OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11257988	The chemical structure of the KRASG12D inhibitor MRTX1133.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chemical", "structure", "of", "the", "KRASG12D", "inhibitor", "MRTX1133", "." ] } ]
PMC11756514	Nonetheless, CP can shield S. aureus from opsonization and phagocytosis (26, 57) and, as we show here, can impede recognition of the microorganism by several PPRs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ",", "CP", "can", "shield", "S.", "aureus", "from", "opsonization", "and", "phagocytosis", "(", "26", ",", "57", ")", "and", ",", "as", "we", "show", "here", ",", "can", "impede", "recognition", "of", "the", "microorganism", "by", "several", "PPRs", "." ] } ]
PMC11001582	Source data To investigate whether ECM upregulation is associated with polyGR and polyPR expression or C9orf72 reduction, we performed quantitative proteomics on our eGFP knock-in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "To", "investigate", "whether", "ECM", "upregulation", "is", "associated", "with", "polyGR", "and", "polyPR", "expression", "or", "C9orf72", "reduction", ",", "we", "performed", "quantitative", "proteomics", "on", "our", "eGFP", "knock-in", "mice", "." ] } ]
PMC5025404	Each gene is under the control of its own promoter and is transcribed separately.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "gene", "is", "under", "the", "control", "of", "its", "own", "promoter", "and", "is", "transcribed", "separately", "." ] } ]
PMC10652261	Thiophene is a five-membered heteroaromatic ring containing a sulfur atom.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thiophene", "is", "a", "five-membered", "heteroaromatic", "ring", "containing", "a", "sulfur", "atom", "." ] } ]
PMC9341513	In the longer term, this points to a future role for the method in a clinical setting, for example, in personalized medicine, where structural predictions based on available or easily obtainable data could be extremely valuable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "longer", "term", ",", "this", "points", "to", "a", "future", "role", "for", "the", "method", "in", "a", "clinical", "setting", ",", "for", "example", ",", "in", "personalized", "medicine", ",", "where", "structural", "predictions", "based", "on", "available", "or", "easily", "obtainable", "data", "could", "be", "extremely", "valuable", "." ] } ]
PMC11739484	Correlation analysis was conducted using Spearman’s correlation coefficient to assess the strength and direction of the relationship between MMP expression levels and immune modulator genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "analysis", "was", "conducted", "using", "Spearman", "’s", "correlation", "coefficient", "to", "assess", "the", "strength", "and", "direction", "of", "the", "relationship", "between", "MMP", "expression", "levels", "and", "immune", "modulator", "genes", "." ] } ]
PMC9429973	Furthermore, compared to the control group, TQ05105 can strongly limit the ability of UKE1 cell lines, SET2 cell lines and primary cells from MPN patients (PMF, PV, ET) to form BFU-E and CFU-GM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "compared", "to", "the", "control", "group", ",", "TQ05105", "can", "strongly", "limit", "the", "ability", "of", "UKE1", "cell", "lines", ",", "SET2", "cell", "lines", "and", "primary", "cells", "from", "MPN", "patients", "(", "PMF", ",", "PV", ",", "ET", ")", "to", "form", "BFU-E", "and", "CFU-GM", "." ] } ]
PMC11461833	The LaminA/C expression level was measured by western blotting with an anti-Lamin A/C antibody, and a graph was generated. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "LaminA/C", "expression", "level", "was", "measured", "by", "western", "blotting", "with", "an", "anti-Lamin", "A/C", "antibody", ",", "and", "a", "graph", "was", "generated", ".", "(" ] } ]
PMC9848491	We used Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses in the “ggplot2” and “Heatmap” packages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "Kyoto", "Encyclopedia", "of", "Genes", "and", "Genomes", "(", "KEGG", ")", "and", "Gene", "Ontology", "(", "GO", ")", "analyses", "in", "the", "“", "ggplot2", "”", "and", "“", "Heatmap", "”", "packages", "." ] } ]
PMC8557138	Bray et al. developed a bioengineered star PEG-heparin hydrogel system equipped with tunable biochemical as well as mechanical properties that demonstrated the unique feature of replicating the tumor angiogenesis using HUVEC cells as well as in vivo drug response (Bray et al. 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bray", "et", "al.", "developed", "a", "bioengineered", "star", "PEG-heparin", "hydrogel", "system", "equipped", "with", "tunable", "biochemical", "as", "well", "as", "mechanical", "properties", "that", "demonstrated", "the", "unique", "feature", "of", "replicating", "the", "tumor", "angiogenesis", "using", "HUVEC", "cells", "as", "well", "as", "in", "vivo", "drug", "response", "(", "Bray", "et", "al.", "2015", ")", "." ] } ]
PMC8728081	We have explained the transformation of Rasasindura from raw mercury and sulphur.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "explained", "the", "transformation", "of", "Rasasindura", "from", "raw", "mercury", "and", "sulphur", "." ] } ]
PMC11461874	f HEK293T cells were transiently transfected with expression plasmid for Flag-DBP together with Myc-TRAF7 or Myc-TRAF7 ΔRING expression vectors.	[ { "tags": [ "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "HEK293", "T", "cells", "were", "transiently", "transfected", "with", "expression", "plasmid", "for", "Flag-DBP", "together", "with", "Myc-TRAF7", "or", "Myc-TRAF7", "ΔRING", "expression", "vectors", "." ] } ]
PMC9436459	The key feature of the synthesis included a biosynthesis-inspired asymmetric Diels–Alder cycloaddition mediated by a chiral ligand/boron Lewis acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "key", "feature", "of", "the", "synthesis", "included", "a", "biosynthesis-inspired", "asymmetric", "Diels", "–", "Alder", "cycloaddition", "mediated", "by", "a", "chiral", "ligand/boron", "Lewis", "acid", "." ] } ]
PMC11643491	The cells were maintained in MEM, and supplemented with 10% (v/v) fetal bovine serum, 1% pyruvate, 1% glutamine, 1% MEM vitamin solution, 1% antibiotic (streptomycin (10,000 µg/mL), and penicillin (10,000 units/mL) at 37 °C with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "maintained", "in", "MEM", ",", "and", "supplemented", "with", "10", "%", "(", "v/v", ")", "fetal", "bovine", "serum", ",", "1", "%", "pyruvate", ",", "1", "%", "glutamine", ",", "1", "%", "MEM", "vitamin", "solution", ",", "1", "%", "antibiotic", "(", "streptomycin", "(", "10,000", "µg/mL", ")", ",", "and", "penicillin", "(", "10,000", "units/mL", ")", "at", "37", "°", "C", "with", "5", "%", "CO2", "." ] } ]
PMC10470467	In short, this study constructed an accurate prognostic signature and identified 3 novel therapeutic targets against ES.Ewing sarcoma (ES) is the second most frequent aggressive bone or soft tissue tumor in children and is characterized by early metastatic spread, a high recurrence rate, and a poor 5-year survival rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "short", ",", "this", "study", "constructed", "an", "accurate", "prognostic", "signature", "and", "identified", "3", "novel", "therapeutic", "targets", "against", "ES.Ewing", "sarcoma", "(", "ES", ")", "is", "the", "second", "most", "frequent", "aggressive", "bone", "or", "soft", "tissue", "tumor", "in", "children", "and", "is", "characterized", "by", "early", "metastatic", "spread", ",", "a", "high", "recurrence", "rate", ",", "and", "a", "poor", "5-year", "survival", "rate", "." ] } ]
PMC8427838	Fig. 4Moesin stimulates and TMIGD1 inhibits filopodia protrusions and cell migration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "4Moesin", "stimulates", "and", "TMIGD1", "inhibits", "filopodia", "protrusions", "and", "cell", "migration", "." ] } ]
PMC11266100	Electroctroporation experiments were performed using a 3 kV, 100 ns–1 m square-wave pulse generator (VilniusTECH, Vilnius, Lithuania) (Novickij et al., 2016) and a commercially available electroporation cuvette with a 1 mm gap between electrodes (Biorad, Hercules, United States).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electroctroporation", "experiments", "were", "performed", "using", "a", "3", "kV", ",", "100", "ns–1", "m", "square-wave", "pulse", "generator", "(", "VilniusTECH", ",", "Vilnius", ",", "Lithuania", ")", "(", "Novickij", "et", "al.", ",", "2016", ")", "and", "a", "commercially", "available", "electroporation", "cuvette", "with", "a", "1", "mm", "gap", "between", "electrodes", "(", "Biorad", ",", "Hercules", ",", "United", "States", ")", "." ] } ]
PMC11365427	Limiting tumor nutrient absorption may provide novel treatment options.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Limiting", "tumor", "nutrient", "absorption", "may", "provide", "novel", "treatment", "options", "." ] } ]
PMC10810426	We found that NUP358/CA interaction occurred equally in the cytoplasm and nucleus in both cell types, while NUP62/CA occurred in the nucleus and at the nuclear membrane in DCs but not NIH3T3s, where it was mostly seen in the cytoplasm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "that", "NUP358/CA", "interaction", "occurred", "equally", "in", "the", "cytoplasm", "and", "nucleus", "in", "both", "cell", "types", ",", "while", "NUP62/CA", "occurred", "in", "the", "nucleus", "and", "at", "the", "nuclear", "membrane", "in", "DCs", "but", "not", "NIH3T3s", ",", "where", "it", "was", "mostly", "seen", "in", "the", "cytoplasm", "." ] } ]
PMC8973085	Anal.	[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]
PMC5261804	We correlated drug sensitivity measures from CCLE with interaction essentiality scores to identify critical interactions that predict therapeutic sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "correlated", "drug", "sensitivity", "measures", "from", "CCLE", "with", "interaction", "essentiality", "scores", "to", "identify", "critical", "interactions", "that", "predict", "therapeutic", "sensitivity", "." ] } ]
PMC6450504	However, PEGylation presents controversial and serious challenges including lack of functionality, hindered cellular interaction, allergic reactions, and stimulation of IgM production after repetitive dosing that accelerates blood clearance of the nanoparticles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "PEGylation", "presents", "controversial", "and", "serious", "challenges", "including", "lack", "of", "functionality", ",", "hindered", "cellular", "interaction", ",", "allergic", "reactions", ",", "and", "stimulation", "of", "IgM", "production", "after", "repetitive", "dosing", "that", "accelerates", "blood", "clearance", "of", "the", "nanoparticles", "." ] } ]
PMC11594806	This study provides additional evidence for the potential role of AMPK in OS .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "provides", "additional", "evidence", "for", "the", "potential", "role", "of", "AMPK", "in", "OS", "." ] } ]
