OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11394730	Quercetin is a dietary flavonoid that is commonly found in fruits and vegetables and is consumed in copious quantities in Western diets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quercetin", "is", "a", "dietary", "flavonoid", "that", "is", "commonly", "found", "in", "fruits", "and", "vegetables", "and", "is", "consumed", "in", "copious", "quantities", "in", "Western", "diets", "." ] } ]
PMC11323699	Eight-week-old C57BL/6 J mice were IP injected with 2 × 10 ID8 Trp53 Brca2 cells in 300 µL HBSS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight-week-old", "C57BL/6", "J", "mice", "were", "IP", "injected", "with", "2", "×", "10", "ID8", "Trp53", "Brca2", "cells", "in", "300", "µL", "HBSS", "." ] } ]
PMC9429973	Patients with decreased or no change in Hb levels after 6 months of RAV experienced more inpatient visits (mean visits [SD]: 1.3 [2.0]) compared to patients with increased Hb levels (mean visits [SD]: 0.9 [1.5]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "with", "decreased", "or", "no", "change", "in", "Hb", "levels", "after", "6", "months", "of", "RAV", "experienced", "more", "inpatient", "visits", "(", "mean", "visits", "[", "SD", "]", ":", "1.3", "[", "2.0", "]", ")", "compared", "to", "patients", "with", "increased", "Hb", "levels", "(", "mean", "visits", "[", "SD", "]", ":", "0.9", "[", "1.5", "]", ")", "." ] } ]
PMC11591038	HIF-1 is involved in the differentiation, migration, metabolism, and survival of dendrite cells under hypoxia and inflammation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HIF-1", "is", "involved", "in", "the", "differentiation", ",", "migration", ",", "metabolism", ",", "and", "survival", "of", "dendrite", "cells", "under", "hypoxia", "and", "inflammation", "." ] } ]
PMC10452486	Not only was a 43 kDa HC precipitated without B2m by A1.4, but a novel 38 kDa molecule was as well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Not", "only", "was", "a", "43", "kDa", "HC", "precipitated", "without", "B2", "m", "by", "A1.4", ",", "but", "a", "novel", "38", "kDa", "molecule", "was", "as", "well", "." ] } ]
PMC11095939	Lower panel: quantification of the percentage of 3T3 cells in the G0 phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower", "panel", ":", "quantification", "of", "the", "percentage", "of", "3T3", "cells", "in", "the", "G0", "phase", "." ] } ]
PMC11803918	Percentages of CD86 cells in CD11c dendritic cells and CD11b macrophages in the peripheral blood from humanized mice with different treatments. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Percentages", "of", "CD86", "cells", "in", "CD11c", "dendritic", "cells", "and", "CD11b", "macrophages", "in", "the", "peripheral", "blood", "from", "humanized", "mice", "with", "different", "treatments", ".", "(" ] } ]
PMC11746948	It has been observed that cancer cells transitioning into therapy-resistant states rely on GPX4, identifying it as a potential target in cancer therapy strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "observed", "that", "cancer", "cells", "transitioning", "into", "therapy-resistant", "states", "rely", "on", "GPX4", ",", "identifying", "it", "as", "a", "potential", "target", "in", "cancer", "therapy", "strategies", "." ] } ]
PMC10222971	Results of the ten naphthoquinones selected from the wheat coleoptile bioassay were assayed on HeLa cells for 24 h. are illustrated in Figure 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "of", "the", "ten", "naphthoquinones", "selected", "from", "the", "wheat", "coleoptile", "bioassay", "were", "assayed", "on", "HeLa", "cells", "for", "24", "h.", "are", "illustrated", "in", "Figure", "3", "." ] } ]
PMC9429973	The median follow-up time was 9.7 (1.2 – 19.2) months for the TN cohort and 3.8 (0.3 – 9.6) months for the R/R cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "follow-up", "time", "was", "9.7", "(", "1.2", "–", "19.2", ")", "months", "for", "the", "TN", "cohort", "and", "3.8", "(", "0.3", "–", "9.6", ")", "months", "for", "the", "R/R", "cohort", "." ] } ]
PMC11591030	As shown in Figure 3, under non-stress conditions, supplementation with various concentrations of AOP significantly enhanced the expression of the CAT gene compared to the control group, with no significant difference compared to the VA treatment group (p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Figure", "3", ",", "under", "non-stress", "conditions", ",", "supplementation", "with", "various", "concentrations", "of", "AOP", "significantly", "enhanced", "the", "expression", "of", "the", "CAT", "gene", "compared", "to", "the", "control", "group", ",", "with", "no", "significant", "difference", "compared", "to", "the", "VA", "treatment", "group", "(", "p", "<", "0.05", ")", "." ] } ]
PMC11395280	The data were normalized to the maximum Ca released in the presence of ionomycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "were", "normalized", "to", "the", "maximum", "Ca", "released", "in", "the", "presence", "of", "ionomycin", "." ] } ]
PMC11718031	Feed is added at certain time intervals to maximize the volumetric productivity and product titer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Feed", "is", "added", "at", "certain", "time", "intervals", "to", "maximize", "the", "volumetric", "productivity", "and", "product", "titer", "." ] } ]
PMC10165258	The response of spheroids of Ewing sarcoma (EwS) A673 cells to simultaneous or sequential combinations of etoposide and cisplatin was evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "response", "of", "spheroids", "of", "Ewing", "sarcoma", "(", "EwS", ")", "A673", "cells", "to", "simultaneous", "or", "sequential", "combinations", "of", "etoposide", "and", "cisplatin", "was", "evaluated", "." ] } ]
PMC11725127	Interestingly, preincubation of iodoacetic acid (IAA), a cysteine alkylating agent, with USP2 completely inhibited the binding of biotin-GA to USP2 (Supporting Information Fig. S8), suggesting that GA may covalently bind to the cysteine(s) of USP2, which is consistent with previous reports that GA can covalently bind to its targets through cysteine residues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "preincubation", "of", "iodoacetic", "acid", "(", "IAA", ")", ",", "a", "cysteine", "alkylating", "agent", ",", "with", "USP2", "completely", "inhibited", "the", "binding", "of", "biotin-GA", "to", "USP2", "(", "Supporting", "Information", "Fig.", "S8", ")", ",", "suggesting", "that", "GA", "may", "covalently", "bind", "to", "the", "cysteine(s", ")", "of", "USP2", ",", "which", "is", "consistent", "with", "previous", "reports", "that", "GA", "can", "covalently", "bind", "to", "its", "targets", "through", "cysteine", "residues", "." ] } ]
PMC11435360	Furthermore, we investigated the effects of PAG in combination with GEM chemotherapy, a clinically used intravesical therapeutic agent for BC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "investigated", "the", "effects", "of", "PAG", "in", "combination", "with", "GEM", "chemotherapy", ",", "a", "clinically", "used", "intravesical", "therapeutic", "agent", "for", "BC", "." ] } ]
PMC9429973	Results: 3D co-cultures of h- or AML-MSCs and AML blasts or HSCs showed that AML-MSCs strongly supported AML cells proliferation (by Ki67), but decreased normal HSCs proliferation (reduction of 32%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "3D", "co-cultures", "of", "h-", "or", "AML-MSCs", "and", "AML", "blasts", "or", "HSCs", "showed", "that", "AML-MSCs", "strongly", "supported", "AML", "cells", "proliferation", "(", "by", "Ki67", ")", ",", "but", "decreased", "normal", "HSCs", "proliferation", "(", "reduction", "of", "32", "%", ")", "." ] } ]
PMC11206251	After washing, the membranes were further incubated with secondary antibodies at room temperature for 1 h. Finally, the protein bands were visualized using an Omni-ECLTM ultrasensitive chemiluminescence detection kit (Epizyme, Shanghai, China) by an imaging system (Bio-Rad, Hercules, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "washing", ",", "the", "membranes", "were", "further", "incubated", "with", "secondary", "antibodies", "at", "room", "temperature", "for", "1", "h.", "Finally", ",", "the", "protein", "bands", "were", "visualized", "using", "an", "Omni-ECLTM", "ultrasensitive", "chemiluminescence", "detection", "kit", "(", "Epizyme", ",", "Shanghai", ",", "China", ")", "by", "an", "imaging", "system", "(", "Bio-Rad", ",", "Hercules", ",", "CA", ",", "USA", ")", "." ] } ]
PMC9681981	A P-value less than 0.05 was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "P-value", "less", "than", "0.05", "was", "considered", "statistically", "significant", "." ] } ]
