Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC11451940
IR (ATR; cm): 3059, 2962, 2909, 2878, 2852, 1622, 1585, 1547, 1432, 1352, 1277, 1242, 955, 842, 765, 737, 701, 666, 631, 546, 466, 501, 546, 436.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IR", "(", "ATR", ";", "cm", "):", "3059", ",", "2962", ",", "2909", ",", "2878", ",", "2852", ",", "1622", ",", "1585", ",", "1547", ",", "1432", ",", "1352", ",", "1277", ",", "1242", ",", "955", ",", "842", ",", "765", ",", "737", ",", "701", ",", "666", ",", "631", ",", "546", ",", "466", ",", "501", ",", "546", ",", "436", "." ] } ]
PMC11116779
Apoptosis was measured by Annexin-FITC/PI assay by flow cytometry after 96 h of incubation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptosis", "was", "measured", "by", "Annexin-FITC/PI", "assay", "by", "flow", "cytometry", "after", "96", "h", "of", "incubation", "." ] } ]
PMC9635307
Thus, CEACAM1 may support the homeostatic proliferation of B cells, which does not require BCR signaling, when they are immature.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "CEACAM1", "may", "support", "the", "homeostatic", "proliferation", "of", "B", "cells", ",", "which", "does", "not", "require", "BCR", "signaling", ",", "when", "they", "are", "immature", "." ] } ]
PMC11476264
The docking results show that the Z-dock docking fraction of FBXO11 and ZEB1 is 1742.563.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "docking", "results", "show", "that", "the", "Z-dock", "docking", "fraction", "of", "FBXO11", "and", "ZEB1", "is", "1742.563", "." ] } ]
PMC11594588
Platelet mitochondria may serve as an important biomarker in neurodegenerative diseases that, either through genetic defects or environmental stress, lead to apoptosis and premature platelet death .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Platelet", "mitochondria", "may", "serve", "as", "an", "important", "biomarker", "in", "neurodegenerative", "diseases", "that", ",", "either", "through", "genetic", "defects", "or", "environmental", "stress", ",", "lead", "to", "apoptosis", "and", "premature", "platelet", "death", "." ] } ]
PMC9429973
Whether immune dysfunction plays a role in development of the disease or is due to the premalignant MBL and MGUS warrants further investigations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whether", "immune", "dysfunction", "plays", "a", "role", "in", "development", "of", "the", "disease", "or", "is", "due", "to", "the", "premalignant", "MBL", "and", "MGUS", "warrants", "further", "investigations", "." ] } ]
PMC11490153
The solutions were poured into a quartz cell and situated in the hole of the apparatus for analysis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "solutions", "were", "poured", "into", "a", "quartz", "cell", "and", "situated", "in", "the", "hole", "of", "the", "apparatus", "for", "analysis", "." ] } ]
PMC6450504
Liposome formulations were incubated at 37 °C under mild agitation for 4 hours for stable postinsertion of bPEI-PE into the lipid bilayer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Liposome", "formulations", "were", "incubated", "at", "37", "°", "C", "under", "mild", "agitation", "for", "4", "hours", "for", "stable", "postinsertion", "of", "bPEI-PE", "into", "the", "lipid", "bilayer", "." ] } ]
PMC9412887
In recent years, natural killer (NK) cell-related immunotherapy has been revealed as an alternative to ICB-based immunotherapy or vaccine-based immunotherapy .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", "natural", "killer", "(", "NK", ")", "cell-related", "immunotherapy", "has", "been", "revealed", "as", "an", "alternative", "to", "ICB-based", "immunotherapy", "or", "vaccine-based", "immunotherapy", "." ] } ]
PMC9429973
The 4-year PFS was 71% for both pts with MYD88 and MYD88 genotypes (p=0.44), Figure 1A.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "4-year", "PFS", "was", "71", "%", "for", "both", "pts", "with", "MYD88", "and", "MYD88", "genotypes", "(", "p=0.44", ")", ",", "Figure", "1A", "." ] } ]
PMC11126803
Previous reports have shown that ERβ, but not ERα, could play important roles in RCC progression (1, 25, 35).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "reports", "have", "shown", "that", "ERβ", ",", "but", "not", "ERα", ",", "could", "play", "important", "roles", "in", "RCC", "progression", "(", "1", ",", "25", ",", "35", ")", "." ] } ]
PMC11531735
To assess this, we employed the well-established MDA-MB-231 cell model of TNBC expressing fluorescent markers HER2/GFP and RFP/Luciferase, creating an experimental metastasis model.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "this", ",", "we", "employed", "the", "well-established", "MDA-MB-231", "cell", "model", "of", "TNBC", "expressing", "fluorescent", "markers", "HER2/GFP", "and", "RFP/Luciferase", ",", "creating", "an", "experimental", "metastasis", "model", "." ] } ]
PMC11713609
Moreover, the tumor-suppressive role of PHLDA2 has been implicated in different mouse tumor models, including the genetically well-defined lymphoma model and the pharmacologically induced liver cancer model (Yang et al., 2024).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "tumor-suppressive", "role", "of", "PHLDA2", "has", "been", "implicated", "in", "different", "mouse", "tumor", "models", ",", "including", "the", "genetically", "well-defined", "lymphoma", "model", "and", "the", "pharmacologically", "induced", "liver", "cancer", "model", "(", "Yang", "et", "al.", ",", "2024", ")", "." ] } ]
PMC11599565
