OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11098378	Effector catalytic residues where substitution mutations were made are highlighted in red in AlphaFold structures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effector", "catalytic", "residues", "where", "substitution", "mutations", "were", "made", "are", "highlighted", "in", "red", "in", "AlphaFold", "structures", "." ] } ]
PMC8992508	Nevertheless, the concept that modulation of ABC efflux transporters may overcome MDR is still strong, and the search for new chemosensitizers is still ongoing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "the", "concept", "that", "modulation", "of", "ABC", "efflux", "transporters", "may", "overcome", "MDR", "is", "still", "strong", ",", "and", "the", "search", "for", "new", "chemosensitizers", "is", "still", "ongoing", "." ] } ]
PMC9429973	In pts with CLL, the overall response rate (ORR) was 63.6%, CR 27.3%, and PR rate 36.4%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "pts", "with", "CLL", ",", "the", "overall", "response", "rate", "(", "ORR", ")", "was", "63.6", "%", ",", "CR", "27.3", "%", ",", "and", "PR", "rate", "36.4", "%", "." ] } ]
PMC11706491	Airyscan microscopy of FLCCR strain.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Airyscan", "microscopy", "of", "FLCCR", "strain", "." ] } ]
PMC4005030	PCA along with positive controls exhibited dose-dependently antioxidant ability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "along", "with", "positive", "controls", "exhibited", "dose-dependently", "antioxidant", "ability", "." ] } ]
PMC11727145	In contrast, the late burn wound exudate is produced during the resolution of inflammation, where anti-inflammatory cytokines promote tissue regeneration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "the", "late", "burn", "wound", "exudate", "is", "produced", "during", "the", "resolution", "of", "inflammation", ",", "where", "anti-inflammatory", "cytokines", "promote", "tissue", "regeneration", "." ] } ]
PMC11755519	Mutations in FGFR3 are found in 75% of papillary tumors, while mutations in HRAS are found in 30% of cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutations", "in", "FGFR3", "are", "found", "in", "75", "%", "of", "papillary", "tumors", ",", "while", "mutations", "in", "HRAS", "are", "found", "in", "30", "%", "of", "cases", "." ] } ]
PMC11470999	Additionally, expression levels and correlation analyses for CIP2A in melanoma were retrieved from BEST (https://rookieutopia.hiplot.com.cn/app direct/BEST/).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "expression", "levels", "and", "correlation", "analyses", "for", "CIP2A", "in", "melanoma", "were", "retrieved", "from", "BEST", "(", "https://rookieutopia.hiplot.com.cn/app", "direct/BEST/", ")", "." ] } ]
PMC11351758	This is achieved through the transient or flicker opening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "achieved", "through", "the", "transient", "or", "flicker", "opening", "." ] } ]
PMC3681794	Error bars indicate SEM.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bars", "indicate", "SEM", "." ] } ]
PMC9429973	Demographic and clinical data were collected retrospectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Demographic", "and", "clinical", "data", "were", "collected", "retrospectively", "." ] } ]
PMC9693627	The supernatant was incubated first with 25 µg of recombinant 6xHis-tagged PTCD2 for 1 h at 4 °C with gentle agitation and then with Ni-NTA-Sepharose (Qiagene, Hilden, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "was", "incubated", "first", "with", "25", "µg", "of", "recombinant", "6xHis-tagged", "PTCD2", "for", "1", "h", "at", "4", "°", "C", "with", "gentle", "agitation", "and", "then", "with", "Ni-NTA-Sepharose", "(", "Qiagene", ",", "Hilden", ",", "Germany", ")", "." ] } ]
PMC11617590	Statistical significance was based on the difference compared with 0 μM SFN by one‐way ANOVA, followed by Dunnett's test (n = 3) (*p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", "was", "based", "on", "the", "difference", "compared", "with", "0", "μM", "SFN", "by", "one‐way", "ANOVA", ",", "followed", "by", "Dunnett", "'s", "test", "(", "n", "=", "3", ")", "(", "*", "p", "<", "0.05", ")", "." ] } ]
PMC11750712	The α/β T cell antigen receptor (TCR) complex is expressed by most healthy T cells and by nearly all cases of PTCL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "α/β", "T", "cell", "antigen", "receptor", "(", "TCR", ")", "complex", "is", "expressed", "by", "most", "healthy", "T", "cells", "and", "by", "nearly", "all", "cases", "of", "PTCL", "." ] } ]
PMC11742231	MGATAF significantly advances drug response prediction by effectively integrating multiple molecular data types and capturing complex interactions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MGATAF", "significantly", "advances", "drug", "response", "prediction", "by", "effectively", "integrating", "multiple", "molecular", "data", "types", "and", "capturing", "complex", "interactions", "." ] } ]
PMC10607604	Other groups then confirmed and extended this result to hepatocellular carcinoma and lung cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "groups", "then", "confirmed", "and", "extended", "this", "result", "to", "hepatocellular", "carcinoma", "and", "lung", "cancer", "." ] } ]
PMC11188874	We screened a library of 3,400 FDA-approved pharmacologics and bioactive molecules to identify agents that increased proteasome ChT-like activity (Fig. 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "screened", "a", "library", "of", "3,400", "FDA-approved", "pharmacologics", "and", "bioactive", "molecules", "to", "identify", "agents", "that", "increased", "proteasome", "ChT-like", "activity", "(", "Fig.", "1A", ")", "." ] } ]
PMC9454852	BOLD-100 (sodium trans-[tetrachlorobis(1H-indazole) ruthenate(III)]) is a clinical-stage therapeutic that has previously been tested in a phase 1 clinical trial as a monotherapy in advanced cancers , and is currently being tested in a phase 1b/2 clinical trial in combination with FOLFOX (fluorouracil, leucovorin and oxaliplatin) for the treatment of advanced gastrointestinal cancers (NCT04421820).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BOLD-100", "(", "sodium", "trans-[tetrachlorobis(1H-indazole", ")", "ruthenate(III", ")", "]", ")", "is", "a", "clinical-stage", "therapeutic", "that", "has", "previously", "been", "tested", "in", "a", "phase", "1", "clinical", "trial", "as", "a", "monotherapy", "in", "advanced", "cancers", ",", "and", "is", "currently", "being", "tested", "in", "a", "phase", "1b/2", "clinical", "trial", "in", "combination", "with", "FOLFOX", "(", "fluorouracil", ",", "leucovorin", "and", "oxaliplatin", ")", "for", "the", "treatment", "of", "advanced", "gastrointestinal", "cancers", "(", "NCT04421820", ")", "." ] } ]
PMC11413393	MS023 treatment could plausibly lead to unresolved DNA damage by impairing the function of these proteins leading to cell cycle arrest and eventual cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MS023", "treatment", "could", "plausibly", "lead", "to", "unresolved", "DNA", "damage", "by", "impairing", "the", "function", "of", "these", "proteins", "leading", "to", "cell", "cycle", "arrest", "and", "eventual", "cell", "death", "." ] } ]
PMC10968586	Four cycles of 150 mg/kg/week OLE in Sprague–Dawley rats reduced serum TNF-α and IL-6 in an experimental model of epirubicin and cyclophosphamide toxicity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "cycles", "of", "150", "mg/kg/week", "OLE", "in", "Sprague", "–", "Dawley", "rats", "reduced", "serum", "TNF-α", "and", "IL-6", "in", "an", "experimental", "model", "of", "epirubicin", "and", "cyclophosphamide", "toxicity", "." ] } ]
PMC11665555	Metabolic reprogramming is a hallmark of cancer due in part to the high energetic demands required to sustain tumor expansion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metabolic", "reprogramming", "is", "a", "hallmark", "of", "cancer", "due", "in", "part", "to", "the", "high", "energetic", "demands", "required", "to", "sustain", "tumor", "expansion", "." ] } ]
PMC7090062	After 24 h, cells were fixed in 3.7% formaldehyde for 20 min at room temperature, washed three times with phosphate-buffered saline (PBS), mounted on glass slides and examined using laser scanning confocal microscope (LSM 800).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "24", "h", ",", "cells", "were", "fixed", "in", "3.7", "%", "formaldehyde", "for", "20", "min", "at", "room", "temperature", ",", "washed", "three", "times", "with", "phosphate-buffered", "saline", "(", "PBS", ")", ",", "mounted", "on", "glass", "slides", "and", "examined", "using", "laser", "scanning", "confocal", "microscope", "(", "LSM", "800", ")", "." ] } ]
