of the wild-type and mutant mRNA and protein turnover rates. (
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PMC9429973
Six (18%) patients had kidney transplants prior to the diagnosis of CM-TMA and 4 (12%) patients required renal transplant after receiving C5-mab.
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PMC11322866
Phosphorylated EZH2 acts as a tumor suppressor, resulting in the inhibition of its own methyltransferase function .
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PMC11673128
Beyond previous findings, we showed for the first time that this combined treatment is effective not only in TKIs-sensitive setting, but also in resistant ones, particularly in cases with bypass resistance mechanisms, a major challenge in maintaining ALKi efficacy.
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PMC11266100
However, when exposed to increased amplitudes, such as 1.5 kV/cm with 100 µs pulses, a notable reduction in viability can be seen (Figure 3).
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PMC11188874
Peptides were eluted from the class I molecules and sequenced by MS (29).
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PMC11790971
In the following sections, further analyses were conducted to provide a quantitative investigation into the importance of various features and optical characteristics associated with the different cell lines.
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PMC8193046
Besides pyrimidine and pyridine, we identified 14 more substructures from the initial data set of 1,049 compounds that should be reconsidered in terms of multitarget ABCB1, ABCC1, and ABCG2 inhibition in particular, and pan-ABC transporter inhibition in general: (i) aniline; (ii) benzoyl; (iii) benzyl; (iv) cyano; (v) 9-deazapurine; (vi) ether; (vii) ethylenediamine; (viii) methoxy; (xiv) methoxyphenyl; (x) phenol; (xi) phenyl; (xii) piperazine; (xiii) pyrrole; and (xiv) resorcin.
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PMC11095939
In this study, we discovered that Mecp2-mediated transcriptional activation of genes involved in metabolism is one of the mechanisms that prevents exit from quiescence.
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PMC9220170
Previously, we have shown that the level of SELENOM and SELENOT mRNA expression and the amount of proteins changed depending on the concentration and nature of the ER stress source in various human cancer cell lines .
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PMC11012313
Finally, our laboratory has demonstrated that PI3K signaling induced by LMP2A can promote STAT3 activation, that also contributes to cellular survival .
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PMC11045125
The EBV-positive Akata Burkitt lymphoma cell line was originally derived by the Takada lab .
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PMC11225860
Additionally, alisertib treatment induces an aggressive growth phenotype, as they can undergo G1 cell cycle slippage, thus shortening the overall cell cycle.
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PMC10142392
In addition, predetermined morphologies can be targeted by controlling the degree of polymerization (DP) of the hydrophilic and hydrophobic monomers during synthesis.
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PMC11391695
A pathological examination was performed on each tissue prior to its storage at − 80 °C for subsequent analysis.
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PMC9429973
Material from 13 matched pairs of PDXs (RNA, cells) was used for multi-omic analyses, including DNA-Seq (WES), RNA-Seq, ATAC-Seq and methylation analysis with EPIC arrays.
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PMC10243817
Edema was semiquantitatively scored on a 3-point scale, with 0 representing the lowest and 2 representing the highest scores, as mentioned elsewhere (22).
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PMC11511922
Exosomes (EVs) were labeled with PHK67 (green) and the DNA core was stained with Hoechst 33342 (blue).
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PMC11753435
All graphs were generated using Prism 9 for MacOS version 9.2.0.
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PMC9019892
Fibroblast growth factors and receptors (FGFR1–4) are involved in the regulation of cell survival and proliferation and angiogenesis .
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PMC5600151
Different groups have conjugated a PEG block on PLL dendrimers, showing that an appropriate portion of PEG stabilized the dendrimer/DNA complex structures without affecting the DNA complexing ability .
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PMC5415764
To determine the cellular accumulation of PTX mediated by P-gp inhibition due to TET and iRGD LPN incorporation, the A2780/PTX cell uptake of PTX in various formulations was determined by HPLC.
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PMC4485648
Sulforaphane was obtained from Sigma-Aldrich (St. Louis, MO, USA) and used at 2.5–10 μM depending on the experimental setting.
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PMC10577955
It is native to the Mediterranean region and distributed in the western Mediterranean region of Egypt .
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PMC11774251
Additionally, while we demonstrated Tan-I’s potential therapeutic effects, further investigation is needed to elucidate its long-term efficacy, potential side effects, and precise molecular mechanisms in human psoriasis.
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PMC11365983
Fig. 7Dysregulated Hedgehog signaling in the meninges of Foxc1 mutant embryos. (
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PMC10197932
On the contrary, Jurkat cells have a little increase (about 1.5-fold) of Mcl-1L during first 30 min after US-treatment respect to UT cells, and an increase (about 1.7-fold) of Mcl-1s (Figure 9P and Figure S1).
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PMC10854447
Inhibiting VEGFR-2 has been proposed as an effective method for preventing angiogenesis.
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PMC6642070
It is also consistent with previous findings that glycolytic muscles are more affected by statins .
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PMC11761919
The samples were lyophilized and stored at -20 °C until use.
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PMC9428827
Seven- to eight-week-old female C57BL/6 and BALB/c mice were obtained from The National Center for Laboratory Animal Breeding (Havana, Cuba), Animal Resources Centre, IBS Pohang Institute of Basic Science (Pohang, Korea), or Instituto Gulbenkian de Ciencia (Oeiras, Portugal).
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PMC11577421
Additionally, we confirmed that MTX does not inhibit clathrin-dependent endocytosis, nor does it impair general fluid phase endocytosis or macropinocytosis more specifically (Suppl.
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PMC7192625
The tool-tip will show the exact value for the feature on the node and the range of feature values in the whole network for comparison.
