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OTAR3088
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BioData-CellLine_annotated

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PMC11640115
Next, in order to investigate the utility of the imGPS as a predictive marker for therapeutic effect, the previously reported NLRs and mGPSs were also examined for a correlation with the therapeutic effect of pembrolizumab.
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PMC11532793
The first is that bootstrap resampling adds considerably to computational time and therefore dissipates one of the key advantages of the lightweight alignment tools.
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PMC5941560
Pindel’s small insertion calls were merged if they directly overlapped, and the longest insertion length of the merged variants was used for the new variant annotation.
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PMC8753818
Hence, in the study at hand the effect of caspase-7 deficiency was assessed on the cell growth, viability and protein expression.
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PMC11257203
Phytohemagglutinin (PHA) and fetal bovine serum (FBS) were purchased from Gibco (Life Technologies, USA).
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PMC8956657
The NF-κB p50 NLS region (UniProtKB P19838; residues 331–370) was codon optimized for expression in E. coli, synthesized with an added N-terminal TEV cleavage site, and cloned into pGEX4T-1 vector at BamHI and EcoRI sites (Genscript, Piscataway, NJ).
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PMC9325715
Such studies may provide knowledge about the fate of iron in products fortified with microelements.
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PMC9429973
From each patient we obtained the stool speciments before and after HSCT.
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PMC11323699
Histograms showing quantification of CD47 expression (right panel).
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PMC10988555
The membranes were incubated with WesternBright ECL subtract (Advansta) for 5 min in the dark and the film was exposed to the membranes in a dark room.
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PMC11394386
Their intricate structure enables them to regulate transcriptional and epigenetic mechanisms by interacting with DNA, RNA, and proteins.
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PMC11548041
Given that the homodimer is the predominant species, these residues might not be available for aptamer binding, thus highlighting the importance of performing modeling studies with both EpEX species.
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PMC11638255
Significance was calculated using a two-tailed t-test with Welch’s correction with p-value displayed in the figure.
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PMC11352877
The cell lines 12Z (p < 0.0001) and A2780 (p < 0.0001) expressed significantly elevated VEGF-A mRNA compared to HME1.
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PMC4485786
This differentiation toward functional muscle tissue was even more pronounced in sarcomas from mice treated with NHS-IL12/IL-2MAB602.
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PMC11705067
To understand the relationship between FDX1 and DLAT in cellular immunity, the potential correlation of their expression with 24 types of immune cells was analyzed by ssGSEA from the R package with a Spearman test.
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PMC11532793
Total processing time per library for Salmon quantification with either bootstrap or Gibbs resampling methods The total processing time (in minutes) is given for bootstrap and Gibbs resampling and for different library sizes.
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PMC9429973
Those who have been treated with midostaurin or other multikinase inhibitors are eligible, though pts who failed to achieve at least a partial response or who relapsed following prior exposure to gilteritinib or other next-generation FLT3 inhibitor monotherapy are excluded.
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PMC8662250
Results are expressed as mean ± standard deviation (SD) of n = 4 experiments performed in triplicate. ***
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PMC11139449
The expression of JRed was assessed using flowcytometry (Beckman Coulter FC500; Beckman Coulter) at 72 hours after transfection.
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PMC9031474
In this context, Montenegro et al. observed higher mitochondrial membrane permeabilities in cancer cells after treatment with polygodial (2) and two other drimanes .
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PMC11538390
The FinnGen study is approved by the Finnish Institute for Health and Welfare (THL, permit numbers [PN]: THL/2031/6.02.00/2017, THL/1101/5.05.00/2017, THL/341/6.02.00/2018, THL/2222/6.02.00/2018, THL/283/6.02.00/2019, THL/1721/5.05.00/2019 and THL/1524/5.05.00/2020); the Digital and Population Data Services Agency (PN: VRK43431/2017-3, VRK/6909/2018-3, VRK/4415/2019-3); the Social Insurance Institution (PN: KELA 58/522/2017, KELA 131/522/2018, KELA 70/522/2019, KELA 98/522/2019, KELA 134/522/2019, KELA 138/522/2019, KELA 2/522/2020, KELA 16/522/2020); Findata (PN: THL/2364/14.02/2020, THL/4055/14.06.00/2020, THL/3433/14.06.00/2020, THL/4432/14.06/2020, THL/5189/14.06/2020, THL/5894/14.06.00/2020, THL/6619/14.06.00/2020, THL/209/14.06.00/2021, THL/688/14.06.00/2021, THL/1284/14.06.00/2021, THL/1965/14.06.00/2021, THL/5546/14.02.00/2020, THL/2658/14.06.00/2021, THL/4235/14.06.00/2021); Statistics Finland (PN: TK-53-1041-17 and TK/143/07.03.00/2020 [earlier TK-53-90-20], TK/1735/07.03.00/2021, TK/3112/07.03.00/2021) and the Finnish Registry for Kidney Diseases (permission/extract from the meeting minutes on July 4, 2019).
