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OTAR3088
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BioData-CellLine_annotated

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PMC11765678
Ferroptosis inducer-dependent oxidative stress and lipid peroxidation may bypass protective effects of ABC transporters and lead to sensitization of MDR tumors to chemotherapeutic agents.
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PMC11543885
For SDS-PAGE, place the samples on the magnetic rack.a.
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PMC9429973
Results: Analysis of publicly available TCGA AML transcriptomic data set (N=161), found that AML patients (N=82) who express below median CHD4 levels have a poorer prognostic outcome suggesting a link between stalled transcription enabling HR-based DDR and patient survival (P=0.047).
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PMC11095939
B–D) Either Nr1h3 or Rara KD promotes serum restimulation (SR)-induced quiescence exit in 3T3 cells. (
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PMC5330095
The current surge in the interest in medical Cannabis has rekindled research to validate the medicinal properties of this molecule, especially given that it is nonpsychoactive compared to its close derivative tetrahydrocannabinol.
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PMC11055323
Consequently, SS18-SSX1 is able to endow de novo H3K27ac in the entire SS18-SSX binding sites as shown by CUT&Tag experiments (Fig. 4d), although the intensity of global H3K27ac modification has been attenuated, especially at the intrinsic SS18 binding sites (Supplementary Fig. 11a-c).
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PMC9454178
D Gene expression profile in the Oncomine database.
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PMC11680391
The scale is sensitive to a single-unit difference in answer, but weighting was used to compensate for this.
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PMC11694066
.
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PMC11549062
Apoptosis was assessed by PI staining of cos7 cells treated with knockdown or overexpression of PTP1B and Rab5, respectively.
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PMC9964635
A distinctive peak around 22.0 ppm corresponded to the protons of two -CH3 carbon nuclei.
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PMC11269933
SGi and SAn represent the C. gigas and C. angulata were reared at southern site.(B) The relative expression of CgBraf and CgMras of C. gigas and C. angulata reared at northern (Qingdao, 35°44′ N) and southern (Xiamen, 24°33′ N) sampling sites, which was obtained from our previous study and reanalyzed in this study.
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PMC11012012
Korver et al. (2007) also analyzed the expression of SLAMF6/CD352 in various cell lines by Western blotting and found the highest level of SLAMF6/CD352 expression in B cell lines (CA46, Daudi, Raji, and Ramos).
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PMC11720107
Selected polyphenolic compounds were interpreted using LabSolution ver.
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PMC11514418
Furthermore, it was demonstrated that APS promoted the proliferation of human peripheral blood mononuclear cells, augmented the secretion of cytokines in a time- and dose-dependent manner, and increased the secretion of IL-6.
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PMC11128598
Then we assayed three different drug doses and calculated the CIs using the CompuSyn software.
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PMC9429973
Mild-moderate cGVHD had a protective effect on survival: median PFS of 38 months vs 8 if not cGVHD (p-value 0.03/HR 0.55 (CI 0.32-0.94)); and median OS of 19 months vs 11 if not cGVHD (p-value 0.001/HR 0.47 (CI 0.27-0.84)).
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PMC11734514
Lung cancer is recognized as a highly lethal disease, demanding swift and accurate solutions.
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PMC11286266
Membranes were scanned using an Odyssey near infrared imager (LI-COR) and signals were quantified using ImageJ software.
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PMC6160470
of at least three individual experiments performed in quadruplicates (a–c) or n = 3 individual experiments (d,e).
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PMC11746942
However, persistent STAT3 activation during skin inflammation is a distinguishing characteristic of psoriasis in patients and in imiquimod (IMQ)-induced psoriasiform dermatitis mouse model.
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PMC11064533
MS2 spectra were searched against the proteins from PROKKA annotated strain 4972 whole genome, supplemented with common contaminants (built-in option in MaxQuant).
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PMC9684669
The isoform-specific inhibitor of CAMK2D (the main cardiac isoform of CAMK2) could be used to target the cardiac-specific pathology of autonomously activated CAMK2 in diabetes (60), while avoiding off-target effects in other tissues, such as α and β isoforms of CAMK2, and disruption of memory formation in the hippocampus (61).
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PMC10006224
c Normalized read density plots for cohesin subunits ±2.5 kb of the summit in the different KD conditions from the heatmaps above.