PMC10747139	Moreover, the modulation activity of amyloid-β aggregation has been described, which can be useful in the treatment of Alzheimer’s disease .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "modulation", "activity", "of", "amyloid-β", "aggregation", "has", "been", "described", ",", "which", "can", "be", "useful", "in", "the", "treatment", "of", "Alzheimer", "’s", "disease", "." ] } ]
PMC10523483	Representative IHC images of 8-OHdG staining in K and KH lung tumors. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "IHC", "images", "of", "8-OHdG", "staining", "in", "K", "and", "KH", "lung", "tumors", ".", "(" ] } ]
PMC11513011	Antitumor effects on 5637 need to be investigated further.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antitumor", "effects", "on", "5637", "need", "to", "be", "investigated", "further", "." ] } ]
PMC11798926	Cultures were then fixed with 4% PFA and 4% sucrose in PBS for 10 min at RT, followed by three washes in RT PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cultures", "were", "then", "fixed", "with", "4", "%", "PFA", "and", "4", "%", "sucrose", "in", "PBS", "for", "10", "min", "at", "RT", ",", "followed", "by", "three", "washes", "in", "RT", "PBS", "." ] } ]
PMC8956657	Anti-rabbit and anti-mouse IgG, HRP-linked antibodies were purchased from Cell Signaling (cat# 7074 and 7076).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-rabbit", "and", "anti-mouse", "IgG", ",", "HRP-linked", "antibodies", "were", "purchased", "from", "Cell", "Signaling", "(", "cat", "#", "7074", "and", "7076", ")", "." ] } ]
PMC11721277	The lipophilic radiometabolites of the HYNIC-chlorin complex can quickly leak through the cell membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lipophilic", "radiometabolites", "of", "the", "HYNIC-chlorin", "complex", "can", "quickly", "leak", "through", "the", "cell", "membrane", "." ] } ]
PMC11585565	The relative expression levels of WT and mutant CNNM4 mRNAs showed no significant difference at 24-hours post-transfection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "expression", "levels", "of", "WT", "and", "mutant", "CNNM4", "mRNAs", "showed", "no", "significant", "difference", "at", "24-hours", "post-transfection", "." ] } ]
PMC11190538	This could verify the protein nature of the extracted C-PC.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "could", "verify", "the", "protein", "nature", "of", "the", "extracted", "C-PC.Fig", "." ] } ]
PMC10094992	The expected minimum detectable concentration of IL-8 for this set is 8 pg/mL. Human neutrophils were collected and isolated from venous blood samples from healthy volunteers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expected", "minimum", "detectable", "concentration", "of", "IL-8", "for", "this", "set", "is", "8", "pg/mL.", "Human", "neutrophils", "were", "collected", "and", "isolated", "from", "venous", "blood", "samples", "from", "healthy", "volunteers", "." ] } ]
PMC9429973	Secondary end point was objective response rate (ORR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "end", "point", "was", "objective", "response", "rate", "(", "ORR", ")", "." ] } ]
PMC7685376	We also analyzed candidate expression after Huaier treatment in HCC cells by WB and qRT-PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "analyzed", "candidate", "expression", "after", "Huaier", "treatment", "in", "HCC", "cells", "by", "WB", "and", "qRT-PCR", "." ] } ]
PMC9429973	During the study follow-up (median 101 days; range 21-222) 84 patients deceased after a median time of 14 days (IQR: 8-49, range 0-457) since COVID-19 diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "the", "study", "follow-up", "(", "median", "101", "days", ";", "range", "21", "-", "222", ")", "84", "patients", "deceased", "after", "a", "median", "time", "of", "14", "days", "(", "IQR", ":", "8", "-", "49", ",", "range", "0", "-", "457", ")", "since", "COVID-19", "diagnosis", "." ] } ]
PMC8143558	ex Oliv in South Africa ; Helinus integrifolia (Lam) Kuntze in South Africa and Senna obtusifolia L. in South Africa .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ex", "Oliv", "in", "South", "Africa", ";", "Helinus", "integrifolia", "(", "Lam", ")", "Kuntze", "in", "South", "Africa", "and", "Senna", "obtusifolia", "L.", "in", "South", "Africa", "." ] } ]
PMC8633974	Added value of this studyCRISPR-Cas9 gRNAs designed against multiclade HIV-1 consensus sequences were proven effective against a broad range of viral strains.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Added", "value", "of", "this", "studyCRISPR-Cas9", "gRNAs", "designed", "against", "multiclade", "HIV-1", "consensus", "sequences", "were", "proven", "effective", "against", "a", "broad", "range", "of", "viral", "strains", "." ] } ]
PMC11721064	2Molecular phenotype characterization of LNCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "2Molecular", "phenotype", "characterization", "of", "LNCs", "." ] } ]
PMC11257203	Subsequently, the plates were incubated for 20 h under the conditions of 5% CO2 air at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "plates", "were", "incubated", "for", "20", "h", "under", "the", "conditions", "of", "5", "%", "CO2", "air", "at", "37", "°", "C", "." ] } ]
PMC11013014	Despite significant advancements in therapeutic interventions, drug resistance and adverse side effects remain arduous obstacles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "significant", "advancements", "in", "therapeutic", "interventions", ",", "drug", "resistance", "and", "adverse", "side", "effects", "remain", "arduous", "obstacles", "." ] } ]
PMC10582049	Grout et al. identified that ADH1B CAFs had a high expression of IL34, CSF1, CCL19, CCL21, and CXCL12.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grout", "et", "al.", "identified", "that", "ADH1B", "CAFs", "had", "a", "high", "expression", "of", "IL34", ",", "CSF1", ",", "CCL19", ",", "CCL21", ",", "and", "CXCL12", "." ] } ]
PMC11248911	The screening of the molecules was completed using PyRx 0.8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "screening", "of", "the", "molecules", "was", "completed", "using", "PyRx", "0.8", "." ] } ]
PMC11544122	a Agonist stimulated endocytosis of CXCR4, β2AR, and AT1AR was examined in HEK293 cells transfected with control siRNA (siCon) or two combinations of siRNA against SNX9 and SNX18.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Agonist", "stimulated", "endocytosis", "of", "CXCR4", ",", "β2AR", ",", "and", "AT1AR", "was", "examined", "in", "HEK293", "cells", "transfected", "with", "control", "siRNA", "(", "siCon", ")", "or", "two", "combinations", "of", "siRNA", "against", "SNX9", "and", "SNX18", "." ] } ]
PMC10728200	Yet, there is limited research on ferroptosis in GIST, and the underlying mechanism remains unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yet", ",", "there", "is", "limited", "research", "on", "ferroptosis", "in", "GIST", ",", "and", "the", "underlying", "mechanism", "remains", "unclear", "." ] } ]
PMC11359735	C, a representative extracted ion chromatogram (EIC) of the CSP-3 sample, where m/z 305 and m/z 318 represent the native H6-myo-inositol of the CSP-3 sample and m/z 307 and 321 represent the D6-myo-inositol internal standard.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ",", "a", "representative", "extracted", "ion", "chromatogram", "(", "EIC", ")", "of", "the", "CSP-3", "sample", ",", "where", "m/z", "305", "and", "m/z", "318", "represent", "the", "native", "H6-myo-inositol", "of", "the", "CSP-3", "sample", "and", "m/z", "307", "and", "321", "represent", "the", "D6-myo-inositol", "internal", "standard", "." ] } ]
PMC11752740	SK-BR3 and MCF10A cells were plated at a density of 2.5 × 10 cells per well in a 6-well plate, using 200 µl of complete medium.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SK-BR3", "and", "MCF10A", "cells", "were", "plated", "at", "a", "density", "of", "2.5", "×", "10", "cells", "per", "well", "in", "a", "6-well", "plate", ",", "using", "200", "µl", "of", "complete", "medium", "." ] } ]
PMC11782508	EDX analysis. (	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "EDX", "analysis", ".", "(" ] } ]
PMC9532503	ADCC is the most important mechanism of action for the efficacy of these antibodies in B cell lymphoma patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ADCC", "is", "the", "most", "important", "mechanism", "of", "action", "for", "the", "efficacy", "of", "these", "antibodies", "in", "B", "cell", "lymphoma", "patients", "." ] } ]