After baking, the sections were deparaffinized in two changes of xylene-substitute (Thermo Scientific, London, UK) solution for 10–15 min and rehydrated in a series of graded ethanol solutions (100%, 100%, 95%, 70%, 50%) for 3 min each.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "baking", ",", "the", "sections", "were", "deparaffinized", "in", "two", "changes", "of", "xylene-substitute", "(", "Thermo", "Scientific", ",", "London", ",", "UK", ")", "solution", "for", "10–15", "min", "and", "rehydrated", "in", "a", "series", "of", "graded", "ethanol", "solutions", "(", "100", "%", ",", "100", "%", ",", "95", "%", ",", "70", "%", ",", "50", "%", ")", "for", "3", "min", "each", "." ] } ]
PMC3734024
Given that FasL B cells shared at least some phenotypic similarities with IL-10-producing B cells, we sought to determine whether these were discrete or overlapping cell populations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "that", "FasL", "B", "cells", "shared", "at", "least", "some", "phenotypic", "similarities", "with", "IL-10-producing", "B", "cells", ",", "we", "sought", "to", "determine", "whether", "these", "were", "discrete", "or", "overlapping", "cell", "populations", "." ] } ]
PMC5386478
Anti-mouse and anti-rabbit IgG peroxidase or fluorescein isothiocyanate (FITC)-conjugated antibodies and chemical reagents were from Sigma-Aldrich (St Louis, MO, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-mouse", "and", "anti-rabbit", "IgG", "peroxidase", "or", "fluorescein", "isothiocyanate", "(FITC)-conjugated", "antibodies", "and", "chemical", "reagents", "were", "from", "Sigma-Aldrich", "(", "St", "Louis", ",", "MO", ",", "USA", ")", "." ] } ]
PMC11488203
A comparison of MSC-derived control and taxol exosome miR expression levels revealed 86 unique miRs in the control MSC while 64 miRs exclusively appeared in exosomes of the corresponding taxol-treated MSC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "comparison", "of", "MSC-derived", "control", "and", "taxol", "exosome", "miR", "expression", "levels", "revealed", "86", "unique", "miRs", "in", "the", "control", "MSC", "while", "64", "miRs", "exclusively", "appeared", "in", "exosomes", "of", "the", "corresponding", "taxol-treated", "MSC", "." ] } ]
PMC11765988
Elevated oxidative stress markers, such as oxidatively damaged macromolecules and lipid peroxidation products, have been reported in sarcoidosis patients, generating interest in non-invasive predictive tools for disease outcomes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Elevated", "oxidative", "stress", "markers", ",", "such", "as", "oxidatively", "damaged", "macromolecules", "and", "lipid", "peroxidation", "products", ",", "have", "been", "reported", "in", "sarcoidosis", "patients", ",", "generating", "interest", "in", "non-invasive", "predictive", "tools", "for", "disease", "outcomes", "." ] } ]
PMC10165258
After the loading, the chips were kept immersed in PBS in the CO2 incubator.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the", "loading", ",", "the", "chips", "were", "kept", "immersed", "in", "PBS", "in", "the", "CO2", "incubator", "." ] } ]
PMC6268318
The plant extracts were selected for this work and the references found in the search were later consulted for details on the models or mechanisms.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plant", "extracts", "were", "selected", "for", "this", "work", "and", "the", "references", "found", "in", "the", "search", "were", "later", "consulted", "for", "details", "on", "the", "models", "or", "mechanisms", "." ] } ]
PMC11474209
MC-LR exposure results in cellular damage, hepatotoxicity, and genotoxicity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MC-LR", "exposure", "results", "in", "cellular", "damage", ",", "hepatotoxicity", ",", "and", "genotoxicity", "." ] } ]
PMC11767793
a: in DI water.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", ":", "in", "DI", "water", "." ] } ]
PMC9429973
For immunostaining of MDSCs’ mitochondria, human MDSCs were generated in vitro, stained with MitoTracker Red and anti-CD33 antibody.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "immunostaining", "of", "MDSCs", "’", "mitochondria", ",", "human", "MDSCs", "were", "generated", "in", "vitro", ",", "stained", "with", "MitoTracker", "Red", "and", "anti-CD33", "antibody", "." ] } ]
PMC4485786
SPECT/CT biodistribution studies with I-labeled NHS-IL12 revealed significant in vivo enrichment of NHS-IL12 inside the sarcoma microenvironment (Fig. 2A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SPECT/CT", "biodistribution", "studies", "with", "I-labeled", "NHS-IL12", "revealed", "significant", "in", "vivo", "enrichment", "of", "NHS-IL12", "inside", "the", "sarcoma", "microenvironment", "(", "Fig.", "2A", ")", "." ] } ]
PMC11352746
This analysis sheds light on trends and patterns that will enhance the use of live-cell imaging instruments in CNS drug discovery.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "analysis", "sheds", "light", "on", "trends", "and", "patterns", "that", "will", "enhance", "the", "use", "of", "live-cell", "imaging", "instruments", "in", "CNS", "drug", "discovery", "." ] } ]
PMC11638288
2The molecular mechanism and function of NKp46 in combating M. tuberculosis infection.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2The", "molecular", "mechanism", "and", "function", "of", "NKp46", "in", "combating", "M.", "tuberculosis", "infection", "." ] } ]
PMC6617630
The combination of both drugs reduced BCL-XL and MCL-1 levels more than either single agent alone in WT and THL; however, no changes were seen in BIM levels at the doses used in all the cell lines tested (Fig. 8d).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "of", "both", "drugs", "reduced", "BCL-XL", "and", "MCL-1", "levels", "more", "than", "either", "single", "agent", "alone", "in", "WT", "and", "THL", ";", "however", ",", "no", "changes", "were", "seen", "in", "BIM", "levels", "at", "the", "doses", "used", "in", "all", "the", "cell", "lines", "tested", "(", "Fig.", "8d", ")", "." ] } ]
PMC10873328
