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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Aims: To evaluate the impact of RUX vs BAT on CS use in pts with SR/D cGVHD in REACH3.
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PMC11637284
For TAC60, the p166-binding site corresponds to the short E175-L198 segment.
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PMC10988808
The 786–0 cells were washed with PBS to obtain a 1 × 10 cell /ml suspension.
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PMC9429973
In this study, we identified 3 patients with mutant MYD88 and wildtype CD79A/B (8.1%), among whom 2 harbored MYD88 L265P variants and 1 had MYD88 S219C mutation.
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PMC6222726
The cytotoxic activity of the new isolated compounds 26–28 against the cancer cell lines KB, PC-3, MCF-7, and HF-6 was evaluated, which showed that all of them displayed good activity against KB, PC-3, and HF-6, but were not active against the MCF-7 cell line.
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PMC11334037
Activation of molecular pathways follows KIT activation and leads to the occurrence of GISTs tumors by activation of cell proliferation and inhibition of apoptosis signals .
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PMC7887261
This del (rs746501298) is very rare in gnomAD (MAF 0.011%/0.0027% in non-cancer/NFE population controls), but presented in 1.02% of LCs and 0.02% of non-cancer controls (OR 4.48, 95%CI 1.73–11.55; P-value 0.0019).
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PMC10999934
We selected macrophages, monocytes, NK cells, T cells and B cells as reference normal cells.
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PMC10366908
The cetuximab treatment did not exhibit a benefit in patients with colorectal cancer harboring RAS mutations .
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PMC11481779
Our method is the next step towards obtaining a reliable and functional universal predictor of the spatial organisation of the chromatin within the nucleus, using purely DNA sequence - which would make connecting population studies with 3D genomics much easier and, foremost - cheaper.
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PMC7039683
G,H) qRT-PCR showing relative RNA expression of KRT18 (G) and KRT8 (H) in three homozygous knockout colonies (KO) and one isolated wild-type colony (Control) of GMSM-K cell lines. (
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PMC11805741
These findings underscore lutein’s role as a potent inhibitor of human breast cancer cell growth, facilitating cell death partly through the modulation of antioxidant defense response-related signaling markers (Kavalappa et al. 2021).
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PMC10547921
When the antibody binds to the tumor surface antigen, under the stimulation of near-infrared light, IR700 undergoes a photo-induced ligand release reaction, releasing the hydrophilic side chains, resulting in a significant increase in the hydrophobicity of the remaining part.
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PMC9429973
Our computational cell line models recreate how cells expressing distinct abundances of Bcl-2 proteins respond to BH3-mimetics through complex shifts in binding partners between pro-and anti-apoptotic Bcl-2 family proteins.
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PMC11627133
Our approach to protein labeling with bifunctional aptamers is modular, i.e., not only the protein‐binding aptamer but also the FLAP is exchangeable.
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PMC9429973
Whereas for OS resulted elevated LDH (HR 3.77 95%CI: 1.98-14.17, P=0.014) and ECOG-PS ≥2 (HR 4.59 95%CI: 1.46-14.39, P=0.004).
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PMC10006224
After 48 h, viruses were purified through centrifugation at 600 × g and filtered.
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PMC11742431
p < 0.01.
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PMC5035325
However, the expression of both targets in the same tumor sample was related with an even poorer prognosis in these patients .
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PMC10891340
Our results demonstrated a dose-dependent anti-DPV effect of CCCP, CCCP-treatment blocked the intercellular transmission of DPV after infection, and we also proved that CCCP could have an antiviral effect up to 48 hpi.
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PMC4369959
Thus, ginger prevents rat hepatocarcinogenesis .
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PMC7348793
The COS-7 cell line (CV1 in origin, SV40-transformed) was derived by Gluzman et al. in 1981 by transforming the African green monkey kidney epithelial cell line CV1 (derived ca.
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PMC11551844
Therefore, less activity was expected with AuNPs-JDE and AuNPs-JDH, as jaspamide present in JDE and JDH could not be converted into AuNPs.
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PMC7642379
The higher expression of such cell adhesion molecules in suspension cell lines compared to adherent progeny HEK293 cells may be explained by the loss of culture dish support to grow on in case of suspension cells.
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PMC11772585
In addition to generating ATP through the tricarboxylic acid (TCA) cycle, the intermediate metabolites of the TCA cycle are essential for tumor cell proliferation and the production of oncometabolites that support tumorigenesis rather than ATP production.
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PMC9429973
During the 12-month period preceding the index date, there were no statistically significant differences in the number of procedures, outpatient visits, and inpatient admissions between patients with and without PK deficiency (Table).
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PMC9429973
Antitumor activity will be evaluated based on overall response rate (ORR), progression-free survival (PFS), time to progression (TTP) and duration of response (DOR) based on disease-specific response criteria per investigator assessment.
