OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11637820	The Indian subcontinent has various ethnic and cultural groups and experiences a wide range of climatic conditions from arid deserts to humid tropical regions, making it exceptionally climatically diverse, while antimicrobial resistance arises from the overuse of antibiotics .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Indian", "subcontinent", "has", "various", "ethnic", "and", "cultural", "groups", "and", "experiences", "a", "wide", "range", "of", "climatic", "conditions", "from", "arid", "deserts", "to", "humid", "tropical", "regions", ",", "making", "it", "exceptionally", "climatically", "diverse", ",", "while", "antimicrobial", "resistance", "arises", "from", "the", "overuse", "of", "antibiotics", "." ] } ]
PMC11551844	Each cell line was incubated in Falcon T-25 vented tissue flasks (Corning Inc., NY) in DMEM supplemented with fetal bovine serum (10%) and penicillin/streptomycin (100 U mL) at 37 °C in air with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "cell", "line", "was", "incubated", "in", "Falcon", "T-25", "vented", "tissue", "flasks", "(", "Corning", "Inc.", ",", "NY", ")", "in", "DMEM", "supplemented", "with", "fetal", "bovine", "serum", "(", "10", "%", ")", "and", "penicillin/streptomycin", "(", "100", "U", "mL", ")", "at", "37", "°", "C", "in", "air", "with", "5", "%", "CO2", "." ] } ]
PMC11502066	GPR30 is a membranous estrogen receptor that functions independently of the classical nuclear estrogen receptors, ERα and ERβ, and mediates both rapid non-genomic signaling via multiple intracellular pathways as well as transcriptional events .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GPR30", "is", "a", "membranous", "estrogen", "receptor", "that", "functions", "independently", "of", "the", "classical", "nuclear", "estrogen", "receptors", ",", "ERα", "and", "ERβ", ",", "and", "mediates", "both", "rapid", "non-genomic", "signaling", "via", "multiple", "intracellular", "pathways", "as", "well", "as", "transcriptional", "events", "." ] } ]
PMC11285179	The separated cells were cultured in F12K medium (Gibco, LifeTech, USA) containing 10% fetal bovine serum (Gibco, Life Tech, USA) with 100 U/mL penicillin and 100 μg/mL streptomycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "separated", "cells", "were", "cultured", "in", "F12", "K", "medium", "(", "Gibco", ",", "LifeTech", ",", "USA", ")", "containing", "10", "%", "fetal", "bovine", "serum", "(", "Gibco", ",", "Life", "Tech", ",", "USA", ")", "with", "100", "U/mL", "penicillin", "and", "100", "μg/mL", "streptomycin", "." ] } ]
PMC11745823	Additionally, it promotes tumour proliferation by inhibiting apoptosis and accelerating cell cycle progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "it", "promotes", "tumour", "proliferation", "by", "inhibiting", "apoptosis", "and", "accelerating", "cell", "cycle", "progression", "." ] } ]
PMC11711871	Under NSD conditions, the relaxation induced by DEA/NO was slightly but significantly increased in GR rats compared to wild-type rats (Fig. 6E) with a greater AUC (Fig. 6F), while under HSD conditions, no difference was found between the two genotypes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "NSD", "conditions", ",", "the", "relaxation", "induced", "by", "DEA/NO", "was", "slightly", "but", "significantly", "increased", "in", "GR", "rats", "compared", "to", "wild-type", "rats", "(", "Fig.", "6E", ")", "with", "a", "greater", "AUC", "(", "Fig.", "6F", ")", ",", "while", "under", "HSD", "conditions", ",", "no", "difference", "was", "found", "between", "the", "two", "genotypes", "." ] } ]
PMC11322866	Recent studies suggested that RRM2 may play an important role as a bridge between senescence and cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "suggested", "that", "RRM2", "may", "play", "an", "important", "role", "as", "a", "bridge", "between", "senescence", "and", "cancer", "." ] } ]
PMC11472569	Research by Hekmatirad et al. showed that GW4869 effectively prevents the efflux of PEGylated liposomal doxorubicin (PLD) and increases U937 cell sensitivity to PLD’s cytotoxic effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "by", "Hekmatirad", "et", "al.", "showed", "that", "GW4869", "effectively", "prevents", "the", "efflux", "of", "PEGylated", "liposomal", "doxorubicin", "(", "PLD", ")", "and", "increases", "U937", "cell", "sensitivity", "to", "PLD", "’s", "cytotoxic", "effects", "." ] } ]
PMC10297204	There was no significant difference in latency between the control group (1.45 ± 0.11 ms) and the 30E group (1.40 ± 0.08 ms; p = 0.98; Figure 6A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "was", "no", "significant", "difference", "in", "latency", "between", "the", "control", "group", "(", "1.45", "±", "0.11", "ms", ")", "and", "the", "30E", "group", "(", "1.40", "±", "0.08", "ms", ";", "p", "=", "0.98", ";", "Figure", "6A", ")", "." ] } ]
PMC5810978	We did not observe significant RNA level increases for HuSaV and BoNoV under our test conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "did", "not", "observe", "significant", "RNA", "level", "increases", "for", "HuSaV", "and", "BoNoV", "under", "our", "test", "conditions", "." ] } ]
PMC7987994	Significance codes according to p value: 0 ‘*’0.001 ‘’0.01 ‘*’0.05 (two-sample t-test).Figure 4Relative metabolic activity of L929 cells (resazurin assay) after 24 h incubation with extracts of Mg_HF_SPS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Significance", "codes", "according", "to", "p", "value", ":", "0", "‘", "", "", "", "’", "0.001", "‘", "", "", "’", "0.01", "‘", "", "’", "0.05", "(", "two-sample", "t-test).Figure", "4Relative", "metabolic", "activity", "of", "L929", "cells", "(", "resazurin", "assay", ")", "after", "24", "h", "incubation", "with", "extracts", "of", "Mg_HF_SPS", "." ] } ]
PMC11271278	Expression levels were normalized to cells treated with a non-targeting sgRNA (NT1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "levels", "were", "normalized", "to", "cells", "treated", "with", "a", "non-targeting", "sgRNA", "(", "NT1", ")", "." ] } ]
PMC9429973	Sixty percent of patients (n=53) had an intermediate-high or high IPI score-risk and 40% (n=35) showed low IPI score-risk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sixty", "percent", "of", "patients", "(", "n=53", ")", "had", "an", "intermediate-high", "or", "high", "IPI", "score-risk", "and", "40", "%", "(", "n=35", ")", "showed", "low", "IPI", "score-risk", "." ] } ]
PMC9509578	Antibody-functionalized metal nanosystems can actively target and recognize multidrug-resistant tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antibody-functionalized", "metal", "nanosystems", "can", "actively", "target", "and", "recognize", "multidrug-resistant", "tumor", "cells", "." ] } ]
PMC11599565	OVCAR-3 cells exposed to cisplatin for 14 days revealed profound changes in the cell morphology towards “neuronal” phenotype.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OVCAR-3", "cells", "exposed", "to", "cisplatin", "for", "14", "days", "revealed", "profound", "changes", "in", "the", "cell", "morphology", "towards", "“", "neuronal", "”", "phenotype", "." ] } ]
PMC9429973	Socioeconomic factors including insurance status, level of education and median household income per zip code, and facility type appear to be associated with outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Socioeconomic", "factors", "including", "insurance", "status", ",", "level", "of", "education", "and", "median", "household", "income", "per", "zip", "code", ",", "and", "facility", "type", "appear", "to", "be", "associated", "with", "outcomes", "." ] } ]
PMC5673060	The low percentage of phosphorylation changes observed in our study may be due to a number of factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "low", "percentage", "of", "phosphorylation", "changes", "observed", "in", "our", "study", "may", "be", "due", "to", "a", "number", "of", "factors", "." ] } ]
PMC11363012	Targeted and untargeted mass spectrometry data are then processed to obtain quantitative and qualitative information (step 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Targeted", "and", "untargeted", "mass", "spectrometry", "data", "are", "then", "processed", "to", "obtain", "quantitative", "and", "qualitative", "information", "(", "step", "5", ")", "." ] } ]
PMC9429973	Our findings help further define therapy-associated ALL as a distinct entity, but also highlight the need for a better molecular understanding of its specific disease evolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "help", "further", "define", "therapy-associated", "ALL", "as", "a", "distinct", "entity", ",", "but", "also", "highlight", "the", "need", "for", "a", "better", "molecular", "understanding", "of", "its", "specific", "disease", "evolution", "." ] } ]
