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PMC11699178
Data for ovarian serous cystadenocarcinoma from TCGA and corresponding normal tissue data from GTEx were retrieved from the Xiantao Academic website (TCGA_GTEx-OV).
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PMC11285179
G The protein level of DHRS11 and RDH13 stimulated with or without CCL28 and CCR3 neutralizing antibody in pericytes (left) and gray value was calculated(right).
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PMC11371747
Because of the shortage of chemotherapeutics, including dl-LV, interests in alternatives including l-LV (marketed as Fusilev/levoleucovorin) has renewed research regarding its optimal administration in the treatment of these malignancies (Kovoor et al., 2009; Fujii et al., 2011; Chuang and Suno, 2012; Hayes et al., 2014; Danenberg et al., 2016).
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PMC9352806
Fig. 3 BMS altered lipophagy-related genes and proteins levels.
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PMC11721064
p < 0.05, **p < 0.01, ***p < 0.001 Utilization of KSFM and Matrigel improved the adhesion and stemness maintenance of keratinocyte progenitor cells.
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PMC9429973
Summary/Conclusion: Сo-expression of p16+/p53+ biomarkers is associated with lower OS in DLBCL patients compared to other combinations of their expression.
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PMC11222184
qRT-PCR and western blotting analyzes show that XL-888 and Debio0932 can be used as a promising agent in therapy in neuroblastoma cell line SH-SY5Y and are effective in many cancer-related pathways.
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PMC11740573
On the other hand, a weaker synergistic effect observed in gram-negative bacteria can be related to the presence of the outer membrane in these bacteria.
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PMC11706297
Three subsequent synthetic steps were followed until new naphthalene-linked pyrazoline-thiazole hybrids (BTT-1–10 and BTP-1–10) were obtained.
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PMC9429973
The vast majority of MPN patients experienced symptoms (95%); more than 80% had fatigue and inactivity.
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PMC10213199
For the cell line analysis, 19 co-differential genes were compared between different concentrations of the 60 cell line, of which three genes were upregulated: LOC107987457 (phostensin-like gene), HSPA1A (heat shock protein family A member 1 A), and H2AC19 (H2A clustered histone 19).
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PMC9429973
33% had hypercalcemia (n=9), 19% had kidney involvement (n=5), 57% had anemia (n=16), and 75% had bone (n=21) at the time of diagnosis.
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PMC11772585
n = 5. **
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PMC10976516
However, some of the latter problems can by now be bypassed through advances in genetically engineered mouse models that generate humanized mice with a (partially) reconstituted human adaptive and/or innate immunity.
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PMC9429973
dPCR assays were performed on the QIAcuity One platform (QIAgen, Germany).
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PMC9479186
Transwell assay showed that compared with Lv-shCtrl group, the invasion of cells in the Lv-shNDUFC1 infection group was significantly inhibited in a time-dependent manner, with the inhibition rate at 67% (P < 0.01, Figures 2 C, D ) in BEL-7404 cells and 63% (P < 0.001) in SK-HEP-1.
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PMC11648299
The index date was in the time period of January 1, 2006 to December 31, 2015.
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PMC10993311
The ITGA4 module related to 21 biological processes and 5 diseases, targeting to blood coagulation diseases and cell adhesion.
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PMC11769516
The mycotoxin is a member of the class of 2-benzofurans that is 2-benzofuran-1(3H), one which is substituted at positions 4, 5, 6 and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl and hydroxy groups, respectively (Figure 6).
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PMC7917457
Complete responders from each group were rechallenged with another injection of the same tumor cells into their contralateral flanks to assess if these mice had acquired treatment-induced systemic anti-tumor T cell immunity against the cancer cells.
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PMC2777936
The distinct chromatin structure of EC and ES cells may be responsible for the lack of β-catenin-mediated transcription and it has been proposed that one role of POU5F1 is to block canonical Wnt signalling .
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PMC11453853
Further studies to elucidate these mechanisms are ongoing.
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PMC9985266
Subsequently, the purified DNA was collected for MSP amplification.
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PMC11267830
d Kaplan‒Meier curves displaying the survival duration of the mice.
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PMC5261804
This superpathway was a subset of the NCI Pathway Interaction Database that is now hosted by the public network data exchange (http://www.ndexbio.org/).
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PMC9429973
However better quality of care was received by only those patients who were educated and wealthy and could afford international consultations both online and personal visits.
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PMC9341513
In brief, chromatin is represented as a chain of beads (each representing a 1-kbp region), and we evolve the configuration of this chain using a molecular dynamics scheme and the LAMMPS simulation software (Plimpton 1995).
