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PMC10840195
In our study, we first constructed sunitinib-resistant RCC strains and Twist-overexpressing cells and then studied the changes in biological function and mechanisms by determining the protein expression levels of key nodes of the Wnt/β-catenin signalling pathway.
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PMC9429973
Hybridization capture allows the comparison of the number of reads per position between samples to identify structural variants as PTDs.
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PMC11731614
KDEVs analyzed with dynamic light scattering had a size range of 59.2 ± 14.5 nm (mean ± StDev).
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PMC11267036
Fig. 2C revealed that the mRNA expression levels of RIG-I in MM cell lines (U266, RPMI-8226, NCI-H929) were notably lower than those in nPCs, especially in U266 cells (p < 0.05).
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PMC11615828
The local and random movement of TGN38‐mNeon‐FKBP vesicles caused by MT disassembly was further suppressed by trapping them on LifeAct‐FRB‐labeled actin filaments (Figure S11 and Video S11, Supporting Information).
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PMC9100622
After release of thymidine, we observed a delay of around 2 h in the progression into the S-phase of cells treated with Atorvastatin (Figure S4C).
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PMC11389534
Investigating the influence of UFL1 on ovarian hormone levels is essential for a comprehensive understanding of female reproductive health.
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PMC5963610
Several anti-EGFR therapeutic approaches have demonstrated antitumor effect [4–6], however; clinic benefits in terms of overall survival has been limited.
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PMC11772585
D, E The expression of METTL1 in HaCaT keratinocytes and cSCC cell lines (HSC-1 and A431) were detected by western blot and qRT-PCR, respectively.
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PMC6684588
Data represent 200 fibers per muscle (n = 10 mice). (
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PMC9503669
These interactions account for many Nef activities, including downregulation of cell-surface major histocompatibility complexes (MHC-I/II) and viral receptors (CD4/CXCR4/CCR5) , counteracting host cell restriction factors (e.g., SERINC proteins) , actin cytoskeleton remodeling , and stimulation of host cell signaling pathways (e.g., Tec- and Src-family kinases, ).
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PMC11742231
Similarly, in vitro cell line models , while useful for screening drug sensitivity, fail to capture the complex biological characteristics of tumors in patients, limiting their clinical relevance.
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PMC11496491
Red dots indicate up-regulated genes, green dots indicate down-regulated genes, and black dots indicate non-significant differentially expressed genes. (
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PMC10335954
However, the results from western blotting in our study showed that IL-6 expression increased when TRIP13 was knocked down, indicating that other pathways may affect the expression of IL-6.
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PMC11291490
When DEFs reached approximately 90% confluence, they were individually transfected with the following plasmids, pVAX1, pVAX-prM-E, and pVAX-prM-E-dusCD40L.
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PMC10218459
One of the observed effects of CPP treatments on cancer cells is that some cells die immediately as a result of the CPP application.
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PMC11628309
An alternative cellular model is the neuroblastoma BE (2)-M17 which exhibits a high basal expression of numerous dopaminergic markers such as tyrosine hydroxylase (TH), vesicular monoamine transporter 2 (VMAT2), and dopamine transporter (DAT).
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PMC11047729
In vivo studies showed decreased levels of this secosteroid circulating in the bloodstream.
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PMC11740508
Poly (ADP-Ribose) polymerase inhibitors are approved for treatment of tumors with BRCA1/2 and other homologous recombination repair (HRR) mutations.
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PMC11012313
LMP2A has historically been considered purely a BCR mimic due to the activation of Lyn and Syk through its ITAM motifs that are also found in the signaling molecules Igα and Igβ associated with surface immunoglobulin .
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PMC11531744
Risk curves showing the distribution of survival status of TCGA OC patients.
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PMC8427838
A Immunohistochemistry staining of human kidney tissues with control antibody or with anti-TMIGD1 antibody.
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PMC11656380
Consequently, these results suggest that Tat-Ram13 is a tumor-selective, nonapoptotic cell death-inducing agent for treating refractory leukemia and lymphomas with apoptosis resistance.
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PMC11792766
The involvement of food simulants at the concentrations specified in Table 3 did not present any background effects or interference with the assay's function, neither in the presence nor absence of the microsomes, as shown in Figure 8a,b. Effect of food simulants on the bacterial reverse mutation assay in the absence (a) and presence (b) of rat liver S9 mix.
