OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11024707	Mi-RNAs are short (∼21 nucleotides) and non-protein-coding RNA molecules that regulate post-transcriptional gene expression .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mi-RNAs", "are", "short", "(", "∼21", "nucleotides", ")", "and", "non-protein-coding", "RNA", "molecules", "that", "regulate", "post-transcriptional", "gene", "expression", "." ] } ]
PMC7841189	Compared with normal thyroid tissue, the expression of LEBP2 at both mRNA and protein levels was significantly higher in human thyroid carcinoma tissues (Fig. 1A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "with", "normal", "thyroid", "tissue", ",", "the", "expression", "of", "LEBP2", "at", "both", "mRNA", "and", "protein", "levels", "was", "significantly", "higher", "in", "human", "thyroid", "carcinoma", "tissues", "(", "Fig.", "1A", "and", "B", ")", "." ] } ]
PMC9964654	High-performance liquid chromatography (HPLC) analysis was performed on a Perkin Elmer Series 200 Pump coupled to a Perkin Elmer Series 200 UV-Vis Detector using as eluents H2O with 0.1% of trifluoroacetic acid (TFA) (A) and acetonitrile with 0.1% TFA (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High-performance", "liquid", "chromatography", "(", "HPLC", ")", "analysis", "was", "performed", "on", "a", "Perkin", "Elmer", "Series", "200", "Pump", "coupled", "to", "a", "Perkin", "Elmer", "Series", "200", "UV-Vis", "Detector", "using", "as", "eluents", "H2O", "with", "0.1", "%", "of", "trifluoroacetic", "acid", "(", "TFA", ")", "(", "A", ")", "and", "acetonitrile", "with", "0.1", "%", "TFA", "(", "B", ")", "." ] } ]
PMC11756907	The results for the ANOVA test were: p < 0.0001, n=3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "for", "the", "ANOVA", "test", "were", ":", "p", "<", "0.0001", ",", "n=3", "." ] } ]
PMC11525028	Dysregulation of ac4C modification and NAT10 impacts the proliferation and apoptosis of myeloma cells, thereby influencing tumor progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dysregulation", "of", "ac4C", "modification", "and", "NAT10", "impacts", "the", "proliferation", "and", "apoptosis", "of", "myeloma", "cells", ",", "thereby", "influencing", "tumor", "progression", "." ] } ]
PMC6222635	The ratios of these reagents used in the experiment are shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ratios", "of", "these", "reagents", "used", "in", "the", "experiment", "are", "shown", "in", "Table", "1", "." ] } ]
PMC11530949	In this study, copper oxide-silver (Ag-doped CuO) NPs were prepared using a reduction method with Ephedra intermedia extract.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "copper", "oxide-silver", "(", "Ag-doped", "CuO", ")", "NPs", "were", "prepared", "using", "a", "reduction", "method", "with", "Ephedra", "intermedia", "extract", "." ] } ]
PMC11738017	WGS data were uploaded to the European Genome-phenome Archive (EGA) under the follow study ID: EGAS50000000546.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "WGS", "data", "were", "uploaded", "to", "the", "European", "Genome-phenome", "Archive", "(", "EGA", ")", "under", "the", "follow", "study", "ID", ":", "EGAS50000000546", "." ] } ]
PMC10933092	MA is characterized by tRNA and rRNA, which have a major influence on its structure and function owing to the presence of both methyl adducts and a positive charge under physiological conditions (Roovers et al., 2004).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MA", "is", "characterized", "by", "tRNA", "and", "rRNA", ",", "which", "have", "a", "major", "influence", "on", "its", "structure", "and", "function", "owing", "to", "the", "presence", "of", "both", "methyl", "adducts", "and", "a", "positive", "charge", "under", "physiological", "conditions", "(", "Roovers", "et", "al.", ",", "2004", ")", "." ] } ]
PMC7823217	In type-I epithelial ovarian cancer type, precursor lesions are clearly defined, whereas in Type-II lesions, malignant cells may arise from the tubal and/or ovarian surface epithelium .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "type-I", "epithelial", "ovarian", "cancer", "type", ",", "precursor", "lesions", "are", "clearly", "defined", ",", "whereas", "in", "Type-II", "lesions", ",", "malignant", "cells", "may", "arise", "from", "the", "tubal", "and/or", "ovarian", "surface", "epithelium", "." ] } ]
PMC9429973	Eligibility criteria: 1.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Eligibility", "criteria", ":", "1", "." ] } ]
PMC11476004	The levels of damage in the other group were M (16 dogs) and H (4 dogs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "levels", "of", "damage", "in", "the", "other", "group", "were", "M", "(", "16", "dogs", ")", "and", "H", "(", "4", "dogs", ")", "." ] } ]
PMC10380508	Therefore, very likely inter-regulatory relationships exist between different PAX genes that are expressed in the same RCC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "very", "likely", "inter-regulatory", "relationships", "exist", "between", "different", "PAX", "genes", "that", "are", "expressed", "in", "the", "same", "RCC", "cells", "." ] } ]
PMC11026382	DHFR positions are along the horizontal axis; amino acid residues (along the vertical axis) are organized by physiochemical similarity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DHFR", "positions", "are", "along", "the", "horizontal", "axis", ";", "amino", "acid", "residues", "(", "along", "the", "vertical", "axis", ")", "are", "organized", "by", "physiochemical", "similarity", "." ] } ]
PMC8806312	Univariate Cox regression (UCR) analysis was used to identify genes whose expression was related to the overall survival of patients with OS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Univariate", "Cox", "regression", "(", "UCR", ")", "analysis", "was", "used", "to", "identify", "genes", "whose", "expression", "was", "related", "to", "the", "overall", "survival", "of", "patients", "with", "OS", "." ] } ]
PMC11321678	By combining these two gene lists, we constructed a putative NTR‐Positive TF regulatory network (Figure 5A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "combining", "these", "two", "gene", "lists", ",", "we", "constructed", "a", "putative", "NTR‐Positive", "TF", "regulatory", "network", "(", "Figure", "5A", ")", "." ] } ]
PMC6684588	P ≤ 0.001 vs. vehicle; P ≤ 0.001 vs. uninjected (contralateral) TA by one-way ANOVA with Tukey’s adjustment. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "≤", "0.001", "vs.", "vehicle", ";", "P", "≤", "0.001", "vs.", "uninjected", "(", "contralateral", ")", "TA", "by", "one-way", "ANOVA", "with", "Tukey", "’s", "adjustment", ".", "(" ] } ]
PMC11306331	Finally, we also tested single and double repeats of mEGFP to probe if condensation dissolution might be a function of cargo protein size.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "we", "also", "tested", "single", "and", "double", "repeats", "of", "mEGFP", "to", "probe", "if", "condensation", "dissolution", "might", "be", "a", "function", "of", "cargo", "protein", "size", "." ] } ]
PMC9250505	After three washings with PBS, fixed cells were permeabilized with 0.2% Triton X-100/PBS for 5 min and incubated with 5% BSA /PBS for 15 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "three", "washings", "with", "PBS", ",", "fixed", "cells", "were", "permeabilized", "with", "0.2", "%", "Triton", "X-100/PBS", "for", "5", "min", "and", "incubated", "with", "5", "%", "BSA", "/PBS", "for", "15", "min", "." ] } ]
PMC9920575	These findings suggest that the SCH extract has the potential to selectively kill tumor cells by promoting apoptosis, without harming nontumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "the", "SCH", "extract", "has", "the", "potential", "to", "selectively", "kill", "tumor", "cells", "by", "promoting", "apoptosis", ",", "without", "harming", "nontumor", "cells", "." ] } ]
PMC7171147	e Western blot of pAKT (S473) and CPT1A in ES2 cells cultured in either PBS or COL11A1-coated plates for 48 h and treated with LY294002 (20 µM) for 48 h. GAPDH was used as a loading control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "e", "Western", "blot", "of", "pAKT", "(", "S473", ")", "and", "CPT1A", "in", "ES2", "cells", "cultured", "in", "either", "PBS", "or", "COL11A1-coated", "plates", "for", "48", "h", "and", "treated", "with", "LY294002", "(", "20", "µM", ")", "for", "48", "h.", "GAPDH", "was", "used", "as", "a", "loading", "control", "." ] } ]
PMC9429973	Prospective studies are now needed to evaluate and compare DOACs to the currently recommended antithrombotic drugs for high-risk MPN patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prospective", "studies", "are", "now", "needed", "to", "evaluate", "and", "compare", "DOACs", "to", "the", "currently", "recommended", "antithrombotic", "drugs", "for", "high-risk", "MPN", "patients", "." ] } ]