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PMC11653168
no. sc-11427; Santa Cruz Biotechnology, Inc.) and β-actin (1:5,000; cat.
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PMC6650823
Unfortunately, the success of glioma chemotherapy is hampered by poor drug penetration across the blood–brain barrier (BBB) and consequent low intratumoral drug concentration.
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PMC10809689
The optical absorbance (OD) of each sample was read at a wavelength of 595 nm with the Microplate reader (Hyperion, Germany).
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PMC8916024
Evaluating the coverage of the sequencing across all taxa, we found that the rareaction curve tended to asymptote (Fig. S1), which indicated that the sequencing depth covered most of the species richness in the sample.
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PMC9429973
Summary/Conclusion: We recommend the individualized protection of vulnerable hematologyc diseases patients with long-term illness.
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PMC11397654
The phototheranostic ability of the complex was determined using MTT assays for testing cell viability of HeLa cells incubated with different concentrations of the AIEgen and the aggregate.
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PMC11696659
Luis Alberto Richart López: Writing – review & editing, Resources.
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PMC11314247
In this study, we observed that HO-AAVPA induced a higher level of apoptosis than VPA (68.43 vs. 47.68% in MCF-7 cells and 56.08 vs. 35.54% in MDA-MB-231 cells after 5 h of treatment).
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PMC9985266
50 μL of RIPA lysis and extraction buffer was added to the cultured cells and ground tissues, which were placed on ice for 20 min and centrifuged at 10,000 rpm for 10 min.
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PMC5025404
This paper is describing the development of a cell line based on Chinese Hamster (Cricetulus griseus) Ovary (CHO) cells.
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PMC11672617
These methods have a number of disadvantages, including the fact that they are labor-intensive, make it difficult to examine several samples in parallel, and often require cell lysis, which entails a loss of information about cytochrome c translocation in mitochondria.
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PMC10852540
Analyses were made with Statistical Package for the Social Sciences 20 (IBM, United States of America) and Graphpad programs, and p ≤ 0.05 was used.
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PMC10870498
The supernatant was collected and 10 µL of it was taken as the input group.
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PMC11705067
Heatmaps of the top 50 negative or positive FDX and DLAT expression correlated genes were plotted by the “pheatmap” R package.
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PMC11727306
SEA was found to be present in blood samples and synovial fluids from patients suffering from rheumatoid arthritis .
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PMC9220170
Thus, in this work, for the first time, the mechanisms of fine regulation of the processes of apoptosis, cell proliferation, and ER stress by two ER resident proteins, SELENOM and SELENOT, are touched upon, which is not only fundamental but also applied to clinical importance due to the close relationship between the calcium signaling system of cells, folding proteins-regulators of apoptosis and cell survival pathways.
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PMC9583612
However, individual sites can have significantly lower emissions than inventory estimates.(3)Characterizing operator-specific distributions of the frequency and duration of intermittent emission events is critical to developing an accurate annualized emissions estimate.
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PMC9822769
In recent decades, Pt(IV) derivatives have represented an interesting field of research.
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PMC6642070
A-204 cells were transduced with lentivirus for mRNA knockdown or cDNA expression and selected with puromycin before further analysis.
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PMC9822769
However, its particular behavior offers an unexpected example of active transport within the family of Pt(IV) complexes, a possible mechanism that should be taken into account in any future design of such promising agents.
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PMC4270159
b. Add the antibody solutions to the membranes and incubate them for 12–16 hr at 4°C.
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PMC11799978
FAP facilitates tumor growth and proliferation in multiple cancers.
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PMC10452486
It is evident that MEM series, and more particularly MEM-E/02, bind to the Face-2 of all HLA-Ia on the bead sets that are coated both with Face-1 and Face-2.
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PMC11461833
The HA-progerin-expressing HEK293 cell line was infected with lentiviruses carrying each of the above gRNAs, and stably transduced cells were selected with 1 g/ml puromycin for 3 days.
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PMC9429973
Among other cell types, CD4+ and CD8+ T cells are major players in the regulation of the microenvironment in malignancies.
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PMC6024716
As a result, volumetric productivity has been increased significantly in the last two decades by media optimization, careful process control , genetic modification , and cell line selection .
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PMC11803918
Importantly, hybrid exosomes further induced the activation and maturation of these immune cells, as indicated by the increase in CD83 and CD86 expressions in these cells after hybrid exosome treatment (Figure 8H,I).