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PMC11655536
The tumor volume in the experimental group was significantly smaller than that in the control group, and the expression of the proliferation marker Ki67 was also significantly reduced compared to the control group.
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PMC9429973
A patient was defined as relapsed/refractory (R/R) if they had commenced a drug which was in a different therapeutic category, or if they re-started the same regimen after a gap of more than 180 days.
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PMC11541241
Moreover, MoGAP1 was also involved in cell wall stress and carbon source stress.
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PMC11711871
In humans, glucocorticoid resistance is attributed to mutations in the glucocorticoid receptor (GR).
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PMC9429973
Fourteen patients received the murinized CAR-T cells at a median dose of 2.18×10/kg (1-3×10/kg) CAR19 and 1.75×10/kg (1-3×10/kg) CAR22, while 12 patients received the does of the humanized CAR-T cells consisting of 2×10kg CAR19 and 5×10/kg CAR22.
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PMC9429973
Despite literature indicating that patient QoL and cost of tx should both be key considerations for physicians when choosing FL tx, our study highlights these are less commonly reported attributes for treatment selection.
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PMC11740907
Beeswax is a substance that lacks polarity, while Tween 80 is a surfactant that has polarity.
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PMC10440586
The patients were divided into two groups based on the CD99 expression level of the first-onset sample.
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PMC10938336
These networks were merged to create a comprehensive compound–target–disease network.
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PMC6442998
GIST882 cells present a phenotype close to the ICC phenotype (KIT+, PDE3A+, αSMA-) while the GIST48 cells phenotype may be closer to the phenotype of ICC/SMC mesenchymal precursors (Kit+, PDE3A low, αSMA+).
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PMC11291697
To date, disruption of GTDC1, as a consequence of a de novo chromosome translocation t(2;8), was reported in only one individual with developmental and speech/language delay .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "date", ",", "disruption", "of", "GTDC1", ",", "as", "a", "consequence", "of", "a", "de", "novo", "chromosome", "translocation", "t(2;8", ")", ",", "was", "reported", "in", "only", "one", "individual", "with", "developmental", "and", "speech/language", "delay", "." ] } ]
PMC10094992
The immunostained MCSs were counterstained with Diamidino-2-phenylindole (DAPI), rinsed with PBS and mounted on slides using fluorescent aqueous mounting medium (Agilent Dako, Santa Clara, CA, USA).
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PMC10114490
RT-qPCR expression was determined by the 2 using PBGD gene (HMBS) as normalizer.
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PMC8708099
After 24 h, the medium was removed and replaced with the medium with tested compounds.
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PMC11335267
After this, vehicle (0.9% NaCl) or recombinant mouse leptin (3 µg/g) (Peprotech catalogue nº 450−31) was injected i.p.
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PMC11695623
Through the data of TCGA, the correlation between DCUN1D5 and other mRNA in LUAD is analyzed.
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PMC11777207
We also observed less surface-associated PD-L1 on DCs after PD-L1 43H12 antibody treatment, likely due to the steric hindrance of these antibodies (fig. S9).
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PMC11739504
Taken together, these findings highlight the novel role of Kat2b in regulating primary cilium function and its pathological effects on the kidney.
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PMC9429973
Among the 35 pts with ND Ph+ ALL, 12 were in CR at enrollment (including 2 pts in CMR).
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PMC10178190
Manhattan distance, which is the absolute sum of log 2 of fold changes and -log 10 of p value, was determined for high signal dots and is shown in a heatmap.
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PMC11644761
Their capacity to survive in culture for extended periods enables prolonged experiments with high reproducibility, thereby minimizing experimental variability.
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PMC5916734
Genomic DNA was isolated using a Wizard SV Genomic DNA Purification System kit (Promega, USA).
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PMC11300639
m 786-O and A498 cells were harvested for immunoprecipitation by using the CDK4 or RNF26 antibodies.
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PMC10728200
The relative GSH/GSSG ratios were assayed.
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PMC5963610
Each point represents mean±SD per animals/group.
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PMC9424261
Interestingly, we found that CA has almost no effect on normal liver cells at low concentrations.
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PMC8358006
calculated from night replicates. ***
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "calculated", "from", "night", "replicates", ".", "*", "*", "*" ] } ]
PMC9429973
The plasma concentration of CCL17/TARC was elevated in both LIM and ADV cHL compared to controls (median 5256 (p=0.0002) and 9165 (p<0.0001) vs. 61.03 pg/mL, respectively) (Figure 1).
