OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11596967	The ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) assay was performed following the modified protocol by Re et al. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ABTS", "(", "2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic", "acid", ")", ")", "assay", "was", "performed", "following", "the", "modified", "protocol", "by", "Re", "et", "al.", "." ] } ]
PMC11248911	All experiments were conducted in triplicate (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "conducted", "in", "triplicate", "(", "n", "=", "3", ")", "." ] } ]
PMC11546117	Within the OAT subfamily, we showed expression, even if very low, of OAT1 (SLC22A6), OAT2 (SLC22A7), and OAT3 (SCL22A8), while these genes were below the detection level in non-lactating cells according to Alcorn et al. (2022) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "the", "OAT", "subfamily", ",", "we", "showed", "expression", ",", "even", "if", "very", "low", ",", "of", "OAT1", "(", "SLC22A6", ")", ",", "OAT2", "(", "SLC22A7", ")", ",", "and", "OAT3", "(", "SCL22A8", ")", ",", "while", "these", "genes", "were", "below", "the", "detection", "level", "in", "non-lactating", "cells", "according", "to", "Alcorn", "et", "al.", "(", "2022", ")", "." ] } ]
PMC9577200	Then, 2 ml of LB medium was added to the mixture in 5 ml tubes, and the tubes were kept on a rotary shaker at 120 rpm and 30°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "2", "ml", "of", "LB", "medium", "was", "added", "to", "the", "mixture", "in", "5", "ml", "tubes", ",", "and", "the", "tubes", "were", "kept", "on", "a", "rotary", "shaker", "at", "120", "rpm", "and", "30", "°", "C", "." ] } ]
PMC11592837	DOX was reported to generate reactive oxygen species, lipid peroxidation, membrane damage and mitochondrial degeneration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DOX", "was", "reported", "to", "generate", "reactive", "oxygen", "species", ",", "lipid", "peroxidation", ",", "membrane", "damage", "and", "mitochondrial", "degeneration", "." ] } ]
PMC3203927	An interaction with a material which yields cells that emulate in vivo conditions would be most desirable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "interaction", "with", "a", "material", "which", "yields", "cells", "that", "emulate", "in", "vivo", "conditions", "would", "be", "most", "desirable", "." ] } ]
PMC5363531	Genomic DNA (gDNA) was extracted using Wizard Genomic DNA Purification Kit (Promega) following the manufacturer's instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genomic", "DNA", "(", "gDNA", ")", "was", "extracted", "using", "Wizard", "Genomic", "DNA", "Purification", "Kit", "(", "Promega", ")", "following", "the", "manufacturer", "'s", "instructions", "." ] } ]
PMC8922418	However, the difficulty and complexity of pegRNA design for PE are much higher than those of sgRNA for BE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "difficulty", "and", "complexity", "of", "pegRNA", "design", "for", "PE", "are", "much", "higher", "than", "those", "of", "sgRNA", "for", "BE", "." ] } ]
PMC9429973	These data indicate that MRK-560 synergizes with dexamethasone via downregulation of HES-1 (downstream of NOTCH1), resulting in enhanced glucocorticoid signaling with higher BIM expression levels and apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "indicate", "that", "MRK-560", "synergizes", "with", "dexamethasone", "via", "downregulation", "of", "HES-1", "(", "downstream", "of", "NOTCH1", ")", ",", "resulting", "in", "enhanced", "glucocorticoid", "signaling", "with", "higher", "BIM", "expression", "levels", "and", "apoptosis", "." ] } ]
PMC6901583	This work explored whether BRD4 was associated with this pathway and reported that increased levels of BRD4 led to the in vitro and in vivo formation of HUVEC tubes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "work", "explored", "whether", "BRD4", "was", "associated", "with", "this", "pathway", "and", "reported", "that", "increased", "levels", "of", "BRD4", "led", "to", "the", "in", "vitro", "and", "in", "vivo", "formation", "of", "HUVEC", "tubes", "." ] } ]
PMC7171147	There are two possible explanations for co-activation of FAO and fatty acid synthesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "are", "two", "possible", "explanations", "for", "co-activation", "of", "FAO", "and", "fatty", "acid", "synthesis", "." ] } ]
PMC9096373	Specific-pathogen-free (SPF) feeding was carried out at the medical laboratory animal center.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specific-pathogen-free", "(", "SPF", ")", "feeding", "was", "carried", "out", "at", "the", "medical", "laboratory", "animal", "center", "." ] } ]
PMC11347429	Pathway analysis for DEGs between infected patients and healthy controls agreed with other studies of influenza-infected patients regarding upregulation of common virus-host defense pathways ( Figure 2 ; Data file 6 ) (17–33) and other respiratory virus infections (33).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathway", "analysis", "for", "DEGs", "between", "infected", "patients", "and", "healthy", "controls", "agreed", "with", "other", "studies", "of", "influenza-infected", "patients", "regarding", "upregulation", "of", "common", "virus-host", "defense", "pathways", "(", "Figure", "2", ";", "Data", "file", "6", ")", "(", "17–33", ")", "and", "other", "respiratory", "virus", "infections", "(", "33", ")", "." ] } ]
PMC9822769	Very recently, the role of volume-regulated anion channels VRACs, best known for their role in cell-volume homeostasis, has been postulated in the transport of cisplatin and its Pt(II) congeners .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Very", "recently", ",", "the", "role", "of", "volume-regulated", "anion", "channels", "VRACs", ",", "best", "known", "for", "their", "role", "in", "cell-volume", "homeostasis", ",", "has", "been", "postulated", "in", "the", "transport", "of", "cisplatin", "and", "its", "Pt(II", ")", "congeners", "." ] } ]
PMC11228511	To test this hypothesis, we used doxycycline (Dox)-inducible vectors to create SMCs that express prelamin A (which is processed to mature lamin A) as well as SMCs that express progerin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "test", "this", "hypothesis", ",", "we", "used", "doxycycline", "(Dox)-inducible", "vectors", "to", "create", "SMCs", "that", "express", "prelamin", "A", "(", "which", "is", "processed", "to", "mature", "lamin", "A", ")", "as", "well", "as", "SMCs", "that", "express", "progerin", "." ] } ]
PMC11265931	Subsequently, 100 μL of prepared Streptavidin solution was added to each labeled well and incubated for 45 min at room temperature with gentle shaking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "100", "μL", "of", "prepared", "Streptavidin", "solution", "was", "added", "to", "each", "labeled", "well", "and", "incubated", "for", "45", "min", "at", "room", "temperature", "with", "gentle", "shaking", "." ] } ]
PMC7053076	Various members of the NF-κB family are constitutively activated in many cancers via one of the two pathways: the canonical pathway involving RelA, NF-κB1 p50 and c-Rel and the non-canonical pathway engaging RelB and NF-κB2 p52.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Various", "members", "of", "the", "NF-κB", "family", "are", "constitutively", "activated", "in", "many", "cancers", "via", "one", "of", "the", "two", "pathways", ":", "the", "canonical", "pathway", "involving", "RelA", ",", "NF-κB1", "p50", "and", "c-Rel", "and", "the", "non-canonical", "pathway", "engaging", "RelB", "and", "NF-κB2", "p52", "." ] } ]
PMC11792766	Data are shown as mean + standard error of the mean (SEM) (n = 9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "+", "standard", "error", "of", "the", "mean", "(", "SEM", ")", "(", "n", "=", "9", ")", "." ] } ]
PMC6182045	Affinity purified polyclonal goat antibodies, raised against an equimolar mixture of purified gp120s from clade B (MN), clade C (CN97001), and clade E (TH023) gp120s, was used as a positive control for the FIA binding assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Affinity", "purified", "polyclonal", "goat", "antibodies", ",", "raised", "against", "an", "equimolar", "mixture", "of", "purified", "gp120s", "from", "clade", "B", "(", "MN", ")", ",", "clade", "C", "(", "CN97001", ")", ",", "and", "clade", "E", "(", "TH023", ")", "gp120s", ",", "was", "used", "as", "a", "positive", "control", "for", "the", "FIA", "binding", "assays", "." ] } ]