PMC11098378	P. syringae is a plant pathogen that has been an important model for understanding plant immunity to bacterial infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P.", "syringae", "is", "a", "plant", "pathogen", "that", "has", "been", "an", "important", "model", "for", "understanding", "plant", "immunity", "to", "bacterial", "infection", "." ] } ]
PMC11365983	Immunofluorescent staining demonstrated ~ 1.9-fold reductions in both total PDGFRα, and the level of the active autophosphorylated form, in E14.5 Foxc1 embryos compared to wild type littermates (PDGFRα: Foxc1 0.55, WT 1.0, P = 2.6 × 10; pY754-PDGFRα: Foxc1 0.54, WT 1.0, P = 0.048; Fig. 8A–G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunofluorescent", "staining", "demonstrated", "~", "1.9-fold", "reductions", "in", "both", "total", "PDGFRα", ",", "and", "the", "level", "of", "the", "active", "autophosphorylated", "form", ",", "in", "E14.5", "Foxc1", "embryos", "compared", "to", "wild", "type", "littermates", "(", "PDGFRα", ":", "Foxc1", "0.55", ",", "WT", "1.0", ",", "P", "=", "2.6", "×", "10", ";", "pY754-PDGFRα", ":", "Foxc1", "0.54", ",", "WT", "1.0", ",", "P", "=", "0.048", ";", "Fig.", "8A", "–", "G", ")", "." ] } ]
PMC11222184	The protein expression (A) changes in HSPs (HSP27, HSP70, HSP90) and the abundance HSPs in SH-SY5Y (B). (*	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "expression", "(", "A", ")", "changes", "in", "HSPs", "(", "HSP27", ",", "HSP70", ",", "HSP90", ")", "and", "the", "abundance", "HSPs", "in", "SH-SY5Y", "(", "B", ")", ".", "(", "*" ] } ]
PMC11583690	The solution was stirred at 80 °C, at 1,500 revolutions per minute (rpm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "solution", "was", "stirred", "at", "80", "°", "C", ",", "at", "1,500", "revolutions", "per", "minute", "(", "rpm", ")", "." ] } ]
PMC11509224	A total of 13 diterpenes were obtained from Dysidea sponges.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "13", "diterpenes", "were", "obtained", "from", "Dysidea", "sponges", "." ] } ]
PMC8623816	The RNA quality and integrity were determined by Agilent 2100 Bioanalyzer (Agilent 2100) and 1% agarose gel electrophoresis, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RNA", "quality", "and", "integrity", "were", "determined", "by", "Agilent", "2100", "Bioanalyzer", "(", "Agilent", "2100", ")", "and", "1", "%", "agarose", "gel", "electrophoresis", ",", "respectively", "." ] } ]
PMC9621239	Sn at each amino acid site in genotype-B clones. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sn", "at", "each", "amino", "acid", "site", "in", "genotype-B", "clones", ".", "(" ] } ]
PMC9587298	The incubation of caffeic acid with MGO resulted in two compounds corresponding to negative ions at m/z 251 and 323 that were attributed to the formation of mono- and di-MGO adducts of caffeic acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "incubation", "of", "caffeic", "acid", "with", "MGO", "resulted", "in", "two", "compounds", "corresponding", "to", "negative", "ions", "at", "m/z", "251", "and", "323", "that", "were", "attributed", "to", "the", "formation", "of", "mono-", "and", "di-MGO", "adducts", "of", "caffeic", "acid", "." ] } ]
PMC9599726	Contingency tables and Freeman–Halton extensions of Fisher’s test were performed to study the relationship between TFRC expression and non-continuous variables, such as tumor location, sex, mitotic figures, histological type, risk classification, YAP-ir, YAP activation, and KIT-ir.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Contingency", "tables", "and", "Freeman", "–", "Halton", "extensions", "of", "Fisher", "’s", "test", "were", "performed", "to", "study", "the", "relationship", "between", "TFRC", "expression", "and", "non-continuous", "variables", ",", "such", "as", "tumor", "location", ",", "sex", ",", "mitotic", "figures", ",", "histological", "type", ",", "risk", "classification", ",", "YAP-ir", ",", "YAP", "activation", ",", "and", "KIT-ir", "." ] } ]
PMC10899471	MiR-939-3p mimics or inhibitors, and negative controls were purchased from Tsingke Biotechnology, which were listed in Supplementary Table S3 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MiR-939", "-", "3p", "mimics", "or", "inhibitors", ",", "and", "negative", "controls", "were", "purchased", "from", "Tsingke", "Biotechnology", ",", "which", "were", "listed", "in", "Supplementary", "Table", "S3", "." ] } ]
PMC7154001	These studies involved a total of 57 (57.0%) conventional anticancer drugs/synthetic anticancer candidates,6,13–58 22 (22.0%) studies for small-molecules targeted therapy,4,5,59–70 and 21 (21.0%) studies for herb-derived compounds with anticancer activities2,3,7,9,71–83 (Tables 1–3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "studies", "involved", "a", "total", "of", "57", "(", "57.0", "%", ")", "conventional", "anticancer", "drugs/synthetic", "anticancer", "candidates,6,13–58", "22", "(", "22.0", "%", ")", "studies", "for", "small-molecules", "targeted", "therapy,4,5,59–70", "and", "21", "(", "21.0", "%", ")", "studies", "for", "herb-derived", "compounds", "with", "anticancer", "activities2,3,7,9,71–83", "(", "Tables", "1–3", ")", "." ] } ]
PMC8193046	The corresponding IC50 values of compounds 16–25 can be found in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "corresponding", "IC50", "values", "of", "compounds", "16–25", "can", "be", "found", "in", "Table", "1", "." ] } ]
PMC11555465	Bladder cancer is a prevalent urological malignancy with a poor prognosis in the advanced/metastatic stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bladder", "cancer", "is", "a", "prevalent", "urological", "malignancy", "with", "a", "poor", "prognosis", "in", "the", "advanced/metastatic", "stage", "." ] } ]
PMC9429973	The adherence to treatment it is significantly higher in patients older than 45 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "adherence", "to", "treatment", "it", "is", "significantly", "higher", "in", "patients", "older", "than", "45", "years", "." ] } ]
PMC10213199	The gene showed the highest expression during the G0/G1 phase, whereas it was downregulated after the G1 phase .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gene", "showed", "the", "highest", "expression", "during", "the", "G0/G1", "phase", ",", "whereas", "it", "was", "downregulated", "after", "the", "G1", "phase", "." ] } ]
PMC6643347	Only two companies (one in the United States and one in Russia) have so far succeeded in developing humic substance-based drugs and in completing all the requisite preclinical and clinical trials of their safety and efficacy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "two", "companies", "(", "one", "in", "the", "United", "States", "and", "one", "in", "Russia", ")", "have", "so", "far", "succeeded", "in", "developing", "humic", "substance-based", "drugs", "and", "in", "completing", "all", "the", "requisite", "preclinical", "and", "clinical", "trials", "of", "their", "safety", "and", "efficacy", "." ] } ]
PMC11574271	Actin-Tracker Red-555 and DAPI were utilized for staining the cytoskeleton and nucleus, respectively, with representative images displayed in Fig. (G) and (H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Actin-Tracker", "Red-555", "and", "DAPI", "were", "utilized", "for", "staining", "the", "cytoskeleton", "and", "nucleus", ",", "respectively", ",", "with", "representative", "images", "displayed", "in", "Fig.", "(", "G", ")", "and", "(", "H", ")", "." ] } ]
PMC11267830	Moreover, DCAF15 cannot fully predict the efficacy of the antitumor action of indisulam.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "DCAF15", "can", "not", "fully", "predict", "the", "efficacy", "of", "the", "antitumor", "action", "of", "indisulam", "." ] } ]
PMC11347429	Principal component analysis of transcriptome expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Principal", "component", "analysis", "of", "transcriptome", "expression", "." ] } ]
PMC11538390	The prevalence was estimated by dividing the number of CP cases in each region by the total number of individuals in that region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prevalence", "was", "estimated", "by", "dividing", "the", "number", "of", "CP", "cases", "in", "each", "region", "by", "the", "total", "number", "of", "individuals", "in", "that", "region", "." ] } ]
PMC9429973	The BCR-ABL transcript was of the p190 type in 2 cases and p210 in 2 cases, while the molecular study was not done in the remaining case.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "BCR-ABL", "transcript", "was", "of", "the", "p190", "type", "in", "2", "cases", "and", "p210", "in", "2", "cases", ",", "while", "the", "molecular", "study", "was", "not", "done", "in", "the", "remaining", "case", "." ] } ]
