Datasets:
OTAR3088
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BioData-CellLine_annotated

Dataset card Data Studio Files
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PMC11739504
The protein content was measured using the BCA method.
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PMC11564322
sc-23900), and PVDF membrane with 0.45-µm pore size were purchased from Santa Cruz Biotechnology (Santa Cruz, USA).
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PMC11629192
During follow-up, all patients’ symptoms were stable.
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PMC10988555
A NZYColour Protein Marker II (NZYTech) was used as a molecular weight marker.
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PMC10667689
Several studies reveal the dependence of AML cells, particularly leukemic stem cells (LSCs), on fatty acid oxidation (FAO) (16).
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PMC8358006
Specific transcription outputs could be contained in the spread of epigenetic modifications over a genomic locus.
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PMC6114978
The above paradigm focuses on post-translational mechanisms by which the Hippo kinases, TAZ, and YAP can be regulated.
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PMC11470381
Measure transfection efficiency using flow cytometry (cells showing at least 30% transfection efficiency were used for downstream imaging).
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PMC11337594
Ns: not significant, p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 As illustrated in Fig. 3A and B, treatment with TER resulted in an elevation in the expression of the apoptosis-related genes BAX and FAS at both the RNA and protein levels in A375 cells.
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PMC11757131
Further tests were conducted to determine whether the synthesized fatty acids increased oxidation to provide energy for cell proliferation.
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PMC9429973
B. Marques, A. Roque, L. Ruzickova, J. P. Carda, M. Gomes, A. B. Sarmento Ribeiro, C. Geraldes Clinical Hematology Department, Centro Hospitalar e Universitário de Coimbra; Laboratory of Oncobiology and Hematology and University Clinic of Hematology; Coimbra Institute for Clinical and Biomedical Research (iCBR) area of Environment Genetics and Oncobiology (CIMAGO); Center for Innovative Biomedicine and Biotechnology; Institute of Physiology; Clinical Academic Center of Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal Background: Autologous hematopoietic stem cell transplantation (ASCT) is the current standard of care for younger patients (pts) with multiple myeloma (MM), improving overall survival (OS) and progression free survival (PFS).
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PMC11224020
Together, these results suggest that the response of DCs to shape changes requires WASp and ARP2/3 activity to allow nuclear accumulation of cPLA2 and subsequent upregulation of CCR7 expression.
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PMC8427838
Experimental data were subjected to Student t-test or One-way analysis of variance, where appropriate, with representation of at least three independent experiments.
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PMC9429973
The majority of patients showed an intermediate ELN genetic risk, while adverse ELN risk was found in 39% of treatment-naïve patients and 32% of R/R group.
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PMC9429973
Quality of life was also similar in both arms.
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PMC6934009
A microplate reader was used for the measurement of absorbance of each plate at 490 nm.
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PMC7305184
Data on CTRL + EP is shown in supplementary file, Fig. S3.
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PMC11687663
Its involvement in cancer is characterized by both anti-tumorigenic and pro-tumorigenic effects, with outcomes varying based on tissue type and specific cellular contexts.
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PMC8010066
however, no increase was observed in the PA-4.
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PMC11453018
Dasatinib, a tyrosine kinase inhibitor, functions by inhibiting SRC or RTKs, consequently affecting the PI3K/AKT pathway .
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PMC11394386
Subsequently, we evaluated the activation of the PI3K/AKT pathway and the transcriptional activity of HIF1α upon inhibition of HOTAIR, which resulted in a decrease in HIF1α transcriptional activity (Figure 3C).
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PMC2614416
Two independent sets of bioinformatics calculations that employ two BLAST program versions, and searched different sets of databases, arrived at essentially the same conclusion – that oxidoreductases are down-regulated in HepG2 cells by an average of 57%, when compared to normal human liver tissues.
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PMC10887351
In addition, it has been shown the role of exercise in cardio-protection , and it has been proved that β3-ARs have a mediator effect, particularly in a setting of cardiac I/R injury .
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PMC11525028
Scale bars: 50 μm (left), 25 μm (right).
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PMC11700340
Linagliptin can induce cell death by inhibiting the phosphorylation of Rb and the production of Bcl 2.