Cell survival after A2780/CDDP were transfected with siRNA, followed by the concentration gradient stimulation of cisplatin (0, 2.5, 5, 10, 20, 40, 80, 160, 320 and 640 μM).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "survival", "after", "A2780/CDDP", "were", "transfected", "with", "siRNA", ",", "followed", "by", "the", "concentration", "gradient", "stimulation", "of", "cisplatin", "(", "0", ",", "2.5", ",", "5", ",", "10", ",", "20", ",", "40", ",", "80", ",", "160", ",", "320", "and", "640", "μM", ")", "." ] } ]
PMC3734024
Equal concentrations(7.5×10 cells/mL) of stimulated B cells and freshly-isolated CD19 B cells were then cultured in 96-well flat-bottomed plates with either no further stimulation, or with PMA (50 ng/mL) and ionomycin (1 µg/mL).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equal", "concentrations(7.5", "×", "10", "cells/mL", ")", "of", "stimulated", "B", "cells", "and", "freshly-isolated", "CD19", "B", "cells", "were", "then", "cultured", "in", "96-well", "flat-bottomed", "plates", "with", "either", "no", "further", "stimulation", ",", "or", "with", "PMA", "(", "50", "ng/mL", ")", "and", "ionomycin", "(", "1", "µg/mL", ")", "." ] } ]
PMC9784246
Altogether 102 metabolites were tentatively identified in the different C. macrocarpa leaves total methanolic extract and its polar fractions utilizing the UPLC-ESI-MS/MS in the negative (Figures S1 and S2) and positive ionization modes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Altogether", "102", "metabolites", "were", "tentatively", "identified", "in", "the", "different", "C.", "macrocarpa", "leaves", "total", "methanolic", "extract", "and", "its", "polar", "fractions", "utilizing", "the", "UPLC-ESI-MS/MS", "in", "the", "negative", "(", "Figures", "S1", "and", "S2", ")", "and", "positive", "ionization", "modes", "." ] } ]
PMC11412721
Survival curves for the 30% patients with the highest MT2A mRNA levels and the 30% patients with the lowest MT2A mRNA levels according to sex (n = cohort sizes), for patients from dataset #GSE4475. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Survival", "curves", "for", "the", "30", "%", "patients", "with", "the", "highest", "MT2A", "mRNA", "levels", "and", "the", "30", "%", "patients", "with", "the", "lowest", "MT2A", "mRNA", "levels", "according", "to", "sex", "(", "n", "=", "cohort", "sizes", ")", ",", "for", "patients", "from", "dataset", "#", "GSE4475", ".", "(" ] } ]
PMC11748335
Cell cultures were maintained in a 37 °C incubator containing 5% CO2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "cultures", "were", "maintained", "in", "a", "37", "°", "C", "incubator", "containing", "5", "%", "CO2", "." ] } ]
PMC11087301
Cancer stem cells (CSCs) are known to be key players in the development of tumor heterogeneity and resistance to cancer therapy .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "stem", "cells", "(", "CSCs", ")", "are", "known", "to", "be", "key", "players", "in", "the", "development", "of", "tumor", "heterogeneity", "and", "resistance", "to", "cancer", "therapy", "." ] } ]
PMC10734950
Based on these assays, it was concluded that F8 induced cell death via the apoptotic pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "these", "assays", ",", "it", "was", "concluded", "that", "F8", "induced", "cell", "death", "via", "the", "apoptotic", "pathway", "." ] } ]
PMC11317131
PE has been used to insert att site landing pads for insertion of large DNA cargos by integrases (Figure 1A and Supplementary Figure S1a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PE", "has", "been", "used", "to", "insert", "att", "site", "landing", "pads", "for", "insertion", "of", "large", "DNA", "cargos", "by", "integrases", "(", "Figure", "1A", "and", "Supplementary", "Figure", "S1a", ")", "." ] } ]
PMC11564322
Therefore, we can assume that the low expression of c-MYC mRNA in HL-60 and the lack of changes in other cells promote differentiation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "can", "assume", "that", "the", "low", "expression", "of", "c-MYC", "mRNA", "in", "HL-60", "and", "the", "lack", "of", "changes", "in", "other", "cells", "promote", "differentiation", "." ] } ]
PMC10212663
Final cell counting was performed from 5 microscopic fields under random selection.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Final", "cell", "counting", "was", "performed", "from", "5", "microscopic", "fields", "under", "random", "selection", "." ] } ]
PMC11680049
A special role is assigned to phenolic compounds, mostly flavonoids, in the photoprotection of plant tissues; accumulating in the cells of the epidermis and mesophyll (Figure 2), they prevent the pathological effects of UV rays on proteins and lipids, as well as on the photosynthetic and genetic machinery.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "special", "role", "is", "assigned", "to", "phenolic", "compounds", ",", "mostly", "flavonoids", ",", "in", "the", "photoprotection", "of", "plant", "tissues", ";", "accumulating", "in", "the", "cells", "of", "the", "epidermis", "and", "mesophyll", "(", "Figure", "2", ")", ",", "they", "prevent", "the", "pathological", "effects", "of", "UV", "rays", "on", "proteins", "and", "lipids", ",", "as", "well", "as", "on", "the", "photosynthetic", "and", "genetic", "machinery", "." ] } ]
PMC10674574
According to the pharmaceutical requirements, the validation of the Caco-2 cell line is based on demonstrating an appropriate rank order relationship between the experimental permeability values of established model drugs and their absorption in human subjects .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "pharmaceutical", "requirements", ",", "the", "validation", "of", "the", "Caco-2", "cell", "line", "is", "based", "on", "demonstrating", "an", "appropriate", "rank", "order", "relationship", "between", "the", "experimental", "permeability", "values", "of", "established", "model", "drugs", "and", "their", "absorption", "in", "human", "subjects", "." ] } ]
