Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC11673128
The upregulation of CALR was assessed using flow cytometry (FC) after exposing cell lines to TKIs for 20 h, as previously shown .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "upregulation", "of", "CALR", "was", "assessed", "using", "flow", "cytometry", "(", "FC", ")", "after", "exposing", "cell", "lines", "to", "TKIs", "for", "20", "h", ",", "as", "previously", "shown", "." ] } ]
PMC10812665
Metabolic effects relating to the latter have been linked to human epilepsies .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metabolic", "effects", "relating", "to", "the", "latter", "have", "been", "linked", "to", "human", "epilepsies", "." ] } ]
PMC11743316
Proteins that suppress apoptosis, such as B-cell lymphoma-2 (Bcl-2) and B-cell lymphoma-extra-large (Bcl-xL), exist in mitochondrial outer membranes and block cytochrome c release .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "that", "suppress", "apoptosis", ",", "such", "as", "B-cell", "lymphoma-2", "(", "Bcl-2", ")", "and", "B-cell", "lymphoma-extra-large", "(", "Bcl-xL", ")", ",", "exist", "in", "mitochondrial", "outer", "membranes", "and", "block", "cytochrome", "c", "release", "." ] } ]
PMC11799620
After incubation for 24 hours, the absorbance read at 570 nm against control cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "incubation", "for", "24", "hours", ",", "the", "absorbance", "read", "at", "570", "nm", "against", "control", "cells", "." ] } ]
PMC10523483
H1C expression in poorly/moderately differentiated tumors (n = 33) and well-differentiated tumors (n = 7), samples were grouped according to clinical diagnosis. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H1C", "expression", "in", "poorly/moderately", "differentiated", "tumors", "(", "n", "=", "33", ")", "and", "well-differentiated", "tumors", "(", "n", "=", "7", ")", ",", "samples", "were", "grouped", "according", "to", "clinical", "diagnosis", ".", "(" ] } ]
PMC11699178
Moreover, due to chemotherapy resistance, the recurrence rate of ovarian cancer is also high .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "due", "to", "chemotherapy", "resistance", ",", "the", "recurrence", "rate", "of", "ovarian", "cancer", "is", "also", "high", "." ] } ]
PMC9429973
Results: LFPRLR knockdown reduced splenic B cell numbers in SLE-prone mice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "LFPRLR", "knockdown", "reduced", "splenic", "B", "cell", "numbers", "in", "SLE-prone", "mice", "." ] } ]
PMC11753435
To assess whether PepPrCLIP-designed peptides, when integrated into the uAb architecture, can induce target degradation of the SS18-SSX1 protein, whose sequence is neither within PepPrCLIP’s training set nor within ESM-2-650M’s training set (47), we first cloned the fusion in frame with the mCherry fluorescent protein and ectopically expressed the construct in HEK293T cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "To", "assess", "whether", "PepPrCLIP-designed", "peptides", ",", "when", "integrated", "into", "the", "uAb", "architecture", ",", "can", "induce", "target", "degradation", "of", "the", "SS18-SSX1", "protein", ",", "whose", "sequence", "is", "neither", "within", "PepPrCLIP", "’s", "training", "set", "nor", "within", "ESM-2", "-", "650", "M", "’s", "training", "set", "(", "47", ")", ",", "we", "first", "cloned", "the", "fusion", "in", "frame", "with", "the", "mCherry", "fluorescent", "protein", "and", "ectopically", "expressed", "the", "construct", "in", "HEK293", "T", "cells", "." ] } ]
PMC11742231
In this context, several machine learning algorithms have been employed, including linear regression , decision trees , random forests , support vector machines (SVMs) , and neural networks [16–21].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "context", ",", "several", "machine", "learning", "algorithms", "have", "been", "employed", ",", "including", "linear", "regression", ",", "decision", "trees", ",", "random", "forests", ",", "support", "vector", "machines", "(", "SVMs", ")", ",", "and", "neural", "networks", "[", "16–21", "]", "." ] } ]
PMC10452486
Antoniou et al. studied the formation of B27-Face-3 and the relationship to assembly kinetics.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antoniou", "et", "al.", "studied", "the", "formation", "of", "B27-Face-3", "and", "the", "relationship", "to", "assembly", "kinetics", "." ] } ]
PMC11779605
The FGF7 protein is secreted by fibroblasts and induces growth, differentiation, and angiogenesis in epithelial cells and tumors (28) consistent with its alternate name of keratinocyte growth factor (KGF).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FGF7", "protein", "is", "secreted", "by", "fibroblasts", "and", "induces", "growth", ",", "differentiation", ",", "and", "angiogenesis", "in", "epithelial", "cells", "and", "tumors", "(", "28", ")", "consistent", "with", "its", "alternate", "name", "of", "keratinocyte", "growth", "factor", "(", "KGF", ")", "." ] } ]
PMC11591038
In this regard, iron chelation may be considered a therapeutic option for AD .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "regard", ",", "iron", "chelation", "may", "be", "considered", "a", "therapeutic", "option", "for", "AD", "." ] } ]
PMC8303372
After 72 h, the precipitated polymer was recovered by centrifugation (14.000 rpm, 20 min), washed three times with water and freeze-dried.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "72", "h", ",", "the", "precipitated", "polymer", "was", "recovered", "by", "centrifugation", "(", "14.000", "rpm", ",", "20", "min", ")", ",", "washed", "three", "times", "with", "water", "and", "freeze-dried", "." ] } ]
PMC10079526
The PANTHER overrepresentation test (released 2022-02-02) was used, GO Ontology database DOI: 10.5281/zenodo.6399963 released 2022-03-22.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PANTHER", "overrepresentation", "test", "(", "released", "2022", "-", "02", "-", "02", ")", "was", "used", ",", "GO", "Ontology", "database", "DOI", ":", "10.5281/zenodo.6399963", "released", "2022", "-", "03", "-", "22", "." ] } ]