PMC4839679	Staining was performed by adding 50 μL of 0.4% Sulforhodamine B in 1% acetic acid solution to every well and the plate was incubated for 10 minutes at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Staining", "was", "performed", "by", "adding", "50", "μL", "of", "0.4", "%", "Sulforhodamine", "B", "in", "1", "%", "acetic", "acid", "solution", "to", "every", "well", "and", "the", "plate", "was", "incubated", "for", "10", "minutes", "at", "room", "temperature", "." ] } ]
PMC11767725	These microorganisms are not randomly distributed but are shaped by variations in the skin’s biophysical properties, such as pH, moisture levels, lipid content, and exposure to environmental factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "microorganisms", "are", "not", "randomly", "distributed", "but", "are", "shaped", "by", "variations", "in", "the", "skin", "’s", "biophysical", "properties", ",", "such", "as", "pH", ",", "moisture", "levels", ",", "lipid", "content", ",", "and", "exposure", "to", "environmental", "factors", "." ] } ]
PMC10551595	MTT assay was determined to examine the effect of GinA or GinA/Dexa on ALL cell lines, and patient primary and control MNCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MTT", "assay", "was", "determined", "to", "examine", "the", "effect", "of", "GinA", "or", "GinA/Dexa", "on", "ALL", "cell", "lines", ",", "and", "patient", "primary", "and", "control", "MNCs", "." ] } ]
PMC11348300	Image processing included background subtraction and spatial median filtering to eliminate hot pixels and readout noise.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", "processing", "included", "background", "subtraction", "and", "spatial", "median", "filtering", "to", "eliminate", "hot", "pixels", "and", "readout", "noise", "." ] } ]
PMC8481254	To investigate whether CA can inhibit the O-GlcNAcylation and YAP level upregulated by HG, we cultured cells with normal (5.5 mM) or high (25 mM) concentrations of glucose and treated 25 mM glucose-treated cells with CA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "investigate", "whether", "CA", "can", "inhibit", "the", "O-GlcNAcylation", "and", "YAP", "level", "upregulated", "by", "HG", ",", "we", "cultured", "cells", "with", "normal", "(", "5.5", "mM", ")", "or", "high", "(", "25", "mM", ")", "concentrations", "of", "glucose", "and", "treated", "25", "mM", "glucose-treated", "cells", "with", "CA", "." ] } ]
PMC9429973	The overall mortality was 15% and the COVID-19 related mortality 10%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "overall", "mortality", "was", "15", "%", "and", "the", "COVID-19", "related", "mortality", "10", "%", "." ] } ]
PMC11474209	The remaining 2 % of the world's water supply is freshwater, of which 0.36 % is found underground in aquifers and wells, and 1.6 % is locked in glaciers and polar ice caps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "remaining", "2", "%", "of", "the", "world", "'s", "water", "supply", "is", "freshwater", ",", "of", "which", "0.36", "%", "is", "found", "underground", "in", "aquifers", "and", "wells", ",", "and", "1.6", "%", "is", "locked", "in", "glaciers", "and", "polar", "ice", "caps", "." ] } ]
PMC9429973	Interestingly, RUNX2 and IGFBP7, high-risk markers in T-ALL,2,3 were aberrantly expressed in this subset of T-ALL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "RUNX2", "and", "IGFBP7", ",", "high-risk", "markers", "in", "T-ALL,2,3", "were", "aberrantly", "expressed", "in", "this", "subset", "of", "T-ALL", "." ] } ]
PMC11718809	Details of the primers are presented in Table S4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Details", "of", "the", "primers", "are", "presented", "in", "Table", "S4", "." ] } ]
PMC11291697	In humans, serine deficiency is associated with severe neurological abnormalities including developmental delay, intellectual disability, microcephaly and seizures , while several studies detected low levels of glycine and D-serine in the plasma and cerebrospinal fluid of individuals with schizophrenia .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "humans", ",", "serine", "deficiency", "is", "associated", "with", "severe", "neurological", "abnormalities", "including", "developmental", "delay", ",", "intellectual", "disability", ",", "microcephaly", "and", "seizures", ",", "while", "several", "studies", "detected", "low", "levels", "of", "glycine", "and", "D-serine", "in", "the", "plasma", "and", "cerebrospinal", "fluid", "of", "individuals", "with", "schizophrenia", "." ] } ]
PMC11300639	a Analysis of the TCGA-KIRC dataset after sub-dividing the RNF26 into high or low expression group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Analysis", "of", "the", "TCGA-KIRC", "dataset", "after", "sub-dividing", "the", "RNF26", "into", "high", "or", "low", "expression", "group", "." ] } ]
PMC5925824	PD-L1 expression can also be up-regulated in the tumor microenvironment as a result of immune activation and production of pro-inflammatory cytokines such as interferon-gamma (IFNγ), contributing to the establishment of an “adapted” T-cell immunosuppressive milieu .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PD-L1", "expression", "can", "also", "be", "up-regulated", "in", "the", "tumor", "microenvironment", "as", "a", "result", "of", "immune", "activation", "and", "production", "of", "pro-inflammatory", "cytokines", "such", "as", "interferon-gamma", "(", "IFNγ", ")", ",", "contributing", "to", "the", "establishment", "of", "an", "“", "adapted", "”", "T-cell", "immunosuppressive", "milieu", "." ] } ]
PMC11617590	Once in the cytosol, β‐catenin is transported to the nucleus, where it interacts with the T‐cell factor/lymphoid enhancing factor (TCF), a transcription factor, and promotes the transcription of genes that regulate cell proliferation, differentiation, apoptosis, migration, infiltration, and tissue homeostasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Once", "in", "the", "cytosol", ",", "β‐catenin", "is", "transported", "to", "the", "nucleus", ",", "where", "it", "interacts", "with", "the", "T‐cell", "factor/lymphoid", "enhancing", "factor", "(", "TCF", ")", ",", "a", "transcription", "factor", ",", "and", "promotes", "the", "transcription", "of", "genes", "that", "regulate", "cell", "proliferation", ",", "differentiation", ",", "apoptosis", ",", "migration", ",", "infiltration", ",", "and", "tissue", "homeostasis", "." ] } ]
PMC11673902	Cell separation usually relies on biochemical and biophysical markers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "separation", "usually", "relies", "on", "biochemical", "and", "biophysical", "markers", "." ] } ]
PMC11727145	As regards the mitigation of donor-to-donor variability, the possibility of preparing several tissue samples from the same large tissue donation enabled the conducting of an experimental series with a single donor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "regards", "the", "mitigation", "of", "donor-to-donor", "variability", ",", "the", "possibility", "of", "preparing", "several", "tissue", "samples", "from", "the", "same", "large", "tissue", "donation", "enabled", "the", "conducting", "of", "an", "experimental", "series", "with", "a", "single", "donor", "." ] } ]
PMC9429973	Interestingly, we reported an accumulation of Fe in the mitochondria, correlating with a 2-fold increase in mitochondrial reactive oxygen species (ROS) content.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "we", "reported", "an", "accumulation", "of", "Fe", "in", "the", "mitochondria", ",", "correlating", "with", "a", "2-fold", "increase", "in", "mitochondrial", "reactive", "oxygen", "species", "(", "ROS", ")", "content", "." ] } ]
PMC11792740	This process facilitated Th17 inflammation, promoted IL-17 A-induced CD8 + T-cell exhaustion, and drove colorectal carcinogenesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "process", "facilitated", "Th17", "inflammation", ",", "promoted", "IL-17", "A-induced", "CD8", "+", "T-cell", "exhaustion", ",", "and", "drove", "colorectal", "carcinogenesis", "." ] } ]
PMC9429973	Related AEs ≥ Grade 3 (≥ 5%) were: lipase elevation (15%), rash (combined listings) (9%), and amylase elevation (7%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Related", "AEs", "≥", "Grade", "3", "(", "≥", "5", "%", ")", "were", ":", "lipase", "elevation", "(", "15", "%", ")", ",", "rash", "(", "combined", "listings", ")", "(", "9", "%", ")", ",", "and", "amylase", "elevation", "(", "7", "%", ")", "." ] } ]
PMC10994876	Previous studies have indicated that YAP has the ability to interact with p73, a transcription factor associated with p53.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "indicated", "that", "YAP", "has", "the", "ability", "to", "interact", "with", "p73", ",", "a", "transcription", "factor", "associated", "with", "p53", "." ] } ]