PMC10135767
Treatment with 2-APB had no significant influence on the delay time, peak time, or peak intensity, suggesting that calcium signaling in RPMI 8226 cells was unaffected by blocking the calcium channel on the endoplasmic reticulum with 2-APB (Figure 5B–D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "2-APB", "had", "no", "significant", "influence", "on", "the", "delay", "time", ",", "peak", "time", ",", "or", "peak", "intensity", ",", "suggesting", "that", "calcium", "signaling", "in", "RPMI", "8226", "cells", "was", "unaffected", "by", "blocking", "the", "calcium", "channel", "on", "the", "endoplasmic", "reticulum", "with", "2-APB", "(", "Figure", "5B", "–", "D", ")", "." ] } ]
PMC9429973
Patients were on average 66 years old and mean CCI was 5.15.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", "on", "average", "66", "years", "old", "and", "mean", "CCI", "was", "5.15", "." ] } ]
PMC9841531
The respective amine was coupled to intermediate 16 to result in target compounds 17–32.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "respective", "amine", "was", "coupled", "to", "intermediate", "16", "to", "result", "in", "target", "compounds", "17–32", "." ] } ]
PMC11337594
The fixed cells were then washed with PBS and incubated with 0.2% Triton X-100 and 0.2% BSA in PBS for 10 min on ice for permeabilization.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fixed", "cells", "were", "then", "washed", "with", "PBS", "and", "incubated", "with", "0.2", "%", "Triton", "X-100", "and", "0.2", "%", "BSA", "in", "PBS", "for", "10", "min", "on", "ice", "for", "permeabilization", "." ] } ]
PMC11407042
•Ensure that all the bubbles have been eliminated completely.•Carefully transfer the supernatant to the LDH measurement plate and avoid transferring cells to the LDH measurement plate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "•Ensure", "that", "all", "the", "bubbles", "have", "been", "eliminated", "completely.•Carefully", "transfer", "the", "supernatant", "to", "the", "LDH", "measurement", "plate", "and", "avoid", "transferring", "cells", "to", "the", "LDH", "measurement", "plate", "." ] } ]
PMC11594641
The proliferation of RAB27A/B knockout cells was not suppressed (Figure 7A); however, we observed the inhibition of cell migration when analyzed by wound-healing assay, suggesting that Rab27B plays a more substantial role in this cell line motility (Figure 7B,C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "proliferation", "of", "RAB27A/B", "knockout", "cells", "was", "not", "suppressed", "(", "Figure", "7A", ")", ";", "however", ",", "we", "observed", "the", "inhibition", "of", "cell", "migration", "when", "analyzed", "by", "wound-healing", "assay", ",", "suggesting", "that", "Rab27B", "plays", "a", "more", "substantial", "role", "in", "this", "cell", "line", "motility", "(", "Figure", "7B", ",", "C", ")", "." ] } ]
PMC11676670
Additionally, OVAR79 cells demonstrated higher viability and proliferative activity after transfection compared to SKOV3 and OVCAR3 (Figure 1F).
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "OVAR79", "cells", "demonstrated", "higher", "viability", "and", "proliferative", "activity", "after", "transfection", "compared", "to", "SKOV3", "and", "OVCAR3", "(", "Figure", "1F", ")", "." ] } ]
PMC11698348
In brief, 10μg (micrograms) of protein were processed for western blot analysis, followed by membrane incubation with primary antibody overnight at 4°C.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "10μg", "(", "micrograms", ")", "of", "protein", "were", "processed", "for", "western", "blot", "analysis", ",", "followed", "by", "membrane", "incubation", "with", "primary", "antibody", "overnight", "at", "4", "°", "C", "." ] } ]
PMC11629143
Serine 2 is phosphorylated by CDK9 (cyclin‐dependent kinase 9), the kinase subunit of the P‐TEFb complex, which is recruited by BRD4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Serine", "2", "is", "phosphorylated", "by", "CDK9", "(", "cyclin‐dependent", "kinase", "9", ")", ",", "the", "kinase", "subunit", "of", "the", "P‐TEFb", "complex", ",", "which", "is", "recruited", "by", "BRD4", "." ] } ]
PMC11391695
Thus, this study provides a new direction for exploring the mechanisms in hepatocarcinogenesis and a novel therapeutic target for this deadly disease.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "this", "study", "provides", "a", "new", "direction", "for", "exploring", "the", "mechanisms", "in", "hepatocarcinogenesis", "and", "a", "novel", "therapeutic", "target", "for", "this", "deadly", "disease", "." ] } ]
PMC9429973
Results: 946 US patients (median age 72 years, male 75.1%) and 196 Japanese patients (median age 78 years, male 73.5%) met the eligibility criteria.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "946", "US", "patients", "(", "median", "age", "72", "years", ",", "male", "75.1", "%", ")", "and", "196", "Japanese", "patients", "(", "median", "age", "78", "years", ",", "male", "73.5", "%", ")", "met", "the", "eligibility", "criteria", "." ] } ]
PMC2777936
Canonical Wnt signalling is induced with human EC differentiation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Canonical", "Wnt", "signalling", "is", "induced", "with", "human", "EC", "differentiation", "." ] } ]
PMC11224020
The expression of each gene of interest was assessed in immature nonconfined cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "each", "gene", "of", "interest", "was", "assessed", "in", "immature", "nonconfined", "cells", "." ] } ]
PMC11754432