PMC11762280	Therefore, our study further confirmed the complexity of keratinocyte RCDs after UVB irradiation, including GSDME-mediated pyroptosis , ferroptosis , and PANoptosis, among which PANoptosis is the key lethal modality leading to keratinocyte death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "our", "study", "further", "confirmed", "the", "complexity", "of", "keratinocyte", "RCDs", "after", "UVB", "irradiation", ",", "including", "GSDME-mediated", "pyroptosis", ",", "ferroptosis", ",", "and", "PANoptosis", ",", "among", "which", "PANoptosis", "is", "the", "key", "lethal", "modality", "leading", "to", "keratinocyte", "death", "." ] } ]
PMC9884169	AMPK is responsible for controlling and regulating the energy supply system of cells, which at the same time responds to the environment, improving the adaptability of cells themselves .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AMPK", "is", "responsible", "for", "controlling", "and", "regulating", "the", "energy", "supply", "system", "of", "cells", ",", "which", "at", "the", "same", "time", "responds", "to", "the", "environment", ",", "improving", "the", "adaptability", "of", "cells", "themselves", "." ] } ]
PMC9429973	Data on comorbidities, baseline laboratory parameters, and indication for performing a bone marrow culture were extracted from the institution’s electronic medical records system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "on", "comorbidities", ",", "baseline", "laboratory", "parameters", ",", "and", "indication", "for", "performing", "a", "bone", "marrow", "culture", "were", "extracted", "from", "the", "institution", "’s", "electronic", "medical", "records", "system", "." ] } ]
PMC11585587	The results of CCK-8 showed that RA inhibited the proliferation of MM cells, including MM.1 S, MM1R, and RPMI 8226 cells, in a time-dependent and concentration-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "of", "CCK-8", "showed", "that", "RA", "inhibited", "the", "proliferation", "of", "MM", "cells", ",", "including", "MM.1", "S", ",", "MM1R", ",", "and", "RPMI", "8226", "cells", ",", "in", "a", "time-dependent", "and", "concentration-dependent", "manner", "." ] } ]
PMC11767725	Significant improvements in HS severity were observed, with Hurley stage scores decreasing from 2.6 ± 0.5 to 1.1 ± 0.3 (p = 0.002), and Dermatology Life Quality Index (DLQI) scores improving from 12.3 ± 2.8 to 9.7 ± 6.9 (p = 0.04).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significant", "improvements", "in", "HS", "severity", "were", "observed", ",", "with", "Hurley", "stage", "scores", "decreasing", "from", "2.6", "±", "0.5", "to", "1.1", "±", "0.3", "(", "p", "=", "0.002", ")", ",", "and", "Dermatology", "Life", "Quality", "Index", "(", "DLQI", ")", "scores", "improving", "from", "12.3", "±", "2.8", "to", "9.7", "±", "6.9", "(", "p", "=", "0.04", ")", "." ] } ]
PMC11575040	The Venn diagram illustrates that 41 upregulated lncRNAs and 14 downregulated lncRNAs were concurrently identified in two melanoma cell lines (A2058 and A375) following metformin treatment (Fig. 1A).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Venn", "diagram", "illustrates", "that", "41", "upregulated", "lncRNAs", "and", "14", "downregulated", "lncRNAs", "were", "concurrently", "identified", "in", "two", "melanoma", "cell", "lines", "(", "A2058", "and", "A375", ")", "following", "metformin", "treatment", "(", "Fig.", "1A).Fig", "." ] } ]
PMC10218459	To analyze the underlying mechanism of cell death, the apoptosis detection methods TUNEL and caspase 3/7 activation assay were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "analyze", "the", "underlying", "mechanism", "of", "cell", "death", ",", "the", "apoptosis", "detection", "methods", "TUNEL", "and", "caspase", "3/7", "activation", "assay", "were", "used", "." ] } ]
PMC9429973	The differential diagnostic was continued among hemolytic-uremic syndrome, TTP, cancer, autoimmune disorder and viral infections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "differential", "diagnostic", "was", "continued", "among", "hemolytic-uremic", "syndrome", ",", "TTP", ",", "cancer", ",", "autoimmune", "disorder", "and", "viral", "infections", "." ] } ]
PMC11789597	viSNE analysis was used to visualize these high‐dimensional mass cytometry data in 2D, and seven T or NK cell subsets were identified (Figure 3C–E; Figure S4A, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "viSNE", "analysis", "was", "used", "to", "visualize", "these", "high‐dimensional", "mass", "cytometry", "data", "in", "2D", ",", "and", "seven", "T", "or", "NK", "cell", "subsets", "were", "identified", "(", "Figure", "3C", "–", "E", ";", "Figure", "S4A", ",", "Supporting", "Information", ")", "." ] } ]
PMC11092382	Therefore, sophocarpine may be used as a potential reagent for treating prosthesis loosening (Zhou et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "sophocarpine", "may", "be", "used", "as", "a", "potential", "reagent", "for", "treating", "prosthesis", "loosening", "(", "Zhou", "et", "al.", ",", "2018", ")", "." ] } ]
PMC11721295	CAFs support tumor growth through paracrine signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAFs", "support", "tumor", "growth", "through", "paracrine", "signaling", "." ] } ]
PMC11775197	↓ indicates inhibition and ↑ indicates increase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "↓", "indicates", "inhibition", "and", "↑", "indicates", "increase", "." ] } ]
PMC11763126	A IP combined with mass spectrometry revealed that usp5 binds to YTHDF2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "IP", "combined", "with", "mass", "spectrometry", "revealed", "that", "usp5", "binds", "to", "YTHDF2", "." ] } ]
PMC9436459	Kuwanon H (93), multicaulisin (99), and sanggenon G (124) were found to possess potent effect against ten clinical MRSA strains with MICs/MBCs of 2–8/16–128 mg/L, and also showed synergy with conventional antibacterial agents such as aminoglycosides .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kuwanon", "H", "(", "93", ")", ",", "multicaulisin", "(", "99", ")", ",", "and", "sanggenon", "G", "(", "124", ")", "were", "found", "to", "possess", "potent", "effect", "against", "ten", "clinical", "MRSA", "strains", "with", "MICs/MBCs", "of", "2–8/16–128", "mg/L", ",", "and", "also", "showed", "synergy", "with", "conventional", "antibacterial", "agents", "such", "as", "aminoglycosides", "." ] } ]
PMC8584319	Furthermore, refametinib pre-treatment before AZD8055 exposure led to a dose-dependent synergistic effect on translational inhibition (Figure 4a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "refametinib", "pre-treatment", "before", "AZD8055", "exposure", "led", "to", "a", "dose-dependent", "synergistic", "effect", "on", "translational", "inhibition", "(", "Figure", "4a", ")", "." ] } ]
PMC11473843	All data presented are expressed as mean ± SD (unless indicated in the figure legends) of 3 or more biologically independent replicates/group (the specific number is indicated in the related figure legends).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "presented", "are", "expressed", "as", "mean", "±", "SD", "(", "unless", "indicated", "in", "the", "figure", "legends", ")", "of", "3", "or", "more", "biologically", "independent", "replicates/group", "(", "the", "specific", "number", "is", "indicated", "in", "the", "related", "figure", "legends", ")", "." ] } ]
PMC11474209	Cyanotoxins are produced by cyanobacteria found in lakes and oceans, and they can rapidly reproduce in high phosphorus concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cyanotoxins", "are", "produced", "by", "cyanobacteria", "found", "in", "lakes", "and", "oceans", ",", "and", "they", "can", "rapidly", "reproduce", "in", "high", "phosphorus", "concentrations", "." ] } ]
PMC9429973	Image: Summary/Conclusion: NFκB is an exciting target but challenging drug target due to its heterogenous activity in DLBCL cases and importance in normal cellular functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "NFκB", "is", "an", "exciting", "target", "but", "challenging", "drug", "target", "due", "to", "its", "heterogenous", "activity", "in", "DLBCL", "cases", "and", "importance", "in", "normal", "cellular", "functions", "." ] } ]
