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PMC11770746
The stability of the formulation was assessed upon storage at 4 °C for a week (6 days) in terms of micelles’ size and PDI and Pt(IV) drug loading.
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PMC11560255
According to this study, PMBE extracted from P. merkusii decreased the growth of proliferative cells, which was associated with the induction of apoptosis, as indicated by the increase in caspase activity.
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PMC11754432
ALOX15B has been associated with psoriasis, with increases in both the expression of ALOX15B and elevation of its AA, linoleic acid and docosahexaenoic acid (DHA) metabolites, 15-hydroxyeicosatetraenoic acid (HETE) 13-hydroxyoctadecadienoic acid and 17-hydroxydocosahexaenoic acid, respectively .
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PMC9429973
Aims: Our recent study aims to characterize KMT2A-rearranged acute myeloid leukemia in children in Russian Federation both in terms of partner genes involved and in accompanying mutations study.
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PMC11739504
acetyltransferase 2b (Kat2b), also known as the p300/CBP-associated factor (PCAF), has been recognized as a histone acetyltransferase (HAT) that promotes transcriptional activation.
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PMC11674891
After 24 h of incubation, cells that had migrated through the pores were stained using the Diff-Quick staining solution (Sysmex, Kobe, Japan) and observed under a microscope.
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PMC5330095
Cells were incubated at 37°C in a 5% CO2 incubator.
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PMC5308810
Both cell clones lost purity after 20 days of continuous culturing (three passages in the absence of doxorubicin), as shown by the CXCR4 clone’s dramatically reduction in the CXCR4-positive cell density (from 93% to 25%) and whereas the CXCR4 clone showed an increase of the CXCR4 population (from 1% to 5%). (
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PMC9429973
Aims: To explore the association between oxygen gradient ektacytometry-derived biomarkers, and blood viscosity with incidence of major (acute) SCD-related complications.
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PMC11786767
Given that we uncovered a significant negative correlation between intracellular Ki-67 protein levels and the inner/edge ratio of DHPE signals (Fig. 3E), we speculate that Ki-67 may prevent DHPE-labeled nuclear components (e.g., nuclear lipids) from moving into chromosomal interiors during prometaphase and metaphase, thereby promoting chromosome individualization.
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PMC8557138
These models are considered to be self-assembling or grow as cell clusters beginning from single-cell suspensions (Zhao et al. 2012).
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PMC7053076
5-Fluorouracil (5-FU) is an antimetabolite that interferes with DNA synthesis and has been widely used as a chemotherapeutic drug in various types of cancers.
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PMC8567602
A role for SMARCB1 and PBAF in TSS-specific binding may indicate their affinity for the H2A.Z-modified histones that reside at the TSS and +1 nucleosome positions (36).
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PMC9429973
Results: Seventy-one pts were enrolled.
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PMC9429973
AEs requiring dose interruption and/or dose change were reported in 24 (14.2%) patients.
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PMC4816271
Wild type CT26 were used as antigen negative controls (a,c) whereas CT26 –GD2 tumors treated with untransduced T cells (b) did not regress whilst CT26-GD2 tumors challenged with CAR T cells regressed.
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PMC11672142
To further make sense of the Fe(III) coordination within the Fe3(DefNEtTrp)2 complex, 1:1 Fe:triapine (pH 2) and 1:2 Fe:triapine (pH 8) species were prepared in situ following well-characterized speciation studies, by reacting 1 mol equivalent of Fe(III) with 2.5 equiv of triapine and carefully equilibrating the solutions to their respective pH values.
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PMC10114490
Red dots correspond to genes differentially expressed defined as FDR < 0.05 and fold change > 2 (0.6%).
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PMC7802142
Treatment with ReN-NV showed a substantial increase in C-myc and Cyclin D1 levels.
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PMC9429973
The most frequently reported mutation in patients with WHIM syndrome is c.1000C>T, which results in a C-terminal truncation of the receptor at position R334 (R334X).
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PMC11638288
This may be attributed to the ability of NKp46 NK cells to drive an immunosuppressive environment, thereby impeding adaptive T-cell immunity .
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PMC11768281
Understanding these pathways could pave the way for innovative therapeutic strategies to advance global malaria control and eradication efforts.
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PMC11777207
Data in (C) and (D) represent two combined experiments with BMDCs derived from two mice.
