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OTAR3088
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BioData-CellLine_annotated

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PMC7724160
If this condition is not met, the cell is marked is left blank.
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PMC8922418
Recently, the above CRISPR/Cas9 defects have been partially addressed and improved by researchers.
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PMC11300639
Total RNA was extracted from cells using TRIzol reagent (Termo Fisher Scientifc, USA).
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PMC9429973
However, C8 did not react with murine C3d.
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PMC9429973
Grade 3/4 hematologic AEs were anemia (4.1%), leukopenia (0.8%), thrombocytopenia (7.4%), while non-hematologic grade 3/4 AEs were infection (20.5%), GI-disorders (7.4%), hypertension (7.4%), renal and cardiac impairment/failure (6.6% and 8.2% respectively).
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PMC11357960
The patient was grouped into the low-risk group and scored as 1, if the percentage change in mRNA level of three genes in PBMC was less than 100 times and greater than -50.
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PMC11634794
The expression of LAMP1 protein in 786-O cells remained unchanged under different serum concentrations, whereas LC3C expression was upregulated under low serum conditions.
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PMC10882807
After 48 h, transfected cells were collected, and 3,000 cells/well were seeded in 96-well plates.
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PMC10391797
These findings pave the way for other CAR-T cell therapies to improve cytotoxic effects.
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PMC9429973
N. ANWAR, N. FATIMA, A. KHALID, L. MAJEED, M. BORHANY HEMATOLOGY; RESEARCH AND DEVELOPMENT, NATIONAL INSTITUTE OF BLOOD DISEASES AND BONE MARROW TRANSPLANTATION, KARACHI, Pakistan Background: Chemotherapy induced thrombocytopenia is perilous and may complicate disease treatment resulting in extended hospitalisation, bleeding, platelet transfusion and increase economic burden on the patients.
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PMC11489351
For example, studies have shown that decreased activity of Notch1 pathway members is associated with stem cell maintenance (49), while upregulation of Notch1 signaling is linked to cell commitment to differentiation in mammary models (50).
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PMC10547921
The crystal structure shows that the N-terminal dimethyl of compound 10 fits well in the receptor pocket and does not affect the overall binding affinity of the molecule (Fig. 4-1B).
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PMC11541409
Additionally, imatinib combined with RSL3 exhibited promising efficacy in imatinib-sensitive mutants .
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PMC9429973
Pts must not have prior treatment with epcoritamab or other bispecific antibodies targeting CD3 and CD20 and no autologous SCT ≤3 months before screening.
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PMC11640555
However, the lower concentration of 5 μM did not affect the apoptotic process (Figure 3G,H, densitometric analysis Figure 3(G1,H1)).
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PMC9429973
Nevertheless, there is not enough experience about the safety and feasibility of ASCT after anti-PD-1 in the context of possible immune-related adverse events (AE).
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PMC8658661
Changes in the AFP level also predict the course of disease, the therapeutic response, and the occurrence of relapse .
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PMC11509224
In our review of the literature on sponge-derived diterpenoids, we noticed that some molecules exhibit multiple activities.
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PMC7553912
Moreover, the expression of OSMRβ was hardly detected in the renal macrophages.
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PMC11402217
H–J) The immunofluorescence analysis of β-catenin in 143B cells after treated with XD23.
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PMC11531744
Immunohistochemical studies were performed on paraffin section with precipitation from cell centrifugation.
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PMC11758416
See Figures 3B and 3C.3.Incubate some L cells in CFSE only to serve as non-stimulating control.
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PMC8524093
The 3′ORF is translated from a positive-sense subgenomic mRNA (sgRNA) and codifies the structural proteins: capsid (C), envelope 3 (E3), envelope 2 (E2), 6K, and envelope 1 (E1) (Strauss and Strauss, 1994; Khan et al., 2002; Solignat et al., 2009; Silva and Dermody, 2017).
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PMC6182045
TZ97008-rgp120 from CHO and MGAT1 CHO expression systems, purified by affinity or ion exchange purification methods, respectively, were analyzed by two-dimensional isoelectric focusing gel analysis as previously described (9).
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PMC11747885
In total 18 derivatives (26–43) with R modifications were synthesized (Fig. 2B).