PMC11538390	NS represents non-significant (P = 0.1212).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NS", "represents", "non-significant", "(", "P", "=", "0.1212", ")", "." ] } ]
PMC11726848	This cell type is a suitable model because radiotherapy has been widely used for the treatment of tumors of epidermal origin .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "cell", "type", "is", "a", "suitable", "model", "because", "radiotherapy", "has", "been", "widely", "used", "for", "the", "treatment", "of", "tumors", "of", "epidermal", "origin", "." ] } ]
PMC11789597	All viability assays were determined in triplicate and replicated in three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "viability", "assays", "were", "determined", "in", "triplicate", "and", "replicated", "in", "three", "independent", "experiments", "." ] } ]
PMC10813895	It discusses the lineage-specific expression of ELF5, its regulatory mechanisms, and its potential as a biomarker for breast-specific biological age and cancer risk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "discusses", "the", "lineage-specific", "expression", "of", "ELF5", ",", "its", "regulatory", "mechanisms", ",", "and", "its", "potential", "as", "a", "biomarker", "for", "breast-specific", "biological", "age", "and", "cancer", "risk", "." ] } ]
PMC11609529	Using YM-positive ES-2 cancer cells as a model, our knockdown and KO studies established that the YM fusion is critical for sustaining cell growth and survival in YM-positive cancer cells.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "YM-positive", "ES-2", "cancer", "cells", "as", "a", "model", ",", "our", "knockdown", "and", "KO", "studies", "established", "that", "the", "YM", "fusion", "is", "critical", "for", "sustaining", "cell", "growth", "and", "survival", "in", "YM-positive", "cancer", "cells", "." ] } ]
PMC2944824	Decreases in potential indicate that the mitochondrial membrane has become compromised and can begin to release cytochrome C. The decrease in potential was significantly greater in cultures from Hr knockout mice treated with thapsigargin and staurosporine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Decreases", "in", "potential", "indicate", "that", "the", "mitochondrial", "membrane", "has", "become", "compromised", "and", "can", "begin", "to", "release", "cytochrome", "C.", "The", "decrease", "in", "potential", "was", "significantly", "greater", "in", "cultures", "from", "Hr", "knockout", "mice", "treated", "with", "thapsigargin", "and", "staurosporine", "." ] } ]
PMC9118379	PepS-A for SG-A searching), 11–30 a.a. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PepS-A", "for", "SG-A", "searching", ")", ",", "11–30", "a.a", ".", "(" ] } ]
PMC11551844	Zeta potential values indicated that AuNPs-JC-2 was more stable than AuNPs-JDE, AuNPs-JDH and AuNPs-ansellone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zeta", "potential", "values", "indicated", "that", "AuNPs-JC-2", "was", "more", "stable", "than", "AuNPs-JDE", ",", "AuNPs-JDH", "and", "AuNPs-ansellone", "." ] } ]
PMC11746948	This suggests that contribution of 2-BP to enhancing ferroptosis susceptibility is unlikely to be through a broad regulation of lipid composition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "suggests", "that", "contribution", "of", "2-BP", "to", "enhancing", "ferroptosis", "susceptibility", "is", "unlikely", "to", "be", "through", "a", "broad", "regulation", "of", "lipid", "composition", "." ] } ]
PMC11139449	Homology-Independent Targeted Integration (HITI) combined with CRISPR enhances transgene integration rates in divid-ing and non-dividing CHO cells ( 13 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Homology-Independent", "Targeted", "Integration", "(", "HITI", ")", "combined", "with", "CRISPR", "enhances", "transgene", "integration", "rates", "in", "divid-ing", "and", "non-dividing", "CHO", "cells", "(", "13", ")", "." ] } ]
PMC11342785	In contrast, N-terminal TPPP fragments showed no light-dependent clustering onto MTs (Figs. 3B and S3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "N-terminal", "TPPP", "fragments", "showed", "no", "light-dependent", "clustering", "onto", "MTs", "(", "Figs.", "3B", "and", "S3B", ")", "." ] } ]
PMC11704834	Briefly, the lentiviral products were produced using the second-generation system by transfecting the 293T cell line with 1 µg of lentiviral plasmid, 1.2 µg of packaging plasmid, and 6.6 µl of Lipofectamine 2000 reagent (Invitrogen; Thermo Fisher Scientific, Inc.) in 250 µl OPTI-MEM (Invitrogen; Thermo Fisher Scientific, Inc.) and incubated at 37˚C humidified incubator with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "the", "lentiviral", "products", "were", "produced", "using", "the", "second-generation", "system", "by", "transfecting", "the", "293", "T", "cell", "line", "with", "1", "µg", "of", "lentiviral", "plasmid", ",", "1.2", "µg", "of", "packaging", "plasmid", ",", "and", "6.6", "µl", "of", "Lipofectamine", "2000", "reagent", "(", "Invitrogen", ";", "Thermo", "Fisher", "Scientific", ",", "Inc.", ")", "in", "250", "µl", "OPTI-MEM", "(", "Invitrogen", ";", "Thermo", "Fisher", "Scientific", ",", "Inc.", ")", "and", "incubated", "at", "37˚C", "humidified", "incubator", "with", "5", "%", "CO2", "." ] } ]
PMC5673955	Membranes were washed in Tris‐buffered saline, pH 7.6 with 0.1% Tween‐20 (Invitrogen) and incubated with secondary antibodies conjugated with horseradish peroxidase (Cell Signaling, Danvers, MA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Membranes", "were", "washed", "in", "Tris‐buffered", "saline", ",", "pH", "7.6", "with", "0.1", "%", "Tween‐20", "(", "Invitrogen", ")", "and", "incubated", "with", "secondary", "antibodies", "conjugated", "with", "horseradish", "peroxidase", "(", "Cell", "Signaling", ",", "Danvers", ",", "MA", ")", "." ] } ]
PMC9429973	We then dichotomised D0 CRP to determine whether we could identify a practically useful cut-off to predict HGT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "dichotomised", "D0", "CRP", "to", "determine", "whether", "we", "could", "identify", "a", "practically", "useful", "cut-off", "to", "predict", "HGT", "." ] } ]
PMC11806106	Morphine and buprenorphine displayed the longest half-time of activation with ~7–8 s (Fig. 4C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Morphine", "and", "buprenorphine", "displayed", "the", "longest", "half-time", "of", "activation", "with", "~7–8", "s", "(", "Fig.", "4C", ")", "." ] } ]
PMC11641532	The siRNA sequences used in the study are listed in Table S2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "siRNA", "sequences", "used", "in", "the", "study", "are", "listed", "in", "Table", "S2", "." ] } ]
PMC7171147	Scale bar 200 µm.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", "200", "µm", "." ] } ]
PMC11574271	Pathologically, tissue invasion by bladder cancer cells, according to their depths of penetration, is categorized into two groups, including one that invades into the bladder muscle layers (muscle-invasive bladder cancer, MIBC) and another without the muscle penetration (non-muscle invasive bladder cancer, NMIBC) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathologically", ",", "tissue", "invasion", "by", "bladder", "cancer", "cells", ",", "according", "to", "their", "depths", "of", "penetration", ",", "is", "categorized", "into", "two", "groups", ",", "including", "one", "that", "invades", "into", "the", "bladder", "muscle", "layers", "(", "muscle-invasive", "bladder", "cancer", ",", "MIBC", ")", "and", "another", "without", "the", "muscle", "penetration", "(", "non-muscle", "invasive", "bladder", "cancer", ",", "NMIBC", ")", "." ] } ]
PMC11599565	Cisplatin resistance appears to enhance the expression of this enzyme as noticeable by ICC staining (ICC: Phalloidin in green, TH in red and DAPI in blue).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cisplatin", "resistance", "appears", "to", "enhance", "the", "expression", "of", "this", "enzyme", "as", "noticeable", "by", "ICC", "staining", "(", "ICC", ":", "Phalloidin", "in", "green", ",", "TH", "in", "red", "and", "DAPI", "in", "blue", ")", "." ] } ]
PMC4360730	Figure 4.Filtering search results using facets. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4.Filtering", "search", "results", "using", "facets", ".", "(" ] } ]
PMC6337547	The effects were superior in the salvianolic acid B high-dose group (60 mg·d·kg).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effects", "were", "superior", "in", "the", "salvianolic", "acid", "B", "high-dose", "group", "(", "60", "mg·d·kg", ")", "." ] } ]
PMC9429973	In CLL, serological responses were detectable in 21% of patients before vaccination and increased to 45% in the short-term and 71% in long-term observation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "CLL", ",", "serological", "responses", "were", "detectable", "in", "21", "%", "of", "patients", "before", "vaccination", "and", "increased", "to", "45", "%", "in", "the", "short-term", "and", "71", "%", "in", "long-term", "observation", "." ] } ]
