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PMC11026382
Fig. 5Global comparison of the biochemistry-to-growth model and deep mutational scanning data set.a Correlation between the experimentally measured and predicted growth rates of 114 DHFR/TYMS mutant combinations.
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PMC6642070
To verify the observed increased lactate levels in mice with lovastatin treatment, we measured lactate production in mouse C2C12 myotubes and human A-204 rhabdomyosarcoma cell lines, both were widely used in muscle biology studies.
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PMC11756907
In the anticancer in vitro efficacy studies, it was observed that the solutions of GO-2ME and rGO-2ME in DMSO increased their anticancer efficacy against A375 and 143B cells compared to their solutions in ethyl alcohol.
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PMC11525028
Proliferation assay of NAT10-KO 143B (left) or HOS (right) cells (n = 3). (
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PMC9429973
For liso-cel–treated patients, median age was 74 years (range, 53–84; 79% ≥ 70 years) and 69%, 26%, and 5% met 1, 2, and 3 frailty criteria, respectively; 26% had ECOG PS of 2 and 44% had Hematopoietic Cell Transplantation-specific Comorbidity Index score ≥ 3.
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PMC10854447
Results demonstrated that most of the tested compounds showed significant antiproliferative action with GI50 values ranging from 28 to 104 nM, compared to Erlotinib (GI50 = 33 nM), and compounds 7i–m were the most potent.
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PMC9966931
In the case of Aspergillus niger, all hybrids exerted medium to low bioactivity.
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PMC11483468
Briefly, cells were fixed for 15 min at room temperature and then washed three times and stained with β-gal dye for 12 h. The stained cells were viewed under a microscope, and counted by ImageJ software (version 1.8.0).
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PMC11562028
Meanwhile, two distinct absorption peaks appear at ∼226 nm and ∼287 nm in the Re-CDs solution (Fig. 1E) due to the π–π* and n–π* transitions, respectively.
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PMC6835428
In the HeyA8 and SKOV3 variants which are PTX resistant (HeyA8-MDR1 and SKOV3 TR), the authors showed that the presence of siFAK improved the effects of PTX.
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PMC11753949
The narrow lumen is not a fixation artifact, as live imaging of SALs in cells also expressing the luminal marker, DsRed-KDEL showed absence of this marker from SALs.
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PMC9429973
It is necessary to evaluate this signature in new AML cohorts and to test its performance compared with standard risk stratification scores.
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PMC9429973
One of the most promising explanations involves modulation of unfolded protein response (UPR) pathway.
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PMC11607321
In contrast, other omics such as proteomics and metabolomics are more loosely structured by tissue.
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PMC11594074
As the presence of tumor metastasis is closely linked to poor survival prognosis, the link between cell migration and compound 4 was analyzed.
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PMC9429973
C. Harrison, J.-J. Kiladjian, A. M. Vannucchi, R. A. Mesa, R. M. Scherber, J. Hamer-Maansson, S. Verstovsek Guy’s and St. Thomas’ NHS Foundation Trust, Guy’s Hospital, London, United Kingdom; Hôpital Saint-Louis, Assitance Publique – Hôpitaux de Paris, Université de Paris, Inserm, Paris, France; CRIMM, Center for Research and Innovation of Myeloproliferative Neoplasms, AOU Careggi, University of Florence, Florence, Italy; Mays Cancer Institute at UT Health San Antonio MD Anderson, San Antonio; Incyte Corporation, Wilmington; The University of Texas MD Anderson Cancer Center, Houston, United States of America Background: Myelofibrosis (MF) is characterized by cytopenias, splenomegaly, burdensome symptoms, and poor overall survival (OS).
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PMC11742670
Each compound is represented by SMILE notation which is then converted into descriptors for model training.
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PMC11588085
Our study uses a stably established XIST KD cell line, which could explain these differences, indicating that the function of XIST may vary between immediate XIST KD and established XIST KD.
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PMC10125312
As seen in this paper, differential uptake and sensitivity to the nanomaterial translate to cell type susceptibility in PPTT.
