OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9545474	Treatment of A2780 cells with complexes 6 and 8 (IC50 concentrations), or cisplatin (6.5 μM) led to shifts of the orange fluorescence to lower intensities indicating mitochondrial depolarisation (Figure 8 and Tables S8‐S11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "of", "A2780", "cells", "with", "complexes", "6", "and", "8", "(", "IC50", "concentrations", ")", ",", "or", "cisplatin", "(", "6.5", "μM", ")", "led", "to", "shifts", "of", "the", "orange", "fluorescence", "to", "lower", "intensities", "indicating", "mitochondrial", "depolarisation", "(", "Figure", "8", "and", "Tables", "S8‐S11", ")", "." ] } ]
PMC9429973	HMX3 only was unable to transform healthy human immature blood cells but appeared essential for survival of MLL-AF9 leukemia cell lines, potentially by positively regulating cell cycle progression and immune evasion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HMX3", "only", "was", "unable", "to", "transform", "healthy", "human", "immature", "blood", "cells", "but", "appeared", "essential", "for", "survival", "of", "MLL-AF9", "leukemia", "cell", "lines", ",", "potentially", "by", "positively", "regulating", "cell", "cycle", "progression", "and", "immune", "evasion", "." ] } ]
PMC11525028	The library was constructed using NEBNext Ultra RNA Library Prep Kit for Illumina (NEB) and sequencing was performed on the Illumina NovaSeq 6000 platform.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "library", "was", "constructed", "using", "NEBNext", "Ultra", "RNA", "Library", "Prep", "Kit", "for", "Illumina", "(", "NEB", ")", "and", "sequencing", "was", "performed", "on", "the", "Illumina", "NovaSeq", "6000", "platform", "." ] } ]
PMC11201989	In the Hedgehog (Hh) signaling pathway, for example, the dynamic movement of key components, such as Smoothened (Smo), and Gli-Kruppel family of zinc-finger (Gli) transcription factors into and out of the cilia rely significantly on the IFT machinery .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "Hedgehog", "(", "Hh", ")", "signaling", "pathway", ",", "for", "example", ",", "the", "dynamic", "movement", "of", "key", "components", ",", "such", "as", "Smoothened", "(", "Smo", ")", ",", "and", "Gli-Kruppel", "family", "of", "zinc-finger", "(", "Gli", ")", "transcription", "factors", "into", "and", "out", "of", "the", "cilia", "rely", "significantly", "on", "the", "IFT", "machinery", "." ] } ]
PMC4360730	The 22 new term requests for assays represented about 50% of all assays performed by the ENCODE Project at the beginning of our annotation efforts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "22", "new", "term", "requests", "for", "assays", "represented", "about", "50", "%", "of", "all", "assays", "performed", "by", "the", "ENCODE", "Project", "at", "the", "beginning", "of", "our", "annotation", "efforts", "." ] } ]
PMC11352311	Moreover, the interaction between GAPDH and Akt has been well-documented.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "interaction", "between", "GAPDH", "and", "Akt", "has", "been", "well-documented", "." ] } ]
PMC10253553	Thus, early detection and new therapies are critical for ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "early", "detection", "and", "new", "therapies", "are", "critical", "for", "ccRCC", "." ] } ]
PMC10523483	In addition, knockout of H1.2 increased tBHP-induced cell death, while overexpression of H1.2 led to increased survival (Fig. 3N and SI Appendix, Fig. S6G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "knockout", "of", "H1.2", "increased", "tBHP-induced", "cell", "death", ",", "while", "overexpression", "of", "H1.2", "led", "to", "increased", "survival", "(", "Fig.", "3N", "and", "SI", "Appendix", ",", "Fig.", "S6", "G", ")", "." ] } ]
PMC9429973	The Epidemiology of the therapeutic management of Multiple MYeloma in France (EMMY) study is a retrospective study capturing information on the therapeutic management of patients from 71 centers in France, and can serve as an external control arm for CARTITUDE-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Epidemiology", "of", "the", "therapeutic", "management", "of", "Multiple", "MYeloma", "in", "France", "(", "EMMY", ")", "study", "is", "a", "retrospective", "study", "capturing", "information", "on", "the", "therapeutic", "management", "of", "patients", "from", "71", "centers", "in", "France", ",", "and", "can", "serve", "as", "an", "external", "control", "arm", "for", "CARTITUDE-1", "." ] } ]
PMC3019555	P-values for Ago2-enriched transcripts (Fig. 5, A and B) were obtained using the Wilcoxon sum-rank test, and the Kruskal-Wallis test was used to calculate the p-value for HIF-MB/Ago2 colocalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-values", "for", "Ago2-enriched", "transcripts", "(", "Fig.", "5", ",", "A", "and", "B", ")", "were", "obtained", "using", "the", "Wilcoxon", "sum-rank", "test", ",", "and", "the", "Kruskal-Wallis", "test", "was", "used", "to", "calculate", "the", "p-value", "for", "HIF-MB/Ago2", "colocalization", "." ] } ]
PMC11718274	After that, plates of treated HSF and A-431 cells were washed with acetic acid (1%) and left to dry overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", ",", "plates", "of", "treated", "HSF", "and", "A-431", "cells", "were", "washed", "with", "acetic", "acid", "(", "1", "%", ")", "and", "left", "to", "dry", "overnight", "." ] } ]
PMC11612508	Furthermore, we have consistently received high-quality and satisfactory cell lines from this institution, utilized in several of our published articles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "have", "consistently", "received", "high-quality", "and", "satisfactory", "cell", "lines", "from", "this", "institution", ",", "utilized", "in", "several", "of", "our", "published", "articles", "." ] } ]
PMC9429973	Image: Summary/Conclusion: OHI index status strongly correlated with mortality in patients with lymphoma within our cohort, and death in OHI+ patients was largely due to causes other than progressive malignancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "OHI", "index", "status", "strongly", "correlated", "with", "mortality", "in", "patients", "with", "lymphoma", "within", "our", "cohort", ",", "and", "death", "in", "OHI+", "patients", "was", "largely", "due", "to", "causes", "other", "than", "progressive", "malignancy", "." ] } ]
PMC9792775	Western blot to detect protein expression of PD-L1 in A-204 and HT-1080 cells treated with LFU, PTX, and LFU + PTX for 48 h. (C) BCL2 expression versus immune infiltration of T cells, Th1 cells and macrophages. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "to", "detect", "protein", "expression", "of", "PD-L1", "in", "A-204", "and", "HT-1080", "cells", "treated", "with", "LFU", ",", "PTX", ",", "and", "LFU", "+", "PTX", "for", "48", "h.", "(", "C", ")", "BCL2", "expression", "versus", "immune", "infiltration", "of", "T", "cells", ",", "Th1", "cells", "and", "macrophages", ".", "(" ] } ]
PMC10571053	The ATPase assay was performed as described previously.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ATPase", "assay", "was", "performed", "as", "described", "previously", "." ] } ]
PMC11612626	HTS, high-throughput screens; tuba-A, tubastatin A. The 26S proteasome is composed of two subcomplexes: a 20S catalytic core particle capped at either or both ends by 19S regulatory particles that confer ATP and Ub-dependence (31).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HTS", ",", "high-throughput", "screens", ";", "tuba-A", ",", "tubastatin", "A.", "The", "26S", "proteasome", "is", "composed", "of", "two", "subcomplexes", ":", "a", "20S", "catalytic", "core", "particle", "capped", "at", "either", "or", "both", "ends", "by", "19S", "regulatory", "particles", "that", "confer", "ATP", "and", "Ub-dependence", "(", "31", ")", "." ] } ]
PMC11696576	Fig. 6Inhibition of cPLA2α causes oxidative stress-dependent cell death in acute leukemia cells.a The top 10 gene sets from the transcription factor target (C3), gene ontology (C5), and oncogenic signatures (C6) collections in the MSigDB that overlapped with the genes that were associated with resistance to cPLA2α inhibition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "6Inhibition", "of", "cPLA2α", "causes", "oxidative", "stress-dependent", "cell", "death", "in", "acute", "leukemia", "cells.a", "The", "top", "10", "gene", "sets", "from", "the", "transcription", "factor", "target", "(", "C3", ")", ",", "gene", "ontology", "(", "C5", ")", ",", "and", "oncogenic", "signatures", "(", "C6", ")", "collections", "in", "the", "MSigDB", "that", "overlapped", "with", "the", "genes", "that", "were", "associated", "with", "resistance", "to", "cPLA2α", "inhibition", "." ] } ]