Collectively, this study demonstrates a role for ALOX15B in the resolution of psoriasis through modulation of EGFR and STAT1 via lipid peroxidation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "this", "study", "demonstrates", "a", "role", "for", "ALOX15B", "in", "the", "resolution", "of", "psoriasis", "through", "modulation", "of", "EGFR", "and", "STAT1", "via", "lipid", "peroxidation", "." ] } ]
PMC11787355
Same numbers of replicates were used from g. j Immunofluorescent staining of grafted i.c.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Same", "numbers", "of", "replicates", "were", "used", "from", "g.", "j", "Immunofluorescent", "staining", "of", "grafted", "i.c", "." ] } ]
PMC9429973
Megakaryocytes (MKs) are platelet producing cells that are controlled, in part, by this signaling pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Megakaryocytes", "(", "MKs", ")", "are", "platelet", "producing", "cells", "that", "are", "controlled", ",", "in", "part", ",", "by", "this", "signaling", "pathway", "." ] } ]
PMC6379402
For each of the breast, prostate, lung, and colorectal cancers, panels show the Kaplan–Meier survival curves of a newly prioritized gene from our computational analysis, the expression of which in patients allows for the most statistically significantly different survival curves (log-rank p values).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "of", "the", "breast", ",", "prostate", ",", "lung", ",", "and", "colorectal", "cancers", ",", "panels", "show", "the", "Kaplan", "–", "Meier", "survival", "curves", "of", "a", "newly", "prioritized", "gene", "from", "our", "computational", "analysis", ",", "the", "expression", "of", "which", "in", "patients", "allows", "for", "the", "most", "statistically", "significantly", "different", "survival", "curves", "(", "log-rank", "p", "values", ")", "." ] } ]
PMC11478724
Expression of BCL2, STAT3 and VDAC1 were significantly down-regulated in PMX-treated A549 vs Control A549 (d) Hsa-MiR-320a and genes expression profile In recent times, PMX has gained popularity as a chemotherapeutic drug for treating advanced NSCLC, and it has been approved for use in the first, second, and third lines of treatment for NSCLC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "BCL2", ",", "STAT3", "and", "VDAC1", "were", "significantly", "down-regulated", "in", "PMX-treated", "A549", "vs", "Control", "A549", "(", "d", ")", "Hsa-MiR-320a", "and", "genes", "expression", "profile", "In", "recent", "times", ",", "PMX", "has", "gained", "popularity", "as", "a", "chemotherapeutic", "drug", "for", "treating", "advanced", "NSCLC", ",", "and", "it", "has", "been", "approved", "for", "use", "in", "the", "first", ",", "second", ",", "and", "third", "lines", "of", "treatment", "for", "NSCLC", "." ] } ]
PMC9960565
Then, a bovine hemoglobin (Hg) standard curve was prepared (Figure S1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "a", "bovine", "hemoglobin", "(", "Hg", ")", "standard", "curve", "was", "prepared", "(", "Figure", "S1", ")", "." ] } ]
PMC11457557
MiR-21 involves in the process of DN, promotes urinary protein excretion, and aggravates renal function damage .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MiR-21", "involves", "in", "the", "process", "of", "DN", ",", "promotes", "urinary", "protein", "excretion", ",", "and", "aggravates", "renal", "function", "damage", "." ] } ]
PMC11144200
n = 3, ***P < 0.001, ****P < 0.0001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", ",", "*", "*", "*", "P", "<", "0.001", ",", "*", "*", "*", "*", "P", "<", "0.0001", "." ] } ]
PMC9454852
Statistical details (value of n, test used, p value, replicates, etc) are reported in the Figure Legends.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "details", "(", "value", "of", "n", ",", "test", "used", ",", "p", "value", ",", "replicates", ",", "etc", ")", "are", "reported", "in", "the", "Figure", "Legends", "." ] } ]
PMC11741906
We discovered nine dysregulated miRNAs; hsa-miR-133b, hsa-miR-203a-3p, hsa-miR-512-5p, hsa-miR-21-5p, hsa-miR-708-5p, hsa-miR-451a, hsa-miR-15b-5p, hsa-miR-200b-3p and hsa-miR-625-5p, whose expression was increased in cisplatin-resistant ovarian cancer cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "discovered", "nine", "dysregulated", "miRNAs", ";", "hsa-miR-133b", ",", "hsa-miR-203a-3p", ",", "hsa-miR-512", "-", "5p", ",", "hsa-miR-21", "-", "5p", ",", "hsa-miR-708", "-", "5p", ",", "hsa-miR-451a", ",", "hsa-miR-15b-5p", ",", "hsa-miR-200b-3p", "and", "hsa-miR-625", "-", "5p", ",", "whose", "expression", "was", "increased", "in", "cisplatin-resistant", "ovarian", "cancer", "cells", "." ] } ]
PMC11201989
Secondary antibodies used for IF staining include goat anti-mouse or donkey anti-rabbit conjugated with Alex Fluor 488 or 555, purchased from Invitrogen; and the secondary antibodies used for Western blot include donkey anti-rabbit IgG–horseradish peroxidase (sc-2313), donkey anti-goat IgG–horseradish peroxidase (sc-2020), and goat anti-mouse IgG–horseradish peroxidase (sc-2005), purchased from Santa Cruz Biotechnology Inc. (Dallas, TX, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "antibodies", "used", "for", "IF", "staining", "include", "goat", "anti-mouse", "or", "donkey", "anti-rabbit", "conjugated", "with", "Alex", "Fluor", "488", "or", "555", ",", "purchased", "from", "Invitrogen", ";", "and", "the", "secondary", "antibodies", "used", "for", "Western", "blot", "include", "donkey", "anti-rabbit", "IgG", "–", "horseradish", "peroxidase", "(", "sc-2313", ")", ",", "donkey", "anti-goat", "IgG", "–", "horseradish", "peroxidase", "(", "sc-2020", ")", ",", "and", "goat", "anti-mouse", "IgG", "–", "horseradish", "peroxidase", "(", "sc-2005", ")", ",", "purchased", "from", "Santa", "Cruz", "Biotechnology", "Inc.", "(", "Dallas", ",", "TX", ",", "USA", ")", "." ] } ]
PMC5574817
6Fig.