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PMC11127909
A total of 1 × 10 cells were seeded in each well of 96-well plates.
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PMC9429973
Methods: This was a retrospective longitudinal cohort study using the IQVIA PharMetrics Plus database, which contains adjudicated claims from over 190 million unique patients in the US.
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PMC11585565
The results showed a rapid decrease in relative fluorescent signals within WT-transfected cells upon Mg removal (Fig. 2f, Supplementary Table S5).
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PMC11666785
Region-wise (R1, R2, R3) comparison of SMLM and corrSMLM reconstructed images and video are shown in Supplementary Note 3 and Supplementary Video 7.
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PMC11423992
The expression level of CD20 on tumor cell lines was compared using FACS analysis. (
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PMC10178190
High levels of PBX1 expression in clinical samples are correlated with poor survival rates.
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PMC11271278
This could be a strategy to further sensitize the tumor to HER2 inhibitors, or it could disastrously increase growth factor driven proliferation.
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PMC11342785
The line profile for each time point is used to generate a trajectory (right) showing the single-cell MT bundling dynamics (normalized intensity of SiR-tubulin signal at the cell center) generated by the synMAP circuit over time.
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PMC6181431
Activation of mTORC1 leads to protein synthesis, lipid synthesis, nucleotide synthesis, autophagy inhibition, leading to cell enlargement and preparation for cell division .
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PMC6034753
Apoptin protein expression in U2OS cells was induced by doxycycline (1 μg/mL), and U2OS-apoptin lysate was used for GST-pull down assay.
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PMC11787355
The later identified reactive TCR is highlighted.
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PMC10547921
The cyclic dinucleotides (CDNs) (93) have been extensively studied as natural ligands of STING proteins (Fig. 16A).
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PMC9429973
Innate immunity CD56+NK and CD3+CD8+cytotoxic cells were first to reconstitute.
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PMC9429973
Fourteen patients (31%) had a prior diagnosis of breast cancer.
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PMC11509224
A kalihinol diterpene, 10-epi-kalihinol X (17, Figure 3), was obtained from the Hainan sponge Acanthella sp. .
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PMC11095939
The knockdown efficacy of Nr1h3 and Rara was verified by qPCR.
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PMC9261184
Note that no other study explicitly modeled generator engine emissions, only the main propulsion or an aggregate (e.g., based on the total fuel consumption as per ref).
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PMC10969097
The ultrasound temperature was kept between 25 °C and 37 °C, and the frequency was 20 kHz.
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PMC4355729
Compared with normal kidney tissue group, the mRNA expression of PIK3R1 was significantly decreased in RCC group (n = 18) (Fig. 1b).
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PMC9596868
PA-1 cells were treated with 1µM MST-312, 10 µM quercetin and their combination for 24 h. Control group was treated with DMSO.
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PMC10212663
The data used to explore expression and prognosis were obtained from The Cancer Genome Atlas, Genotype‐Tissue Expression databases, and from our hospital.
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PMC11648299
The patients have provided written informed consent for the publication of their photos The national cohort included 770 patients (461 [60%] females and 309 [40%] males) with at least one diagnosis of DD in the time period of 2001–2020.
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PMC11739504
Quantification of the subcellular localization of Kat2b.
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PMC11656380
Therefore, we also conducted cytotoxicity assays using concentrations greater than 100 μM on glioblastoma U-251MG cells.
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PMC9622879
Moreover, individual RES energy can be used in many manners: for home loads, for selling to outside the community, or for charging to the individual ESS of a home if this home has its own ESS.
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PMC8875242
We initially performed bidirectional transport experiments using [H]-digoxin alone, for which the efflux ratio (rPapp) was 9.53 ± 2.22.
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PMC10734950
The cells were rocked gently at 4°C for 1 h. The total protein extracts were then transferred to microcentrifuge tubes and centrifuged for 1200 RPM for 10 min.
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PMC11352311
We docked esculin with seven core target proteins after dehydrogenating and hydrogenating the protein structures and hydrogenating the esculin structure.