PMC8728081	As Kajjali contains a higher portion of nano-sized particles, the penetration capacity of Kajjali particles in the cell and nucleus is far higher compared to Rasasindura, which makes it more toxic in the cell line study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "Kajjali", "contains", "a", "higher", "portion", "of", "nano-sized", "particles", ",", "the", "penetration", "capacity", "of", "Kajjali", "particles", "in", "the", "cell", "and", "nucleus", "is", "far", "higher", "compared", "to", "Rasasindura", ",", "which", "makes", "it", "more", "toxic", "in", "the", "cell", "line", "study", "." ] } ]
PMC9964635	We have incorporated various electron-donating and electron-withdrawing groups into electrophiles to test structure–activity relationships at various concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "incorporated", "various", "electron-donating", "and", "electron-withdrawing", "groups", "into", "electrophiles", "to", "test", "structure", "–", "activity", "relationships", "at", "various", "concentrations", "." ] } ]
PMC9429973	Statistically, ANOVA and log rank tests were used to study the impact of comorbidities and response to treatment on MPN SAF score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistically", ",", "ANOVA", "and", "log", "rank", "tests", "were", "used", "to", "study", "the", "impact", "of", "comorbidities", "and", "response", "to", "treatment", "on", "MPN", "SAF", "score", "." ] } ]
PMC3274243	Although the data presented is derived from adherent cell cultures that have reached confluence, earlier monitoring has the potential to provide information on cell attachment, spreading and proliferation rates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "data", "presented", "is", "derived", "from", "adherent", "cell", "cultures", "that", "have", "reached", "confluence", ",", "earlier", "monitoring", "has", "the", "potential", "to", "provide", "information", "on", "cell", "attachment", ",", "spreading", "and", "proliferation", "rates", "." ] } ]
PMC11748363	Reactions employing phenylacetyl chlorides were performed in the presence of dry pyridine as a base.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reactions", "employing", "phenylacetyl", "chlorides", "were", "performed", "in", "the", "presence", "of", "dry", "pyridine", "as", "a", "base", "." ] } ]
PMC9429973	The version of MPN-SAF was not specified in 11 trials and that for MF-SAF in 2 trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "version", "of", "MPN-SAF", "was", "not", "specified", "in", "11", "trials", "and", "that", "for", "MF-SAF", "in", "2", "trials", "." ] } ]
PMC9429973	In the high-risk group, both unadjusted and adjusted analyses showed the VAS overall health score was improved after 2 cycles of treatment (figure and table); the FACT-Lym total score was also improved at some visits.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "high-risk", "group", ",", "both", "unadjusted", "and", "adjusted", "analyses", "showed", "the", "VAS", "overall", "health", "score", "was", "improved", "after", "2", "cycles", "of", "treatment", "(", "figure", "and", "table", ")", ";", "the", "FACT-Lym", "total", "score", "was", "also", "improved", "at", "some", "visits", "." ] } ]
PMC11803210	After 48 h, cells were treated with DMSO or Nar, and cell pellets were collected 24 h after treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "48", "h", ",", "cells", "were", "treated", "with", "DMSO", "or", "Nar", ",", "and", "cell", "pellets", "were", "collected", "24", "h", "after", "treatment", "." ] } ]
PMC11126803	B, at the protein level, ZEB1 was indeed increased after overexpression of LncRNA-SERB in A498 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "B", ",", "at", "the", "protein", "level", ",", "ZEB1", "was", "indeed", "increased", "after", "overexpression", "of", "LncRNA-SERB", "in", "A498", "cells", "." ] } ]
PMC11543935	Visualisation was achieved using a Rigol DS1054Z Digital-Oscilloscope (Rigol Technologies, Germany) which monitors the delivered voltage and current of the pulses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Visualisation", "was", "achieved", "using", "a", "Rigol", "DS1054Z", "Digital-Oscilloscope", "(", "Rigol", "Technologies", ",", "Germany", ")", "which", "monitors", "the", "delivered", "voltage", "and", "current", "of", "the", "pulses", "." ] } ]
PMC11718109	For days 5 and 6, a mixture of 75% KSR + 25% N2 medium also containing 500 nM LDN193189, 10 μM SB431542, 200 ng/ml SHH C25II (R&D Systems), 2 μM Purmorphamine (Cayman Chemical Company), 100 ng/ml FGF-8b (PeproTech) and 4 μM CHIR99021 (Tocris) was added to the cells followed by equal amounts of KSR and N2 media on days 7–8, and 25% KSR + 75% N2 media on days 9–10 also containing 500 nM LDN193189, 10 μM SB431542, 200 ng/ml SHH C25II and 4 μM CHIR99021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "days", "5", "and", "6", ",", "a", "mixture", "of", "75", "%", "KSR", "+", "25", "%", "N2", "medium", "also", "containing", "500", "nM", "LDN193189", ",", "10", "μM", "SB431542", ",", "200", "ng/ml", "SHH", "C25II", "(", "R&D", "Systems", ")", ",", "2", "μM", "Purmorphamine", "(", "Cayman", "Chemical", "Company", ")", ",", "100", "ng/ml", "FGF-8b", "(", "PeproTech", ")", "and", "4", "μM", "CHIR99021", "(", "Tocris", ")", "was", "added", "to", "the", "cells", "followed", "by", "equal", "amounts", "of", "KSR", "and", "N2", "media", "on", "days", "7–8", ",", "and", "25", "%", "KSR", "+", "75", "%", "N2", "media", "on", "days", "9–10", "also", "containing", "500", "nM", "LDN193189", ",", "10", "μM", "SB431542", ",", "200", "ng/ml", "SHH", "C25II", "and", "4", "μM", "CHIR99021", "." ] } ]
PMC9429973	Aims: We compared retrospectively the outcomes of DLBCL patients treated with R-CHOP in our center according to the COO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "We", "compared", "retrospectively", "the", "outcomes", "of", "DLBCL", "patients", "treated", "with", "R-CHOP", "in", "our", "center", "according", "to", "the", "COO", "." ] } ]
PMC11366496	Zhang et al. reported that HOXB9 achieves the suppression of pancreatic cancer cell proliferation via the DNMT1/RBL2/c‐Myc axis, which effectively blocks cell cycle progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zhang", "et", "al.", "reported", "that", "HOXB9", "achieves", "the", "suppression", "of", "pancreatic", "cancer", "cell", "proliferation", "via", "the", "DNMT1/RBL2/c‐Myc", "axis", ",", "which", "effectively", "blocks", "cell", "cycle", "progression", "." ] } ]
PMC9429973	The ACTIVE + G regimen consisted of Venetoclax 600mg/d p/o from day 1 up to day 28, Cytarabine 20mg/m2 s/c on days 1-10, Actinomycin D 12.5 µg/kg i/v on days 1-3 (on days 1-2 for patients ≥65 years) and Gilteritinib 120mg/d p/o starting from either day 4 or day 10 and continued up to day 28.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ACTIVE", "+", "G", "regimen", "consisted", "of", "Venetoclax", "600mg/d", "p/o", "from", "day", "1", "up", "to", "day", "28", ",", "Cytarabine", "20mg/m2", "s/c", "on", "days", "1", "-", "10", ",", "Actinomycin", "D", "12.5", "µg/kg", "i/v", "on", "days", "1", "-", "3", "(", "on", "days", "1", "-", "2", "for", "patients", "≥65", "years", ")", "and", "Gilteritinib", "120mg/d", "p/o", "starting", "from", "either", "day", "4", "or", "day", "10", "and", "continued", "up", "to", "day", "28", "." ] } ]
PMC11271278	All these results demonstrate that, on the chimeric MYC-ERBB2 ecDNA in NCIH2170 cells, while MYC retains its interaction with its endogenous enhancers, ERBB2 and its neighboring genes opportunistically hijack MYC enhancers on the same ecDNA for their transcriptional activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "these", "results", "demonstrate", "that", ",", "on", "the", "chimeric", "MYC-ERBB2", "ecDNA", "in", "NCIH2170", "cells", ",", "while", "MYC", "retains", "its", "interaction", "with", "its", "endogenous", "enhancers", ",", "ERBB2", "and", "its", "neighboring", "genes", "opportunistically", "hijack", "MYC", "enhancers", "on", "the", "same", "ecDNA", "for", "their", "transcriptional", "activation", "." ] } ]
PMC11449273	Mutants can be classified into two categories: conformational/structural and contact [3, 17, 20–23].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutants", "can", "be", "classified", "into", "two", "categories", ":", "conformational/structural", "and", "contact", "[", "3", ",", "17", ",", "20–23", "]", "." ] } ]
PMC11787355	tumors.	[ { "tags": [ "O", "O" ], "tokens": [ "tumors", "." ] } ]