PMC9429973	It is widely accepted that a sustained deep molecular remission (DMR) is the pre-requisite to discontinue TKI, and it is expected that in patients who start treatment with imatinib (IMA) and fail early molecular remission (EMR), a switch to a second generation TKI may improve the probability of achieving a DMR Aims: We launched in November 2016 an international, prospective, interventional, randomized, two arms, study to evaluate both the depth of the molecular response and the rate of TFR in newly diagnosed CP-CML patients treated with a second generation TKI (Nilotinib, NIL) or with IMA followed by switching to NIL in absence of optimal response (defined according the ELN 2013 criteria (Clinical Trial number 02602314).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "widely", "accepted", "that", "a", "sustained", "deep", "molecular", "remission", "(", "DMR", ")", "is", "the", "pre-requisite", "to", "discontinue", "TKI", ",", "and", "it", "is", "expected", "that", "in", "patients", "who", "start", "treatment", "with", "imatinib", "(", "IMA", ")", "and", "fail", "early", "molecular", "remission", "(", "EMR", ")", ",", "a", "switch", "to", "a", "second", "generation", "TKI", "may", "improve", "the", "probability", "of", "achieving", "a", "DMR", "Aims", ":", "We", "launched", "in", "November", "2016", "an", "international", ",", "prospective", ",", "interventional", ",", "randomized", ",", "two", "arms", ",", "study", "to", "evaluate", "both", "the", "depth", "of", "the", "molecular", "response", "and", "the", "rate", "of", "TFR", "in", "newly", "diagnosed", "CP-CML", "patients", "treated", "with", "a", "second", "generation", "TKI", "(", "Nilotinib", ",", "NIL", ")", "or", "with", "IMA", "followed", "by", "switching", "to", "NIL", "in", "absence", "of", "optimal", "response", "(", "defined", "according", "the", "ELN", "2013", "criteria", "(", "Clinical", "Trial", "number", "02602314", ")", "." ] } ]
PMC11779605	Purple indicates genes that are downregulated in the tumor compared to those in the ascites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Purple", "indicates", "genes", "that", "are", "downregulated", "in", "the", "tumor", "compared", "to", "those", "in", "the", "ascites", "." ] } ]
PMC9429973	Second, co-culture with LN-derived stromal cells further increased CLL proliferation, reaching a maximum of 8 generations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Second", ",", "co-culture", "with", "LN-derived", "stromal", "cells", "further", "increased", "CLL", "proliferation", ",", "reaching", "a", "maximum", "of", "8", "generations", "." ] } ]
PMC11411004	The level of gene transcription is correlated with the histone acetylation status of the promoter (Shvedunova and Akhtar 2022), which induces gene expression by remodeling the chromatin structure (Salminen et al. 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "level", "of", "gene", "transcription", "is", "correlated", "with", "the", "histone", "acetylation", "status", "of", "the", "promoter", "(", "Shvedunova", "and", "Akhtar", "2022", ")", ",", "which", "induces", "gene", "expression", "by", "remodeling", "the", "chromatin", "structure", "(", "Salminen", "et", "al.", "2016", ")", "." ] } ]
PMC11683240	For control, cells were treated with α1AT and PT that were preincubated together before addition to cells, or α1AT and PT were added directly to the cells as it was done in the previous experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "control", ",", "cells", "were", "treated", "with", "α1AT", "and", "PT", "that", "were", "preincubated", "together", "before", "addition", "to", "cells", ",", "or", "α1AT", "and", "PT", "were", "added", "directly", "to", "the", "cells", "as", "it", "was", "done", "in", "the", "previous", "experiments", "." ] } ]
PMC10158546	RT-QuIC reactions were seeded in quadruplicate with 5 × 10, 5 × 10 and 5 × 10 grams total protein of ReN cell lysate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RT-QuIC", "reactions", "were", "seeded", "in", "quadruplicate", "with", "5", "×", "10", ",", "5", "×", "10", "and", "5", "×", "10", "grams", "total", "protein", "of", "ReN", "cell", "lysate", "." ] } ]
PMC11269933	The full-length CDSs of CgPk and CgErk were amplified and inserted into pCMV-N-mCherry and pCMV-N-EGFP plasmids for fusion with the reporter gene, respectively (Beyotime Biotechnology, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "full-length", "CDSs", "of", "CgPk", "and", "CgErk", "were", "amplified", "and", "inserted", "into", "pCMV-N-mCherry", "and", "pCMV-N-EGFP", "plasmids", "for", "fusion", "with", "the", "reporter", "gene", ",", "respectively", "(", "Beyotime", "Biotechnology", ",", "China", ")", "." ] } ]
PMC7612475	Taken together, our data demonstrate that the common tumor-associated mutation in SF3B1, K700E, recapitulates many of the cellular deficits that are characteristic of loss of BRCA1/2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "together", ",", "our", "data", "demonstrate", "that", "the", "common", "tumor-associated", "mutation", "in", "SF3B1", ",", "K700E", ",", "recapitulates", "many", "of", "the", "cellular", "deficits", "that", "are", "characteristic", "of", "loss", "of", "BRCA1/2", "." ] } ]
PMC11530949	An in-depth examination of the morphology of Ag-doped CuO NPs was conducted by TEM analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "in-depth", "examination", "of", "the", "morphology", "of", "Ag-doped", "CuO", "NPs", "was", "conducted", "by", "TEM", "analysis", "." ] } ]
PMC11769516	It was found that adding honey to the diet reduced LPO and levels of enzymes related to liver damage while increasing enzymatic and non-enzymatic antioxidants in rats that received both honey and AFs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "found", "that", "adding", "honey", "to", "the", "diet", "reduced", "LPO", "and", "levels", "of", "enzymes", "related", "to", "liver", "damage", "while", "increasing", "enzymatic", "and", "non-enzymatic", "antioxidants", "in", "rats", "that", "received", "both", "honey", "and", "AFs", "." ] } ]
PMC7215832	PMX is also first line treatment for patients with non-squamous NSCLC not eligible for treatment with one of the tyrosine kinase inhibitors such as erlotinib, gefitinib, or crizotinib .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PMX", "is", "also", "first", "line", "treatment", "for", "patients", "with", "non-squamous", "NSCLC", "not", "eligible", "for", "treatment", "with", "one", "of", "the", "tyrosine", "kinase", "inhibitors", "such", "as", "erlotinib", ",", "gefitinib", ",", "or", "crizotinib", "." ] } ]
PMC9429973	Summary/Conclusion: Pre/pro B-cell lines carrying kinase-dead Cdk6 (Cdk6-K43M) showed intermediate tumorigenic potential between lines with Cdk6-WT and Cdk6-KO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Pre/pro", "B-cell", "lines", "carrying", "kinase-dead", "Cdk6", "(", "Cdk6-K43", "M", ")", "showed", "intermediate", "tumorigenic", "potential", "between", "lines", "with", "Cdk6-WT", "and", "Cdk6-KO", "." ] } ]
PMC11700165	ITK-SYK is believed, like the native TFKs, to be regulated by the PI3-kinase signaling pathway (5,7,22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ITK-SYK", "is", "believed", ",", "like", "the", "native", "TFKs", ",", "to", "be", "regulated", "by", "the", "PI3-kinase", "signaling", "pathway", "(", "5,7,22", ")", "." ] } ]
PMC10033453	Three doses of 1e7 TCID50 were administered IT at days 0, 5, and 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "doses", "of", "1e7", "TCID50", "were", "administered", "IT", "at", "days", "0", ",", "5", ",", "and", "10", "." ] } ]
PMC9429973	The anti-tumor response after 2-6 courses of therapy with bortezomib-containing regimens was evaluated in 68 patients according to the IMWG (2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anti-tumor", "response", "after", "2", "-", "6", "courses", "of", "therapy", "with", "bortezomib-containing", "regimens", "was", "evaluated", "in", "68", "patients", "according", "to", "the", "IMWG", "(", "2016", ")", "." ] } ]
PMC3675084	BPR0L075 exhibits single agent antitumor activity against the growth of human gastric and cervical carcinoma xenografts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BPR0L075", "exhibits", "single", "agent", "antitumor", "activity", "against", "the", "growth", "of", "human", "gastric", "and", "cervical", "carcinoma", "xenografts", "." ] } ]
PMC9792775	The results suggested that LFU significantly enhanced intracellular concentrations of PTX (Figure 5F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "suggested", "that", "LFU", "significantly", "enhanced", "intracellular", "concentrations", "of", "PTX", "(", "Figure", "5F", ")", "." ] } ]
PMC9817179	The cell on the right shows an increase of 31 puncta, a change of 74%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "on", "the", "right", "shows", "an", "increase", "of", "31", "puncta", ",", "a", "change", "of", "74", "%", "." ] } ]
PMC11530949	In this study, the IC50 values of both Ephedra intermedia extract and the synthesized Ag-doped CuO NPs were determined using the MTT assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "the", "IC50", "values", "of", "both", "Ephedra", "intermedia", "extract", "and", "the", "synthesized", "Ag-doped", "CuO", "NPs", "were", "determined", "using", "the", "MTT", "assay", "." ] } ]