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PMC11352666
NSCLC cells treated with MERTK inhibitors had decreased expression of anti-apoptotic BCL-2 and SURVIVIN proteins .
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PMC11078693
Aspirate most of the supernatant away to leave 2–3 mL in each tube.c.
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PMC9429973
Aims: To assess overall in-hospital survival of AML patients and concomitant coronavirus infection, as well as to assess survival taking into account various clinical factors.
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PMC9429973
Methods: This phase I dose-escalation and expansion study assessed the safety and efficacy of three dosages of C-CAR088 in patients with RRMM.
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PMC9429973
Dose-related increases in serum iron and TSAT as well as hepcidin reduction were seen in participants treated with DISC-0974 as compared to placebo.
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PMC11040965
Then, plasma cells (CD138) were purified from BMMC by automated magnetic sorting using anti-CD138 microbeads (Miltenyi Biotec).
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PMC11699178
In vitro experiments validate the mechanistic role of HIF-1α in GEM treatment, demonstrating that overexpression of HIF-1α reverses the drug's effects on ovarian cancer cells while silencing fibroblast growth factor receptor 1 (FGFR1) can restore treatment efficacy.
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PMC11750165
PEX1 encodes a member of the AAA-ATPase family, a large group of ATPase associated with the PBDs (Reuber et al., 1997).
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PMC9429973
An all-oral VEN + Oral-AZA combination regimen allows for outpatient administration and thus improves pt adherence [Eek 2016].
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PMC11535726
During surveys on saprobic fungi associated with woody plants in the subtropical and tropical forests of the Guizhou, Hainan and Yunnan Provinces in China, we discovered three previously undocumented taxa and one known species, which belong to Kirschsteiniothelia.
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PMC11307990
Thus far, numerous strategies proposed to deliver SUN molecules for enhancing bioavailability and delivery efficiency have been reported.
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PMC11680391
The frequency with which udder health is discussed and how potential problems are identified were associated with a lower BTSCC estimate of 427 cells/mL. In contrast, in general, cooperation between the dairy farmer and herd veterinarian was associated with an estimated increase of 604 cells/mL in BTSCC.
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PMC9429973
VEGF stimulated activation of SMAD (p<0.05) and STAT5 (p<0.01) signaling, prevented by Ruxolitinib and Rapamycin (p<0.01) in MNC of CLL.
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PMC9964654
For the dissolution of the polymer and [Au(cdc)2], CHCl3, ACN, or a mixture of DMF with DCM were used, while hydration was evaluated using H2O or PBS.
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PMC9275501
Chrysin could reduce methotrexate (MTX)-induced Hepatotoxicity (Ali et al., 2014).
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PMC11772585
Specifically, global METTL1 levels in tumor tissues continued to rise with increases in tumor stage (Fig. 1B).
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PMC9429973
Regarding variant filtering, sequencing and mapping errors were eliminated and intronic and synonymous variants were filtered out.
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PMC11047729
The growth of cells was also slowed in U937 cells in the xenograft mouse model, thanks to decreased telomerase levels.
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PMC9080589
Previous studies indicate that the Wnt/β-catenin pathway is frequently activated in a variety of human cancers, including PTC, and promotes tumor progression.
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PMC11544122
No. 635501) and Glutathione-superflow resin (cat.
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PMC9429973
However, although 77% of the patients can achieved a transplant with either strategies, only half of the original pts will receive a transplant from the prospected donor type.
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PMC10823017
c-Myc is reported to be the center of multiple pathways, and it plays a pivotal role in cell proliferation, survival, invasion, and the apoptosis in ccRCC.
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PMC11665584
Both the skin and oral mucosa undergo similar processes of terminal differentiation, but buccal keratinocytes do not keratinize like the skin and exist in an environment kept constantly moist and unexposed to UV damage (60).
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PMC11283030
As the first rate-timing enzyme for DNL, ACLY has been considered as a central metabolic enzyme in cancer.
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PMC11795610
p < 0.01 and ***p < 0.001 versus NOR group; p < 0.05, p < 0.01, and p < 0.001 versus High Ca group; p < 0.01 and p < 0.001 versus High Ca+GSK group.
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PMC11607321
Since only two omics were included, we removed the requirement for a sample to have data from at least two omics.