PMC11670407	The viability of the cells was determined using the Cell Counting Kit-8 (HY-K0301, MCE).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "viability", "of", "the", "cells", "was", "determined", "using", "the", "Cell", "Counting", "Kit-8", "(", "HY-K0301", ",", "MCE", ")", "." ] } ]
PMC5415764	All drug release experiments were performed three times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "drug", "release", "experiments", "were", "performed", "three", "times", "." ] } ]
PMC7081114	Previous studies have reported that kinesins play critical roles in tumorigenesis and the progression of malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "studies", "have", "reported", "that", "kinesins", "play", "critical", "roles", "in", "tumorigenesis", "and", "the", "progression", "of", "malignancies", "." ] } ]
PMC11394227	The cells’ fluorescence intensity and average fluorescence intensity were analyzed by flow cytometry to determine the contents of the ER and Golgi apparatus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "’", "fluorescence", "intensity", "and", "average", "fluorescence", "intensity", "were", "analyzed", "by", "flow", "cytometry", "to", "determine", "the", "contents", "of", "the", "ER", "and", "Golgi", "apparatus", "." ] } ]
PMC11188874	Treatment of multiple myeloma cells with the negative control SGD-UBD253N MMCLs did not increase pan-MHC-I presentation (Supplementary Fig. S11B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "of", "multiple", "myeloma", "cells", "with", "the", "negative", "control", "SGD-UBD253N", "MMCLs", "did", "not", "increase", "pan-MHC-I", "presentation", "(", "Supplementary", "Fig.", "S11B", ")", "." ] } ]
PMC9429973	In apoptosis via crosslinking, the percentage of apoptotic cells in presence of daratumumab was higher in tinostamustine-pretreated MOLP-8 cells vsDMSO-pretreated cells (90.57%±7.35 vs 60.36%±2.86; p<0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "apoptosis", "via", "crosslinking", ",", "the", "percentage", "of", "apoptotic", "cells", "in", "presence", "of", "daratumumab", "was", "higher", "in", "tinostamustine-pretreated", "MOLP-8", "cells", "vsDMSO-pretreated", "cells", "(", "90.57%±7.35", "vs", "60.36%±2.86", ";", "p<0.001", ")", "." ] } ]
PMC8633974	A possible critique of our delivery choice is that patients will likely already be receiving combination antiretroviral drugs that inhibit lentivirus’ ability to transduce CRISPR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "possible", "critique", "of", "our", "delivery", "choice", "is", "that", "patients", "will", "likely", "already", "be", "receiving", "combination", "antiretroviral", "drugs", "that", "inhibit", "lentivirus", "’", "ability", "to", "transduce", "CRISPR", "." ] } ]
PMC8010066	They found that in polymicrobial infections, S. aureus increased the virulence factors of P. aeruginosa, which confirms our results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "found", "that", "in", "polymicrobial", "infections", ",", "S.", "aureus", "increased", "the", "virulence", "factors", "of", "P.", "aeruginosa", ",", "which", "confirms", "our", "results", "." ] } ]
PMC11574271	Activation of RON, either by ligand MSP stimulation or by aberrant expression, stimulates mitogen-activated protein kinase (MAPK), phosphatidylinositol 3 kinase (PI3K), and other signal pathways, resulting in increased cancerous cell proliferation, survival, migration, and matrix invasion .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "RON", ",", "either", "by", "ligand", "MSP", "stimulation", "or", "by", "aberrant", "expression", ",", "stimulates", "mitogen-activated", "protein", "kinase", "(", "MAPK", ")", ",", "phosphatidylinositol", "3", "kinase", "(", "PI3", "K", ")", ",", "and", "other", "signal", "pathways", ",", "resulting", "in", "increased", "cancerous", "cell", "proliferation", ",", "survival", ",", "migration", ",", "and", "matrix", "invasion", "." ] } ]
PMC11472569	The NBDs create a large pocket essential for ATP binding and hydrolysis, which is critical for ATPase activity and energy generation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NBDs", "create", "a", "large", "pocket", "essential", "for", "ATP", "binding", "and", "hydrolysis", ",", "which", "is", "critical", "for", "ATPase", "activity", "and", "energy", "generation", "." ] } ]
PMC8633974	Although, TatE2 and TatF target the same region as TatE, they showed comparatively lower efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", ",", "TatE2", "and", "TatF", "target", "the", "same", "region", "as", "TatE", ",", "they", "showed", "comparatively", "lower", "efficacy", "." ] } ]
PMC10033453	When CPEs were seen, media were collected from the flask and centrifuged to remove cell debris.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "CPEs", "were", "seen", ",", "media", "were", "collected", "from", "the", "flask", "and", "centrifuged", "to", "remove", "cell", "debris", "." ] } ]
PMC9429973	Thus, CH as a possible biological link, may be fed by the IBD inflammatory stimuli, and in turn, feed the IBD inflammation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "CH", "as", "a", "possible", "biological", "link", ",", "may", "be", "fed", "by", "the", "IBD", "inflammatory", "stimuli", ",", "and", "in", "turn", ",", "feed", "the", "IBD", "inflammation", "." ] } ]
PMC7759933	Correlating these results with the spheroid growth data, the spheroids with an initial density of 3000 cells/spheroid gradually increased in size and stayed uniformly spherical with limited degrees of necrosis up to day 12.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlating", "these", "results", "with", "the", "spheroid", "growth", "data", ",", "the", "spheroids", "with", "an", "initial", "density", "of", "3000", "cells/spheroid", "gradually", "increased", "in", "size", "and", "stayed", "uniformly", "spherical", "with", "limited", "degrees", "of", "necrosis", "up", "to", "day", "12", "." ] } ]
PMC10604092	Thus, we deduced that the decrease in muscle mass in the rats in our cancer cachexia model was a direct effect of tumor-secreted humoral factors or tumor–host interactions, whereas fat loss is an indirect effect of decreased dietary intake because of anorexia; we also deduced that the weight loss appeared as a result of both effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "we", "deduced", "that", "the", "decrease", "in", "muscle", "mass", "in", "the", "rats", "in", "our", "cancer", "cachexia", "model", "was", "a", "direct", "effect", "of", "tumor-secreted", "humoral", "factors", "or", "tumor", "–", "host", "interactions", ",", "whereas", "fat", "loss", "is", "an", "indirect", "effect", "of", "decreased", "dietary", "intake", "because", "of", "anorexia", ";", "we", "also", "deduced", "that", "the", "weight", "loss", "appeared", "as", "a", "result", "of", "both", "effects", "." ] } ]
PMC11279598	Activation of AMP-activated protein kinase (AMPK) has been found to inhibit tumor cell progression in several cancer types .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "AMP-activated", "protein", "kinase", "(", "AMPK", ")", "has", "been", "found", "to", "inhibit", "tumor", "cell", "progression", "in", "several", "cancer", "types", "." ] } ]
PMC11703992	Parallelly, in an LPS-induced shock model, DDIT4 knockdown mice exhibited reduced inflammation, which indicated the potential pro-inflammatory function of DDIT4 [13–15].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Parallelly", ",", "in", "an", "LPS-induced", "shock", "model", ",", "DDIT4", "knockdown", "mice", "exhibited", "reduced", "inflammation", ",", "which", "indicated", "the", "potential", "pro-inflammatory", "function", "of", "DDIT4", "[", "13–15", "]", "." ] } ]
PMC9429973	Methods: In this study, 120 patients diagnosed with MM between January 2018 and 2020 and 80 healthy individuals were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "In", "this", "study", ",", "120", "patients", "diagnosed", "with", "MM", "between", "January", "2018", "and", "2020", "and", "80", "healthy", "individuals", "were", "included", "." ] } ]
PMC9429973	Informed consent was obtained from all patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Informed", "consent", "was", "obtained", "from", "all", "patients", "." ] } ]
PMC9429973	Haematology, University College London Hospital; UCL Cancer Trials Centre; UCL Cancer Institute, University College London; RCTS, Kings College London; Dept.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Haematology", ",", "University", "College", "London", "Hospital", ";", "UCL", "Cancer", "Trials", "Centre", ";", "UCL", "Cancer", "Institute", ",", "University", "College", "London", ";", "RCTS", ",", "Kings", "College", "London", ";", "Dept", "." ] } ]