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PMC9164404
The results showed that the blood physiological and biochemical indexes were normal (Additional file 1: Fig. S6).
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PMC9429973
Methods: The CLL Collaborative Study of Real-World Evidence (CORE), a retrospective, international, observational study (23 centers) for CLL/SLL pts provided data for this analysis.
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PMC10656496
Additional contextual information was incorporated, including allele frequency in other studies such as 1000 Genomes, the NHLBI Exome Sequence Project, in silico functional impact predictions, and observed impacts from databases like ClinVar (http://www.ncbi.nlm.nih.gov/clinvar/) and the Collection of Somatic Mutations in Cancer (COSMIC).
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PMC10589262
One-way ANOVA with a post-hoc test was performed to compare multiple means (*p < 0.05, **p < 0.01, ***p < 0.001).
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PMC11509224
The in vitro anti-inflammatory activities of these compounds were tested by inhibition of LPS-induced NO production in RAW264.7 macrophages, with IC50 values of 32, 15, 12, 22, and 12 µM, respectively.
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PMC11247842
DRPs of both SCS and CM were analyzed in Brown Swiss and Original Braunvieh.
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PMC11402217
The relative positive area ratio of IHC staining for DKK1 (H) and β-catenin (I) in lung slices.(J) XD23’s mechanism of action against OS in vivo.
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PMC11665555
Metabolomic profiling was performed on 5637P, 5637GR, and GR-OXCT1KO cells.
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PMC6442998
Although that reduction of cell viability was incomplete, the adjunction of cilostazol lead to a remarkable tenfold reduction of the imatinib IC50 in the imatinib-resistant GIST48 cell line (Figure 1A), namely, IC50 for imatinib alone: ∼2.52 μM vs IC50 for imatinib + cilostazol: ∼0.18μM - in the range of imatinib IC50 in the imatinib-sensitive GIST882 cells (∼0.21 μM) .
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PMC9672323
Here, we designed an in vitro study to evaluate the effects of piroxicam on peripheral blood mononuclear cells (PBMCs) co-cultivated with two glioblastoma cell lines, U-87 malignant glioma (MG) and A-172 cells and to compare these effects with dexamethasone.
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PMC8557138
Morphological and functional heterogeneity along the vascular tree has been well documented (Gerritsen 1987; Castro et al. 2018).
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PMC9429973
Due to several reasons including the immaturity of these studies, various survival models have been used to extrapolate OS.
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PMC9429973
Aims: To evaluate the level of knowledge about infectious complications by hematologists, and to identify possible gaps that could help to design educational activities.
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PMC11539788
B-C) western blot analysis of RNF19A protein levels in T24 and 5637 cells after the knockdown of RNF19A and quantitative analysis. (
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PMC11451940
The half-maximal inhibitory concentrations (IC50) were calculated from dose–response curves by means of the GraphPad Prism 6 software (GraphPad Software, San Diego, USA).
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PMC11621493
Therefore, cells were seeded with a density of 2.5 × 10 cells/ml in the respective culture flask (see Cell culture).
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PMC10854447
NH3, THF, I2, r.t 3–5 h, 40–85%; (c) NH2OH·HCl, Na2CO3, methanol, reflux, 6–8 h; (d) CDI, dry CH3CN, r.t 10 h; (e) CH3CN, reflux, overnight, 46–90%.
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PMC11590870
Free radicals react with DNA, promoting the appearance of cancer cells.
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PMC11499381
Cy5-labelled CGRP (Cy5 label on position 3) was synthesized in-house as previously described .
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PMC9119314
Semi-synthesis of brominated and iodinated derivatives of 1.
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PMC10253973
A lot of metal ion complexes have significantly influenced the development of anti-tumor drugs because of their use in diagnostics and therapy .
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PMC11773391
MGMT inhibitors inhibit the expression of MGMT and regulate GSC resistance to TMZ .
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PMC11705067
The results showed that FDX1 and DLAT expression were markedly correlated with HMGB1, TLR4, CX3CL1, CD27, CCL5, CXCL10 and TNFRSF18 (Fig. 7C, 7D).
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PMC11711935
Recent studies have revealed that dermal fibroblasts regulate pigmentation by secreting soluble factors that influence melanocyte function through paracrine signaling.