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PMC10747139
The therapeutic potential of Ru(II)–arene RAPTA-type compounds (PTA = 1,3,5-triaza-7-phosphaadamantane or 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine) has been thoroughly investigated, thus owing to the excellent antimetastatic property of the initial candidate RAPTA-C [Ru(η-p-cymene)Cl2(PTA)] .
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PMC11365983
A collaborative effort encompassing clinicians and researchers at multiple institutions, identified 41 individuals with FOXC1 mutation or copy number variation.
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PMC11451940
Moreover, the time-dependent cytotoxicity studies revealed that a significant increase in cytotoxicity between 24 and 48 h proceeds for zinc(ii) complexes 6 and 7, from IC50 > 50 M (24 h) to ca.
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PMC11612508
To investigate the effect of magnetic fields on drug release from the magnetic microspheres, the experimental setup described in our previous work was utilized.
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PMC9429973
Together, these results demonstrated the immunoregulatory effect of BMP2 on the phenotype and function of γδ T cells in AML microenvironment.
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PMC11699465
Live cell imaging to show the GFP signal in HEK293 cells with TMEM199-GFP plasmid transfection. (
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PMC9429973
Summary/Conclusion: We demonstrate that the current membership of INHERENT has the potential to reach this sample size target.
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PMC9429973
Enrollment continues, with data for Waldenström macroglobulinemia and treatment-naïve CLL/SLL cohorts forthcoming.
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PMC11190538
Furthermore, the nanophytosome C-phycocyanin yoghurt 300 mg had higher overall acceptance and showed no significant difference from the control yoghurt.
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PMC10631132
Embryoid body-based differentiation yielded CD45, CD14, CD11b subpopulations which in turn differentiated into osteoclasts which demonstrated TRAP positivity, Cathepsin K expression and mineral resorptive capabilities.
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PMC7759933
The staining was performed according to with modifications.
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PMC11539788
A straight scratch was created in the bottom of the plate using a sterilized pipette tip (10 µl).
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PMC11680049
In this variant, by the 17th to 20th day of cultivation, 100% callus formation was noted, which exhibited a yellowish and beige-green color, high growth rates, and remarkable viability (Figure 5).
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PMC11525028
Collectively, our findings indicate that NAT10 regulates ATF4-mediated ASNS transcription and Asn biosynthesis in osteosarcoma.
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PMC10568263
0.9 g C2H5NS, 10 mL ethanol, 1.00 g (NH4)6Mo7O24·4H2O, and 10 mL C5H9NO were dissolved in 30 mL of deionized (DI) water, stirring for 30 min to form a homogeneous solution.
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PMC9429973
There was a correlation between CD200 expression and CR rate in patients of moderate risk, but there was no statistical significance.
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PMC11794588
There was a minimum 6-h pause between each sonication to allow the suspension to reach room temperature.
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PMC9444294
We also demonstrate nuclear staining of SS18-SSX in synovial sarcoma cells using immunofluorescence, and visualize the interaction between SS18-SSX and the BAF complex member BRG1 through a proximity ligation assay.
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PMC9164404
Strating form cisplatin, a hydrophobic Pt(IV) prodrug (CisPt(IV)) with two hydrophobic aliphatic chains was synthesized, and further encapsulated with a drug carrier, human serum albumin (HSA), to form nanoparticles, namely AbPlatin.
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PMC11045125
Similar results were obtained using both Myc vectors.
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PMC11665584
To investigate a possible role of the transcription factor PITX1 in programming an oral epithelial lineage, we generated Tet-On, TRE-Pitx1/Krt5-rtTA transgenic mice (14).
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PMC5916734
The eluate was diluted fourfold with water, loaded into a column packed with the Capto Q sorbent and equilibrated with a 50 mM Tris-HCl solution, pH 8.0; 100 mM NaCl; washed with a 50 mM Tris-HCl solution, pH 8.0; 200 mM NaCl; and eluted stepwise with the following solutions: 50 mM Tris-HCl pH 8.0; 10 mM CaCl2 , and 100–500 mM NaCl.
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PMC7192625
Once the data have been assigned to nodes in the network, ChAseR performs correlation analyses.
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PMC11388384
As a result, the transition rates between the confined and free populations determine the effective diffusion rate of a morphogen.