PMC9429973	Modulation of cell cycle phases distribution was assessed by flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Modulation", "of", "cell", "cycle", "phases", "distribution", "was", "assessed", "by", "flow", "cytometry", "." ] } ]
PMC9429973	Patients who were diagnosed with ET, pre-PMF or overt PMF according to the 2016 WHO revised Classification of MPN were included.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "who", "were", "diagnosed", "with", "ET", ",", "pre-PMF", "or", "overt", "PMF", "according", "to", "the", "2016", "WHO", "revised", "Classification", "of", "MPN", "were", "included", "." ] } ]
PMC8193046	The distances between the pharmacophore features are shown as light green lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "distances", "between", "the", "pharmacophore", "features", "are", "shown", "as", "light", "green", "lines", "." ] } ]
PMC10759659	Although not statistically significant, the same trend was observed in the MMR pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "not", "statistically", "significant", ",", "the", "same", "trend", "was", "observed", "in", "the", "MMR", "pathway", "." ] } ]
PMC10728200	We subsequently investigated the specific mechanism by which STUB1 regulates GPX4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "subsequently", "investigated", "the", "specific", "mechanism", "by", "which", "STUB1", "regulates", "GPX4", "." ] } ]
PMC11400680	mAP, mean average precision; MRCNN, mask region-based convolutional neural network.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mAP", ",", "mean", "average", "precision", ";", "MRCNN", ",", "mask", "region-based", "convolutional", "neural", "network", "." ] } ]
PMC9429973	Laboratory data analyses revealed that 25% of VTE-subjects had increased levels of both D-dimer and fibrinogen, and 11% had elevated levels of CRP, while no abnormalities were observed in the platelet and leucocyte counts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Laboratory", "data", "analyses", "revealed", "that", "25", "%", "of", "VTE-subjects", "had", "increased", "levels", "of", "both", "D-dimer", "and", "fibrinogen", ",", "and", "11", "%", "had", "elevated", "levels", "of", "CRP", ",", "while", "no", "abnormalities", "were", "observed", "in", "the", "platelet", "and", "leucocyte", "counts", "." ] } ]
PMC11592837	Cells were cultured in a humidified atmosphere (37 °C and 5% CO2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "in", "a", "humidified", "atmosphere", "(", "37", "°", "C", "and", "5", "%", "CO2", ")", "." ] } ]
PMC11723947	Then, WGCNA calculates the co-expression adjacency and transforms it into a Topological Overlap Matrix.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "WGCNA", "calculates", "the", "co-expression", "adjacency", "and", "transforms", "it", "into", "a", "Topological", "Overlap", "Matrix", "." ] } ]
PMC9784246	Taken together, C. macrocarpa polar fractions, in combination with chemotherapeutic agents, can have chemoprotective and synergistic effects in terms of reducing cancer chemotherapy-associated side effects and enhancing therapeutic efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken", "together", ",", "C.", "macrocarpa", "polar", "fractions", ",", "in", "combination", "with", "chemotherapeutic", "agents", ",", "can", "have", "chemoprotective", "and", "synergistic", "effects", "in", "terms", "of", "reducing", "cancer", "chemotherapy-associated", "side", "effects", "and", "enhancing", "therapeutic", "efficacy", "." ] } ]
PMC11434983	A431 cells were seeded in 6-well plates (1000 cells/well) for attachment.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A431", "cells", "were", "seeded", "in", "6-well", "plates", "(", "1000", "cells/well", ")", "for", "attachment", "." ] } ]
PMC11725127	GA can induce apoptosis in MM.1S and RPMI 8226 cell lines (n = 3). (	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GA", "can", "induce", "apoptosis", "in", "MM.1S", "and", "RPMI", "8226", "cell", "lines", "(", "n", "=", "3", ")", ".", "(" ] } ]
PMC5034105	Cell smears at 1, 3 and 5 d.p.i.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "smears", "at", "1", ",", "3", "and", "5", "d.p.i", "." ] } ]
PMC11300639	ns, not significant.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "ns", ",", "not", "significant", "." ] } ]
PMC9429973	Methods: Whole exome sequencing (WES) of DNA of patients with anemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Whole", "exome", "sequencing", "(", "WES", ")", "of", "DNA", "of", "patients", "with", "anemia", "." ] } ]
PMC11612626	RPMI-8226, ARH-77, and U266 were treated with compound A (1 μmol/L), TGFβ1 (10 ng/mL), or bortezomib (10 nmol/L) for 24 hours.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RPMI-8226", ",", "ARH-77", ",", "and", "U266", "were", "treated", "with", "compound", "A", "(", "1", "μmol/L", ")", ",", "TGFβ1", "(", "10", "ng/mL", ")", ",", "or", "bortezomib", "(", "10", "nmol/L", ")", "for", "24", "hours", "." ] } ]
PMC6450504	Data shown indicate triplicate mean ± SD from a blinded experiment. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "shown", "indicate", "triplicate", "mean", "±", "SD", "from", "a", "blinded", "experiment", ".", "*" ] } ]
PMC11247842	By default, the maximum distance to define an up-stream and downstream variant to a gene is 3 Kb.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "default", ",", "the", "maximum", "distance", "to", "define", "an", "up-stream", "and", "downstream", "variant", "to", "a", "gene", "is", "3", "Kb", "." ] } ]
PMC11225860	Tumors dissected and fixed in formalin and paraffin embedded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumors", "dissected", "and", "fixed", "in", "formalin", "and", "paraffin", "embedded", "." ] } ]
PMC11634027	ds, ds and ds wings were rounder than control wings (Fig. 1P).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ds", ",", "ds", "and", "ds", "wings", "were", "rounder", "than", "control", "wings", "(", "Fig.", "1P", ")", "." ] } ]
PMC9429973	Results: In accordance with a recent report, AEL cases were classified into 4 genomic groups (A-D), which are characterized by biallelic TP53 mutations and complex karyotype (Group-A), mutated NPM1 (Group-B) and STAG2 (Group-C), and other mutations in histone modifiers and transcription factors (Group-D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "In", "accordance", "with", "a", "recent", "report", ",", "AEL", "cases", "were", "classified", "into", "4", "genomic", "groups", "(", "A-D", ")", ",", "which", "are", "characterized", "by", "biallelic", "TP53", "mutations", "and", "complex", "karyotype", "(", "Group-A", ")", ",", "mutated", "NPM1", "(", "Group-B", ")", "and", "STAG2", "(", "Group-C", ")", ",", "and", "other", "mutations", "in", "histone", "modifiers", "and", "transcription", "factors", "(", "Group-D", ")", "." ] } ]
PMC9429973	In internal validation, the SVM model exhibited an optimal AUC of 0.879 ± 0.145 and an optimal F1 score of 0.748 ± 0.183.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "internal", "validation", ",", "the", "SVM", "model", "exhibited", "an", "optimal", "AUC", "of", "0.879", "±", "0.145", "and", "an", "optimal", "F1", "score", "of", "0.748", "±", "0.183", "." ] } ]
PMC11640115	These findings suggest that the imGPS is beneficial not only as a predictive marker for the prognosis of RMHNC but also as a helpful tool for forecasting OS and the therapeutic effect of pembrolizumab in RMHNC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "the", "imGPS", "is", "beneficial", "not", "only", "as", "a", "predictive", "marker", "for", "the", "prognosis", "of", "RMHNC", "but", "also", "as", "a", "helpful", "tool", "for", "forecasting", "OS", "and", "the", "therapeutic", "effect", "of", "pembrolizumab", "in", "RMHNC", "." ] } ]
PMC10758402	Therefore, the effect of DMF on oncolytic HSV-1 selective infectivity was evaluated to confirm that DMF does not enhance the replication of the virus in normal tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "effect", "of", "DMF", "on", "oncolytic", "HSV-1", "selective", "infectivity", "was", "evaluated", "to", "confirm", "that", "DMF", "does", "not", "enhance", "the", "replication", "of", "the", "virus", "in", "normal", "tissues", "." ] } ]
PMC11767817	Since we specifically observed an increase in p-Akt after treatment with 2a, we aimed to verify if inhibiting the Akt protein could enhance the cytotoxic activity of 2a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "we", "specifically", "observed", "an", "increase", "in", "p-Akt", "after", "treatment", "with", "2a", ",", "we", "aimed", "to", "verify", "if", "inhibiting", "the", "Akt", "protein", "could", "enhance", "the", "cytotoxic", "activity", "of", "2a", "." ] } ]