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PMC10040136
The VEGF mRNA forward primer was TTGCCTTGCTGCTCTACCTCCA, and the VEGF mRNA reverse primer was GATGGCAGTAGCTGCGCTGATA.
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PMC10748106
All the iridoids fell within the applicability domain of the model, suggesting the application of the model for predicting the cytotoxic activity of new iridoids with remarkably high molecular and structural similarity.
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PMC11747949
Interestingly, we observed two populations having either low or high expression of CD44.
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PMC9429973
Treatment for symptomatic and/or predominantly haemolytic PNH patients is associated with an improvement in survival and quality of life (QoL).
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PMC11621493
The “count” (dot size) reflects the total number of genes in the gene set and the color coding highlights the FDR-adjusted P value of the gene set. (
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PMC11248911
Cell pellets were fixed with 70% ethanol on ice for 15 min and collected again.
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PMC11453018
D Quantification of intensity of Annexin V staining.
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PMC11435360
After cysteine is converted to mercaptopyruvate, the enzyme 3-MST, localized in the mitochondria, further breaks the substrate down into H2S and pyruvate .
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PMC10940855
To determine the effect of silencing EFNB2 reverse signaling on multiple myeloma growth in vivo, we compared the repopulation of U266 multiple myeloma cells following transplantation into NSG mice.
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PMC11755624
lncRNAs play important roles in skin functionality, such as keratinocyte differentiation .
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PMC10847511
Association between HR-related gene alterations with locus-specific LOH and HRD score.
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PMC9429973
Aims: To evaluate the efficacy, treatment administration satisfaction and safety of SC ravulizumab through the first 1 year (day 351) of treatment in adult patients with PNH previously treated with eculizumab.
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PMC11188874
Peptides were loaded directly and eluted using 50/50 acetonitrile/water (0.1% trifluoroacetic acid [TFA]).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peptides", "were", "loaded", "directly", "and", "eluted", "using", "50/50", "acetonitrile/water", "(", "0.1", "%", "trifluoroacetic", "acid", "[", "TFA", "]", ")", "." ] } ]
PMC5417661
The leukemia cell line CCRF-CEM (RPMI 1640), the ovarian carcinoma cell lines A2780 and A2780/Adr (RPMI 1640), the pancreatic adenocarcinoma cell line BXPC-3 (RPMI 1640), the lymphoma cell line U-937 (RPMI 1640), the myeloma cell line RPMI 8226 (RPMI 1640) and the colon carcinoma cell lines HT29 (McCoy’s medium) and HCT116 (McCoy’s medium) were purchased from European Collection of Cell Cultures (ECACC, Salisbury, UK).
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PMC10968586
OLE and HT are also found in the fruit of Olea europaea L. and in olive oil; thus, they are easily ingested as part of a routine diet, but they can also be obtained from other sources, e.g., olive mill wastewater .
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PMC11713679
in alleviating these changes.
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PMC11768281
However, the complexity of immune evasion strategies employed by Plasmodium necessitates further research into enhancing T-cell activation and sustaining their efficacy .
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PMC11787381
Effects of formulated bambuterol on the total distance swum in the Morris water maze (B), on swim velocity (C), time spent around the supposed location of the platform (ring area) during the retention phase (D) and the latency to reach the ring area (E) [control (white), bambuterol (green)].
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PMC11732523
Early administration of antiviral therapy during the initial stages of infection may benefit GS patients, and immunoglobulin replacement therapy could serve as the cornerstone of infection prevention and management in this population .
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PMC9429973
Summary/Conclusion: Our study concludes to a worsening of MPN symptoms when associated to comorbidities.
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PMC11670954
Fourth, while we robustly demonstrated that BA mitigates barrier impairment in epithelial cells following LPS injury through the up-regulation of ZO-1 and Occludin, elucidating the ability of BA to significantly increase cell viability is crucial.
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PMC7762347
This is in line with the previously reported MCLR induced lesions.
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PMC10291556
A thorough inspection of the data in Tables 1 and 3 revealed the correlation between log P values, amount of intracellular Pt, and antiproliferative activity (IC50).
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PMC10898159
KIT D816V and KIT N882 both are situated closely on the KIT receptor activation loop activating the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, but in KIT N822K it is also the downstream activation of the MAPK .
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PMC10654497
Ferroptosis is a distinct form of iron-dependent programmed cell death that is characterized by the buildup of lipid peroxides and intracellular reactive oxygen species.