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PMC9429973
Systemic mastocytosis (SM) typically occurs in adults with KIT D816V mutation (3).
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PMC10253973
In addition, examples of the Ru(II)/(III) complex compounds for which clinical trials were undertaken are also given.
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PMC6600592
Cyclohexyl 4-oxo-4-phenylbutanoate (3A) Colorless liquid, yield 91.6%.
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PMC11703992
To explore the effect of DDIT4 on Jurkat cells, we not only observed changes in the genetically modified Jurkat cells, but also assessed alterations in the activity following PMA induction as part of the experimental system.
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PMC8170755
It has recently been noted that concomitant inhibition of CD44v6 and matrix metalloproteinase-9 (MMP-9) lowers migration of neoplastic cells (12).
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PMC11291490
All experimental procedures involving animals received approval from the Institutional Animal Care and Use Committee of Sichuan Agricultural University, China, under Permit Number SYXK(川)2019-187.
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PMC4443654
The region chr5:158–159 Mb, which occupies the open A compartment in GM12878 cells, is shown as an example (top five regions for each cell type are shown in Additional file 1: Figure S10).
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PMC11126803
Vasculogenic mimicry, referred to as VM, is closely related to clinical stage, pathological grade, and tumor invasion and metastasis (8, 9) and plays a role similar to vascular function (10).
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PMC6160470
Of note, crown-ethers activate P-gp ATPase and specifically sensitise MDR cells to paclitaxel at low and non-toxic concentrations.
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PMC10976516
Significant tumor clearance occurred, loaded MSCs homing into the CMT64 tumor followed by an invasion of the tumor bed by a high number of CD8+ and CD4+ cells.
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PMC9429973
Treating this pt population on a clinical trial is feasible and can allow pts to achieve remission and move on to effective post-remission therapy.
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PMC6650823
Highlighted by Michael Gütschow In contrast to disruptors of a protein–protein interaction (PPI), low-molecular-weight stabilizers of PPIs are relatively scarce .
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PMC8170755
The culture medium was refreshed every 3–4 days.
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PMC11775197
An excellent article confirms that overcoming TME can increase the sensitivity of Chimeric antigen receptor (CAR) T cells .
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PMC11763764
We first validated the basal expression of SORL1 protein in OVCAR8 and KRCH31 cells (Figure 1C).
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PMC11700165
Subsequently, cells were fractionated into nuclear and cytoplasmic fractions.
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PMC10907726
This inhibitory effect of DATS can be reversed by adding 3-MA, indicating the reactivation of the EGFR/PI3K/AKT/mTOR signaling pathway partly increased migratory and invasiveness, but decreased expression of autophagy-related markers.
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PMC11400680
A focal loss that mainly focuses on the training of hard samples was integrated to improve the performance of Mask-RCNN (21).
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PMC11519583
In addition, it has recently been shown that Ror1 and Ror2 are selectively expressed in adult stem cells, even in intact tissues, including hair follicles, dental pulp, and skeletal muscles [9–11].
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PMC9429973
GAS5 and miR-222 expression levels were analysed using Real-Time PCR.
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PMC11754432
siRNA-mediated silencing of ALOX15B increased CCL2 expression and secretion.
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PMC11633763
However, changes in USP22 expression did not significantly affect β‐catenin mRNA expression (Figure 6B,C).
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PMC9268620
Nordamnacanthal and damnacanthal from the roots of Morinda elliptica imparted a cell growth inhibitory response in CEM-SS cells via the induction of apoptosis and necrosis.
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PMC9429973
After a median observation time of 451 days (range 1-1016), CTCAE grade ≥3 AEs were reported in 57% (n=57) of all patients, 61% (n=20) in TP53 aberrant patients and 64% (n=27) in the TP53 wt patients.
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PMC11476106
Cluster area and circularity were parameters provided by QuPath.
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PMC9429973
Image: Summary/Conclusion: Tafasitamab serum concentration reached and maintained a therapeutic dose level in this first-line regimen and declined in line with known tafasitamab half-life (~16 days) after treatment completion; tafasitamab levels were comparable between the two treatment arms.