PMC11673902
Due to the relatively weak hydrophobic/hydrophilic interactions of the cell membrane’s phospholipid bilayer, this electric field creates temporary holes in the phospholipid bilayer of the cell membrane .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "the", "relatively", "weak", "hydrophobic/hydrophilic", "interactions", "of", "the", "cell", "membrane", "’s", "phospholipid", "bilayer", ",", "this", "electric", "field", "creates", "temporary", "holes", "in", "the", "phospholipid", "bilayer", "of", "the", "cell", "membrane", "." ] } ]
PMC5673955
These results indicate the mechanism of telomerase suppression is different from direct inhibition of the telomerase complex.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicate", "the", "mechanism", "of", "telomerase", "suppression", "is", "different", "from", "direct", "inhibition", "of", "the", "telomerase", "complex", "." ] } ]
PMC9429973
The following subpopulations of PBMC from 6 HD: CD4, CD8, CD45RO, CD45RA, CD31, CD56, CD14, CD19 were separated by PE-conjugated antibody staining and positive selection on magnetic beads.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "following", "subpopulations", "of", "PBMC", "from", "6", "HD", ":", "CD4", ",", "CD8", ",", "CD45RO", ",", "CD45RA", ",", "CD31", ",", "CD56", ",", "CD14", ",", "CD19", "were", "separated", "by", "PE-conjugated", "antibody", "staining", "and", "positive", "selection", "on", "magnetic", "beads", "." ] } ]
PMC11351758
Hence, we then explored how mitochondrial calcium overload [Ca]m modulates high glucose toxicity on the respiratory chain defect-augmented mitochondrial reactive oxygen species (ROS) production and membrane potential (ΔΨ) depolarization in parental 143B cells and NARP cybrids under antioxidant conditions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "we", "then", "explored", "how", "mitochondrial", "calcium", "overload", "[Ca]m", "modulates", "high", "glucose", "toxicity", "on", "the", "respiratory", "chain", "defect-augmented", "mitochondrial", "reactive", "oxygen", "species", "(", "ROS", ")", "production", "and", "membrane", "potential", "(", "ΔΨ", ")", "depolarization", "in", "parental", "143B", "cells", "and", "NARP", "cybrids", "under", "antioxidant", "conditions", "." ] } ]
PMC9954564
In contrast, some modifications are observed in the MB-MDR method .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "some", "modifications", "are", "observed", "in", "the", "MB-MDR", "method", "." ] } ]
PMC11365427
BM samples were separated into BM supernatant and BM cells, both of which were analyzed for metabolic changes using untargeted metabolomics.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BM", "samples", "were", "separated", "into", "BM", "supernatant", "and", "BM", "cells", ",", "both", "of", "which", "were", "analyzed", "for", "metabolic", "changes", "using", "untargeted", "metabolomics", "." ] } ]
PMC11566417
3Mammosphere derived epithelial cell (MDEC) culture growth kinetics and cell composition are variably affected by immortalization and passage.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3Mammosphere", "derived", "epithelial", "cell", "(", "MDEC", ")", "culture", "growth", "kinetics", "and", "cell", "composition", "are", "variably", "affected", "by", "immortalization", "and", "passage", "." ] } ]
PMC6222726
Notably, all the examined Elaphrium subgenus species produce only dibenzyl butyrolactones and picro aryltetraline derivatives, whereas Bursera subgenus produce all lignan types.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "all", "the", "examined", "Elaphrium", "subgenus", "species", "produce", "only", "dibenzyl", "butyrolactones", "and", "picro", "aryltetraline", "derivatives", ",", "whereas", "Bursera", "subgenus", "produce", "all", "lignan", "types", "." ] } ]
PMC11541241
Moreover, they observed that the expression level of MoSNT2 was dependent on MoTOR, and MoSNT2‐mediated infection‐associated autophagy and autophagic pathogenic growth through coordination with the MoTOR kinase pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "they", "observed", "that", "the", "expression", "level", "of", "MoSNT2", "was", "dependent", "on", "MoTOR", ",", "and", "MoSNT2‐mediated", "infection‐associated", "autophagy", "and", "autophagic", "pathogenic", "growth", "through", "coordination", "with", "the", "MoTOR", "kinase", "pathway", "." ] } ]
PMC9429973
Immune cell subset counts of B cells, T cells, monocytes, dendritic cells (DCs), myeloid-derived suppressor cells, natural killer cells, and innate lymphoid cells were calculated and compared to those of 20 age-matched healthy donors.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immune", "cell", "subset", "counts", "of", "B", "cells", ",", "T", "cells", ",", "monocytes", ",", "dendritic", "cells", "(", "DCs", ")", ",", "myeloid-derived", "suppressor", "cells", ",", "natural", "killer", "cells", ",", "and", "innate", "lymphoid", "cells", "were", "calculated", "and", "compared", "to", "those", "of", "20", "age-matched", "healthy", "donors", "." ] } ]
PMC9509578
In fact, a polymeric liposome was the first nanoformulation approved by FDA to be used as a nanotechnology-based anticancer therapeutic .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "a", "polymeric", "liposome", "was", "the", "first", "nanoformulation", "approved", "by", "FDA", "to", "be", "used", "as", "a", "nanotechnology-based", "anticancer", "therapeutic", "." ] } ]
PMC11321678
We found immune cell clusters were largely contributed by specific molecular subgroup, indicating that diverse macrophage subpopulations exist in four subgroups.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "immune", "cell", "clusters", "were", "largely", "contributed", "by", "specific", "molecular", "subgroup", ",", "indicating", "that", "diverse", "macrophage", "subpopulations", "exist", "in", "four", "subgroups", "." ] } ]
PMC9960565