PMC11388384	SCUBE1 expanded SHH signaling gradients in a dose-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SCUBE1", "expanded", "SHH", "signaling", "gradients", "in", "a", "dose-dependent", "manner", "." ] } ]
PMC11335267	Receptors for leptin (LepR), ghrelin (GHSR), adenosine (AdRA1), melanocortin (MC3R and MC4R), glucagon-like peptide 1 (GLP1R) and erythropoietin (EpoR) were tested (n = 8 per genotype except for EpoR, 5 wild type and 6 Alx3-deficient mice). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Receptors", "for", "leptin", "(", "LepR", ")", ",", "ghrelin", "(", "GHSR", ")", ",", "adenosine", "(", "AdRA1", ")", ",", "melanocortin", "(", "MC3R", "and", "MC4R", ")", ",", "glucagon-like", "peptide", "1", "(", "GLP1R", ")", "and", "erythropoietin", "(", "EpoR", ")", "were", "tested", "(", "n", "=", "8", "per", "genotype", "except", "for", "EpoR", ",", "5", "wild", "type", "and", "6", "Alx3-deficient", "mice", ")", ".", "(" ] } ]
PMC9429973	No changes in IgG levels were observed in patients treated with placebo during that time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "changes", "in", "IgG", "levels", "were", "observed", "in", "patients", "treated", "with", "placebo", "during", "that", "time", "." ] } ]
PMC11434983	The cytotoxicity of the new compound is also within the range of the cytotoxic activity reported for the first generation EGFR TKIs currently used in clinical practice since, in the literature, the IC50 values for gefitinib, erlotinib, lapatinib, using the A431 cell line, range from 1.33 to 4.80 μΜ .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cytotoxicity", "of", "the", "new", "compound", "is", "also", "within", "the", "range", "of", "the", "cytotoxic", "activity", "reported", "for", "the", "first", "generation", "EGFR", "TKIs", "currently", "used", "in", "clinical", "practice", "since", ",", "in", "the", "literature", ",", "the", "IC50", "values", "for", "gefitinib", ",", "erlotinib", ",", "lapatinib", ",", "using", "the", "A431", "cell", "line", ",", "range", "from", "1.33", "to", "4.80", "μΜ", "." ] } ]
PMC7189327	Additionally, CYFIP2, HOXB5, PTPN3, MARCKSL, CDC20, and PTCH1 had superior diagnostic values for BCC prediction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "CYFIP2", ",", "HOXB5", ",", "PTPN3", ",", "MARCKSL", ",", "CDC20", ",", "and", "PTCH1", "had", "superior", "diagnostic", "values", "for", "BCC", "prediction", "." ] } ]
PMC11763764	After washing with 1× wash buffer A twice, the ligation mix was incubated for 30 min at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "washing", "with", "1", "×", "wash", "buffer", "A", "twice", ",", "the", "ligation", "mix", "was", "incubated", "for", "30", "min", "at", "37", "°", "C", "." ] } ]
PMC10006224	We next defined “gained” loops as those called only in NIPBL KD replicates and “lost” loops as those called only in wild type replicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next", "defined", "“", "gained", "”", "loops", "as", "those", "called", "only", "in", "NIPBL", "KD", "replicates", "and", "“", "lost", "”", "loops", "as", "those", "called", "only", "in", "wild", "type", "replicates", "." ] } ]
PMC11047729	Fatty acids C18–C22 directly affect telomerase activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fatty", "acids", "C18–C22", "directly", "affect", "telomerase", "activity", "." ] } ]
PMC11640247	Biochemical and cell biological analyses indicated that RAC3-R66W functions as an activated variant in vitro (Figure 1 and Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Biochemical", "and", "cell", "biological", "analyses", "indicated", "that", "RAC3-R66W", "functions", "as", "an", "activated", "variant", "in", "vitro", "(", "Figure", "1", "and", "Figure", "2", ")", "." ] } ]
PMC9872547	Free curcumin with a higher concentration (50 μM) could induce apoptosis in 25.9% of cells (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Free", "curcumin", "with", "a", "higher", "concentration", "(", "50", "μM", ")", "could", "induce", "apoptosis", "in", "25.9", "%", "of", "cells", "(", "Figure", "2", ")", "." ] } ]
PMC11711347	Cisplatin functions as a cytostatic agent by inhibiting DNA synthesis, leading to cancer cell death .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cisplatin", "functions", "as", "a", "cytostatic", "agent", "by", "inhibiting", "DNA", "synthesis", ",", "leading", "to", "cancer", "cell", "death", "." ] } ]
PMC9429973	In 2014, ibrutinib was approved by the European Medicines Agency and made available to CLL pts in Germany.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "2014", ",", "ibrutinib", "was", "approved", "by", "the", "European", "Medicines", "Agency", "and", "made", "available", "to", "CLL", "pts", "in", "Germany", "." ] } ]
PMC8633974	After 72 hours following electroporation, ACH2 cells were stimulated with TNF-α (15 ng/mL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "72", "hours", "following", "electroporation", ",", "ACH2", "cells", "were", "stimulated", "with", "TNF-α", "(", "15", "ng/mL", ")", "." ] } ]
PMC11752740	For this study, we used fresh Pistacia vera var.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", "study", ",", "we", "used", "fresh", "Pistacia", "vera", "var", "." ] } ]
PMC11806613	Quantification of protein expressions are shown on top.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantification", "of", "protein", "expressions", "are", "shown", "on", "top", "." ] } ]
PMC6892818	Lysate from effector (3T3CD40L) cells alone (20 µg protein/lane) served as negative control (NC) and confirmed the human-protein specificity of the anti-TRAF1 (a), anti-TRAF2 (b) and anti-TRAF3 (c) antibodies.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lysate", "from", "effector", "(", "3T3CD40L", ")", "cells", "alone", "(", "20", "µg", "protein/lane", ")", "served", "as", "negative", "control", "(", "NC", ")", "and", "confirmed", "the", "human-protein", "specificity", "of", "the", "anti-TRAF1", "(", "a", ")", ",", "anti-TRAF2", "(", "b", ")", "and", "anti-TRAF3", "(", "c", ")", "antibodies", "." ] } ]
PMC11748335	Hence, we downloaded TE regions from the UCSC database and obtained DMV regions from a previous study .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "we", "downloaded", "TE", "regions", "from", "the", "UCSC", "database", "and", "obtained", "DMV", "regions", "from", "a", "previous", "study", "." ] } ]
PMC11449273	Conversely, plakoglobin has a p53-dependent effect (whether wild-type or mutant) on S100A4 expression as evidenced by the decreased trend of S100A4 expression when plakoglobin was co-expressed in either H1299- p53- (WT, 175, or 273) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "plakoglobin", "has", "a", "p53-dependent", "effect", "(", "whether", "wild-type", "or", "mutant", ")", "on", "S100A4", "expression", "as", "evidenced", "by", "the", "decreased", "trend", "of", "S100A4", "expression", "when", "plakoglobin", "was", "co-expressed", "in", "either", "H1299-", "p53-", "(", "WT", ",", "175", ",", "or", "273", ")", "cells", "." ] } ]
PMC11407042	Extend the incubation time if digestion is incomplete, but not exceed 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Extend", "the", "incubation", "time", "if", "digestion", "is", "incomplete", ",", "but", "not", "exceed", "5", "min", "." ] } ]
PMC11279598	Cell number counts were performed, and cell proliferation was quantitated by colorimetric assays using the CellTiter 96 Aqueous (Promega, San Luis Obispo, CA, USA) assay as per the manufacturer’s instructions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "number", "counts", "were", "performed", ",", "and", "cell", "proliferation", "was", "quantitated", "by", "colorimetric", "assays", "using", "the", "CellTiter", "96", "Aqueous", "(", "Promega", ",", "San", "Luis", "Obispo", ",", "CA", ",", "USA", ")", "assay", "as", "per", "the", "manufacturer", "’s", "instructions", "." ] } ]
PMC11759543	In control and vorinostat-only groups, the mice's body weight did not decrease, and the tumor did not reduce either.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "control", "and", "vorinostat-only", "groups", ",", "the", "mice", "'s", "body", "weight", "did", "not", "decrease", ",", "and", "the", "tumor", "did", "not", "reduce", "either", "." ] } ]
PMC11802855	1CXCL7 plays a crucial role in the proliferation of multiple myeloma and the activation of osteoclast signaling pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1CXCL7", "plays", "a", "crucial", "role", "in", "the", "proliferation", "of", "multiple", "myeloma", "and", "the", "activation", "of", "osteoclast", "signaling", "pathways", "." ] } ]
