Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC4685407
The CRISPR vector was constructed 5 bases from the Dnmt3a stop codon as the second target (Target 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CRISPR", "vector", "was", "constructed", "5", "bases", "from", "the", "Dnmt3a", "stop", "codon", "as", "the", "second", "target", "(", "Target", "2", ")", "." ] } ]
PMC3164356
The unmapped reads were used in a seed-and-extend strategy by TopHat to identify reads spanning across the splice junction.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "unmapped", "reads", "were", "used", "in", "a", "seed-and-extend", "strategy", "by", "TopHat", "to", "identify", "reads", "spanning", "across", "the", "splice", "junction", "." ] } ]
PMC11704135
The plates were further incubated at 37 °C with 5% CO2 for 4 h. Subsequently, 85 µl of media was removed from the wells, and 50 µl of DMSO was added and mixed thoroughly.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plates", "were", "further", "incubated", "at", "37", "°", "C", "with", "5", "%", "CO2", "for", "4", "h.", "Subsequently", ",", "85", "µl", "of", "media", "was", "removed", "from", "the", "wells", ",", "and", "50", "µl", "of", "DMSO", "was", "added", "and", "mixed", "thoroughly", "." ] } ]
PMC11387401
This could partially be explained by the potential masking of the RNA binding place of the protein by the alternative pulldown method.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "could", "partially", "be", "explained", "by", "the", "potential", "masking", "of", "the", "RNA", "binding", "place", "of", "the", "protein", "by", "the", "alternative", "pulldown", "method", "." ] } ]
PMC6222726
Images of the species reported in this paper can be found on the Enciclovida web site .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "of", "the", "species", "reported", "in", "this", "paper", "can", "be", "found", "on", "the", "Enciclovida", "web", "site", "." ] } ]
PMC11674834
CHO cell lysates containing 31–1000 µM 3,4-DMA (catalog: 126373, CAS number: 95-64-7 from Sigma Aldrich, St. Louis, MO, USA) and 300 µM acetyl coenzyme A (Sigma Aldrich, St. Louis, MO, USA) were incubated at 37 °C for 60 min.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHO", "cell", "lysates", "containing", "31–1000", "µM", "3,4-DMA", "(", "catalog", ":", "126373", ",", "CAS", "number", ":", "95", "-", "64", "-", "7", "from", "Sigma", "Aldrich", ",", "St.", "Louis", ",", "MO", ",", "USA", ")", "and", "300", "µM", "acetyl", "coenzyme", "A", "(", "Sigma", "Aldrich", ",", "St.", "Louis", ",", "MO", ",", "USA", ")", "were", "incubated", "at", "37", "°", "C", "for", "60", "min", "." ] } ]
PMC11682525
However, hypoxic preconditioning may attenuate inflammatory signaling pathways, dampening inflammation-induced cell death and promoting stem cell survival under oxidative stress conditions ( 44 ).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "hypoxic", "preconditioning", "may", "attenuate", "inflammatory", "signaling", "pathways", ",", "dampening", "inflammation-induced", "cell", "death", "and", "promoting", "stem", "cell", "survival", "under", "oxidative", "stress", "conditions", "(", "44", ")", "." ] } ]
PMC11201989
In this study, we identified PD-L1 at the centrosome and the spindle poles during mitosis, and its depletion resulted in centrosome amplification and cytokinesis defects.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "identified", "PD-L1", "at", "the", "centrosome", "and", "the", "spindle", "poles", "during", "mitosis", ",", "and", "its", "depletion", "resulted", "in", "centrosome", "amplification", "and", "cytokinesis", "defects", "." ] } ]
PMC11723947
We also failed to detect significant differences between peripheral CD4 and CD8 T cells from the two genotypes (Figure.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "failed", "to", "detect", "significant", "differences", "between", "peripheral", "CD4", "and", "CD8", "T", "cells", "from", "the", "two", "genotypes", "(", "Figure", "." ] } ]
PMC9596868
IC50 for MST-312 in OSEs was 8 µM and for quercetin it was 17.5 µM (Fig. 1D and H).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IC50", "for", "MST-312", "in", "OSEs", "was", "8", "µM", "and", "for", "quercetin", "it", "was", "17.5", "µM", "(", "Fig.", "1D", "and", "H", ")", "." ] } ]
PMC11531735
The cell lines were subjected to treatment with both Herceptin and ER121, administered at varying doses over a 72-hour period, followed by the quantification of cell viability using the MTT assay.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "lines", "were", "subjected", "to", "treatment", "with", "both", "Herceptin", "and", "ER121", ",", "administered", "at", "varying", "doses", "over", "a", "72-hour", "period", ",", "followed", "by", "the", "quantification", "of", "cell", "viability", "using", "the", "MTT", "assay", "." ] } ]
PMC4485786
On day 7, the cytokines were removed and the cells were trypsinized, counted, and reseeded at 2 × 10 cells/9.6 cm.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "day", "7", ",", "the", "cytokines", "were", "removed", "and", "the", "cells", "were", "trypsinized", ",", "counted", ",", "and", "reseeded", "at", "2", "×", "10", "cells/9.6", "cm", "." ] } ]
PMC8345486
8-(5-Azido-3-oxa-pentoxy)-3-metalla bis(1,2-dicarba-closo-undecaborates](-1) containing Co and Fe (9 and 10) and 10-(5-azido-3-oxa-pentoxy)-7,8- dicarba-nido-undecaborate(-1) (12) were obtained via dioxane ring opening in 5, 6 or 8 correspondingly with sodium azide in anhydrous dimethyl sulfoxide as described (Scheme 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "8-(5-Azido-3-oxa-pentoxy)-3-metalla", "bis(1,2-dicarba-closo-undecaborates](-1", ")", "containing", "Co", "and", "Fe", "(", "9", "and", "10", ")", "and", "10-(5-azido-3-oxa-pentoxy)-7,8-", "dicarba-nido-undecaborate(-1", ")", "(", "12", ")", "were", "obtained", "via", "dioxane", "ring", "opening", "in", "5", ",", "6", "or", "8", "correspondingly", "with", "sodium", "azide", "in", "anhydrous", "dimethyl", "sulfoxide", "as", "described", "(", "Scheme", "2", ")", "." ] } ]