It appears that fluorescence reached a maximum after the conjugation of the 16 metal complexes, decreasing in the next generation (G2.5(COOPt(NH3)2Cl)32).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "appears", "that", "fluorescence", "reached", "a", "maximum", "after", "the", "conjugation", "of", "the", "16", "metal", "complexes", ",", "decreasing", "in", "the", "next", "generation", "(", "G2.5(COOPt(NH3)2Cl)32", ")", "." ] } ]
PMC7338939
Although the high dose of DAPT is effective, the cytotoxicity may affect normal cells; (iii) resistance against Notch inhibitors may occur in the long term, leading to a more aggressive form of cancer with higher stem cell properties and metastasis; (iv) PI3K signaling, Wnt signaling pathways, and the other regulating networks may compensate the inhibition of Notch (41, 42, 50).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "high", "dose", "of", "DAPT", "is", "effective", ",", "the", "cytotoxicity", "may", "affect", "normal", "cells", ";", "(", "iii", ")", "resistance", "against", "Notch", "inhibitors", "may", "occur", "in", "the", "long", "term", ",", "leading", "to", "a", "more", "aggressive", "form", "of", "cancer", "with", "higher", "stem", "cell", "properties", "and", "metastasis", ";", "(", "iv", ")", "PI3", "K", "signaling", ",", "Wnt", "signaling", "pathways", ",", "and", "the", "other", "regulating", "networks", "may", "compensate", "the", "inhibition", "of", "Notch", "(", "41", ",", "42", ",", "50", ")", "." ] } ]
PMC9429973
Among 45 participants who experienced PC drops following D1+D2, PC drops were larger with: a) D1 in 13 (28%) b) D2 in 7 (16%), and c) the same following D1 and D2 in 25 (56%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "45", "participants", "who", "experienced", "PC", "drops", "following", "D1+D2", ",", "PC", "drops", "were", "larger", "with", ":", "a", ")", "D1", "in", "13", "(", "28", "%", ")", "b", ")", "D2", "in", "7", "(", "16", "%", ")", ",", "and", "c", ")", "the", "same", "following", "D1", "and", "D2", "in", "25", "(", "56", "%", ")", "." ] } ]
PMC11285179
The reporter plasmid was co-transfected with pRL-TK vector and CEBPB expressing pcDNA3.1 vector or control vector into A549 cell.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "reporter", "plasmid", "was", "co-transfected", "with", "pRL-TK", "vector", "and", "CEBPB", "expressing", "pcDNA3.1", "vector", "or", "control", "vector", "into", "A549", "cell", "." ] } ]
PMC11734514
These results suggested their promising candidacy for future anti-angiogenesis in anticancer therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggested", "their", "promising", "candidacy", "for", "future", "anti-angiogenesis", "in", "anticancer", "therapy", "." ] } ]
PMC11055323
N12 with R3A or K5A mutation loses that capability.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "N12", "with", "R3A", "or", "K5A", "mutation", "loses", "that", "capability", "." ] } ]
PMC11708541
Improvements in synthetic chemistry and drug delivery strategies will augment the medicinal potential of aminopyridines and pave the way for the development of more effective, targeted medications with reduced side effects and improved bioavailability.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Improvements", "in", "synthetic", "chemistry", "and", "drug", "delivery", "strategies", "will", "augment", "the", "medicinal", "potential", "of", "aminopyridines", "and", "pave", "the", "way", "for", "the", "development", "of", "more", "effective", ",", "targeted", "medications", "with", "reduced", "side", "effects", "and", "improved", "bioavailability", "." ] } ]
PMC11739484
Emerging approaches, including antibody-based therapies and novel delivery systems, aim to improve therapeutic precision, but their application in melanoma is still in its infancy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emerging", "approaches", ",", "including", "antibody-based", "therapies", "and", "novel", "delivery", "systems", ",", "aim", "to", "improve", "therapeutic", "precision", ",", "but", "their", "application", "in", "melanoma", "is", "still", "in", "its", "infancy", "." ] } ]
PMC5025404
The supernatant was removed by decantation, and the cells were suspended in FreeStyle™ CHO Expression Medium, containing 8 mM alanyl-glutamine (both reagents were from Invitrogen, USA) to a final density of 1.2–1.5 × 10 cells/mL. Further transfection was performed in 6-well plates, according to the manufacturer’s instructions (FreeStyle CHO-DG44 Cells, Invitrogen, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "was", "removed", "by", "decantation", ",", "and", "the", "cells", "were", "suspended", "in", "FreeStyle", "™", "CHO", "Expression", "Medium", ",", "containing", "8", "mM", "alanyl-glutamine", "(", "both", "reagents", "were", "from", "Invitrogen", ",", "USA", ")", "to", "a", "final", "density", "of", "1.2–1.5", "×", "10", "cells/mL.", "Further", "transfection", "was", "performed", "in", "6-well", "plates", ",", "according", "to", "the", "manufacturer", "’s", "instructions", "(", "FreeStyle", "CHO-DG44", "Cells", ",", "Invitrogen", ",", "USA", ")", "." ] } ]
PMC11792766
Additionally, the use of such combination of solvents must allow for the formation of a homogeneous exposure medium and, at feasible concentrations, should not exert background adverse effects to the biological system used for the investigation or the bioassays involved.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "use", "of", "such", "combination", "of", "solvents", "must", "allow", "for", "the", "formation", "of", "a", "homogeneous", "exposure", "medium", "and", ",", "at", "feasible", "concentrations", ",", "should", "not", "exert", "background", "adverse", "effects", "to", "the", "biological", "system", "used", "for", "the", "investigation", "or", "the", "bioassays", "involved", "." ] } ]
PMC10502403
NE1-GMCs induced antigen-specific apoptosis in NE1p157-pulsed target cells and NY-ESO-1HLA-A2 tumor cells (Figures S3A–S3C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NE1-GMCs", "induced", "antigen-specific", "apoptosis", "in", "NE1p157-pulsed", "target", "cells", "and", "NY-ESO-1HLA-A2", "tumor", "cells", "(", "Figures", "S3A", "–", "S3C", ")", "." ] } ]