PMC10976516	BOECs facilitate their use as CCs because they can be easily acquired from a peripheral blood draw, rapidly produced in cell culture to large numbers, and consistently cryopreserved without changing their genome or phenotype, which makes them very well suited for clinical applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BOECs", "facilitate", "their", "use", "as", "CCs", "because", "they", "can", "be", "easily", "acquired", "from", "a", "peripheral", "blood", "draw", ",", "rapidly", "produced", "in", "cell", "culture", "to", "large", "numbers", ",", "and", "consistently", "cryopreserved", "without", "changing", "their", "genome", "or", "phenotype", ",", "which", "makes", "them", "very", "well", "suited", "for", "clinical", "applications", "." ] } ]
PMC10203589	In addition, FGF18 is regulated by a variety of tumor autocrine or paracrine proteins ( Figure 2 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "FGF18", "is", "regulated", "by", "a", "variety", "of", "tumor", "autocrine", "or", "paracrine", "proteins", "(", "Figure", "2", ")", "." ] } ]
PMC9917080	As for the nanoselenium cassette, we have previously shown the effect of activation of reactive A2-type astrogliosis, which activates the defense mechanisms of brain cortex cells and promotes the survival of neuroglial cultures under conditions of ischemia .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "for", "the", "nanoselenium", "cassette", ",", "we", "have", "previously", "shown", "the", "effect", "of", "activation", "of", "reactive", "A2-type", "astrogliosis", ",", "which", "activates", "the", "defense", "mechanisms", "of", "brain", "cortex", "cells", "and", "promotes", "the", "survival", "of", "neuroglial", "cultures", "under", "conditions", "of", "ischemia", "." ] } ]
PMC9429973	Results: We tested a range of proteostatic targeting agents against primary, poor risk, AML patient samples and demonstrate a selective vulnerability of both AML blasts and LSCs to inhibition of CKS1-dependent protein degradation in vitro and in vivo using a small molecule inhibitor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "tested", "a", "range", "of", "proteostatic", "targeting", "agents", "against", "primary", ",", "poor", "risk", ",", "AML", "patient", "samples", "and", "demonstrate", "a", "selective", "vulnerability", "of", "both", "AML", "blasts", "and", "LSCs", "to", "inhibition", "of", "CKS1-dependent", "protein", "degradation", "in", "vitro", "and", "in", "vivo", "using", "a", "small", "molecule", "inhibitor", "." ] } ]
PMC8984067	However, there are quite a few disadvantages of these methods, such as systemic toxicity, radiation damage, low selectivity as well as drug resistance ; hence, developing safe and efficient treatment plans for malignant tumors is a major need.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "are", "quite", "a", "few", "disadvantages", "of", "these", "methods", ",", "such", "as", "systemic", "toxicity", ",", "radiation", "damage", ",", "low", "selectivity", "as", "well", "as", "drug", "resistance", ";", "hence", ",", "developing", "safe", "and", "efficient", "treatment", "plans", "for", "malignant", "tumors", "is", "a", "major", "need", "." ] } ]
PMC11129910	Our series included 13 patients, all females, who ranged in age from 44 to 92 years (median 76 years).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "series", "included", "13", "patients", ",", "all", "females", ",", "who", "ranged", "in", "age", "from", "44", "to", "92", "years", "(", "median", "76", "years", ")", "." ] } ]
PMC11345828	D. Tumor volume of control (gray), 26 dosed at 60 mg/kg q7d (orange), docetaxel dosed at 10 mg/kg q7d (teal), and 26 dosed at 60 mg/kg q7d + docetaxel dosed at 10 mg/kg q7d (beige).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D.", "Tumor", "volume", "of", "control", "(", "gray", ")", ",", "26", "dosed", "at", "60", "mg/kg", "q7d", "(", "orange", ")", ",", "docetaxel", "dosed", "at", "10", "mg/kg", "q7d", "(", "teal", ")", ",", "and", "26", "dosed", "at", "60", "mg/kg", "q7d", "+", "docetaxel", "dosed", "at", "10", "mg/kg", "q7d", "(", "beige", ")", "." ] } ]
PMC11441402	A compound that decreased this metabolic activity could be misinterpreted as being cytotoxic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "compound", "that", "decreased", "this", "metabolic", "activity", "could", "be", "misinterpreted", "as", "being", "cytotoxic", "." ] } ]
PMC9454852	REN cells were pre-treated with 50 µM 2-APB or 10 mM caffeine (inhibitors of the IICR) or with 10 µM U73122 (a potent phospholipase C (PLC) inhibitor) .	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "REN", "cells", "were", "pre-treated", "with", "50", "µM", "2-APB", "or", "10", "mM", "caffeine", "(", "inhibitors", "of", "the", "IICR", ")", "or", "with", "10", "µM", "U73122", "(", "a", "potent", "phospholipase", "C", "(", "PLC", ")", "inhibitor", ")", "." ] } ]
PMC11401350	Mice were sacrificed at humane endpoint or 200 days post-transplant (****p < 0.0001, Mantel-Cox test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mice", "were", "sacrificed", "at", "humane", "endpoint", "or", "200", "days", "post-transplant", "(", "", "", "", "", "p", "<", "0.0001", ",", "Mantel-Cox", "test", ")", "." ] } ]
PMC11746948	We consistently observed a dose-dependent and time-dependent reduction in GPX4 protein levels, while other ferroptosis-related proteins such as FSP1, SLC7A11, and ACSL4 remained unaffected (Fig. 3a, b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "consistently", "observed", "a", "dose-dependent", "and", "time-dependent", "reduction", "in", "GPX4", "protein", "levels", ",", "while", "other", "ferroptosis-related", "proteins", "such", "as", "FSP1", ",", "SLC7A11", ",", "and", "ACSL4", "remained", "unaffected", "(", "Fig.", "3a", ",", "b", ")", "." ] } ]
PMC11674146	In conclusion, our findings may provide new targets and perspectives for the treatment of lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "our", "findings", "may", "provide", "new", "targets", "and", "perspectives", "for", "the", "treatment", "of", "lymphoma", "." ] } ]
PMC7351993	Our protocol for cell sorting experiments is as follows.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "protocol", "for", "cell", "sorting", "experiments", "is", "as", "follows", "." ] } ]
PMC9100622	Cell authentication was performed by comparison with STR profiling from ATCC (A673, SK-N-MC) and DSMZ (TC71).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Cell", "authentication", "was", "performed", "by", "comparison", "with", "STR", "profiling", "from", "ATCC", "(", "A673", ",", "SK-N-MC", ")", "and", "DSMZ", "(", "TC71", ")", "." ] } ]
PMC9429973	Prior preclinical studies have shown that CD47 is critical to red blood cell (RBC) homeostasis, with CD47 deficiency decreasing RBC half-life.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "preclinical", "studies", "have", "shown", "that", "CD47", "is", "critical", "to", "red", "blood", "cell", "(", "RBC", ")", "homeostasis", ",", "with", "CD47", "deficiency", "decreasing", "RBC", "half-life", "." ] } ]
PMC9429973	Methods: We performed retrospective analysis of >50 patients at Heidelberg University hospital to identify risk factors of treatment failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "performed", "retrospective", "analysis", "of", ">", "50", "patients", "at", "Heidelberg", "University", "hospital", "to", "identify", "risk", "factors", "of", "treatment", "failure", "." ] } ]
PMC11738017	OPM2 or OPM2_BCMA target cell viability 48 hours after coculture with healthy donor PBMCs at an effector to target ratio of 10:1 with sBCMA at the indicated concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OPM2", "or", "OPM2_BCMA", "target", "cell", "viability", "48", "hours", "after", "coculture", "with", "healthy", "donor", "PBMCs", "at", "an", "effector", "to", "target", "ratio", "of", "10:1", "with", "sBCMA", "at", "the", "indicated", "concentrations", "." ] } ]
PMC9429973	The insufficiency of scientific knowledge related to the diagnosis, treatment, and management of multiple myeloma has real-world implications for patients and those who care for them.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "insufficiency", "of", "scientific", "knowledge", "related", "to", "the", "diagnosis", ",", "treatment", ",", "and", "management", "of", "multiple", "myeloma", "has", "real-world", "implications", "for", "patients", "and", "those", "who", "care", "for", "them", "." ] } ]
