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PMC11792090
Experimental data were analyzed and plotted using GraphPad Prism 8.0 software and are presented as means ± SD.
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PMC10870498
However, the prognosis of ATC patients is poor and nearly incurable with a median survival of only six months .
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PMC10443665
The obtained cDNA was preserved at -70 °C for future steps.
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PMC9424261
All three genes were all upregulated after CA treatment, further confirming the high-throughput omics results (Fig. 2B–D).
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PMC11805741
B Molecular docking of obatoclax and BCL-2 Table 1Analysis of the HPLC chromatogram of the extracted carotenoids showing retention time (TR) and maximum absorption wavelength (λmax) of the five separated fractions.
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PMC10093184
Similar to that described above, the migration potential of COS4288 was superior to that of COS3600B, COS3600 and COS4074 cells, as documented by quantitative analysis (Figure 4B) and a representative picture of stained inserts (Figure 5).
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PMC9250505
The primary and secondary anti-rabbit and anti-mouse horseradish peroxidase (HRP)-conjugated antibodies used were tabulated in Supplementary Table 9.
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PMC11391695
Fig. 5Synthesis and identification of pcDNA/PEI/NPs@M nanocomposites.
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PMC9429973
In a humanized mouse model, PFKFB3-overexpressing T cells aggravated aGvHD, as characterized by high aGvHD clinical scores, pathological scores and rapid lethality.
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PMC11767817
Compound 2a was added to the cells at concentrations of 2 µM, 4 µM, and 8 µM, while compound 2a-B was used at concentrations of 1 µM, 2 µM, and 4 µM. The cells were incubated with the tested compounds for 4, 8, and 20 h. Following incubation, the cells were harvested using Trypsin-EDTA and washed twice with cold DPBS.
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PMC11599565
This regulatory transcription factor plays a key role in the development of the nervous system and embryogenesis of the renal/upper urinary tract, Müllerian duct, and the thyroid.
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PMC8557138
Living biobanks of patient-derived organoids are being developed.
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PMC11534377
Five human NSCLC cell lines A549, A549-Luc2, SK-MES-1, H1792 and H522 were utilized in this study and were purchased from the American Type Culture Collection (ATCC).
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PMC11267830
Following a 48-h incubation period, puromycin (1 μg/ml) was added for selection purposes, with the incubation period extended to 72 h. Two million cancer cells were intravenously injected into NSG mice (n = 6/group), and imaging was performed every 10 days.
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PMC9429973
STR-profiling using COrDIS Plus panel (Gordiz LLC, Russia) of isolated DNA samples (21 plasma circulating cfDNA samples, 11 CD138+ DNA samples of bone marrow cells, 6 plasmacytoma DNA samples) was performed.
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PMC10123657
In the resulting tables, the gene names assigned to human proteins and peptides were written in upper case letters, and those of mouse, in lower case letters; this allowed differentiation of the species to which a particular protein or peptide belonged.
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PMC11357960
A–C) The relative mRNA expression of SUMO1 (A), SUMO3 (B) and UBE2I (C) in PBMC from responders (n=53) and non-responders (n=52).
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PMC11291490
ns > 0.05, P < 0.05, P < 0.01, P < 0.001.
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PMC11539788
A CHX assay was conducted to analyse the protein half-life and protein stability.
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PMC7338939
Results showed that Notch inhibition in a short time dramatically reduced the colony and sphere formation abilities in both adherent and spheroid cells (Figure 2A).
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PMC11803149
B16-OVA cells cultured alone for 3 days were also analyzed for comparison. (
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PMC10631132
A lower cell density of mononuclear cells was observed for the PBMC-derived cell line (Fig. 6D) in comparison with the fibroblast-derived cell line (Fig. 6G and H).
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PMC9780037
The impact of cyt c point mutations, post-translational modifications, and redox state in its proapoptotic function. (
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PMC11295144
The α2β2γ2-GABAAR stable cell line was described previously (Brown et al., 2014) and in Supplementary Figure S1.