PMC11271278	To make cDNA for RT-qPCR, 1μg of RNA was used with the NEB LunaScript SuperMix kit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "make", "cDNA", "for", "RT-qPCR", ",", "1μg", "of", "RNA", "was", "used", "with", "the", "NEB", "LunaScript", "SuperMix", "kit", "." ] } ]
PMC9429973	ICU admission following HSCT is associated with poor prognosis, but should not be considered futile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ICU", "admission", "following", "HSCT", "is", "associated", "with", "poor", "prognosis", ",", "but", "should", "not", "be", "considered", "futile", "." ] } ]
PMC10729469	E Quantification of F-FDG PET brain glucose uptake on the day of sacrifice (n = 5—6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "Quantification", "of", "F-FDG", "PET", "brain", "glucose", "uptake", "on", "the", "day", "of", "sacrifice", "(", "n", "=", "5—6", ")", "." ] } ]
PMC11317131	We first optimized PE for inserting the PhiC31 att sites to act as a landing pad for insertion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "optimized", "PE", "for", "inserting", "the", "PhiC31", "att", "sites", "to", "act", "as", "a", "landing", "pad", "for", "insertion", "." ] } ]
PMC11755467	The recent intriguing discovery that Enoxacin modulated miRNA processing prompted us to investigate a potential anti-HIV-1 replicative effect in vitro in the context of miRNAs playing substantial roles in the HIV-1 life cycle .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "recent", "intriguing", "discovery", "that", "Enoxacin", "modulated", "miRNA", "processing", "prompted", "us", "to", "investigate", "a", "potential", "anti-HIV-1", "replicative", "effect", "in", "vitro", "in", "the", "context", "of", "miRNAs", "playing", "substantial", "roles", "in", "the", "HIV-1", "life", "cycle", "." ] } ]
PMC11310713	After 12 weeks, the OVX rats that received pharmaceutical HRT changed their body weight to −3.45% for low E2, −4.49% for low E2 + P4, −4.94% for high E2, and −4.59% for high E2 + P4 treatment, while the body weight of the GTB-injected rats was, on average, 18.4% that of ovary-intact rats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "12", "weeks", ",", "the", "OVX", "rats", "that", "received", "pharmaceutical", "HRT", "changed", "their", "body", "weight", "to", "−3.45", "%", "for", "low", "E2", ",", "−4.49", "%", "for", "low", "E2", "+", "P4", ",", "−4.94", "%", "for", "high", "E2", ",", "and", "−4.59", "%", "for", "high", "E2", "+", "P4", "treatment", ",", "while", "the", "body", "weight", "of", "the", "GTB-injected", "rats", "was", ",", "on", "average", ",", "18.4", "%", "that", "of", "ovary-intact", "rats", "." ] } ]
PMC11786156	Cluster of Differentiation 54 (CD54), also known as intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cluster", "of", "Differentiation", "54", "(", "CD54", ")", ",", "also", "known", "as", "intracellular", "adhesion", "molecule-1", "(", "ICAM-1", ")", ",", "is", "a", "transmembrane", "glycoprotein", "belonging", "to", "the", "immunoglobulin", "superfamily", "." ] } ]
PMC9919300	Data are expressed as the fold change using 2 method referred to “control plus steatogenic medium (P/O)” as the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "as", "the", "fold", "change", "using", "2", "method", "referred", "to", "“", "control", "plus", "steatogenic", "medium", "(", "P/O", ")", "”", "as", "the", "control", "group", "." ] } ]
PMC11225860	SCID mice were injected with 1 × 106 VAL cells in sterile saline subcutaneously in the left flank.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SCID", "mice", "were", "injected", "with", "1", "×", "106", "VAL", "cells", "in", "sterile", "saline", "subcutaneously", "in", "the", "left", "flank", "." ] } ]
PMC11767817	The cumene hydroperoxide was used at a concentration of 4.5 mM. The cells were washed twice with DPBS and resuspended in 200 µL of DPBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cumene", "hydroperoxide", "was", "used", "at", "a", "concentration", "of", "4.5", "mM.", "The", "cells", "were", "washed", "twice", "with", "DPBS", "and", "resuspended", "in", "200", "µL", "of", "DPBS", "." ] } ]
PMC11590005	Students enrolled in private dental schools had high-er B-MRS sum-score than those from public dental schools (p = 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Students", "enrolled", "in", "private", "dental", "schools", "had", "high-er", "B-MRS", "sum-score", "than", "those", "from", "public", "dental", "schools", "(", "p", "=", "0.001", ")", "." ] } ]
PMC10047551	EGFR TKI resistance mechanisms are pleiotropic and involve secondary EGFR mutations, amplification of the mesenchymal–epithelial transition factor proto-oncogene (c-MET), and epithelial–mesenchymal transition (EMT) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EGFR", "TKI", "resistance", "mechanisms", "are", "pleiotropic", "and", "involve", "secondary", "EGFR", "mutations", ",", "amplification", "of", "the", "mesenchymal", "–", "epithelial", "transition", "factor", "proto-oncogene", "(", "c-MET", ")", ",", "and", "epithelial", "–", "mesenchymal", "transition", "(", "EMT", ")", "." ] } ]
PMC11306331	We chose MBP as a lead candidate (size: 41 Da; pI = 5.2; see Fig. S1A for surface electrostatics and aromatic residues), a protein commonly used to increase the solubility of proteins purified from bacterial expression systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "chose", "MBP", "as", "a", "lead", "candidate", "(", "size", ":", "41", "Da", ";", "pI", "=", "5.2", ";", "see", "Fig.", "S1A", "for", "surface", "electrostatics", "and", "aromatic", "residues", ")", ",", "a", "protein", "commonly", "used", "to", "increase", "the", "solubility", "of", "proteins", "purified", "from", "bacterial", "expression", "systems", "." ] } ]
PMC11656657	In contrast, in mice treated with CAR.GD2 T-cells, we observed a significant increase of circulating T-cells from 13.44% ± 11.60% at day + 21 to 25.48% ± 10.65% at day + 47 (p = 0.04) (Fig. 4E), with human T-cells as well as CAR + T-cells being detectable up to the last time-point of the experiment (day + 75; Supplemental Fig. 9C), suggesting a consistent CAR representation in the circulating T-cells over time (Supplemental Fig. 9C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "in", "mice", "treated", "with", "CAR.GD2", "T-cells", ",", "we", "observed", "a", "significant", "increase", "of", "circulating", "T-cells", "from", "13.44", "%", "±", "11.60", "%", "at", "day", "+", "21", "to", "25.48", "%", "±", "10.65", "%", "at", "day", "+", "47", "(", "p", "=", "0.04", ")", "(", "Fig.", "4E", ")", ",", "with", "human", "T-cells", "as", "well", "as", "CAR", "+", "T-cells", "being", "detectable", "up", "to", "the", "last", "time-point", "of", "the", "experiment", "(", "day", "+", "75", ";", "Supplemental", "Fig.", "9C", ")", ",", "suggesting", "a", "consistent", "CAR", "representation", "in", "the", "circulating", "T-cells", "over", "time", "(", "Supplemental", "Fig.", "9C", ")", "." ] } ]
PMC11063646	Utilizing Design-Expert (Version 11, State-Ease, Inc.), the optimization process was facilitated with eleven experimental runs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Utilizing", "Design-Expert", "(", "Version", "11", ",", "State-Ease", ",", "Inc.", ")", ",", "the", "optimization", "process", "was", "facilitated", "with", "eleven", "experimental", "runs", "." ] } ]
PMC7334607	Bottom, a plot of the dose-response curve for Replicate 5 and all control replicates in response to dactinomycin at the VDC4 time point.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bottom", ",", "a", "plot", "of", "the", "dose-response", "curve", "for", "Replicate", "5", "and", "all", "control", "replicates", "in", "response", "to", "dactinomycin", "at", "the", "VDC4", "time", "point", "." ] } ]
PMC10158546	We also noticed that slower migrating species of PrP were lost upon differentiation in both ReN 129 M and WT cells, whereas faster migrating species became predominant (Figure 3b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "noticed", "that", "slower", "migrating", "species", "of", "PrP", "were", "lost", "upon", "differentiation", "in", "both", "ReN", "129", "M", "and", "WT", "cells", ",", "whereas", "faster", "migrating", "species", "became", "predominant", "(", "Figure", "3b", ")", "." ] } ]
PMC11774251	In addition, the expression of inflammation-related genes, including IL-1β, S100A7, CXCL2, CXCL5, CXCL8, and CCL3, was significantly upregulated in TNF-α-induced HaCaT cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "addition", ",", "the", "expression", "of", "inflammation-related", "genes", ",", "including", "IL-1β", ",", "S100A7", ",", "CXCL2", ",", "CXCL5", ",", "CXCL8", ",", "and", "CCL3", ",", "was", "significantly", "upregulated", "in", "TNF-α-induced", "HaCaT", "cells", "." ] } ]