PMC9429973	Due to the risk of Graft-vs-Host Disease (GvHD) with DLI early after SCT, siremadlin will be given as priming monotherapy to prevent early relapse prior to starting siremadlin/DLI combination therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "the", "risk", "of", "Graft-vs-Host", "Disease", "(", "GvHD", ")", "with", "DLI", "early", "after", "SCT", ",", "siremadlin", "will", "be", "given", "as", "priming", "monotherapy", "to", "prevent", "early", "relapse", "prior", "to", "starting", "siremadlin/DLI", "combination", "therapy", "." ] } ]
PMC11244823	The gD1_180 fragment was predicted to fold in a similar manner as the full-length glycoprotein, but its structure was even stabilized in the presence of the C-terminal tail (Fig 9H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gD1_180", "fragment", "was", "predicted", "to", "fold", "in", "a", "similar", "manner", "as", "the", "full-length", "glycoprotein", ",", "but", "its", "structure", "was", "even", "stabilized", "in", "the", "presence", "of", "the", "C-terminal", "tail", "(", "Fig", "9H", ")", "." ] } ]
PMC5600151	Drugs and oligonucleotides can be either encapsulated in their internal cavities or bound to their surfaces through hydrophobic or electrostatic interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drugs", "and", "oligonucleotides", "can", "be", "either", "encapsulated", "in", "their", "internal", "cavities", "or", "bound", "to", "their", "surfaces", "through", "hydrophobic", "or", "electrostatic", "interactions", "." ] } ]
PMC4360730	By doing so, we continue to maintain a consistent representation of experimental variables and introduce new ways of searching and organizing the data (8, 9).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "doing", "so", ",", "we", "continue", "to", "maintain", "a", "consistent", "representation", "of", "experimental", "variables", "and", "introduce", "new", "ways", "of", "searching", "and", "organizing", "the", "data", "(", "8", ",", "9", ")", "." ] } ]
PMC11704135	Regarding anti-tumor effectiveness, compound 10 has demonstrated notable potency against the MCF-7 cell line, demonstrating moderate anti-tumor activity relative to cisplatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regarding", "anti-tumor", "effectiveness", ",", "compound", "10", "has", "demonstrated", "notable", "potency", "against", "the", "MCF-7", "cell", "line", ",", "demonstrating", "moderate", "anti-tumor", "activity", "relative", "to", "cisplatin", "." ] } ]
PMC11412721	We used lipofectamine 2000 to transfect Trp53 MEFs with 2 μg of either luciferase expression vector, 2 μg of an expression vector for p53, p53 or the DNA-binding mutant p53, and 30 ng of a renilla luciferase expression plasmid (pGL4.73, Promega) for normalization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "lipofectamine", "2000", "to", "transfect", "Trp53", "MEFs", "with", "2", "μg", "of", "either", "luciferase", "expression", "vector", ",", "2", "μg", "of", "an", "expression", "vector", "for", "p53", ",", "p53", "or", "the", "DNA-binding", "mutant", "p53", ",", "and", "30", "ng", "of", "a", "renilla", "luciferase", "expression", "plasmid", "(", "pGL4.73", ",", "Promega", ")", "for", "normalization", "." ] } ]
PMC11655536	The results showed that the tumor volume of the HA 10 mg group was significantly decreased, but a minimal change of tumor volume was observed in the 5 mg group (Fig. 5B, C), indicating efficient inhibition of MM tumor with HA at 10 mg/kg/day dose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "that", "the", "tumor", "volume", "of", "the", "HA", "10", "mg", "group", "was", "significantly", "decreased", ",", "but", "a", "minimal", "change", "of", "tumor", "volume", "was", "observed", "in", "the", "5", "mg", "group", "(", "Fig.", "5B", ",", "C", ")", ",", "indicating", "efficient", "inhibition", "of", "MM", "tumor", "with", "HA", "at", "10", "mg/kg/day", "dose", "." ] } ]
PMC7823217	On the other hand, Type II neoplastic cells are high-grade and fast developing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "Type", "II", "neoplastic", "cells", "are", "high-grade", "and", "fast", "developing", "." ] } ]
PMC10999934	Wenwen Lai: Writing – original draft, Validation, Software, Formal analysis, Conceptualization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Wenwen", "Lai", ":", "Writing", "–", "original", "draft", ",", "Validation", ",", "Software", ",", "Formal", "analysis", ",", "Conceptualization", "." ] } ]
PMC11693599	The expression levels of CD109 on the cell surface greatly increased in A2780-SP and SKOV3-SP cells compared to their 2D-cultured parental cells (Fig. 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "levels", "of", "CD109", "on", "the", "cell", "surface", "greatly", "increased", "in", "A2780-SP", "and", "SKOV3-SP", "cells", "compared", "to", "their", "2D-cultured", "parental", "cells", "(", "Fig.", "1C", ")", "." ] } ]
PMC11085211	The most active ones were phytochemically investigated compared to the inactive or weakly active ones, which were eluted immediately before or after.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "active", "ones", "were", "phytochemically", "investigated", "compared", "to", "the", "inactive", "or", "weakly", "active", "ones", ",", "which", "were", "eluted", "immediately", "before", "or", "after", "." ] } ]
PMC11467964	The risk score calculation formula is as follows: Risk score = Σ (Expi * coefi).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "risk", "score", "calculation", "formula", "is", "as", "follows", ":", "Risk", "score", "=", "Σ", "(", "Expi", "*", "coefi", ")", "." ] } ]
PMC11605551	Further studies are necessary to examine the functional role of these genes in invasion and leptomeningeal metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "are", "necessary", "to", "examine", "the", "functional", "role", "of", "these", "genes", "in", "invasion", "and", "leptomeningeal", "metastasis", "." ] } ]
PMC7961460	Although the lack of a well-documented literature about the functions of this protein (especially in breast cancer) some papers described c10orf118 as a golgin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "lack", "of", "a", "well-documented", "literature", "about", "the", "functions", "of", "this", "protein", "(", "especially", "in", "breast", "cancer", ")", "some", "papers", "described", "c10orf118", "as", "a", "golgin", "." ] } ]
PMC11718109	A Co-expression of VGLUT2-GFP (green), mCherry-synapsin (magenta), synaptophysin (untagged) and VMAT2-FLAG (cyan) in COS7 cells show preference of VGLUT2-GFP fluorescence signals in the synaptophysin-synapsin vesicle clusters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Co-expression", "of", "VGLUT2-GFP", "(", "green", ")", ",", "mCherry-synapsin", "(", "magenta", ")", ",", "synaptophysin", "(", "untagged", ")", "and", "VMAT2-FLAG", "(", "cyan", ")", "in", "COS7", "cells", "show", "preference", "of", "VGLUT2-GFP", "fluorescence", "signals", "in", "the", "synaptophysin-synapsin", "vesicle", "clusters", "." ] } ]
PMC9429973	3D confocal microscopy and histological analysis of recellularized model showed the generation of MSC niches which fostered growth and adaptation of lymphoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3D", "confocal", "microscopy", "and", "histological", "analysis", "of", "recellularized", "model", "showed", "the", "generation", "of", "MSC", "niches", "which", "fostered", "growth", "and", "adaptation", "of", "lymphoma", "cells", "." ] } ]
PMC10329074	For the Transwell assays, the cell suspension was prepared at a final density of 6 × 10 cells/well with serum-free medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "Transwell", "assays", ",", "the", "cell", "suspension", "was", "prepared", "at", "a", "final", "density", "of", "6", "×", "10", "cells/well", "with", "serum-free", "medium", "." ] } ]
PMC11704834	Dysfunction of epigenetic regulators in the form of transcriptional coactivators and corepressors may result in altered DNA and histone proteins through recruitment of chromatin remodelling enzymes to target gene promoter and in transcriptional profiles that render cancer cells resistant to targeted therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dysfunction", "of", "epigenetic", "regulators", "in", "the", "form", "of", "transcriptional", "coactivators", "and", "corepressors", "may", "result", "in", "altered", "DNA", "and", "histone", "proteins", "through", "recruitment", "of", "chromatin", "remodelling", "enzymes", "to", "target", "gene", "promoter", "and", "in", "transcriptional", "profiles", "that", "render", "cancer", "cells", "resistant", "to", "targeted", "therapy", "." ] } ]
PMC11767582	HRMS (ESI/Q-TOF): m/z [M+H] calcd.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HRMS", "(", "ESI/Q-TOF", "):", "m/z", "[", "M+H", "]", "calcd", "." ] } ]
PMC8526701	Scale bar: 100 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "100", "μm", "." ] } ]