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PMC11792090
The top five scFvs selected from Figure 1C were then incorporated into CD70 CAR-T cells, and the short-term tumor-killing ability of these CD70 CAR-T cells was assessed by co-culturing them with 786-0 cells for 6 hours.
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PMC10809689
Densitometry of protein bands was performed by using the ImageJ Version 1.44 software and gel analyzer Version 2010a software (NIH, USA) .
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PMC10761571
Fig. 1 FT-IR analysis of Fe3O4@Glu-Gingerol NPs.
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PMC10998613
For more accurate measurements of protein diffusion and interactions, higher-resolution microscopy-based methods, such as SMT, FCS, and fluorescence cross-correlation spectroscopy (FCCS) can be employed.
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PMC9429973
Increasing of ECOG and HCT-CI for one point decrease probability of develope thrombosis for 28% and 21%; 4.
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PMC11394730
The authors concluded that autophagy-mediated cell death was triggered in ovarian cancer cells by the energy deprivation state generated by RV .
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PMC10671321
At the neuromuscular junction, the main AChE molecular form is called A12, where A stands for asymmetric, and 12 stands for the three tetramers of AChE interacting with the three strands of ColQ. Besides the PRAD, ColQ contains two other domains, a collagen domain with the glycine-X-Y repeated motif characteristic of collagens and a C-terminus domain (CTD).
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PMC11752740
The analysis of combination therapy indicated a synergistic effect between the two treatments after both 24- and 48-hours of exposure.
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PMC10988555
Calculated for C37H29CoF6N3O6PS2 (879.67 g/mol): C, 50.52; H, 3.32; N, 4.78; S, 7.29.
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PMC9275501
Nanosuspensions are nanoscale, heterogeneous aqueous dispersions of insoluble drug particles stabilized by surfactants (Jacob et al., 2020).
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PMC6799808
Mechanistically, GLPT downregulated the phosphorylation and protein levels of insulin-like growth factor 1 receptor (IGFR) and phosphoinositide 3-kinase (PI3K) as well as the protein level of RAS homolog enriched in brain (Rheb).
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PMC10698968
F Clonogenic potential in 2D: 100 cells/well were seeded in a 6-well plate and Methylene blue stained colonies were counted after 7 (143B) or 14 days (MF-R 3).
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PMC9429973
Patients taking immunosuppressive agents have been considered potentially at risk for severe acute respiratory syndrome coronavirus 2 infection.
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PMC11723947
a Experimental model.
[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "a", "Experimental", "model", "." ] } ]
PMC10454535
RES had the highest IC50 value at 24 and 48 h and a value similar to those of PIN and PIC at 72 h. PIC had the lowest IC50 value at 24 and 48 h. PIN showed IC50 values similar to RES at each time point.
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PMC9429973
H. Cai, T. Liu, H. Cai, M. Duan, J. Li, D. Zhou, X. Cao Department of Hematology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Background: Langerhans cell histiocytosis (LCH) is a rare, clonal disorder derived from CD1a-positive and CD207-positive immature myeloid dendritic cells.
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PMC8873393
Nuclear DNA was counterstained with DAPI.
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PMC11653533
At the same time, they increase the enzyme activity by 1.46, 1.13, and 1.27 fold, respectively (Rahman et al., 1994).
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PMC11267036
The BALB/c nude mice were randomly assigned to control and DHM groups (n = 6).
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PMC11711871
Briefly, 20–80 µg of protein was loaded and separated on a SDS‒PAGE gel (10% gradient gel for Western blot analysis for sEH and 7.5% gel for Western blot analyses for eNOS/NOS and PKG Bio-Rad Laboratories).
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PMC8658661
However, the article describing the characteristics of the THLE-2 and THLE-3 cell lines mentioned their similarity with human hepatocytes .
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PMC11588085
Downregulation of XIST in ovarian tumors is associated with reduced expression of upstream activators JPX and FTX.