PMC11632064	Spearman correlation coefficients between perturbation effects (DepMap) and transcript levels (CCLE) were calculated using Prism (GraphPad Software).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spearman", "correlation", "coefficients", "between", "perturbation", "effects", "(", "DepMap", ")", "and", "transcript", "levels", "(", "CCLE", ")", "were", "calculated", "using", "Prism", "(", "GraphPad", "Software", ")", "." ] } ]
PMC10728535	The findings revealed expression variation in several proteins participating in cell adhesion including MFAP4, PCDH19, CDH2, CDH10, NRXN1, COL4A6, COL15A1, PIP5K1B, EPHA3, BOC, and CD36.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "findings", "revealed", "expression", "variation", "in", "several", "proteins", "participating", "in", "cell", "adhesion", "including", "MFAP4", ",", "PCDH19", ",", "CDH2", ",", "CDH10", ",", "NRXN1", ",", "COL4A6", ",", "COL15A1", ",", "PIP5K1B", ",", "EPHA3", ",", "BOC", ",", "and", "CD36", "." ] } ]
PMC6450504	Briefly, the cells were seeded at a density of 100,000 cells/well in 12-well plates 24 h prior to the experiment and then treated with Rhod-PE labeled 0%, 0.1%, and 0.5% PEIPOS in serum-complete medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "the", "cells", "were", "seeded", "at", "a", "density", "of", "100,000", "cells/well", "in", "12-well", "plates", "24", "h", "prior", "to", "the", "experiment", "and", "then", "treated", "with", "Rhod-PE", "labeled", "0", "%", ",", "0.1", "%", ",", "and", "0.5", "%", "PEIPOS", "in", "serum-complete", "medium", "." ] } ]
PMC11593084	PMab-117-mG2a exerted potent antitumor effects in human xenograft model, and is expected to be applicable to human cancer treatment by generating a humanized mAb, ADC, and CAR-T.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PMab-117-mG2a", "exerted", "potent", "antitumor", "effects", "in", "human", "xenograft", "model", ",", "and", "is", "expected", "to", "be", "applicable", "to", "human", "cancer", "treatment", "by", "generating", "a", "humanized", "mAb", ",", "ADC", ",", "and", "CAR-T." ] } ]
PMC9429973	Aims: to study the microenvironment and immune checkpoint of MDS by FSFCM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "to", "study", "the", "microenvironment", "and", "immune", "checkpoint", "of", "MDS", "by", "FSFCM", "." ] } ]
PMC6892818	Results are typical of tive independent experiments and are presented as background-corrected relative luminescence units (RLU).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "typical", "of", "tive", "independent", "experiments", "and", "are", "presented", "as", "background-corrected", "relative", "luminescence", "units", "(", "RLU", ")", "." ] } ]
PMC9429973	1 patient with AITL was in CR at the time of alloHSCT and remains alive, relapse and GVHD free 28 months after alloHSCT while 1 patient in PR at the time of alloHSCT is alive in CR, relapse/GVHD free 6 years later.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "patient", "with", "AITL", "was", "in", "CR", "at", "the", "time", "of", "alloHSCT", "and", "remains", "alive", ",", "relapse", "and", "GVHD", "free", "28", "months", "after", "alloHSCT", "while", "1", "patient", "in", "PR", "at", "the", "time", "of", "alloHSCT", "is", "alive", "in", "CR", ",", "relapse/GVHD", "free", "6", "years", "later", "." ] } ]
PMC11695546	The micro-dilution broth procedure was applied to test MIC of the specimens being studied by employing nutritional broth for bacterial.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "micro-dilution", "broth", "procedure", "was", "applied", "to", "test", "MIC", "of", "the", "specimens", "being", "studied", "by", "employing", "nutritional", "broth", "for", "bacterial", "." ] } ]
PMC8041314	In short, Hoechst 33342 and daunorubicin are substrates of ABC transporters that passively diffuse into the cells and become extruded by the respective ABC transporter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "short", ",", "Hoechst", "33342", "and", "daunorubicin", "are", "substrates", "of", "ABC", "transporters", "that", "passively", "diffuse", "into", "the", "cells", "and", "become", "extruded", "by", "the", "respective", "ABC", "transporter", "." ] } ]
PMC9429973	Mild peripheral blood lymphocytic subsets abnormalities were observed in ¼ of the patients, particularly in LO, and mild reduction of serum immunoglobulin class levels in ¼ of the patients, without difference between no LO/LL and LO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mild", "peripheral", "blood", "lymphocytic", "subsets", "abnormalities", "were", "observed", "in", "¼", "of", "the", "patients", ",", "particularly", "in", "LO", ",", "and", "mild", "reduction", "of", "serum", "immunoglobulin", "class", "levels", "in", "¼", "of", "the", "patients", ",", "without", "difference", "between", "no", "LO/LL", "and", "LO", "." ] } ]
PMC11767725	Follicular rupture releases keratin and sebum into the dermis, triggering a robust inflammatory response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Follicular", "rupture", "releases", "keratin", "and", "sebum", "into", "the", "dermis", ",", "triggering", "a", "robust", "inflammatory", "response", "." ] } ]
PMC9429973	Methods: The patients are randomized 1:1 between NIL and IM according to Sokal risk score (high versus intermediate/low risk) and country.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "The", "patients", "are", "randomized", "1:1", "between", "NIL", "and", "IM", "according", "to", "Sokal", "risk", "score", "(", "high", "versus", "intermediate/low", "risk", ")", "and", "country", "." ] } ]
PMC11462673	Two days after puromycin selection, both transfected control cells and LDB1 knockdown cells were collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "days", "after", "puromycin", "selection", ",", "both", "transfected", "control", "cells", "and", "LDB1", "knockdown", "cells", "were", "collected", "." ] } ]
PMC8143558	The nomenclature of these plants is usually based on their soapy qualities, such that even the common names usually include “soap” e.g., soap aloe, soapwort, soap tree, soap berry, soap bark, and soap dogwood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "nomenclature", "of", "these", "plants", "is", "usually", "based", "on", "their", "soapy", "qualities", ",", "such", "that", "even", "the", "common", "names", "usually", "include", "“", "soap", "”", "e.g.", ",", "soap", "aloe", ",", "soapwort", ",", "soap", "tree", ",", "soap", "berry", ",", "soap", "bark", ",", "and", "soap", "dogwood", "." ] } ]
PMC10907726	It is essential to recognize the limitations inherent in our investigation, which focused narrowly on the 143B osteosarcoma cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "I-CellLine", "I-CellLine", "O" ], "tokens": [ "It", "is", "essential", "to", "recognize", "the", "limitations", "inherent", "in", "our", "investigation", ",", "which", "focused", "narrowly", "on", "the", "143B", "osteosarcoma", "cell", "line", "." ] } ]
PMC11468365	is shown in Eq. (17).17[12pt] $$^=1-_)},$$2=1-MSEvarya,where18[12pt] $$var(_)=^_^- }_^)}^}.$$=∑i=1nyai-y¯ai2n.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "is", "shown", "in", "Eq.", "(17).17[12pt", "]", "$", "$", "^=1-_)},$$2=1-MSEvarya", ",", "where18[12pt", "]", "$", "$", "var(_)=^_^-", "}", "_", "^)}^}.$$=∑i=1nyai-y¯ai2n", "." ] } ]
PMC9503541	The most active fractions were F15-16C and F15-16D.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "active", "fractions", "were", "F15", "-", "16C", "and", "F15", "-", "16D", "." ] } ]
PMC10882807	Furthermore, the distribution of hsa_circ_0005397 was explored via cell fractionation, with hsa_circ_0005397 mostly located in the cytoplasm (Fig. 1G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "distribution", "of", "hsa_circ_0005397", "was", "explored", "via", "cell", "fractionation", ",", "with", "hsa_circ_0005397", "mostly", "located", "in", "the", "cytoplasm", "(", "Fig.", "1", "G", ")", "." ] } ]
PMC11541409	The underlying resistance mechanism is that growth factor-activated RTKs (FGFR, MET) share the MAPK/ERK pathway with KIT/PDGFRA, and activation of these RTKs by ligands supports survival and proliferation of GIST cells in the context of TKI treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "underlying", "resistance", "mechanism", "is", "that", "growth", "factor-activated", "RTKs", "(", "FGFR", ",", "MET", ")", "share", "the", "MAPK/ERK", "pathway", "with", "KIT/PDGFRA", ",", "and", "activation", "of", "these", "RTKs", "by", "ligands", "supports", "survival", "and", "proliferation", "of", "GIST", "cells", "in", "the", "context", "of", "TKI", "treatment", "." ] } ]
PMC11471176	However, it is crucial to acknowledge the absence of conclusive evidence substantiating this concept thus far.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "is", "crucial", "to", "acknowledge", "the", "absence", "of", "conclusive", "evidence", "substantiating", "this", "concept", "thus", "far", "." ] } ]