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PMC11711063
Cells were seeded onto 24‐well plates and pre‐treated for 48 h with control supernatant or conditioned medium containing ZG16B, labeled with Hoechst stain and washed with PBS.
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PMC11680982
Importantly, this intervention synergistically amplified the efficacy of CDK4/6 inhibitor combined with endocrine therapy in HR/HER2-low breast cancer by suppressing the HER2 pathway.
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PMC11335267
Functional diffusion-weighted magnetic resonance imaging reveals selective hypothalamic responses to fasting in the arcuate nucleus of Alx3-deficient mice.
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PMC10944868
The compounds were studied as possible CYP2D6, CYP3A4, CYP1A2, CYP2C19, and CYP2C9 enzyme inhibitors (Supplementary Table S1).
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PMC11412752
Salmonella Typhimurium strain was grown in Luria Bertani (LB) medium at 37°C with shaking overnight.
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PMC8414691
HeLa Kyoto EGFP-α-Tubulin/H2B-mCherry cell line (EMBL, Germany) were cultured and transfected according to the above section; 24 h after last transfection, cells were assayed for microtubules re-polymerization.
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PMC11568601
The cleaned reads were mapped to the reference genome using the HISAT2 software and quantification of gene expression levels was performed based on FPKM values.
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PMC10890307
Assessing for these kinetic parameters allowed for the determination of how much metabolite is consumed or produced per cell or 1 × 10 cells.
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PMC11549612
Additionally, survival curves based on genetic alterations revealed that the KIRC patient group with genetic alterations in BOLA1 and BOLA2 genes had significant good OS (p=0.046) compared to KIRC patients without mutations in these genes (Figure 2F).
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PMC10812665
Data extraction, peak identification and quality controls were performed by Metabolon using its own hardware and software.
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PMC11381192
We incorporated five cell stress patterns including heat, oxidative, hypoxic, genotoxic, and endoplasmic reticulum stresses, to develop a comprehensive cellular stress index (CSI).
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PMC11711345
A good advantage of the medicinal use of p-cymene and some of its derivatives is that they are widely available from natural sources [1-2, 5-6, 10-12].
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PMC10728200
A GIST-T1 cells were treated with IM (50 nM) for 24 h with or without MG132 (5 μM), and GPX4 ubiquitination was measured via CO-IP.
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PMC7504302
Additionally, ERβ colocalized with EGFR in Caveolin 1-enriched membrane fractions leading to delayed internalization of ERβ by interfering with EGFR phosphorylation.
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PMC11779993
On the other hand, elastin plays a key role in the elastic recoil of ECM and activates fibroblasts to deposit new matrix in acute and chronic wounds .
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PMC10994876
This contribution may be achieved by increasing the rate of protein synthesis through an enhancement in translational capacity.
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PMC9822769
A better understanding of such uptake could be achieved only by employing specific cell lines engineered for over-expression or under-expression of any possible gene of carrier proteins.
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PMC9118379
After applying FDR filtering, 320 variant PSMs passed an FDR <1%.
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PMC6267596
MYC is a dominant oncogenic transcription factor that regulates the expression of many cell cycle kinases including aurora kinases (AK) A and B. AKs are mitotic serine/threonine protein kinases that play key regulatory roles in the mitotic phase of the eukaryotic cell cycle.
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PMC7987994
Numbers above the columns stand for the concentration of measured Zn in µM. The dashed line stands for the normative limit of 70% metabolic activity of the control.
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PMC9429973
Patients’ data were analyzed from the Registry of Monoclonal Gammopathies of the Czech Myeloma Group (RMG).
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PMC11502327
Autophagy death of ovarian cancer cells was induced by up-regulating the expression of autophagy markers Beclin-1, LC3B, and Atg7, down-regulating the expression of P62, and inhibiting the expression of the Akt/mTOR/S6K pathway.
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PMC11291697
All the chemicals and reagents used in HPLC analysis were purchased from Merck Life Sciences (Darmstadt, Germany), except of methanol, acetonitrile, and tetrahydrofuran (Honeywell International, Seelze, Germany).
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PMC11401358
In detail, different concentrations of SF (3.125 mg/mL, 6.25 mg/mL, 12.5 mg/mL, 25 mg/mL, and 50 mg/mL) were incubated with 100 mM H2O2 at 37 °C for 1 h. After the reaction, the amount of residue was determined according to the kit instructions, and the H2O2 scavenging activity was calculated.