PMC11768927
While some studies, such as Kottke et al. , have shown that NK cells may facilitate VSV localization within solid tumors, others report that NK cells can actually inhibit the efficacy of VSV-based cancer therapies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "some", "studies", ",", "such", "as", "Kottke", "et", "al.", ",", "have", "shown", "that", "NK", "cells", "may", "facilitate", "VSV", "localization", "within", "solid", "tumors", ",", "others", "report", "that", "NK", "cells", "can", "actually", "inhibit", "the", "efficacy", "of", "VSV-based", "cancer", "therapies", "." ] } ]
PMC9429973
We then focus on the assessment of iron metabolism; 6 patients from the cohort (2 EPOR-mutant, 2 HIF2A-mutant, and 2 VHL-mutant) were available for hepcidin and ERFE measurements.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "focus", "on", "the", "assessment", "of", "iron", "metabolism", ";", "6", "patients", "from", "the", "cohort", "(", "2", "EPOR-mutant", ",", "2", "HIF2A-mutant", ",", "and", "2", "VHL-mutant", ")", "were", "available", "for", "hepcidin", "and", "ERFE", "measurements", "." ] } ]
PMC11190062
Images were analyzed using Image Studio Software (LI-COR Biosciences).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "were", "analyzed", "using", "Image", "Studio", "Software", "(", "LI-COR", "Biosciences", ")", "." ] } ]
PMC9429973
Aims: This analysis evaluated effectiveness of BCX9930 in subjects completing at least 48 weeks of treatment at target dose of 400 mg BID or 500 mg BID.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "This", "analysis", "evaluated", "effectiveness", "of", "BCX9930", "in", "subjects", "completing", "at", "least", "48", "weeks", "of", "treatment", "at", "target", "dose", "of", "400", "mg", "BID", "or", "500", "mg", "BID", "." ] } ]
PMC11742231
The output of a convolutional layer can be computed as follows:8[12pt] $$ C_ = ( _^ _^ C_ W_ + b_j ) $$=σ∑k=1F∑l=1wC(i+l-1),k·Wj,k,l+bj is the output feature map at position i and channel j, is the activation function (e.g., ReLU), w is the size of the convolution filter (kernel), is the weight of the j-th filter at feature k and filter position l, and is the bias term for the j-th filter.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "output", "of", "a", "convolutional", "layer", "can", "be", "computed", "as", "follows:8[12pt", "]", "$", "$", "C", "_", "=", "(", "_", "^", "_", "^", "C", "_", "W", "_", "+", "b_j", ")", "$", "$", "=", "σ∑k=1F∑l=1wC(i+l-1),k·Wj", ",", "k", ",", "l+bj", "is", "the", "output", "feature", "map", "at", "position", "i", "and", "channel", "j", ",", "is", "the", "activation", "function", "(", "e.g.", ",", "ReLU", ")", ",", "w", "is", "the", "size", "of", "the", "convolution", "filter", "(", "kernel", ")", ",", "is", "the", "weight", "of", "the", "j-th", "filter", "at", "feature", "k", "and", "filter", "position", "l", ",", "and", "is", "the", "bias", "term", "for", "the", "j-th", "filter", "." ] } ]
PMC8382973
No significant abnormalities were found in the body surface, anus, or vagina by gross examination.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "significant", "abnormalities", "were", "found", "in", "the", "body", "surface", ",", "anus", ",", "or", "vagina", "by", "gross", "examination", "." ] } ]
PMC11628904
Images showing control and isotonic medium treated larvae after photoconversion of zone 1 tissue. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "showing", "control", "and", "isotonic", "medium", "treated", "larvae", "after", "photoconversion", "of", "zone", "1", "tissue", ".", "(" ] } ]
PMC7759933
As described before, HepG2 cells accumulated in the G1/G0 phase, due to arrested division in the G0 phase, which is especially noticeable at the initial density of 6000 cells/spheroid.
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "described", "before", ",", "HepG2", "cells", "accumulated", "in", "the", "G1/G0", "phase", ",", "due", "to", "arrested", "division", "in", "the", "G0", "phase", ",", "which", "is", "especially", "noticeable", "at", "the", "initial", "density", "of", "6000", "cells/spheroid", "." ] } ]
PMC9596868
Fig 3 Synergistic effect of quercetin and MST-312 in PA-1, A2780 and OVCAR3 cells. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Fig", "3", "Synergistic", "effect", "of", "quercetin", "and", "MST-312", "in", "PA-1", ",", "A2780", "and", "OVCAR3", "cells", ".", "(" ] } ]
PMC11472569
In addition to cell-to-cell contact, EVs can travel through body fluids, delivering their contents to distant target cells, thereby mediating systemic cellular communication in vivo.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "cell-to-cell", "contact", ",", "EVs", "can", "travel", "through", "body", "fluids", ",", "delivering", "their", "contents", "to", "distant", "target", "cells", ",", "thereby", "mediating", "systemic", "cellular", "communication", "in", "vivo", "." ] } ]
PMC9509578
Major obstacles to applying nucleic acid-based drugs are their stability, enzymatic degradation, poor membrane permeability and short half-life.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Major", "obstacles", "to", "applying", "nucleic", "acid-based", "drugs", "are", "their", "stability", ",", "enzymatic", "degradation", ",", "poor", "membrane", "permeability", "and", "short", "half-life", "." ] } ]
PMC10976516
However, it becomes clear that OVs are a very promising platform for combination therapy in the treatment of lung cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "becomes", "clear", "that", "OVs", "are", "a", "very", "promising", "platform", "for", "combination", "therapy", "in", "the", "treatment", "of", "lung", "cancer", "." ] } ]
PMC7823217