PMC11568601
B After treatment with TGT (40, 60, or 80 mg·mL) for 24 h, the colony formation ability of the 143B and MG-63 cells was detected.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "B", "After", "treatment", "with", "TGT", "(", "40", ",", "60", ",", "or", "80", "mg·mL", ")", "for", "24", "h", ",", "the", "colony", "formation", "ability", "of", "the", "143B", "and", "MG-63", "cells", "was", "detected", "." ] } ]
PMC11342785
E, example image showing a recently divided cell where a bundled MT-architecture has reformed at the site of separation, indicating synMAP structures are compatible with mitosis and cell division.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", ",", "example", "image", "showing", "a", "recently", "divided", "cell", "where", "a", "bundled", "MT-architecture", "has", "reformed", "at", "the", "site", "of", "separation", ",", "indicating", "synMAP", "structures", "are", "compatible", "with", "mitosis", "and", "cell", "division", "." ] } ]
PMC11607764
The poor prognosis in lung cancer patients with higher PTBP1 expression (Figure 3B) was in line with the data from the Kaplan-Meier plotter analysis (Figure 3A, OS, P = 0.0000051; PPS, P = 0.00029; FP, P = 0.002).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "poor", "prognosis", "in", "lung", "cancer", "patients", "with", "higher", "PTBP1", "expression", "(", "Figure", "3B", ")", "was", "in", "line", "with", "the", "data", "from", "the", "Kaplan-Meier", "plotter", "analysis", "(", "Figure", "3A", ",", "OS", ",", "P", "=", "0.0000051", ";", "PPS", ",", "P", "=", "0.00029", ";", "FP", ",", "P", "=", "0.002", ")", "." ] } ]
PMC11568601
B The colony formation capacity of 143B cells was decreased upon IRE1 overexpression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "The", "colony", "formation", "capacity", "of", "143B", "cells", "was", "decreased", "upon", "IRE1", "overexpression", "." ] } ]
PMC9429973
Median duration of post splenectomy follow-up (FU) was 5.9 yrs (2.7-9.2) yielding 1192.6 patients-years (PY) of observation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "duration", "of", "post", "splenectomy", "follow-up", "(", "FU", ")", "was", "5.9", "yrs", "(", "2.7", "-", "9.2", ")", "yielding", "1192.6", "patients-years", "(", "PY", ")", "of", "observation", "." ] } ]
PMC11597291
GO was also investigated in thermally responsive formulations by Jedrzejczak-Silicka et al. .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "was", "also", "investigated", "in", "thermally", "responsive", "formulations", "by", "Jedrzejczak-Silicka", "et", "al.", "." ] } ]
PMC11747949
To assess 143B tumor growth in vivo under CCR2 inhibition, 143B cells were inoculated intraosseous into the right tibia of Nude mice.
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "143B", "tumor", "growth", "in", "vivo", "under", "CCR2", "inhibition", ",", "143B", "cells", "were", "inoculated", "intraosseous", "into", "the", "right", "tibia", "of", "Nude", "mice", "." ] } ]
PMC11585587
The study has showed that RA can inhibit proliferation and induce apoptosis by regulating the JNK and STAT3 signaling pathways in human osteosarcoma.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "has", "showed", "that", "RA", "can", "inhibit", "proliferation", "and", "induce", "apoptosis", "by", "regulating", "the", "JNK", "and", "STAT3", "signaling", "pathways", "in", "human", "osteosarcoma", "." ] } ]
PMC10706275
Nonetheless, a significant concern associated with these cells is the instability of protein expression over extended production periods .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ",", "a", "significant", "concern", "associated", "with", "these", "cells", "is", "the", "instability", "of", "protein", "expression", "over", "extended", "production", "periods", "." ] } ]
PMC11730000
Consequently, the IC50 value could not be calculated for the concentrations used in this study.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "the", "IC50", "value", "could", "not", "be", "calculated", "for", "the", "concentrations", "used", "in", "this", "study", "." ] } ]
PMC3122064
Finally, cells were stained with Hoechst 33258 (Molecular Probes, Invitrogen) for 5 min, washed with PBS, and coverslips were mounted on slides with Vectashield (Vector Laboratories, Amsterdam, the Netherlands).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "cells", "were", "stained", "with", "Hoechst", "33258", "(", "Molecular", "Probes", ",", "Invitrogen", ")", "for", "5", "min", ",", "washed", "with", "PBS", ",", "and", "coverslips", "were", "mounted", "on", "slides", "with", "Vectashield", "(", "Vector", "Laboratories", ",", "Amsterdam", ",", "the", "Netherlands", ")", "." ] } ]
PMC9429973
Results: Bioinformatic analyses of expression data suggested a role for LINC01547 in AML.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Bioinformatic", "analyses", "of", "expression", "data", "suggested", "a", "role", "for", "LINC01547", "in", "AML", "." ] } ]
PMC11261875
Thus, this transporter is essential in the modulation of cellular energy production .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "this", "transporter", "is", "essential", "in", "the", "modulation", "of", "cellular", "energy", "production", "." ] } ]
PMC11770130
In the current study, the depletion of one copy of CerS2 gene (referred as CerS2 mice, Fig. 3g; Supplementary information, Fig. S5a) led to a significant decrease in ceramide C24, trends of decreases in C20–C22, but without dramatic change in C16 in both eWATs and serum (Supplementary information, Fig. S5b, c and Tables S5, S6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "current", "study", ",", "the", "depletion", "of", "one", "copy", "of", "CerS2", "gene", "(", "referred", "as", "CerS2", "mice", ",", "Fig.", "3", "g", ";", "Supplementary", "information", ",", "Fig.", "S5a", ")", "led", "to", "a", "significant", "decrease", "in", "ceramide", "C24", ",", "trends", "of", "decreases", "in", "C20–C22", ",", "but", "without", "dramatic", "change", "in", "C16", "in", "both", "eWATs", "and", "serum", "(", "Supplementary", "information", ",", "Fig.", "S5b", ",", "c", "and", "Tables", "S5", ",", "S6", ")", "." ] } ]