PMC11527437	Expression of the targeted antigen can be heterogeneous and low, which could lead to suboptimal tumor recognition in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "the", "targeted", "antigen", "can", "be", "heterogeneous", "and", "low", ",", "which", "could", "lead", "to", "suboptimal", "tumor", "recognition", "in", "vivo", "." ] } ]
PMC11391695	NPs, in particular, are extensively employed in the fabrication of gene drug delivery systems due to their exceptional chemical and physical characteristics .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NPs", ",", "in", "particular", ",", "are", "extensively", "employed", "in", "the", "fabrication", "of", "gene", "drug", "delivery", "systems", "due", "to", "their", "exceptional", "chemical", "and", "physical", "characteristics", "." ] } ]
PMC11545737	Another important point is the diverse consequences of pyroptosis pathways on calcium influx, like activation of calcium-dependent enzymes and mitochondria dysregulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "important", "point", "is", "the", "diverse", "consequences", "of", "pyroptosis", "pathways", "on", "calcium", "influx", ",", "like", "activation", "of", "calcium-dependent", "enzymes", "and", "mitochondria", "dysregulation", "." ] } ]
PMC10847511	These two scores were significantly higher in samples with BRCA1/2 mutation with LOH, BRCA1 methylation, and other HR-related gene mutations with LOH compared to those with HR-related gene mutations without LOH or without any HR-related gene mutations (P = 4.7 × 10, P = 0.037 respectively, Fig. 2b,c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "two", "scores", "were", "significantly", "higher", "in", "samples", "with", "BRCA1/2", "mutation", "with", "LOH", ",", "BRCA1", "methylation", ",", "and", "other", "HR-related", "gene", "mutations", "with", "LOH", "compared", "to", "those", "with", "HR-related", "gene", "mutations", "without", "LOH", "or", "without", "any", "HR-related", "gene", "mutations", "(", "P", "=", "4.7", "×", "10", ",", "P", "=", "0.037", "respectively", ",", "Fig.", "2b", ",", "c", ")", "." ] } ]
PMC10530622	Oxalate undergoes glomerular filtration and concentrations up to 0.005 µM might be physiologically achieved and increase up to 20-fold in persons with CKD .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oxalate", "undergoes", "glomerular", "filtration", "and", "concentrations", "up", "to", "0.005", "µM", "might", "be", "physiologically", "achieved", "and", "increase", "up", "to", "20-fold", "in", "persons", "with", "CKD", "." ] } ]
PMC11279397	To further investigate the biological function of Perilla frutescens, we utilized the Database for Annotation, Visualization and Integrated Discovery (DAVID, https://david.ncifcrf.gov/, accessed on 5 November 2023) to analyze the comprehensive set of target genes associated with Perilla frutescens, and conducted separate analyses to assess Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of these target genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "investigate", "the", "biological", "function", "of", "Perilla", "frutescens", ",", "we", "utilized", "the", "Database", "for", "Annotation", ",", "Visualization", "and", "Integrated", "Discovery", "(", "DAVID", ",", "https://david.ncifcrf.gov/", ",", "accessed", "on", "5", "November", "2023", ")", "to", "analyze", "the", "comprehensive", "set", "of", "target", "genes", "associated", "with", "Perilla", "frutescens", ",", "and", "conducted", "separate", "analyses", "to", "assess", "Gene", "Ontology", "(", "GO", ")", "enrichment", "and", "Kyoto", "Encyclopedia", "of", "Genes", "and", "Genomes", "(", "KEGG", ")", "pathway", "enrichment", "of", "these", "target", "genes", "." ] } ]
PMC9429973	Further characterization of CP-673451 treatment showed inhibition of PDGFR-β autophosphorylation both on western blot and flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "characterization", "of", "CP-673451", "treatment", "showed", "inhibition", "of", "PDGFR-β", "autophosphorylation", "both", "on", "western", "blot", "and", "flow", "cytometry", "." ] } ]
PMC11095939	Schematic for the PHx time course and data collection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "for", "the", "PHx", "time", "course", "and", "data", "collection", "." ] } ]
PMC10976516	Combining chemotherapy and radiotherapy can be considered a curative therapy for stage IIIB illness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combining", "chemotherapy", "and", "radiotherapy", "can", "be", "considered", "a", "curative", "therapy", "for", "stage", "IIIB", "illness", "." ] } ]
PMC11026382	Consequently, this pathway is strongly linked to cell growth and a frequent target of antibiotics and chemotherapeutics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "this", "pathway", "is", "strongly", "linked", "to", "cell", "growth", "and", "a", "frequent", "target", "of", "antibiotics", "and", "chemotherapeutics", "." ] } ]
PMC11363012	The anthocyanin peonidin-3-O-rutinoside (19), for which a standard is also available, was detected in the petals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anthocyanin", "peonidin-3-O-rutinoside", "(", "19", ")", ",", "for", "which", "a", "standard", "is", "also", "available", ",", "was", "detected", "in", "the", "petals", "." ] } ]
PMC11745823	Trametinib (GSK1120212) was purchased from Selleck.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Trametinib", "(", "GSK1120212", ")", "was", "purchased", "from", "Selleck", "." ] } ]
PMC10988555	To further evaluate if complexes 2 and 4 might induce apoptosis via an external stimulus, caspase 8 activity, which further triggers activation of the apoptotic process but in response to extrinsic stimuli, was measured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "evaluate", "if", "complexes", "2", "and", "4", "might", "induce", "apoptosis", "via", "an", "external", "stimulus", ",", "caspase", "8", "activity", ",", "which", "further", "triggers", "activation", "of", "the", "apoptotic", "process", "but", "in", "response", "to", "extrinsic", "stimuli", ",", "was", "measured", "." ] } ]
PMC11529598	Knockdown of miR-3154 in cell lines weakened ability of proliferation and colony formation, and caused cell cycle arrested and higher percentage of apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Knockdown", "of", "miR-3154", "in", "cell", "lines", "weakened", "ability", "of", "proliferation", "and", "colony", "formation", ",", "and", "caused", "cell", "cycle", "arrested", "and", "higher", "percentage", "of", "apoptosis", "." ] } ]
PMC8584319	Indeed, the combined treatment with AZD8055 and refametinib for different time points resulted in lower translational activity than AZD8055 treatment alone (Figure 4c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "the", "combined", "treatment", "with", "AZD8055", "and", "refametinib", "for", "different", "time", "points", "resulted", "in", "lower", "translational", "activity", "than", "AZD8055", "treatment", "alone", "(", "Figure", "4c", ")", "." ] } ]
PMC11721587	PLA was performed by using Duolink in situ detection reagents (MilliporeSigma) following the guidance of the manufacturer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLA", "was", "performed", "by", "using", "Duolink", "in", "situ", "detection", "reagents", "(", "MilliporeSigma", ")", "following", "the", "guidance", "of", "the", "manufacturer", "." ] } ]
PMC9429973	Summary/Conclusion: This is the first analysis of ponatinib treated patients in real-world in Argentina and demonstrates that ponatinib has a favorable efficacy and safety profile in patients with CML treated in standard clinical practice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "This", "is", "the", "first", "analysis", "of", "ponatinib", "treated", "patients", "in", "real-world", "in", "Argentina", "and", "demonstrates", "that", "ponatinib", "has", "a", "favorable", "efficacy", "and", "safety", "profile", "in", "patients", "with", "CML", "treated", "in", "standard", "clinical", "practice", "." ] } ]
PMC9429973	We aim to establish these models as tools that enable the prediction of the impact of targeted therapeutics on NFκB. Methods: Using a bespoke flow cytometry analysis pipeline, we have collected intracellular flow cytometry data for four NFκB subunits in two DLBCL cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "aim", "to", "establish", "these", "models", "as", "tools", "that", "enable", "the", "prediction", "of", "the", "impact", "of", "targeted", "therapeutics", "on", "NFκB.", "Methods", ":", "Using", "a", "bespoke", "flow", "cytometry", "analysis", "pipeline", ",", "we", "have", "collected", "intracellular", "flow", "cytometry", "data", "for", "four", "NFκB", "subunits", "in", "two", "DLBCL", "cell", "lines", "." ] } ]