PMC11637820

The Indian subcontinent has various ethnic and cultural groups and experiences a wide range of climatic conditions from arid deserts to humid tropical regions, making it exceptionally climatically diverse, while antimicrobial resistance arises from the overuse of antibiotics .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Indian", "subcontinent", "has", "various", "ethnic", "and", "cultural", "groups", "and", "experiences", "a", "wide", "range", "of", "climatic", "conditions", "from", "arid", "deserts", "to", "humid", "tropical", "regions", ",", "making", "it", "exceptionally", "climatically", "diverse", ",", "while", "antimicrobial", "resistance", "arises", "from", "the", "overuse", "of", "antibiotics", "." ] } ]

PMC11551844

Each cell line was incubated in Falcon T-25 vented tissue flasks (Corning Inc., NY) in DMEM supplemented with fetal bovine serum (10%) and penicillin/streptomycin (100 U mL) at 37 °C in air with 5% CO2.

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PMC11502066

GPR30 is a membranous estrogen receptor that functions independently of the classical nuclear estrogen receptors, ERα and ERβ, and mediates both rapid non-genomic signaling via multiple intracellular pathways as well as transcriptional events .

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PMC11285179

The separated cells were cultured in F12K medium (Gibco, LifeTech, USA) containing 10% fetal bovine serum (Gibco, Life Tech, USA) with 100 U/mL penicillin and 100 μg/mL streptomycin.

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PMC11745823

Additionally, it promotes tumour proliferation by inhibiting apoptosis and accelerating cell cycle progression.

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PMC11711871

Under NSD conditions, the relaxation induced by DEA/NO was slightly but significantly increased in GR rats compared to wild-type rats (Fig. 6E) with a greater AUC (Fig. 6F), while under HSD conditions, no difference was found between the two genotypes.

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PMC11322866

Recent studies suggested that RRM2 may play an important role as a bridge between senescence and cancer .