PMC9429973
Adverse events (AEs) were graded per CTCAEv4, except for corneal AEs which were graded by the pre-specified keratopathy and visual acuity (KVA) scale.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adverse", "events", "(", "AEs", ")", "were", "graded", "per", "CTCAEv4", ",", "except", "for", "corneal", "AEs", "which", "were", "graded", "by", "the", "pre-specified", "keratopathy", "and", "visual", "acuity", "(", "KVA", ")", "scale", "." ] } ]
PMC9352806
Little known about whether these functional components could regulate FoxO1/TFEB mediated-lipophagy to maintain lipid homeostasis while inducing autophagy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Little", "known", "about", "whether", "these", "functional", "components", "could", "regulate", "FoxO1/TFEB", "mediated-lipophagy", "to", "maintain", "lipid", "homeostasis", "while", "inducing", "autophagy", "." ] } ]
PMC11514418
Besides, APS also increased the serum lymphokine levels of interleukin (IL)-2, IL-12, and Tumor necrosis factor α (TNF-α), but lowered the level of IL-10[8-10].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",", "APS", "also", "increased", "the", "serum", "lymphokine", "levels", "of", "interleukin", "(IL)-2", ",", "IL-12", ",", "and", "Tumor", "necrosis", "factor", "α", "(", "TNF-α", ")", ",", "but", "lowered", "the", "level", "of", "IL-10[8", "-", "10", "]", "." ] } ]
PMC6461034
The pTyr dataset contained in total 31 phosphoproteomics datasets, covering 16 different cell lines that could be linked to drug IC50 data, whereas the TiO2 cell line panel contained 20 different samples from 8 cell lines, linked to IC50 data.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "pTyr", "dataset", "contained", "in", "total", "31", "phosphoproteomics", "datasets", ",", "covering", "16", "different", "cell", "lines", "that", "could", "be", "linked", "to", "drug", "IC50", "data", ",", "whereas", "the", "TiO2", "cell", "line", "panel", "contained", "20", "different", "samples", "from", "8", "cell", "lines", ",", "linked", "to", "IC50", "data", "." ] } ]
PMC9429973
MRD flow cytometry was performed according to ERIC guidelines (panel: CD19/5/20/43/79/81+ROR1, acquisition of 0.5–2.2 million cells, BD Biosciences Lyric).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MRD", "flow", "cytometry", "was", "performed", "according", "to", "ERIC", "guidelines", "(", "panel", ":", "CD19/5/20/43/79/81+ROR1", ",", "acquisition", "of", "0.5–2.2", "million", "cells", ",", "BD", "Biosciences", "Lyric", ")", "." ] } ]
PMC11774112
Figure 4In vitro antitumor effect of Co-PHRD. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4In", "vitro", "antitumor", "effect", "of", "Co-PHRD", ".", "(" ] } ]
PMC9429973
Tisagenlecleucel is an autologous CD19-directed chimeric antigen receptor (CAR) T-cell therapy approved for use in pediatric and young adults with B-ALL and adults with B-cell lymphomas.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tisagenlecleucel", "is", "an", "autologous", "CD19-directed", "chimeric", "antigen", "receptor", "(", "CAR", ")", "T-cell", "therapy", "approved", "for", "use", "in", "pediatric", "and", "young", "adults", "with", "B-ALL", "and", "adults", "with", "B-cell", "lymphomas", "." ] } ]
PMC7351993
In the sorting experiment of stable isotope-labeled Euglena gracilis cells, the fluorescence signal from prestained nuclei was used as an indicator.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "sorting", "experiment", "of", "stable", "isotope-labeled", "Euglena", "gracilis", "cells", ",", "the", "fluorescence", "signal", "from", "prestained", "nuclei", "was", "used", "as", "an", "indicator", "." ] } ]
PMC9429973
Compared with healthy controls, patients with FL showed a lower CD4/CD8 ratio due to an increase in CD8 lymphocytes and a decrease in total CD4 lymphocytes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "with", "healthy", "controls", ",", "patients", "with", "FL", "showed", "a", "lower", "CD4/CD8", "ratio", "due", "to", "an", "increase", "in", "CD8", "lymphocytes", "and", "a", "decrease", "in", "total", "CD4", "lymphocytes", "." ] } ]
PMC11629461
C–K) Fura‐2 AM‐loaded CHO‐K1 (C, H), DUOX2‐CHO‐K1 cells (D–G, I–K) were perifused, UVA (380 nm, 3.5 mWatt/cm, 1.5 min) (C, E, G), VAS2870 (3 μM) (F, G), SALPC 2 μM (H, I, K), red LED (675 nm, 85 mWatt/cm, 1.5 min) (H, J, K) were applied as indicated by the horizontal bars.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "–", "K", ")", "Fura‐2", "AM‐loaded", "CHO‐K1", "(", "C", ",", "H", ")", ",", "DUOX2‐CHO‐K1", "cells", "(", "D", "–", "G", ",", "I", "–", "K", ")", "were", "perifused", ",", "UVA", "(", "380", "nm", ",", "3.5", "mWatt/cm", ",", "1.5", "min", ")", "(", "C", ",", "E", ",", "G", ")", ",", "VAS2870", "(", "3", "μM", ")", "(", "F", ",", "G", ")", ",", "SALPC", "2", "μM", "(", "H", ",", "I", ",", "K", ")", ",", "red", "LED", "(", "675", "nm", ",", "85", "mWatt/cm", ",", "1.5", "min", ")", "(", "H", ",", "J", ",", "K", ")", "were", "applied", "as", "indicated", "by", "the", "horizontal", "bars", "." ] } ]
PMC11126803
The results revealed that the ICI 182,780 can partly block/reverse the oe-LncRNA-SERB-increased ccRCC growth (Fig. 6B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "revealed", "that", "the", "ICI", "182,780", "can", "partly", "block/reverse", "the", "oe-LncRNA-SERB-increased", "ccRCC", "growth", "(", "Fig.", "6B", ")", "." ] } ]
PMC9429973