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PMC11478724
This study used flow cytometry and Annexin V/FITC/PI (BD Biosciences, USA) labeling to investigate cellular apoptosis.
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PMC9318744
Our data are also in line with those reported by Cheng et al. (2021), showing that D614G substitution increased the virus titer.
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PMC11763111
At 0 and 48 h, the proportion and quantity of CAR-T and tumor cells were measured by flow cytometry, with tumor cells and NK cells acting as controls.
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PMC11180402
Futhermore, loss of miR-638 in vitro promotes cell invasion and mesenchymal-like transition by regulating SOX2 expression in colorectal carcinoma cells .
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PMC11549062
The recapitulated phenotype of less dynamic endocytosis suggests that the reduction of PDGFR impairs Rab5‐dependent endo‐lysosomal trafficking.
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PMC11528603
To identify the potential extracts against tested cancer cell line we evaluated the effect of the four fractions at the concentration of 40 μg/mL on cell growth.
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PMC11720107
However, PPARγ and its ligands are also involved in cell differentiation, autophagy, antioxidant enzyme production, and apoptotic cell death .
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PMC10253553
As noted, RICTOR is a required subunit of mTORC2 .
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PMC11365983
Consistently, RNA-sequencing demonstrates significantly reduced meningeal Pdgfra mRNA expression [27% mean FPKM decrease, q = 6.4 × 10], while in contrast Pdgfrb expression is unaltered. (
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PMC11711871
The upper blot was cut (stripped line).
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PMC11180402
Additionally, Tang et al. report that miR-129 promoter hypermethylation is responsible for the downregulation of miR-129 in breast cancer .
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PMC11535726
X. Tang, K.D. Hyde, Jayaward. &
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PMC11471176
Redirecting focus toward the involvement of ACE2 in resistant and more aggressive breast cancer cell lines, such as HER2 and basal-like, aligns seamlessly with the research findings above.
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PMC10747139
BOLD-100 was granted an orphan drug designation (ODD) in gastric and pancreatic cancers .
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PMC11621493
Lamp1, Calnexin, pan-Cadherin, and SDHA were used as marker-proteins for the endo-lysosomal compartment, ER, plasma membrane, and mitochondria, respectively.
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PMC10582049
We found ADH1B CAF markers such as A2M and MFAP4 among the top upregulated genes in ADH1B high group.
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PMC11637276
PP2A is composed of the “C” catalytic subunit, the “B” regulatory subunit, which confers target specificity , and the “A” scaffold subunit (S3A Fig).
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PMC11683240
Cell lysate was left untreated with biotin-NAD as further control (lysate).
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PMC9429973
Median prior duration of ruxolitinib use was 34.7 months for low PC compared with 14.9 months for higher PC; baseline symptoms were worse for patients with low PC than higher PC (median [range] MFSAF-TSS, 21.4 [0.6–47] vs 10 [0–43]).
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PMC11699042
To explore the differences in genome stability comparing COTF-driven strains to carcinoma strains in more detail, we employed WGS data and compared copy number alternations (CNAs) of A-673 and MCF-7 strains from different laboratories including our A-673_m0 and MCF-7_m0, those of the Cancer Cell Line Encyclopedia (CCLE), and an A-673 strain from the Ewing Sarcoma Cell Line Atlas (ESCLA).
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PMC11743975
Representative confocal images showing the dynamics of mCherry-CRY2clust and the Tom20-CIBN-GFP-labeled mitochondria before and after blue light illumination, and recovery in dark conditions as time indicated.
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PMC10887351
The ligand stimulation of β-adrenoceptors activates the Gs subunit where the active α subunit binds to the adenylyl cyclase (AC) that converts ATP into cyclic 3′-5′-adenosine monophosphate (cAMP) , which in turn activates the cAMP-dependent protein kinase A (PKA), with a phosphorylation of serine/threonine residues of β-AR kinase (β-ARK).
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PMC11705484
p < .05, **p < .01 and ***p < .001.
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PMC11543853
These contrasting results indicate that enteroviruses may employ not only various receptors to attach to cells and different endocytic pathways to gain entry into host cells, but also multiple mechanisms to breach endosome membranes.
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PMC8750422
Furthermore, we demonstrated that AKT-eNOS-NO signaling is a novel downstream pathway of GPR87 in lung adenocarcinoma.
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PMC11562028
Compared to the control group (Re-CDs, 0 μg mL), the mobility of the A498 cells was only ∼14.7% ± 0.6% at the Re-CDs concentration of 90 μg mL (Fig. 3H).
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PMC11621565
PSMα1, produced by Staphylococcus aureus, is involved in biofilm formation and it has the potential to catalyze α-synuclein aggregation.