PMC11727145	Altogether, the best media combination to prepare the DED model for testing the construct with HaCaT cells was to seed the cells in a complete medium and to culture the construct in mGreen’s medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Altogether", ",", "the", "best", "media", "combination", "to", "prepare", "the", "DED", "model", "for", "testing", "the", "construct", "with", "HaCaT", "cells", "was", "to", "seed", "the", "cells", "in", "a", "complete", "medium", "and", "to", "culture", "the", "construct", "in", "mGreen", "’s", "medium", "." ] } ]
PMC9164404	Since Pt(IV) drugs can be reduced to Pt(II) to exert anticancer efficacy, part of metabolites showed the same change trend in the two treatment groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "Pt(IV", ")", "drugs", "can", "be", "reduced", "to", "Pt(II", ")", "to", "exert", "anticancer", "efficacy", ",", "part", "of", "metabolites", "showed", "the", "same", "change", "trend", "in", "the", "two", "treatment", "groups", "." ] } ]
PMC9429973	Our register, in addition to identifying the epidemiological characteristics of the Brazilian multiple myeloma patients, demonstrates the treatment standards at the public and private institutions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "register", ",", "in", "addition", "to", "identifying", "the", "epidemiological", "characteristics", "of", "the", "Brazilian", "multiple", "myeloma", "patients", ",", "demonstrates", "the", "treatment", "standards", "at", "the", "public", "and", "private", "institutions", "." ] } ]
PMC11770130	We first generated Ntsr2 mice by knocking in the LoxP cassette before the first exon and after the last exon of the Ntsr2 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "generated", "Ntsr2", "mice", "by", "knocking", "in", "the", "LoxP", "cassette", "before", "the", "first", "exon", "and", "after", "the", "last", "exon", "of", "the", "Ntsr2", "gene", "." ] } ]
PMC9429973	Next, we explored whether C1 and C2 displayed a distinct immune profile.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "explored", "whether", "C1", "and", "C2", "displayed", "a", "distinct", "immune", "profile", "." ] } ]
PMC9000591	Moreover, the concomitant appearance of isoflavones, triterpenes, and lignans may have contributed to the biological activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "concomitant", "appearance", "of", "isoflavones", ",", "triterpenes", ",", "and", "lignans", "may", "have", "contributed", "to", "the", "biological", "activities", "." ] } ]
PMC10887351	In BC cell lines, pre-clinical studies have correlated the beta-blockers treatment with decreased cell proliferation and migration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "BC", "cell", "lines", ",", "pre-clinical", "studies", "have", "correlated", "the", "beta-blockers", "treatment", "with", "decreased", "cell", "proliferation", "and", "migration", "." ] } ]
PMC11751675	Moreover, two more sesquiterpene lactones, tashironin (50) and tashironin A (51), were also isolated from the roots of another species, Illicium verum Hook.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "two", "more", "sesquiterpene", "lactones", ",", "tashironin", "(", "50", ")", "and", "tashironin", "A", "(", "51", ")", ",", "were", "also", "isolated", "from", "the", "roots", "of", "another", "species", ",", "Illicium", "verum", "Hook", "." ] } ]
PMC9429973	TGFβ, whose local secretion is increased in MPNs, and more particularly in myelofibrosis is known to negatively regulate normal hematopoietic stem cells (HSC) proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TGFβ", ",", "whose", "local", "secretion", "is", "increased", "in", "MPNs", ",", "and", "more", "particularly", "in", "myelofibrosis", "is", "known", "to", "negatively", "regulate", "normal", "hematopoietic", "stem", "cells", "(", "HSC", ")", "proliferation", "." ] } ]
PMC11763126	qRT-PCR was performed using Applied Biosystems 7500 (Thermo Fisher, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "qRT-PCR", "was", "performed", "using", "Applied", "Biosystems", "7500", "(", "Thermo", "Fisher", ",", "USA", ")", "." ] } ]
PMC9503541	For the MS method type, SWATH-MS or the conventional All-ions method was chosen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "MS", "method", "type", ",", "SWATH-MS", "or", "the", "conventional", "All-ions", "method", "was", "chosen", "." ] } ]
PMC6901583	The tumor microenvironment that influences macrophage orientation and differentiation is influenced by the profile of chemokines at the tumor site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tumor", "microenvironment", "that", "influences", "macrophage", "orientation", "and", "differentiation", "is", "influenced", "by", "the", "profile", "of", "chemokines", "at", "the", "tumor", "site", "." ] } ]
PMC9429973	Results: Main results of the study are shown in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Main", "results", "of", "the", "study", "are", "shown", "in", "Table", "1", "." ] } ]
PMC9780037	Additional details of the cyt c therapeutic delivery systems, including model systems in which they have been tested and their inhibitory concentrations. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "details", "of", "the", "cyt", "c", "therapeutic", "delivery", "systems", ",", "including", "model", "systems", "in", "which", "they", "have", "been", "tested", "and", "their", "inhibitory", "concentrations", ".", "(" ] } ]
PMC10452486	These observations indicate that HLA-I variants, not only Face-2 but also Face3 and Face-4, may play a role in the pathogenesis of spondyloarthrpathies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "observations", "indicate", "that", "HLA-I", "variants", ",", "not", "only", "Face-2", "but", "also", "Face3", "and", "Face-4", ",", "may", "play", "a", "role", "in", "the", "pathogenesis", "of", "spondyloarthrpathies", "." ] } ]
PMC7961460	Mass calibration was performed using a peptide standard mixture provided by the manufacturer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mass", "calibration", "was", "performed", "using", "a", "peptide", "standard", "mixture", "provided", "by", "the", "manufacturer", "." ] } ]
PMC11064533	For the assay, a medium without antibiotics was used (later referred to as infection medium).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "assay", ",", "a", "medium", "without", "antibiotics", "was", "used", "(", "later", "referred", "to", "as", "infection", "medium", ")", "." ] } ]
PMC11666785	The centroid of extracted single molecules in each frame (say, n) are then compared with the single-molecule signatures in the preceding (frame #n − 1) and next frame (i.e, frame #n + 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "centroid", "of", "extracted", "single", "molecules", "in", "each", "frame", "(", "say", ",", "n", ")", "are", "then", "compared", "with", "the", "single-molecule", "signatures", "in", "the", "preceding", "(", "frame", "#", "n", "−", "1", ")", "and", "next", "frame", "(", "i.e", ",", "frame", "#", "n", "+", "1", ")", "." ] } ]
PMC4355729	Thus, our current study demonstrates that the downregulation of PIK3R1 contributes to progression and metastasis of RCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "our", "current", "study", "demonstrates", "that", "the", "downregulation", "of", "PIK3R1", "contributes", "to", "progression", "and", "metastasis", "of", "RCC", "." ] } ]
PMC6222635	The gel was selected after comparison with the protein marker, and the protein was transferred to a membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gel", "was", "selected", "after", "comparison", "with", "the", "protein", "marker", ",", "and", "the", "protein", "was", "transferred", "to", "a", "membrane", "." ] } ]
PMC9388315	Therefore, concentrations of 1.25, 2.50, and 5 mg/ml and 24 h were selected to continue the experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "concentrations", "of", "1.25", ",", "2.50", ",", "and", "5", "mg/ml", "and", "24", "h", "were", "selected", "to", "continue", "the", "experiments", "." ] } ]
PMC10729469	Representative images showing Iba1 reactive cells in brain regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "showing", "Iba1", "reactive", "cells", "in", "brain", "regions", "." ] } ]
PMC11087766	Among the 34 PhiKZ mutants we isolated, we observed 11 unique mutations in the picA gene (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "34", "PhiKZ", "mutants", "we", "isolated", ",", "we", "observed", "11", "unique", "mutations", "in", "the", "picA", "gene", "(", "Table", "1", ")", "." ] } ]