Consequently, it is also possible to produce different layers of cells including normal tissue specific cells, connective tissues and cancer cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "it", "is", "also", "possible", "to", "produce", "different", "layers", "of", "cells", "including", "normal", "tissue", "specific", "cells", ",", "connective", "tissues", "and", "cancer", "cells", "." ] } ]
PMC11802929
The statistical significance was determined using the two-sided Mann-Whitney U test, and p-values are annotated on all relevant plots with exact p-values provided unless p < 0.0001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statistical", "significance", "was", "determined", "using", "the", "two-sided", "Mann-Whitney", "U", "test", ",", "and", "p-values", "are", "annotated", "on", "all", "relevant", "plots", "with", "exact", "p-values", "provided", "unless", "p", "<", "0.0001", "." ] } ]
PMC11682525
Migration and characterization of human hair follicle stem cells (HFSCs).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Migration", "and", "characterization", "of", "human", "hair", "follicle", "stem", "cells", "(", "HFSCs", ")", "." ] } ]
PMC9577200
Saturated water disks were used as a control.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Saturated", "water", "disks", "were", "used", "as", "a", "control", "." ] } ]
PMC11753949
Somewhat similar synaptopodin-positive structures- pairs of ER cisterns connected by a synaptopodin-positive layer - have been observed to form next to neuronal cell bodies in response to high neuronal activity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Somewhat", "similar", "synaptopodin-positive", "structures-", "pairs", "of", "ER", "cisterns", "connected", "by", "a", "synaptopodin-positive", "layer", "-", "have", "been", "observed", "to", "form", "next", "to", "neuronal", "cell", "bodies", "in", "response", "to", "high", "neuronal", "activity", "." ] } ]
PMC9429973
Mean (SD) Hgb at baseline was 8.9 (0.8) g/dL, and 9 pts (36%) had transfusions in the past year.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mean", "(", "SD", ")", "Hgb", "at", "baseline", "was", "8.9", "(", "0.8", ")", "g/dL", ",", "and", "9", "pts", "(", "36", "%", ")", "had", "transfusions", "in", "the", "past", "year", "." ] } ]
PMC10994876
The quantity of secreted EPO was then assessed using the EPN kit (L2KEPN2) on the Siemens Immulite® 2000 XPi immunoassay system, an automated analyzer that utilizes chemiluminescent immunoassay technology.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "quantity", "of", "secreted", "EPO", "was", "then", "assessed", "using", "the", "EPN", "kit", "(", "L2KEPN2", ")", "on", "the", "Siemens", "Immulite", "®", "2000", "XPi", "immunoassay", "system", ",", "an", "automated", "analyzer", "that", "utilizes", "chemiluminescent", "immunoassay", "technology", "." ] } ]
PMC8540611
At low concentrations, AuNP13 did not penetrate the HL-60 and CEM-SS cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "At", "low", "concentrations", ",", "AuNP13", "did", "not", "penetrate", "the", "HL-60", "and", "CEM-SS", "cells", "." ] } ]
PMC11127909
mPTP is one of the most important participants in mitochondrial apoptosis, and it has been seen as a key factor in the development of many cancers .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "mPTP", "is", "one", "of", "the", "most", "important", "participants", "in", "mitochondrial", "apoptosis", ",", "and", "it", "has", "been", "seen", "as", "a", "key", "factor", "in", "the", "development", "of", "many", "cancers", "." ] } ]
PMC2944824
Apoptotic data are reported as percentage apoptosis, obtained by determining the numbers of apoptotic cells versus the total number of cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptotic", "data", "are", "reported", "as", "percentage", "apoptosis", ",", "obtained", "by", "determining", "the", "numbers", "of", "apoptotic", "cells", "versus", "the", "total", "number", "of", "cells", "." ] } ]
PMC10587429
As with any animal models, this model has advantages and limitations in its recapitulation of the human patient tumor microenvironment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "with", "any", "animal", "models", ",", "this", "model", "has", "advantages", "and", "limitations", "in", "its", "recapitulation", "of", "the", "human", "patient", "tumor", "microenvironment", "." ] } ]
PMC11787355
Tumor-bearing mice were then monitored routinely for tumor-related symptoms and measured for tumor growth with a caliper.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor-bearing", "mice", "were", "then", "monitored", "routinely", "for", "tumor-related", "symptoms", "and", "measured", "for", "tumor", "growth", "with", "a", "caliper", "." ] } ]
PMC9429973
Primary endpoints of the study are safety and RP2D determination (based on PK, PD, safety, tolerability, and preliminary activity).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "endpoints", "of", "the", "study", "are", "safety", "and", "RP2D", "determination", "(", "based", "on", "PK", ",", "PD", ",", "safety", ",", "tolerability", ",", "and", "preliminary", "activity", ")", "." ] } ]
PMC10820104
Cells were incubated at 37 °C in a humidified atmosphere supplemented with 5% CO2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "incubated", "at", "37", "°", "C", "in", "a", "humidified", "atmosphere", "supplemented", "with", "5", "%", "CO2", "." ] } ]
PMC11552389
A and B) The JASPAR software was used to predict putative sites of FOXN3 binding within the region upstream of the FSIP1 start codon. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "and", "B", ")", "The", "JASPAR", "software", "was", "used", "to", "predict", "putative", "sites", "of", "FOXN3", "binding", "within", "the", "region", "upstream", "of", "the", "FSIP1", "start", "codon", ".", "(" ] } ]
PMC11597291