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PMC7802142
According to Rajendran et al., MSC-derived EVs (MSC-EVs) have a potential to activate DP cells, prolonged survival, induce growth factor activation in vitro, and promotes hair growth in vivo .
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PMC11063646
In the context of (Table 6), it serves as an indicator of how well the model predictions align with the actual observed values.
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PMC7039683
We used the classifiers to predict the effects of 14 OFC-associated SNPs at 12q13 near KRT18.
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PMC9429973
Patients and treatment characteristics were analyzed.
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PMC10938336
The assay was used herein to measure cell viability.
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PMC11538390
Cases with CLP (n = 121; 62 females and 59 males) were defined using the ICD-10 code Q37, ICD9 code 7492[ABCDE], and ICD8 codes 74920 and 74924.
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PMC4685407
We investigated the expression levels of these methyltransferases using RT-PCR.
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PMC8345486
Molecular graphics for 3 and 7 were generated using DIAMOND software (Diamond, v4.6.3,) .
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PMC6742971
Peptide (Melan-A peptide EAAGIGILTV; “EAA”), titration curves in an IFN-γ Elispot assay, to determine the functional avidity of the clones used for the subsequent killing assays. (
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PMC11509224
Two diterpenes were produced by Hippospongia sponges.
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PMC10969097
In addition, the analysis of peripheral blood revealed a notable decrease in myeloid-derived suppressor cells (CD33+HLA-DR-) in patients who had complete or partial responses after 13 weeks of treatment with mushroom extract.
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PMC8009078
The RoG of each frame of the TMPRSS2 complex with the final proposed molecules was extracted and plotted against the time of simulation (Fig. 7).
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PMC11806613
Figure S1C).
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PMC11506827
The treatment with 200 μg/mL GEF followed by a 10 and 20 ng/mL TRAIL treatment decreased the A498 cell viability to 47.55 ± 2.57% and 21.77 ± 4.68%, respectively (Figure 1B).
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PMC2944824
and *** indicates significantly difference between knockout and wild-type at p<0.01 and p<0.001, respectively, which was determined with ANOVA and Tukey's post hoc test.
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PMC11705862
Further, silencing of all isoforms of CD59 including IRIS-1 and 2 reduced SNARE complex formation in cultured neurons (SH-SY5Y) leading to a reduction in noradrenaline secretion.
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PMC9250505
Therefore, it has been suggested that inhibition of either the RAS/MEK/ERK or PI3K/AKT/mTOR cascades may sensitize ovarian cancer cells to paclitaxel or cisplatin.
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PMC9100622
After centrifugation at 13,000 rpm for 30 min at 4 °C, the upper phase was removed and 9 volumes of methanol was added to the lower phase, followed by centrifugation at 13,000 rpm for 30 min at 4 °C.
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PMC11755467
For in vitro DICER1 assays in CEM-SS cell lysate, the labeled precursors were diluted 1:100 in H2O (final concentration 1 fMol/µL) while 1 µL was used for each assay.
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PMC6901583
Sectioning of the samples fixed in formalin and embedded in paraffin into 4-μm sections was performed.
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PMC10761571
Fatemeh Jafari Golrokh: Resources.
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PMC9429973
Summary/Conclusion: Based on these findings, initial screening for the JAK2 mutation and careful monitoring for thrombotic events should be performed in patients with MPN.
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PMC11577421
Rapigest was from Waters (USA).
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PMC8414691
P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the controls group (mock and scramble) by Fisher’s exact test Cell division defects found in SRCAP depleted HeLa cells 6.21 ± 4.43 ***(scramble) 8.45 ± 4.96 *(mock), ***(scramble) CB, chromatin bridges; CM, chromosome misalignments; LIB, long intercellular bridges; MC, multinucleated cells; MS, multipolar Spindles The results are expressed as mean ± SD values from three independent replicate experiments: *P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the controls group by Fisher’s exact test Notably, MS found in cells treated with SRCAP A are statistically significant (***) compared to scramble, but not to mock.
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PMC11365983
List of primary and secondary antibodies used can be found in Supplemental methods (Table S4).
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PMC7519871
The difference in binding energy is clear from the binding interaction.
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PMC9429973
Patients who have achieved complete response (CR) at PET/CT before cycle 5 will receive 2 more cycles of BV-Nivolumab+R-CHP (cycle 5 and 6) and BV-Nivolumab only for cycles 7 and 8.