PMC11420784	The interaction between PI3P and target proteins is mediated by a conserved zinc-finger domain, FYVE .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "interaction", "between", "PI3P", "and", "target", "proteins", "is", "mediated", "by", "a", "conserved", "zinc-finger", "domain", ",", "FYVE", "." ] } ]
PMC11194678	We further showed that STAU1-overexpressed cells treated with bafilomycin A1 (BafA1, an inhibitor of autophagosome–lysosome fusion) did not further increase LC3-II and p62 levels (Fig. S3 D), demonstrating that STAU1 was indeed involved in inhibiting autophagosome–lysosome fusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "showed", "that", "STAU1-overexpressed", "cells", "treated", "with", "bafilomycin", "A1", "(", "BafA1", ",", "an", "inhibitor", "of", "autophagosome", "–", "lysosome", "fusion", ")", "did", "not", "further", "increase", "LC3-II", "and", "p62", "levels", "(", "Fig.", "S3", "D", ")", ",", "demonstrating", "that", "STAU1", "was", "indeed", "involved", "in", "inhibiting", "autophagosome", "–", "lysosome", "fusion", "." ] } ]
PMC11252553	The findings indicate that increasing the concentration of Taurine beyond 100 μM can lead to decreasing lymphocyte viability of the experimental group at both 48 and 72 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "findings", "indicate", "that", "increasing", "the", "concentration", "of", "Taurine", "beyond", "100", "μM", "can", "lead", "to", "decreasing", "lymphocyte", "viability", "of", "the", "experimental", "group", "at", "both", "48", "and", "72", "hours", "." ] } ]
PMC10587429	Gate viable cells and exclude cell debris.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gate", "viable", "cells", "and", "exclude", "cell", "debris", "." ] } ]
PMC10854447	C18H13N5O3: C, 62.24; H, 3.77; N, 20.16.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C18H13N5O3", ":", "C", ",", "62.24", ";", "H", ",", "3.77", ";", "N", ",", "20.16", "." ] } ]
PMC11322866	In summary, increased phosphorylation of ERK1/2 is required for cellular senescence induced by the inhibition of EZH2 in MM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", ",", "increased", "phosphorylation", "of", "ERK1/2", "is", "required", "for", "cellular", "senescence", "induced", "by", "the", "inhibition", "of", "EZH2", "in", "MM", "cells", "." ] } ]
PMC11585994	Each sample was prepared in triplicate (n = 3), with three measurements conducted for each sample using the Zetasizer Nano ZS in Jinan University Analytical and Testing Center.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "sample", "was", "prepared", "in", "triplicate", "(", "n", "=", "3", ")", ",", "with", "three", "measurements", "conducted", "for", "each", "sample", "using", "the", "Zetasizer", "Nano", "ZS", "in", "Jinan", "University", "Analytical", "and", "Testing", "Center", "." ] } ]
PMC11703896	The 3D images show rapamycin’s positioning within the receptor binding pockets, highlighting key hydrophobic and hydrogen bond interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "3D", "images", "show", "rapamycin", "’s", "positioning", "within", "the", "receptor", "binding", "pockets", ",", "highlighting", "key", "hydrophobic", "and", "hydrogen", "bond", "interactions", "." ] } ]
PMC11534377	Subsequently, the microarray slides were scanned using an Agilent G2565CA microarray scanner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "microarray", "slides", "were", "scanned", "using", "an", "Agilent", "G2565CA", "microarray", "scanner", "." ] } ]
PMC6742971	We observed that the high avidity clone 212 produced higher numbers of spots in comparison with the low avidity clone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", "that", "the", "high", "avidity", "clone", "212", "produced", "higher", "numbers", "of", "spots", "in", "comparison", "with", "the", "low", "avidity", "clone", "." ] } ]
PMC11512230	In addition, virus particles are relatively easy and rapid to grow in plants, and their production is inexpensive and scalable .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "virus", "particles", "are", "relatively", "easy", "and", "rapid", "to", "grow", "in", "plants", ",", "and", "their", "production", "is", "inexpensive", "and", "scalable", "." ] } ]
PMC11228511	A description is provided in SI Appendix.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "description", "is", "provided", "in", "SI", "Appendix", "." ] } ]
PMC9429973	Results: Using an unsupervised method, 4 patient clusters were identified that represented 10%, 57%, 15%, and 18%, respectively, of the total 164 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Using", "an", "unsupervised", "method", ",", "4", "patient", "clusters", "were", "identified", "that", "represented", "10", "%", ",", "57", "%", ",", "15", "%", ",", "and", "18", "%", ",", "respectively", ",", "of", "the", "total", "164", "patients", "." ] } ]
PMC11655536	Interestingly, the lysosomes in the HA-treated MM cells were swelling (Fig. 3H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "the", "lysosomes", "in", "the", "HA-treated", "MM", "cells", "were", "swelling", "(", "Fig.", "3H", ")", "." ] } ]
PMC10940855	It also contains various growth factors (TGFβ, FGF) and proteolytic enzymes (plasminogen, tPA, MMPs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "also", "contains", "various", "growth", "factors", "(", "TGFβ", ",", "FGF", ")", "and", "proteolytic", "enzymes", "(", "plasminogen", ",", "tPA", ",", "MMPs", ")", "." ] } ]
PMC11012012	SLAMF7/CD319, along with SLAMF1/CD150, was shown to affect the degranulation capacity of primary NK cells from CLL patients and have an antagonistic effect on the BCR pathway via recruitment of prohibitin-2 (PHB2) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SLAMF7/CD319", ",", "along", "with", "SLAMF1/CD150", ",", "was", "shown", "to", "affect", "the", "degranulation", "capacity", "of", "primary", "NK", "cells", "from", "CLL", "patients", "and", "have", "an", "antagonistic", "effect", "on", "the", "BCR", "pathway", "via", "recruitment", "of", "prohibitin-2", "(", "PHB2", ")", "." ] } ]
PMC11798926	Cells were live labeled on ice with appropriate primary and secondary antibodies to recognize an extracellular epitope tag, then fixed and stained for total expression of the same molecule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "live", "labeled", "on", "ice", "with", "appropriate", "primary", "and", "secondary", "antibodies", "to", "recognize", "an", "extracellular", "epitope", "tag", ",", "then", "fixed", "and", "stained", "for", "total", "expression", "of", "the", "same", "molecule", "." ] } ]
PMC11366496	The outcomes indicated that only p‐JAK2, p‐STAT3, and c‐Myc were downregulated by RNF122 knocking down while promoted by RNF122 overexpression (Figure 4A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "outcomes", "indicated", "that", "only", "p‐JAK2", ",", "p‐STAT3", ",", "and", "c‐Myc", "were", "downregulated", "by", "RNF122", "knocking", "down", "while", "promoted", "by", "RNF122", "overexpression", "(", "Figure", "4A", ",", "B", ")", "." ] } ]
PMC11122631	Thus, the DP4+ probability analysis was selected to determine the configuration of C-4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "the", "DP4", "+", "probability", "analysis", "was", "selected", "to", "determine", "the", "configuration", "of", "C-4", "." ] } ]
PMC10907726	All other data relevant to this study are included within this publication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "other", "data", "relevant", "to", "this", "study", "are", "included", "within", "this", "publication", "." ] } ]
PMC9429973	However, resistance caused by BTK mutations, which can abrogate BTKi binding capacity or BTK scaffold function, or cause kinase hyper activation, may limit therapeutic options in subsequent lines of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "resistance", "caused", "by", "BTK", "mutations", ",", "which", "can", "abrogate", "BTKi", "binding", "capacity", "or", "BTK", "scaffold", "function", ",", "or", "cause", "kinase", "hyper", "activation", ",", "may", "limit", "therapeutic", "options", "in", "subsequent", "lines", "of", "therapy", "." ] } ]