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PMC11012012
Moreover, an anti-human SLAMF6/CD352 monoclonal antibody efficiently killed human CLL cells both in vitro (in combination with ibrutinib, it induced apoptosis in OSU-CLL cells) and in vivo (it reduced the growth of MEC-1 cells transplanted subcutaneously into [Rag x γc] mice).
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PMC11412721
Evidence for Myc binding at the Mt2 promoter in B cells.
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PMC11319300
Therefore the lack of promoter chromatin signals suggests that MYEOV-3′-putative enhancer activity is independent of MYEOV’s gene promoter activity (Figure 1; Supplementary Figure S1).
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PMC11803149
Adoptive transfer was performed by intravenously injecting cells including 10 GFP cells after GFP expression was assessed by flow cytometry.
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PMC10530622
Curiously, Slc26a6-deficient mice had hyperreninemia and higher serum succinate levels, which contribute to blood pressure regulation by inducing renin release via the activation of a G-coupled protein receptor in the juxtaglomerular apparatus.
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PMC11686380
The intensity ratio in the contralateral side to the corresponding ipsilateral side was calculated.
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PMC10530622
In fact, factors associated with oxaluria and oxalemia have been ascertained in different populations; a few among the more recent follows.
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PMC7802142
n ≥ 4; *P < 0.05, **P < 0.01, ***P < 0.001 versus the PBS groups by One-way ANOVA ReN-NV enter into DPCs and promote their proliferation.
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PMC9429973
Aims: To evaluate the response of renal impairment due to leukemic infiltration and due to MPGN as well as disease response, after specific treatment, compared with literature data.
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PMC11489351
We note that MCF10A cells do not express estrogen receptors and express high molecular weight keratins (24), which mark MCF10A as having a “basal epithelial” phenotype (25) and not a luminal epithelial phenotype (26).
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PMC10530622
Hypermethylation was also observed, as well as the decrease in AGXT mRNA levels in steatotic donors.
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PMC11643361
This is particularly relevant as breast cancer cells often exhibit resistance to apoptosis, and the ability of complex 34 to induce paraptosis highlights its potential as a novel therapeutic agent.
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PMC9429973
Methods: This Phase II, non-randomized, multicenter, open-label study (NCT03988608) enrolled Chinese adult patients (≥18 yrs) with R/R SAA.
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PMC11476222
By employing various chromatographic columns and mobile phase compositions, efficient separation of gangliosides and their isomers is feasible, with reduced interference from other lipid species or biomolecules in the biological sample .
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PMC11286266
As expected, the deletion of ATF6α resulted in the loss of the BiP::sfGFP signal in stressed cells (and enhanced XBP1s::mCherry signal in basal conditions, Figure 5A).
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PMC11295144
These in vitro findings are supported by the in vivo evidence from GABAAR α1, α3 or γ2 subunit knock-out mice demonstrating that the lack of these subunits in certain brain regions leads to prominent structural changes in specific types of inhibitory synapses (Schweizer et al., 2003; Li et al., 2005; Fritschy and Panzanelli, 2006; Studer et al., 2006).
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PMC9429973
Ninety percent of patients developed cytokine release syndrome (CRS), mostly on the day of cell infusion (median day 0, range 0-21), while none suffered from grade 3-4 CRS.
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PMC9080589
Taken together, these findings showed that overexpression of PCDH8 inhibits proliferation and migration/invasion, and induces apoptosis of PTC cells through the Wnt/β-catenin signaling pathway.
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PMC11747949
Calculated values were used for multiple variable analysis (all calculated values are represented in Supporting Information Table S1, raw blots in Figure S1).
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PMC11513011
The percentage of positive cells was evaluated on a three-point scale of 1 (0–10%), 2 (11–50%), and 3 (50% or more).
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PMC8348645
The methanolic extracts of the plant samples were subjected to HPLC analysis at 254 nm.
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PMC11530949
Comparative analysis showed that the IC50 values of the Ag-doped CuO NPs were significantly lower than that of the plant extracts.
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PMC11789597
Among them, CXCL10 was increased fivefold by CAV1 inhibition.
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PMC11742047
CBD is a non-psychoactive compound present in Cannabis sativa L., which has shown an antiproliferative action in these type of cancer cells.
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PMC11575040
In addition, LC3 and ATG5 knockdown reduced the degree of apoptosis and inhibited the antiproliferative effect of metformin on melanoma cells, thereby inhibiting autophagy.
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PMC11765243
Blast cell lysis was performed at 2 × 10 cells /mL, and post-nuclear lysates mixed V:V with a 2× SDS-PAGE sample buffer.
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PMC11359735
The hydrolysates were removed from the PVDF strips, dried and derivatized with trimethylsilyl (TMS) reagent prior to analysis by gas chromatography-mass spectrometry (GC-MS) in selected ion monitoring (SIM) mode to quantitate free myo-inositol released from the PVDF membrane strips, (Fig. 3B).
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PMC4443654
Each variable region is also shown individually in Additional file 1: Figure S11.
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PMC11768281
However, their activity can be modulated or suppressed by γδ T cells, underscoring the complex interplay of immune components in shaping the host response to malaria .
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PMC9429973
with AAMT based on bone marrow finding who had been diagnosed and/or treated between January 2011 and December 2021 at the (NCCCR) in Qatar.
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PMC11683130
Ang II induces reactive oxygen species (ROS) production by stimulating NADPH oxidase (NOX) (47, 173).
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PMC11637716
, a height of 40 cm (<3.
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PMC11721295
The KRAS inhibitors sotorasib and adagrasib have gained FDA approval for lung cancer, while MRTX1133, a KRAS inhibitor, has entered phase I/II clinical testing for malignancies, including G12D-mutant lung cancer.
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