In brief, cells were washed with PBS, harvested, and centrifuged in FACS tubes (1600 rpm, 5 min).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "cells", "were", "washed", "with", "PBS", ",", "harvested", ",", "and", "centrifuged", "in", "FACS", "tubes", "(", "1600", "rpm", ",", "5", "min", ")", "." ] } ]
PMC9919300
Mitochondria is the main organelle that oxidizes fatty acids and generates energy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mitochondria", "is", "the", "main", "organelle", "that", "oxidizes", "fatty", "acids", "and", "generates", "energy", "." ] } ]
PMC9429973
Results: We isolated exosomes from the sera of 24 healthy donors and 31 patients with PV.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "isolated", "exosomes", "from", "the", "sera", "of", "24", "healthy", "donors", "and", "31", "patients", "with", "PV", "." ] } ]
PMC10547921
Although the antibody–drug conjugates show effectiveness in treatment, the combination with highly toxic payloads is not necessarily excellent.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "antibody", "–", "drug", "conjugates", "show", "effectiveness", "in", "treatment", ",", "the", "combination", "with", "highly", "toxic", "payloads", "is", "not", "necessarily", "excellent", "." ] } ]
PMC2118063
In contrast to this rapidly expanding understanding of the contributions of IRF8 to myeloid development, function, and transformation, very little is known about the role played by this gene in lymphoid cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", "to", "this", "rapidly", "expanding", "understanding", "of", "the", "contributions", "of", "IRF8", "to", "myeloid", "development", ",", "function", ",", "and", "transformation", ",", "very", "little", "is", "known", "about", "the", "role", "played", "by", "this", "gene", "in", "lymphoid", "cells", "." ] } ]
PMC9429973
MRsc did not however improved TTNLT.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MRsc", "did", "not", "however", "improved", "TTNLT", "." ] } ]
PMC9429973
2020;4(19):4802-4811), ZO was found to be tolerable and associated with early signal of efficacy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2020;4(19):4802", "-", "4811", ")", ",", "ZO", "was", "found", "to", "be", "tolerable", "and", "associated", "with", "early", "signal", "of", "efficacy", "." ] } ]
PMC9429973
12.2% (claims) and 4.9% (EHR) of patients received stem cell transplant prior to T0.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "12.2", "%", "(", "claims", ")", "and", "4.9", "%", "(", "EHR", ")", "of", "patients", "received", "stem", "cell", "transplant", "prior", "to", "T0", "." ] } ]
PMC11714165
After that, the mixture was vortexed and sonicated on ice for 10 min using a VCX130 sonicator (Sonics, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "that", ",", "the", "mixture", "was", "vortexed", "and", "sonicated", "on", "ice", "for", "10", "min", "using", "a", "VCX130", "sonicator", "(", "Sonics", ",", "USA", ")", "." ] } ]
PMC9065483
The microarray data that were analyzed have previously been deposited in the NCBI-Gene Expression Omnibus database (GEO: GSE97327).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "microarray", "data", "that", "were", "analyzed", "have", "previously", "been", "deposited", "in", "the", "NCBI-Gene", "Expression", "Omnibus", "database", "(", "GEO", ":", "GSE97327", ")", "." ] } ]
PMC9429973
J. Zaleska, P. Kwaśnik, M. Paziewska, J. Purkot, A. Szabelak, M. Jurek, N. Masny, I. Dziatkiewicz, P. Własiuk, K. Skórka, G. Stasiak, B. Pronobis-Szczylik, A. Piebiak, A. Szymczyk, K. Jarosz-Chudzik, L. Bołkun, K. Kozłowska, J. Piszcz, E. Subocz, J. Hałka, M. Bator, E. Kalicińska, T. Wróbel, L. Usnarska-Zubkiewicz, J. Rybka, I. Dereń-Wagemann, M. Szyca-Śmieszniak, J. Dybko, I. Hus, B. Puła, E. Cichocka, M. Rymko, D. Zduńczyk, M. Ziarkiewicz, G. Basak, L. Bullinger, K. Giannopoulos Department of Experimental Hematooncology, Medical University of Lublin; Department of Hematology, St John’s Cancer Centre; Department of Clinical Transplantology, Medical University of Lublin, Lublin; Department of Hematology, Medical University of Bialystok, Bialystok; Department of Hematology, Warmian-Masurian Cancer Center of the Ministry of the Interior and Administration’s Hospital, Olsztyn; Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University; Department of Hematology and Transplantation, Lower Silesian Center of Oncology, Wroclaw; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw; Department of Hematology and Bone Marrow Transplantation, Nicolaus Copernicus Hospital, Torun; Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Poland; Department of Hematology, Oncology, and Tumor Immunology, Charité – Universitätsmedizin Berlin; German Cancer Consortium, Berlin, Germany Background: Multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients have increased morbidity and mortality rates of COVID-19 due to immunosuppression associated with the disease and ongoing therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "J.", "Zaleska", ",", "P.", "Kwaśnik", ",", "M.", "Paziewska", ",", "J.", "Purkot", ",", "A.", "Szabelak", ",", "M.", "Jurek", ",", "N.", "Masny", ",", "I.", "Dziatkiewicz", ",", "P.", "Własiuk", ",", "K.", "Skórka", ",", "G.", "Stasiak", ",", "B.", "Pronobis-Szczylik", ",", "A.", "Piebiak", ",", "A.", "Szymczyk", ",", "K.", "Jarosz-Chudzik", ",", "L.", "Bołkun", ",", "K.", "Kozłowska", ",", "J.", "Piszcz", ",", "E.", "Subocz", ",", "J.", "Hałka", ",", "M.", "Bator", ",", "E.", "Kalicińska", ",", "T.", "Wróbel", ",", "L.", "Usnarska-Zubkiewicz", ",", "J.", "Rybka", ",", "I.", "Dereń-Wagemann", ",", "M.", "Szyca-Śmieszniak", ",", "J.", "Dybko", ",", "I.", "Hus", ",", "B.", "Puła", ",", "E.", "Cichocka", ",", "M.", "Rymko", ",", "D.", "Zduńczyk", ",", "M.", "Ziarkiewicz", ",", "G.", "Basak", ",", "L.", "Bullinger", ",", "K.", "Giannopoulos", "Department", "of", "Experimental", "Hematooncology", ",", "Medical", "University", "of", "Lublin", ";", "Department", "of", "Hematology", ",", "St", "John", "’s", "Cancer", "Centre", ";", "Department", "of", "Clinical", "Transplantology", ",", "Medical", "University", "of", "Lublin", ",", "Lublin", ";", "Department", "of", "Hematology", ",", "Medical", "University", "of", "Bialystok", ",", "Bialystok", ";", "Department", "of", "Hematology", ",", "Warmian-Masurian", "Cancer", "Center", "of", "the", "Ministry", "of", "the", "Interior", "and", "Administration", "’s", "Hospital", ",", "Olsztyn", ";", "Department", "of", "Hematology", ",", "Blood", "Neoplasms", "and", "Bone", "Marrow", "Transplantation", ",", "Wroclaw", "Medical", "University", ";", "Department", "of", "Hematology", "and", "Transplantation", ",", "Lower", "Silesian", "Center", "of", "Oncology", ",", "Wroclaw", ";", "Department", "of", "Hematology", ",", "Institute", "of", "Hematology", "and", "Transfusion", "Medicine", ",", "Warsaw", ";", "Department", "of", "Hematology", "and", "Bone", "Marrow", "Transplantation", ",", "Nicolaus", "Copernicus", "Hospital", ",", "Torun", ";", "Department", "of", "Hematology", ",", "Transplantation", "and", "Internal", "Medicine", ",", "Medical", "University", "of", "Warsaw", ",", "Warsaw", ",", "Poland", ";", "Department", "of", "Hematology", ",", "Oncology", ",", "and", "Tumor", "Immunology", ",", "Charité", "–", "Universitätsmedizin", "Berlin", ";", "German", "Cancer", "Consortium", ",", "Berlin", ",", "Germany", "Background", ":", "Multiple", "myeloma", "(", "MM", ")", "and", "chronic", "lymphocytic", "leukemia", "(", "CLL", ")", "patients", "have", "increased", "morbidity", "and", "mortality", "rates", "of", "COVID-19", "due", "to", "immunosuppression", "associated", "with", "the", "disease", "and", "ongoing", "therapy", "." ] } ]
PMC9429973
Results: Our study demonstrated that S100a9 may inhibit MDS associated tumor escape via PD-1/PD-L1 blockade through PI3K/Akt/mTOR signaling pathway activation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Our", "study", "demonstrated", "that", "S100a9", "may", "inhibit", "MDS", "associated", "tumor", "escape", "via", "PD-1/PD-L1", "blockade", "through", "PI3K/Akt/mTOR", "signaling", "pathway", "activation", "." ] } ]
PMC11548041
Next, we assessed whether aptamer-functionalized nanovesicles could enhance the delivery of therapeutic cargo to EpCAM-expressing CCA cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "assessed", "whether", "aptamer-functionalized", "nanovesicles", "could", "enhance", "the", "delivery", "of", "therapeutic", "cargo", "to", "EpCAM-expressing", "CCA", "cells", "." ] } ]
PMC10607604
Several mechanisms may explain PTPN13’s effect on platinum salt sensitivity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "mechanisms", "may", "explain", "PTPN13", "’s", "effect", "on", "platinum", "salt", "sensitivity", "." ] } ]
PMC11730305
In this way, more biocompatible, stable, and effective nanoproducts can be obtained.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "way", ",", "more", "biocompatible", ",", "stable", ",", "and", "effective", "nanoproducts", "can", "be", "obtained", "." ] } ]
PMC11012012
Anti-SLAMF7/CD319 monoclonal antibody strongly enhanced the proliferation of both freshly isolated and activated B cells, especially when B cells were activated by anti-CD40 monoclonal antibodies and/or human recombinant IL-4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-SLAMF7/CD319", "monoclonal", "antibody", "strongly", "enhanced", "the", "proliferation", "of", "both", "freshly", "isolated", "and", "activated", "B", "cells", ",", "especially", "when", "B", "cells", "were", "activated", "by", "anti-CD40", "monoclonal", "antibodies", "and/or", "human", "recombinant", "IL-4", "." ] } ]
PMC9351137
B Mock, left panel; multipolar spindles (MS), middle panel; chromosome misalignments (CM), right panel.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Mock", ",", "left", "panel", ";", "multipolar", "spindles", "(", "MS", ")", ",", "middle", "panel", ";", "chromosome", "misalignments", "(", "CM", ")", ",", "right", "panel", "." ] } ]
PMC10440586
The intersection of highly correlated genes in the TCGA and CGGA datasets was used for over-representation analysis which was demonstrated in Supplementary Figure 3.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "intersection", "of", "highly", "correlated", "genes", "in", "the", "TCGA", "and", "CGGA", "datasets", "was", "used", "for", "over-representation", "analysis", "which", "was", "demonstrated", "in", "Supplementary", "Figure", "3", "." ] } ]
PMC11733919
At selected time points, cells were dual-stained using Annexin V staining (apoptosis) and 7-AAD staining (necrosis) using Muse Annexin V and Dead Cell Assay Kit according to the manufacturer’s instructions (Luminex Corporation, Austin, TX, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "selected", "time", "points", ",", "cells", "were", "dual-stained", "using", "Annexin", "V", "staining", "(", "apoptosis", ")", "and", "7-AAD", "staining", "(", "necrosis", ")", "using", "Muse", "Annexin", "V", "and", "Dead", "Cell", "Assay", "Kit", "according", "to", "the", "manufacturer", "’s", "instructions", "(", "Luminex", "Corporation", ",", "Austin", ",", "TX", ",", "USA", ")", "." ] } ]
PMC11144200
n = 5, **P < 0.01, ***P < 0.001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "5", ",", "*", "*", "P", "<", "0.01", ",", "*", "*", "*", "P", "<", "0.001", "." ] } ]
PMC11537649
The cell cycle is the fundamental process of cell life activities, involving the participation of multiple genes and proteins, which in turn forms a complex molecular signaling network system.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "cycle", "is", "the", "fundamental", "process", "of", "cell", "life", "activities", ",", "involving", "the", "participation", "of", "multiple", "genes", "and", "proteins", ",", "which", "in", "turn", "forms", "a", "complex", "molecular", "signaling", "network", "system", "." ] } ]
PMC11711663