PMC11656380	Animal experimental procedures were performed according to guidelines for the Institutional Animal Care and Use Committee of Sojo University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Animal", "experimental", "procedures", "were", "performed", "according", "to", "guidelines", "for", "the", "Institutional", "Animal", "Care", "and", "Use", "Committee", "of", "Sojo", "University", "." ] } ]
PMC11750712	The bound (TRBC1) fraction was collected by following the protocol as stated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bound", "(", "TRBC1", ")", "fraction", "was", "collected", "by", "following", "the", "protocol", "as", "stated", "." ] } ]
PMC11678130	The cells presented normal proliferation during the performed experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "presented", "normal", "proliferation", "during", "the", "performed", "experiments", "." ] } ]
PMC11723947	a Representative dot-plots showing 21 days after engraftment the percentage of WT and HP1γ KO TCR Vβ6 Tconv producing IFN-γ and IL-17A.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Representative", "dot-plots", "showing", "21", "days", "after", "engraftment", "the", "percentage", "of", "WT", "and", "HP1γ", "KO", "TCR", "Vβ6", "Tconv", "producing", "IFN-γ", "and", "IL-17A", "." ] } ]
PMC10237474	no. A2916801, Thermo Fisher Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "no.", "A2916801", ",", "Thermo", "Fisher", "Scientific", ")", "." ] } ]
PMC11564405	For example, high levels of CXCL9 and CXCL10 are associated with increased Th1 cell infiltration; CCL5 promotes the recruitment of CD8 + T cells; heightened CX3CL1 is correlated with augmented TILs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "high", "levels", "of", "CXCL9", "and", "CXCL10", "are", "associated", "with", "increased", "Th1", "cell", "infiltration", ";", "CCL5", "promotes", "the", "recruitment", "of", "CD8", "+", "T", "cells", ";", "heightened", "CX3CL1", "is", "correlated", "with", "augmented", "TILs", "." ] } ]
PMC11703992	Notably, the expression of all these inflammatory factors in DDIT4-OE-PMA were significantly lower than Blank-PMA group, which might indicate that DDIT4 triggers low-intensity inflammation in active T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "the", "expression", "of", "all", "these", "inflammatory", "factors", "in", "DDIT4-OE-PMA", "were", "significantly", "lower", "than", "Blank-PMA", "group", ",", "which", "might", "indicate", "that", "DDIT4", "triggers", "low-intensity", "inflammation", "in", "active", "T", "cells", "." ] } ]
PMC11585565	These findings suggest that the rapid degradation rates and loss of Mg efflux activity associated with these variants may serve as potential pathogenic mechanisms underlying the phenotypes of Jalili syndrome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "the", "rapid", "degradation", "rates", "and", "loss", "of", "Mg", "efflux", "activity", "associated", "with", "these", "variants", "may", "serve", "as", "potential", "pathogenic", "mechanisms", "underlying", "the", "phenotypes", "of", "Jalili", "syndrome", "." ] } ]
PMC11721587	Overexpression of Ulk3 in NIH3T3 cells also promoted Ulk3 maturation, which depended on its kinase activity, SUMOylation, and SIM (Fig. 6H).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "Ulk3", "in", "NIH3T3", "cells", "also", "promoted", "Ulk3", "maturation", ",", "which", "depended", "on", "its", "kinase", "activity", ",", "SUMOylation", ",", "and", "SIM", "(", "Fig.", "6H", ")", "." ] } ]
PMC11730000	It was considered statistically significant when p < 0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "considered", "statistically", "significant", "when", "p", "<", "0.05", "." ] } ]
PMC11411004	Cells harvested on day 7 were included in the analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "harvested", "on", "day", "7", "were", "included", "in", "the", "analysis", "." ] } ]
PMC11731614	The enrichment analysis of the predicted protein targets of let-7 and miR-23 both revealed predicted KEGG pathways related to ‘Axon Guidance,’ suggesting a possible role of KDEV small RNAs on keratinocyte-to-neuron communication.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "enrichment", "analysis", "of", "the", "predicted", "protein", "targets", "of", "let-7", "and", "miR-23", "both", "revealed", "predicted", "KEGG", "pathways", "related", "to", "‘", "Axon", "Guidance", ",", "’", "suggesting", "a", "possible", "role", "of", "KDEV", "small", "RNAs", "on", "keratinocyte-to-neuron", "communication", "." ] } ]
PMC8584319	Protein synthesis decreased in thapsigargin (Tg)-treated wild-type MEFs but not in Tg-treated mutant MEFs; however, both wild-type and mutant MEFs treated with AZD8055 showed a significant decrease in protein synthesis (Figure 1c,d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "synthesis", "decreased", "in", "thapsigargin", "(Tg)-treated", "wild-type", "MEFs", "but", "not", "in", "Tg-treated", "mutant", "MEFs", ";", "however", ",", "both", "wild-type", "and", "mutant", "MEFs", "treated", "with", "AZD8055", "showed", "a", "significant", "decrease", "in", "protein", "synthesis", "(", "Figure", "1c", ",", "d", ")", "." ] } ]
PMC11489351	Cells were trypsinized and plated (80,000 cells/dish, MCF10A; 50,000 cells/dish, RPE) in separate 3.5 cm imaging dishes for each condition (Matsunami, Dd35-14-1.5-U) and returned to the incubator for 24 h. Cells were then treated with pHi-manipulation media, and dishes were returned to the incubator overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "trypsinized", "and", "plated", "(", "80,000", "cells/dish", ",", "MCF10A", ";", "50,000", "cells/dish", ",", "RPE", ")", "in", "separate", "3.5", "cm", "imaging", "dishes", "for", "each", "condition", "(", "Matsunami", ",", "Dd35", "-", "14", "-", "1.5-U", ")", "and", "returned", "to", "the", "incubator", "for", "24", "h.", "Cells", "were", "then", "treated", "with", "pHi-manipulation", "media", ",", "and", "dishes", "were", "returned", "to", "the", "incubator", "overnight", "." ] } ]
PMC6803987	To explore the anti-hepatitis B virus effect of esculetin, a congenitally infection model of duck hepatitis B was used to explore the effect of different doses of esculetin on DHBV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "explore", "the", "anti-hepatitis", "B", "virus", "effect", "of", "esculetin", ",", "a", "congenitally", "infection", "model", "of", "duck", "hepatitis", "B", "was", "used", "to", "explore", "the", "effect", "of", "different", "doses", "of", "esculetin", "on", "DHBV", "." ] } ]
PMC11434983	H NMR (500 MHz, DMSO-d6) δH 9.7 (1H, H-6), 9.4 (1H, H-1), 8.8 (1H, H-11), 8.6 (1H, H-14), 8.3 (1H, H-4), 8.2 (1H, H-3), 8.1 (1H, H-20), 8.0 (1H, H-8), 7.9 (1H, H-9), 7.8 (1H, H-2), 7.7 (1H, H-16), 7.5 (1H, H-17), 7.5 (2H, H-18), 7.3 (3H, PPh3 para), 7.2 (6H, PPh3 meta), and 7.1 (6H, PPh3 ortho).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "NMR", "(", "500", "MHz", ",", "DMSO-d6", ")", "δH", "9.7", "(", "1H", ",", "H-6", ")", ",", "9.4", "(", "1H", ",", "H-1", ")", ",", "8.8", "(", "1H", ",", "H-11", ")", ",", "8.6", "(", "1H", ",", "H-14", ")", ",", "8.3", "(", "1H", ",", "H-4", ")", ",", "8.2", "(", "1H", ",", "H-3", ")", ",", "8.1", "(", "1H", ",", "H-20", ")", ",", "8.0", "(", "1H", ",", "H-8", ")", ",", "7.9", "(", "1H", ",", "H-9", ")", ",", "7.8", "(", "1H", ",", "H-2", ")", ",", "7.7", "(", "1H", ",", "H-16", ")", ",", "7.5", "(", "1H", ",", "H-17", ")", ",", "7.5", "(", "2H", ",", "H-18", ")", ",", "7.3", "(", "3H", ",", "PPh3", "para", ")", ",", "7.2", "(", "6H", ",", "PPh3", "meta", ")", ",", "and", "7.1", "(", "6H", ",", "PPh3", "ortho", ")", "." ] } ]
PMC11577421	Binding regions of heparin and heparan sulfate disaccharides to native albumin. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Binding", "regions", "of", "heparin", "and", "heparan", "sulfate", "disaccharides", "to", "native", "albumin", ".", "(" ] } ]
PMC11225860	depicts H&E stain from a vehicle control treated mouse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "depicts", "H&E", "stain", "from", "a", "vehicle", "control", "treated", "mouse", "." ] } ]
PMC7868205	According to Bragg’s reflection, the estimated average size of the particles was 31.12 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "Bragg", "’s", "reflection", ",", "the", "estimated", "average", "size", "of", "the", "particles", "was", "31.12", "nm", "." ] } ]
PMC11484188	Effective nanoparticles, liposomes or viral vectors can be designed to deliver miRNAs or anti-miRNAs to tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effective", "nanoparticles", ",", "liposomes", "or", "viral", "vectors", "can", "be", "designed", "to", "deliver", "miRNAs", "or", "anti-miRNAs", "to", "tumor", "cells", "." ] } ]