PMC9599726	When C11-BODIPY is oxidized, its emission fluorescence shifts from 591 nm (red) to 510 nm (green) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "C11-BODIPY", "is", "oxidized", ",", "its", "emission", "fluorescence", "shifts", "from", "591", "nm", "(", "red", ")", "to", "510", "nm", "(", "green", ")", "." ] } ]
PMC9429973	Aims: In this work, the aim was to identify this correlation using a molecular study of MTHFR polymorphisms in a Tunisian cohort with acute lymphoblastic leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "In", "this", "work", ",", "the", "aim", "was", "to", "identify", "this", "correlation", "using", "a", "molecular", "study", "of", "MTHFR", "polymorphisms", "in", "a", "Tunisian", "cohort", "with", "acute", "lymphoblastic", "leukemia", "." ] } ]
PMC11697189	The collaborative impact of combining risk scores and TMB in prognostic stratification was assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "collaborative", "impact", "of", "combining", "risk", "scores", "and", "TMB", "in", "prognostic", "stratification", "was", "assessed", "." ] } ]
PMC9429973	CD38 expression on blasts after daratumumab was not evaluated due to blast elimination in these cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD38", "expression", "on", "blasts", "after", "daratumumab", "was", "not", "evaluated", "due", "to", "blast", "elimination", "in", "these", "cases", "." ] } ]
PMC11388384	Microscopy was performed on a Nikon Ti2 with a 40x (NA 0.75) objective and a Zyla CMOS detector.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Microscopy", "was", "performed", "on", "a", "Nikon", "Ti2", "with", "a", "40x", "(", "NA", "0.75", ")", "objective", "and", "a", "Zyla", "CMOS", "detector", "." ] } ]
PMC10093184	In the present study, we isolated novel canine osteosarcoma cell lines from chemotherapy-naïve patients and compared them with the commercially available and well-characterized D-17 canine osteosarcoma cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "present", "study", ",", "we", "isolated", "novel", "canine", "osteosarcoma", "cell", "lines", "from", "chemotherapy-naïve", "patients", "and", "compared", "them", "with", "the", "commercially", "available", "and", "well-characterized", "D-17", "canine", "osteosarcoma", "cell", "line", "." ] } ]
PMC11723947	Thus, the establishment of a transcriptional signature in response to environmental cues is a progressive process driven by coordinated and highly specific gene-regulatory events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "the", "establishment", "of", "a", "transcriptional", "signature", "in", "response", "to", "environmental", "cues", "is", "a", "progressive", "process", "driven", "by", "coordinated", "and", "highly", "specific", "gene-regulatory", "events", "." ] } ]
PMC11629143	In this way, acetylation of histones associated with promoters can stimulate transcription steps that follow Pol II recruitment, which are often rate‐limiting for output.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "way", ",", "acetylation", "of", "histones", "associated", "with", "promoters", "can", "stimulate", "transcription", "steps", "that", "follow", "Pol", "II", "recruitment", ",", "which", "are", "often", "rate‐limiting", "for", "output", "." ] } ]
PMC11190238	The lack of simultaneous capture of epigenome, protein, and mRNA expression at single-cell depth in these studies may not adequately define the EMT states.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lack", "of", "simultaneous", "capture", "of", "epigenome", ",", "protein", ",", "and", "mRNA", "expression", "at", "single-cell", "depth", "in", "these", "studies", "may", "not", "adequately", "define", "the", "EMT", "states", "." ] } ]
PMC10507284	Therefore, it is necessary to comprehensively analyze the role of TROAP in STS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "it", "is", "necessary", "to", "comprehensively", "analyze", "the", "role", "of", "TROAP", "in", "STS", "." ] } ]
PMC10877303	The minimized protein structure was saved for executing additional molecular docking and molecular dynamics (MD) simulation schemes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "minimized", "protein", "structure", "was", "saved", "for", "executing", "additional", "molecular", "docking", "and", "molecular", "dynamics", "(", "MD", ")", "simulation", "schemes", "." ] } ]
PMC11707577	Cellular localization of M13EGFR(TNP) on A431 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Cellular", "localization", "of", "M13EGFR(TNP", ")", "on", "A431", "cell", "line", "." ] } ]
PMC9822769	The calculated PSA values obtained for the 1–3 compounds (116, 112, and 110 Å, respectively) confirm, albeit on a different scale, the previously observed trend (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "calculated", "PSA", "values", "obtained", "for", "the", "1–3", "compounds", "(", "116", ",", "112", ",", "and", "110", "Å", ",", "respectively", ")", "confirm", ",", "albeit", "on", "a", "different", "scale", ",", "the", "previously", "observed", "trend", "(", "Table", "2", ")", "." ] } ]
PMC10135767	A parallel plate flow chamber, together with a fluorescent detection system, was used to perform the adhesion experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "parallel", "plate", "flow", "chamber", ",", "together", "with", "a", "fluorescent", "detection", "system", ",", "was", "used", "to", "perform", "the", "adhesion", "experiment", "." ] } ]
PMC10887351	In another study, in a rabbit model, the preservation of the Na/K pump function, upon β3-AR stimulation, promoted the reduction of congestive cardiac remodeling, which was induced by coronary ligation , a phenomenon observed in a diabetic heart model, where the stimulation of β3-AR prevented the Na/K pump inactivation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "another", "study", ",", "in", "a", "rabbit", "model", ",", "the", "preservation", "of", "the", "Na/K", "pump", "function", ",", "upon", "β3-AR", "stimulation", ",", "promoted", "the", "reduction", "of", "congestive", "cardiac", "remodeling", ",", "which", "was", "induced", "by", "coronary", "ligation", ",", "a", "phenomenon", "observed", "in", "a", "diabetic", "heart", "model", ",", "where", "the", "stimulation", "of", "β3-AR", "prevented", "the", "Na/K", "pump", "inactivation", "." ] } ]
PMC7154001	Chromatography and electrophoresis are usually methods of choice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chromatography", "and", "electrophoresis", "are", "usually", "methods", "of", "choice", "." ] } ]
PMC10170482	It has become evident that physical stimuli of the cellular microenvironment transmit mechanical cues regulating key cellular functions, such as proliferation, migration, and malignant transformation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "become", "evident", "that", "physical", "stimuli", "of", "the", "cellular", "microenvironment", "transmit", "mechanical", "cues", "regulating", "key", "cellular", "functions", ",", "such", "as", "proliferation", ",", "migration", ",", "and", "malignant", "transformation", "." ] } ]
PMC11388384	Using timelapse imaging to track individual cells, we found that sender cells could transduce SHH signal to receiver cells in the presence of SCUBE1 despite never coming within ~100 µm of one another, suggesting that SHH diffused in the field of receiver cells (Fig. 3D and Movie S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "timelapse", "imaging", "to", "track", "individual", "cells", ",", "we", "found", "that", "sender", "cells", "could", "transduce", "SHH", "signal", "to", "receiver", "cells", "in", "the", "presence", "of", "SCUBE1", "despite", "never", "coming", "within", "~100", "µm", "of", "one", "another", ",", "suggesting", "that", "SHH", "diffused", "in", "the", "field", "of", "receiver", "cells", "(", "Fig.", "3D", "and", "Movie", "S2", ")", "." ] } ]
PMC6461034	Larger networks are shown in Appendix Figs S2–S5.Data information: In INKA plots proper, the vertical position of kinases (drivers in red) is determined by their INKA score, whereas the horizontal position is determined by the (im)balance of evidence from kinase‐centric and substrate‐inferred arms of the analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Larger", "networks", "are", "shown", "in", "Appendix", "Figs", "S2–S5.Data", "information", ":", "In", "INKA", "plots", "proper", ",", "the", "vertical", "position", "of", "kinases", "(", "drivers", "in", "red", ")", "is", "determined", "by", "their", "INKA", "score", ",", "whereas", "the", "horizontal", "position", "is", "determined", "by", "the", "(im)balance", "of", "evidence", "from", "kinase‐centric", "and", "substrate‐inferred", "arms", "of", "the", "analysis", "." ] } ]