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PMC11787355
Of note, after initial tumor regression, some PTPRZ1-TCR-T-treated animals experienced tumor recurrence starting from day 42 onwards, yet by the predefined experimental endpoint, 33% (3 out of 9) of PTPRZ1-TCR-T cell-treated animals remained tumor-free, resulting in prolonged survival (Supplementary Fig. 7c, d).Fig.
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PMC11653533
A condition that causes inflammation and heart problems (Gilani et al., 2008).
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PMC11737091
P value of less than 0.05 was regarded as statistically significant.
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PMC9964654
The selection of the polymer has an important role in the formation of micelles, and it is based on the characteristics of both hydrophilic and hydrophobic block polymers.
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PMC3675084
All resistant cells were grown in paclitaxel-free, verapamil-free medium for at least two days prior to any assays.
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PMC10812665
To obtain an additional layer of information, we re-visited the transcriptome data with a specific focus on the c-I inhibitors (Rot, MPP and Ber).
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PMC11703992
Specifically, DDIT4 exhibit pro-inflammatory effects on GCA via promotes chronic, low-intensity inflammatory in CD4+ Memory T cell.
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PMC11679033
The same method was used to evaluate a potential toxic synergistic effect on cells exposed to a combination of CBD and CIT at approximately LOAEL doses (lowest observed adverse effect level, 1 and 30 μM for SH-SY5Y and HepG2, and 2 and 0.05 μM for HEK293, respectively).
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PMC6684588
Data represent 200 fibers per muscle (n = 10 mice). (
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PMC6133382
This unusual restriction in glycan maturation is thought to be a consequence of steric hindrance occurring during the formation of trimeric virus spike structures .
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PMC9917080
Previously, we showed that selenium nanoparticles (SeNPs) had an anticancer effect in various human tumor cell lines .
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PMC11310713
Similar to the serum FSH level, the serum level of LH exhibited a transient decrease in the early period after the initiation of pharmaceutical HRT, but these inhibitory effects were maintained in all rats treated with the pharmaceutical hormone compared to OVX rats over the 12 weeks (Fig. 4H and Fig. S2C and D).
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PMC4685407
Random integration is a common method in which randomly integrated transgenes cause variation in antibody productivity because they are located in various chromosomal regions that affect transgene expression levels.
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PMC9429973
C. Rakhit, S. Menzel, A. Nielsen Nardo-Marino, J. Strouboulis, D. Rees, B. Clark Precision Medicine, Viapath LLP; Red Cell Biology Group, King’s College London, London, United Kingdom; Department of Haematology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Red Cell Biology Group, Kings College London; Haematological Medicine, King’s College Hospital, London, United Kingdom Background: Sickle cell disease (SCD) is caused by a genetic variant in the HBB gene, forming HbS. Expression of fetal globin (HbF), reduces the severity of SCD.
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PMC9429973
Targeted sequencing was performed on 72% of patients (55/76) and the average number of mutations was 2(0-7).
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PMC10344560
He also presented with hypertension secondary to his kidney disease where blood pressure was well controlled with a combination of calcium channel blocker and angiotensin receptor blocker.
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PMC9429973
Further studies are needed to establish on whether monitoring these parameters may help in the decision on the duration of anticoagulation in this condition.
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PMC11665555
This decision was made considering that 75% of the patients who suffer from BCa are male.
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PMC2196094
Additional differences between MMCs derived from the two species include the fact that no direct homologue of MMCP-2 has yet been isolated in rat, and that no homologues of RMCP-3 and -4 have been isolated from mouse MCs (Fig. 7).
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PMC9250505
The therapeutic synergy, and mechanisms thereof, between a pBADS99 inhibitor and PARPis in EOC was determined in vitro and in vivo using cell line and patient-derived models.
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PMC11708541
Furthermore, C01 (86) exhibited a 10-fold higher potency than Crizotinib and potently suppressed enzymatic activity against clinically resistant ALK.
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PMC11721064
B–F Immunofluorescence staining (B and C) of LN-KS and LN-SH cells and quantitative analysis (D) of CK12 + cells percentages showed that LN treatment contributed to the generation of CK12 + cells.
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PMC9429973
T cell clones of 10 patients were monitored before and after immunosuppressive therapy (median time span: 9 months) by TCRβ repertoire sequencing.
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