Analysis of the BCR-ABL1 transcript by both RQ-PCR and ddPCR methods in relation to the immune subpopulations showed significant differences between the percentage of HLA-DR+ cells and the depth of the molecular response: in RQ-PCR greater than or equal to MR4.0 at the moment of withdrawal vs loss of MR4.0 after 3 months (median 1.24 vs 1.87, p=0.03); greater than or equal to MR4.0 at the moment of withdrawal vs greater than or equal to MR4.0 after 3 months (median 1.24 vs 1.92, p<0.001).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "of", "the", "BCR-ABL1", "transcript", "by", "both", "RQ-PCR", "and", "ddPCR", "methods", "in", "relation", "to", "the", "immune", "subpopulations", "showed", "significant", "differences", "between", "the", "percentage", "of", "HLA-DR+", "cells", "and", "the", "depth", "of", "the", "molecular", "response", ":", "in", "RQ-PCR", "greater", "than", "or", "equal", "to", "MR4.0", "at", "the", "moment", "of", "withdrawal", "vs", "loss", "of", "MR4.0", "after", "3", "months", "(", "median", "1.24", "vs", "1.87", ",", "p=0.03", ")", ";", "greater", "than", "or", "equal", "to", "MR4.0", "at", "the", "moment", "of", "withdrawal", "vs", "greater", "than", "or", "equal", "to", "MR4.0", "after", "3", "months", "(", "median", "1.24", "vs", "1.92", ",", "p<0.001", ")", "." ] } ]
PMC8414691
Therefore, investigating the cellular functions of SRCAP may provide clues to the genetic and molecular basis of FHS onset.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "investigating", "the", "cellular", "functions", "of", "SRCAP", "may", "provide", "clues", "to", "the", "genetic", "and", "molecular", "basis", "of", "FHS", "onset", "." ] } ]
PMC6312945
BEL-7404 (STR is 5 ‘TTAGGG-3’) and MHCC97-L were both purchased from Shanghai Aolu Biotechnology Co., Ltd., Shanghai, China (cat nos. XFS3110, XFS3388, respectively) and proliferated in DEME medium (Shanghai Saily Biotechnology Co., Ltd., Shanghai, China) containing 15% fetal bovine serum.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BEL-7404", "(", "STR", "is", "5", "‘", "TTAGGG-3", "’", ")", "and", "MHCC97-L", "were", "both", "purchased", "from", "Shanghai", "Aolu", "Biotechnology", "Co.", ",", "Ltd.", ",", "Shanghai", ",", "China", "(", "cat", "nos.", "XFS3110", ",", "XFS3388", ",", "respectively", ")", "and", "proliferated", "in", "DEME", "medium", "(", "Shanghai", "Saily", "Biotechnology", "Co.", ",", "Ltd.", ",", "Shanghai", ",", "China", ")", "containing", "15", "%", "fetal", "bovine", "serum", "." ] } ]
PMC11240448
Our cSTAR model suggests that co-inhibition of mTOR and PKC can disrupt this vicious activation loop and normalize the phosphoproteomic patterns of the MDA-MB-468 cells, moving these closer to the patterns of normal breast tissue-derived cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "cSTAR", "model", "suggests", "that", "co-inhibition", "of", "mTOR", "and", "PKC", "can", "disrupt", "this", "vicious", "activation", "loop", "and", "normalize", "the", "phosphoproteomic", "patterns", "of", "the", "MDA-MB-468", "cells", ",", "moving", "these", "closer", "to", "the", "patterns", "of", "normal", "breast", "tissue-derived", "cells", "." ] } ]
PMC9429973
Tazemetostat (TAZ), an oral selective EZH2 inhibitor, is approved for treatment of relapsed or refractory (R/R) follicular lymphoma.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tazemetostat", "(", "TAZ", ")", ",", "an", "oral", "selective", "EZH2", "inhibitor", ",", "is", "approved", "for", "treatment", "of", "relapsed", "or", "refractory", "(", "R/R", ")", "follicular", "lymphoma", "." ] } ]
PMC10671321
COS cells were transfected at 80% confluence with 5 µg of each plasmid (AChE, Human ColQ1a WT-myc Tag, Human ColQ1a E428HfsX58-mycTag or Human ColQ ΔCt-mycTag) using fuGENE transfection reagent (Promega).
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "COS", "cells", "were", "transfected", "at", "80", "%", "confluence", "with", "5", "µg", "of", "each", "plasmid", "(", "AChE", ",", "Human", "ColQ1a", "WT-myc", "Tag", ",", "Human", "ColQ1a", "E428HfsX58-mycTag", "or", "Human", "ColQ", "ΔCt-mycTag", ")", "using", "fuGENE", "transfection", "reagent", "(", "Promega", ")", "." ] } ]
PMC11543885
Biotinylated proteins captured by NLRP3-APEX2 proximity labeling can be classified into i) proteins that physically bind to NLRP3 and or other components of the complex; ii) compartmental or proximal proteins in the local milieu of NLRP3; iii) proteins that non-specifically stick to streptavidin beads and iv) physically non-existing proteins detected as a methodological error.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Biotinylated", "proteins", "captured", "by", "NLRP3-APEX2", "proximity", "labeling", "can", "be", "classified", "into", "i", ")", "proteins", "that", "physically", "bind", "to", "NLRP3", "and", "or", "other", "components", "of", "the", "complex", ";", "ii", ")", "compartmental", "or", "proximal", "proteins", "in", "the", "local", "milieu", "of", "NLRP3", ";", "iii", ")", "proteins", "that", "non-specifically", "stick", "to", "streptavidin", "beads", "and", "iv", ")", "physically", "non-existing", "proteins", "detected", "as", "a", "methodological", "error", "." ] } ]
PMC10523483
Data derived from KMplot, automatic best cutoff was used to divide the cohort into high-H1.2 (n = 1,374) or low-H1.2 (n = 551) groups. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "derived", "from", "KMplot", ",", "automatic", "best", "cutoff", "was", "used", "to", "divide", "the", "cohort", "into", "high-H1.2", "(", "n", "=", "1,374", ")", "or", "low-H1.2", "(", "n", "=", "551", ")", "groups", ".", "(" ] } ]
PMC11271800
On the other hand, prolonged administration of imatinib polarizes intratumoral M2 TAMs and decreases expression of CD8 T cells, DCs, and MHC-I, thereby weakening the antitumor response.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "prolonged", "administration", "of", "imatinib", "polarizes", "intratumoral", "M2", "TAMs", "and", "decreases", "expression", "of", "CD8", "T", "cells", ",", "DCs", ",", "and", "MHC-I", ",", "thereby", "weakening", "the", "antitumor", "response", "." ] } ]
PMC11628309
The analysis of publications related to the BE (2)-M17 cell line indicates that FBS has predominantly been used, mostly at a concentration of 10%, with some variations between 5 and 20%.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "analysis", "of", "publications", "related", "to", "the", "BE", "(2)-M17", "cell", "line", "indicates", "that", "FBS", "has", "predominantly", "been", "used", ",", "mostly", "at", "a", "concentration", "of", "10", "%", ",", "with", "some", "variations", "between", "5", "and", "20", "%", "." ] } ]