PMC5308810	To demonstrate the therapeutic merits of targeting CXCR4, we evaluated the cytotoxicity of CXCR4-KLA alone or in combination with other cytotoxic agents toward A2780, A2780/ADR, and SKOV3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O" ], "tokens": [ "To", "demonstrate", "the", "therapeutic", "merits", "of", "targeting", "CXCR4", ",", "we", "evaluated", "the", "cytotoxicity", "of", "CXCR4-KLA", "alone", "or", "in", "combination", "with", "other", "cytotoxic", "agents", "toward", "A2780", ",", "A2780/ADR", ",", "and", "SKOV3", "." ] } ]
PMC9386809	Cells were seeded in a 96 well plate, 10,000 cells in each well, and incubated overnight at 37 °C in a CO2 incubator.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "seeded", "in", "a", "96", "well", "plate", ",", "10,000", "cells", "in", "each", "well", ",", "and", "incubated", "overnight", "at", "37", "°", "C", "in", "a", "CO2", "incubator", "." ] } ]
PMC11354239	Acting separately or together, these factors could lead to resistance to therapeutic mAbs, a substantial decrease in therapeutic efficacy, and a high relapse rate .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Acting", "separately", "or", "together", ",", "these", "factors", "could", "lead", "to", "resistance", "to", "therapeutic", "mAbs", ",", "a", "substantial", "decrease", "in", "therapeutic", "efficacy", ",", "and", "a", "high", "relapse", "rate", "." ] } ]
PMC10578720	Inspired by these findings, we investigated whether HBV could regulate SIRT3 expression in macrophages through the TLR2-NF-κB-PGC-1α axis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inspired", "by", "these", "findings", ",", "we", "investigated", "whether", "HBV", "could", "regulate", "SIRT3", "expression", "in", "macrophages", "through", "the", "TLR2-NF-κB-PGC-1α", "axis", "." ] } ]
PMC11566417	The other luminal marker assessed, ERα , trended downwards between p10 and p20 in primary as well as immortalized MDECs irrespective of passage, albeit this did not reach a statistical significance difference (Fig. 2a and Supplemental Fig. 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "other", "luminal", "marker", "assessed", ",", "ERα", ",", "trended", "downwards", "between", "p10", "and", "p20", "in", "primary", "as", "well", "as", "immortalized", "MDECs", "irrespective", "of", "passage", ",", "albeit", "this", "did", "not", "reach", "a", "statistical", "significance", "difference", "(", "Fig.", "2a", "and", "Supplemental", "Fig.", "2", ")", "." ] } ]
PMC9429973	Median follow-up was 6 mo.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow-up", "was", "6", "mo", "." ] } ]
PMC9429973	Hematologic malignancy (34.1%, n=168) was the most common type of SPM, followed by stomach cancer in 49 (9.9%) patients, lung cancer in 44 (8.9%) patients, and colon cancer in 31 (6.3%) patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hematologic", "malignancy", "(", "34.1", "%", ",", "n=168", ")", "was", "the", "most", "common", "type", "of", "SPM", ",", "followed", "by", "stomach", "cancer", "in", "49", "(", "9.9", "%", ")", "patients", ",", "lung", "cancer", "in", "44", "(", "8.9", "%", ")", "patients", ",", "and", "colon", "cancer", "in", "31", "(", "6.3", "%", ")", "patients", "." ] } ]
PMC7171147	The role of fatty acids as substrates that induce chemoresistance is less explored compared to glucose or glutamine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role", "of", "fatty", "acids", "as", "substrates", "that", "induce", "chemoresistance", "is", "less", "explored", "compared", "to", "glucose", "or", "glutamine", "." ] } ]
PMC8978939	More precisely, while lining the floor of the β-domain in native pVHL, this flexibilized region constitutes a hydrophobic patch from where P138 establishes direct hydrogen-bonding interactions with H115 (one of the residues clamping Hyp564 from HIF-1α at the B-interface of pVHL) and Y112.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "precisely", ",", "while", "lining", "the", "floor", "of", "the", "β-domain", "in", "native", "pVHL", ",", "this", "flexibilized", "region", "constitutes", "a", "hydrophobic", "patch", "from", "where", "P138", "establishes", "direct", "hydrogen-bonding", "interactions", "with", "H115", "(", "one", "of", "the", "residues", "clamping", "Hyp564", "from", "HIF-1α", "at", "the", "B-interface", "of", "pVHL", ")", "and", "Y112", "." ] } ]
PMC8875242	Alternatively, velpatasvir metabolites produced in hPCIS by CYP3A4 could be responsible for the ABCB1 inhibition seen in that model system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "velpatasvir", "metabolites", "produced", "in", "hPCIS", "by", "CYP3A4", "could", "be", "responsible", "for", "the", "ABCB1", "inhibition", "seen", "in", "that", "model", "system", "." ] } ]
PMC9429973	Known molecular HR genomic (biallelic p53 inactivation, high cancer clonal fraction del17p, HR t(4,14), and cereblon mutation) and transcriptomic (MDMS8 gene signature) features were analyzed, and correlations with OR and progression-free survival (PFS) evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Known", "molecular", "HR", "genomic", "(", "biallelic", "p53", "inactivation", ",", "high", "cancer", "clonal", "fraction", "del17p", ",", "HR", "t(4,14", ")", ",", "and", "cereblon", "mutation", ")", "and", "transcriptomic", "(", "MDMS8", "gene", "signature", ")", "features", "were", "analyzed", ",", "and", "correlations", "with", "OR", "and", "progression-free", "survival", "(", "PFS", ")", "evaluated", "." ] } ]
PMC11670407	Fig. 5OTULIN was required for high GPX4 expression in response to cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "5OTULIN", "was", "required", "for", "high", "GPX4", "expression", "in", "response", "to", "cisplatin", "." ] } ]
PMC11521786	Taking as a reference the current formulation of other vaccine candidates reported by our group, the monovalent HER3-based vaccine candidate (Mv-HER3) includes a combination of Montanide ISA 51 VG and very small size particles (VSSP) as adjuvants (28–30).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taking", "as", "a", "reference", "the", "current", "formulation", "of", "other", "vaccine", "candidates", "reported", "by", "our", "group", ",", "the", "monovalent", "HER3-based", "vaccine", "candidate", "(", "Mv-HER3", ")", "includes", "a", "combination", "of", "Montanide", "ISA", "51", "VG", "and", "very", "small", "size", "particles", "(", "VSSP", ")", "as", "adjuvants", "(", "28–30", ")", "." ] } ]
PMC11718274	Different superscript letters indicates statistical significant difference among the compared untreated control and treated cells at < 0.001.p • F value is the ratio of between and within group variances.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "superscript", "letters", "indicates", "statistical", "significant", "difference", "among", "the", "compared", "untreated", "control", "and", "treated", "cells", "at", "<", "0.001.p", "•", "F", "value", "is", "the", "ratio", "of", "between", "and", "within", "group", "variances", "." ] } ]
PMC11683240	Values of median are given as x-fold of the untreated control (Con), mean ± SEM (n = 9 values from three independent experiments).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "of", "median", "are", "given", "as", "x-fold", "of", "the", "untreated", "control", "(", "Con", ")", ",", "mean", "±", "SEM", "(", "n", "=", "9", "values", "from", "three", "independent", "experiments", ")", "." ] } ]
PMC6114978	Statistical significance determined by two-tailed t-test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "determined", "by", "two-tailed", "t-test", "." ] } ]
PMC11144200	B After co-culture with effector cells and target cells, supernatants were separated and analyzed for secretion of IL-2, IFN-γ, TNF-α, and IL-10 and measured by the ELISA kits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "After", "co-culture", "with", "effector", "cells", "and", "target", "cells", ",", "supernatants", "were", "separated", "and", "analyzed", "for", "secretion", "of", "IL-2", ",", "IFN-γ", ",", "TNF-α", ",", "and", "IL-10", "and", "measured", "by", "the", "ELISA", "kits", "." ] } ]
PMC8041314	More importantly, a great variety of fluorescence dyes has been used to assess the corresponding compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "importantly", ",", "a", "great", "variety", "of", "fluorescence", "dyes", "has", "been", "used", "to", "assess", "the", "corresponding", "compounds", "." ] } ]
PMC11638255	Supernatant was aspirated and pellets were gently resuspended in the respective conditioned media for 30 min at room temperature before centrifuging again at 1000 × g at 20 °C for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supernatant", "was", "aspirated", "and", "pellets", "were", "gently", "resuspended", "in", "the", "respective", "conditioned", "media", "for", "30", "min", "at", "room", "temperature", "before", "centrifuging", "again", "at", "1000", "×", "g", "at", "20", "°", "C", "for", "5", "min", "." ] } ]