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PMC9429973
Aims: We describe the characteristics and outcomes of patients with AML or high risk myelodysplastic syndrome (HR-MDS) receiving Ven combinations in frontline and R/R settings to provide real-world insight into their use in UK clinical practice.
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PMC11472569
ABCG2, also known as BCRP, is a “half-transporter” featuring a single NBD and a single TMD.
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PMC11342785
Prior to the addition of rapamycin, TPPP FL-FKBP was distributed throughout the cytoplasm and partially decorated MTs at the nuclear periphery (53).
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PMC11306019
The values of PC1, PC2, and PC3 for all polyphenols were then plotted using Grapher 2.5 (Mac OS) to generate three-dimensional (3D) plots depicting the ChemGPS-NP chemical property space.
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PMC11759543
5637 and BFTC 905 cells were pretreated with either the pan caspase inhibitor, Z-VAD-FMK (40 μM), caspase-8 inhibitor Z-IETD-FMK (40 μM), or caspase-9 inhibitor Ac-LEHD-CMK (40 μM), or ROS scavenger NAC (10 mM) for 1 h before doxorubicin or/and vorinostat was added.
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PMC11741906
Moreover, PI3K-Akt signaling pathway was found to be regulated by miRNAs that were identified to be correlated to cisplatin resistance in ovarian cancer cells.
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PMC10907726
In recent years, although some progress has been made in exploring the molecular functions of DATS in OS [, , ], the underlying mechanism remains unclear.
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PMC11746948
a Cell viability analysis in A375 cells infected with lentiviruses encoding control, APT1, APT2, ABHD17A, ABHD17B, ABHD17C, and ABHD10 shRNA, followed by 48 h RSL3 treatment.
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PMC11063646
The PBS was decanted and the cells were analyzed by flow cytometry using the 488 nm laser for excitation and detection at 535 nm (Chaharband et al., 2018).
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PMC6222726
Bursera fagaroides is used to alleviate inflammation, skin tumors, and warts, and is perhaps the most studied Bursera species in terms of its chemistry and biological effects.
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PMC9429973
Nine pts proceeded to subsequent alloSCT.
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PMC11469524
We found that from 18 identifiable coefficient (path)s that are present in the BL-2 network model aside from receptor-proximal signaling (Fig 5C TOP), 15 (83%) and 16 (89%) coefficient (path)s were also required in HBL-1 and OCI-LY3 cell line models, respectively.
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PMC10048572
Due to the wide range of mutations, all of them are characterized by a low allele frequency, below 10% (Figure 3 and Figure 4), and affect an average of 1–2% of the cell population, that complicates their identification in routine practice.
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PMC11218145
Differences in survival were statistically significant, as determined by log-rank analysis (p < 0.05) NOD-SCID female mice were injected i.p.
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PMC10877303
Fig. 7 (c) indicates that the CID-14335962 (3-beta-O-(trans-p-Coumaroyl) maslinic acid)-3CL complex exhibited a higher Rg and more flexibility, whereas the other two complexes demonstrated the rigid nature of the complexes.
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PMC10882807
Overexpression plasmids, human hsa_circ_0005397 cDNA was synthesized and cloned into the pcDNA3.1 vector (pcDNA) and empty vector was used as the negative control (vector) which obtained from Shanghai (Gechem, China).
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PMC8623816
Gene AG1IA_09435 was supposed to encode a sulfotransferase family domain-containing protein.
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PMC11640476
To select the best λEx-λEm, results were analyzed based on the cell confluency.
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PMC7171147
We identified that binding of COL11A1 to its receptors, α1β1 integrin and discoidin domain receptor 2 (DDR2), activates Src-Akt-AMPK signaling to increase the expression of both fatty acid synthesis and oxidation enzymes, although DDR2 seems to be the predominant receptor.
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PMC3164356
Sequence Read Archive: SRA040022.1 for assembly raw data and SRA040045.1 for transcriptome.