PMC11521786	The 3LL-R3 (3LL-D122 derived) tumor line was previously generated at the Center of Molecular Immunology.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "3LL-R3", "(", "3LL-D122", "derived", ")", "tumor", "line", "was", "previously", "generated", "at", "the", "Center", "of", "Molecular", "Immunology", "." ] } ]
PMC9429973	Results: Hospital mortality in ALL patients was 30%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Hospital", "mortality", "in", "ALL", "patients", "was", "30", "%", "." ] } ]
PMC10669966	Through in vitro experiments, we observed elevated PDE3A expression correlating with high-grade myxoid samples and discovered that two LPS cell lines were responsive to PDE3A modulators.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "in", "vitro", "experiments", ",", "we", "observed", "elevated", "PDE3A", "expression", "correlating", "with", "high-grade", "myxoid", "samples", "and", "discovered", "that", "two", "LPS", "cell", "lines", "were", "responsive", "to", "PDE3A", "modulators", "." ] } ]
PMC11792740	In conclusion, this review offered a comprehensive overview of the current advancements in research on T-cell depletion, emphasizing its clinical manifestations, evaluation methods, mechanisms, and therapeutic strategies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "this", "review", "offered", "a", "comprehensive", "overview", "of", "the", "current", "advancements", "in", "research", "on", "T-cell", "depletion", ",", "emphasizing", "its", "clinical", "manifestations", ",", "evaluation", "methods", ",", "mechanisms", ",", "and", "therapeutic", "strategies", "." ] } ]
PMC11767817	5637 cells (at a density of 15 × 10 cells per well) were seeded in a white 96-well plate and incubated for 24 h at 37 °C and 5% CO2.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5637", "cells", "(", "at", "a", "density", "of", "15", "×", "10", "cells", "per", "well", ")", "were", "seeded", "in", "a", "white", "96-well", "plate", "and", "incubated", "for", "24", "h", "at", "37", "°", "C", "and", "5", "%", "CO2", "." ] } ]
PMC11395280	These results suggest that CCL198-83 inhibition of signaling in mice with T-ALL that express CCR7 substantially enhances survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "CCL198", "-", "83", "inhibition", "of", "signaling", "in", "mice", "with", "T-ALL", "that", "express", "CCR7", "substantially", "enhances", "survival", "." ] } ]
PMC11694625	Then, the mixture was slowly heated to 60 °C under stirring.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "mixture", "was", "slowly", "heated", "to", "60", "°", "C", "under", "stirring", "." ] } ]
PMC11782508	To determine the optimal period for azurin production, the strain was aerobically cultured in 100 mL of production medium broth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "determine", "the", "optimal", "period", "for", "azurin", "production", ",", "the", "strain", "was", "aerobically", "cultured", "in", "100", "mL", "of", "production", "medium", "broth", "." ] } ]
PMC9429973	Here we present a phase III trial evaluating asciminib vs an investigator-selected approved TKI in adult pts with newly diagnosed CML-CP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we", "present", "a", "phase", "III", "trial", "evaluating", "asciminib", "vs", "an", "investigator-selected", "approved", "TKI", "in", "adult", "pts", "with", "newly", "diagnosed", "CML-CP", "." ] } ]
PMC11248911	FS generated a three-descriptor model (eqn (1)) with a significantly high quality as shown in its statistical evaluation parameters and its predictions.1IC50 = −0.0012 × E − 0.0295 × log p(o/w) + 0.0583 × Mr + 5.0596 Autodock Vina software was used to perform the docking protocol, with a grid box of 25 Å centered on co-crystalized ligand in the active site of Aminopeptidase N which was retrieved from the protein data bank (PDB ID: 2DQM) using Exhaustiveness of 16.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FS", "generated", "a", "three-descriptor", "model", "(", "eqn", "(", "1", ")", ")", "with", "a", "significantly", "high", "quality", "as", "shown", "in", "its", "statistical", "evaluation", "parameters", "and", "its", "predictions.1IC50", "=", "−0.0012", "×", "E", "−", "0.0295", "×", "log", "p(o/w", ")", "+", "0.0583", "×", "Mr", "+", "5.0596", "Autodock", "Vina", "software", "was", "used", "to", "perform", "the", "docking", "protocol", ",", "with", "a", "grid", "box", "of", "25", "Å", "centered", "on", "co-crystalized", "ligand", "in", "the", "active", "site", "of", "Aminopeptidase", "N", "which", "was", "retrieved", "from", "the", "protein", "data", "bank", "(", "PDB", "ID", ":", "2DQM", ")", "using", "Exhaustiveness", "of", "16", "." ] } ]
PMC11271278	To call ecDNAs in CCLE cell lines we employed the AmpliconSuite pipeline (URL: https://github.com/jluebeck/AmpliconSuite-pipeline).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "call", "ecDNAs", "in", "CCLE", "cell", "lines", "we", "employed", "the", "AmpliconSuite", "pipeline", "(", "URL", ":", "https://github.com/jluebeck/AmpliconSuite-pipeline", ")", "." ] } ]
PMC11737091	GO and KEGG pathway enrichment analyses revealed a substantial enrichment of terms associated with cell division, whereas gene set enrichment analysis (GSEA) revealed correlations between increased DBF4 expression and the activation of cell cycle-related pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "and", "KEGG", "pathway", "enrichment", "analyses", "revealed", "a", "substantial", "enrichment", "of", "terms", "associated", "with", "cell", "division", ",", "whereas", "gene", "set", "enrichment", "analysis", "(", "GSEA", ")", "revealed", "correlations", "between", "increased", "DBF4", "expression", "and", "the", "activation", "of", "cell", "cycle-related", "pathways", "." ] } ]
PMC8973085	The produced precipitate was then filtered out, dried, and crystallized from the specified solvent, yielding the thieno[2,3-b]pyridine derivatives (5a–5h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "produced", "precipitate", "was", "then", "filtered", "out", ",", "dried", ",", "and", "crystallized", "from", "the", "specified", "solvent", ",", "yielding", "the", "thieno[2,3-b]pyridine", "derivatives", "(", "5a–5h", ")", "." ] } ]
PMC10165258	The FIC index of the three conditions shows a synergy in all cases, with the etoposide condition displaying the strongest synergy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FIC", "index", "of", "the", "three", "conditions", "shows", "a", "synergy", "in", "all", "cases", ",", "with", "the", "etoposide", "condition", "displaying", "the", "strongest", "synergy", "." ] } ]
PMC11026382	We use deep mutational scanning to quantify the growth rate effect of 2696 DHFR single mutations in 3 TYMS backgrounds under conditions selected to emphasize biochemical epistasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "use", "deep", "mutational", "scanning", "to", "quantify", "the", "growth", "rate", "effect", "of", "2696", "DHFR", "single", "mutations", "in", "3", "TYMS", "backgrounds", "under", "conditions", "selected", "to", "emphasize", "biochemical", "epistasis", "." ] } ]
PMC11129910	Treatment consisted of local excision in four cases (30.76%) or modified radical mastectomy in nine cases (69.23%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "consisted", "of", "local", "excision", "in", "four", "cases", "(", "30.76", "%", ")", "or", "modified", "radical", "mastectomy", "in", "nine", "cases", "(", "69.23", "%", ")", "." ] } ]
PMC11792766	Effect of organic solvents mixture at 0.5% v/v total organic concentration (0.25% and 0.25% v/v individual concentration) on the mean viability of exposed HepG2 and Caco‐2 for 24 h exposure as determined via MTT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "organic", "solvents", "mixture", "at", "0.5", "%", "v/v", "total", "organic", "concentration", "(", "0.25", "%", "and", "0.25", "%", "v/v", "individual", "concentration", ")", "on", "the", "mean", "viability", "of", "exposed", "HepG2", "and", "Caco‐2", "for", "24", "h", "exposure", "as", "determined", "via", "MTT", "." ] } ]
PMC11578343	Heatmap of the measured elastic G′ modulus for each single cell in each zone, grouped by risk.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", "of", "the", "measured", "elastic", "G′", "modulus", "for", "each", "single", "cell", "in", "each", "zone", ",", "grouped", "by", "risk", "." ] } ]
PMC9429973	Results: Median age of the patients was 68 years and the male:female ratio was 2,74.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Median", "age", "of", "the", "patients", "was", "68", "years", "and", "the", "male", ":", "female", "ratio", "was", "2,74", "." ] } ]
PMC11621493	For example, lecithin:cholesterol acyltransferase converts free cholesterol of circulating lipoproteins into cholesterol ester, which is then sequestered into the core of lipoprotein particles (6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "lecithin", ":", "cholesterol", "acyltransferase", "converts", "free", "cholesterol", "of", "circulating", "lipoproteins", "into", "cholesterol", "ester", ",", "which", "is", "then", "sequestered", "into", "the", "core", "of", "lipoprotein", "particles", "(", "6", ")", "." ] } ]
PMC11697189	A-C) Comparison of immune score (A), stromal score (B) and ESTIMATE score (C) between the two groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A-C", ")", "Comparison", "of", "immune", "score", "(", "A", ")", ",", "stromal", "score", "(", "B", ")", "and", "ESTIMATE", "score", "(", "C", ")", "between", "the", "two", "groups", "." ] } ]
PMC10317042	The cells were then transfected with Lipofectamine 2000 (Invitrogen) according to the manufacturer's protocol using 8 μg plasmid pCMV6‐XL5‐SOX10 (OriGene).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "transfected", "with", "Lipofectamine", "2000", "(", "Invitrogen", ")", "according", "to", "the", "manufacturer", "'s", "protocol", "using", "8", "μg", "plasmid", "pCMV6‐XL5‐SOX10", "(", "OriGene", ")", "." ] } ]
PMC11507371	Indeed, quantification of hydrogen peroxide in PAM showed that the hydrogen peroxide amount that was generated by 60 s of CAP treatment (492 µM) nearly equalled the hydrogen peroxide concentration used as a positive control in all experiments (441 µM) (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "quantification", "of", "hydrogen", "peroxide", "in", "PAM", "showed", "that", "the", "hydrogen", "peroxide", "amount", "that", "was", "generated", "by", "60", "s", "of", "CAP", "treatment", "(", "492", "µM", ")", "nearly", "equalled", "the", "hydrogen", "peroxide", "concentration", "used", "as", "a", "positive", "control", "in", "all", "experiments", "(", "441", "µM", ")", "(", "Figure", "4A", ")", "." ] } ]
PMC10380508	Thus, the downregulation of PAX gene expression in later stages of RCC may facilitate mesenchymal transition, which is linked to tumor cell invasion and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "the", "downregulation", "of", "PAX", "gene", "expression", "in", "later", "stages", "of", "RCC", "may", "facilitate", "mesenchymal", "transition", ",", "which", "is", "linked", "to", "tumor", "cell", "invasion", "and", "metastasis", "." ] } ]