PMC11711345
In fact, according to the predictions obtained with the CLC-Pred server, each compound in this study exhibited high cytotoxicity against A2780cisR cells (Pa ≥ 0.83).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "according", "to", "the", "predictions", "obtained", "with", "the", "CLC-Pred", "server", ",", "each", "compound", "in", "this", "study", "exhibited", "high", "cytotoxicity", "against", "A2780cisR", "cells", "(", "Pa", "≥", "0.83", ")", "." ] } ]
PMC11791478
Inhibition of tumor growth with XB002 in PDX models.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", "tumor", "growth", "with", "XB002", "in", "PDX", "models", "." ] } ]
PMC9429973
Aims: To study the clinical characteristics, outcomes, and survival of warm-type autoimmune hemolytic anemia (wAIHA) patients (pts).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "study", "the", "clinical", "characteristics", ",", "outcomes", ",", "and", "survival", "of", "warm-type", "autoimmune", "hemolytic", "anemia", "(", "wAIHA", ")", "patients", "(", "pts", ")", "." ] } ]
PMC11267830
This finding suggests that indisulam may exhibit better therapeutic effects on tumors arising from HL cell-derived tumors .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "finding", "suggests", "that", "indisulam", "may", "exhibit", "better", "therapeutic", "effects", "on", "tumors", "arising", "from", "HL", "cell-derived", "tumors", "." ] } ]
PMC11463018
Comparison of the mean GI50 values of compound 19 (black), ACY1215 (red), and SAHA (blue) against different tumour cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparison", "of", "the", "mean", "GI50", "values", "of", "compound", "19", "(", "black", ")", ",", "ACY1215", "(", "red", ")", ",", "and", "SAHA", "(", "blue", ")", "against", "different", "tumour", "cell", "lines", "." ] } ]
PMC11657695
The whiskers indicate the fifth and the ninety-fifth percentiles.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "whiskers", "indicate", "the", "fifth", "and", "the", "ninety-fifth", "percentiles", "." ] } ]
PMC11741906
To understand the probable functions of differentially expressed miRNAs in the development of cisplatin resistance in ovarian cancer cells, Gene Ontology enrichment analysis was performed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "understand", "the", "probable", "functions", "of", "differentially", "expressed", "miRNAs", "in", "the", "development", "of", "cisplatin", "resistance", "in", "ovarian", "cancer", "cells", ",", "Gene", "Ontology", "enrichment", "analysis", "was", "performed", "." ] } ]
PMC7987994
If there are more pieces of the material, it is also reasonable to extract those pieces in separated vessels to prevent abrasion, which is another factor not specified in the ISO standard.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "If", "there", "are", "more", "pieces", "of", "the", "material", ",", "it", "is", "also", "reasonable", "to", "extract", "those", "pieces", "in", "separated", "vessels", "to", "prevent", "abrasion", ",", "which", "is", "another", "factor", "not", "specified", "in", "the", "ISO", "standard", "." ] } ]
PMC11566417
At p20, however, primary MDECs trended towards a larger and less uniform morphology compared to immortalized MDECs (Fig. 1c).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "p20", ",", "however", ",", "primary", "MDECs", "trended", "towards", "a", "larger", "and", "less", "uniform", "morphology", "compared", "to", "immortalized", "MDECs", "(", "Fig.", "1c", ")", "." ] } ]
PMC11434983
Cultures without treatment were also included as controls.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cultures", "without", "treatment", "were", "also", "included", "as", "controls", "." ] } ]
PMC8557138
Though in vivo models compensate the shortcomings of the in vitro models such as 3D architecture, better physiological replica, and influence of diverse systemic factors, they still fail to faithfully replicate the parent tissue due to reproducibility, biokinetic parameters, intraspecific variations, and structural and functional dissimilarity between the parental and the experimental tissue.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Though", "in", "vivo", "models", "compensate", "the", "shortcomings", "of", "the", "in", "vitro", "models", "such", "as", "3D", "architecture", ",", "better", "physiological", "replica", ",", "and", "influence", "of", "diverse", "systemic", "factors", ",", "they", "still", "fail", "to", "faithfully", "replicate", "the", "parent", "tissue", "due", "to", "reproducibility", ",", "biokinetic", "parameters", ",", "intraspecific", "variations", ",", "and", "structural", "and", "functional", "dissimilarity", "between", "the", "parental", "and", "the", "experimental", "tissue", "." ] } ]
PMC9856122
Noscapine is also found to be responsible for showing inhibitory action against cytokine storm in COVID-19 .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Noscapine", "is", "also", "found", "to", "be", "responsible", "for", "showing", "inhibitory", "action", "against", "cytokine", "storm", "in", "COVID-19", "." ] } ]
PMC11549062
We have generated two independent Rab5 shRNA expressing cos7 lines, and the substantial disruption of endocytosis particles' movement was observed (Figure 3A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "generated", "two", "independent", "Rab5", "shRNA", "expressing", "cos7", "lines", ",", "and", "the", "substantial", "disruption", "of", "endocytosis", "particles", "'", "movement", "was", "observed", "(", "Figure", "3A", ")", "." ] } ]
PMC11200978