The selected model in Table 4 revealed several notable associations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "selected", "model", "in", "Table", "4", "revealed", "several", "notable", "associations", "." ] } ]
PMC10812665
The dearth of screen hit characterization studies is astonishing, given that mechanistic characterization of toxicants has a long tradition in toxicology.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dearth", "of", "screen", "hit", "characterization", "studies", "is", "astonishing", ",", "given", "that", "mechanistic", "characterization", "of", "toxicants", "has", "a", "long", "tradition", "in", "toxicology", "." ] } ]
PMC8193813
These response times are both shorter than those measured simultaneously in the laboratory with CEM (Ametek 9000 RM, Pittsburgh, PA, USA) at 37 and 50s, respectively, for NO and NO2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "response", "times", "are", "both", "shorter", "than", "those", "measured", "simultaneously", "in", "the", "laboratory", "with", "CEM", "(", "Ametek", "9000", "RM", ",", "Pittsburgh", ",", "PA", ",", "USA", ")", "at", "37", "and", "50s", ",", "respectively", ",", "for", "NO", "and", "NO2", "." ] } ]
PMC9429973
Most importantly, the identified DEGs are disclosing novel potential therapeutic targets to design innovative RNA-based therapies for T-LGLL patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "importantly", ",", "the", "identified", "DEGs", "are", "disclosing", "novel", "potential", "therapeutic", "targets", "to", "design", "innovative", "RNA-based", "therapies", "for", "T-LGLL", "patients", "." ] } ]
PMC10553685
Additionally, estrogen-only hormone replacement therapy increases the risk of ILC, but not the more common invasive ductal carcinoma (IDC), highlighting a potentially unique role for estrogen in ILC initiation and progression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "estrogen-only", "hormone", "replacement", "therapy", "increases", "the", "risk", "of", "ILC", ",", "but", "not", "the", "more", "common", "invasive", "ductal", "carcinoma", "(", "IDC", ")", ",", "highlighting", "a", "potentially", "unique", "role", "for", "estrogen", "in", "ILC", "initiation", "and", "progression", "." ] } ]
PMC10900886
Cells were fixed and permeabilized with BD Cytofix/Cytoperm Fixation and Permeabilization kit according to the manufacturer's instructions (BD Biosciences).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "fixed", "and", "permeabilized", "with", "BD", "Cytofix/Cytoperm", "Fixation", "and", "Permeabilization", "kit", "according", "to", "the", "manufacturer", "'s", "instructions", "(", "BD", "Biosciences", ")", "." ] } ]
PMC11297139
f Representative confocal images of 293T cells transfected with different forms of recombinant GFP-ARID1A constructs, including GFP, GFP-ARID1A, GFP-PrLD1, GFP-ARID, GFP-PrLD2, GFP-Pfam, GFP-ARID1A PrLD(Y/S), and GFP-ΔDD mutant.
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "Representative", "confocal", "images", "of", "293", "T", "cells", "transfected", "with", "different", "forms", "of", "recombinant", "GFP-ARID1A", "constructs", ",", "including", "GFP", ",", "GFP-ARID1A", ",", "GFP-PrLD1", ",", "GFP-ARID", ",", "GFP-PrLD2", ",", "GFP-Pfam", ",", "GFP-ARID1A", "PrLD(Y/S", ")", ",", "and", "GFP-ΔDD", "mutant", "." ] } ]
PMC9429973
Subgroup analyses showed that sAML-type mutations conferred a significantly poorer DFS (median, 0 years vs. 0.5, P=0.03) and a trend of shorter OS (0.8 years vs. 1.1 years, P=0.08) in older patients, and a significantly worse OS (not reached vs. not reached, P=0.03) and a trend of shorter DFS (0.7 years vs. 1.0 years, P=0.16) in younger patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subgroup", "analyses", "showed", "that", "sAML-type", "mutations", "conferred", "a", "significantly", "poorer", "DFS", "(", "median", ",", "0", "years", "vs.", "0.5", ",", "P=0.03", ")", "and", "a", "trend", "of", "shorter", "OS", "(", "0.8", "years", "vs.", "1.1", "years", ",", "P=0.08", ")", "in", "older", "patients", ",", "and", "a", "significantly", "worse", "OS", "(", "not", "reached", "vs.", "not", "reached", ",", "P=0.03", ")", "and", "a", "trend", "of", "shorter", "DFS", "(", "0.7", "years", "vs.", "1.0", "years", ",", "P=0.16", ")", "in", "younger", "patients", "." ] } ]
PMC6803987
The HBx protein was evaluated by using an improved method of reference .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "HBx", "protein", "was", "evaluated", "by", "using", "an", "improved", "method", "of", "reference", "." ] } ]
PMC11790971
Correlation features and FLIM modality played pivotal roles in early classification.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "features", "and", "FLIM", "modality", "played", "pivotal", "roles", "in", "early", "classification", "." ] } ]
PMC11486946
An 830 nm laser is used as the light source, and its incident angle is switched between two values using a Galvano mirror with a frequency of 10 Hz.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "830", "nm", "laser", "is", "used", "as", "the", "light", "source", ",", "and", "its", "incident", "angle", "is", "switched", "between", "two", "values", "using", "a", "Galvano", "mirror", "with", "a", "frequency", "of", "10", "Hz", "." ] } ]
PMC11772585
H The mRNA levels of ATF4 in cells transfected with WT METTL1 or Mut METTL1 were assessed by qRT-PCR (n = 6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "The", "mRNA", "levels", "of", "ATF4", "in", "cells", "transfected", "with", "WT", "METTL1", "or", "Mut", "METTL1", "were", "assessed", "by", "qRT-PCR", "(", "n", "=", "6", ")", "." ] } ]
PMC10551595
Followed by their passive transport into cells, GCCs bind their cytoplasmic receptors and apply their cytotoxic effects. ,
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Followed", "by", "their", "passive", "transport", "into", "cells", ",", "GCCs", "bind", "their", "cytoplasmic", "receptors", "and", "apply", "their", "cytotoxic", "effects", ".", "," ] } ]