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PMC10604092
Notably, the SLC-transplanted rats exhibited significant muscle loss in all examined skeletal muscles, including those on the carcass, and the gastrocnemius, soleus, and quadriceps, and adipose tissue loss, including epididymal, perinephric, and mesenteric adipose tissues (Figure 1D,E; p < 0.01).
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PMC11562028
Treatment was initiated and set as the experiment day 0 when the tumor volume of most mice reached ∼50–70 mm (volume (mm) = (length × width)/2).
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PMC11599565
Labelled cells were cytometrically measured using a CytoFLEX Research Cytometer B5-R5-V5 (Beckman Coulter, Krefeld, Germany).
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PMC11641630
In this study, we report that mycobacteria treatment exerts an anti-oncogenic effect on tumor migration and progression, depending on the specific mycobacterium used and the differentiation status of bladder cancer (BC) cells.
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PMC9429973
Median follow-up time was 3 years in AAs and 4 years in whites.
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PMC11750712
In vitro data were analyzed with GraphPad Prism v10.1.2 (GraphPad software).
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PMC9429973
No pts experienced grade 4 or higher cardiac conduction TEAEs.
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PMC10197932
Dichlorodihydrofluorescein diacetate (DCFH-DA) cod.
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PMC11011837
Inositol phosphate metabolism is another pathway exhibiting variations in Molt-4, likely linked to the higher abundance of myo-inositol in Molt-4 cells compared to the other lines.
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PMC10048572
The Jurkat-O1 sample was divided into three equal parts, in the first subclones 1–127, in the second subclones 128–254, and in the third subclones 255–381.
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PMC3035438
This method presents the great advantage of allowing the selection and production of whole chimeric IgG mAbs in a single step, without the need of further manipulation such as making recombinant proteins from phage DNA.
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PMC11768927
This anti-tumor effect was further enhanced by coupling the treatment with gemcitabine.
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PMC9243326
Then, functional classification of the unigenes was performed using the WEGO software (Ye et al., 2006).
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PMC11790971
Each dataset was randomly partitioned into a training set (70% of cells) and a test set (30% of cells) ten times for the 10-fold Monte Carlo cross-validation.
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PMC6267596
41 peptides were significantly (p≤0.05) increased in phosphorylation of alisertib treated (50nM, 4 days) 8n cells vs. control, of these the top 20 peptides are listed (Table 1a).
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PMC11144382
In addition, there was also no significant difference in GFAP expression in 4 of the 5 MSS fibroblast cell lines, when compared with unrelated controls, while the MSS c.1090dupG was associated with reduced GFAP expression (-12 fold, n = 4, P <0 .05) at the mRNA (Figure S3C) and protein (-24 fold, n = 4, P <0 .01, Figure S3D–F) levels, when compared with the unrelated controls.
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PMC11537649
After electrophoresis, membrane transfer, incubation of primary antibody, membrane washing, incubation of secondary antibody, and membrane washing, the enhanced chemiluminescence luminescent solution was used for luminescence development.
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PMC11806818
Additionally, the dual-channel detection capability of dual-mode sensors allows for cross-validation of results, thus ensuring greater accuracy and providing more comprehensive information about the sample.
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PMC11568601
The transwell chambers with 8.0 μm pore (Corning Costar, USA) were placed into 24-well plates with or without 60 µL of Matrigel solution (3 mg · mL) added to the upper chamber for invasion and migration assay, respectively.
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PMC11794568
Transwell invasion assay was used to assess the invasive ability after addition of rotenone to CRIP1-silenced cutaneous melanoma cells (scale bar is 50 μm).
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PMC11544122
b Whole cell lysates from β-arr1 KO, β-arr2 KO, or β-arr1/2 DKO were analyzed by immunoblot for β-arr1 and β-arr2 using an antibody that recognizes both isoforms or for GAPDH, using here as a loading control.
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PMC11319300
No active promoter state can be seen over the TSS of MYEOV as evidenced by the absence of H3K4me3 and H3K27ac sharp peaks in this region, suggesting that MYEOV enhancer activity might be independent of MYEOV gene transcription in healthy B cells (Figure 1; Supplementary Figure S1).
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PMC11476004
The differences in SCE frequency were statistically significant.
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PMC9429973
The main category within YOUNG patients was AML with mutated NPM1 (19.4%) and in the OLD group was AML-MRC (45.2%).