PMC11711347	The resulting precipitate was filtered, dried in a desiccator, and crystallized using a suitable solvent to obtain pure crystals, which were subsequently characterized and described (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulting", "precipitate", "was", "filtered", ",", "dried", "in", "a", "desiccator", ",", "and", "crystallized", "using", "a", "suitable", "solvent", "to", "obtain", "pure", "crystals", ",", "which", "were", "subsequently", "characterized", "and", "described", "(", "Figure", "1", ")", "." ] } ]
PMC11335267	During this process, transcription factors acting coordinately in a hierarchically organized manner activate lineage-specific gene expression programs to define cell-specific functions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "this", "process", ",", "transcription", "factors", "acting", "coordinately", "in", "a", "hierarchically", "organized", "manner", "activate", "lineage-specific", "gene", "expression", "programs", "to", "define", "cell-specific", "functions", "." ] } ]
PMC11462673	B Motif analysis of LDB1 binding sites in 6 T-CEM cells using Homer (22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Motif", "analysis", "of", "LDB1", "binding", "sites", "in", "6", "T-CEM", "cells", "using", "Homer", "(", "22", ")", "." ] } ]
PMC6600253	Moreover, M8 could accelerate the induction of senescence via an oxidative stress-dependent mechanism in human peritoneal mesothelial cells (HPMCs) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "M8", "could", "accelerate", "the", "induction", "of", "senescence", "via", "an", "oxidative", "stress-dependent", "mechanism", "in", "human", "peritoneal", "mesothelial", "cells", "(", "HPMCs", ")", "." ] } ]
PMC10957991	Junction Mapper analyses was used to screen differences in the parameters related to junctional integrity in ctrl and TRPV4-depleted 184A1 cell cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Junction", "Mapper", "analyses", "was", "used", "to", "screen", "differences", "in", "the", "parameters", "related", "to", "junctional", "integrity", "in", "ctrl", "and", "TRPV4-depleted", "184A1", "cell", "cultures", "." ] } ]
PMC9592219	Oncogenes often promote tumor progression by regulating the signaling pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oncogenes", "often", "promote", "tumor", "progression", "by", "regulating", "the", "signaling", "pathways", "." ] } ]
PMC10578720	It has been reported that as an NAD-dependent protein deacetylase, SIRT3 is recruited to deacetylate cccDNA while blocking the recruitment of histone methyltransferase to cccDNA, ultimately inhibiting cccDNA transcription in the hepatocyte.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "reported", "that", "as", "an", "NAD-dependent", "protein", "deacetylase", ",", "SIRT3", "is", "recruited", "to", "deacetylate", "cccDNA", "while", "blocking", "the", "recruitment", "of", "histone", "methyltransferase", "to", "cccDNA", ",", "ultimately", "inhibiting", "cccDNA", "transcription", "in", "the", "hepatocyte", "." ] } ]
PMC11033180	Quantitative analysis of mPSC frequency (G), amplitude (H), rise time (I), and half-width duration (J) reveal a significant difference in mPSC frequency between the Fc and Sema5A conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", "analysis", "of", "mPSC", "frequency", "(", "G", ")", ",", "amplitude", "(", "H", ")", ",", "rise", "time", "(", "I", ")", ",", "and", "half-width", "duration", "(", "J", ")", "reveal", "a", "significant", "difference", "in", "mPSC", "frequency", "between", "the", "Fc", "and", "Sema5A", "conditions", "." ] } ]
PMC7602170	Thereby c-KIT participates in GIST tumorigenesis by inducing proliferation and reducing apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thereby", "c-KIT", "participates", "in", "GIST", "tumorigenesis", "by", "inducing", "proliferation", "and", "reducing", "apoptosis", "." ] } ]
PMC9429973	Median overall survival (OS) from discontinuation of cBTKi therapy was 10.3 months (95% CI: 8.0-13.0 in US patients and 7.1 months (n=196, 95% CI: 4.6-12.7) in Japanese patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "overall", "survival", "(", "OS", ")", "from", "discontinuation", "of", "cBTKi", "therapy", "was", "10.3", "months", "(", "95", "%", "CI", ":", "8.0", "-", "13.0", "in", "US", "patients", "and", "7.1", "months", "(", "n=196", ",", "95", "%", "CI", ":", "4.6", "-", "12.7", ")", "in", "Japanese", "patients", "." ] } ]
PMC9429973	There is a lack of recent data to describe how mortality in patients with haematology malignancy has changed with widespread vaccination and several effective treatments now being available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "a", "lack", "of", "recent", "data", "to", "describe", "how", "mortality", "in", "patients", "with", "haematology", "malignancy", "has", "changed", "with", "widespread", "vaccination", "and", "several", "effective", "treatments", "now", "being", "available", "." ] } ]
PMC11753949	We conclude that expression of synaptopodin-ER generates ER specializations that can provide insight into mechanisms underlying formation of the spine apparatus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "conclude", "that", "expression", "of", "synaptopodin-ER", "generates", "ER", "specializations", "that", "can", "provide", "insight", "into", "mechanisms", "underlying", "formation", "of", "the", "spine", "apparatus", "." ] } ]
PMC11424574	An increasing number of studies suggest the involvement of aberrant MTA2 expression in tumor proliferation, metastasis, and chemotherapeutic agent resistance and indicate that MTA2 expression levels correlate with tumor characteristics such as size, grade, and lymph node metastasis in a variety of cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "increasing", "number", "of", "studies", "suggest", "the", "involvement", "of", "aberrant", "MTA2", "expression", "in", "tumor", "proliferation", ",", "metastasis", ",", "and", "chemotherapeutic", "agent", "resistance", "and", "indicate", "that", "MTA2", "expression", "levels", "correlate", "with", "tumor", "characteristics", "such", "as", "size", ",", "grade", ",", "and", "lymph", "node", "metastasis", "in", "a", "variety", "of", "cancers", "." ] } ]
PMC11269792	For actinomycin D treatment, RNA was treated with 2 mg/mL actinomycin D (Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "actinomycin", "D", "treatment", ",", "RNA", "was", "treated", "with", "2", "mg/mL", "actinomycin", "D", "(", "Sigma-Aldrich", ")", "." ] } ]
PMC11742290	To date, limited studies have investigated the relationship between LGR5 and angiogenesis in cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "date", ",", "limited", "studies", "have", "investigated", "the", "relationship", "between", "LGR5", "and", "angiogenesis", "in", "cancers", "." ] } ]
PMC8414691	Cells were stained with DAPI (blue) and anti-α-Tubulin (green).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "stained", "with", "DAPI", "(", "blue", ")", "and", "anti-α-Tubulin", "(", "green", ")", "." ] } ]
PMC11640247	These insights may ultimately contribute to the development of targeted therapeutic strategies for RAC3-related disorders.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "insights", "may", "ultimately", "contribute", "to", "the", "development", "of", "targeted", "therapeutic", "strategies", "for", "RAC3-related", "disorders", "." ] } ]
PMC9841531	Both column chromatography on silica gel (60–120 μm; Merck, Mumbai, India) and flash chromatography (Combiflash RF, Teledyne ISCO, NE, Lincoln) were used to accomplish the chromatographic purification using dichloromethane/methane 98%/2%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "column", "chromatography", "on", "silica", "gel", "(", "60–120", "μm", ";", "Merck", ",", "Mumbai", ",", "India", ")", "and", "flash", "chromatography", "(", "Combiflash", "RF", ",", "Teledyne", "ISCO", ",", "NE", ",", "Lincoln", ")", "were", "used", "to", "accomplish", "the", "chromatographic", "purification", "using", "dichloromethane/methane", "98%/2", "%", "." ] } ]
PMC10125312	Namely, an average increase of 0.28 °C, up to a maximum temperature of 34.58 °C, was observed for all six cell lines studied (Figure S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Namely", ",", "an", "average", "increase", "of", "0.28", "°", "C", ",", "up", "to", "a", "maximum", "temperature", "of", "34.58", "°", "C", ",", "was", "observed", "for", "all", "six", "cell", "lines", "studied", "(", "Figure", "S4", ")", "." ] } ]
PMC11541241	These studies made the TOR pathway another toehold in the plant response to recalcitrant fungal pathogens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "studies", "made", "the", "TOR", "pathway", "another", "toehold", "in", "the", "plant", "response", "to", "recalcitrant", "fungal", "pathogens", "." ] } ]