PMC11024707

Mi-RNAs are short (∼21 nucleotides) and non-protein-coding RNA molecules that regulate post-transcriptional gene expression .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mi-RNAs", "are", "short", "(", "∼21", "nucleotides", ")", "and", "non-protein-coding", "RNA", "molecules", "that", "regulate", "post-transcriptional", "gene", "expression", "." ] } ]

PMC7841189

Compared with normal thyroid tissue, the expression of LEBP2 at both mRNA and protein levels was significantly higher in human thyroid carcinoma tissues (Fig. 1A and B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "with", "normal", "thyroid", "tissue", ",", "the", "expression", "of", "LEBP2", "at", "both", "mRNA", "and", "protein", "levels", "was", "significantly", "higher", "in", "human", "thyroid", "carcinoma", "tissues", "(", "Fig.", "1A", "and", "B", ")", "." ] } ]

PMC9964654

High-performance liquid chromatography (HPLC) analysis was performed on a Perkin Elmer Series 200 Pump coupled to a Perkin Elmer Series 200 UV-Vis Detector using as eluents H2O with 0.1% of trifluoroacetic acid (TFA) (A) and acetonitrile with 0.1% TFA (B).

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PMC11756907

The results for the ANOVA test were: p < 0.0001, n=3.

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PMC11525028

Dysregulation of ac4C modification and NAT10 impacts the proliferation and apoptosis of myeloma cells, thereby influencing tumor progression.

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PMC6222635

The ratios of these reagents used in the experiment are shown in Table 1.

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PMC11530949

In this study, copper oxide-silver (Ag-doped CuO) NPs were prepared using a reduction method with Ephedra intermedia extract.

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PMC11738017

WGS data were uploaded to the European Genome-phenome Archive (EGA) under the follow study ID: EGAS50000000546.

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PMC10933092

MA is characterized by tRNA and rRNA, which have a major influence on its structure and function owing to the presence of both methyl adducts and a positive charge under physiological conditions (Roovers et al., 2004).