PMC11046454	Statistical analysis of the percentage of CD3CD4 and CD3CD8 T cells in corresponding samples of E. (G) The serum concentration of TNF in tested mice sacrificed on day 42. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "of", "the", "percentage", "of", "CD3CD4", "and", "CD3CD8", "T", "cells", "in", "corresponding", "samples", "of", "E.", "(", "G", ")", "The", "serum", "concentration", "of", "TNF", "in", "tested", "mice", "sacrificed", "on", "day", "42", ".", "(" ] } ]
PMC10297204	The samples were initially fixed with a solution of 2.5% glutaraldehyde and 2% paraformaldehyde and then immersed in 1% osmium tetroxide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "were", "initially", "fixed", "with", "a", "solution", "of", "2.5", "%", "glutaraldehyde", "and", "2", "%", "paraformaldehyde", "and", "then", "immersed", "in", "1", "%", "osmium", "tetroxide", "." ] } ]
PMC11545737	Caspase-8 and RIP1 activation was also demonstrated in Y. enterocolitica-infected mouse bone marrow-derived dendritic cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caspase-8", "and", "RIP1", "activation", "was", "also", "demonstrated", "in", "Y.", "enterocolitica-infected", "mouse", "bone", "marrow-derived", "dendritic", "cells", "." ] } ]
PMC11617590	Gemcitabine has been applied in standard systemic chemotherapy since the 1990s; however, numerous ongoing studies are investigating ways to overcome the clinical limitations of monotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gemcitabine", "has", "been", "applied", "in", "standard", "systemic", "chemotherapy", "since", "the", "1990s", ";", "however", ",", "numerous", "ongoing", "studies", "are", "investigating", "ways", "to", "overcome", "the", "clinical", "limitations", "of", "monotherapy", "." ] } ]
PMC10878518	Therefore, CAR and hTERT expressions must be evaluated for the clinical application of OBP-301 to bone and soft-tissue sarcomas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "CAR", "and", "hTERT", "expressions", "must", "be", "evaluated", "for", "the", "clinical", "application", "of", "OBP-301", "to", "bone", "and", "soft-tissue", "sarcomas", "." ] } ]
PMC11737091	The proteins CHEK2, CDC7, CDC45, and ATR and the MCM family are all part of the PPI network of DBF4 and are involved in controlling the cell cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "proteins", "CHEK2", ",", "CDC7", ",", "CDC45", ",", "and", "ATR", "and", "the", "MCM", "family", "are", "all", "part", "of", "the", "PPI", "network", "of", "DBF4", "and", "are", "involved", "in", "controlling", "the", "cell", "cycle", "." ] } ]
PMC11574271	A test of the miR-659-3p expression in a panel of bladder cancer cell lines also confirmed that the expression levels of this particular miRNA were reversely correlated with the expression levels of RON (Fig. 6B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "test", "of", "the", "miR-659", "-", "3p", "expression", "in", "a", "panel", "of", "bladder", "cancer", "cell", "lines", "also", "confirmed", "that", "the", "expression", "levels", "of", "this", "particular", "miRNA", "were", "reversely", "correlated", "with", "the", "expression", "levels", "of", "RON", "(", "Fig.", "6B", ")", "." ] } ]
PMC3164356	The components underlying these phenotypes can be identified through the comparison of CHO gene content and gene expression with other organisms or cell lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "components", "underlying", "these", "phenotypes", "can", "be", "identified", "through", "the", "comparison", "of", "CHO", "gene", "content", "and", "gene", "expression", "with", "other", "organisms", "or", "cell", "lines", ".", "(" ] } ]
PMC9672323	The effect of drugs on the oxidative activity of T cells in PBMCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "drugs", "on", "the", "oxidative", "activity", "of", "T", "cells", "in", "PBMCs", "." ] } ]
PMC9429973	Age adjusted international Prognostic Index (aa-IPI) score was used to evaluate prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Age", "adjusted", "international", "Prognostic", "Index", "(", "aa-IPI", ")", "score", "was", "used", "to", "evaluate", "prognosis", "." ] } ]
PMC11742290	Although the majority of cancer studies suggest that LGR5 promotes tumor growth, several studies have reported the opposite results .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "majority", "of", "cancer", "studies", "suggest", "that", "LGR5", "promotes", "tumor", "growth", ",", "several", "studies", "have", "reported", "the", "opposite", "results", "." ] } ]
PMC11659921	We identified a total of 1524 angiogenesis‐related genes and 10,809 stemness‐related genes (score >1) from the GeneCards website.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "identified", "a", "total", "of", "1524", "angiogenesis‐related", "genes", "and", "10,809", "stemness‐related", "genes", "(", "score", ">", "1", ")", "from", "the", "GeneCards", "website", "." ] } ]
PMC11788920	CRISPR–dCas9-mediated transcription activation (CRISPRa) is simple, highly specific, programmable, and more versatile compared to traditional gene expression modulation methods that rely on modifying genes and promoters , as it primarily functions via recruitment of various effector proteins .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CRISPR", "–", "dCas9-mediated", "transcription", "activation", "(", "CRISPRa", ")", "is", "simple", ",", "highly", "specific", ",", "programmable", ",", "and", "more", "versatile", "compared", "to", "traditional", "gene", "expression", "modulation", "methods", "that", "rely", "on", "modifying", "genes", "and", "promoters", ",", "as", "it", "primarily", "functions", "via", "recruitment", "of", "various", "effector", "proteins", "." ] } ]
PMC11547972	Another mode of action may be relevant here.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "mode", "of", "action", "may", "be", "relevant", "here", "." ] } ]
PMC11578343	While further studies are needed to investigate this result, mz‐visco‐NPS is nonetheless capable of uncovering a remarkable level of viscoelastic heterogeneity across single cells that is typically masked by ensemble‐average measurements performed by other rheological platforms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "further", "studies", "are", "needed", "to", "investigate", "this", "result", ",", "mz‐visco‐NPS", "is", "nonetheless", "capable", "of", "uncovering", "a", "remarkable", "level", "of", "viscoelastic", "heterogeneity", "across", "single", "cells", "that", "is", "typically", "masked", "by", "ensemble‐average", "measurements", "performed", "by", "other", "rheological", "platforms", "." ] } ]
PMC11734514	One-way ANOVA followed by Tukey’s post hoc test was performed. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-way", "ANOVA", "followed", "by", "Tukey", "’s", "post", "hoc", "test", "was", "performed", ".", "*" ] } ]
PMC11583010	Frozen blocks of OCT were mounted on disks with OCT, and cryosection was performed at −20°C on a NX70 cryostat (Thermo Fisher Scientific).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Frozen", "blocks", "of", "OCT", "were", "mounted", "on", "disks", "with", "OCT", ",", "and", "cryosection", "was", "performed", "at", "−20", "°", "C", "on", "a", "NX70", "cryostat", "(", "Thermo", "Fisher", "Scientific", ")", "." ] } ]
PMC11770746	Hairs calibrated for forces between 0.008 and 2 g were applied 10 times each in ascending order of force at 5 s intervals to both hind paws.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hairs", "calibrated", "for", "forces", "between", "0.008", "and", "2", "g", "were", "applied", "10", "times", "each", "in", "ascending", "order", "of", "force", "at", "5", "s", "intervals", "to", "both", "hind", "paws", "." ] } ]
PMC7642379	Combined with the observed down-regulation of the entire cell adhesion gene set in progeny cell lines compared to HEK293 (Fig. 3a), results highlight changes in cytoskeleton and cell adhesion during continuous cultivation and cell line development of HEK293 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Combined", "with", "the", "observed", "down-regulation", "of", "the", "entire", "cell", "adhesion", "gene", "set", "in", "progeny", "cell", "lines", "compared", "to", "HEK293", "(", "Fig.", "3a", ")", ",", "results", "highlight", "changes", "in", "cytoskeleton", "and", "cell", "adhesion", "during", "continuous", "cultivation", "and", "cell", "line", "development", "of", "HEK293", "cells", "." ] } ]
PMC9429973	Moreover, our study may form the basis for future challenges aimed at developing combinatorial therapies targeting catalase regulatory pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "our", "study", "may", "form", "the", "basis", "for", "future", "challenges", "aimed", "at", "developing", "combinatorial", "therapies", "targeting", "catalase", "regulatory", "pathways", "." ] } ]