PMC11568601	A TGT suppressed the lateral migration capacity of 143B and MG-63 cells in the scratch test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "TGT", "suppressed", "the", "lateral", "migration", "capacity", "of", "143B", "and", "MG-63", "cells", "in", "the", "scratch", "test", "." ] } ]
PMC10297204	Recurrence-free survival (RFS) was assessed every week from week one to week eight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recurrence-free", "survival", "(", "RFS", ")", "was", "assessed", "every", "week", "from", "week", "one", "to", "week", "eight", "." ] } ]
PMC11300639	k, l IHC staining of the tissue microarray of ccRCC (n = 38) with RNF26 or TSC1 antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "k", ",", "l", "IHC", "staining", "of", "the", "tissue", "microarray", "of", "ccRCC", "(", "n", "=", "38", ")", "with", "RNF26", "or", "TSC1", "antibodies", "." ] } ]
PMC11790599	The effect of tanshinlactone on the growth of human cancer cells was evaluated using sulforhodamine B and colony formation assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "tanshinlactone", "on", "the", "growth", "of", "human", "cancer", "cells", "was", "evaluated", "using", "sulforhodamine", "B", "and", "colony", "formation", "assay", "." ] } ]
PMC3730428	We further defined the mode of apoptosis induced by SAHA and AT-IAP/TNFα cotreatment to be caspase eight-dependent using siRNA to downregulate procaspase eight levels before treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "defined", "the", "mode", "of", "apoptosis", "induced", "by", "SAHA", "and", "AT-IAP/TNFα", "cotreatment", "to", "be", "caspase", "eight-dependent", "using", "siRNA", "to", "downregulate", "procaspase", "eight", "levels", "before", "treatment", "." ] } ]
PMC9429973	At the data cut-off (DCO), 49 patients completed at least one post-treatment Lugano assessment, of whom 21 (42.9%) achieved tumor response, including 11 complete responses (CRs, 22.4%) and 10 partial responses (20.4%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "data", "cut-off", "(", "DCO", ")", ",", "49", "patients", "completed", "at", "least", "one", "post-treatment", "Lugano", "assessment", ",", "of", "whom", "21", "(", "42.9", "%", ")", "achieved", "tumor", "response", ",", "including", "11", "complete", "responses", "(", "CRs", ",", "22.4", "%", ")", "and", "10", "partial", "responses", "(", "20.4", "%", ")", "." ] } ]
PMC9014716	Numerous studies have reported that miR-491-3b, miR-122, miR-223, and miR-503 can confer less resistance of hepatoma cells to ADM by binding to the 3′-UTR of targeted ABCB1 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numerous", "studies", "have", "reported", "that", "miR-491", "-", "3b", ",", "miR-122", ",", "miR-223", ",", "and", "miR-503", "can", "confer", "less", "resistance", "of", "hepatoma", "cells", "to", "ADM", "by", "binding", "to", "the", "3′-UTR", "of", "targeted", "ABCB1", "gene", "." ] } ]
PMC10165258	These results echo combination results obtained using segmented flow assays to perform coupled screens, by taking advantage the strong flexibility in determining the droplet contents both for micro-organisms and for cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "echo", "combination", "results", "obtained", "using", "segmented", "flow", "assays", "to", "perform", "coupled", "screens", ",", "by", "taking", "advantage", "the", "strong", "flexibility", "in", "determining", "the", "droplet", "contents", "both", "for", "micro-organisms", "and", "for", "cancer", "cells", "." ] } ]
PMC11453295	BLI suggests enhanced engraftment of CDH1 knockout cells compared to CDH1 wild-type HMECs and a survival advantage for HMECs expressing ESR1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BLI", "suggests", "enhanced", "engraftment", "of", "CDH1", "knockout", "cells", "compared", "to", "CDH1", "wild-type", "HMECs", "and", "a", "survival", "advantage", "for", "HMECs", "expressing", "ESR1", "." ] } ]
PMC11680578	p < 0.001 as compared to that of the RGZ group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.001", "as", "compared", "to", "that", "of", "the", "RGZ", "group", "." ] } ]
PMC11585587	MAPK signaling pathways, including p38, JNK, ERK5, and ERK, play a vital role in cell growth, development, and death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MAPK", "signaling", "pathways", ",", "including", "p38", ",", "JNK", ",", "ERK5", ",", "and", "ERK", ",", "play", "a", "vital", "role", "in", "cell", "growth", ",", "development", ",", "and", "death", "." ] } ]
PMC11551844	The FTIR spectra of JC-2 (Fig. 1S†) showed absorption bands at 3433 cm (O–H stretching); 2956–2865 cm (C–H stretching) and 1642 cm (absorption C <svg xmlns="http://www.w3.org/2000/svg" version="1.0" width="13.200000pt" height="16.000000pt" viewBox="0 0 13.200000 16.000000" preserveAspectRatio="xMidYMid meet"><metadata> Created by potrace 1.16, written by Peter Selinger 2001-2019 </metadata><g transform="translate(1.000000,15.000000) scale(0.017500,-0.017500)" fill="currentColor" stroke="none"><path d="M0 440 l0 -40 320 0 320 0 0 40 0 40 -320 0 -320 0 0 -40z M0 280 l0 -40 320 0 320 0 0 40 0 40 -320 0 -320 0 0 -40z"/></g></svg> C peak).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FTIR", "spectra", "of", "JC-2", "(", "Fig.", "1S†", ")", "showed", "absorption", "bands", "at", "3433", "cm", "(", "O", "–", "H", "stretching", ")", ";", "2956–2865", "cm", "(", "C", "–", "H", "stretching", ")", "and", "1642", "cm", "(", "absorption", "C", "<", "svg", "xmlns=\"http://www.w3.org/2000/svg", "\"", "version=\"1.0", "\"", "width=\"13.200000pt", "\"", "height=\"16.000000pt", "\"", "viewBox=\"0", "0", "13.200000", "16.000000", "\"", "preserveAspectRatio=\"xMidYMid", "meet\"><metadata", ">", "Created", "by", "potrace", "1.16", ",", "written", "by", "Peter", "Selinger", "2001", "-", "2019", "<", "/metadata><g", "transform=\"translate(1.000000,15.000000", ")", "scale(0.017500,-0.017500", ")", "\"", "fill=\"currentColor", "\"", "stroke=\"none\"><path", "d=\"M0", "440", "l0", "-40", "320", "0", "320", "0", "0", "40", "0", "40", "-320", "0", "-320", "0", "0", "-40z", "M0", "280", "l0", "-40", "320", "0", "320", "0", "0", "40", "0", "40", "-320", "0", "-320", "0", "0", "-40z\"/></g></svg", ">", "C", "peak", ")", "." ] } ]
PMC11335267	Instead, our data strongly suggests that reduced muscle mass is associated with denervation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Instead", ",", "our", "data", "strongly", "suggests", "that", "reduced", "muscle", "mass", "is", "associated", "with", "denervation", "." ] } ]
PMC11674441	Cancer vaccines targeting neoantigens represent a new modality for cancer treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "vaccines", "targeting", "neoantigens", "represent", "a", "new", "modality", "for", "cancer", "treatment", "." ] } ]
PMC11783017	In addition, we developed a hydrogel specifically designed to target the elevated ROS concentrations within the tumor microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "developed", "a", "hydrogel", "specifically", "designed", "to", "target", "the", "elevated", "ROS", "concentrations", "within", "the", "tumor", "microenvironment", "." ] } ]
PMC6889484	Thus, inhibition of virus replication was correlated with A3G-D128K expression and its antiviral activity in a subpopulation of target cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "inhibition", "of", "virus", "replication", "was", "correlated", "with", "A3G-D128", "K", "expression", "and", "its", "antiviral", "activity", "in", "a", "subpopulation", "of", "target", "cells", "." ] } ]
PMC11591052	Results are presented as the percentage of ATP level relative to the control (DMSO-treated cells) and given as the mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "presented", "as", "the", "percentage", "of", "ATP", "level", "relative", "to", "the", "control", "(", "DMSO-treated", "cells", ")", "and", "given", "as", "the", "mean", "±", "SEM", "." ] } ]
PMC11129910	The membrane was incubated overnight at 4°C with anti-GLS2 monoclonal mouse IgG (Novus Biologicals, Littleton, CO) and detected as described above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "membrane", "was", "incubated", "overnight", "at", "4", "°", "C", "with", "anti-GLS2", "monoclonal", "mouse", "IgG", "(", "Novus", "Biologicals", ",", "Littleton", ",", "CO", ")", "and", "detected", "as", "described", "above", "." ] } ]
PMC11782508	The IC50 values were determined to be 117.99 ± 1.12 µg/mL and 77.81 ± 0.56 µg/mL for crude and purified azurin, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "values", "were", "determined", "to", "be", "117.99", "±", "1.12", "µg/mL", "and", "77.81", "±", "0.56", "µg/mL", "for", "crude", "and", "purified", "azurin", ",", "respectively", "." ] } ]
PMC9429973	The median number of cycles received was 3 (range 1-28), with a median of one cycle to achieve the best response (range: 1-4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "number", "of", "cycles", "received", "was", "3", "(", "range", "1", "-", "28", ")", ",", "with", "a", "median", "of", "one", "cycle", "to", "achieve", "the", "best", "response", "(", "range", ":", "1", "-", "4", ")", "." ] } ]
PMC10759659	Hence, most current immunotherapeutic strategies act on reactive T cells to exert antitumour effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "most", "current", "immunotherapeutic", "strategies", "act", "on", "reactive", "T", "cells", "to", "exert", "antitumour", "effects", "." ] } ]
PMC11011837	Taurine and hypotaurine metabolism show a similar pattern, with CCRF-CEM displaying higher levels, possibly due to increased taurine abundance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taurine", "and", "hypotaurine", "metabolism", "show", "a", "similar", "pattern", ",", "with", "CCRF-CEM", "displaying", "higher", "levels", ",", "possibly", "due", "to", "increased", "taurine", "abundance", "." ] } ]
PMC9429973	Overall survival by group was estimated using the Kaplan–Meier method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", "survival", "by", "group", "was", "estimated", "using", "the", "Kaplan", "–", "Meier", "method", "." ] } ]
PMC11577421	To ensure complete NP coverage, the molar concentration of protein in solution was approximately 300 times higher than the estimated concentration of adsorbed protein, assuming ideal surface packing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "ensure", "complete", "NP", "coverage", ",", "the", "molar", "concentration", "of", "protein", "in", "solution", "was", "approximately", "300", "times", "higher", "than", "the", "estimated", "concentration", "of", "adsorbed", "protein", ",", "assuming", "ideal", "surface", "packing", "." ] } ]
PMC9429973	In 8/16 (50,0%) patients, C-MYC gene rearrangements were combined with a deletion of the TP53 gene.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "8/16", "(", "50,0", "%", ")", "patients", ",", "C-MYC", "gene", "rearrangements", "were", "combined", "with", "a", "deletion", "of", "the", "TP53", "gene", "." ] } ]