[ { "tags": [ "O", "O" ], "tokens": [ "6Fig", "." ] } ]
PMC11755519
Exosomes can be transported into the interstitial space and spread throughout the body.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exosomes", "can", "be", "transported", "into", "the", "interstitial", "space", "and", "spread", "throughout", "the", "body", "." ] } ]
PMC11633763
shRNA encoding USP22 or β‐catenin and overexpression plasmids encoding HK2 or USP22 were purchased from Genepharma in Shanghai, China.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "shRNA", "encoding", "USP22", "or", "β‐catenin", "and", "overexpression", "plasmids", "encoding", "HK2", "or", "USP22", "were", "purchased", "from", "Genepharma", "in", "Shanghai", ",", "China", "." ] } ]
PMC11127909
After treatment with PBS or cisplatin, 4% paraformaldehyde was used to fix the cell samples.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "treatment", "with", "PBS", "or", "cisplatin", ",", "4", "%", "paraformaldehyde", "was", "used", "to", "fix", "the", "cell", "samples", "." ] } ]
PMC11144200
Our findings demonstrated that the combination of activated CD8 T cells with doxorubicin/anti-CTLA-4 Nb co-loaded liposomes can effectively eradicate tumor cells both in vivo and in vitro.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "demonstrated", "that", "the", "combination", "of", "activated", "CD8", "T", "cells", "with", "doxorubicin/anti-CTLA-4", "Nb", "co-loaded", "liposomes", "can", "effectively", "eradicate", "tumor", "cells", "both", "in", "vivo", "and", "in", "vitro", "." ] } ]
PMC11705067
Conversely, low CDKN2A expression (HR 0.734; 95% CI 0.544-0.992, P = 0.044) predicted a favorable prognosis in patients suffering from ccRCC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", "low", "CDKN2A", "expression", "(", "HR", "0.734", ";", "95", "%", "CI", "0.544", "-", "0.992", ",", "P", "=", "0.044", ")", "predicted", "a", "favorable", "prognosis", "in", "patients", "suffering", "from", "ccRCC", "." ] } ]
PMC11122631
Among them, the major compound 3 displayed a significant cytotoxic effect with an IC50 value of 3.96 µM. We used the in silico tool CLC-Pred 2.0 to predict the possible cytotoxicity of test compounds for human tumor cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "them", ",", "the", "major", "compound", "3", "displayed", "a", "significant", "cytotoxic", "effect", "with", "an", "IC50", "value", "of", "3.96", "µM.", "We", "used", "the", "in", "silico", "tool", "CLC-Pred", "2.0", "to", "predict", "the", "possible", "cytotoxicity", "of", "test", "compounds", "for", "human", "tumor", "cell", "lines", "." ] } ]
PMC10165258
The statistical analysis of Figure 7B relies on a Wilcoxon-Mann-Whitney test.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statistical", "analysis", "of", "Figure", "7B", "relies", "on", "a", "Wilcoxon-Mann-Whitney", "test", "." ] } ]
PMC8494202
Normal human astrocytes and glioma cell lines LN229, T98, U251, and A172 were purchased from Procell Life Science & Technology Co, Ltd. (Hyderabad, India).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normal", "human", "astrocytes", "and", "glioma", "cell", "lines", "LN229", ",", "T98", ",", "U251", ",", "and", "A172", "were", "purchased", "from", "Procell", "Life", "Science", "&", "Technology", "Co", ",", "Ltd.", "(", "Hyderabad", ",", "India", ")", "." ] } ]
PMC9429973
This binding could be blocked by a P-selectin antibody, indicating that the interactions between MM cells and platelets are partially dependent on P-selectin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "binding", "could", "be", "blocked", "by", "a", "P-selectin", "antibody", ",", "indicating", "that", "the", "interactions", "between", "MM", "cells", "and", "platelets", "are", "partially", "dependent", "on", "P-selectin", "." ] } ]
PMC11627398
The “limma” R package (version 3.52.4) was applied to identify differentially expressed genes (DEGs) between septic shock samples and normal controls with the criteria of |log2FC| > 2 and p.adjust < 0.05 .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "“", "limma", "”", "R", "package", "(", "version", "3.52.4", ")", "was", "applied", "to", "identify", "differentially", "expressed", "genes", "(", "DEGs", ")", "between", "septic", "shock", "samples", "and", "normal", "controls", "with", "the", "criteria", "of", "|log2FC|", ">", "2", "and", "p.adjust", "<", "0.05", "." ] } ]
PMC8728081
At the same time, large particles had a ratio of (Hg:S) was 18.09:81.90 (Fig. 1b).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "same", "time", ",", "large", "particles", "had", "a", "ratio", "of", "(", "Hg", ":", "S", ")", "was", "18.09:81.90", "(", "Fig.", "1b", ")", "." ] } ]
PMC10454535
The NAC rescuing effects and downregulated oxidative stress defense proteins suggest oxidative stress as another mechanism targeted by PIN/BTZ in RPMI 8226 MM cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O" ], "tokens": [ "The", "NAC", "rescuing", "effects", "and", "downregulated", "oxidative", "stress", "defense", "proteins", "suggest", "oxidative", "stress", "as", "another", "mechanism", "targeted", "by", "PIN/BTZ", "in", "RPMI", "8226", "MM", "cells", "." ] } ]
PMC11683130