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PMC10734950
The HRP-Anti-Rabbit IgG was pipetted from each well and washed in the same manner.
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PMC10958426
Accumulation curve of CV of gene expression level in epithelial cells and epithelial subtypes compared with same genes in cancer cells in all patients.
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PMC11257203
The results of this study might help to a better understanding of the mechanism of indomethacin-induced genotoxicity and also provide a safe solution to attenuate indomethacin side effects.
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PMC7171147
A204, CAFs, ES2, and Lenti-X 293T cell lines were cultured in DMEM (Gibco Life Technologies) supplemented with 10% FBS (Sigma-Aldrich) and 1× penicillin/streptomycin (Gibco Life Technologies).
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PMC9031474
Drimane and coloratane sesquiterpenoids are present in several plants, microorganisms, and marine life.
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PMC9275501
In tumor cells, the hydrogel coating could be lysed and released by glutathione.
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PMC11753541
The temperature attained in the autoclaved box was measured with a digital thermometer sensor wired for room temperature [Figure 1].
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PMC11770199
Therefore, cell–cell fusion as a cell-killing mechanism might develop a novel cytotherapy aimed at improving the efficacy against solid tumors.
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PMC3681794
siRNAs targeted to HIF-1α and non-targeting (NT) control siRNA were from Dharmacon SMARTpool (Thermo-Scientific L-004018-00 and D-001810-01-20).
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PMC9429973
The abundance of Bacteroidota was higher in fecal samples collected from patients with stage Binet A in comparison to stage Binet B (p=0.051) and C (p=0.009).
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PMC11727145
It contains essential components that collectively promote the formation of multilayered, functional epidermal structures .
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PMC8996378
In summary, many diterpenic structures showed MDR-reversal potential.
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PMC9250505
The treatment regimen is summarized in Supplementary Fig. 8A.
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PMC11766332
These modifications are important for glycan’s final structure and function.
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PMC11531744
The transfection efficiency of sh-GBP1P1 in the W038 cell line detected by q-PCR. (
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PMC8270637
TGF-β1, an inhibitory cytokine in the tumor microenvironment, also inhibits the function of T lymphocytes.
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PMC9388315
In this method, normal cells are seen uniformly and have a normal nucleus, whereas apoptotic cells' nuclei have dense Chromatin and nuclear fragmentation and seem irregular appearance, also they seem as bright spots.
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PMC10965315
It has been reported that harmaline can suppress the proliferative activity of several cancerous cells, including esophageal squamous cell carcinoma (ESCC) (Zhang et al., 2021), myeloma (Boeira et al., 2001), as well as lung (Roy et al., 2020), breast (Rashidi et al., 2022), liver (Xu et al., 2018), and gastric cancers (Wang et al., 2015).
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PMC9954564
We then performed multivariate analyses considering several markers simultaneously using the machine learning method MDR to screen for potential gene–gene interactions among the 213 variants from HLA-G and LILRB1/2.
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PMC11711345
The residual solvent was removed under a vacuum and a freeze dryer.
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PMC6267596
Here, we provide evidence that DIAP cells can re-enter the cell cycle and escape cell death during anti-DLBCL treatment.
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PMC10759659
c GSEA identified that the epithelial-mesenchymal transition (EMT) pathway was highly enriched in the ARID1A-deficient group compared with the ARID1A normal functioning group.
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PMC7887261
f Examples of flow cytometry dot plots showing DNA-damage positive subpopulation.
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PMC11314247
HO-AAVPA increased the S phase in MCF-7 cells and reduced the G2/M phase in MCF-7 and MDA-MB-231 cells.
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PMC9429973
Cytogenetic and molecular analysis for RUNX1-RUNX1T1, CBFβ/MYH11, FLT3-ITD, NPM1 were routinely performed.
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PMC3274243
The Oncoprobe biosensor unit is comprised of an eight well culture assembly featuring a re-usable acrylic culture vessel with disposable ceramic probe attached to an analytical monitor.
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PMC10547921
Tumor-specific antigens are very limited, especially in solid tumors.
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