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PMC10759659
Furthermore, IHC staining for TIM-3 and ARID1A in human HCC samples confirmed a strong negative correlation between the levels of these two proteins (Fig. 5f).
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PMC11725127
The IC50 value of GA for inhibiting USP2 was determined to be 1.8 μmol/L (Fig. 2J).
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PMC9429973
Each lab parameter was modeled with sex, age, disease duration, and TE history at enrollment as baseline covariates and treatment as a time-dependent covariate.
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PMC11389534
UFBP1 is the first identified substrate of UFMylation.
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PMC9429973
Concomitant mutations in FLT3-ITD were detected in 2 patients.
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PMC10823017
The results show that Caki-1 cells have about a 51% (P<0.001) knockdown of p-Akt1 (Ser473) and a 27.8% (P<0.001) decreased activation of p-ERK1/2 ( Figure 6B ).
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PMC11139449
It employs the homology-mediated end-joining (HMEJ) strategy and efficiently integrates double-strand linearized DNA.
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PMC11541409
Metabolic inhibition should be combined with TKIs to enhance therapy for GIST.
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PMC9429973
K. Sychevskaya, S. Kravchenko, F. Babaeva, A. Misyurina, A. Korneeva, A. Abdulpatahov, R. Abdurashidova, A. Keniaykina, Z. Sarakaeva, E. Fastova, L. Gorenkova, E. Nesterova, Y. Mangasarova, M. Bagova, O. Margolin, A. Magomedova National Research Center for Hematology, Moscow, Russian Federation (Russia), Moscow, Russia Background: Optimization of Non-Hodgkin’s lymphomas (NHL) treatment during the COVID-19 pandemic is urgently needed.
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PMC9429973
A lower rate of serious AEs of any Gr was observed in pts aged ≥65 years (37% vs 52%).
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PMC11687167
③ CAP1 binds to CHRD and promotes degradation of the PCSK9-LDLR complex in lysosomes.
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PMC9429973
Placebo will be dosed at the same frequency as magrolimab.
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PMC11675244
Relapse and metastasis are the major challenges that stand in the way of cancer healing and survival, mainly attributed to cancer stem cells (CSCs).
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PMC8316344
Ferroptosis is defined as an iron-dependent regulated necrosis involving excessive lipid peroxidation, and is distinct from apoptosis, necrosis, and autophagy .
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PMC11748335
The text on the far right shows the proportion of tumor-gain LOCKs in I- or L-PMDs with decreased, unchanged, or increased H3K9me3 signals.
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PMC7602170
Further therapeutic approaches are urgently needed.
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PMC11679892
Similarly, it has been reported that doses in the range of 100–400 µg/mL are generally used in studies for the effects of plant extracts on cancer cells .
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PMC2196094
In two of these three proteases, RMCP-5 and -6, several differences in sequence were found between ours and the sequences determined by PCR amplification by Ide et al. (Figs. 2 A and 3) (24, 25).
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PMC9268620
The cells were then harvested every 8 h for 3 days (72 h), and the viability was measured by staining the cells with 0.25% trypan blue (Sigma, St. Louis, MO, USA) at a dilution of 1:1 and counting with a Neubauer hemocytometer under a light microscope.
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PMC11676169
Immune complexes were then analyzed by SDS-PAGE and immunoblot.
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PMC7612475
Although, more recently, this activity of XRCC3 has been disputed (36).
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PMC9080589
In this study, we observed that overexpression of PCDH8 dramatically suppressed PTC cell migration/invasion in vitro, as well as prevented the EMT phenotype in PTC cells.
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PMC11758416
Using a multichannel pipette remove ∼220 μL of supernatant without disturbing the cells and store immediately at −80°C for future further analysis.
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PMC11803149
Treatment with Epas1-Crispr significantly reduced expression of Epas1 mRNA ( Supplementary Figure S4A ).
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PMC11740907
The quantification of DNA damage may be accomplished by analyzing the disparity in the amount of DNA between the head and tail parts of the comet.33,34Table 4An Examination of Various Aspects Pertaining to the Comet Assay on the HeLa Cell Line Utilizing Purified P5W30 and P5W30-BW-SLNsParameters of Comet AssayPure P5W30P5W30-BW-SLNsH2O2L-Head227185143L-Tail7187146L-Comet298272289Head-DNA95.0888.3373.90Tail-DNA4.9111.6626.09TM3.4910.1438.10OTM6.9513.0728.89 An Examination of Various Aspects Pertaining to the Comet Assay on the HeLa Cell Line Utilizing Purified P5W30 and P5W30-BW-SLNs The flow cytometry method was used to get more understanding of the phases of cell cycle arrest, mitochondrial function and apoptosis.78 The flow cytometry experiment confirmed the quantitative aspect of the previously subjective findings on cancer cell death.