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PMC9964654
In addition, BCMs are able to increase drug solubility and stability and control delivery rates.
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PMC5415764
Primarily, the incorporation of iRGD peptide on LPN resulted in greater cancer cell targeting and penetration effects.
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PMC6684588
Intramuscular administration of ACE-083 caused localized, dose-dependent hypertrophy of the injected muscle in wild-type mice and mouse models of Charcot-Marie-Tooth disease (CMT) and Duchenne muscular dystrophy, with no evidence of systemic muscle effects or endocrine perturbation.
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PMC10965315
In addition, it should be noted that the impact shown by harmaline in the current study is in the high micromolar range which may undermine its potential as a therapeutic compound.
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PMC11381192
Characterisation of immune microenvironment based on the CSI signature. (
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PMC11765678
Cells were cultured in Phenol Red-free RPMI media, supplemented with 10% fetal bovine serum and antibiotics.
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PMC10547921
Derivative 34 containing non-hydrolysable N-substituents on tubuvaline (Tuv), with an IC50 < 0.28 nmol/L in HT-29 cells, also has the potential to act as ADC payloads.
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PMC11679326
High levels of phenotypic heterogeneity in brain tumors affect the biosynthetic pathway of glycosylation machinery, resulting in aberrant glycosylation patterns.
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PMC11531744
For the benefit of precision medicine and better prognosis in OC immunotherapy, it was critical to explore reliable immune-related biomarkers of prognosis and relevant molecular mechanisms.
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PMC10547921
The use of 690 nm wavelength near-infrared light to illuminate the tumor site induces Cetuximab sarotalocan to kill cancer cells and activate the immune response.
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PMC9429973
Median number of CAR-T cells detected by dPCR was greater than that quantified by MFC in each days of the follow-up (Figure 1D).
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PMC11297139
The top two enriched motifs are highlighted.
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PMC11474209
MtDNA destruction and mitophagy of faulty mitochondrial fragments can increase in response to elevated ROS or decreased DNA repair enzymes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MtDNA", "destruction", "and", "mitophagy", "of", "faulty", "mitochondrial", "fragments", "can", "increase", "in", "response", "to", "elevated", "ROS", "or", "decreased", "DNA", "repair", "enzymes", "." ] } ]
PMC9429973
Recent works demonstrated that chronic infection, ulcerative colitis (UC) and atherosclerosis, can drive the gene loss of function associated with CH.
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PMC9429973
For hematologic malignancies, but not restricted to, this represents a relevant obstacle in translating molecular findings into time critical treatment decisions.
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PMC9516401
Apart from insulin, other bioactive peptides such as glucagon, amylin, and amyloid-beta (Aβ) are targets of IDE (Tang, 2016 ▶).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apart", "from", "insulin", ",", "other", "bioactive", "peptides", "such", "as", "glucagon", ",", "amylin", ",", "and", "amyloid-beta", "(", "Aβ", ")", "are", "targets", "of", "IDE", "(", "Tang", ",", "2016", "▶", ")", "." ] } ]
PMC11686380
Immunofluorescence analyses were carried out as described.
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PMC10329074
P < 0.05, **P < 0.01, ***P < 0.001 The YBX3 expression was correlation with the immune infiltration. (
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PMC11718817
Therefore, an increase in velocity and a decrease in arrest coefficient due to nigericin treatment is concordant with the slightly reduced cytotoxic efficacy of T cells toward our spheroids.
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PMC9429973
MM may progress into so-called extramedullary disease (EMD) - EMD occurs when a subclone of malignant plasma cells migrates out of the bone marrow and infiltrates soft tissues.
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PMC9429973
Patients may suffer from severe infections and have a high risk of myeloid transformation.
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PMC11674146
While trying to link CLP36 and EMT, it has been demonstrated that CLP36 could prevent metastatic potential or EMT of colorectal cancer cells, as seen by the elevated CDH1 expression and the diminished VIM, Snail and ZEB levels (Chen et al., 2016; Kim et al., 2019).
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PMC9681981
The effect of close contact of enterocyte-like Caco-2 cells with C. perfringens type D (vaccine strain) on the production time of ε- and α-toxins was studied.