PMC11577421	In contrast, ABNPs lacking attractive interactions with surface GAGs may be particularly suited for selective drug delivery to cells with a damaged glycocalyx, which is typical of various pathological conditions, such as atherosclerosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "ABNPs", "lacking", "attractive", "interactions", "with", "surface", "GAGs", "may", "be", "particularly", "suited", "for", "selective", "drug", "delivery", "to", "cells", "with", "a", "damaged", "glycocalyx", ",", "which", "is", "typical", "of", "various", "pathological", "conditions", ",", "such", "as", "atherosclerosis", "." ] } ]
PMC11047729	Perfluorooctanesulfonate (PFOS) is a global pollutant that can cause toxic effects on various cells, including blood cells, which can result in leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Perfluorooctanesulfonate", "(", "PFOS", ")", "is", "a", "global", "pollutant", "that", "can", "cause", "toxic", "effects", "on", "various", "cells", ",", "including", "blood", "cells", ",", "which", "can", "result", "in", "leukemia", "." ] } ]
PMC11535726	The aligned Fasta file was converted into a Nexus format for subsequent Bayesian analysis using AliView version 1.27 (Daniel et al. 2010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "aligned", "Fasta", "file", "was", "converted", "into", "a", "Nexus", "format", "for", "subsequent", "Bayesian", "analysis", "using", "AliView", "version", "1.27", "(", "Daniel", "et", "al.", "2010", ")", "." ] } ]
PMC9429973	Aims: Although hip arthroplasty-derived BM serves as an available resource for non-malignant hematopoietic cell research, the BMAT component of this BM and its’ impact on hematopoietic progenitors is not yet revealed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Although", "hip", "arthroplasty-derived", "BM", "serves", "as", "an", "available", "resource", "for", "non-malignant", "hematopoietic", "cell", "research", ",", "the", "BMAT", "component", "of", "this", "BM", "and", "its", "’", "impact", "on", "hematopoietic", "progenitors", "is", "not", "yet", "revealed", "." ] } ]
PMC9429973	Pre-treatment presence of somatic mutations were associated with development of grade 3/4 hematological toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pre-treatment", "presence", "of", "somatic", "mutations", "were", "associated", "with", "development", "of", "grade", "3/4", "hematological", "toxicity", "." ] } ]
PMC11518994	This report sheds light on diverse mechanisms contributing to leukemogenesis in the context of PAX5 germline mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "report", "sheds", "light", "on", "diverse", "mechanisms", "contributing", "to", "leukemogenesis", "in", "the", "context", "of", "PAX5", "germline", "mutation", "." ] } ]
PMC9581083	Since its emergence in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) has had devastating effects worldwide, with more than 362 million confirmed cases and 5.62 million deaths globally by early February 2022 (Wu et al., 2020a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "its", "emergence", "in", "December", "2019", ",", "severe", "acute", "respiratory", "syndrome", "coronavirus", "2", "(", "SARS-CoV-2", ",", "COVID-19", ")", "has", "had", "devastating", "effects", "worldwide", ",", "with", "more", "than", "362", "million", "confirmed", "cases", "and", "5.62", "million", "deaths", "globally", "by", "early", "February", "2022", "(", "Wu", "et", "al.", ",", "2020a", ")", "." ] } ]
PMC11441402	Each of the existing methods have limitations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "of", "the", "existing", "methods", "have", "limitations", "." ] } ]
PMC11422150	The results and previous publications utilizing kinematic analyses provide strong evidence supporting the use of kinematic analyses in both rodent experiments and clinical studies (DiGiovanna et al., 2016; Kawai et al., 2015; Miri et al., 2017; Ueno and Yamashita, 2011; Ueno et al., 2018), which was very effective in detecting the subtle discrepancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "and", "previous", "publications", "utilizing", "kinematic", "analyses", "provide", "strong", "evidence", "supporting", "the", "use", "of", "kinematic", "analyses", "in", "both", "rodent", "experiments", "and", "clinical", "studies", "(", "DiGiovanna", "et", "al.", ",", "2016", ";", "Kawai", "et", "al.", ",", "2015", ";", "Miri", "et", "al.", ",", "2017", ";", "Ueno", "and", "Yamashita", ",", "2011", ";", "Ueno", "et", "al.", ",", "2018", ")", ",", "which", "was", "very", "effective", "in", "detecting", "the", "subtle", "discrepancy", "." ] } ]
PMC9545474	All reactions were performed under standard Schlenk conditions unless otherwise stated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "reactions", "were", "performed", "under", "standard", "Schlenk", "conditions", "unless", "otherwise", "stated", "." ] } ]
PMC11127909	An ATP luminescence 1-step assay kit (PerkinElmer; #6016731) was used to measure the ATP concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "ATP", "luminescence", "1-step", "assay", "kit", "(", "PerkinElmer", ";", "#", "6016731", ")", "was", "used", "to", "measure", "the", "ATP", "concentration", "." ] } ]
PMC11543853	Previous studies demonstrated that enteroviruses utilize clathrin-dependent, caveolin-dependent, and other types of endocytosis for cell entry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "demonstrated", "that", "enteroviruses", "utilize", "clathrin-dependent", ",", "caveolin-dependent", ",", "and", "other", "types", "of", "endocytosis", "for", "cell", "entry", "." ] } ]
PMC11449273	Cells from 100 mm cultures of H1299 and H1299-p53-(WT, R175H, R273H) transfectants were extracted in 750 μL RIPA lysis buffer for 20 min on a rocker-rotator at 4°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "from", "100", "mm", "cultures", "of", "H1299", "and", "H1299-p53-(WT", ",", "R175H", ",", "R273H", ")", "transfectants", "were", "extracted", "in", "750", "μL", "RIPA", "lysis", "buffer", "for", "20", "min", "on", "a", "rocker-rotator", "at", "4", "°", "C", "." ] } ]
PMC11185260	Induction of apoptosis was monitored via Annexin V/PI staining in A-204.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "Induction", "of", "apoptosis", "was", "monitored", "via", "Annexin", "V/PI", "staining", "in", "A-204", "." ] } ]
PMC11026382	DHFR kcat and Km were determined under Michaelis-Menten conditions with saturating concentrations of NADPH as in prior work.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DHFR", "kcat", "and", "Km", "were", "determined", "under", "Michaelis-Menten", "conditions", "with", "saturating", "concentrations", "of", "NADPH", "as", "in", "prior", "work", "." ] } ]
PMC11742431	It could be found that the proteins containing Nb4A cleaved by Furin protease were gradually enriched intracellularly with increasing time, but they could not enter the nucleus (Figure 6A,E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "could", "be", "found", "that", "the", "proteins", "containing", "Nb4A", "cleaved", "by", "Furin", "protease", "were", "gradually", "enriched", "intracellularly", "with", "increasing", "time", ",", "but", "they", "could", "not", "enter", "the", "nucleus", "(", "Figure", "6A", ",", "E", ")", "." ] } ]
PMC11696576	The organic solvent was evaporated under reduced pressure and the residue was purified by column chromatography [EtOAc-petroleum ether (bp 40–60 °C), 1:9].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "organic", "solvent", "was", "evaporated", "under", "reduced", "pressure", "and", "the", "residue", "was", "purified", "by", "column", "chromatography", "[", "EtOAc-petroleum", "ether", "(", "bp", "40–60", "°", "C", ")", ",", "1:9", "]", "." ] } ]
PMC10955424	Overexpression of c-MET was reported in 7–27 % of OC patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "c-MET", "was", "reported", "in", "7–27", "%", "of", "OC", "patients", "." ] } ]
PMC6627640	The TCGA and other exome sequencing studies have not identified any recurrent mutations or genomic alterations in PRC1 and PRC2 genes in TGCTs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TCGA", "and", "other", "exome", "sequencing", "studies", "have", "not", "identified", "any", "recurrent", "mutations", "or", "genomic", "alterations", "in", "PRC1", "and", "PRC2", "genes", "in", "TGCTs", "." ] } ]
PMC10998613	We also repeated the measurements in HCC4006 cells, a human lung cancer line in which the endogenous expression of CXCR4 and β2AR is low.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "repeated", "the", "measurements", "in", "HCC4006", "cells", ",", "a", "human", "lung", "cancer", "line", "in", "which", "the", "endogenous", "expression", "of", "CXCR4", "and", "β2AR", "is", "low", "." ] } ]