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PMC11269933
Our previous study has showed that the average seawater temperature in the southern habitat (19.64°C) was significantly higher than that in the northern habitat (11.24°C; unpublished data), reflecting the distinct environmental temperature variations between the natural habitats of the two species.
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PMC11753949
In some cases, only a thin layer of actin separated ER cisterns, thus generating structures reminiscent of ER stacks of the spine apparatus.
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PMC11173119
For Sanger sequencing, we used BigDye Terminator V.3.1.
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PMC11180402
p < 0.05, #p < 0.05, ♣p < 0.05 vs. respective controls To further investigate the potential upstream regulators mediating ISO-mediated inhibition of SNHG1 transcription, bioinformatics analysis of the SNHG1 promoter was performed, and multiple binding sites for various transcription factors were identified, as shown in Fig. 3B.
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PMC11661024
This can illustrate the process of intrinsic apoptosis due to the elevated Bax gene expression as a member of the Bcl-2 gene family, which finally leads to the activation of caspase-8 and caspase-9.
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PMC9985266
To detect gene expression, RT‒qPCR was used.
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PMC6617630
Collectively, these findings demonstrate that treatment with the BETi sensitizes DHL and THL DLBCL cells to BCL-2 antagonist ABT-199.Fig.
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PMC9429973
The combination of the highly selective BCL-2 inhibitor venetoclax and the hypomethylating agent azacitidine was shown to be safe and effective in clinical trials (DiNardo et al. Blood.
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PMC11590005
The scale assesses the central notion of disguised prejudice and has two domains: ‘denial of prejudice’ and ‘affirmation of differences’.
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PMC10547921
SPEROVIE (WO2021046426A1, 2021.03.11) formed ADC drugs by conjugating thiophosphate or formate esters in CDN with PD-1 or CTLA-4 antibodies; Immunesensor (WO2021016204A1, 2021.01.28) elicited amino or mercapto from the ribose of the CDN at position 3′ and then forms an ADC drug by conjugating carbamate or disulfide bond to the antibody; MIT and Millennium (WO2021216572A1, 2021.10.28) innovatively conjured phospholipid molecules to phosphate esters of CDN.
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PMC7917457
For the NY-ESO-1 assay, CD8 T cells were presensitized with tumor antigen-containing peptides, with or without polylysine modification.
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PMC8409415
A2780cisR xenograft mice were intravenously administered with PBS, control‐ADC (3 mg/kg), or CD70‐ADC (3 mg/kg), and the tumors were excised 24 h later.
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PMC9429973
In vitro, MP0533 has demonstrated, in both allogeneic and autologous settings, single to double digit pM potency against AML cell lines and AML primary cells expressing any combination of at least 2 of the 3 targeted TAAs and low cytokine release.
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PMC11087055
Embryos were incubated with DAPI for 1 hr, washed for 30 min, then mounted between cover slips (VWR, 48366249), and slide glasses (Thermo Fisher Scientific, 12-544-7) with Aqua-PolyMount (Polysciences, Inc, #18606–20).
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PMC11351758
Laser iterations at 561 nm started at 20 s and ended at 300 s. We discovered that the Ca-treated cells for both the 143B and NARP cybrids showed faster depolarization of the membrane potential than did the Ca-free cells.
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PMC11301927
Patients provided a stool sample (OMNIgene Gut) at baseline.
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PMC9429973
Aims: We explored the sensitivity of a range of TCL lines to tolinapant, established the synergy coefficient and interrogated the role of necroptosis in the mechanism of synergy between tolinapant and drugs active against PTCL, the HMAs; azacytidine and decitabine Methods: A panel of 10 human TCL lines were tested in proliferation assays (CellTiterGlo) for sensitivity to tolinapant in the presence or absence of 10 ng/ml of TNFa.
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PMC7369657
After 4 weeks of treatment, all the tumor-bearing mice survived, and no significant body weight change was observed compared to the control groups (Figure 4(a)).
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PMC11655498
SM also binds to CBC, eIF4F, and PABP, thereby enhancing the translation initiation of mRNPs, which are involved in protein synthesis (Mure et al., 2018).
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PMC7917457
First, we assessed whether the polylysine addition to the NY-ESO-1 and MAGE-A3 antigens had any effects on immunogenicity, such as antigen processing and presentation by APCs.
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PMC11509224
Compound 172 showed activity against the A549, A2058, HepG2, and MiaPaca-2 cell lines, with IC50 values of 88.1, 71.4, 91.3, and 90.0 µM, respectively.
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PMC11718817
To investigate the effects of myeloid cell NLRP3 activation on CTL-induced tumor rejection, PancOVA spheroids were cultured with combinations of macrophages (either treated or not treated with LPS and nigericin) and OVA-reactive OT-I WT or Il18r CD8 effector CTLs (Figure 4A,B).