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PMC7823217

In type-I epithelial ovarian cancer type, precursor lesions are clearly defined, whereas in Type-II lesions, malignant cells may arise from the tubal and/or ovarian surface epithelium .

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PMC9429973

Eligibility criteria: 1.

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PMC11476004

The levels of damage in the other group were M (16 dogs) and H (4 dogs).

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PMC10380508

Therefore, very likely inter-regulatory relationships exist between different PAX genes that are expressed in the same RCC cells.

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PMC11026382

DHFR positions are along the horizontal axis; amino acid residues (along the vertical axis) are organized by physiochemical similarity.

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PMC8806312

Univariate Cox regression (UCR) analysis was used to identify genes whose expression was related to the overall survival of patients with OS.

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PMC11321678

By combining these two gene lists, we constructed a putative NTR‐Positive TF regulatory network (Figure 5A).

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PMC6684588

P ≤ 0.001 vs. vehicle; P ≤ 0.001 vs. uninjected (contralateral) TA by one-way ANOVA with Tukey’s adjustment. (

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PMC11306331

Finally, we also tested single and double repeats of mEGFP to probe if condensation dissolution might be a function of cargo protein size.

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PMC9250505

After three washings with PBS, fixed cells were permeabilized with 0.2% Triton X-100/PBS for 5 min and incubated with 5% BSA /PBS for 15 min.

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PMC9920575

These findings suggest that the SCH extract has the potential to selectively kill tumor cells by promoting apoptosis, without harming nontumor cells.

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PMC7171147

e Western blot of pAKT (S473) and CPT1A in ES2 cells cultured in either PBS or COL11A1-coated plates for 48 h and treated with LY294002 (20 µM) for 48 h. GAPDH was used as a loading control.

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PMC9429973

Prospective studies are now needed to evaluate and compare DOACs to the currently recommended antithrombotic drugs for high-risk MPN patients.

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PMC4839679

Staining was performed by adding 50 μL of 0.4% Sulforhodamine B in 1% acetic acid solution to every well and the plate was incubated for 10 minutes at room temperature.

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PMC11767725

These microorganisms are not randomly distributed but are shaped by variations in the skin’s biophysical properties, such as pH, moisture levels, lipid content, and exposure to environmental factors.

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PMC10551595

MTT assay was determined to examine the effect of GinA or GinA/Dexa on ALL cell lines, and patient primary and control MNCs.

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PMC11348300

Image processing included background subtraction and spatial median filtering to eliminate hot pixels and readout noise.

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PMC8481254

To investigate whether CA can inhibit the O-GlcNAcylation and YAP level upregulated by HG, we cultured cells with normal (5.5 mM) or high (25 mM) concentrations of glucose and treated 25 mM glucose-treated cells with CA.

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PMC9429973

The overall mortality was 15% and the COVID-19 related mortality 10%.

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PMC11474209

The remaining 2 % of the world's water supply is freshwater, of which 0.36 % is found underground in aquifers and wells, and 1.6 % is locked in glaciers and polar ice caps.

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PMC9429973

Interestingly, RUNX2 and IGFBP7, high-risk markers in T-ALL,2,3 were aberrantly expressed in this subset of T-ALL.

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PMC11718809

Details of the primers are presented in Table S4.

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PMC11291697

In humans, serine deficiency is associated with severe neurological abnormalities including developmental delay, intellectual disability, microcephaly and seizures , while several studies detected low levels of glycine and D-serine in the plasma and cerebrospinal fluid of individuals with schizophrenia .

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PMC11300639

a Analysis of the TCGA-KIRC dataset after sub-dividing the RNF26 into high or low expression group.

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PMC5925824

PD-L1 expression can also be up-regulated in the tumor microenvironment as a result of immune activation and production of pro-inflammatory cytokines such as interferon-gamma (IFNγ), contributing to the establishment of an “adapted” T-cell immunosuppressive milieu .

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PMC11617590

Once in the cytosol, β‐catenin is transported to the nucleus, where it interacts with the T‐cell factor/lymphoid enhancing factor (TCF), a transcription factor, and promotes the transcription of genes that regulate cell proliferation, differentiation, apoptosis, migration, infiltration, and tissue homeostasis .

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PMC11673902

Cell separation usually relies on biochemical and biophysical markers.

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PMC11727145

As regards the mitigation of donor-to-donor variability, the possibility of preparing several tissue samples from the same large tissue donation enabled the conducting of an experimental series with a single donor.

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PMC9429973

Interestingly, we reported an accumulation of Fe in the mitochondria, correlating with a 2-fold increase in mitochondrial reactive oxygen species (ROS) content.

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PMC11792740

This process facilitated Th17 inflammation, promoted IL-17 A-induced CD8 + T-cell exhaustion, and drove colorectal carcinogenesis .

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PMC9429973

Related AEs ≥ Grade 3 (≥ 5%) were: lipase elevation (15%), rash (combined listings) (9%), and amylase elevation (7%).

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PMC10994876

Previous studies have indicated that YAP has the ability to interact with p73, a transcription factor associated with p53.

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PMC11632064

Spearman correlation coefficients between perturbation effects (DepMap) and transcript levels (CCLE) were calculated using Prism (GraphPad Software).

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PMC10728535

The findings revealed expression variation in several proteins participating in cell adhesion including MFAP4, PCDH19, CDH2, CDH10, NRXN1, COL4A6, COL15A1, PIP5K1B, EPHA3, BOC, and CD36.

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PMC6450504

Briefly, the cells were seeded at a density of 100,000 cells/well in 12-well plates 24 h prior to the experiment and then treated with Rhod-PE labeled 0%, 0.1%, and 0.5% PEIPOS in serum-complete medium.

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PMC11593084

PMab-117-mG2a exerted potent antitumor effects in human xenograft model, and is expected to be applicable to human cancer treatment by generating a humanized mAb, ADC, and CAR-T.

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PMC9429973

Aims: to study the microenvironment and immune checkpoint of MDS by FSFCM.

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PMC6892818

Results are typical of tive independent experiments and are presented as background-corrected relative luminescence units (RLU).

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PMC9429973

1 patient with AITL was in CR at the time of alloHSCT and remains alive, relapse and GVHD free 28 months after alloHSCT while 1 patient in PR at the time of alloHSCT is alive in CR, relapse/GVHD free 6 years later.

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PMC11695546

The micro-dilution broth procedure was applied to test MIC of the specimens being studied by employing nutritional broth for bacterial.

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PMC8041314

In short, Hoechst 33342 and daunorubicin are substrates of ABC transporters that passively diffuse into the cells and become extruded by the respective ABC transporter.

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PMC9429973

Mild peripheral blood lymphocytic subsets abnormalities were observed in ¼ of the patients, particularly in LO, and mild reduction of serum immunoglobulin class levels in ¼ of the patients, without difference between no LO/LL and LO.

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PMC11767725

Follicular rupture releases keratin and sebum into the dermis, triggering a robust inflammatory response.

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PMC9429973

Methods: The patients are randomized 1:1 between NIL and IM according to Sokal risk score (high versus intermediate/low risk) and country.

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PMC11462673

Two days after puromycin selection, both transfected control cells and LDB1 knockdown cells were collected.

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PMC8143558

The nomenclature of these plants is usually based on their soapy qualities, such that even the common names usually include “soap” e.g., soap aloe, soapwort, soap tree, soap berry, soap bark, and soap dogwood.

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PMC10907726

It is essential to recognize the limitations inherent in our investigation, which focused narrowly on the 143B osteosarcoma cell line.