Whether SerpinB7 has a positive or negative effect on the pathogenesis of psoriasis depends on its expression level, which needs to be further verified.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whether", "SerpinB7", "has", "a", "positive", "or", "negative", "effect", "on", "the", "pathogenesis", "of", "psoriasis", "depends", "on", "its", "expression", "level", ",", "which", "needs", "to", "be", "further", "verified", "." ] } ]
PMC10713411
The calibration curve in the presence of 3-, 5-, and 7-year OS probability of the model in KIRC dataset. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "calibration", "curve", "in", "the", "presence", "of", "3-", ",", "5-", ",", "and", "7-year", "OS", "probability", "of", "the", "model", "in", "KIRC", "dataset", ".", "(" ] } ]
PMC10706275
The cell digestion solution was transferred into an Eppendorf tube, the supernatant was centrifuged, and then 200 µL of PBS was used for washing and another round of centrifugation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "digestion", "solution", "was", "transferred", "into", "an", "Eppendorf", "tube", ",", "the", "supernatant", "was", "centrifuged", ",", "and", "then", "200", "µL", "of", "PBS", "was", "used", "for", "washing", "and", "another", "round", "of", "centrifugation", "." ] } ]
PMC9429973
PK and PD of IBER were similar with concomitant administration of DARA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PK", "and", "PD", "of", "IBER", "were", "similar", "with", "concomitant", "administration", "of", "DARA", "." ] } ]
PMC5941560
Insertions longer than 50 bp that lie in coding exons (green); 6.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Insertions", "longer", "than", "50", "bp", "that", "lie", "in", "coding", "exons", "(", "green", ")", ";", "6", "." ] } ]
PMC9275501
In nearly 100 countries around the world, regardless of the level of development, cancer is one of the highly prevalent malignant diseases which is a major cause of morbidity and mortality.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "nearly", "100", "countries", "around", "the", "world", ",", "regardless", "of", "the", "level", "of", "development", ",", "cancer", "is", "one", "of", "the", "highly", "prevalent", "malignant", "diseases", "which", "is", "a", "major", "cause", "of", "morbidity", "and", "mortality", "." ] } ]
PMC11347429
The combined genotype (SIG geno combined) data from all batches, a total of 365 samples (including all duplicates), were then analyzed by PLINK ( (48), see Data set 19 for PLINK and subjects).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combined", "genotype", "(", "SIG", "geno", "combined", ")", "data", "from", "all", "batches", ",", "a", "total", "of", "365", "samples", "(", "including", "all", "duplicates", ")", ",", "were", "then", "analyzed", "by", "PLINK", "(", "(", "48", ")", ",", "see", "Data", "set", "19", "for", "PLINK", "and", "subjects", ")", "." ] } ]
PMC9000591
Next, samples (10 µL) with different dilution concentrations were added to each well.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "samples", "(", "10", "µL", ")", "with", "different", "dilution", "concentrations", "were", "added", "to", "each", "well", "." ] } ]
PMC6160470
After last wash, the accumulated Calcein within the cells was released into solution by treatment with 200 µL of 0.2% Triton X-100.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "last", "wash", ",", "the", "accumulated", "Calcein", "within", "the", "cells", "was", "released", "into", "solution", "by", "treatment", "with", "200", "µL", "of", "0.2", "%", "Triton", "X-100", "." ] } ]
PMC8708099
Our data confirmed the potential role of osthole in protection against inflammation in the gastrointestinal tract; therefore, osthole may be considered as an anti-inflammatory modulator in the treatment of inflammation after extensive in vitro and in vivo studies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "confirmed", "the", "potential", "role", "of", "osthole", "in", "protection", "against", "inflammation", "in", "the", "gastrointestinal", "tract", ";", "therefore", ",", "osthole", "may", "be", "considered", "as", "an", "anti-inflammatory", "modulator", "in", "the", "treatment", "of", "inflammation", "after", "extensive", "in", "vitro", "and", "in", "vivo", "studies", "." ] } ]
PMC11680982
PLKO.1 vectors with anti-hygromycin and anti-puromycin plasmids were constructed with appropriate primers.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLKO.1", "vectors", "with", "anti-hygromycin", "and", "anti-puromycin", "plasmids", "were", "constructed", "with", "appropriate", "primers", "." ] } ]
PMC11782508
The culture medium used in this study was formulated as follows (g/L): peptone 10.0; yeast extract 7.0; NaCl 2.5; KH2PO4 6.4; Na2HPO4 3.6; KNO3 0.5; and CuSO4.5H2O 0.005.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "culture", "medium", "used", "in", "this", "study", "was", "formulated", "as", "follows", "(", "g/L", "):", "peptone", "10.0", ";", "yeast", "extract", "7.0", ";", "NaCl", "2.5", ";", "KH2PO4", "6.4", ";", "Na2HPO4", "3.6", ";", "KNO3", "0.5", ";", "and", "CuSO4.5H2O", "0.005", "." ] } ]
PMC11718817
Motility of cells is a dynamic process characterized by the reorganization of the cytoskeleton.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Motility", "of", "cells", "is", "a", "dynamic", "process", "characterized", "by", "the", "reorganization", "of", "the", "cytoskeleton", "." ] } ]
PMC11737091
The RCC cell lines A498, and 786-O were purchased from IMMOCELL (Xiamen, China) and were subjected to validation via short tandem repeat (STR) analysis.