PMC9545474

Treatment of A2780 cells with complexes 6 and 8 (IC50 concentrations), or cisplatin (6.5 μM) led to shifts of the orange fluorescence to lower intensities indicating mitochondrial depolarisation (Figure 8 and Tables S8‐S11).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "of", "A2780", "cells", "with", "complexes", "6", "and", "8", "(", "IC50", "concentrations", ")", ",", "or", "cisplatin", "(", "6.5", "μM", ")", "led", "to", "shifts", "of", "the", "orange", "fluorescence", "to", "lower", "intensities", "indicating", "mitochondrial", "depolarisation", "(", "Figure", "8", "and", "Tables", "S8‐S11", ")", "." ] } ]

PMC9429973

HMX3 only was unable to transform healthy human immature blood cells but appeared essential for survival of MLL-AF9 leukemia cell lines, potentially by positively regulating cell cycle progression and immune evasion.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HMX3", "only", "was", "unable", "to", "transform", "healthy", "human", "immature", "blood", "cells", "but", "appeared", "essential", "for", "survival", "of", "MLL-AF9", "leukemia", "cell", "lines", ",", "potentially", "by", "positively", "regulating", "cell", "cycle", "progression", "and", "immune", "evasion", "." ] } ]

PMC11525028

The library was constructed using NEBNext Ultra RNA Library Prep Kit for Illumina (NEB) and sequencing was performed on the Illumina NovaSeq 6000 platform.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "library", "was", "constructed", "using", "NEBNext", "Ultra", "RNA", "Library", "Prep", "Kit", "for", "Illumina", "(", "NEB", ")", "and", "sequencing", "was", "performed", "on", "the", "Illumina", "NovaSeq", "6000", "platform", "." ] } ]

PMC11201989

In the Hedgehog (Hh) signaling pathway, for example, the dynamic movement of key components, such as Smoothened (Smo), and Gli-Kruppel family of zinc-finger (Gli) transcription factors into and out of the cilia rely significantly on the IFT machinery .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "Hedgehog", "(", "Hh", ")", "signaling", "pathway", ",", "for", "example", ",", "the", "dynamic", "movement", "of", "key", "components", ",", "such", "as", "Smoothened", "(", "Smo", ")", ",", "and", "Gli-Kruppel", "family", "of", "zinc-finger", "(", "Gli", ")", "transcription", "factors", "into", "and", "out", "of", "the", "cilia", "rely", "significantly", "on", "the", "IFT", "machinery", "." ] } ]

PMC4360730

The 22 new term requests for assays represented about 50% of all assays performed by the ENCODE Project at the beginning of our annotation efforts.