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PMC11472569

Research by Hekmatirad et al. showed that GW4869 effectively prevents the efflux of PEGylated liposomal doxorubicin (PLD) and increases U937 cell sensitivity to PLD’s cytotoxic effects.

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PMC10297204

There was no significant difference in latency between the control group (1.45 ± 0.11 ms) and the 30E group (1.40 ± 0.08 ms; p = 0.98; Figure 6A).

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PMC5810978

We did not observe significant RNA level increases for HuSaV and BoNoV under our test conditions.

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PMC7987994

Significance codes according to p value: 0 ‘***’0.001 ‘**’0.01 ‘*’0.05 (two-sample t-test).Figure 4Relative metabolic activity of L929 cells (resazurin assay) after 24 h incubation with extracts of Mg_HF_SPS.

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PMC11271278

Expression levels were normalized to cells treated with a non-targeting sgRNA (NT1).

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PMC9429973

Sixty percent of patients (n=53) had an intermediate-high or high IPI score-risk and 40% (n=35) showed low IPI score-risk.

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PMC9509578

Antibody-functionalized metal nanosystems can actively target and recognize multidrug-resistant tumor cells.

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PMC11599565

OVCAR-3 cells exposed to cisplatin for 14 days revealed profound changes in the cell morphology towards “neuronal” phenotype.

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PMC9429973

Socioeconomic factors including insurance status, level of education and median household income per zip code, and facility type appear to be associated with outcomes.

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PMC5673060

The low percentage of phosphorylation changes observed in our study may be due to a number of factors.

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PMC11363012

Targeted and untargeted mass spectrometry data are then processed to obtain quantitative and qualitative information (step 5).

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PMC9429973

Our findings help further define therapy-associated ALL as a distinct entity, but also highlight the need for a better molecular understanding of its specific disease evolution.

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PMC11098378

P. syringae is a plant pathogen that has been an important model for understanding plant immunity to bacterial infection.

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PMC11365983

Immunofluorescent staining demonstrated ~ 1.9-fold reductions in both total PDGFRα, and the level of the active autophosphorylated form, in E14.5 Foxc1 embryos compared to wild type littermates (PDGFRα: Foxc1 0.55, WT 1.0, P = 2.6 × 10; pY754-PDGFRα: Foxc1 0.54, WT 1.0, P = 0.048; Fig. 8A–G).

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PMC11222184

The protein expression (A) changes in HSPs (HSP27, HSP70, HSP90) and the abundance HSPs in SH-SY5Y (B). (*

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PMC11583690

The solution was stirred at 80 °C, at 1,500 revolutions per minute (rpm).

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PMC11509224

A total of 13 diterpenes were obtained from Dysidea sponges.

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PMC8623816

The RNA quality and integrity were determined by Agilent 2100 Bioanalyzer (Agilent 2100) and 1% agarose gel electrophoresis, respectively.

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PMC9621239

Sn at each amino acid site in genotype-B clones. (

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PMC9587298

The incubation of caffeic acid with MGO resulted in two compounds corresponding to negative ions at m/z 251 and 323 that were attributed to the formation of mono- and di-MGO adducts of caffeic acid.

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PMC9599726

Contingency tables and Freeman–Halton extensions of Fisher’s test were performed to study the relationship between TFRC expression and non-continuous variables, such as tumor location, sex, mitotic figures, histological type, risk classification, YAP-ir, YAP activation, and KIT-ir.

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PMC10899471

MiR-939-3p mimics or inhibitors, and negative controls were purchased from Tsingke Biotechnology, which were listed in Supplementary Table S3 .

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PMC7154001

These studies involved a total of 57 (57.0%) conventional anticancer drugs/synthetic anticancer candidates,6,13–58 22 (22.0%) studies for small-molecules targeted therapy,4,5,59–70 and 21 (21.0%) studies for herb-derived compounds with anticancer activities2,3,7,9,71–83 (Tables 1–3).

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PMC8193046

The corresponding IC50 values of compounds 16–25 can be found in Table 1.

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PMC11555465

Bladder cancer is a prevalent urological malignancy with a poor prognosis in the advanced/metastatic stage.

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PMC9429973

The adherence to treatment it is significantly higher in patients older than 45 years.

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PMC10213199

The gene showed the highest expression during the G0/G1 phase, whereas it was downregulated after the G1 phase .

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PMC6643347

Only two companies (one in the United States and one in Russia) have so far succeeded in developing humic substance-based drugs and in completing all the requisite preclinical and clinical trials of their safety and efficacy .

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PMC11574271

Actin-Tracker Red-555 and DAPI were utilized for staining the cytoskeleton and nucleus, respectively, with representative images displayed in Fig. (G) and (H).

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PMC11267830

Moreover, DCAF15 cannot fully predict the efficacy of the antitumor action of indisulam.

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PMC11347429

Principal component analysis of transcriptome expression.

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PMC11538390

The prevalence was estimated by dividing the number of CP cases in each region by the total number of individuals in that region.

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PMC9429973

The BCR-ABL transcript was of the p190 type in 2 cases and p210 in 2 cases, while the molecular study was not done in the remaining case.

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PMC11538390

NS represents non-significant (P = 0.1212).

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PMC11726848

This cell type is a suitable model because radiotherapy has been widely used for the treatment of tumors of epidermal origin .

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PMC11789597

All viability assays were determined in triplicate and replicated in three independent experiments.

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PMC10813895

It discusses the lineage-specific expression of ELF5, its regulatory mechanisms, and its potential as a biomarker for breast-specific biological age and cancer risk.

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PMC11609529

Using YM-positive ES-2 cancer cells as a model, our knockdown and KO studies established that the YM fusion is critical for sustaining cell growth and survival in YM-positive cancer cells.

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PMC2944824

Decreases in potential indicate that the mitochondrial membrane has become compromised and can begin to release cytochrome C. The decrease in potential was significantly greater in cultures from Hr knockout mice treated with thapsigargin and staurosporine.

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PMC9118379

PepS-A for SG-A searching), 11–30 a.a. (

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PMC11551844

Zeta potential values indicated that AuNPs-JC-2 was more stable than AuNPs-JDE, AuNPs-JDH and AuNPs-ansellone.

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PMC11746948

This suggests that contribution of 2-BP to enhancing ferroptosis susceptibility is unlikely to be through a broad regulation of lipid composition.

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PMC11139449

Homology-Independent Targeted Integration (HITI) combined with CRISPR enhances transgene integration rates in divid-ing and non-dividing CHO cells ( 13 ).

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PMC11342785

In contrast, N-terminal TPPP fragments showed no light-dependent clustering onto MTs (Figs. 3B and S3B).

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PMC11704834

Briefly, the lentiviral products were produced using the second-generation system by transfecting the 293T cell line with 1 µg of lentiviral plasmid, 1.2 µg of packaging plasmid, and 6.6 µl of Lipofectamine 2000 reagent (Invitrogen; Thermo Fisher Scientific, Inc.) in 250 µl OPTI-MEM (Invitrogen; Thermo Fisher Scientific, Inc.) and incubated at 37˚C humidified incubator with 5% CO2.

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PMC5673955

Membranes were washed in Tris‐buffered saline, pH 7.6 with 0.1% Tween‐20 (Invitrogen) and incubated with secondary antibodies conjugated with horseradish peroxidase (Cell Signaling, Danvers, MA).

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PMC9429973

We then dichotomised D0 CRP to determine whether we could identify a practically useful cut-off to predict HGT.