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RCC", "cell", "lines", "A498", ",", "and", "786-O", "were", "purchased", "from", "IMMOCELL", "(", "Xiamen", ",", "China", ")", "and", "were", "subjected", "to", "validation", "via", "short", "tandem", "repeat", "(", "STR", ")", "analysis", "." ] } ]
PMC10047551
Thus, increasing the methylation status of the PD-L1 gene corresponding to the region containing the CpG island at the promoter can directly decrease PD-L1 mRNA expression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "increasing", "the", "methylation", "status", "of", "the", "PD-L1", "gene", "corresponding", "to", "the", "region", "containing", "the", "CpG", "island", "at", "the", "promoter", "can", "directly", "decrease", "PD-L1", "mRNA", "expression", "." ] } ]
PMC11730320
Inspection of the read alignments (CRAM file) suggested that the coordinates are accurate and read depth is consistent with the expected segregation pattern in the nuclear family (i.e. heterozygous deletion in the parents, homozygous in the proband).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inspection", "of", "the", "read", "alignments", "(", "CRAM", "file", ")", "suggested", "that", "the", "coordinates", "are", "accurate", "and", "read", "depth", "is", "consistent", "with", "the", "expected", "segregation", "pattern", "in", "the", "nuclear", "family", "(", "i.e.", "heterozygous", "deletion", "in", "the", "parents", ",", "homozygous", "in", "the", "proband", ")", "." ] } ]
PMC9429973
Importantly, the highest synergism was found at low concentrations of both inhibitors, suggesting efficacy at moderate concentrations, which could potentially be achieved in vivo.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "the", "highest", "synergism", "was", "found", "at", "low", "concentrations", "of", "both", "inhibitors", ",", "suggesting", "efficacy", "at", "moderate", "concentrations", ",", "which", "could", "potentially", "be", "achieved", "in", "vivo", "." ] } ]
PMC9351137
Experimental groups were compared with control groups (mocks and scrambles) by Fisher’s exact test. *
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experimental", "groups", "were", "compared", "with", "control", "groups", "(", "mocks", "and", "scrambles", ")", "by", "Fisher", "’s", "exact", "test", ".", "*" ] } ]
PMC10587429
Antibodies for flow cytometry and immunofluorescent analyses. -
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antibodies", "for", "flow", "cytometry", "and", "immunofluorescent", "analyses", ".", "-" ] } ]
PMC9429973
Looking at environmental factors, in our cohort only residential background correlated with AML subtype, despite non-significance impact in prognosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Looking", "at", "environmental", "factors", ",", "in", "our", "cohort", "only", "residential", "background", "correlated", "with", "AML", "subtype", ",", "despite", "non-significance", "impact", "in", "prognosis", "." ] } ]
PMC11792090
Notably, a mutant form of the transmembrane domain of IL-7R was employed, allowing for the independent activation of IL-7 signaling in SAP UCAR-T cells, regardless of external IL-7 presence (36, 37).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "a", "mutant", "form", "of", "the", "transmembrane", "domain", "of", "IL-7R", "was", "employed", ",", "allowing", "for", "the", "independent", "activation", "of", "IL-7", "signaling", "in", "SAP", "UCAR-T", "cells", ",", "regardless", "of", "external", "IL-7", "presence", "(", "36", ",", "37", ")", "." ] } ]
PMC10813895
Contrasting evidence, however, indicates that progenitors from mammary ducts express higher levels of KRT15+ ELF5 compared to those from terminal duct lobular units (TDLU) .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Contrasting", "evidence", ",", "however", ",", "indicates", "that", "progenitors", "from", "mammary", "ducts", "express", "higher", "levels", "of", "KRT15", "+", "ELF5", "compared", "to", "those", "from", "terminal", "duct", "lobular", "units", "(", "TDLU", ")", "." ] } ]
PMC11575040
Our data revealed that CENPM expression exhibited a negative correlation with miR-1270 expression (r = − 0.182) (Table S3 and Fig. 8B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "data", "revealed", "that", "CENPM", "expression", "exhibited", "a", "negative", "correlation", "with", "miR-1270", "expression", "(", "r", "=", "−", "0.182", ")", "(", "Table", "S3", "and", "Fig.", "8B", ")", "." ] } ]
PMC11727145
Further studies are currently underway to assess primary keratinocyte and fibroblast combinations from multiple donors due to the high variability of keratinocyte cell culture from burn patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "are", "currently", "underway", "to", "assess", "primary", "keratinocyte", "and", "fibroblast", "combinations", "from", "multiple", "donors", "due", "to", "the", "high", "variability", "of", "keratinocyte", "cell", "culture", "from", "burn", "patients", "." ] } ]