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PMC9964654
30% loss of cellular viability only at the highest concentration of 2 mg/mL. Overall, these results show that [Au(cdc)2] is still able to maintain its cytotoxic activity after micelle encapsulation.
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PMC9429973
Results: Among 173 young pts followed with MM, 18 had SCC (10%) which was inaugural in 5 pts (27% of cases).
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PMC11224020
For the NLS–GFP construct, pTRIP-SFFV-EGFP-NLS was generated introducing the SV40 NLS sequence (PKKKRKVEDP) by overlapping PCR at the C terminus of GFP in pTRIP-SFFV.
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PMC9429973
The presence of neurological symptoms, fever, high troponin levels, low hemoglobin, a raise of LDH and low platelet counts did not interfere significantly on the PFS and GS.
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PMC11754432
Media was changed every 3 days for 28 days.
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PMC4485786
We found the activating receptors NKG2E, NKp44, and NKp46 only in tumors of mice treated with NHS-IL12/FcIL-7, whereas NKp30 expression was restricted to sarcomas of NHS-IL12/IL-2MAB602-treated and NHS-IL12/FcIL-7 long-term treated mice (Fig. 3A).
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PMC10778532
Healing ability is significantly slowed down regardless of VHL status.
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PMC7171147
N = 2.
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PMC11489175
However, too large substrates can bypass this loop-mediated obstacle via their unfolding 33.
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PMC9895440
In agreement, we also observed lower PLCγ1 phosphorylation (upstream initiator of calcium/NFAT signaling) with SNX9 KO cells in response to intermediate anti-CD3+ anti-CD28 stimulation as well as high anti-CD3 stimulation alone (Fig. 3k).
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PMC10812665
Data showing unspecific neurite degeneration as a consequence of cell death are automatically excluded .
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PMC11438317
In line with previous findings, we found increased phosphorylation in Tyr493 of ZAP70 .
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PMC8389560
It is known that Cx43, together with aquaporin-4, are involved in the formation of glioma-induced brain edema .
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PMC9429973
Methods: We present a 58-year-old male diagnosed with B-CLL stage A (0) in November 2020, under hematologic regular monitoring with no specific therapy since November 2021.
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PMC9429973
Périgueux, Périgueux; CH Cornouaille, Quimper; CH.
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PMC9780037
On the other hand, PEGs are considered remarkably safe, a quality that makes them frequently used in cosmetic products .
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PMC11489351
C, trypan blue exclusion assay to assess the viability of cells treated as in (B).
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PMC11574271
Representative images were obtained at a magnification of 40× (Scale bar 1 µm).
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PMC11711871
Differences were assessed at *P < 0.05 and **P < 0.01 GR rats presented adrenal hyperplasia of the cortex and the medulla accompanied by a trend toward an increase in the plasma glucocorticoid concentration under standard diet.
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PMC10443665
But there is a controversy about the role of MDR1 in clinical outcome failure in patients with ALL (44445).
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PMC10812665
For instance, various ETC inhibitors triggered quite diverse metabolite responses .
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PMC11240448
The connection coefficients cannot be directly measured, because a perturbation to any module rapidly propagates, blurring the causality of connections .
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PMC11185260
Importantly, treatment of SMARCB1-expressing Hs729 cells with the scL-SMARCB1 nanocomplex did not induce antitumor activity with an IC50 value of >250ng of DNA/well, suggesting that SMARCB1 re-expression does not produce antitumor effects in SMARCB1-expressing cells.
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PMC10507284
However, with the extension of treatment duration, the drug resistance of cancer cells is enhanced, ultimately leading to treatment failure.
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PMC10154881
Lymphocytes and splenocytes of MOCK‐ or rMV‐SLAMblind treated‐E.G‐7/N4‐bearing mice were co‐cultured with OVA peptide‐pulsed DC (OVA‐DC).
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PMC10944868
Maestro (Frisch et al., 2016) graphic interface was used, and the Glide 6.9 application (Schrodinger Release, 2015-1: Glide, 2015a) in XP mode (extraprecision) (Friesner et al., 2006) was chosen for the docking.
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PMC11321678
In Group 3 clusters, LHX2 shows both high gene scores and high regulatory activity.
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PMC11695623
B,C) heat map of 10 genes with the strongest positive and negative correlation with DCUN1D5 expression in TCGA-LUAD data set. (
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PMC9429973
BOS safety profile may be an added value in this setting, but a fixed initial dose of 500 mg OAD may be higher than necessary.