PMC11684269
Despite many distinguished studies that emerged in the field of T cell metabolism, the majority focused on anti-tumor.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "many", "distinguished", "studies", "that", "emerged", "in", "the", "field", "of", "T", "cell", "metabolism", ",", "the", "majority", "focused", "on", "anti-tumor", "." ] } ]
PMC9429973
These findings may provide a theoretical foundation for improving the clinical treatment of AITL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "may", "provide", "a", "theoretical", "foundation", "for", "improving", "the", "clinical", "treatment", "of", "AITL", "." ] } ]
PMC11301242
This dysregulation of gene expression has also been confirmed in cell line samples with circular amplification (Fig. 5D, Supplementary Fig. 4D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "dysregulation", "of", "gene", "expression", "has", "also", "been", "confirmed", "in", "cell", "line", "samples", "with", "circular", "amplification", "(", "Fig.", "5D", ",", "Supplementary", "Fig.", "4D", ")", "." ] } ]
PMC11747949
In addition, mice bearing orthotopic 143B tumors were subjected to CCR2 antagonist treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "mice", "bearing", "orthotopic", "143B", "tumors", "were", "subjected", "to", "CCR2", "antagonist", "treatment", "." ] } ]
PMC8382973
The 0.1% HEC gel, 0.5% HEC gel, 1% HEC gel, 1.5% HEC gel, and 2% HEC gel were level 1, and the cell viability was 99.7%, 97.5%, 93.4%, 89.4%, and 83.5%, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "0.1", "%", "HEC", "gel", ",", "0.5", "%", "HEC", "gel", ",", "1", "%", "HEC", "gel", ",", "1.5", "%", "HEC", "gel", ",", "and", "2", "%", "HEC", "gel", "were", "level", "1", ",", "and", "the", "cell", "viability", "was", "99.7", "%", ",", "97.5", "%", ",", "93.4", "%", ",", "89.4", "%", ",", "and", "83.5", "%", ",", "respectively", "." ] } ]
PMC11269933
Artificial breeding program including broodstock conditioning, fertilization, and larval cultures, all of which were conducted in hatchery with 22-26°C and 31 ± 1 ‰ seawater.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Artificial", "breeding", "program", "including", "broodstock", "conditioning", ",", "fertilization", ",", "and", "larval", "cultures", ",", "all", "of", "which", "were", "conducted", "in", "hatchery", "with", "22", "-", "26", "°", "C", "and", "31", "±", "1", "‰", "seawater", "." ] } ]
PMC11604768
Dashed lines indicate an FDR threshold of 5%.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dashed", "lines", "indicate", "an", "FDR", "threshold", "of", "5", "%", "." ] } ]
PMC11155445
Reusability investigation demonstrated that the adsorption capacity of IIM declined after five adsorption and desorption cycles.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reusability", "investigation", "demonstrated", "that", "the", "adsorption", "capacity", "of", "IIM", "declined", "after", "five", "adsorption", "and", "desorption", "cycles", "." ] } ]
PMC11730311
IC50 values are presented in figure legends as mean ± range.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IC50", "values", "are", "presented", "in", "figure", "legends", "as", "mean", "±", "range", "." ] } ]
PMC11286266
The Coat Protein Complex II (COPII)-coated vesicles have been implicated in the trafficking of ATF6α (Schindler and Schekman, 2009; Lynch et al., 2012) and the ATF6α_LD’s N-glycosylation state has also been proposed to influence its ER trafficking (Hong et al., 2004), yet the details of these processed remain incompletely understood.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Coat", "Protein", "Complex", "II", "(COPII)-coated", "vesicles", "have", "been", "implicated", "in", "the", "trafficking", "of", "ATF6α", "(", "Schindler", "and", "Schekman", ",", "2009", ";", "Lynch", "et", "al.", ",", "2012", ")", "and", "the", "ATF6α_LD", "’s", "N-glycosylation", "state", "has", "also", "been", "proposed", "to", "influence", "its", "ER", "trafficking", "(", "Hong", "et", "al.", ",", "2004", ")", ",", "yet", "the", "details", "of", "these", "processed", "remain", "incompletely", "understood", "." ] } ]
PMC11730305
Initially, the cells was grown (3.0 × 10 cells/well) were treated with the nanoparticles for 24 h. Next, the cells were harvested and treated with 2’,7’-dichlorodihydrofluorescein (H2DCF) for 60 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initially", ",", "the", "cells", "was", "grown", "(", "3.0", "×", "10", "cells/well", ")", "were", "treated", "with", "the", "nanoparticles", "for", "24", "h.", "Next", ",", "the", "cells", "were", "harvested", "and", "treated", "with", "2’,7’-dichlorodihydrofluorescein", "(", "H2DCF", ")", "for", "60", "min", "." ] } ]
PMC9429973
IRAK4 is critical in triggering inflammation, oncogenesis, and survival of cancer cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IRAK4", "is", "critical", "in", "triggering", "inflammation", ",", "oncogenesis", ",", "and", "survival", "of", "cancer", "cells", "." ] } ]
PMC8751435
The content of LDH release of 20‐μl supernatants was reflected by activity of LDH calculated according to the following equation: LDH concentration(U/L)=(Mean OD of test sample‐Mean OD of the control)(Mean OD of the standard‐Mean OD of the blank)×standard concentration(0.2μmol/ml).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "content", "of", "LDH", "release", "of", "20‐μl", "supernatants", "was", "reflected", "by", "activity", "of", "LDH", "calculated", "according", "to", "the", "following", "equation", ":", "LDH", "concentration(U/L)=(Mean", "OD", "of", "test", "sample‐Mean", "OD", "of", "the", "control)(Mean", "OD", "of", "the", "standard‐Mean", "OD", "of", "the", "blank)", "×", "standard", "concentration(0.2μmol/ml", ")", "." ] } ]
PMC11222184