PMC9429973	Summary/Conclusion: This confirms the in principle selective druggability of gene expression of this central serine protease in a target-tissue specific manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "This", "confirms", "the", "in", "principle", "selective", "druggability", "of", "gene", "expression", "of", "this", "central", "serine", "protease", "in", "a", "target-tissue", "specific", "manner", "." ] } ]
PMC11422150	P values are based on the Steel–Dwass test. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "are", "based", "on", "the", "Steel", "–", "Dwass", "test", ".", "*" ] } ]
PMC11477621	Although great progress of chemotherapeutic agents has been made in cancer treatment, cancer-related deaths continue to dominate mortality due to drug resistance, which is the foremost reason for failure of cancer treatment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "great", "progress", "of", "chemotherapeutic", "agents", "has", "been", "made", "in", "cancer", "treatment", ",", "cancer-related", "deaths", "continue", "to", "dominate", "mortality", "due", "to", "drug", "resistance", ",", "which", "is", "the", "foremost", "reason", "for", "failure", "of", "cancer", "treatment", "." ] } ]
PMC10376064	The supernatant was disposed of in a freshly prepared storage buffer (HEPES (20 mM) and Na2-EDTA (0.1 mM)), subsequently followed by two further ultracentrifugation steps.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "was", "disposed", "of", "in", "a", "freshly", "prepared", "storage", "buffer", "(", "HEPES", "(", "20", "mM", ")", "and", "Na2-EDTA", "(", "0.1", "mM", ")", ")", ",", "subsequently", "followed", "by", "two", "further", "ultracentrifugation", "steps", "." ] } ]
PMC11637276	To address this, MDA-MB-231 cells and A2780-Rab25 cells were seeded on collagen I labelled with NHS-Alexa Fluor 555, a non-pH sensitive dye.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "address", "this", ",", "MDA-MB-231", "cells", "and", "A2780-Rab25", "cells", "were", "seeded", "on", "collagen", "I", "labelled", "with", "NHS-Alexa", "Fluor", "555", ",", "a", "non-pH", "sensitive", "dye", "." ] } ]
PMC9429973	The potential role of CSN5/Jab1 in modulation of anti-tumor immune responses in cancer, and particularly in ALCL, is unknown to date.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "potential", "role", "of", "CSN5/Jab1", "in", "modulation", "of", "anti-tumor", "immune", "responses", "in", "cancer", ",", "and", "particularly", "in", "ALCL", ",", "is", "unknown", "to", "date", "." ] } ]
PMC10976516	CAR T cells have a direct strong activity to kill cancer cells expressing TAAs on the cell surface but are susceptible to the TME with its immune suppressive modulators among others, such as immunosuppressive cytokines, immune checkpoint inhibitory receptors and ligands (e.g., PD-1, PD-L1, CTLA-4), and M2 phenotype TAMs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAR", "T", "cells", "have", "a", "direct", "strong", "activity", "to", "kill", "cancer", "cells", "expressing", "TAAs", "on", "the", "cell", "surface", "but", "are", "susceptible", "to", "the", "TME", "with", "its", "immune", "suppressive", "modulators", "among", "others", ",", "such", "as", "immunosuppressive", "cytokines", ",", "immune", "checkpoint", "inhibitory", "receptors", "and", "ligands", "(", "e.g.", ",", "PD-1", ",", "PD-L1", ",", "CTLA-4", ")", ",", "and", "M2", "phenotype", "TAMs", "." ] } ]
PMC11751675	The details of various sesquiterpene lactones (STLs) with potential antiviral activity are illustrated in Fig. 3 and elaborated upon in the following sections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "details", "of", "various", "sesquiterpene", "lactones", "(", "STLs", ")", "with", "potential", "antiviral", "activity", "are", "illustrated", "in", "Fig.", "3", "and", "elaborated", "upon", "in", "the", "following", "sections", "." ] } ]
PMC10723784	The cells were then left in the incubator and MTT assay was performed 96 h following the initial exposure to the drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "left", "in", "the", "incubator", "and", "MTT", "assay", "was", "performed", "96", "h", "following", "the", "initial", "exposure", "to", "the", "drugs", "." ] } ]
PMC9428827	In conclusion, our results extend previous studies from our group and other laboratories showing that IL-2 muteins can lead to an antitumor effect in vivo by expanding effector CD8 T cells while restricting the expansion of Treg cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "our", "results", "extend", "previous", "studies", "from", "our", "group", "and", "other", "laboratories", "showing", "that", "IL-2", "muteins", "can", "lead", "to", "an", "antitumor", "effect", "in", "vivo", "by", "expanding", "effector", "CD8", "T", "cells", "while", "restricting", "the", "expansion", "of", "Treg", "cells", "." ] } ]
PMC11026382	Gray spheres indicate the insignificant epistasis cluster.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gray", "spheres", "indicate", "the", "insignificant", "epistasis", "cluster", "." ] } ]
PMC11745823	PI3K, p‐PI3K, AKT, p‐AKT and c‐Myc levels were assessed by WB in Vector, oeRIT1, Vector + LY294002 and oeRIT1 + LY294002 groups. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PI3", "K", ",", "p‐PI3", "K", ",", "AKT", ",", "p‐AKT", "and", "c‐Myc", "levels", "were", "assessed", "by", "WB", "in", "Vector", ",", "oeRIT1", ",", "Vector", "+", "LY294002", "and", "oeRIT1", "+", "LY294002", "groups", ".", "(" ] } ]
PMC9429973	Results: In vitro, specific-amino acid deficiency leads to an increase in uptake of free fatty acids from the media to maintain membrane integrity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "In", "vitro", ",", "specific-amino", "acid", "deficiency", "leads", "to", "an", "increase", "in", "uptake", "of", "free", "fatty", "acids", "from", "the", "media", "to", "maintain", "membrane", "integrity", "." ] } ]
PMC9250505	Of those with OC treated with the combination of Ola and AZD5363, several patients achieved durable responses (4/6 stable disease (SD) and 1/7 partial response (PR)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "those", "with", "OC", "treated", "with", "the", "combination", "of", "Ola", "and", "AZD5363", ",", "several", "patients", "achieved", "durable", "responses", "(", "4/6", "stable", "disease", "(", "SD", ")", "and", "1/7", "partial", "response", "(", "PR", ")", ")", "." ] } ]
PMC11754432	Both TNFα and IFNγ treatments alone increased CCL2 expression, however, ALOX15B silencing significantly elevated CCL2 following IFNγ treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "TNFα", "and", "IFNγ", "treatments", "alone", "increased", "CCL2", "expression", ",", "however", ",", "ALOX15B", "silencing", "significantly", "elevated", "CCL2", "following", "IFNγ", "treatment", "." ] } ]
PMC6684588	Peak tetanic force generated by ACE-083-injected and vehicle-injected TA muscles as determined in situ.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peak", "tetanic", "force", "generated", "by", "ACE-083-injected", "and", "vehicle-injected", "TA", "muscles", "as", "determined", "in", "situ", "." ] } ]
PMC10530622	In cases of PH1, liver transplantation may be necessary to restore the deficient enzyme and normalize oxalate levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "cases", "of", "PH1", ",", "liver", "transplantation", "may", "be", "necessary", "to", "restore", "the", "deficient", "enzyme", "and", "normalize", "oxalate", "levels", "." ] } ]
PMC11419566	It is a dry fungus core for Wolfiporia cocos, a fungus of the family Poromycetes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "a", "dry", "fungus", "core", "for", "Wolfiporia", "cocos", ",", "a", "fungus", "of", "the", "family", "Poromycetes", "." ] } ]
PMC11476264	ZEB1 and its truncated mutants were expressed as His fusion protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZEB1", "and", "its", "truncated", "mutants", "were", "expressed", "as", "His", "fusion", "protein", "." ] } ]
PMC11549612	Firstly, it identifies the BOLA gene family (BOLA1, BOLA2, and BOLA3) as novel biomarkers for KIRC, highlighting their dysregulated expression in cell lines and tissue samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Firstly", ",", "it", "identifies", "the", "BOLA", "gene", "family", "(", "BOLA1", ",", "BOLA2", ",", "and", "BOLA3", ")", "as", "novel", "biomarkers", "for", "KIRC", ",", "highlighting", "their", "dysregulated", "expression", "in", "cell", "lines", "and", "tissue", "samples", "." ] } ]
PMC11525028	Animal studies were approved by Institutional Animal Care and Use Committee, Sun Yat-Sen University and were conducted according to established guidelines for the Use and Care of Laboratory Animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Animal", "studies", "were", "approved", "by", "Institutional", "Animal", "Care", "and", "Use", "Committee", ",", "Sun", "Yat-Sen", "University", "and", "were", "conducted", "according", "to", "established", "guidelines", "for", "the", "Use", "and", "Care", "of", "Laboratory", "Animals", "." ] } ]
PMC11726848	It is assumed that this might be due to the absence of a halt in cell cycle phases and cell–cell interactions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "assumed", "that", "this", "might", "be", "due", "to", "the", "absence", "of", "a", "halt", "in", "cell", "cycle", "phases", "and", "cell", "–", "cell", "interactions", "." ] } ]
PMC11422497	TUNEL assay was performed to determine the cell apoptosis rate in Xenograft tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TUNEL", "assay", "was", "performed", "to", "determine", "the", "cell", "apoptosis", "rate", "in", "Xenograft", "tumors", "." ] } ]
PMC7192625	Schematic view of the functionalities of the ChAseR R package. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "view", "of", "the", "functionalities", "of", "the", "ChAseR", "R", "package", ".", "(" ] } ]
PMC9429973	Results: As of 6 January 2022, 13 pts received zanubrutinib in cohort 2 (9 CLL/SLL; 2 WM; 1 MCL; 1 MZL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "As", "of", "6", "January", "2022", ",", "13", "pts", "received", "zanubrutinib", "in", "cohort", "2", "(", "9", "CLL/SLL", ";", "2", "WM", ";", "1", "MCL", ";", "1", "MZL", ")", "." ] } ]
PMC9429973	The inclusion/exclusion criteria were similar to those of the Ph3 clinical trial of CTX001 in patients with severe SCD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inclusion/exclusion", "criteria", "were", "similar", "to", "those", "of", "the", "Ph3", "clinical", "trial", "of", "CTX001", "in", "patients", "with", "severe", "SCD", "." ] } ]
PMC11792888	The cell cycle profiles of non-cancerous MRC-5 and CHO-K1 cells after scorpion venom treatment are shown in Figures 2 A and 2B.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "cycle", "profiles", "of", "non-cancerous", "MRC-5", "and", "CHO-K1", "cells", "after", "scorpion", "venom", "treatment", "are", "shown", "in", "Figures", "2", "A", "and", "2B", "." ] } ]