PMC11596967

The ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) assay was performed following the modified protocol by Re et al. .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ABTS", "(", "2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic", "acid", ")", ")", "assay", "was", "performed", "following", "the", "modified", "protocol", "by", "Re", "et", "al.", "." ] } ]

PMC11248911

All experiments were conducted in triplicate (n = 3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "conducted", "in", "triplicate", "(", "n", "=", "3", ")", "." ] } ]

PMC11546117

Within the OAT subfamily, we showed expression, even if very low, of OAT1 (SLC22A6), OAT2 (SLC22A7), and OAT3 (SCL22A8), while these genes were below the detection level in non-lactating cells according to Alcorn et al. (2022) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "the", "OAT", "subfamily", ",", "we", "showed", "expression", ",", "even", "if", "very", "low", ",", "of", "OAT1", "(", "SLC22A6", ")", ",", "OAT2", "(", "SLC22A7", ")", ",", "and", "OAT3", "(", "SCL22A8", ")", ",", "while", "these", "genes", "were", "below", "the", "detection", "level", "in", "non-lactating", "cells", "according", "to", "Alcorn", "et", "al.", "(", "2022", ")", "." ] } ]

PMC9577200

Then, 2 ml of LB medium was added to the mixture in 5 ml tubes, and the tubes were kept on a rotary shaker at 120 rpm and 30°C.

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PMC11592837

DOX was reported to generate reactive oxygen species, lipid peroxidation, membrane damage and mitochondrial degeneration .

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PMC3203927

An interaction with a material which yields cells that emulate in vivo conditions would be most desirable.

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PMC5363531

Genomic DNA (gDNA) was extracted using Wizard Genomic DNA Purification Kit (Promega) following the manufacturer's instructions.

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PMC8922418

However, the difficulty and complexity of pegRNA design for PE are much higher than those of sgRNA for BE.