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PMC11352311

Moreover, the interaction between GAPDH and Akt has been well-documented.

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PMC10253553

Thus, early detection and new therapies are critical for ccRCC.

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PMC10523483

In addition, knockout of H1.2 increased tBHP-induced cell death, while overexpression of H1.2 led to increased survival (Fig. 3N and SI Appendix, Fig. S6G).

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PMC9429973

The Epidemiology of the therapeutic management of Multiple MYeloma in France (EMMY) study is a retrospective study capturing information on the therapeutic management of patients from 71 centers in France, and can serve as an external control arm for CARTITUDE-1.

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PMC3019555

P-values for Ago2-enriched transcripts (Fig. 5, A and B) were obtained using the Wilcoxon sum-rank test, and the Kruskal-Wallis test was used to calculate the p-value for HIF-MB/Ago2 colocalization.

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PMC11718274

After that, plates of treated HSF and A-431 cells were washed with acetic acid (1%) and left to dry overnight.

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PMC11612508

Furthermore, we have consistently received high-quality and satisfactory cell lines from this institution, utilized in several of our published articles.

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PMC9429973

Image: Summary/Conclusion: OHI index status strongly correlated with mortality in patients with lymphoma within our cohort, and death in OHI+ patients was largely due to causes other than progressive malignancy.

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PMC9792775

Western blot to detect protein expression of PD-L1 in A-204 and HT-1080 cells treated with LFU, PTX, and LFU + PTX for 48 h. (C) BCL2 expression versus immune infiltration of T cells, Th1 cells and macrophages. (

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PMC10571053

The ATPase assay was performed as described previously.

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PMC11612626

HTS, high-throughput screens; tuba-A, tubastatin A. The 26S proteasome is composed of two subcomplexes: a 20S catalytic core particle capped at either or both ends by 19S regulatory particles that confer ATP and Ub-dependence (31).

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PMC11696576

Fig. 6Inhibition of cPLA2α causes oxidative stress-dependent cell death in acute leukemia cells.a The top 10 gene sets from the transcription factor target (C3), gene ontology (C5), and oncogenic signatures (C6) collections in the MSigDB that overlapped with the genes that were associated with resistance to cPLA2α inhibition.

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PMC11670407

The viability of the cells was determined using the Cell Counting Kit-8 (HY-K0301, MCE).

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PMC5415764

All drug release experiments were performed three times.

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PMC7081114

Previous studies have reported that kinesins play critical roles in tumorigenesis and the progression of malignancies.

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PMC11394227

The cells’ fluorescence intensity and average fluorescence intensity were analyzed by flow cytometry to determine the contents of the ER and Golgi apparatus.

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PMC11188874

Treatment of multiple myeloma cells with the negative control SGD-UBD253N MMCLs did not increase pan-MHC-I presentation (Supplementary Fig. S11B).

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PMC9429973

In apoptosis via crosslinking, the percentage of apoptotic cells in presence of daratumumab was higher in tinostamustine-pretreated MOLP-8 cells vsDMSO-pretreated cells (90.57%±7.35 vs 60.36%±2.86; p<0.001).

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PMC8633974

A possible critique of our delivery choice is that patients will likely already be receiving combination antiretroviral drugs that inhibit lentivirus’ ability to transduce CRISPR.

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PMC8010066

They found that in polymicrobial infections, S. aureus increased the virulence factors of P. aeruginosa, which confirms our results.

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PMC11574271

Activation of RON, either by ligand MSP stimulation or by aberrant expression, stimulates mitogen-activated protein kinase (MAPK), phosphatidylinositol 3 kinase (PI3K), and other signal pathways, resulting in increased cancerous cell proliferation, survival, migration, and matrix invasion .

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PMC11472569

The NBDs create a large pocket essential for ATP binding and hydrolysis, which is critical for ATPase activity and energy generation.

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PMC8633974

Although, TatE2 and TatF target the same region as TatE, they showed comparatively lower efficacy.

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PMC10033453

When CPEs were seen, media were collected from the flask and centrifuged to remove cell debris.

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PMC9429973

Thus, CH as a possible biological link, may be fed by the IBD inflammatory stimuli, and in turn, feed the IBD inflammation.

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PMC7759933

Correlating these results with the spheroid growth data, the spheroids with an initial density of 3000 cells/spheroid gradually increased in size and stayed uniformly spherical with limited degrees of necrosis up to day 12.

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PMC10604092

Thus, we deduced that the decrease in muscle mass in the rats in our cancer cachexia model was a direct effect of tumor-secreted humoral factors or tumor–host interactions, whereas fat loss is an indirect effect of decreased dietary intake because of anorexia; we also deduced that the weight loss appeared as a result of both effects.

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PMC11279598

Activation of AMP-activated protein kinase (AMPK) has been found to inhibit tumor cell progression in several cancer types .

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PMC11703992

Parallelly, in an LPS-induced shock model, DDIT4 knockdown mice exhibited reduced inflammation, which indicated the potential pro-inflammatory function of DDIT4 [13–15].

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PMC9429973

Methods: In this study, 120 patients diagnosed with MM between January 2018 and 2020 and 80 healthy individuals were included.

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PMC9429973

Informed consent was obtained from all patients.

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PMC9429973

Haematology, University College London Hospital; UCL Cancer Trials Centre; UCL Cancer Institute, University College London; RCTS, Kings College London; Dept.

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PMC9429973

Modulation of cell cycle phases distribution was assessed by flow cytometry.

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PMC9429973

Patients who were diagnosed with ET, pre-PMF or overt PMF according to the 2016 WHO revised Classification of MPN were included.

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PMC8193046

The distances between the pharmacophore features are shown as light green lines.

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PMC10759659

Although not statistically significant, the same trend was observed in the MMR pathway.

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PMC10728200

We subsequently investigated the specific mechanism by which STUB1 regulates GPX4.

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PMC11400680

mAP, mean average precision; MRCNN, mask region-based convolutional neural network.

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PMC9429973

Laboratory data analyses revealed that 25% of VTE-subjects had increased levels of both D-dimer and fibrinogen, and 11% had elevated levels of CRP, while no abnormalities were observed in the platelet and leucocyte counts.

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PMC11592837

Cells were cultured in a humidified atmosphere (37 °C and 5% CO2).

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PMC11723947

Then, WGCNA calculates the co-expression adjacency and transforms it into a Topological Overlap Matrix.

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PMC9784246

Taken together, C. macrocarpa polar fractions, in combination with chemotherapeutic agents, can have chemoprotective and synergistic effects in terms of reducing cancer chemotherapy-associated side effects and enhancing therapeutic efficacy.

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PMC11434983

A431 cells were seeded in 6-well plates (1000 cells/well) for attachment.

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PMC11725127

GA can induce apoptosis in MM.1S and RPMI 8226 cell lines (n = 3). (

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PMC5034105

Cell smears at 1, 3 and 5 d.p.i.

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PMC11300639

ns, not significant.

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PMC9429973

Methods: Whole exome sequencing (WES) of DNA of patients with anemia.

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PMC11612626

RPMI-8226, ARH-77, and U266 were treated with compound A (1 μmol/L), TGFβ1 (10 ng/mL), or bortezomib (10 nmol/L) for 24 hours.

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PMC6450504

Data shown indicate triplicate mean ± SD from a blinded experiment. *

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PMC11247842

By default, the maximum distance to define an up-stream and downstream variant to a gene is 3 Kb.