PMC11394730

Quercetin is a dietary flavonoid that is commonly found in fruits and vegetables and is consumed in copious quantities in Western diets.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quercetin", "is", "a", "dietary", "flavonoid", "that", "is", "commonly", "found", "in", "fruits", "and", "vegetables", "and", "is", "consumed", "in", "copious", "quantities", "in", "Western", "diets", "." ] } ]

PMC11323699

Eight-week-old C57BL/6 J mice were IP injected with 2 × 10 ID8 Trp53 Brca2 cells in 300 µL HBSS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight-week-old", "C57BL/6", "J", "mice", "were", "IP", "injected", "with", "2", "×", "10", "ID8", "Trp53", "Brca2", "cells", "in", "300", "µL", "HBSS", "." ] } ]

PMC9429973

Patients with decreased or no change in Hb levels after 6 months of RAV experienced more inpatient visits (mean visits [SD]: 1.3 [2.0]) compared to patients with increased Hb levels (mean visits [SD]: 0.9 [1.5]).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "with", "decreased", "or", "no", "change", "in", "Hb", "levels", "after", "6", "months", "of", "RAV", "experienced", "more", "inpatient", "visits", "(", "mean", "visits", "[", "SD", "]", ":", "1.3", "[", "2.0", "]", ")", "compared", "to", "patients", "with", "increased", "Hb", "levels", "(", "mean", "visits", "[", "SD", "]", ":", "0.9", "[", "1.5", "]", ")", "." ] } ]

PMC11591038

HIF-1 is involved in the differentiation, migration, metabolism, and survival of dendrite cells under hypoxia and inflammation .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HIF-1", "is", "involved", "in", "the", "differentiation", ",", "migration", ",", "metabolism", ",", "and", "survival", "of", "dendrite", "cells", "under", "hypoxia", "and", "inflammation", "." ] } ]

PMC10452486

Not only was a 43 kDa HC precipitated without B2m by A1.4, but a novel 38 kDa molecule was as well.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Not", "only", "was", "a", "43", "kDa", "HC", "precipitated", "without", "B2", "m", "by", "A1.4", ",", "but", "a", "novel", "38", "kDa", "molecule", "was", "as", "well", "." ] } ]

PMC11095939

Lower panel: quantification of the percentage of 3T3 cells in the G0 phase.

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PMC11803918

Percentages of CD86 cells in CD11c dendritic cells and CD11b macrophages in the peripheral blood from humanized mice with different treatments. (

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PMC11746948

It has been observed that cancer cells transitioning into therapy-resistant states rely on GPX4, identifying it as a potential target in cancer therapy strategies.