The Enrichr online tool was used to analyze pathways including both downregulated and upregulated genes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Enrichr", "online", "tool", "was", "used", "to", "analyze", "pathways", "including", "both", "downregulated", "and", "upregulated", "genes", "." ] } ]
PMC11656657
We aimed at evaluating the preclinical efficacy of targeting sarcoma tumors using third-generation CAR.GD2 T-cells, which incorporates the costimulatory domains of CD28 and 4.1BB and the suicide gene inducible caspase-9, as safety switch .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "aimed", "at", "evaluating", "the", "preclinical", "efficacy", "of", "targeting", "sarcoma", "tumors", "using", "third-generation", "CAR.GD2", "T-cells", ",", "which", "incorporates", "the", "costimulatory", "domains", "of", "CD28", "and", "4.1BB", "and", "the", "suicide", "gene", "inducible", "caspase-9", ",", "as", "safety", "switch", "." ] } ]
PMC11365427
The reaction was terminated by adding the loading buffer and then boiling for 10 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "was", "terminated", "by", "adding", "the", "loading", "buffer", "and", "then", "boiling", "for", "10", "min", "." ] } ]
PMC11506670
The Q43K and E37K constructs were generated using an inverse PCR site-directed mutagenesis approach, with overlapping mutagenic primers oriented in opposite directions, followed by circularization of the amplicon via the region of overlap.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Q43", "K", "and", "E37", "K", "constructs", "were", "generated", "using", "an", "inverse", "PCR", "site-directed", "mutagenesis", "approach", ",", "with", "overlapping", "mutagenic", "primers", "oriented", "in", "opposite", "directions", ",", "followed", "by", "circularization", "of", "the", "amplicon", "via", "the", "region", "of", "overlap", "." ] } ]
PMC10957991
E-cadherin-red; TRPV4-green; DAPI-blue.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "E-cadherin-red", ";", "TRPV4-green", ";", "DAPI-blue", "." ] } ]
PMC11389534
While the majority of the UFM1 system is predominantly located at the cytosolic side of the endoplasmic reticulum (ER) membrane, UBA5 and UFC1 are distributed in the cytosol and nucleus.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "the", "majority", "of", "the", "UFM1", "system", "is", "predominantly", "located", "at", "the", "cytosolic", "side", "of", "the", "endoplasmic", "reticulum", "(", "ER", ")", "membrane", ",", "UBA5", "and", "UFC1", "are", "distributed", "in", "the", "cytosol", "and", "nucleus", "." ] } ]
PMC11040965
Activation of CD28 on multiple myeloma (MM) plasma cells, by binding to CD80 and CD86 on dendritic cells, decreases proteasome subunit expression in the tumor cells and thereby helps them evade being killed by CD8 T cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "CD28", "on", "multiple", "myeloma", "(", "MM", ")", "plasma", "cells", ",", "by", "binding", "to", "CD80", "and", "CD86", "on", "dendritic", "cells", ",", "decreases", "proteasome", "subunit", "expression", "in", "the", "tumor", "cells", "and", "thereby", "helps", "them", "evade", "being", "killed", "by", "CD8", "T", "cells", "." ] } ]
PMC11453018
Senescence induced by P300/CBP inhibition, whether via small molecules or knockdown, has been previously observed in various cancers, such as melanoma, non-small cell lung cancer, and breast cancer [51–53].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Senescence", "induced", "by", "P300/CBP", "inhibition", ",", "whether", "via", "small", "molecules", "or", "knockdown", ",", "has", "been", "previously", "observed", "in", "various", "cancers", ",", "such", "as", "melanoma", ",", "non-small", "cell", "lung", "cancer", ",", "and", "breast", "cancer", "[", "51–53", "]", "." ] } ]
PMC11701801
Cells were transfected with indicated siRNAs for 48 hours, reseeded, and transfected with the indicated siRNAs for an additional 48 hours.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "transfected", "with", "indicated", "siRNAs", "for", "48", "hours", ",", "reseeded", ",", "and", "transfected", "with", "the", "indicated", "siRNAs", "for", "an", "additional", "48", "hours", "." ] } ]
PMC11310713
However, as women age, they eventually lose their ovarian functions due to repeated menstrual cycles, leading to menopause.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "as", "women", "age", ",", "they", "eventually", "lose", "their", "ovarian", "functions", "due", "to", "repeated", "menstrual", "cycles", ",", "leading", "to", "menopause", "." ] } ]
PMC11678368
The complexes also displayed selective cytotoxicity towards cancer cells, with reduced toxicity to normal fibroblasts (BALB/3T3), supporting their potential as targeted anticancer agents.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "complexes", "also", "displayed", "selective", "cytotoxicity", "towards", "cancer", "cells", ",", "with", "reduced", "toxicity", "to", "normal", "fibroblasts", "(", "BALB/3T3", ")", ",", "supporting", "their", "potential", "as", "targeted", "anticancer", "agents", "." ] } ]
PMC11512230
Plant viruses have several advantages over other natural and artificially synthesized materials.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plant", "viruses", "have", "several", "advantages", "over", "other", "natural", "and", "artificially", "synthesized", "materials", "." ] } ]
PMC10440586
Compared with patients who received standard of care (SOC) alone, patients treated with nivolumab showed a significant upregulation of CD99 after dosing, suggesting that CD99 is a responsive factor to ICB therapy (Fig. 5D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compared", "with", "patients", "who", "received", "standard", "of", "care", "(", "SOC", ")", "alone", ",", "patients", "treated", "with", "nivolumab", "showed", "a", "significant", "upregulation", "of", "CD99", "after", "dosing", ",", "suggesting", "that", "CD99", "is", "a", "responsive", "factor", "to", "ICB", "therapy", "(", "Fig.", "5D", ")", "." ] } ]