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PMC9429973

These data indicate that MRK-560 synergizes with dexamethasone via downregulation of HES-1 (downstream of NOTCH1), resulting in enhanced glucocorticoid signaling with higher BIM expression levels and apoptosis.

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PMC6901583

This work explored whether BRD4 was associated with this pathway and reported that increased levels of BRD4 led to the in vitro and in vivo formation of HUVEC tubes.

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PMC7171147

There are two possible explanations for co-activation of FAO and fatty acid synthesis.

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PMC9096373

Specific-pathogen-free (SPF) feeding was carried out at the medical laboratory animal center.

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PMC11347429

Pathway analysis for DEGs between infected patients and healthy controls agreed with other studies of influenza-infected patients regarding upregulation of common virus-host defense pathways ( Figure 2 ; Data file 6 ) (17–33) and other respiratory virus infections (33).

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PMC9822769

Very recently, the role of volume-regulated anion channels VRACs, best known for their role in cell-volume homeostasis, has been postulated in the transport of cisplatin and its Pt(II) congeners .

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PMC11228511

To test this hypothesis, we used doxycycline (Dox)-inducible vectors to create SMCs that express prelamin A (which is processed to mature lamin A) as well as SMCs that express progerin.

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PMC11265931

Subsequently, 100 μL of prepared Streptavidin solution was added to each labeled well and incubated for 45 min at room temperature with gentle shaking.

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PMC7053076

Various members of the NF-κB family are constitutively activated in many cancers via one of the two pathways: the canonical pathway involving RelA, NF-κB1 p50 and c-Rel and the non-canonical pathway engaging RelB and NF-κB2 p52.

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PMC11792766

Data are shown as mean + standard error of the mean (SEM) (n = 9).

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PMC6182045

Affinity purified polyclonal goat antibodies, raised against an equimolar mixture of purified gp120s from clade B (MN), clade C (CN97001), and clade E (TH023) gp120s, was used as a positive control for the FIA binding assays.

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PMC11388384

SCUBE1 expanded SHH signaling gradients in a dose-dependent manner.

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PMC11335267

Receptors for leptin (LepR), ghrelin (GHSR), adenosine (AdRA1), melanocortin (MC3R and MC4R), glucagon-like peptide 1 (GLP1R) and erythropoietin (EpoR) were tested (n = 8 per genotype except for EpoR, 5 wild type and 6 Alx3-deficient mice). (

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PMC9429973

No changes in IgG levels were observed in patients treated with placebo during that time.

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PMC11434983

The cytotoxicity of the new compound is also within the range of the cytotoxic activity reported for the first generation EGFR TKIs currently used in clinical practice since, in the literature, the IC50 values for gefitinib, erlotinib, lapatinib, using the A431 cell line, range from 1.33 to 4.80 μΜ .

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PMC7189327

Additionally, CYFIP2, HOXB5, PTPN3, MARCKSL, CDC20, and PTCH1 had superior diagnostic values for BCC prediction.

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PMC11763764

After washing with 1× wash buffer A twice, the ligation mix was incubated for 30 min at 37 °C.

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PMC10006224

We next defined “gained” loops as those called only in NIPBL KD replicates and “lost” loops as those called only in wild type replicates.

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PMC11047729

Fatty acids C18–C22 directly affect telomerase activity.

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PMC11640247

Biochemical and cell biological analyses indicated that RAC3-R66W functions as an activated variant in vitro (Figure 1 and Figure 2).

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PMC9872547

Free curcumin with a higher concentration (50 μM) could induce apoptosis in 25.9% of cells (Figure 2).

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PMC11711347

Cisplatin functions as a cytostatic agent by inhibiting DNA synthesis, leading to cancer cell death .

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PMC9429973

In 2014, ibrutinib was approved by the European Medicines Agency and made available to CLL pts in Germany.

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PMC8633974

After 72 hours following electroporation, ACH2 cells were stimulated with TNF-α (15 ng/mL).

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PMC11752740

For this study, we used fresh Pistacia vera var.

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PMC11806613

Quantification of protein expressions are shown on top.

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PMC6892818

Lysate from effector (3T3CD40L) cells alone (20 µg protein/lane) served as negative control (NC) and confirmed the human-protein specificity of the anti-TRAF1 (a), anti-TRAF2 (b) and anti-TRAF3 (c) antibodies.

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PMC11748335

Hence, we downloaded TE regions from the UCSC database and obtained DMV regions from a previous study .

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PMC11449273

Conversely, plakoglobin has a p53-dependent effect (whether wild-type or mutant) on S100A4 expression as evidenced by the decreased trend of S100A4 expression when plakoglobin was co-expressed in either H1299- p53- (WT, 175, or 273) cells.

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PMC11407042

Extend the incubation time if digestion is incomplete, but not exceed 5 min.

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PMC11279598

Cell number counts were performed, and cell proliferation was quantitated by colorimetric assays using the CellTiter 96 Aqueous (Promega, San Luis Obispo, CA, USA) assay as per the manufacturer’s instructions .

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PMC11759543

In control and vorinostat-only groups, the mice's body weight did not decrease, and the tumor did not reduce either.

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PMC11802855

1CXCL7 plays a crucial role in the proliferation of multiple myeloma and the activation of osteoclast signaling pathways.

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PMC11271278

To make cDNA for RT-qPCR, 1μg of RNA was used with the NEB LunaScript SuperMix kit.

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PMC9429973

ICU admission following HSCT is associated with poor prognosis, but should not be considered futile.

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PMC10729469

E Quantification of F-FDG PET brain glucose uptake on the day of sacrifice (n = 5—6).

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PMC11317131

We first optimized PE for inserting the PhiC31 att sites to act as a landing pad for insertion.

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PMC11755467

The recent intriguing discovery that Enoxacin modulated miRNA processing prompted us to investigate a potential anti-HIV-1 replicative effect in vitro in the context of miRNAs playing substantial roles in the HIV-1 life cycle .

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PMC11310713

After 12 weeks, the OVX rats that received pharmaceutical HRT changed their body weight to −3.45% for low E2, −4.49% for low E2 + P4, −4.94% for high E2, and −4.59% for high E2 + P4 treatment, while the body weight of the GTB-injected rats was, on average, 18.4% that of ovary-intact rats.

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PMC11786156

Cluster of Differentiation 54 (CD54), also known as intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily.

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PMC9919300

Data are expressed as the fold change using 2 method referred to “control plus steatogenic medium (P/O)” as the control group.

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PMC11225860

SCID mice were injected with 1 × 106 VAL cells in sterile saline subcutaneously in the left flank.

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PMC11767817

The cumene hydroperoxide was used at a concentration of 4.5 mM. The cells were washed twice with DPBS and resuspended in 200 µL of DPBS.

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PMC11590005

Students enrolled in private dental schools had high-er B-MRS sum-score than those from public dental schools (p = 0.001).

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PMC10047551

EGFR TKI resistance mechanisms are pleiotropic and involve secondary EGFR mutations, amplification of the mesenchymal–epithelial transition factor proto-oncogene (c-MET), and epithelial–mesenchymal transition (EMT) .

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PMC11306331

We chose MBP as a lead candidate (size: 41 Da; pI = 5.2; see Fig. S1A for surface electrostatics and aromatic residues), a protein commonly used to increase the solubility of proteins purified from bacterial expression systems.