PMC11696659	Receiver Operating Characteristic (ROC) curves were used to characterize the performance of the models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Receiver", "Operating", "Characteristic", "(", "ROC", ")", "curves", "were", "used", "to", "characterize", "the", "performance", "of", "the", "models", "." ] } ]
PMC11486946	Because daunorubicin has an auto-fluorescence in the nucleus at 488 nm excitation, EGFR was observed using a second antibody at 640 nm excitation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "daunorubicin", "has", "an", "auto-fluorescence", "in", "the", "nucleus", "at", "488", "nm", "excitation", ",", "EGFR", "was", "observed", "using", "a", "second", "antibody", "at", "640", "nm", "excitation", "." ] } ]
PMC11665186	The correct affiliation of author “Mohammad Emad Olya” should read as “Laboratory of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland”	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "correct", "affiliation", "of", "author", "“", "Mohammad", "Emad", "Olya", "”", "should", "read", "as", "“", "Laboratory", "of", "Human", "Molecular", "Genetics", ",", "Institute", "of", "Molecular", "Biology", "and", "Biotechnology", ",", "Faculty", "of", "Biology", ",", "Adam", "Mickiewicz", "University", ",", "Poznań", ",", "Poland", "”" ] } ]
PMC11549062	The relative level of Rab5/GAPDH (n = 5). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "level", "of", "Rab5/GAPDH", "(", "n", "=", "5", ")", ".", "(" ] } ]
PMC11477621	NMR spectra were acquired on Varian Mercury 400, Bruker AM-400, and AM-500 spectrometers using CDCl3 or CD3OD as solvent (Bruker, Billerica, MA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NMR", "spectra", "were", "acquired", "on", "Varian", "Mercury", "400", ",", "Bruker", "AM-400", ",", "and", "AM-500", "spectrometers", "using", "CDCl3", "or", "CD3OD", "as", "solvent", "(", "Bruker", ",", "Billerica", ",", "MA", ",", "USA", ")", "." ] } ]
PMC9429973	Brown et al, Blood 2021.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Brown", "et", "al", ",", "Blood", "2021", "." ] } ]
PMC11791478	Biacore measurements were performed on a Biacore X100 instrument (GE Healthcare) at 25°C using a five-point titration of human or cynomolgus monkey TF (extracellular domain) in triplicate and analyzed using the recommended procedures (GE Healthcare).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Biacore", "measurements", "were", "performed", "on", "a", "Biacore", "X100", "instrument", "(", "GE", "Healthcare", ")", "at", "25", "°", "C", "using", "a", "five-point", "titration", "of", "human", "or", "cynomolgus", "monkey", "TF", "(", "extracellular", "domain", ")", "in", "triplicate", "and", "analyzed", "using", "the", "recommended", "procedures", "(", "GE", "Healthcare", ")", "." ] } ]
PMC9429973	Patients eligible for transplant have greater access to the procedure at private institutions than at public ones (p < 0.001), as well as to better chemotherapy induction protocols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "eligible", "for", "transplant", "have", "greater", "access", "to", "the", "procedure", "at", "private", "institutions", "than", "at", "public", "ones", "(", "p", "<", "0.001", ")", ",", "as", "well", "as", "to", "better", "chemotherapy", "induction", "protocols", "." ] } ]
PMC11564322	The data are presented as means ± SD of three independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "are", "presented", "as", "means", "±", "SD", "of", "three", "independent", "experiments", "." ] } ]
PMC9712534	The low nuclear mobility was not shared with other ICRF-resistant mutants and thus regarded as a characteristic feature of H58Y (Fig. 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "low", "nuclear", "mobility", "was", "not", "shared", "with", "other", "ICRF-resistant", "mutants", "and", "thus", "regarded", "as", "a", "characteristic", "feature", "of", "H58Y", "(", "Fig.", "4", ")", "." ] } ]
PMC11658074	Human fibroblasts treated with AT-EVs exhibited reduced senescence, as indicated by fewer SA-β-gal-positive cells (Fig. 3c, d), and decreased ROS accumulation, as measured via DCFH2-DA (Fig. 3g, h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "fibroblasts", "treated", "with", "AT-EVs", "exhibited", "reduced", "senescence", ",", "as", "indicated", "by", "fewer", "SA-β-gal-positive", "cells", "(", "Fig.", "3c", ",", "d", ")", ",", "and", "decreased", "ROS", "accumulation", ",", "as", "measured", "via", "DCFH2-DA", "(", "Fig.", "3", "g", ",", "h", ")", "." ] } ]
PMC9429973	T cell differentiation states (CD4 or CD8 naïve cells, stem cell memory cells, CM, effector memory (EM) or effector memory RA (EMRA) cells) and the proportion of TIGIT and TIM3 positive cells did not significantly differ between patients achieving CMR or not achieving CMR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T", "cell", "differentiation", "states", "(", "CD4", "or", "CD8", "naïve", "cells", ",", "stem", "cell", "memory", "cells", ",", "CM", ",", "effector", "memory", "(", "EM", ")", "or", "effector", "memory", "RA", "(", "EMRA", ")", "cells", ")", "and", "the", "proportion", "of", "TIGIT", "and", "TIM3", "positive", "cells", "did", "not", "significantly", "differ", "between", "patients", "achieving", "CMR", "or", "not", "achieving", "CMR", "." ] } ]
PMC9429973	Methods: a retrospective case-control study including 110 CDA-I patients (study group) and 326 age and sex-matched patients of the same ethnicity diagnosed with iron deficiency anemia (control group). .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "a", "retrospective", "case-control", "study", "including", "110", "CDA-I", "patients", "(", "study", "group", ")", "and", "326", "age", "and", "sex-matched", "patients", "of", "the", "same", "ethnicity", "diagnosed", "with", "iron", "deficiency", "anemia", "(", "control", "group", ")", ".", "." ] } ]
PMC11726848	This effect can also contribute to delayed cell death after HDR irradiation; however, the question if it is involved in the induction of cell cycle arrest should be clarified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "effect", "can", "also", "contribute", "to", "delayed", "cell", "death", "after", "HDR", "irradiation", ";", "however", ",", "the", "question", "if", "it", "is", "involved", "in", "the", "induction", "of", "cell", "cycle", "arrest", "should", "be", "clarified", "." ] } ]
PMC9583612	Although tanks contribute the majority of emissions in both basins, GPUs contribute only 14% of total emissions in basin A but 33% of total emissions in basin B. Thus, a nondominant equipment type in one basin could be a dominant equipment type in another, underscoring the need to understand basin characteristics to inform measurement and sampling procedures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "tanks", "contribute", "the", "majority", "of", "emissions", "in", "both", "basins", ",", "GPUs", "contribute", "only", "14", "%", "of", "total", "emissions", "in", "basin", "A", "but", "33", "%", "of", "total", "emissions", "in", "basin", "B.", "Thus", ",", "a", "nondominant", "equipment", "type", "in", "one", "basin", "could", "be", "a", "dominant", "equipment", "type", "in", "another", ",", "underscoring", "the", "need", "to", "understand", "basin", "characteristics", "to", "inform", "measurement", "and", "sampling", "procedures", "." ] } ]
PMC8913139	Furthermore, the TargetScan database (http://www.targetscan.org/) showed that miR-448 can bind to ROCK1 (Figure 3(a)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "TargetScan", "database", "(", "http://www.targetscan.org/", ")", "showed", "that", "miR-448", "can", "bind", "to", "ROCK1", "(", "Figure", "3(a", ")", ")", "." ] } ]
PMC11551844	Samples (3–5 μL) were transferred onto TEM (carbon) grids and letting them to absorb for 24 h. The size and structure of the particles were investigated using TEM (TESCAN VEGA 3 LMU microscope).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Samples", "(", "3–5", "μL", ")", "were", "transferred", "onto", "TEM", "(", "carbon", ")", "grids", "and", "letting", "them", "to", "absorb", "for", "24", "h.", "The", "size", "and", "structure", "of", "the", "particles", "were", "investigated", "using", "TEM", "(", "TESCAN", "VEGA", "3", "LMU", "microscope", ")", "." ] } ]
PMC11412721	Ackr4 and Cdkn1a mRNAs were quantified by RT-qPCR from Trp53 and Trp53 MEFs, untreated or treated with 10 μM Nutlin and/or 5 μg/ml 17-β estradiol (E2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ackr4", "and", "Cdkn1a", "mRNAs", "were", "quantified", "by", "RT-qPCR", "from", "Trp53", "and", "Trp53", "MEFs", ",", "untreated", "or", "treated", "with", "10", "μM", "Nutlin", "and/or", "5", "μg/ml", "17-β", "estradiol", "(", "E2", ")", "." ] } ]