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PMC11468365

is shown in Eq. (17).17[12pt] $$^=1-_)},$$2=1-MSEvarya,where18[12pt] $$var(_)=^_^- }_^)}^}.$$=∑i=1nyai-y¯ai2n.

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PMC9503541

The most active fractions were F15-16C and F15-16D.

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PMC10882807

Furthermore, the distribution of hsa_circ_0005397 was explored via cell fractionation, with hsa_circ_0005397 mostly located in the cytoplasm (Fig. 1G).

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PMC11541409

The underlying resistance mechanism is that growth factor-activated RTKs (FGFR, MET) share the MAPK/ERK pathway with KIT/PDGFRA, and activation of these RTKs by ligands supports survival and proliferation of GIST cells in the context of TKI treatment.

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PMC11471176

However, it is crucial to acknowledge the absence of conclusive evidence substantiating this concept thus far.

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PMC11656380

Animal experimental procedures were performed according to guidelines for the Institutional Animal Care and Use Committee of Sojo University.

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PMC11750712

The bound (TRBC1) fraction was collected by following the protocol as stated.

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PMC11678130

The cells presented normal proliferation during the performed experiments.

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PMC11723947

a Representative dot-plots showing 21 days after engraftment the percentage of WT and HP1γ KO TCR Vβ6 Tconv producing IFN-γ and IL-17A.

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PMC10237474

no. A2916801, Thermo Fisher Scientific).

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PMC11564405

For example, high levels of CXCL9 and CXCL10 are associated with increased Th1 cell infiltration; CCL5 promotes the recruitment of CD8 + T cells; heightened CX3CL1 is correlated with augmented TILs .

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PMC11703992

Notably, the expression of all these inflammatory factors in DDIT4-OE-PMA were significantly lower than Blank-PMA group, which might indicate that DDIT4 triggers low-intensity inflammation in active T cells.

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PMC11585565

These findings suggest that the rapid degradation rates and loss of Mg efflux activity associated with these variants may serve as potential pathogenic mechanisms underlying the phenotypes of Jalili syndrome.

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PMC11721587

Overexpression of Ulk3 in NIH3T3 cells also promoted Ulk3 maturation, which depended on its kinase activity, SUMOylation, and SIM (Fig. 6H).

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PMC11730000

It was considered statistically significant when p < 0.05.

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PMC11411004

Cells harvested on day 7 were included in the analysis.

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PMC11731614

The enrichment analysis of the predicted protein targets of let-7 and miR-23 both revealed predicted KEGG pathways related to ‘Axon Guidance,’ suggesting a possible role of KDEV small RNAs on keratinocyte-to-neuron communication.

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PMC8584319

Protein synthesis decreased in thapsigargin (Tg)-treated wild-type MEFs but not in Tg-treated mutant MEFs; however, both wild-type and mutant MEFs treated with AZD8055 showed a significant decrease in protein synthesis (Figure 1c,d).

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PMC11489351

Cells were trypsinized and plated (80,000 cells/dish, MCF10A; 50,000 cells/dish, RPE) in separate 3.5 cm imaging dishes for each condition (Matsunami, Dd35-14-1.5-U) and returned to the incubator for 24 h. Cells were then treated with pHi-manipulation media, and dishes were returned to the incubator overnight.

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PMC6803987

To explore the anti-hepatitis B virus effect of esculetin, a congenitally infection model of duck hepatitis B was used to explore the effect of different doses of esculetin on DHBV.

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PMC11434983

H NMR (500 MHz, DMSO-d6) δH 9.7 (1H, H-6), 9.4 (1H, H-1), 8.8 (1H, H-11), 8.6 (1H, H-14), 8.3 (1H, H-4), 8.2 (1H, H-3), 8.1 (1H, H-20), 8.0 (1H, H-8), 7.9 (1H, H-9), 7.8 (1H, H-2), 7.7 (1H, H-16), 7.5 (1H, H-17), 7.5 (2H, H-18), 7.3 (3H, PPh3 para), 7.2 (6H, PPh3 meta), and 7.1 (6H, PPh3 ortho).

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PMC11577421

Binding regions of heparin and heparan sulfate disaccharides to native albumin. (

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PMC11225860

depicts H&E stain from a vehicle control treated mouse.

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PMC7868205

According to Bragg’s reflection, the estimated average size of the particles was 31.12 nm.

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PMC11484188

Effective nanoparticles, liposomes or viral vectors can be designed to deliver miRNAs or anti-miRNAs to tumor cells.

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PMC5308810

To demonstrate the therapeutic merits of targeting CXCR4, we evaluated the cytotoxicity of CXCR4-KLA alone or in combination with other cytotoxic agents toward A2780, A2780/ADR, and SKOV3.

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PMC9386809

Cells were seeded in a 96 well plate, 10,000 cells in each well, and incubated overnight at 37 °C in a CO2 incubator.

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PMC11354239

Acting separately or together, these factors could lead to resistance to therapeutic mAbs, a substantial decrease in therapeutic efficacy, and a high relapse rate .

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PMC10578720

Inspired by these findings, we investigated whether HBV could regulate SIRT3 expression in macrophages through the TLR2-NF-κB-PGC-1α axis.

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PMC11566417

The other luminal marker assessed, ERα , trended downwards between p10 and p20 in primary as well as immortalized MDECs irrespective of passage, albeit this did not reach a statistical significance difference (Fig. 2a and Supplemental Fig. 2).

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PMC9429973

Median follow-up was 6 mo.

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PMC9429973

Hematologic malignancy (34.1%, n=168) was the most common type of SPM, followed by stomach cancer in 49 (9.9%) patients, lung cancer in 44 (8.9%) patients, and colon cancer in 31 (6.3%) patients.

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PMC7171147

The role of fatty acids as substrates that induce chemoresistance is less explored compared to glucose or glutamine.

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PMC8978939

More precisely, while lining the floor of the β-domain in native pVHL, this flexibilized region constitutes a hydrophobic patch from where P138 establishes direct hydrogen-bonding interactions with H115 (one of the residues clamping Hyp564 from HIF-1α at the B-interface of pVHL) and Y112.

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PMC8875242

Alternatively, velpatasvir metabolites produced in hPCIS by CYP3A4 could be responsible for the ABCB1 inhibition seen in that model system.

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PMC9429973

Known molecular HR genomic (biallelic p53 inactivation, high cancer clonal fraction del17p, HR t(4,14), and cereblon mutation) and transcriptomic (MDMS8 gene signature) features were analyzed, and correlations with OR and progression-free survival (PFS) evaluated.

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PMC11670407

Fig. 5OTULIN was required for high GPX4 expression in response to cisplatin.

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PMC11521786

Taking as a reference the current formulation of other vaccine candidates reported by our group, the monovalent HER3-based vaccine candidate (Mv-HER3) includes a combination of Montanide ISA 51 VG and very small size particles (VSSP) as adjuvants (28–30).

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PMC11718274

Different superscript letters indicates statistical significant difference among the compared untreated control and treated cells at < 0.001.p • F value is the ratio of between and within group variances.

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PMC11683240

Values of median are given as x-fold of the untreated control (Con), mean ± SEM (n = 9 values from three independent experiments).

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PMC6114978

Statistical significance determined by two-tailed t-test.

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PMC11144200

B After co-culture with effector cells and target cells, supernatants were separated and analyzed for secretion of IL-2, IFN-γ, TNF-α, and IL-10 and measured by the ELISA kits.

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PMC8041314

More importantly, a great variety of fluorescence dyes has been used to assess the corresponding compounds.

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PMC11638255

Supernatant was aspirated and pellets were gently resuspended in the respective conditioned media for 30 min at room temperature before centrifuging again at 1000 × g at 20 °C for 5 min.

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