PMC11257988

The chemical structure of the KRASG12D inhibitor MRTX1133.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chemical", "structure", "of", "the", "KRASG12D", "inhibitor", "MRTX1133", "." ] } ]

PMC11756514

Nonetheless, CP can shield S. aureus from opsonization and phagocytosis (26, 57) and, as we show here, can impede recognition of the microorganism by several PPRs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ",", "CP", "can", "shield", "S.", "aureus", "from", "opsonization", "and", "phagocytosis", "(", "26", ",", "57", ")", "and", ",", "as", "we", "show", "here", ",", "can", "impede", "recognition", "of", "the", "microorganism", "by", "several", "PPRs", "." ] } ]

PMC11001582

Source data To investigate whether ECM upregulation is associated with polyGR and polyPR expression or C9orf72 reduction, we performed quantitative proteomics on our eGFP knock-in mice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "To", "investigate", "whether", "ECM", "upregulation", "is", "associated", "with", "polyGR", "and", "polyPR", "expression", "or", "C9orf72", "reduction", ",", "we", "performed", "quantitative", "proteomics", "on", "our", "eGFP", "knock-in", "mice", "." ] } ]

PMC5025404

Each gene is under the control of its own promoter and is transcribed separately.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "gene", "is", "under", "the", "control", "of", "its", "own", "promoter", "and", "is", "transcribed", "separately", "." ] } ]

PMC10652261

Thiophene is a five-membered heteroaromatic ring containing a sulfur atom.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thiophene", "is", "a", "five-membered", "heteroaromatic", "ring", "containing", "a", "sulfur", "atom", "." ] } ]

PMC9341513

In the longer term, this points to a future role for the method in a clinical setting, for example, in personalized medicine, where structural predictions based on available or easily obtainable data could be extremely valuable.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "longer", "term", ",", "this", "points", "to", "a", "future", "role", "for", "the", "method", "in", "a", "clinical", "setting", ",", "for", "example", ",", "in", "personalized", "medicine", ",", "where", "structural", "predictions", "based", "on", "available", "or", "easily", "obtainable", "data", "could", "be", "extremely", "valuable", "." ] } ]

PMC11739484

Correlation analysis was conducted using Spearman’s correlation coefficient to assess the strength and direction of the relationship between MMP expression levels and immune modulator genes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "analysis", "was", "conducted", "using", "Spearman", "’s", "correlation", "coefficient", "to", "assess", "the", "strength", "and", "direction", "of", "the", "relationship", "between", "MMP", "expression", "levels", "and", "immune", "modulator", "genes", "." ] } ]

PMC9429973

Furthermore, compared to the control group, TQ05105 can strongly limit the ability of UKE1 cell lines, SET2 cell lines and primary cells from MPN patients (PMF, PV, ET) to form BFU-E and CFU-GM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "compared", "to", "the", "control", "group", ",", "TQ05105", "can", "strongly", "limit", "the", "ability", "of", "UKE1", "cell", "lines", ",", "SET2", "cell", "lines", "and", "primary", "cells", "from", "MPN", "patients", "(", "PMF", ",", "PV", ",", "ET", ")", "to", "form", "BFU-E", "and", "CFU-GM", "." ] } ]

PMC11461833

The LaminA/C expression level was measured by western blotting with an anti-Lamin A/C antibody, and a graph was generated. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "LaminA/C", "expression", "level", "was", "measured", "by", "western", "blotting", "with", "an", "anti-Lamin", "A/C", "antibody", ",", "and", "a", "graph", "was", "generated", ".", "(" ] } ]

PMC9848491

We used Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses in the “ggplot2” and “Heatmap” packages.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "Kyoto", "Encyclopedia", "of", "Genes", "and", "Genomes", "(", "KEGG", ")", "and", "Gene", "Ontology", "(", "GO", ")", "analyses", "in", "the", "“", "ggplot2", "”", "and", "“", "Heatmap", "”", "packages", "." ] } ]

PMC8557138

Bray et al. developed a bioengineered star PEG-heparin hydrogel system equipped with tunable biochemical as well as mechanical properties that demonstrated the unique feature of replicating the tumor angiogenesis using HUVEC cells as well as in vivo drug response (Bray et al. 2015).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bray", "et", "al.", "developed", "a", "bioengineered", "star", "PEG-heparin", "hydrogel", "system", "equipped", "with", "tunable", "biochemical", "as", "well", "as", "mechanical", "properties", "that", "demonstrated", "the", "unique", "feature", "of", "replicating", "the", "tumor", "angiogenesis", "using", "HUVEC", "cells", "as", "well", "as", "in", "vivo", "drug", "response", "(", "Bray", "et", "al.", "2015", ")", "." ] } ]

PMC8728081

We have explained the transformation of Rasasindura from raw mercury and sulphur.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "explained", "the", "transformation", "of", "Rasasindura", "from", "raw", "mercury", "and", "sulphur", "." ] } ]

PMC11461874

f HEK293T cells were transiently transfected with expression plasmid for Flag-DBP together with Myc-TRAF7 or Myc-TRAF7 ΔRING expression vectors.

[ { "tags": [ "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "HEK293", "T", "cells", "were", "transiently", "transfected", "with", "expression", "plasmid", "for", "Flag-DBP", "together", "with", "Myc-TRAF7", "or", "Myc-TRAF7", "ΔRING", "expression", "vectors", "." ] } ]

PMC9436459

The key feature of the synthesis included a biosynthesis-inspired asymmetric Diels–Alder cycloaddition mediated by a chiral ligand/boron Lewis acid.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "key", "feature", "of", "the", "synthesis", "included", "a", "biosynthesis-inspired", "asymmetric", "Diels", "–", "Alder", "cycloaddition", "mediated", "by", "a", "chiral", "ligand/boron", "Lewis", "acid", "." ] } ]

PMC11643491

The cells were maintained in MEM, and supplemented with 10% (v/v) fetal bovine serum, 1% pyruvate, 1% glutamine, 1% MEM vitamin solution, 1% antibiotic (streptomycin (10,000 µg/mL), and penicillin (10,000 units/mL) at 37 °C with 5% CO2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "maintained", "in", "MEM", ",", "and", "supplemented", "with", "10", "%", "(", "v/v", ")", "fetal", "bovine", "serum", ",", "1", "%", "pyruvate", ",", "1", "%", "glutamine", ",", "1", "%", "MEM", "vitamin", "solution", ",", "1", "%", "antibiotic", "(", "streptomycin", "(", "10,000", "µg/mL", ")", ",", "and", "penicillin", "(", "10,000", "units/mL", ")", "at", "37", "°", "C", "with", "5", "%", "CO2", "." ] } ]

PMC10470467

In short, this study constructed an accurate prognostic signature and identified 3 novel therapeutic targets against ES.Ewing sarcoma (ES) is the second most frequent aggressive bone or soft tissue tumor in children and is characterized by early metastatic spread, a high recurrence rate, and a poor 5-year survival rate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "short", ",", "this", "study", "constructed", "an", "accurate", "prognostic", "signature", "and", "identified", "3", "novel", "therapeutic", "targets", "against", "ES.Ewing", "sarcoma", "(", "ES", ")", "is", "the", "second", "most", "frequent", "aggressive", "bone", "or", "soft", "tissue", "tumor", "in", "children", "and", "is", "characterized", "by", "early", "metastatic", "spread", ",", "a", "high", "recurrence", "rate", ",", "and", "a", "poor", "5-year", "survival", "rate", "." ] } ]

PMC8427838

Fig. 4Moesin stimulates and TMIGD1 inhibits filopodia protrusions and cell migration.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "4Moesin", "stimulates", "and", "TMIGD1", "inhibits", "filopodia", "protrusions", "and", "cell", "migration", "." ] } ]

PMC11266100

Electroctroporation experiments were performed using a 3 kV, 100 ns–1 m square-wave pulse generator (VilniusTECH, Vilnius, Lithuania) (Novickij et al., 2016) and a commercially available electroporation cuvette with a 1 mm gap between electrodes (Biorad, Hercules, United States).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Electroctroporation", "experiments", "were", "performed", "using", "a", "3", "kV", ",", "100", "ns–1", "m", "square-wave", "pulse", "generator", "(", "VilniusTECH", ",", "Vilnius", ",", "Lithuania", ")", "(", "Novickij", "et", "al.", ",", "2016", ")", "and", "a", "commercially", "available", "electroporation", "cuvette", "with", "a", "1", "mm", "gap", "between", "electrodes", "(", "Biorad", ",", "Hercules", ",", "United", "States", ")", "." ] } ]

PMC11365427

Limiting tumor nutrient absorption may provide novel treatment options.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Limiting", "tumor", "nutrient", "absorption", "may", "provide", "novel", "treatment", "options", "." ] } ]

PMC10810426

We found that NUP358/CA interaction occurred equally in the cytoplasm and nucleus in both cell types, while NUP62/CA occurred in the nucleus and at the nuclear membrane in DCs but not NIH3T3s, where it was mostly seen in the cytoplasm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "that", "NUP358/CA", "interaction", "occurred", "equally", "in", "the", "cytoplasm", "and", "nucleus", "in", "both", "cell", "types", ",", "while", "NUP62/CA", "occurred", "in", "the", "nucleus", "and", "at", "the", "nuclear", "membrane", "in", "DCs", "but", "not", "NIH3T3s", ",", "where", "it", "was", "mostly", "seen", "in", "the", "cytoplasm", "." ] } ]

PMC8973085

Anal.

[ { "tags": [ "O", "O" ], "tokens": [ "Anal", "." ] } ]

PMC5261804

We correlated drug sensitivity measures from CCLE with interaction essentiality scores to identify critical interactions that predict therapeutic sensitivity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "correlated", "drug", "sensitivity", "measures", "from", "CCLE", "with", "interaction", "essentiality", "scores", "to", "identify", "critical", "interactions", "that", "predict", "therapeutic", "sensitivity", "." ] } ]

PMC6450504

However, PEGylation presents controversial and serious challenges including lack of functionality, hindered cellular interaction, allergic reactions, and stimulation of IgM production after repetitive dosing that accelerates blood clearance of the nanoparticles.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "PEGylation", "presents", "controversial", "and", "serious", "challenges", "including", "lack", "of", "functionality", ",", "hindered", "cellular", "interaction", ",", "allergic", "reactions", ",", "and", "stimulation", "of", "IgM", "production", "after", "repetitive", "dosing", "that", "accelerates", "blood", "clearance", "of", "the", "nanoparticles", "." ] } ]

PMC11594806

This study provides additional evidence for the potential role of AMPK in OS .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "provides", "additional", "evidence", "for", "the", "potential", "role", "of", "AMPK", "in", "OS", "." ] } ]

PMC11521786

The 3LL-R3 (3LL-D122 derived) tumor line was previously generated at the Center of Molecular Immunology.