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PMC11789597
Lollipop Chart showing the top 10 import metabolites under POS and NEG model for distinguishing MM1S cells expressing shNC and shCAV.
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PMC11257988
Further research is required to better understand the pathways involved in KRAS mutation and to develop more targeted and effective drugs.
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PMC11627133
Therefore, we next compared RhoBAST‐PAINT and dSTORM within the same sample, using the previously described maSTORM setup.
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PMC11612626
Peptides were loaded on a trapping column and eluted over a 75-μm analytical column at 350 nL/minute; both columns were packed with Luna C18 resin (Phenomenex).
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PMC7823217
The format chosen and its alterations depend on the purpose of the model.
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PMC11727638
We previously reported an on-chip Cell Dome system that facilitates non-adherent cell culture and evaluation with ease .
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PMC11683240
A streptomycin resistant derivative of B. pertussis Tohama I was grown on Bordet-Gengou (BG) agar supplemented with 200 μg/ml streptomycin at 37 °C for two days and resuspended to an A600 nm of 1.0 in PBS.
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PMC11585994
Next, we investigated the anti-leukemia effects of G5-sgc8-siBCL11B nanoparticles on Molt4 and CEM cell lines.
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PMC11534035
We have demonstrated that SERPINE1/PAI1 functions as an oncogene, while an activated GPER1 acts as a tumor suppressor.
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PMC11761919
Data are expressed as mean ± SD, n = 3. **
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PMC11335267
Inter trial interval was 15 min.
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PMC9429973
Of 74 pts with complete reports, 69 pts remained in TFR (93%) and 5 pts lost TFR.
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PMC9777812
Bovine milk with optimal ingredients for newborn healthy growth and development is a high nutritional value food that is rich in protein and fat .
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PMC11792766
Data are shown as mean + standard error of the mean (SEM) (n = 9).
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PMC9429973
Median Kappa/Lambda ratios at the time of diagnosis were 13.84 and 13.1 at the time of relapse.
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PMC9429973
Safety and pharmacokinetic (PK)/pharmacodynamic (PD) evaluations will be completed on Days 4, 15, 22, 29, 36, 43, 50, 57, and 71.
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PMC11464609
The strong enrichment (median > 1000-fold) allowed a highly sensitive detection of viral pathogens even in low-biomass samples with high host background .
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PMC9429973
As of Feb 22, 2022, the median follow-up was 4 months (range 2-9.5).
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PMC9429973
Long-term efficacy, safety, PK and PD data are presented for the OLE.
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PMC9503669
This lack of activity may reflect the dose of lovastatin tested (40 mg once daily) which may not produce plasma levels sufficient to target the Nef protein based on the SPR data.
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PMC11794847
This suggests that the activation status of T cells plays a crucial role in determining their interaction and impact on tumor cell growth and mobility.
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PMC9429973
Targeted NGS of erythrocytosis-associated genes was applied in the other 6/13 patients.
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PMC11785489
To isolate (1) from (2), we analyzed nonproductive V(D)J recombination sequences that are not translated into surface TCR proteins.
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PMC11279598
These activated forms of STAT3 act, in turn, as oncogenic transcription factors to promote tumor progression.
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PMC9429973
Results: As of Jan 17 2022, 9 patients with r/r DLBCL were infused with Anbal-cel; 4pts at DL1, 3pts at DL2 and 2pts at DL2.
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PMC9429973
OS and EFS at 5 years were 76% and 70%, respectively.
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PMC11765879
It is worth mentioning that although the role of NF-κB as an anti-apoptotic and pro-survival agent in cancer has been previously shown, several in vitro and in vivo investigations reported an anti-tumorigenic and pro-apoptotic potential of this gene via different mechanisms in other types of cancer such as skin, liver, and ovarian .
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PMC9429973
Methods: We retrospectively evaluated patients with AML or MDS who underwent allo-HCT from an 8/8 HLA matched donor and received Flu/Mel (Mel dose of 100-140 mg/m.
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PMC11419566
Poria cocos, also known as Jade Ling and Songbai taro, is a dry fungus core for Wolfiporia cocos, which is parasitic on the roots of pine trees.
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PMC9429973
This MSM can be used to predict outcomes in AA patients receiving IST and can help in the decision whether and when to offer a patient an alloSCT.
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