PMC11098378

Effector catalytic residues where substitution mutations were made are highlighted in red in AlphaFold structures.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effector", "catalytic", "residues", "where", "substitution", "mutations", "were", "made", "are", "highlighted", "in", "red", "in", "AlphaFold", "structures", "." ] } ]

PMC8992508

Nevertheless, the concept that modulation of ABC efflux transporters may overcome MDR is still strong, and the search for new chemosensitizers is still ongoing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "the", "concept", "that", "modulation", "of", "ABC", "efflux", "transporters", "may", "overcome", "MDR", "is", "still", "strong", ",", "and", "the", "search", "for", "new", "chemosensitizers", "is", "still", "ongoing", "." ] } ]

PMC9429973

In pts with CLL, the overall response rate (ORR) was 63.6%, CR 27.3%, and PR rate 36.4%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "pts", "with", "CLL", ",", "the", "overall", "response", "rate", "(", "ORR", ")", "was", "63.6", "%", ",", "CR", "27.3", "%", ",", "and", "PR", "rate", "36.4", "%", "." ] } ]

PMC11706491

Airyscan microscopy of FLCCR strain.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Airyscan", "microscopy", "of", "FLCCR", "strain", "." ] } ]

PMC4005030

PCA along with positive controls exhibited dose-dependently antioxidant ability.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "along", "with", "positive", "controls", "exhibited", "dose-dependently", "antioxidant", "ability", "." ] } ]

PMC11727145

In contrast, the late burn wound exudate is produced during the resolution of inflammation, where anti-inflammatory cytokines promote tissue regeneration.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "the", "late", "burn", "wound", "exudate", "is", "produced", "during", "the", "resolution", "of", "inflammation", ",", "where", "anti-inflammatory", "cytokines", "promote", "tissue", "regeneration", "." ] } ]

PMC11755519

Mutations in FGFR3 are found in 75% of papillary tumors, while mutations in HRAS are found in 30% of cases.

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PMC11470999

Additionally, expression levels and correlation analyses for CIP2A in melanoma were retrieved from BEST (https://rookieutopia.hiplot.com.cn/app direct/BEST/).

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PMC11351758

This is achieved through the transient or flicker opening.

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PMC3681794

Error bars indicate SEM.