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PMC11470381
Wash the dish five times with 1× PBS (200 µL, 5 min each).
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PMC11093197
Cyclin D‐CDK4/6 and cyclin E‐CDK2 complexes drive cell cycle progression.
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PMC11764090
rosette vernalization has been shown to boost seed germination across various ecotypes (Table 1).
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PMC11055323
n = 5 condensates.
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PMC11782780
Total RNA was isolated from cultured cells by TRIzol (Invitrogen), and cDNA was synthesized by PrimeScript RT reagent Kit with gDNA Eraser (Takara, Kusatsu, Japan).
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PMC7351993
The entire process is operated in a fully automated and real-time manner.
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PMC6901583
d GIST882 control vector cells or BRD4 cells were subcutaneously injected into Balb/c nude mice.
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PMC11228511
The antibodies and concentrations are listed in SI Appendix, Table S1.
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PMC11592837
Of note, Jurkat cells principally exhibited higher levels of n-cfDNA (>10 fold) than PBMCs, which may have reduced the accuracy of the qPCR results at later time points.
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PMC8751435
Furthermore, caspase‐3/GSDME pyroptosis and caspase‐3/PARP apoptosis are reported to be simultaneously induced by chemotherapy drug in A549 (Zhang et al., 2019).
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PMC10243817
We therefore prepared constructs with A-to-C mutations in these 4 sites, including 4106 to 4114 sites (MUT1), 4385 to 4405 sites (MUT2), 5416 to 5422 sites (MUT3), and 5558 to 5564 sites (MUT4) (Figure 3E).
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PMC9910796
Nucleus was stained with Hoechst 33258 (blue).
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PMC11661024
The obtained cDNA was synthesized using the Revert Aid First Strand cDNA Synthesis Kit (Norgene Biotech, Canada) according to the manufacturer’s protocols.
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PMC9429973
MF patients with high plasmatic TAC display inferior survival and multivariate analysis demonstrated that increased TAC activity might represent a novel prognostic biomarker independent from DIPSS classification.
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PMC11640555
The exchange of molecules and information via ECs plays a critical role in GBM progression and tumor angiogenesis, which may involve a reprogramming of ECs turnover and stability of BTB.
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PMC10197932
Jurkat cells show soon (0 hours after US treatment) about 65% of mortality (Figure 2A) but 35% of cells remain still alive (2T), and no alive cells were found after 5T (100 s) US treatment.
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PMC9429973
Well known founder variants (FV) in specific populations were labeled as PPGV-FVs.
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PMC10674574
The pharmaceutical requirements define only the acceptance criteria for the validation of the Caco-2 cell line and do not specify the protocol for its implementation.
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PMC9985266
Both inflammation and oxidative stress are crucial in inducing the progression of PF, and inhibiting inflammation and oxidative stress can reduce BLM-induced PF .
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PMC11502962
However, the reason for the increase in tumor-infiltrating M2 macrophages in the high-risk GIST was not clear.
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PMC11754432
Next, nuclear protein expression of SREBP2 was detected by confocal microscopy.
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PMC9429973
Cytogenetic analysis was performed on lymphocytes and bone marrow cells after short-term culture (48 hours).
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PMC11495567
To determine the mechanism of PCAIs-induced cell death, the FITC Annexin V/ Dead Cell Apoptosis Kit was used.
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PMC9429973
HSCT was recommended in case of severe infections, persistent severe neutropenia, progression with additional cytogenetic aberrations or increase in blasts (MDS-EB), or persistence of monosomy 7 beyond the age of 5 years.
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PMC3765139
CD133+ and unsorted D10 cells induced tumor formation in vivo.
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PMC11476264
Patient sample data were downloaded from the TCGA database and grouped according to high and low FBXO11 expression.
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PMC11534377
The top left panel denotes the untreated control group, reflecting the baseline invasive behavior of the cells.
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PMC9429973
Among studied patients; 29 (82.9%) had hepatomegaly at diagnosis with hepatic reactivation in 51.4%.