[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "3LL-R3", "(", "3LL-D122", "derived", ")", "tumor", "line", "was", "previously", "generated", "at", "the", "Center", "of", "Molecular", "Immunology", "." ] } ]

PMC9429973

Results: Hospital mortality in ALL patients was 30%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Hospital", "mortality", "in", "ALL", "patients", "was", "30", "%", "." ] } ]

PMC10669966

Through in vitro experiments, we observed elevated PDE3A expression correlating with high-grade myxoid samples and discovered that two LPS cell lines were responsive to PDE3A modulators.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "in", "vitro", "experiments", ",", "we", "observed", "elevated", "PDE3A", "expression", "correlating", "with", "high-grade", "myxoid", "samples", "and", "discovered", "that", "two", "LPS", "cell", "lines", "were", "responsive", "to", "PDE3A", "modulators", "." ] } ]

PMC11792740

In conclusion, this review offered a comprehensive overview of the current advancements in research on T-cell depletion, emphasizing its clinical manifestations, evaluation methods, mechanisms, and therapeutic strategies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "this", "review", "offered", "a", "comprehensive", "overview", "of", "the", "current", "advancements", "in", "research", "on", "T-cell", "depletion", ",", "emphasizing", "its", "clinical", "manifestations", ",", "evaluation", "methods", ",", "mechanisms", ",", "and", "therapeutic", "strategies", "." ] } ]

PMC11767817

5637 cells (at a density of 15 × 10 cells per well) were seeded in a white 96-well plate and incubated for 24 h at 37 °C and 5% CO2.

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5637", "cells", "(", "at", "a", "density", "of", "15", "×", "10", "cells", "per", "well", ")", "were", "seeded", "in", "a", "white", "96-well", "plate", "and", "incubated", "for", "24", "h", "at", "37", "°", "C", "and", "5", "%", "CO2", "." ] } ]

PMC11395280

These results suggest that CCL198-83 inhibition of signaling in mice with T-ALL that express CCR7 substantially enhances survival.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "CCL198", "-", "83", "inhibition", "of", "signaling", "in", "mice", "with", "T-ALL", "that", "express", "CCR7", "substantially", "enhances", "survival", "." ] } ]

PMC11694625

Then, the mixture was slowly heated to 60 °C under stirring.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "mixture", "was", "slowly", "heated", "to", "60", "°", "C", "under", "stirring", "." ] } ]

PMC11782508

To determine the optimal period for azurin production, the strain was aerobically cultured in 100 mL of production medium broth.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "determine", "the", "optimal", "period", "for", "azurin", "production", ",", "the", "strain", "was", "aerobically", "cultured", "in", "100", "mL", "of", "production", "medium", "broth", "." ] } ]

PMC9429973

Here we present a phase III trial evaluating asciminib vs an investigator-selected approved TKI in adult pts with newly diagnosed CML-CP.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", "we", "present", "a", "phase", "III", "trial", "evaluating", "asciminib", "vs", "an", "investigator-selected", "approved", "TKI", "in", "adult", "pts", "with", "newly", "diagnosed", "CML-CP", "." ] } ]

PMC11248911

FS generated a three-descriptor model (eqn (1)) with a significantly high quality as shown in its statistical evaluation parameters and its predictions.1IC50 = −0.0012 × E − 0.0295 × log p(o/w) + 0.0583 × Mr + 5.0596 Autodock Vina software was used to perform the docking protocol, with a grid box of 25 Å centered on co-crystalized ligand in the active site of Aminopeptidase N which was retrieved from the protein data bank (PDB ID: 2DQM) using Exhaustiveness of 16.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FS", "generated", "a", "three-descriptor", "model", "(", "eqn", "(", "1", ")", ")", "with", "a", "significantly", "high", "quality", "as", "shown", "in", "its", "statistical", "evaluation", "parameters", "and", "its", "predictions.1IC50", "=", "−0.0012", "×", "E", "−", "0.0295", "×", "log", "p(o/w", ")", "+", "0.0583", "×", "Mr", "+", "5.0596", "Autodock", "Vina", "software", "was", "used", "to", "perform", "the", "docking", "protocol", ",", "with", "a", "grid", "box", "of", "25", "Å", "centered", "on", "co-crystalized", "ligand", "in", "the", "active", "site", "of", "Aminopeptidase", "N", "which", "was", "retrieved", "from", "the", "protein", "data", "bank", "(", "PDB", "ID", ":", "2DQM", ")", "using", "Exhaustiveness", "of", "16", "." ] } ]

PMC11271278

To call ecDNAs in CCLE cell lines we employed the AmpliconSuite pipeline (URL: https://github.com/jluebeck/AmpliconSuite-pipeline).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "call", "ecDNAs", "in", "CCLE", "cell", "lines", "we", "employed", "the", "AmpliconSuite", "pipeline", "(", "URL", ":", "https://github.com/jluebeck/AmpliconSuite-pipeline", ")", "." ] } ]

PMC11737091

GO and KEGG pathway enrichment analyses revealed a substantial enrichment of terms associated with cell division, whereas gene set enrichment analysis (GSEA) revealed correlations between increased DBF4 expression and the activation of cell cycle-related pathways.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GO", "and", "KEGG", "pathway", "enrichment", "analyses", "revealed", "a", "substantial", "enrichment", "of", "terms", "associated", "with", "cell", "division", ",", "whereas", "gene", "set", "enrichment", "analysis", "(", "GSEA", ")", "revealed", "correlations", "between", "increased", "DBF4", "expression", "and", "the", "activation", "of", "cell", "cycle-related", "pathways", "." ] } ]

PMC8973085

The produced precipitate was then filtered out, dried, and crystallized from the specified solvent, yielding the thieno[2,3-b]pyridine derivatives (5a–5h).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "produced", "precipitate", "was", "then", "filtered", "out", ",", "dried", ",", "and", "crystallized", "from", "the", "specified", "solvent", ",", "yielding", "the", "thieno[2,3-b]pyridine", "derivatives", "(", "5a–5h", ")", "." ] } ]

PMC10165258

The FIC index of the three conditions shows a synergy in all cases, with the etoposide condition displaying the strongest synergy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FIC", "index", "of", "the", "three", "conditions", "shows", "a", "synergy", "in", "all", "cases", ",", "with", "the", "etoposide", "condition", "displaying", "the", "strongest", "synergy", "." ] } ]

PMC11026382

We use deep mutational scanning to quantify the growth rate effect of 2696 DHFR single mutations in 3 TYMS backgrounds under conditions selected to emphasize biochemical epistasis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "use", "deep", "mutational", "scanning", "to", "quantify", "the", "growth", "rate", "effect", "of", "2696", "DHFR", "single", "mutations", "in", "3", "TYMS", "backgrounds", "under", "conditions", "selected", "to", "emphasize", "biochemical", "epistasis", "." ] } ]

PMC11129910

Treatment consisted of local excision in four cases (30.76%) or modified radical mastectomy in nine cases (69.23%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "consisted", "of", "local", "excision", "in", "four", "cases", "(", "30.76", "%", ")", "or", "modified", "radical", "mastectomy", "in", "nine", "cases", "(", "69.23", "%", ")", "." ] } ]

PMC11792766

Effect of organic solvents mixture at 0.5% v/v total organic concentration (0.25% and 0.25% v/v individual concentration) on the mean viability of exposed HepG2 and Caco‐2 for 24 h exposure as determined via MTT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "organic", "solvents", "mixture", "at", "0.5", "%", "v/v", "total", "organic", "concentration", "(", "0.25", "%", "and", "0.25", "%", "v/v", "individual", "concentration", ")", "on", "the", "mean", "viability", "of", "exposed", "HepG2", "and", "Caco‐2", "for", "24", "h", "exposure", "as", "determined", "via", "MTT", "." ] } ]

PMC11578343

Heatmap of the measured elastic G′ modulus for each single cell in each zone, grouped by risk.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", "of", "the", "measured", "elastic", "G′", "modulus", "for", "each", "single", "cell", "in", "each", "zone", ",", "grouped", "by", "risk", "." ] } ]

PMC9429973

Results: Median age of the patients was 68 years and the male:female ratio was 2,74.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Median", "age", "of", "the", "patients", "was", "68", "years", "and", "the", "male", ":", "female", "ratio", "was", "2,74", "." ] } ]

PMC11621493

For example, lecithin:cholesterol acyltransferase converts free cholesterol of circulating lipoproteins into cholesterol ester, which is then sequestered into the core of lipoprotein particles (6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "lecithin", ":", "cholesterol", "acyltransferase", "converts", "free", "cholesterol", "of", "circulating", "lipoproteins", "into", "cholesterol", "ester", ",", "which", "is", "then", "sequestered", "into", "the", "core", "of", "lipoprotein", "particles", "(", "6", ")", "." ] } ]

PMC11697189

A-C) Comparison of immune score (A), stromal score (B) and ESTIMATE score (C) between the two groups.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A-C", ")", "Comparison", "of", "immune", "score", "(", "A", ")", ",", "stromal", "score", "(", "B", ")", "and", "ESTIMATE", "score", "(", "C", ")", "between", "the", "two", "groups", "." ] } ]

PMC10317042

The cells were then transfected with Lipofectamine 2000 (Invitrogen) according to the manufacturer's protocol using 8 μg plasmid pCMV6‐XL5‐SOX10 (OriGene).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "transfected", "with", "Lipofectamine", "2000", "(", "Invitrogen", ")", "according", "to", "the", "manufacturer", "'s", "protocol", "using", "8", "μg", "plasmid", "pCMV6‐XL5‐SOX10", "(", "OriGene", ")", "." ] } ]

PMC11507371

Indeed, quantification of hydrogen peroxide in PAM showed that the hydrogen peroxide amount that was generated by 60 s of CAP treatment (492 µM) nearly equalled the hydrogen peroxide concentration used as a positive control in all experiments (441 µM) (Figure 4A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "quantification", "of", "hydrogen", "peroxide", "in", "PAM", "showed", "that", "the", "hydrogen", "peroxide", "amount", "that", "was", "generated", "by", "60", "s", "of", "CAP", "treatment", "(", "492", "µM", ")", "nearly", "equalled", "the", "hydrogen", "peroxide", "concentration", "used", "as", "a", "positive", "control", "in", "all", "experiments", "(", "441", "µM", ")", "(", "Figure", "4A", ")", "." ] } ]

PMC10380508

Thus, the downregulation of PAX gene expression in later stages of RCC may facilitate mesenchymal transition, which is linked to tumor cell invasion and metastasis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "the", "downregulation", "of", "PAX", "gene", "expression", "in", "later", "stages", "of", "RCC", "may", "facilitate", "mesenchymal", "transition", ",", "which", "is", "linked", "to", "tumor", "cell", "invasion", "and", "metastasis", "." ] } ]

PMC11568601

A TGT suppressed the lateral migration capacity of 143B and MG-63 cells in the scratch test.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "TGT", "suppressed", "the", "lateral", "migration", "capacity", "of", "143B", "and", "MG-63", "cells", "in", "the", "scratch", "test", "." ] } ]