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PMC9841531
Concentration-effect curves of the antineoplastic agent 33 without (solid circles) and with 50 nM (solid up triangles), 100 nM (solid down triangles), and 500 nM (solid diamonds) of either compound 24 (A) or 30 (B) as determined in an MTT-based cell viability assay using MCT1-expressing A-549 cells.
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PMC5874706
The suspensions of nanoparticles charged in THN7 (1 mL) were introduced into a dialysis tube (Sigma, Pur-A-Lyzer Mega 1000 Dialysis Kit, MWCO: 1 kDa).
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PMC11707832
This altered glycosylation leads to immune recognition of new glycosyl epitopes, often linked to various autoimmune syndromes .
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PMC11363012
To accurately identify and quantify levels of metabolites in a single cell, we used external calibration curves of the authentic standards to convert the measured peak area for each compound into an absolute quantity.
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PMC5415764
H NMR of the PLGA-SS-PTX conjugate was performed using deuterated DMSO as a solvent.
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PMC11714165
All the membranes were blocked in a commercial quick blocking buffer (Beyotime) for 10 min before being incubated overnight with primary antibodies targeting GAPDH, NFκB p65, p‐NFκB p65, IκBα, and p‐IκBα.
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PMC6222726
The authors found that hinokinin did not increase DNA damage, demonstrating the absence of mutagenic and genotoxic activities.
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PMC11657744
Specifically, CEP89 and FBF1 contribute to ciliary disassembly by regulating Aurora A kinase stability and basal body localization CEP89 and FBF1 promote ciliary disassembly by regulating Aurora A kinase. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "CEP89", "and", "FBF1", "contribute", "to", "ciliary", "disassembly", "by", "regulating", "Aurora", "A", "kinase", "stability", "and", "basal", "body", "localization", "CEP89", "and", "FBF1", "promote", "ciliary", "disassembly", "by", "regulating", "Aurora", "A", "kinase", ".", "(" ] } ]
PMC6133382
This initial structure is sequentially trimmed to Man9GlcNAc2 and then Man5GlcNAc2 (center) as the protein moves from the ER to the Golgi apparatus.
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PMC11656380
The scale bar indicated 10 μm. (
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PMC8623816
Similar to viruses of the family Partitiviridae, the genomic sequence of RsRV5 also consists of two essential dsRNA segments, i.e., dsRNA-1, 1894 bp and dsRNA-2, 1755 bp.
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PMC4659567
In other words, addition of D2O into the DMF-d 7 solution of 8 led to its complete decomposition connected with a release of 3I5Braza (Fig 4).
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PMC11036064
For this aim, we accessed the miRTarbase database via the MIENTURNET.
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PMC6450504
Cell viability and investigation of PTX course of action on HeLa cells. (
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PMC9429973
A characteristic of all structural hemoglobinopathies, exception made of HbE, and of BT is the decreased red cells osmotic fragility (Omin) and dehydration (Ohyper) that is specially marked for HbC, HbSS and BT.
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PMC11794568
We observed that in melanoma models, CRIP1 may limit tumor energy supply through regulation of mitochondrial biogenesis, thereby limiting tumor cell proliferation and invasion, but not affecting the apoptotic.
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PMC9429973
5-year TTT-free survival was 60% (95%CI:44-82%) in patients aged ≤40 years (n=36), but only 33% (95%CI: 23-49%) in patients aged >40 years (n=81).
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PMC9429973
After a median 38 month follow up time; The 5-year progression-free survival rate was 49.7% in the good mobilizers arm and 48.6% in the poor mobilizers arm, with a median PFS of 73 months in the good mobilizers arm and 59 months in the poor mobilizers arm, and no significant difference was found between the two groups in terms of PFS.
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PMC11794847
However, while many NSCLC patients respond favorably to immunotherapy, a subset remains unresponsive .
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PMC11653533
However, ethanolic extract of F. racemosa bark and fruit has evinced vigorous antinociceptive activity on acetic acid-induced writhing in mice, where 500 mg/kg of fruit extract inhibited 61.38 % Writhing and 500 mg/kg bark extract inhibited 42.76 % Writhing (Ferdous et al., 2008).
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PMC9429973
Demographics and disease status were reasonably balanced across the groups (see Table 1 below) as was percentage of commonly associated genetic mutations (TET2, DNMT3A, SF3Baa, RUNX1, and TP53).