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PMC10222971

Results of the ten naphthoquinones selected from the wheat coleoptile bioassay were assayed on HeLa cells for 24 h. are illustrated in Figure 3.

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PMC9429973

The median follow-up time was 9.7 (1.2 – 19.2) months for the TN cohort and 3.8 (0.3 – 9.6) months for the R/R cohort.

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PMC11591030

As shown in Figure 3, under non-stress conditions, supplementation with various concentrations of AOP significantly enhanced the expression of the CAT gene compared to the control group, with no significant difference compared to the VA treatment group (p < 0.05).

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PMC11395280

The data were normalized to the maximum Ca released in the presence of ionomycin.

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PMC11718031

Feed is added at certain time intervals to maximize the volumetric productivity and product titer.

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PMC10165258

The response of spheroids of Ewing sarcoma (EwS) A673 cells to simultaneous or sequential combinations of etoposide and cisplatin was evaluated.

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PMC11725127

Interestingly, preincubation of iodoacetic acid (IAA), a cysteine alkylating agent, with USP2 completely inhibited the binding of biotin-GA to USP2 (Supporting Information Fig. S8), suggesting that GA may covalently bind to the cysteine(s) of USP2, which is consistent with previous reports that GA can covalently bind to its targets through cysteine residues.

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PMC11435360

Furthermore, we investigated the effects of PAG in combination with GEM chemotherapy, a clinically used intravesical therapeutic agent for BC.

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PMC9429973

Results: 3D co-cultures of h- or AML-MSCs and AML blasts or HSCs showed that AML-MSCs strongly supported AML cells proliferation (by Ki67), but decreased normal HSCs proliferation (reduction of 32%).

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PMC11206251

After washing, the membranes were further incubated with secondary antibodies at room temperature for 1 h. Finally, the protein bands were visualized using an Omni-ECLTM ultrasensitive chemiluminescence detection kit (Epizyme, Shanghai, China) by an imaging system (Bio-Rad, Hercules, CA, USA).

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PMC9681981

A P-value less than 0.05 was considered statistically significant.

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PMC10747139

Moreover, the modulation activity of amyloid-β aggregation has been described, which can be useful in the treatment of Alzheimer’s disease .

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PMC10523483

Representative IHC images of 8-OHdG staining in K and KH lung tumors. (

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PMC11513011

Antitumor effects on 5637 need to be investigated further.

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PMC11798926

Cultures were then fixed with 4% PFA and 4% sucrose in PBS for 10 min at RT, followed by three washes in RT PBS.

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PMC8956657

Anti-rabbit and anti-mouse IgG, HRP-linked antibodies were purchased from Cell Signaling (cat# 7074 and 7076).

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PMC11721277

The lipophilic radiometabolites of the HYNIC-chlorin complex can quickly leak through the cell membrane.

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PMC11585565

The relative expression levels of WT and mutant CNNM4 mRNAs showed no significant difference at 24-hours post-transfection.

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PMC11190538

This could verify the protein nature of the extracted C-PC.Fig.

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PMC10094992

The expected minimum detectable concentration of IL-8 for this set is 8 pg/mL. Human neutrophils were collected and isolated from venous blood samples from healthy volunteers.

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PMC9429973

Secondary end point was objective response rate (ORR).

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PMC7685376

We also analyzed candidate expression after Huaier treatment in HCC cells by WB and qRT-PCR.

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PMC9429973

During the study follow-up (median 101 days; range 21-222) 84 patients deceased after a median time of 14 days (IQR: 8-49, range 0-457) since COVID-19 diagnosis.

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PMC8143558

ex Oliv in South Africa ; Helinus integrifolia (Lam) Kuntze in South Africa and Senna obtusifolia L. in South Africa .

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PMC8633974

Added value of this studyCRISPR-Cas9 gRNAs designed against multiclade HIV-1 consensus sequences were proven effective against a broad range of viral strains.

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PMC11721064

2Molecular phenotype characterization of LNCs.

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PMC11257203

Subsequently, the plates were incubated for 20 h under the conditions of 5% CO2 air at 37 °C.

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PMC11013014

Despite significant advancements in therapeutic interventions, drug resistance and adverse side effects remain arduous obstacles.

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PMC10582049

Grout et al. identified that ADH1B CAFs had a high expression of IL34, CSF1, CCL19, CCL21, and CXCL12.

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PMC11248911

The screening of the molecules was completed using PyRx 0.8.

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PMC11544122

a Agonist stimulated endocytosis of CXCR4, β2AR, and AT1AR was examined in HEK293 cells transfected with control siRNA (siCon) or two combinations of siRNA against SNX9 and SNX18.

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PMC10728200

Yet, there is limited research on ferroptosis in GIST, and the underlying mechanism remains unclear.

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PMC11359735

C, a representative extracted ion chromatogram (EIC) of the CSP-3 sample, where m/z 305 and m/z 318 represent the native H6-myo-inositol of the CSP-3 sample and m/z 307 and 321 represent the D6-myo-inositol internal standard.

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PMC11752740

SK-BR3 and MCF10A cells were plated at a density of 2.5 × 10 cells per well in a 6-well plate, using 200 µl of complete medium.

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PMC11782508

EDX analysis. (

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PMC9532503

ADCC is the most important mechanism of action for the efficacy of these antibodies in B cell lymphoma patients.

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PMC11762280

Therefore, our study further confirmed the complexity of keratinocyte RCDs after UVB irradiation, including GSDME-mediated pyroptosis , ferroptosis , and PANoptosis, among which PANoptosis is the key lethal modality leading to keratinocyte death.

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PMC9884169

AMPK is responsible for controlling and regulating the energy supply system of cells, which at the same time responds to the environment, improving the adaptability of cells themselves .

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PMC9429973

Data on comorbidities, baseline laboratory parameters, and indication for performing a bone marrow culture were extracted from the institution’s electronic medical records system.

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PMC11585587

The results of CCK-8 showed that RA inhibited the proliferation of MM cells, including MM.1 S, MM1R, and RPMI 8226 cells, in a time-dependent and concentration-dependent manner.

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PMC11767725

Significant improvements in HS severity were observed, with Hurley stage scores decreasing from 2.6 ± 0.5 to 1.1 ± 0.3 (p = 0.002), and Dermatology Life Quality Index (DLQI) scores improving from 12.3 ± 2.8 to 9.7 ± 6.9 (p = 0.04).

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PMC11575040

The Venn diagram illustrates that 41 upregulated lncRNAs and 14 downregulated lncRNAs were concurrently identified in two melanoma cell lines (A2058 and A375) following metformin treatment (Fig. 1A).Fig.

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PMC10218459

To analyze the underlying mechanism of cell death, the apoptosis detection methods TUNEL and caspase 3/7 activation assay were used.

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PMC9429973

The differential diagnostic was continued among hemolytic-uremic syndrome, TTP, cancer, autoimmune disorder and viral infections.

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PMC11789597

viSNE analysis was used to visualize these high‐dimensional mass cytometry data in 2D, and seven T or NK cell subsets were identified (Figure 3C–E; Figure S4A, Supporting Information).

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PMC11092382

Therefore, sophocarpine may be used as a potential reagent for treating prosthesis loosening (Zhou et al., 2018).

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PMC11721295

CAFs support tumor growth through paracrine signaling.

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PMC11775197

↓ indicates inhibition and ↑ indicates increase.

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PMC11763126

A IP combined with mass spectrometry revealed that usp5 binds to YTHDF2.