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PMC9429973

Demographic and clinical data were collected retrospectively.

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PMC9693627

The supernatant was incubated first with 25 µg of recombinant 6xHis-tagged PTCD2 for 1 h at 4 °C with gentle agitation and then with Ni-NTA-Sepharose (Qiagene, Hilden, Germany).

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PMC11617590

Statistical significance was based on the difference compared with 0 μM SFN by one‐way ANOVA, followed by Dunnett's test (n = 3) (*p < 0.05).

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PMC11750712

The α/β T cell antigen receptor (TCR) complex is expressed by most healthy T cells and by nearly all cases of PTCL.

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PMC11742231

MGATAF significantly advances drug response prediction by effectively integrating multiple molecular data types and capturing complex interactions.

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PMC10607604

Other groups then confirmed and extended this result to hepatocellular carcinoma and lung cancer .

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PMC11188874

We screened a library of 3,400 FDA-approved pharmacologics and bioactive molecules to identify agents that increased proteasome ChT-like activity (Fig. 1A).

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PMC9454852

BOLD-100 (sodium trans-[tetrachlorobis(1H-indazole) ruthenate(III)]) is a clinical-stage therapeutic that has previously been tested in a phase 1 clinical trial as a monotherapy in advanced cancers , and is currently being tested in a phase 1b/2 clinical trial in combination with FOLFOX (fluorouracil, leucovorin and oxaliplatin) for the treatment of advanced gastrointestinal cancers (NCT04421820).

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PMC11413393

MS023 treatment could plausibly lead to unresolved DNA damage by impairing the function of these proteins leading to cell cycle arrest and eventual cell death.

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PMC10968586

Four cycles of 150 mg/kg/week OLE in Sprague–Dawley rats reduced serum TNF-α and IL-6 in an experimental model of epirubicin and cyclophosphamide toxicity .

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PMC11665555

Metabolic reprogramming is a hallmark of cancer due in part to the high energetic demands required to sustain tumor expansion.

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PMC7090062

After 24 h, cells were fixed in 3.7% formaldehyde for 20 min at room temperature, washed three times with phosphate-buffered saline (PBS), mounted on glass slides and examined using laser scanning confocal microscope (LSM 800).

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PMC8728081

As Kajjali contains a higher portion of nano-sized particles, the penetration capacity of Kajjali particles in the cell and nucleus is far higher compared to Rasasindura, which makes it more toxic in the cell line study.

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PMC9964635

We have incorporated various electron-donating and electron-withdrawing groups into electrophiles to test structure–activity relationships at various concentrations.

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PMC9429973

Statistically, ANOVA and log rank tests were used to study the impact of comorbidities and response to treatment on MPN SAF score.

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PMC3274243

Although the data presented is derived from adherent cell cultures that have reached confluence, earlier monitoring has the potential to provide information on cell attachment, spreading and proliferation rates.

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PMC11748363

Reactions employing phenylacetyl chlorides were performed in the presence of dry pyridine as a base.

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PMC9429973

The version of MPN-SAF was not specified in 11 trials and that for MF-SAF in 2 trials.

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PMC9429973

In the high-risk group, both unadjusted and adjusted analyses showed the VAS overall health score was improved after 2 cycles of treatment (figure and table); the FACT-Lym total score was also improved at some visits.

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PMC11803210

After 48 h, cells were treated with DMSO or Nar, and cell pellets were collected 24 h after treatment.

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PMC11126803

B, at the protein level, ZEB1 was indeed increased after overexpression of LncRNA-SERB in A498 cells.

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PMC11543935

Visualisation was achieved using a Rigol DS1054Z Digital-Oscilloscope (Rigol Technologies, Germany) which monitors the delivered voltage and current of the pulses.

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PMC11718109

For days 5 and 6, a mixture of 75% KSR + 25% N2 medium also containing 500 nM LDN193189, 10 μM SB431542, 200 ng/ml SHH C25II (R&D Systems), 2 μM Purmorphamine (Cayman Chemical Company), 100 ng/ml FGF-8b (PeproTech) and 4 μM CHIR99021 (Tocris) was added to the cells followed by equal amounts of KSR and N2 media on days 7–8, and 25% KSR + 75% N2 media on days 9–10 also containing 500 nM LDN193189, 10 μM SB431542, 200 ng/ml SHH C25II and 4 μM CHIR99021.

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PMC9429973

Aims: We compared retrospectively the outcomes of DLBCL patients treated with R-CHOP in our center according to the COO.

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PMC11366496

Zhang et al. reported that HOXB9 achieves the suppression of pancreatic cancer cell proliferation via the DNMT1/RBL2/c‐Myc axis, which effectively blocks cell cycle progression.

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PMC9429973

The ACTIVE + G regimen consisted of Venetoclax 600mg/d p/o from day 1 up to day 28, Cytarabine 20mg/m2 s/c on days 1-10, Actinomycin D 12.5 µg/kg i/v on days 1-3 (on days 1-2 for patients ≥65 years) and Gilteritinib 120mg/d p/o starting from either day 4 or day 10 and continued up to day 28.

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PMC11271278

All these results demonstrate that, on the chimeric MYC-ERBB2 ecDNA in NCIH2170 cells, while MYC retains its interaction with its endogenous enhancers, ERBB2 and its neighboring genes opportunistically hijack MYC enhancers on the same ecDNA for their transcriptional activation.

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PMC11449273

Mutants can be classified into two categories: conformational/structural and contact [3, 17, 20–23].

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PMC11787355

tumors.

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PMC11727145

Altogether, the best media combination to prepare the DED model for testing the construct with HaCaT cells was to seed the cells in a complete medium and to culture the construct in mGreen’s medium.

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PMC9164404

Since Pt(IV) drugs can be reduced to Pt(II) to exert anticancer efficacy, part of metabolites showed the same change trend in the two treatment groups.

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PMC9429973

Our register, in addition to identifying the epidemiological characteristics of the Brazilian multiple myeloma patients, demonstrates the treatment standards at the public and private institutions.

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PMC11770130

We first generated Ntsr2 mice by knocking in the LoxP cassette before the first exon and after the last exon of the Ntsr2 gene.

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PMC9429973

Next, we explored whether C1 and C2 displayed a distinct immune profile.

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PMC9000591

Moreover, the concomitant appearance of isoflavones, triterpenes, and lignans may have contributed to the biological activities.

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PMC10887351

In BC cell lines, pre-clinical studies have correlated the beta-blockers treatment with decreased cell proliferation and migration .

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PMC11751675

Moreover, two more sesquiterpene lactones, tashironin (50) and tashironin A (51), were also isolated from the roots of another species, Illicium verum Hook.

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PMC9429973

TGFβ, whose local secretion is increased in MPNs, and more particularly in myelofibrosis is known to negatively regulate normal hematopoietic stem cells (HSC) proliferation.

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PMC11763126

qRT-PCR was performed using Applied Biosystems 7500 (Thermo Fisher, USA).

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PMC9503541

For the MS method type, SWATH-MS or the conventional All-ions method was chosen.

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PMC6901583

The tumor microenvironment that influences macrophage orientation and differentiation is influenced by the profile of chemokines at the tumor site.

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PMC9429973

Results: Main results of the study are shown in Table 1.

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PMC9780037

Additional details of the cyt c therapeutic delivery systems, including model systems in which they have been tested and their inhibitory concentrations. (

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PMC10452486

These observations indicate that HLA-I variants, not only Face-2 but also Face3 and Face-4, may play a role in the pathogenesis of spondyloarthrpathies.