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PMC11802929
Logo plot in Fig. 2 was generated by Seq2Logo - 2.0 using default settings.
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PMC10547921
ABBV-3373, which AbbVie is developing, is also an ADC drug composed of α-TNF and GRM, that can precisely target the regulation of activated immune cells, modulate TNF-mediated inflammatory signaling pathways, significantly reduce glucocorticoid-related systemic side effects, and potentially treat rheumatoid arthritis (RA).
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PMC10900886
Lymphoid tissues can be the secondary replication site for EV-D68, from where the virus is released in the bloodstream.
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PMC9100622
The cells were harvested, washed with PBS, resuspended in 0.5% BSA-PBS, and fixed with 70% ethanol overnight at 4 °C.
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PMC7334607
For instance, Nichol et al. demonstrated that, after E. coli evolved resistance to cefotaxime (a β-lactam antibiotic) in 60 evolutionary replicates, there were highly heterogeneous changes in collateral sensitivity and resistance to alternative antibiotics (Nichol et al., 2019).
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PMC10669966
PDE3A protein expression was investigated with immunohistochemistry in 181 LPS samples, and PDE3A and SLFN12 mRNA expression with RT-qPCR were investigated in 63 LPS samples.
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PMC11635087
Color online) Measurement of photosynthetic quantum yield of isolated chloroplasts and incorporated chloroplasts in CHO-K1 cells at 0, 2 and 4 days after the co-cultivation via imaging PAM microscopy.
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PMC9611901
Unfortunately, because this pilot study did not involve complex chemical analyses, specific detection of chemicals released into the medium or determination of their total amounts, we cannot determine exactly which specific compounds were leached from a particular leather sample.
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PMC10040136
Conversely, the contents of all three primary isoforms of TGF-β remained unchanged when cultured independently (Fig. 4D, E).
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PMC9275501
In vitro and in vivo experiments showed that the nanoparticles had obvious cytotoxicity to HepG2 cells and could inhibit the growth of solid tumors in mice (Zeng et al., 2022).
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PMC11750712
The percentage of live cells was calculated relative to the number of live target cells after co-culture with non-transduced T cells.
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PMC9429973
COVID therapy was carried out according to the protocols adopted in the Russian Federation using antiviral drugs, biological therapy, corticosteroids, anticoagulants.
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PMC4695073
Therefore, for better clinical outcome with less toxicity, it is very necessary to identify molecular markers which could predict the resistance of platinum-based chemotherapy.
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PMC11437637
Table 3Analysis between patients with EC and uterine fibroidsAge (years)No.
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PMC11046454
The specific binding of AptEpCAM against EpCAM MDA-MB-231 cells (termed 231), but not EpCAM Jurkat T cells, was first verified with flow cytometry (Figure S11).
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PMC9841531
A standard PI staining procedure was used as described earlier to determine the effect of compounds 24 and 33 on cell cycle progression, followed by flow cytometry analysis (FACS Aria SORP and FACS Aria Fusion, BD Biosciences, Franklin Lakes, NJ).
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PMC10317042
The cell lysates were separated on 4%–12% Bis-Tris gels (Life Technologies) and transferred to polyvinylidene difluoride membranes (Nippon Genetics), which were incubated in Tris-buffered saline (TBS) containing 5% skim milk and Tween 20 (TBS-T) at room temperature.
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PMC11519077
In our study, microscopic observations showed that MSCs from patients had fibroblast-like, spindle-shaped morphology.
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PMC9621239
Moreover, in a clinical setting, mutations across the HBV X gene have been reported to be closely related to HCC, and some mutations were reported to even increase the risk of HCC development in patients with CHB, which further highlights the importance of HBV X mutation in the development of HCC.
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PMC11343332
Human breast cancer cells were injured, and a cell migration assay with and without treatment of pycnogenol (80 µg/ml) was performed at 24 h. Images were obtained using an inverted phase contrast microscope.
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PMC11787355
c Assessment of specific lysis of SCCs and FCCs upon short-term, 5 h, or long-term, 24 h, coculture with TCR-T cells, measured with cell counting by flow cytometry.
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PMC11285179
The human lung adenocarcinoma cell line (A549, SPC-A1, and H1975) and mouse Lewis lung cancer cell line (LLC) were purchased from the Shanghai Institute of Biochemistry and Cell Biology (SIBCB) and maintained in our lab.
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PMC9592219
It plays important roles in mitosis, including chromosome separation during DNA transcription and replication, chromatin compaction, and torsional stress relief .
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PMC10507284
According to the risk score calculation formula, we calculated the TROAP‐derived risk score of each STS patient and divided the STS patients into high and low‐risk groups.
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