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PMC11225860

Tumors dissected and fixed in formalin and paraffin embedded.

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PMC11634027

ds, ds and ds wings were rounder than control wings (Fig. 1P).

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PMC9429973

Results: In accordance with a recent report, AEL cases were classified into 4 genomic groups (A-D), which are characterized by biallelic TP53 mutations and complex karyotype (Group-A), mutated NPM1 (Group-B) and STAG2 (Group-C), and other mutations in histone modifiers and transcription factors (Group-D).

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PMC9429973

In internal validation, the SVM model exhibited an optimal AUC of 0.879 ± 0.145 and an optimal F1 score of 0.748 ± 0.183.

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PMC11640115

These findings suggest that the imGPS is beneficial not only as a predictive marker for the prognosis of RMHNC but also as a helpful tool for forecasting OS and the therapeutic effect of pembrolizumab in RMHNC.

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PMC10758402

Therefore, the effect of DMF on oncolytic HSV-1 selective infectivity was evaluated to confirm that DMF does not enhance the replication of the virus in normal tissues.

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PMC11767817

Since we specifically observed an increase in p-Akt after treatment with 2a, we aimed to verify if inhibiting the Akt protein could enhance the cytotoxic activity of 2a.

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PMC11527437

Expression of the targeted antigen can be heterogeneous and low, which could lead to suboptimal tumor recognition in vivo.

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PMC11391695

NPs, in particular, are extensively employed in the fabrication of gene drug delivery systems due to their exceptional chemical and physical characteristics .

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PMC11545737

Another important point is the diverse consequences of pyroptosis pathways on calcium influx, like activation of calcium-dependent enzymes and mitochondria dysregulation.

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PMC10847511

These two scores were significantly higher in samples with BRCA1/2 mutation with LOH, BRCA1 methylation, and other HR-related gene mutations with LOH compared to those with HR-related gene mutations without LOH or without any HR-related gene mutations (P = 4.7 × 10, P = 0.037 respectively, Fig. 2b,c).

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PMC10530622

Oxalate undergoes glomerular filtration and concentrations up to 0.005 µM might be physiologically achieved and increase up to 20-fold in persons with CKD .

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PMC11279397

To further investigate the biological function of Perilla frutescens, we utilized the Database for Annotation, Visualization and Integrated Discovery (DAVID, https://david.ncifcrf.gov/, accessed on 5 November 2023) to analyze the comprehensive set of target genes associated with Perilla frutescens, and conducted separate analyses to assess Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of these target genes.

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PMC9429973

Further characterization of CP-673451 treatment showed inhibition of PDGFR-β autophosphorylation both on western blot and flow cytometry.

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PMC11095939

Schematic for the PHx time course and data collection.

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PMC10976516

Combining chemotherapy and radiotherapy can be considered a curative therapy for stage IIIB illness.

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PMC11026382

Consequently, this pathway is strongly linked to cell growth and a frequent target of antibiotics and chemotherapeutics.

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PMC11363012

The anthocyanin peonidin-3-O-rutinoside (19), for which a standard is also available, was detected in the petals.

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PMC11745823

Trametinib (GSK1120212) was purchased from Selleck.

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PMC10988555

To further evaluate if complexes 2 and 4 might induce apoptosis via an external stimulus, caspase 8 activity, which further triggers activation of the apoptotic process but in response to extrinsic stimuli, was measured.

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PMC11529598

Knockdown of miR-3154 in cell lines weakened ability of proliferation and colony formation, and caused cell cycle arrested and higher percentage of apoptosis.

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PMC8584319

Indeed, the combined treatment with AZD8055 and refametinib for different time points resulted in lower translational activity than AZD8055 treatment alone (Figure 4c).

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PMC11721587

PLA was performed by using Duolink in situ detection reagents (MilliporeSigma) following the guidance of the manufacturer.

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PMC9429973

Summary/Conclusion: This is the first analysis of ponatinib treated patients in real-world in Argentina and demonstrates that ponatinib has a favorable efficacy and safety profile in patients with CML treated in standard clinical practice.

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PMC9429973

We aim to establish these models as tools that enable the prediction of the impact of targeted therapeutics on NFκB. Methods: Using a bespoke flow cytometry analysis pipeline, we have collected intracellular flow cytometry data for four NFκB subunits in two DLBCL cell lines.

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PMC11046454

Statistical analysis of the percentage of CD3CD4 and CD3CD8 T cells in corresponding samples of E. (G) The serum concentration of TNF in tested mice sacrificed on day 42. (

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PMC10297204

The samples were initially fixed with a solution of 2.5% glutaraldehyde and 2% paraformaldehyde and then immersed in 1% osmium tetroxide.

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PMC11545737

Caspase-8 and RIP1 activation was also demonstrated in Y. enterocolitica-infected mouse bone marrow-derived dendritic cells .

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PMC11617590

Gemcitabine has been applied in standard systemic chemotherapy since the 1990s; however, numerous ongoing studies are investigating ways to overcome the clinical limitations of monotherapy .

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PMC10878518

Therefore, CAR and hTERT expressions must be evaluated for the clinical application of OBP-301 to bone and soft-tissue sarcomas.

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PMC11737091

The proteins CHEK2, CDC7, CDC45, and ATR and the MCM family are all part of the PPI network of DBF4 and are involved in controlling the cell cycle.

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PMC11574271

A test of the miR-659-3p expression in a panel of bladder cancer cell lines also confirmed that the expression levels of this particular miRNA were reversely correlated with the expression levels of RON (Fig. 6B).

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PMC3164356

The components underlying these phenotypes can be identified through the comparison of CHO gene content and gene expression with other organisms or cell lines. (

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PMC9672323

The effect of drugs on the oxidative activity of T cells in PBMCs.

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PMC9429973

Age adjusted international Prognostic Index (aa-IPI) score was used to evaluate prognosis.

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PMC11742290

Although the majority of cancer studies suggest that LGR5 promotes tumor growth, several studies have reported the opposite results .

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PMC11659921

We identified a total of 1524 angiogenesis‐related genes and 10,809 stemness‐related genes (score >1) from the GeneCards website.

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PMC11788920

CRISPR–dCas9-mediated transcription activation (CRISPRa) is simple, highly specific, programmable, and more versatile compared to traditional gene expression modulation methods that rely on modifying genes and promoters , as it primarily functions via recruitment of various effector proteins .

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PMC11547972

Another mode of action may be relevant here.

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PMC11578343

While further studies are needed to investigate this result, mz‐visco‐NPS is nonetheless capable of uncovering a remarkable level of viscoelastic heterogeneity across single cells that is typically masked by ensemble‐average measurements performed by other rheological platforms.

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PMC11734514

One-way ANOVA followed by Tukey’s post hoc test was performed. *

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PMC11583010

Frozen blocks of OCT were mounted on disks with OCT, and cryosection was performed at −20°C on a NX70 cryostat (Thermo Fisher Scientific).

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PMC11770746

Hairs calibrated for forces between 0.008 and 2 g were applied 10 times each in ascending order of force at 5 s intervals to both hind paws.

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PMC7642379

Combined with the observed down-regulation of the entire cell adhesion gene set in progeny cell lines compared to HEK293 (Fig. 3a), results highlight changes in cytoskeleton and cell adhesion during continuous cultivation and cell line development of HEK293 cells.

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PMC9429973

Moreover, our study may form the basis for future challenges aimed at developing combinatorial therapies targeting catalase regulatory pathways.

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