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PMC11766332
Additionally, several ASD-miRNA targets overlap with ASD-risk glycogenes .
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PMC10669966
Due to its rarity, collecting large sample series has been challenging and no definite genetic aberrations or specific therapy targets of PLPS have been identified .
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PMC9429973
The mechanisms that are responsible for CML relapses remain elusive.
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PMC11723947
Image Studio Software was used for total and target protein quantification.
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PMC11607321
A significant advantage of multi-omic vertical integration and unsupervised deep-generative models is their ability to synthetically generate datasets that are missing in specific samples, such as reconstructing a dataset that is entirely absent for certain cell lines.
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PMC11746942
Mechanistically, we identified a novel S1PR3-Src-STAT3 signaling axis that drives both early and sustained STAT3 activation in keratinocytes through Gαi/PKA signaling.
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PMC11286266
FURIN deletion synergised with S1P inhibitors in attenuating ATF6α signalling.
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PMC11332076
A K-Ras-derived farnesylation signal was add to the C-terminus for membrane localization.
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PMC11001582
n = 3 mice per genotype, one-way ANOVA, Bonferroni’s multiple comparison.
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PMC11477621
Then, SA-XL665 (#610SAXLG, Cisbio, Bedford, MA, USA) and anti-H3K9me0-Eu(K) (#61KB0KAD, Cisbio, USA) were added.
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PMC11257203
It has little intrinsic toxicity but exhibits a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer properties (10).
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PMC9429973
However, whether these deficiencies are associated with cellular metabolic changes has not been hitherto addressed.
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PMC9429973
P. Beer, H. Asnagli, N. Minet, E. Hoeben, A. Parker, A. Fischer, S. Latour Step Pharma, Saint-Genis-Pouilly; Laboratory of Lymphocyte Activation and Susceptibility to EBV infection, Imagine Institute; Université de Paris, Paris, France Background: T cell lymphomas are rare haematological cancers characterised by poor response to cytotoxic chemotherapy with resulting unmet clinical need.
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PMC10452486
The induction of HLA-G in macrophages and monocytes with proinflammatory cytokines such as IFN-γ was observed .
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PMC9429973
Aims: Our preclinical data demonstrated that CAR-T cells with decreased HPK1 expression had significantly enhanced antitumor effects and did not induce higher grade CRS .
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PMC6835428
One of the major problems with HGSOC is the occurrence of drug resistance.
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PMC11711871
These mice did not present hypercorticosteronemia, and on a high-salt diet, their systolic blood pressure was not different from that of the controls, although these mutant mice showed a significant increase in diastolic blood pressure.
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PMC9429973
Methods: Data were collected from 131 adult patients with an initial diagnosis of ALL treated at the Department of Medical Oncology and Hematology, University Hospital Zurich, Switzerland.
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PMC11423992
Compared to the previously reported Duobody-CD3/CD20 mediated T cells killing JeKo-1 cells, the maximum efficacy in terms of lethality reaches approximately 60%, and the potency of antibody-mediated T-cell cytotoxicity is comparable; however, the EC50 values for TFAB002s are higher, approximately an order of magnitude greater than that observed for Duobody-CD3/CD20 .
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PMC8873393
The integrity of the RNA was tested on a denaturing agarose gel.
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PMC11699178
No: 11875119) containing 1 μM GEM at 37 °C for 5 days, with one medium change during the treatment.
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PMC8633974
Seven HIV-1 molecular clones, one laboratory (NL4-3) plus six clade B founder strains, were included to reflect predominant North American and European viral subtype sequence heterogeneity.
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PMC8345486
A summary of the selection of the lead compound is shown in Figure 14.
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PMC7342409
Western blotting was used to analyze the role of autophagy and apoptosis in GIST cells with CQ alone, imatinib alone, or in combination, and to analyze MAPK pathway expression.
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PMC11443022
Similar conditions involving sex chromosome mosaicism with mixed gonadal dysgenesis includes variations such as 45,X/46,XY,/47,XXY and 45,X/47,XXY.
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PMC11626627
Luciferase assays were performed in 786-O cells transduced with GP-miRGLO, TWIST1–3′UTR-WT+mimics NC, TWIST1–3′UTR-WT+mimics+miR, TWIST1–3′UTR-Mut+mimics NC, and TWIST1–3′UTR-Mut+mimics+miR. Data are presented as mean ± SD. *
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PMC11247842
A promising approach to mitigate its negative effects is to genetically improve the resistance of dairy cattle to mastitis.
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