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PMC11742670
These descriptors could pertain to structural attributes, chemical properties, Morgan fingerprint that represent molecular structure in binary format for similarity analysis, or any other physicochemical properties that play a pivotal role in the drug’s efficacy.
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PMC9581083
Many Chinese herbal formulas have emerged from these theoretical foundations.
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PMC11534377
Dark-field microscopy was performed using an Olympus B × 43 microscope (Olympus, Tokyo, Japan) equipped with a CytoViva Enhanced Dark-Field Condenser (Cytoviva, USA), a Dual Mode Fluorescence (DMF) module, an UPlanFLN60×, NA = 1.2 oil immersion objective (Olympus, Tokyo, Japan) and a 6.4 μm/pixel CCD camera (QImaging, Canada).
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PMC11075223
The quality control of TCMs is the foundation for ensuring the effectiveness and safety of clinical medication.
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PMC10850553
Scale bar: 50 μm.
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PMC5839394
Interestingly, these evidences were confirmed by a differential proteomic analysis that highlighted important pathways involved in AgNPs-EPS toxicity, including endoplasmic reticulum stress, oxidative stress and mitochondrial impairment triggering cell death trough apoptosis and/or autophagy activation.
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PMC10976516
For at least 2 days, viral genomes remained throughout the body.
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PMC11766350
An important benefit is that the toxic transgene can be easily exchanged without the need to re-design the anti-shRNA cassette.
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PMC10094992
The monoclonal antibody anti human MPO and the PE conjugated goat anti-mouse were from eBiosciences-ThermoFisher, while the polyclonal antibody anti human Cit-Histone H3 (Arg2, Arg8, Arg17) was from Abbomax (San Jose, CA, USA).
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PMC7136814
However, we addressed primary resistance associated with each marker by calculating the absolute cell number of each cell subpopulation by flow cytometry in the whole population treated with scalar doses of Vincristine (Supplementary Figures and and supplementary methods).
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PMC10297204
Chronic exposure to ethanol, which is metabolically converted to acetaldehyde by alcohol dehydrogenase, P4502E1(CYP2E1), and catalase inside the body , is thought to cause axonal damage and demyelinating changes by decreasing myelin basic protein, neurofilament protein .
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PMC2777936
Where a value for statistical significance is indicated a two sample two-tailed t-test assuming unequal sample variances was performed.
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PMC11021472
We analyzed BL cells with and without miR-150 overexpression to determine whether miR-150 overexpression has an effect on the subcellular localization of the three ZDHHC11 transcripts.
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PMC11665555
The data were analyzed using DESeq2 (RRID:SCR_000154) R package (v. 3.3) to identify differentially expressed genes (DEGs), enrichment analysis, and Gene Ontology biological processes.
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PMC11264242
In this regard, we compared the SS18-SSX2 cases with the SS18-SSX2 cases but observed no difference in FYN gene expression between the two fusion types (Supplementary Figure S7).
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PMC11665584
The resources produced by this study, including the scRNA-Seq data, Xenium in situ data, and CUT&Tag-Seq data sets, will be helpful for future studies and serve as a model of how these newer technologies and comparative studies may be combined to glean deeper insights into biological processes.
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PMC9429973
The TE was an initial symptom of APL for 4 patients (40%).
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PMC10957991
On the right side panel, differences in junction protein area, interface occupancy and area of the junction protein, coverage index, intensity per interface, and cluster density in between ctrl and TRPV4 siRNA-treated 184A1 epithelial sheets are shown with box blots with inner and outer points and mean.
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PMC9429973
These results have since been verified in vitro using BTKi-treated patient samples, where we found a subset of U-CLL ‘Non/Reverse Responders’ to become ‘Sensitised’ to TLR9 activation in the presence of ibrutinib.
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PMC9596868
Primary antibodies used are as follows: mouse monoclonal anti-p53 (DO-1) from Santa Cruz Biotechnology, USA (Cat.
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PMC10237474
Cells were co-transfected with the PB vector and expression vector(s) that encodes GOI using Lipofectamine LTX (cat.
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PMC11489175
DUB enzymatic activity is regulated in a complex manner through allosteric and substrate-mediated effects 112.
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PMC10606998
The micrograph contrast is caused by the magnetite cores, while the dextran shells around the cores are only slightly noticeable as thin gaps (~1.5 nm) between dark spots.
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