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PMC11806106

Morphine and buprenorphine displayed the longest half-time of activation with ~7–8 s (Fig. 4C).

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PMC11641532

The siRNA sequences used in the study are listed in Table S2.

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PMC7171147

Scale bar 200 µm.

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PMC11574271

Pathologically, tissue invasion by bladder cancer cells, according to their depths of penetration, is categorized into two groups, including one that invades into the bladder muscle layers (muscle-invasive bladder cancer, MIBC) and another without the muscle penetration (non-muscle invasive bladder cancer, NMIBC) .

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PMC11599565

Cisplatin resistance appears to enhance the expression of this enzyme as noticeable by ICC staining (ICC: Phalloidin in green, TH in red and DAPI in blue).

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PMC4360730

Figure 4.Filtering search results using facets. (

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PMC6337547

The effects were superior in the salvianolic acid B high-dose group (60 mg·d·kg).

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PMC9429973

In CLL, serological responses were detectable in 21% of patients before vaccination and increased to 45% in the short-term and 71% in long-term observation.

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PMC10976516

BOECs facilitate their use as CCs because they can be easily acquired from a peripheral blood draw, rapidly produced in cell culture to large numbers, and consistently cryopreserved without changing their genome or phenotype, which makes them very well suited for clinical applications.

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PMC10203589

In addition, FGF18 is regulated by a variety of tumor autocrine or paracrine proteins ( Figure 2 ).

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PMC9917080

As for the nanoselenium cassette, we have previously shown the effect of activation of reactive A2-type astrogliosis, which activates the defense mechanisms of brain cortex cells and promotes the survival of neuroglial cultures under conditions of ischemia .

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PMC9429973

Results: We tested a range of proteostatic targeting agents against primary, poor risk, AML patient samples and demonstrate a selective vulnerability of both AML blasts and LSCs to inhibition of CKS1-dependent protein degradation in vitro and in vivo using a small molecule inhibitor.

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PMC8984067

However, there are quite a few disadvantages of these methods, such as systemic toxicity, radiation damage, low selectivity as well as drug resistance ; hence, developing safe and efficient treatment plans for malignant tumors is a major need.

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PMC11129910

Our series included 13 patients, all females, who ranged in age from 44 to 92 years (median 76 years).

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PMC11345828

D. Tumor volume of control (gray), 26 dosed at 60 mg/kg q7d (orange), docetaxel dosed at 10 mg/kg q7d (teal), and 26 dosed at 60 mg/kg q7d + docetaxel dosed at 10 mg/kg q7d (beige).

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PMC11441402

A compound that decreased this metabolic activity could be misinterpreted as being cytotoxic.

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PMC9454852

REN cells were pre-treated with 50 µM 2-APB or 10 mM caffeine (inhibitors of the IICR) or with 10 µM U73122 (a potent phospholipase C (PLC) inhibitor) .

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PMC11401350

Mice were sacrificed at humane endpoint or 200 days post-transplant (****p < 0.0001, Mantel-Cox test).

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PMC11746948

We consistently observed a dose-dependent and time-dependent reduction in GPX4 protein levels, while other ferroptosis-related proteins such as FSP1, SLC7A11, and ACSL4 remained unaffected (Fig. 3a, b).

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PMC11674146

In conclusion, our findings may provide new targets and perspectives for the treatment of lymphoma.

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PMC7351993

Our protocol for cell sorting experiments is as follows.

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PMC9100622

Cell authentication was performed by comparison with STR profiling from ATCC (A673, SK-N-MC) and DSMZ (TC71).

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PMC9429973

Prior preclinical studies have shown that CD47 is critical to red blood cell (RBC) homeostasis, with CD47 deficiency decreasing RBC half-life.

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PMC9429973

Methods: We performed retrospective analysis of >50 patients at Heidelberg University hospital to identify risk factors of treatment failure.

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PMC11738017

OPM2 or OPM2_BCMA target cell viability 48 hours after coculture with healthy donor PBMCs at an effector to target ratio of 10:1 with sBCMA at the indicated concentrations.

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PMC9429973

The insufficiency of scientific knowledge related to the diagnosis, treatment, and management of multiple myeloma has real-world implications for patients and those who care for them.

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PMC9429973

Due to the risk of Graft-vs-Host Disease (GvHD) with DLI early after SCT, siremadlin will be given as priming monotherapy to prevent early relapse prior to starting siremadlin/DLI combination therapy.

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PMC11244823

The gD1_180 fragment was predicted to fold in a similar manner as the full-length glycoprotein, but its structure was even stabilized in the presence of the C-terminal tail (Fig 9H).

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PMC5600151

Drugs and oligonucleotides can be either encapsulated in their internal cavities or bound to their surfaces through hydrophobic or electrostatic interactions.

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PMC4360730

By doing so, we continue to maintain a consistent representation of experimental variables and introduce new ways of searching and organizing the data (8, 9).

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PMC11704135

Regarding anti-tumor effectiveness, compound 10 has demonstrated notable potency against the MCF-7 cell line, demonstrating moderate anti-tumor activity relative to cisplatin.

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PMC11412721

We used lipofectamine 2000 to transfect Trp53 MEFs with 2 μg of either luciferase expression vector, 2 μg of an expression vector for p53, p53 or the DNA-binding mutant p53, and 30 ng of a renilla luciferase expression plasmid (pGL4.73, Promega) for normalization.

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PMC11655536

The results showed that the tumor volume of the HA 10 mg group was significantly decreased, but a minimal change of tumor volume was observed in the 5 mg group (Fig. 5B, C), indicating efficient inhibition of MM tumor with HA at 10 mg/kg/day dose.

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PMC7823217

On the other hand, Type II neoplastic cells are high-grade and fast developing.

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PMC10999934

Wenwen Lai: Writing – original draft, Validation, Software, Formal analysis, Conceptualization.

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PMC11693599

The expression levels of CD109 on the cell surface greatly increased in A2780-SP and SKOV3-SP cells compared to their 2D-cultured parental cells (Fig. 1C).

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PMC11085211

The most active ones were phytochemically investigated compared to the inactive or weakly active ones, which were eluted immediately before or after.

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PMC11467964

The risk score calculation formula is as follows: Risk score = Σ (Expi * coefi).

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PMC11605551

Further studies are necessary to examine the functional role of these genes in invasion and leptomeningeal metastasis.

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PMC7961460

Although the lack of a well-documented literature about the functions of this protein (especially in breast cancer) some papers described c10orf118 as a golgin.

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PMC11718109

A Co-expression of VGLUT2-GFP (green), mCherry-synapsin (magenta), synaptophysin (untagged) and VMAT2-FLAG (cyan) in COS7 cells show preference of VGLUT2-GFP fluorescence signals in the synaptophysin-synapsin vesicle clusters.

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PMC9429973

3D confocal microscopy and histological analysis of recellularized model showed the generation of MSC niches which fostered growth and adaptation of lymphoma cells.

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PMC10329074

For the Transwell assays, the cell suspension was prepared at a final density of 6 × 10 cells/well with serum-free medium.

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PMC11704834

Dysfunction of epigenetic regulators in the form of transcriptional coactivators and corepressors may result in altered DNA and histone proteins through recruitment of chromatin remodelling enzymes to target gene promoter and in transcriptional profiles that render cancer cells resistant to targeted therapy.

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PMC11767582

HRMS (ESI/Q-TOF): m/z [M+H] calcd.

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PMC8526701

Scale bar: 100 μm.

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