In addition to use as a first- and second-line treatment of lung adenocarcinoma, gemcitabine is also used as an adjuvant either before or after surgery, or in combination with other treatments (immunotherapy, thermal ablation) for patients who are not good surgical candidates .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "use", "as", "a", "first-", "and", "second-line", "treatment", "of", "lung", "adenocarcinoma", ",", "gemcitabine", "is", "also", "used", "as", "an", "adjuvant", "either", "before", "or", "after", "surgery", ",", "or", "in", "combination", "with", "other", "treatments", "(", "immunotherapy", ",", "thermal", "ablation", ")", "for", "patients", "who", "are", "not", "good", "surgical", "candidates", "." ] } ]
PMC11089031
In vitro cells experiment shown that ZNF692 promoted the proliferation and migration of ccRCC cells (Fig. 3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vitro", "cells", "experiment", "shown", "that", "ZNF692", "promoted", "the", "proliferation", "and", "migration", "of", "ccRCC", "cells", "(", "Fig.", "3", ")", "." ] } ]
PMC11604830
PEG polymer is characterized by a sharp H NMR signal located ca.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PEG", "polymer", "is", "characterized", "by", "a", "sharp", "H", "NMR", "signal", "located", "ca", "." ] } ]
PMC9429973
Finally, we identified a consistent sEV gene signatures in CLL patients correlating with treatment-free survival, overall survival, and with unfavorable clinical parameters routinely used in CLL diagnosis and prognosis (D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "we", "identified", "a", "consistent", "sEV", "gene", "signatures", "in", "CLL", "patients", "correlating", "with", "treatment-free", "survival", ",", "overall", "survival", ",", "and", "with", "unfavorable", "clinical", "parameters", "routinely", "used", "in", "CLL", "diagnosis", "and", "prognosis", "(", "D", ")", "." ] } ]
PMC10748106
From the Pearson correlation matrix, we corroborated that the molecular descriptors are not linearly correlated (Table S1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "the", "Pearson", "correlation", "matrix", ",", "we", "corroborated", "that", "the", "molecular", "descriptors", "are", "not", "linearly", "correlated", "(", "Table", "S1", ")", "." ] } ]
PMC11422150
The findings support further investigation of the hAMSC as a potential treatment for SCI, focusing on their ability to modulate inflammation and promote neuroprotection.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "findings", "support", "further", "investigation", "of", "the", "hAMSC", "as", "a", "potential", "treatment", "for", "SCI", ",", "focusing", "on", "their", "ability", "to", "modulate", "inflammation", "and", "promote", "neuroprotection", "." ] } ]
PMC9429973
Logistic regression and Cox survival analysis were used for developing the evaluation model of SCTC-DI risk and prediction model for new-onset organ damage respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Logistic", "regression", "and", "Cox", "survival", "analysis", "were", "used", "for", "developing", "the", "evaluation", "model", "of", "SCTC-DI", "risk", "and", "prediction", "model", "for", "new-onset", "organ", "damage", "respectively", "." ] } ]
PMC9429973
Serological testing included an antibody screen using gel technology, a direct antiglobulin test (DAT) using immunoglobulin G and C3d, and a Sterility testing of the transfused platelet product.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serological", "testing", "included", "an", "antibody", "screen", "using", "gel", "technology", ",", "a", "direct", "antiglobulin", "test", "(", "DAT", ")", "using", "immunoglobulin", "G", "and", "C3d", ",", "and", "a", "Sterility", "testing", "of", "the", "transfused", "platelet", "product", "." ] } ]
PMC11422497
To eliminate any remaining cells that had not migrated, a cotton swab was utilized.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "eliminate", "any", "remaining", "cells", "that", "had", "not", "migrated", ",", "a", "cotton", "swab", "was", "utilized", "." ] } ]
PMC7334607
In this work, we aimed to examine collateral sensitivity and resistance across time during development of therapeutic resistance to EWS standard of care.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "work", ",", "we", "aimed", "to", "examine", "collateral", "sensitivity", "and", "resistance", "across", "time", "during", "development", "of", "therapeutic", "resistance", "to", "EWS", "standard", "of", "care", "." ] } ]
PMC7039683
To compare our zebrafish periderm ATAC-seq results to those in previously published whole-embryo H3K27Ac ChIP-seq studies (Bogdanovic et al., 2012), we retrieved the single-end, raw read data from GEO Series GSE32483 H3K27Ac ChIP-seq from whole zebrafish embryos at several stages.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "compare", "our", "zebrafish", "periderm", "ATAC-seq", "results", "to", "those", "in", "previously", "published", "whole-embryo", "H3K27Ac", "ChIP-seq", "studies", "(", "Bogdanovic", "et", "al.", ",", "2012", ")", ",", "we", "retrieved", "the", "single-end", ",", "raw", "read", "data", "from", "GEO", "Series", "GSE32483", "H3K27Ac", "ChIP-seq", "from", "whole", "zebrafish", "embryos", "at", "several", "stages", "." ] } ]
PMC11277157
Next-generation sequencing data underwent quality control using FastQC, version 0.11.9.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next-generation", "sequencing", "data", "underwent", "quality", "control", "using", "FastQC", ",", "version", "0.11.9", "." ] } ]
PMC11794588
The HPLC column was in the reverse phase.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "HPLC", "column", "was", "in", "the", "reverse", "phase", "." ] } ]
PMC5874706
This phenomenon can be explained by several mechanisms.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "phenomenon", "can", "be", "explained", "by", "several", "mechanisms", "." ] } ]
PMC9429973
Results: We analyzed 82 patients with a median age at the moment of transplant of 55 (R 22-73) years.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "analyzed", "82", "patients", "with", "a", "median", "age", "at", "the", "moment", "of", "transplant", "of", "55", "(", "R", "22", "-", "73", ")", "years", "." ] } ]