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PMC11637276
For antibody staining, cells were blocked in 1% (w/v) bovine serum albumin (BSA) for 1 h at room temperature.
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PMC10976516
The need for new or better therapies for lung cancer is urgent and one way to alleviate this necessity could be the application of oncolytic virotherapy.
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PMC11467964
The Spearman analysis was performed to determine correlations between variables.
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PMC11621493
Maximum intensity projection shows the highest pixel intensities from stacked images indicating that the enzyme shows primarily cytosolic localization.
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PMC9964635
Analysis calculated for C24H30N4OS, C, 68.21; H, 7.16; N, 13.26; S, 7.59%.
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PMC11723947
Deduplicated and filtered alignments were given to HMMRATAC v.1.2.10 for peak detection.
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PMC9918897
A total of 2 mL of each of the pooled plasma samples was measured into 10 mL volumetric flasks and brought to the mark with distilled water, thus creating a fivefold dilution.
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PMC11190538
Phosphatidylcholine expands when in contact with water, forming a hydrogel layer.
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PMC11019355
Narrowing in on one putative trans driver (ETS1), they identified and experimentally validated cis-regulatory changes associated with increased expression of the TF in human cells.
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PMC9429973
Patients with severe congenital neutropenia are prone to recurrent gingivitis, mouth and rectal ulcerations, and often life-threatening bacterial infections.
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PMC9954564
This hypothesis is further supported by frequent HLA-G association with other autoimmune diseases, such as lupus erythematosus systemic , Crohn’s disease , multiple sclerosis , rheumatoid arthritis , and pemphigus vulgaris , along with HLA-G ectopic expression in skin pathologies .
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PMC11522251
The colony formation area was evaluated and analyzed using ImageJ software. ****
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PMC4659567
The cytotoxicity data were received from three independent experiments (each conducted in triplicate) using cells from three consecutive passages.
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PMC11155445
Synthesized compound crystallized in the monoclinic system adopting C2/c space group.
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PMC11126803
Interestingly, when we regulate the expression of ERβ in cells, only ZEB1 is highly consistent with the former trend, which gives us reason to consider whether ZEB1 is the downstream target gene of ERβ in regulating VM formation in RCC (Fig. 4A).
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PMC9429973
Prevalence of PH was calculated as a proportion and CI are exact using Clopper-Pearson method.
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PMC11544122
We next examined the recruitment of SNX9 to the CXCR4 phospho-cluster variants by BRET.
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PMC9429973
Results: Patients with significantly elevated baseline levels of terminal complement complexes had more often undergone splenectomy (p = .08), exhibited more often an inadequate platelet response (p = .04) and were exclusively subjected to rescue therapy with intravenous immunoglobulin (p = .02) during the study period.
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PMC11754094
Therefore, we predicted that UGI-lacking BEs generate DSBs and consequently, large deletions during the BER process through a nick on each strand—one by nCas9 (D10A) and another by AP lyase.
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PMC3035438
The loading of non-diluted culture supernatant (first blot) leads to deformed band because of the over-loading of serum proteins.
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PMC11529598
Several recent studies have indicated that dysregulated miRNAs expression is also involved in pathogenesis of glioblastomas .
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PMC11543885
The remaining lysate can either be frozen at −80°C for future use or immediately proceed to streptavidin pull-down.
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PMC11727306
Future work might explore whether the in vitro effects of abrin can be replicated in animal models.
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PMC11087766
mRNA must be exported, while many proteins for DNA replication and transcription must be imported.
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PMC11300639
By regulating key mechanisms such as the cell cycle, transcription factors, and cell apoptosis, CDK4/6 participates in the regulation of tumor occurrence and development.
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PMC10452486
Cell surface HLA-I molecules (Face-1) consist of a polypeptide heavy chain (HC) with two groove domains (G domain) and one constant domain (C-domain) as well as a light chain, B2-microglobulin (B2m).
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