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PMC11240571
Circulating exosomal PD-L1 (anti-mouse) expression (46 kDa) was maximal three days after irradiation (Supplemental Figure S10).
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PMC11650848
The processing of the RNA sequencing (RNA-Seq) data was performed on the usegalaxy platform (usegalaxy.com).
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PMC11761919
LMH cells with and without virus served as controls.
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PMC11365427
A, F) Schematic of the in vivo experiments. (
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PMC11534035
Of the 1,000 seeded A431 cells in the control group, an average of 353.8±26.51 colonies were formed over the course of 7 days (Figure 3A).
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PMC4816271
Data shown as means +/-SEM from 4 independent experiments with different donors.
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PMC11345828
Control wells were treated with DMSO only.
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PMC10291556
Table 1 shows IC50 (concentration of compound that causes death in 50% of cells) values determined using an MTT assay after a 72 h treatment.
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PMC11190538
As related to the topical interest of public health professionals about functional food products from renewable, sustainable sources and their biotherapeutic activity, C–C-phycocyanin (C-PC) from the blue-green edible algae Spirulina platensis was extracted and characterized for its biotherapeutic potential.
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PMC11746948
Both the large and small intestines were harvested for imaging, and the number of tumors in the intestines was quantified.
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PMC3019555
The percentage of HIF-1α mRNA in P-bodies was calculated as follows: percentage of Ago2-bound HIF-1α mRNA = (Ago2-bound mRNA/[bound + unbound mRNA]) × 100.
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PMC8658661
Moreover, there is no technique enabling the maintenance of liver biopsies in culture for time-consuming studies .
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PMC11711127
A majority of the lifetime of peripheral T lymphocytes is spent in quiescence.
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PMC10898159
LMTK3 also accelerates the translation rate of the KIT gene, resulting in secondary mutations that further leads to KIT resistance to IM .
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PMC6742971
Figure 2B presents the compiled data of three independent experiments, revealing similar results with only small differences (statistically not significant) between the conditions with different ratios of low and high avidity clones.
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PMC5854676
The last two columns were used as controls, i.e., without treatment.
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PMC6133382
Twenty-four hours post electroporation, the culture was supplemented with 1 mM sodium butyrate (Thermo Fisher, Life Technologies, Carlsbad, CA, US), and the temperature was lowered to 32 °C.
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PMC11723947
Taken together, these in vivo data suggest that HP1γ reduces the susceptibility of human CD4 T cells to immunosuppressive signals, and that targeting this molecule could be clinically relevant for repressing pathogenic T cell responses in bone marrow transplanted individuals or in patients suffering from autoimmunity.
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PMC11781181
Lipid peroxidation levels were determined with a lipid peroxidation assay kit (ab243377, Abcam) according to the manufacturer's instructions.
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PMC10899471
Compared to the control mice, the miR-939-3p group exhibited larger tumor volumes and weights ( Figures 6A–C ).
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PMC11724582
Furthermore, we cultured lung cancer cells with CM collected from NC, CAF, or H1975 cells after transfection with siRNA.
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PMC6163708
Our results suggest that HH signaling participates in preventing cell death perhaps in more than half of all tumors cell lines.
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PMC9429973
Dose escalation was planned to evaluate 3 dose levels of quizartinib (30, 40 and 60mg, respectively) administered on days 1-28 of every cycle in combination with azacitidine (75 mg/m2/day) on days 1-5 each 28-day cycle.
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PMC11546117
For this reason, primary cells could offer a more predictive in vitro model for determining human M/P ratios.
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PMC9429973
31 samples from severe SCD patients (SS, Sβ) were further analyzed for correlation with HU (7 HU-, 24 HU+) and HbF. Mean and SD values are shown in Table 1.
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PMC11279598
Human MCF-7 cells were inoculated subcutaneously at 2 × 10 cells/animal into the dorsal area of 6-week-old female athymic nude mice (Charles River Laboratories) primed with 0.36 mg s.c.
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PMC11739696
In particular, Co3O4NPs have shown promise as agents in cancer therapy due to their ability to induce selective cytotoxicity in human cancer cells.
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PMC9429973
The PFS and OS observed for gain/amp 1q21 and del17p in the RVd control arm may serve as important benchmarks for future enrichment design HRMM clinical trials.
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PMC11670954
Following a 2-hour incubation at 37°C in the dark, the absorbance was measured at 450 nm using a microplate reader (Thermo Scientific, USA).
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