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PMC9436459

Kuwanon H (93), multicaulisin (99), and sanggenon G (124) were found to possess potent effect against ten clinical MRSA strains with MICs/MBCs of 2–8/16–128 mg/L, and also showed synergy with conventional antibacterial agents such as aminoglycosides .

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PMC8584319

Furthermore, refametinib pre-treatment before AZD8055 exposure led to a dose-dependent synergistic effect on translational inhibition (Figure 4a).

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PMC11473843

All data presented are expressed as mean ± SD (unless indicated in the figure legends) of 3 or more biologically independent replicates/group (the specific number is indicated in the related figure legends).

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PMC11474209

Cyanotoxins are produced by cyanobacteria found in lakes and oceans, and they can rapidly reproduce in high phosphorus concentrations.

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PMC9429973

Image: Summary/Conclusion: NFκB is an exciting target but challenging drug target due to its heterogenous activity in DLBCL cases and importance in normal cellular functions.

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PMC9429973

It is widely accepted that a sustained deep molecular remission (DMR) is the pre-requisite to discontinue TKI, and it is expected that in patients who start treatment with imatinib (IMA) and fail early molecular remission (EMR), a switch to a second generation TKI may improve the probability of achieving a DMR Aims: We launched in November 2016 an international, prospective, interventional, randomized, two arms, study to evaluate both the depth of the molecular response and the rate of TFR in newly diagnosed CP-CML patients treated with a second generation TKI (Nilotinib, NIL) or with IMA followed by switching to NIL in absence of optimal response (defined according the ELN 2013 criteria (Clinical Trial number 02602314).

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PMC11779605

Purple indicates genes that are downregulated in the tumor compared to those in the ascites.

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PMC9429973

Second, co-culture with LN-derived stromal cells further increased CLL proliferation, reaching a maximum of 8 generations.

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PMC11411004

The level of gene transcription is correlated with the histone acetylation status of the promoter (Shvedunova and Akhtar 2022), which induces gene expression by remodeling the chromatin structure (Salminen et al. 2016).

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PMC11683240

For control, cells were treated with α1AT and PT that were preincubated together before addition to cells, or α1AT and PT were added directly to the cells as it was done in the previous experiments.

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PMC10158546

RT-QuIC reactions were seeded in quadruplicate with 5 × 10, 5 × 10 and 5 × 10 grams total protein of ReN cell lysate.

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PMC11269933

The full-length CDSs of CgPk and CgErk were amplified and inserted into pCMV-N-mCherry and pCMV-N-EGFP plasmids for fusion with the reporter gene, respectively (Beyotime Biotechnology, China).

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PMC7612475

Taken together, our data demonstrate that the common tumor-associated mutation in SF3B1, K700E, recapitulates many of the cellular deficits that are characteristic of loss of BRCA1/2.

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PMC11530949

An in-depth examination of the morphology of Ag-doped CuO NPs was conducted by TEM analysis.

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PMC11769516

It was found that adding honey to the diet reduced LPO and levels of enzymes related to liver damage while increasing enzymatic and non-enzymatic antioxidants in rats that received both honey and AFs.

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PMC7215832

PMX is also first line treatment for patients with non-squamous NSCLC not eligible for treatment with one of the tyrosine kinase inhibitors such as erlotinib, gefitinib, or crizotinib .

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PMC9429973

Summary/Conclusion: Pre/pro B-cell lines carrying kinase-dead Cdk6 (Cdk6-K43M) showed intermediate tumorigenic potential between lines with Cdk6-WT and Cdk6-KO.

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PMC11700165

ITK-SYK is believed, like the native TFKs, to be regulated by the PI3-kinase signaling pathway (5,7,22).

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PMC10033453

Three doses of 1e7 TCID50 were administered IT at days 0, 5, and 10.

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PMC9429973

The anti-tumor response after 2-6 courses of therapy with bortezomib-containing regimens was evaluated in 68 patients according to the IMWG (2016).

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PMC3675084

BPR0L075 exhibits single agent antitumor activity against the growth of human gastric and cervical carcinoma xenografts .

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PMC9792775

The results suggested that LFU significantly enhanced intracellular concentrations of PTX (Figure 5F).

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PMC9817179

The cell on the right shows an increase of 31 puncta, a change of 74%.

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PMC11530949

In this study, the IC50 values of both Ephedra intermedia extract and the synthesized Ag-doped CuO NPs were determined using the MTT assay.

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PMC9599726

When C11-BODIPY is oxidized, its emission fluorescence shifts from 591 nm (red) to 510 nm (green) .

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PMC9429973

Aims: In this work, the aim was to identify this correlation using a molecular study of MTHFR polymorphisms in a Tunisian cohort with acute lymphoblastic leukemia.

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PMC11697189

The collaborative impact of combining risk scores and TMB in prognostic stratification was assessed.

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PMC9429973

CD38 expression on blasts after daratumumab was not evaluated due to blast elimination in these cases.

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PMC11388384

Microscopy was performed on a Nikon Ti2 with a 40x (NA 0.75) objective and a Zyla CMOS detector.

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PMC10093184

In the present study, we isolated novel canine osteosarcoma cell lines from chemotherapy-naïve patients and compared them with the commercially available and well-characterized D-17 canine osteosarcoma cell line.

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PMC11723947

Thus, the establishment of a transcriptional signature in response to environmental cues is a progressive process driven by coordinated and highly specific gene-regulatory events.

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PMC11629143

In this way, acetylation of histones associated with promoters can stimulate transcription steps that follow Pol II recruitment, which are often rate‐limiting for output.

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PMC11190238

The lack of simultaneous capture of epigenome, protein, and mRNA expression at single-cell depth in these studies may not adequately define the EMT states.

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PMC10507284

Therefore, it is necessary to comprehensively analyze the role of TROAP in STS.

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PMC10877303

The minimized protein structure was saved for executing additional molecular docking and molecular dynamics (MD) simulation schemes.

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PMC11707577

Cellular localization of M13EGFR(TNP) on A431 cell line.

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PMC9822769

The calculated PSA values obtained for the 1–3 compounds (116, 112, and 110 Å, respectively) confirm, albeit on a different scale, the previously observed trend (Table 2).

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PMC10135767

A parallel plate flow chamber, together with a fluorescent detection system, was used to perform the adhesion experiment.

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PMC10887351

In another study, in a rabbit model, the preservation of the Na/K pump function, upon β3-AR stimulation, promoted the reduction of congestive cardiac remodeling, which was induced by coronary ligation , a phenomenon observed in a diabetic heart model, where the stimulation of β3-AR prevented the Na/K pump inactivation .

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PMC7154001

Chromatography and electrophoresis are usually methods of choice.

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PMC10170482

It has become evident that physical stimuli of the cellular microenvironment transmit mechanical cues regulating key cellular functions, such as proliferation, migration, and malignant transformation.

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PMC11388384

Using timelapse imaging to track individual cells, we found that sender cells could transduce SHH signal to receiver cells in the presence of SCUBE1 despite never coming within ~100 µm of one another, suggesting that SHH diffused in the field of receiver cells (Fig. 3D and Movie S2).

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PMC6461034

Larger networks are shown in Appendix Figs S2–S5.Data information: In INKA plots proper, the vertical position of kinases (drivers in red) is determined by their INKA score, whereas the horizontal position is determined by the (im)balance of evidence from kinase‐centric and substrate‐inferred arms of the analysis.

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