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PMC11352311
Similarly, AXP-3019, a 3-bromo-isoxazoline derivative, inhibits the proliferation of pancreatic cancer cells by targeting and inhibiting GAPDH .
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PMC10900886
ANA, Arthrobacter ureafaciens neuraminidase; BLCL, B-lymphoblastoid cell line.
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PMC8978939
We showed that both pVHL variants maintain their ability to form a VBC complex, although it is apparently formed at a lower rate: P138R appears to bind less Elongin B and C, while L163R appears to bind Elongin C appropriately but less Elongin B. These results are in agreement with other groups’ findings, since the majority of inherited VHL mutations are defective in Elongin B and C binding (62–65).
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PMC10203589
In addition, by chromatin immunoprecipitation assay (ChIP) and quantitative ChIP assay analysis, β-catenin was associated with the promoter of proliferation-related genes (CCND2, CDK2, and Ki67) as well as migration-related genes (TGF-β, MMP-9, and MMP-2) and EMT markers (N-cadherin, vimentin, Snel-1, and Vimentin).
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PMC9429973
No statistically significant decrease of PRBC transfused was found between the intervals 5-16weeks and 13-24 weeks compared to the initial interval of 1-12 weeks.
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PMC11252033
However, the fact that CryZ silencing mimics the ASA effect at a similar extent suggests that inhibition of CryZ mRNA binding by means of ASA may play a major role.
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PMC11706491
Changes in the length of the cell cycle, due to faster or slower progression, result in corresponding decreases or increases in cell size.
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PMC10212663
CI, confidence interval; DSS, disease‐free survival; HR, hazard ratio; OS, overall survival; PFS, progression‐free survival; RANKL, receptor activator of nuclear factorκB ligand; TCGA, The Cancer Genome Atlas Interestingly, it was suggested from the work by Faget et al. that KRAS‐mt LUAD expressed higher levels of RANKL than KRAS‐wt ones.
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PMC7757104
High levels of P-gp have been demonstrated to induce TMZ resistance in a glioblastoma (GBM) model (36).
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PMC11593713
The cytosolic selenium-dependent GPx is ubiquitously expressed throughout the body .
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PMC9429973
Stage was III/IV in 34 pts (63%).
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PMC8662250
Magnification 20× (scale bar, 20 μm).
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PMC11496491
GO enrichment analysis results show the top 20 terms that are most significant in terms of cell components.
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PMC9429973
Guidelines should aim at standardizing and improving communication with patients about gonadotoxicity and at standardizing gamete preservation procedures particularly for women in light of the available and future techniques.
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PMC9856122
Tetrandrine from the category of bis-benzylisoquinoline alkaloids of isoquinoline alkaloids has been reported for immunomodulation and anti-inflammatory activities.
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PMC11655536
However, whether HA could inhibit MM remains unknown.
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PMC9503685
For this reason, it is important to investigate the effects of antimicrobials not only on extracellular bacteria but also on intracellular bacteria.
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PMC11536589
Furthermore, the development of resistance to KRAS inhibitors in other types of malignancies is also quite feasible.
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PMC9429973
Under EZH2i, platinum was less present in the cells proven by inductive coupled plasma mass spectrometry.
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PMC10808409
The saturation solubility of TPGS mixed micelles was approximately 21.5 times that of free FA in water.
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PMC9429973
Febrile neutropenia was the most frequent toxicity (35%) followed by hepatotoxicity (28%) and QTc prolongation (16%).
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PMC8992508
An investigation on the type of interaction with the BCRP substrates Hoechst 33342 and pheophorbide A of compound 72 and Ko143(5) revealed that both compounds showed a competitive interaction with the substrate Hoechst 33342.
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PMC11659734
Human lymphocytes, primary non‐transformed cells and the human hepatocyte cell line HepG2 cultivated in 3D were employed for the experiments.
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PMC11694109
The success of these treatments is partly attributed to a deep understanding of the underlying immunobiology of B-cell lineage lymphomas.
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PMC11267830
LightCycler® 480 SYBR Green I Master Mix (Roche, 04707516001) was used.
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PMC11307990
Subsequently, the mica surface was washed with ultrapure water and dried with a nitrogen gun.
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PMC5261804
Drug sensitivities were derived from CCLE AUC data.
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