PMC10297204

Recurrence-free survival (RFS) was assessed every week from week one to week eight.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recurrence-free", "survival", "(", "RFS", ")", "was", "assessed", "every", "week", "from", "week", "one", "to", "week", "eight", "." ] } ]

PMC11300639

k, l IHC staining of the tissue microarray of ccRCC (n = 38) with RNF26 or TSC1 antibodies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "k", ",", "l", "IHC", "staining", "of", "the", "tissue", "microarray", "of", "ccRCC", "(", "n", "=", "38", ")", "with", "RNF26", "or", "TSC1", "antibodies", "." ] } ]

PMC11790599

The effect of tanshinlactone on the growth of human cancer cells was evaluated using sulforhodamine B and colony formation assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "tanshinlactone", "on", "the", "growth", "of", "human", "cancer", "cells", "was", "evaluated", "using", "sulforhodamine", "B", "and", "colony", "formation", "assay", "." ] } ]

PMC3730428

We further defined the mode of apoptosis induced by SAHA and AT-IAP/TNFα cotreatment to be caspase eight-dependent using siRNA to downregulate procaspase eight levels before treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "defined", "the", "mode", "of", "apoptosis", "induced", "by", "SAHA", "and", "AT-IAP/TNFα", "cotreatment", "to", "be", "caspase", "eight-dependent", "using", "siRNA", "to", "downregulate", "procaspase", "eight", "levels", "before", "treatment", "." ] } ]

PMC9429973

At the data cut-off (DCO), 49 patients completed at least one post-treatment Lugano assessment, of whom 21 (42.9%) achieved tumor response, including 11 complete responses (CRs, 22.4%) and 10 partial responses (20.4%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "data", "cut-off", "(", "DCO", ")", ",", "49", "patients", "completed", "at", "least", "one", "post-treatment", "Lugano", "assessment", ",", "of", "whom", "21", "(", "42.9", "%", ")", "achieved", "tumor", "response", ",", "including", "11", "complete", "responses", "(", "CRs", ",", "22.4", "%", ")", "and", "10", "partial", "responses", "(", "20.4", "%", ")", "." ] } ]

PMC9014716

Numerous studies have reported that miR-491-3b, miR-122, miR-223, and miR-503 can confer less resistance of hepatoma cells to ADM by binding to the 3′-UTR of targeted ABCB1 gene.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Numerous", "studies", "have", "reported", "that", "miR-491", "-", "3b", ",", "miR-122", ",", "miR-223", ",", "and", "miR-503", "can", "confer", "less", "resistance", "of", "hepatoma", "cells", "to", "ADM", "by", "binding", "to", "the", "3′-UTR", "of", "targeted", "ABCB1", "gene", "." ] } ]

PMC10165258

These results echo combination results obtained using segmented flow assays to perform coupled screens, by taking advantage the strong flexibility in determining the droplet contents both for micro-organisms and for cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "echo", "combination", "results", "obtained", "using", "segmented", "flow", "assays", "to", "perform", "coupled", "screens", ",", "by", "taking", "advantage", "the", "strong", "flexibility", "in", "determining", "the", "droplet", "contents", "both", "for", "micro-organisms", "and", "for", "cancer", "cells", "." ] } ]

PMC11453295

BLI suggests enhanced engraftment of CDH1 knockout cells compared to CDH1 wild-type HMECs and a survival advantage for HMECs expressing ESR1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BLI", "suggests", "enhanced", "engraftment", "of", "CDH1", "knockout", "cells", "compared", "to", "CDH1", "wild-type", "HMECs", "and", "a", "survival", "advantage", "for", "HMECs", "expressing", "ESR1", "." ] } ]

PMC11680578

p < 0.001 as compared to that of the RGZ group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.001", "as", "compared", "to", "that", "of", "the", "RGZ", "group", "." ] } ]

PMC11585587

MAPK signaling pathways, including p38, JNK, ERK5, and ERK, play a vital role in cell growth, development, and death.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MAPK", "signaling", "pathways", ",", "including", "p38", ",", "JNK", ",", "ERK5", ",", "and", "ERK", ",", "play", "a", "vital", "role", "in", "cell", "growth", ",", "development", ",", "and", "death", "." ] } ]

PMC11551844

The FTIR spectra of JC-2 (Fig. 1S†) showed absorption bands at 3433 cm (O–H stretching); 2956–2865 cm (C–H stretching) and 1642 cm (absorption C <svg xmlns="http://www.w3.org/2000/svg" version="1.0" width="13.200000pt" height="16.000000pt" viewBox="0 0 13.200000 16.000000" preserveAspectRatio="xMidYMid meet"><metadata> Created by potrace 1.16, written by Peter Selinger 2001-2019 </metadata><g transform="translate(1.000000,15.000000) scale(0.017500,-0.017500)" fill="currentColor" stroke="none"><path d="M0 440 l0 -40 320 0 320 0 0 40 0 40 -320 0 -320 0 0 -40z M0 280 l0 -40 320 0 320 0 0 40 0 40 -320 0 -320 0 0 -40z"/></g></svg> C peak).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "FTIR", "spectra", "of", "JC-2", "(", "Fig.", "1S†", ")", "showed", "absorption", "bands", "at", "3433", "cm", "(", "O", "–", "H", "stretching", ")", ";", "2956–2865", "cm", "(", "C", "–", "H", "stretching", ")", "and", "1642", "cm", "(", "absorption", "C", "<", "svg", "xmlns=\"http://www.w3.org/2000/svg", "\"", "version=\"1.0", "\"", "width=\"13.200000pt", "\"", "height=\"16.000000pt", "\"", "viewBox=\"0", "0", "13.200000", "16.000000", "\"", "preserveAspectRatio=\"xMidYMid", "meet\"><metadata", ">", "Created", "by", "potrace", "1.16", ",", "written", "by", "Peter", "Selinger", "2001", "-", "2019", "<", "/metadata><g", "transform=\"translate(1.000000,15.000000", ")", "scale(0.017500,-0.017500", ")", "\"", "fill=\"currentColor", "\"", "stroke=\"none\"><path", "d=\"M0", "440", "l0", "-40", "320", "0", "320", "0", "0", "40", "0", "40", "-320", "0", "-320", "0", "0", "-40z", "M0", "280", "l0", "-40", "320", "0", "320", "0", "0", "40", "0", "40", "-320", "0", "-320", "0", "0", "-40z\"/></g></svg", ">", "C", "peak", ")", "." ] } ]

PMC11335267

Instead, our data strongly suggests that reduced muscle mass is associated with denervation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Instead", ",", "our", "data", "strongly", "suggests", "that", "reduced", "muscle", "mass", "is", "associated", "with", "denervation", "." ] } ]

PMC11674441

Cancer vaccines targeting neoantigens represent a new modality for cancer treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "vaccines", "targeting", "neoantigens", "represent", "a", "new", "modality", "for", "cancer", "treatment", "." ] } ]

PMC11783017

In addition, we developed a hydrogel specifically designed to target the elevated ROS concentrations within the tumor microenvironment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "developed", "a", "hydrogel", "specifically", "designed", "to", "target", "the", "elevated", "ROS", "concentrations", "within", "the", "tumor", "microenvironment", "." ] } ]

PMC6889484

Thus, inhibition of virus replication was correlated with A3G-D128K expression and its antiviral activity in a subpopulation of target cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "inhibition", "of", "virus", "replication", "was", "correlated", "with", "A3G-D128", "K", "expression", "and", "its", "antiviral", "activity", "in", "a", "subpopulation", "of", "target", "cells", "." ] } ]

PMC11591052

Results are presented as the percentage of ATP level relative to the control (DMSO-treated cells) and given as the mean ± SEM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "presented", "as", "the", "percentage", "of", "ATP", "level", "relative", "to", "the", "control", "(", "DMSO-treated", "cells", ")", "and", "given", "as", "the", "mean", "±", "SEM", "." ] } ]

PMC11129910

The membrane was incubated overnight at 4°C with anti-GLS2 monoclonal mouse IgG (Novus Biologicals, Littleton, CO) and detected as described above.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "membrane", "was", "incubated", "overnight", "at", "4", "°", "C", "with", "anti-GLS2", "monoclonal", "mouse", "IgG", "(", "Novus", "Biologicals", ",", "Littleton", ",", "CO", ")", "and", "detected", "as", "described", "above", "." ] } ]

PMC11782508

The IC50 values were determined to be 117.99 ± 1.12 µg/mL and 77.81 ± 0.56 µg/mL for crude and purified azurin, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IC50", "values", "were", "determined", "to", "be", "117.99", "±", "1.12", "µg/mL", "and", "77.81", "±", "0.56", "µg/mL", "for", "crude", "and", "purified", "azurin", ",", "respectively", "." ] } ]

PMC9429973

The median number of cycles received was 3 (range 1-28), with a median of one cycle to achieve the best response (range: 1-4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "number", "of", "cycles", "received", "was", "3", "(", "range", "1", "-", "28", ")", ",", "with", "a", "median", "of", "one", "cycle", "to", "achieve", "the", "best", "response", "(", "range", ":", "1", "-", "4", ")", "." ] } ]

PMC10759659

Hence, most current immunotherapeutic strategies act on reactive T cells to exert antitumour effects.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "most", "current", "immunotherapeutic", "strategies", "act", "on", "reactive", "T", "cells", "to", "exert", "antitumour", "effects", "." ] } ]

PMC11011837

Taurine and hypotaurine metabolism show a similar pattern, with CCRF-CEM displaying higher levels, possibly due to increased taurine abundance.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taurine", "and", "hypotaurine", "metabolism", "show", "a", "similar", "pattern", ",", "with", "CCRF-CEM", "displaying", "higher", "levels", ",", "possibly", "due", "to", "increased", "taurine", "abundance", "." ] } ]

PMC9429973

Overall survival by group was estimated using the Kaplan–Meier method.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", "survival", "by", "group", "was", "estimated", "using", "the", "Kaplan", "–", "Meier", "method", "." ] } ]

PMC11577421

To ensure complete NP coverage, the molar concentration of protein in solution was approximately 300 times higher than the estimated concentration of adsorbed protein, assuming ideal surface packing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "ensure", "complete", "NP", "coverage", ",", "the", "molar", "concentration", "of", "protein", "in", "solution", "was", "approximately", "300", "times", "higher", "than", "the", "estimated", "concentration", "of", "adsorbed", "protein", ",", "assuming", "ideal", "surface", "packing", "." ] } ]

PMC9429973

In 8/16 (50,0%) patients, C-MYC gene rearrangements were combined with a deletion of the TP53 gene.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "8/16", "(", "50,0", "%", ")", "patients", ",", "C-MYC", "gene", "rearrangements", "were", "combined", "with", "a", "deletion", "of", "the", "TP53", "gene", "." ] } ]