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PMC7961460

Mass calibration was performed using a peptide standard mixture provided by the manufacturer.

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PMC11064533

For the assay, a medium without antibiotics was used (later referred to as infection medium).

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PMC11666785

The centroid of extracted single molecules in each frame (say, n) are then compared with the single-molecule signatures in the preceding (frame #n − 1) and next frame (i.e, frame #n + 1).

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PMC4355729

Thus, our current study demonstrates that the downregulation of PIK3R1 contributes to progression and metastasis of RCC.

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PMC6222635

The gel was selected after comparison with the protein marker, and the protein was transferred to a membrane.

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PMC9388315

Therefore, concentrations of 1.25, 2.50, and 5 mg/ml and 24 h were selected to continue the experiments.

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PMC10729469

Representative images showing Iba1 reactive cells in brain regions.

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PMC11087766

Among the 34 PhiKZ mutants we isolated, we observed 11 unique mutations in the picA gene (Table 1).

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PMC11711347

The resulting precipitate was filtered, dried in a desiccator, and crystallized using a suitable solvent to obtain pure crystals, which were subsequently characterized and described (Figure 1).

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PMC11335267

During this process, transcription factors acting coordinately in a hierarchically organized manner activate lineage-specific gene expression programs to define cell-specific functions.

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PMC11462673

B Motif analysis of LDB1 binding sites in 6 T-CEM cells using Homer (22).

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PMC6600253

Moreover, M8 could accelerate the induction of senescence via an oxidative stress-dependent mechanism in human peritoneal mesothelial cells (HPMCs) .

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PMC10957991

Junction Mapper analyses was used to screen differences in the parameters related to junctional integrity in ctrl and TRPV4-depleted 184A1 cell cultures.

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PMC9592219

Oncogenes often promote tumor progression by regulating the signaling pathways .

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PMC10578720

It has been reported that as an NAD-dependent protein deacetylase, SIRT3 is recruited to deacetylate cccDNA while blocking the recruitment of histone methyltransferase to cccDNA, ultimately inhibiting cccDNA transcription in the hepatocyte.

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PMC11033180

Quantitative analysis of mPSC frequency (G), amplitude (H), rise time (I), and half-width duration (J) reveal a significant difference in mPSC frequency between the Fc and Sema5A conditions.

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PMC7602170

Thereby c-KIT participates in GIST tumorigenesis by inducing proliferation and reducing apoptosis .

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PMC9429973

Median overall survival (OS) from discontinuation of cBTKi therapy was 10.3 months (95% CI: 8.0-13.0 in US patients and 7.1 months (n=196, 95% CI: 4.6-12.7) in Japanese patients.

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PMC9429973

There is a lack of recent data to describe how mortality in patients with haematology malignancy has changed with widespread vaccination and several effective treatments now being available.

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PMC11753949

We conclude that expression of synaptopodin-ER generates ER specializations that can provide insight into mechanisms underlying formation of the spine apparatus.

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PMC11424574

An increasing number of studies suggest the involvement of aberrant MTA2 expression in tumor proliferation, metastasis, and chemotherapeutic agent resistance and indicate that MTA2 expression levels correlate with tumor characteristics such as size, grade, and lymph node metastasis in a variety of cancers .

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PMC11269792

For actinomycin D treatment, RNA was treated with 2 mg/mL actinomycin D (Sigma-Aldrich).

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PMC11742290

To date, limited studies have investigated the relationship between LGR5 and angiogenesis in cancers.

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PMC8414691

Cells were stained with DAPI (blue) and anti-α-Tubulin (green).

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PMC11640247

These insights may ultimately contribute to the development of targeted therapeutic strategies for RAC3-related disorders.

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PMC9841531

Both column chromatography on silica gel (60–120 μm; Merck, Mumbai, India) and flash chromatography (Combiflash RF, Teledyne ISCO, NE, Lincoln) were used to accomplish the chromatographic purification using dichloromethane/methane 98%/2%.

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PMC10125312

Namely, an average increase of 0.28 °C, up to a maximum temperature of 34.58 °C, was observed for all six cell lines studied (Figure S4).

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PMC11541241

These studies made the TOR pathway another toehold in the plant response to recalcitrant fungal pathogens.

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PMC11696659

Receiver Operating Characteristic (ROC) curves were used to characterize the performance of the models.

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PMC11486946

Because daunorubicin has an auto-fluorescence in the nucleus at 488 nm excitation, EGFR was observed using a second antibody at 640 nm excitation.

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PMC11665186

The correct affiliation of author “Mohammad Emad Olya” should read as “Laboratory of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland”

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PMC11549062

The relative level of Rab5/GAPDH (n = 5). (

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PMC11477621

NMR spectra were acquired on Varian Mercury 400, Bruker AM-400, and AM-500 spectrometers using CDCl3 or CD3OD as solvent (Bruker, Billerica, MA, USA).

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PMC9429973

Brown et al, Blood 2021.

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PMC11791478

Biacore measurements were performed on a Biacore X100 instrument (GE Healthcare) at 25°C using a five-point titration of human or cynomolgus monkey TF (extracellular domain) in triplicate and analyzed using the recommended procedures (GE Healthcare).

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PMC9429973

Patients eligible for transplant have greater access to the procedure at private institutions than at public ones (p < 0.001), as well as to better chemotherapy induction protocols.

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PMC11564322

The data are presented as means ± SD of three independent experiments.

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PMC9712534

The low nuclear mobility was not shared with other ICRF-resistant mutants and thus regarded as a characteristic feature of H58Y (Fig. 4).

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PMC11658074

Human fibroblasts treated with AT-EVs exhibited reduced senescence, as indicated by fewer SA-β-gal-positive cells (Fig. 3c, d), and decreased ROS accumulation, as measured via DCFH2-DA (Fig. 3g, h).

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PMC9429973

T cell differentiation states (CD4 or CD8 naïve cells, stem cell memory cells, CM, effector memory (EM) or effector memory RA (EMRA) cells) and the proportion of TIGIT and TIM3 positive cells did not significantly differ between patients achieving CMR or not achieving CMR.

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PMC9429973

Methods: a retrospective case-control study including 110 CDA-I patients (study group) and 326 age and sex-matched patients of the same ethnicity diagnosed with iron deficiency anemia (control group). .

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PMC11726848

This effect can also contribute to delayed cell death after HDR irradiation; however, the question if it is involved in the induction of cell cycle arrest should be clarified.

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PMC9583612

Although tanks contribute the majority of emissions in both basins, GPUs contribute only 14% of total emissions in basin A but 33% of total emissions in basin B. Thus, a nondominant equipment type in one basin could be a dominant equipment type in another, underscoring the need to understand basin characteristics to inform measurement and sampling procedures.

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PMC8913139

Furthermore, the TargetScan database (http://www.targetscan.org/) showed that miR-448 can bind to ROCK1 (Figure 3(a)).

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PMC11551844

Samples (3–5 μL) were transferred onto TEM (carbon) grids and letting them to absorb for 24 h. The size and structure of the particles were investigated using TEM (TESCAN VEGA 3 LMU microscope).

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PMC11412721

Ackr4 and Cdkn1a mRNAs were quantified by RT-qPCR from Trp53 and Trp53 MEFs, untreated or treated with 10 μM Nutlin and/or 5 μg/ml 17-β estradiol (E2).

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