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PMC11656657

In contrast, in mice treated with CAR.GD2 T-cells, we observed a significant increase of circulating T-cells from 13.44% ± 11.60% at day + 21 to 25.48% ± 10.65% at day + 47 (p = 0.04) (Fig. 4E), with human T-cells as well as CAR + T-cells being detectable up to the last time-point of the experiment (day + 75; Supplemental Fig. 9C), suggesting a consistent CAR representation in the circulating T-cells over time (Supplemental Fig. 9C).

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PMC11063646

Utilizing Design-Expert (Version 11, State-Ease, Inc.), the optimization process was facilitated with eleven experimental runs.

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PMC7334607

Bottom, a plot of the dose-response curve for Replicate 5 and all control replicates in response to dactinomycin at the VDC4 time point.

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PMC10158546

We also noticed that slower migrating species of PrP were lost upon differentiation in both ReN 129 M and WT cells, whereas faster migrating species became predominant (Figure 3b).

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PMC11774251

In addition, the expression of inflammation-related genes, including IL-1β, S100A7, CXCL2, CXCL5, CXCL8, and CCL3, was significantly upregulated in TNF-α-induced HaCaT cells.

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PMC11420784

The interaction between PI3P and target proteins is mediated by a conserved zinc-finger domain, FYVE .

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PMC11194678

We further showed that STAU1-overexpressed cells treated with bafilomycin A1 (BafA1, an inhibitor of autophagosome–lysosome fusion) did not further increase LC3-II and p62 levels (Fig. S3 D), demonstrating that STAU1 was indeed involved in inhibiting autophagosome–lysosome fusion.

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PMC11252553

The findings indicate that increasing the concentration of Taurine beyond 100 μM can lead to decreasing lymphocyte viability of the experimental group at both 48 and 72 hours.

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PMC10587429

Gate viable cells and exclude cell debris.

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PMC10854447

C18H13N5O3: C, 62.24; H, 3.77; N, 20.16.

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PMC11322866

In summary, increased phosphorylation of ERK1/2 is required for cellular senescence induced by the inhibition of EZH2 in MM cells.

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PMC11585994

Each sample was prepared in triplicate (n = 3), with three measurements conducted for each sample using the Zetasizer Nano ZS in Jinan University Analytical and Testing Center.

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PMC11703896

The 3D images show rapamycin’s positioning within the receptor binding pockets, highlighting key hydrophobic and hydrogen bond interactions.

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PMC11534377

Subsequently, the microarray slides were scanned using an Agilent G2565CA microarray scanner.

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PMC6742971

We observed that the high avidity clone 212 produced higher numbers of spots in comparison with the low avidity clone.

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PMC11512230

In addition, virus particles are relatively easy and rapid to grow in plants, and their production is inexpensive and scalable .

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PMC11228511

A description is provided in SI Appendix.

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PMC9429973

Results: Using an unsupervised method, 4 patient clusters were identified that represented 10%, 57%, 15%, and 18%, respectively, of the total 164 patients.

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PMC11655536

Interestingly, the lysosomes in the HA-treated MM cells were swelling (Fig. 3H).

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PMC10940855

It also contains various growth factors (TGFβ, FGF) and proteolytic enzymes (plasminogen, tPA, MMPs).

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PMC11012012

SLAMF7/CD319, along with SLAMF1/CD150, was shown to affect the degranulation capacity of primary NK cells from CLL patients and have an antagonistic effect on the BCR pathway via recruitment of prohibitin-2 (PHB2) .

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PMC11798926

Cells were live labeled on ice with appropriate primary and secondary antibodies to recognize an extracellular epitope tag, then fixed and stained for total expression of the same molecule.

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PMC11366496

The outcomes indicated that only p‐JAK2, p‐STAT3, and c‐Myc were downregulated by RNF122 knocking down while promoted by RNF122 overexpression (Figure 4A,B).

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PMC11122631

Thus, the DP4+ probability analysis was selected to determine the configuration of C-4.

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PMC10907726

All other data relevant to this study are included within this publication.

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PMC9429973

However, resistance caused by BTK mutations, which can abrogate BTKi binding capacity or BTK scaffold function, or cause kinase hyper activation, may limit therapeutic options in subsequent lines of therapy.

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PMC11577421

In contrast, ABNPs lacking attractive interactions with surface GAGs may be particularly suited for selective drug delivery to cells with a damaged glycocalyx, which is typical of various pathological conditions, such as atherosclerosis.

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PMC11047729

Perfluorooctanesulfonate (PFOS) is a global pollutant that can cause toxic effects on various cells, including blood cells, which can result in leukemia.

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PMC11535726

The aligned Fasta file was converted into a Nexus format for subsequent Bayesian analysis using AliView version 1.27 (Daniel et al. 2010).

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PMC9429973

Aims: Although hip arthroplasty-derived BM serves as an available resource for non-malignant hematopoietic cell research, the BMAT component of this BM and its’ impact on hematopoietic progenitors is not yet revealed.

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PMC9429973

Pre-treatment presence of somatic mutations were associated with development of grade 3/4 hematological toxicity.

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PMC11518994

This report sheds light on diverse mechanisms contributing to leukemogenesis in the context of PAX5 germline mutation.

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PMC9581083

Since its emergence in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) has had devastating effects worldwide, with more than 362 million confirmed cases and 5.62 million deaths globally by early February 2022 (Wu et al., 2020a).

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PMC11441402

Each of the existing methods have limitations.

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PMC11422150

The results and previous publications utilizing kinematic analyses provide strong evidence supporting the use of kinematic analyses in both rodent experiments and clinical studies (DiGiovanna et al., 2016; Kawai et al., 2015; Miri et al., 2017; Ueno and Yamashita, 2011; Ueno et al., 2018), which was very effective in detecting the subtle discrepancy.

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PMC9545474

All reactions were performed under standard Schlenk conditions unless otherwise stated.

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PMC11127909

An ATP luminescence 1-step assay kit (PerkinElmer; #6016731) was used to measure the ATP concentration.

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PMC11543853

Previous studies demonstrated that enteroviruses utilize clathrin-dependent, caveolin-dependent, and other types of endocytosis for cell entry.

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PMC11449273

Cells from 100 mm cultures of H1299 and H1299-p53-(WT, R175H, R273H) transfectants were extracted in 750 μL RIPA lysis buffer for 20 min on a rocker-rotator at 4°C.

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PMC11185260

Induction of apoptosis was monitored via Annexin V/PI staining in A-204.

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PMC11026382

DHFR kcat and Km were determined under Michaelis-Menten conditions with saturating concentrations of NADPH as in prior work.

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PMC11742431

It could be found that the proteins containing Nb4A cleaved by Furin protease were gradually enriched intracellularly with increasing time, but they could not enter the nucleus (Figure 6A,E).

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PMC11696576

The organic solvent was evaporated under reduced pressure and the residue was purified by column chromatography [EtOAc-petroleum ether (bp 40–60 °C), 1:9].

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PMC10955424

Overexpression of c-MET was reported in 7–27 % of OC patients.

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PMC6627640

The TCGA and other exome sequencing studies have not identified any recurrent mutations or genomic alterations in PRC1 and PRC2 genes in TGCTs.

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PMC10998613

We also repeated the measurements in HCC4006 cells, a human lung cancer line in which the endogenous expression of CXCR4 and β2AR is low.

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