PMC9429973

Summary/Conclusion: This confirms the in principle selective druggability of gene expression of this central serine protease in a target-tissue specific manner.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "This", "confirms", "the", "in", "principle", "selective", "druggability", "of", "gene", "expression", "of", "this", "central", "serine", "protease", "in", "a", "target-tissue", "specific", "manner", "." ] } ]

PMC11422150

P values are based on the Steel–Dwass test. *

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "are", "based", "on", "the", "Steel", "–", "Dwass", "test", ".", "*" ] } ]

PMC11477621

Although great progress of chemotherapeutic agents has been made in cancer treatment, cancer-related deaths continue to dominate mortality due to drug resistance, which is the foremost reason for failure of cancer treatment .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "great", "progress", "of", "chemotherapeutic", "agents", "has", "been", "made", "in", "cancer", "treatment", ",", "cancer-related", "deaths", "continue", "to", "dominate", "mortality", "due", "to", "drug", "resistance", ",", "which", "is", "the", "foremost", "reason", "for", "failure", "of", "cancer", "treatment", "." ] } ]

PMC10376064

The supernatant was disposed of in a freshly prepared storage buffer (HEPES (20 mM) and Na2-EDTA (0.1 mM)), subsequently followed by two further ultracentrifugation steps.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "was", "disposed", "of", "in", "a", "freshly", "prepared", "storage", "buffer", "(", "HEPES", "(", "20", "mM", ")", "and", "Na2-EDTA", "(", "0.1", "mM", ")", ")", ",", "subsequently", "followed", "by", "two", "further", "ultracentrifugation", "steps", "." ] } ]

PMC11637276

To address this, MDA-MB-231 cells and A2780-Rab25 cells were seeded on collagen I labelled with NHS-Alexa Fluor 555, a non-pH sensitive dye.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "address", "this", ",", "MDA-MB-231", "cells", "and", "A2780-Rab25", "cells", "were", "seeded", "on", "collagen", "I", "labelled", "with", "NHS-Alexa", "Fluor", "555", ",", "a", "non-pH", "sensitive", "dye", "." ] } ]

PMC9429973

The potential role of CSN5/Jab1 in modulation of anti-tumor immune responses in cancer, and particularly in ALCL, is unknown to date.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "potential", "role", "of", "CSN5/Jab1", "in", "modulation", "of", "anti-tumor", "immune", "responses", "in", "cancer", ",", "and", "particularly", "in", "ALCL", ",", "is", "unknown", "to", "date", "." ] } ]

PMC10976516

CAR T cells have a direct strong activity to kill cancer cells expressing TAAs on the cell surface but are susceptible to the TME with its immune suppressive modulators among others, such as immunosuppressive cytokines, immune checkpoint inhibitory receptors and ligands (e.g., PD-1, PD-L1, CTLA-4), and M2 phenotype TAMs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAR", "T", "cells", "have", "a", "direct", "strong", "activity", "to", "kill", "cancer", "cells", "expressing", "TAAs", "on", "the", "cell", "surface", "but", "are", "susceptible", "to", "the", "TME", "with", "its", "immune", "suppressive", "modulators", "among", "others", ",", "such", "as", "immunosuppressive", "cytokines", ",", "immune", "checkpoint", "inhibitory", "receptors", "and", "ligands", "(", "e.g.", ",", "PD-1", ",", "PD-L1", ",", "CTLA-4", ")", ",", "and", "M2", "phenotype", "TAMs", "." ] } ]

PMC11751675

The details of various sesquiterpene lactones (STLs) with potential antiviral activity are illustrated in Fig. 3 and elaborated upon in the following sections.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "details", "of", "various", "sesquiterpene", "lactones", "(", "STLs", ")", "with", "potential", "antiviral", "activity", "are", "illustrated", "in", "Fig.", "3", "and", "elaborated", "upon", "in", "the", "following", "sections", "." ] } ]

PMC10723784

The cells were then left in the incubator and MTT assay was performed 96 h following the initial exposure to the drugs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "then", "left", "in", "the", "incubator", "and", "MTT", "assay", "was", "performed", "96", "h", "following", "the", "initial", "exposure", "to", "the", "drugs", "." ] } ]

PMC9428827

In conclusion, our results extend previous studies from our group and other laboratories showing that IL-2 muteins can lead to an antitumor effect in vivo by expanding effector CD8 T cells while restricting the expansion of Treg cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "our", "results", "extend", "previous", "studies", "from", "our", "group", "and", "other", "laboratories", "showing", "that", "IL-2", "muteins", "can", "lead", "to", "an", "antitumor", "effect", "in", "vivo", "by", "expanding", "effector", "CD8", "T", "cells", "while", "restricting", "the", "expansion", "of", "Treg", "cells", "." ] } ]

PMC11026382

Gray spheres indicate the insignificant epistasis cluster.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gray", "spheres", "indicate", "the", "insignificant", "epistasis", "cluster", "." ] } ]

PMC11745823

PI3K, p‐PI3K, AKT, p‐AKT and c‐Myc levels were assessed by WB in Vector, oeRIT1, Vector + LY294002 and oeRIT1 + LY294002 groups. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PI3", "K", ",", "p‐PI3", "K", ",", "AKT", ",", "p‐AKT", "and", "c‐Myc", "levels", "were", "assessed", "by", "WB", "in", "Vector", ",", "oeRIT1", ",", "Vector", "+", "LY294002", "and", "oeRIT1", "+", "LY294002", "groups", ".", "(" ] } ]

PMC9429973

Results: In vitro, specific-amino acid deficiency leads to an increase in uptake of free fatty acids from the media to maintain membrane integrity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "In", "vitro", ",", "specific-amino", "acid", "deficiency", "leads", "to", "an", "increase", "in", "uptake", "of", "free", "fatty", "acids", "from", "the", "media", "to", "maintain", "membrane", "integrity", "." ] } ]

PMC9250505

Of those with OC treated with the combination of Ola and AZD5363, several patients achieved durable responses (4/6 stable disease (SD) and 1/7 partial response (PR)).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "those", "with", "OC", "treated", "with", "the", "combination", "of", "Ola", "and", "AZD5363", ",", "several", "patients", "achieved", "durable", "responses", "(", "4/6", "stable", "disease", "(", "SD", ")", "and", "1/7", "partial", "response", "(", "PR", ")", ")", "." ] } ]

PMC11754432

Both TNFα and IFNγ treatments alone increased CCL2 expression, however, ALOX15B silencing significantly elevated CCL2 following IFNγ treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "TNFα", "and", "IFNγ", "treatments", "alone", "increased", "CCL2", "expression", ",", "however", ",", "ALOX15B", "silencing", "significantly", "elevated", "CCL2", "following", "IFNγ", "treatment", "." ] } ]

PMC6684588

Peak tetanic force generated by ACE-083-injected and vehicle-injected TA muscles as determined in situ.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peak", "tetanic", "force", "generated", "by", "ACE-083-injected", "and", "vehicle-injected", "TA", "muscles", "as", "determined", "in", "situ", "." ] } ]

PMC10530622

In cases of PH1, liver transplantation may be necessary to restore the deficient enzyme and normalize oxalate levels.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "cases", "of", "PH1", ",", "liver", "transplantation", "may", "be", "necessary", "to", "restore", "the", "deficient", "enzyme", "and", "normalize", "oxalate", "levels", "." ] } ]

PMC11419566

It is a dry fungus core for Wolfiporia cocos, a fungus of the family Poromycetes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "a", "dry", "fungus", "core", "for", "Wolfiporia", "cocos", ",", "a", "fungus", "of", "the", "family", "Poromycetes", "." ] } ]

PMC11476264

ZEB1 and its truncated mutants were expressed as His fusion protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZEB1", "and", "its", "truncated", "mutants", "were", "expressed", "as", "His", "fusion", "protein", "." ] } ]

PMC11549612

Firstly, it identifies the BOLA gene family (BOLA1, BOLA2, and BOLA3) as novel biomarkers for KIRC, highlighting their dysregulated expression in cell lines and tissue samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Firstly", ",", "it", "identifies", "the", "BOLA", "gene", "family", "(", "BOLA1", ",", "BOLA2", ",", "and", "BOLA3", ")", "as", "novel", "biomarkers", "for", "KIRC", ",", "highlighting", "their", "dysregulated", "expression", "in", "cell", "lines", "and", "tissue", "samples", "." ] } ]

PMC11525028

Animal studies were approved by Institutional Animal Care and Use Committee, Sun Yat-Sen University and were conducted according to established guidelines for the Use and Care of Laboratory Animals.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Animal", "studies", "were", "approved", "by", "Institutional", "Animal", "Care", "and", "Use", "Committee", ",", "Sun", "Yat-Sen", "University", "and", "were", "conducted", "according", "to", "established", "guidelines", "for", "the", "Use", "and", "Care", "of", "Laboratory", "Animals", "." ] } ]

PMC11726848

It is assumed that this might be due to the absence of a halt in cell cycle phases and cell–cell interactions .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "assumed", "that", "this", "might", "be", "due", "to", "the", "absence", "of", "a", "halt", "in", "cell", "cycle", "phases", "and", "cell", "–", "cell", "interactions", "." ] } ]

PMC11422497

TUNEL assay was performed to determine the cell apoptosis rate in Xenograft tumors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TUNEL", "assay", "was", "performed", "to", "determine", "the", "cell", "apoptosis", "rate", "in", "Xenograft", "tumors", "." ] } ]

PMC7192625

Schematic view of the functionalities of the ChAseR R package. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "view", "of", "the", "functionalities", "of", "the", "ChAseR", "R", "package", ".", "(" ] } ]

PMC9429973

Results: As of 6 January 2022, 13 pts received zanubrutinib in cohort 2 (9 CLL/SLL; 2 WM; 1 MCL; 1 MZL).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "As", "of", "6", "January", "2022", ",", "13", "pts", "received", "zanubrutinib", "in", "cohort", "2", "(", "9", "CLL/SLL", ";", "2", "WM", ";", "1", "MCL", ";", "1", "MZL", ")", "." ] } ]

PMC9429973

The inclusion/exclusion criteria were similar to those of the Ph3 clinical trial of CTX001 in patients with severe SCD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inclusion/exclusion", "criteria", "were", "similar", "to", "those", "of", "the", "Ph3", "clinical", "trial", "of", "CTX001", "in", "patients", "with", "severe", "SCD", "." ] } ]

PMC11792888

The cell cycle profiles of non-cancerous MRC-5 and CHO-K1 cells after scorpion venom treatment are shown in Figures 2 A and 2B.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "cycle", "profiles", "of", "non-cancerous", "MRC-5", "and", "CHO-K1", "cells", "after", "scorpion", "venom", "treatment", "are", "shown", "in", "Figures", "2", "A", "and", "2B", "." ] } ]