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PMC9878278
Changes in mRNA transcripts of key antiviral genes were measured from extracted RNA by qRT-PCR, as described previously (Strange et al., 2021).
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PMC11495567
The cells were analyzed using the Keyence BZ-X800 microscope.
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PMC9429973
Aims: To investigate the preventive effect of low-dose porcine antithymocyte globulin (P-ATG) on graft versus host disease (GVHD) in HLA matched sibling donor transplantation.
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PMC11144382
In order to elucidate the role of NFIX mutations in MSS, we initially studied their effects on GFAP and BBX expression in fibroblast cell lines obtained from 5 MSS patients, and then utilized these fibroblasts and mouse embryonic fibroblasts (MEFs) derived from wild-type (Nfix) mice, heterozygous (Nfix, Nfix and Nfix) and homozygous (Nfix, Nfix and Nfix) mutant mouse models in hypothesis-free approaches of RNA sequencing and proteomic analyses (Figure S1).
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PMC11763111
The proportion of CAR-T cells in the blood was determined by flow cytometry, and the number of CAR-T cells per 100 μl of blood was calculated from the cell count data.
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PMC11766350
Another option might include transient delivery of short double-stranded siRNAs targeting the cytotoxic transgene, along with the three AAV plasmids.
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PMC11621493
Statistically significant differences are shown as: ∗P < 0.1; ∗∗P < 0.01; and ∗∗∗P < 0.001.
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PMC9429973
In 7 cases, plasma was administered in unforeseen situations, such as for the correction of laboratory abnormalities without clinical manifestations (4 cases) or for prophylaxis of invasive techniques without abnormal coagulation tests (2 cases).
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PMC6892818
Importantly, normal cells were completely refractory to CD40-mediated killing.
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PMC11190062
Indeed, both TLR4 and TLR9 activation significantly reduced MM cell sensitivity to both bortezomib and carfilzomib ( Figures 3A, B ).
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PMC9429973
Using AML BM samples, we found that IRAK4 nuclear expression in blasts was significantly correlated with activation of NF-kappaB as determined by nuclear accumulation of NF-kappaB p-p50 and p-p65 in 9/19 cases.
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PMC11742231
This research presents a novel methodology known as the Multi-channel Graph Attention Network with Adaptive Fusion (MGATAF) networks, offering an innovative approach to drug response prediction.
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PMC11698348
For calcium-induced keratinocyte differentiation analysis, PMEKs were differentiated following transfection by media supplementation with 2.0mM calcium.
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PMC11411131
In this study, MeHg-mediated defects in selenocysteine (Sec) incorporation were demonstrated using thioredoxin reductase 1 cDNA fused with the hemagglutinin tag sequence at the C-terminus.
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PMC10213199
MCL1 encodes an anti-apoptotic protein that belongs to the Bcl-2 family.
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PMC10589262
The activation status of the three sensors of the UPR pathways (ATF6, IRE1α, and PERK) was measured in the cell line panel shown in Fig. 4A.
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PMC11726183
A catalytic amount (2 to 3 drops) of acetic acid was added and refluxed for 4–6 hours.
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PMC11721277
Uptake in the stomach, small intestine, and large intestine was negligible at all doses tested (p > 0.05).
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PMC11045125
Importantly, because LMP1 expression in B cells potently enhances T cell recognition and killing of tumor cells through a variety of different mechanisms , restoring LMP1 expression in human BL tumors is predicted to be a powerful approach for enhancing the host immune response to these tumors.
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PMC11066331
We were then curious whether we can discriminate spectral patterns of SKOV3TUSC3 shRNA cells in two-component mixtures with SKOV3scrambled shRNA control cells using the same panel of peaks as described above.
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PMC11751675
Key structural features, such as the α-methylene-γ-lactone ring, contribute to its pharmacological efficacy, including its antiviral effects.
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PMC10454535
The gel was run at 110 V for one hour.
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PMC11538390
An in-depth description of Estonian Biobank can be found elsewhere.
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PMC11798926
The amount of SynDIG4 at PSD95 was quantified as the ratio of SynDIG4-PSD95 colocalized puncta to the total number of SD4 puncta.
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